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<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5J4</accession>
    <name>A0A1Y1U5J4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000027">
        <property type="protein sequence ID" value="ORX33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867651.1">
        <property type="nucleotide sequence ID" value="XM_022017330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5J4"/>
    <dbReference type="GeneID" id="33559139"/>
    <dbReference type="InParanoid" id="A0A1Y1U5J4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013344943" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="27318" checksum="E2C9AC491B86D339" modified="2017-08-30" version="1">MRSSIVIAAFSALALEAFAAPVKRGGILGGDILDGPIVSGNSILPILSDSNPTVVSPFTHSSSKRDGILGGEILDGPILSGNSILPIISTSDPLVVSPHTKSDKRDGILGGDLLDGPILSGNSILPILSDSEPTVVSPFTHSSSKRGILGGDLLDGPILSGNSILPILSDSEPTVVSPFTHSDSSSSKRDGILGGDLLDGPILSGNSILPILSDSEPTVVSPFTHSDSSKRDGILGGDLLDGPILSGNSILPILSDSNPTVASPFTHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5N9</accession>
    <name>A0A1Y1U5N9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_610682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000024">
        <property type="protein sequence ID" value="ORX33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867698.1">
        <property type="nucleotide sequence ID" value="XM_022014211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5N9"/>
    <dbReference type="GeneID" id="33556019"/>
    <dbReference type="InParanoid" id="A0A1Y1U5N9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="630"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="757" mass="86926" checksum="589DB2210064FCDB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5W0</accession>
    <name>A0A1Y1U5W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867758.1">
        <property type="nucleotide sequence ID" value="XM_022017276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5W0"/>
    <dbReference type="GeneID" id="33559085"/>
    <dbReference type="InParanoid" id="A0A1Y1U5W0"/>
    <dbReference type="OrthoDB" id="10397711at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="188" mass="21463" checksum="7D43B750C6F97969" modified="2017-08-30" version="1">MTEKRTSQDLLAELEKTKRDKRKKDQALLEAWGEAEDLRSAVLLAQQQKDDAISNASREADDLHATIQRVREEKSKAIAEGQGLNQRLEERLKETNGFVSRLQAQLALLEHSSDKSIFDLRQQLDMAQQEEARAKEEMESMRGRLDEAEFAHRALKEGGARLARDLGEKERRIIELEKAMGLRRGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U608</accession>
    <name>A0A1Y1U608_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_639873</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867798.1">
        <property type="nucleotide sequence ID" value="XM_022017292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U608"/>
    <dbReference type="FunCoup" id="A0A1Y1U608">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U608"/>
    <dbReference type="GeneID" id="33559101"/>
    <dbReference type="InParanoid" id="A0A1Y1U608"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="212"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="823"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="975"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1083"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1083"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1110" mass="125425" checksum="614B312F06CAF6D5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U633</accession>
    <name>A0A1Y1U633_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_639565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867820.1">
        <property type="nucleotide sequence ID" value="XM_022017248.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="33559057"/>
    <dbReference type="InParanoid" id="A0A1Y1U633"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
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    </dbReference>
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        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="182"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="755"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="930" mass="100616" checksum="48E51329A2205903" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6K7</accession>
    <name>A0A1Y1U6K7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_643835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867980.1">
        <property type="nucleotide sequence ID" value="XM_022017573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6K7"/>
    <dbReference type="GeneID" id="33559382"/>
    <dbReference type="InParanoid" id="A0A1Y1U6K7"/>
    <dbReference type="OrthoDB" id="2564718at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="379" mass="42030" checksum="7C1E6AFDE84B7FE2" modified="2017-08-30" version="1">MRFISATARPSLTPLGYRLLHLSEYKLANLEPRVGGREDGVALWKEVVVREAVRTAWKSVQQGTVGDLTDWSSKGAMGLDVIEEEEEDDDEESNSTSSTSSTVGQERQWFEDLVNSLGDDEVDDARTHEWAESFVETAFDDMEYDDEGIEAFTFPAISPPLSPSLPPSPVNGPLSLPTVSPTLTSRRRTDVEVIIVGSTDDAEPEDDQDLVADMTMSTRDSPSSPSAVSPPNRRVKYHFGPKPGDGVHRPLSPVLAALPSPTWSQKDKSATYDPDWKSTFDLDQRDPLDDCADDEFMLPPPMHRSMSTDSACSTDDDEECNCVTPPWPSGRSLEQLEDDDSEIEMNSTKFNRKEKDIPRPNSGSWLDLVVDRLEGLNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U713</accession>
    <name>A0A1Y1U713_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein CtaG/Cox11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_638674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868107.1">
        <property type="nucleotide sequence ID" value="XM_022017142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U713"/>
    <dbReference type="STRING" id="4999.A0A1Y1U713"/>
    <dbReference type="GeneID" id="33558951"/>
    <dbReference type="InParanoid" id="A0A1Y1U713"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="35141" checksum="CBD2143F540BB98B" modified="2017-08-30" version="1">MSTTMKHLISIPCKAGPSRASRPFSKLPPMSPAGPPRQSLSTMSRHLSPHPSSRLKHARSGTSTASLSAESTGSTLGTLTNDDIRKVWLAKNKAFQDARSKRNQTLLFYSLGAVFIMGGVTYAAIPLYRAFCSATGFAGTPITDPTRFSPDRLYTTPETEGRKRITVHFQATSSDVLPWKFEPQQRTVRVLPGETALAFYRAKNTSDKDIIGIATYNMTPDKIAPYFAKVECFCFEEQRIRAGEEVDLPVFFFIDRDIMDDPALENVDDIILSYTFFKARRNDMGHAIPDASEEAVLKSQGFDQYEHAPVKASAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7H0</accession>
    <name>A0A1Y1U7H0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AEX-3 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_637880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868269.1">
        <property type="nucleotide sequence ID" value="XM_022017061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7H0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7H0"/>
    <dbReference type="GeneID" id="33558870"/>
    <dbReference type="InParanoid" id="A0A1Y1U7H0"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="3">
        <location>
            <begin position="407"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="734"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124607" checksum="B354DA81FAD17561" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7K1</accession>
    <name>A0A1Y1U7K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_191694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868298.1">
        <property type="nucleotide sequence ID" value="XM_022012134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7K1"/>
    <dbReference type="FunCoup" id="A0A1Y1U7K1">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7K1"/>
    <dbReference type="GeneID" id="33553942"/>
    <dbReference type="InParanoid" id="A0A1Y1U7K1"/>
    <dbReference type="OrthoDB" id="2580353at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="29768" checksum="275015D78A075DF8" modified="2017-08-30" version="1">MSKVIFITGSSSGLGLELVKAALSQGHRVAATLRQPKDFPQSLLTEHADSLKTFPLDVTNKDQVDSALKATVEAFGKIDIIVNNAGWTVMGEFETMPEDLARKQFETVFWGTINVLKESIPLLRKQGGGKIVTVSSMVGLGGGLPLLSFFAAAKSGVEAVIDSVQAEMSPDWNIELRVVEPGGFKTEAMNKAGFVPPVAPYNAPDHPMTHFRNSFAGGTLGDASKAAQTILKFSSLEASPDVAKPARLVIGQDGIGYVDARLDGLKKQLAAWKDLAAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7P1</accession>
    <name>A0A1Y1U7P1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_639331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867883.1">
        <property type="nucleotide sequence ID" value="XM_022017219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7P1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7P1"/>
    <dbReference type="GeneID" id="33559028"/>
    <dbReference type="InParanoid" id="A0A1Y1U7P1"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="521" mass="57211" checksum="9C5EB8671591173E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U800</accession>
    <name>A0A1Y1U800_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase</fullName>
            <ecNumber evidence="5">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_638940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867937.1">
        <property type="nucleotide sequence ID" value="XM_022017176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U800"/>
    <dbReference type="STRING" id="4999.A0A1Y1U800"/>
    <dbReference type="GeneID" id="33558985"/>
    <dbReference type="InParanoid" id="A0A1Y1U800"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="33"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="495" mass="52451" checksum="A2043926C2D004D7" modified="2017-08-30" version="1">MPVFDTIIIGAGWSGAVAAKHLSSKGRSVLVLEARDRVGGRADTWKDGNVKVDVGCSWIHGYKEGNPARSIAEEHGVATHLPKPADGLIYGPDGLLSSSQANSLRAALSAAQSAFQLPYPPPPPTASLASALFGSDSPLFASAATADPSSDLNQTSPADPTTSSPASGSSKSADKANLVSLARSLEVPLGLKLEKASLRWTGWESLSNFAGSDAAPEGGYEALVRKVITKAVDHKAEVLLGTEVTSVKLQDDMITVTDRTGEIYRGKTVICTIPLGVLKTLPSSTFSPALPARTQEAIKGTHVGVLEKLLLVYPKAWWPKAETAGSFTFLPTSTQAISDTSTPREIFDASTLITANFACPSLPDPSPTLLTYLSETPALALLKHEPAEVVEAFHHFLMSRFGVEDSPPPSRSHLTNWYTDPLARGATTTPSIVSEHGERSPMDFKELSRPAWGGKLGFAGEATEMEHRGSVAGAVVSGQREAERVDRYLTMRSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U829</accession>
    <name>A0A1Y1U829_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF829-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_636902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868441.1">
        <property type="nucleotide sequence ID" value="XM_022016947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U829"/>
    <dbReference type="GeneID" id="33558756"/>
    <dbReference type="InParanoid" id="A0A1Y1U829"/>
    <dbReference type="OrthoDB" id="2564218at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30139" checksum="D5388C54EF5FF43D" modified="2017-08-30" version="1">MCIGVQAIPPQYDRLSDRVYVYRPASAESSDDLLILCMFMGAPPKVVAKYASEYGKRFSNMTILLVLSTIQSTFTPMVKARRDIEPAVDLIVDRCKRANGRIKGAVYSNGGLSSMIAIAKSVRAQTGSPLEIDGLIIDSAPSPPNDLTGAYKAFSASVPTAFKSFPVGIVTSLLICISLLVWWVLALVSGYGDPIDTLRLALNDQSLFRSETKRTYIYSKRDEIVHYSGVESSAADAEKQGWRVQKVQSTNTRHVAHSTGDREMYWNAVEDTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U870</accession>
    <name>A0A1Y1U870_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_647351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000027">
        <property type="protein sequence ID" value="ORX33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867666.1">
        <property type="nucleotide sequence ID" value="XM_022017640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U870"/>
    <dbReference type="STRING" id="4999.A0A1Y1U870"/>
    <dbReference type="GeneID" id="33559449"/>
    <dbReference type="InParanoid" id="A0A1Y1U870"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017762">
        <property type="entry name" value="Multicopper_oxidase_fun"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03390">
        <property type="entry name" value="ascorbOXfungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801856" description="laccase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="161"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="398"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="570" mass="63525" checksum="943A202AB8EB2833" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U882</accession>
    <name>A0A1Y1U882_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_196008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868025.1">
        <property type="nucleotide sequence ID" value="XM_022012152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U882"/>
    <dbReference type="GeneID" id="33553960"/>
    <dbReference type="InParanoid" id="A0A1Y1U882"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="207" mass="23213" checksum="6F98609587F291FC" modified="2017-08-30" version="1">MSIPAPTETRHFTVDWNTILSWQTGTWGDGSDCVSIVYPITYLGDSQFQKMKDDQAMNETSVSHNTCPGYGWEEQMLNSAPTSQGNESQYLADNHGVMSPLFSVSHQNDFDPATECSHQAHRRIDAIESNLYDLFEKGALAGSSELEHYFSNKKGTSSHSKPRKDRRVNRPILTCQSCRNSKLKCDKGRPCDTCSRLGKRCQYASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8F3</accession>
    <name>A0A1Y1U8F3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sexual development protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_594784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868597.1">
        <property type="nucleotide sequence ID" value="XM_022013836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8F3"/>
    <dbReference type="GeneID" id="33555644"/>
    <dbReference type="InParanoid" id="A0A1Y1U8F3"/>
    <dbReference type="OrthoDB" id="5293813at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011004602" evidence="1">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="350" mass="36088" checksum="7FB6130D3C8716DF" modified="2017-08-30" version="1">MLLSVAIAHTLLAGLTVAAPFSLPNGFPTPNNDALHQIFVAAGGSLPNTPLPTTLPSDAVTTLQVIAYNEIFEVAFFSSFLNNVTNGVEGFTDLPMDKSYIVDILTAVVNQESLHAIGANGILASANATTIPACNYMFPSTDFESAVAIADLFTAVVLGTLQSVVKGFATDMDNSTIALTGLIASIIGQEGEQAGGYRMIQGKIPSAAPFLTVSTGEFAFNAIAQTFIVPGSCDSVFKTIGVPMLDTLAVVQDSIQPTNQTVTFTTSCTHVTEGKDFVAYLSGQNAPVLVPVTNVQVTGDIATFSADLPFDNGFAHGLTIAAVVGTDTGLETAADVTAAAFAGPGLIQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Z0</accession>
    <name>A0A1Y1U8Z0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_636086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868741.1">
        <property type="nucleotide sequence ID" value="XM_022016865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Z0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8Z0"/>
    <dbReference type="GeneID" id="33558674"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Z0"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="6">
        <location>
            <begin position="121"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="569" mass="62745" checksum="6925072BBC94BD27" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U966</accession>
    <name>A0A1Y1U966_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868833.1">
        <property type="nucleotide sequence ID" value="XM_022018644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U966"/>
    <dbReference type="GeneID" id="33560453"/>
    <dbReference type="InParanoid" id="A0A1Y1U966"/>
    <dbReference type="OrthoDB" id="2563505at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="159" mass="17338" checksum="2A3818B916A21676" modified="2017-08-30" version="1">MISDPSILDDTSRPPPPGSYAFPLVLVIIICAGFLAYRRRQRAETFARDTSYTTRSALRLSTEEGPSAHSFLVNNASTDSLPSHALADLPTLPQVHDGLPPGSRGPEARLHSRSPDQVSAQKSSTRRSIRVRPPIEDDSDSEGESHEPAHGPRQTFSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9R3</accession>
    <name>A0A1Y1U9R3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_609926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869013.1">
        <property type="nucleotide sequence ID" value="XM_022014180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9R3"/>
    <dbReference type="GeneID" id="33555988"/>
    <dbReference type="InParanoid" id="A0A1Y1U9R3"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="911" mass="102828" checksum="561B38991418C014" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA09</accession>
    <name>A0A1Y1UA09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_635398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869105.1">
        <property type="nucleotide sequence ID" value="XM_022016807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA09"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA09"/>
    <dbReference type="GeneID" id="33558616"/>
    <dbReference type="InParanoid" id="A0A1Y1UA09"/>
    <dbReference type="OrthoDB" id="5809314at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="74" mass="8181" checksum="9829ACD9A7F6EAC3" modified="2017-08-30" version="1">MLGLHHCHHVSRQGRIVLHRDIKPENVLLSSDGTLKIADFGLSRTLREAESSATSFVGATLPQSSQGDRSMDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA64</accession>
    <name>A0A1Y1UA64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein DUF92-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_635730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868670.1">
        <property type="nucleotide sequence ID" value="XM_022016837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA64"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA64"/>
    <dbReference type="GeneID" id="33558646"/>
    <dbReference type="InParanoid" id="A0A1Y1UA64"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="293" mass="30914" checksum="A315C9DB0AC4EF62" modified="2017-08-30" version="1">MGSLYPIPAGISLLLAVHGLRKGSLSESGAISAFLVGYGHLANPTKAFGVALIVFYFIGSRATKVKAEIKAKLEDGPDPSKPGGNRNAMQVISNCIPSLLAALYFRFGPLSPSERLTQCPVDGLQKQLIYLALGQLATNFGDTLASELGILSPVRPRYILTARSVPPGTNGAVSTLGLLMSALGGAITSLVMILTLVIERRACKNDLSWAWEMLLFGMGAGFFGSLLDTVLGATLQETMYSTKDKRVLTDHSSRSTKEAGLKKLGFGLNVLSNSGVNFVSGTIMAGLGWLYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAE6</accession>
    <name>A0A1Y1UAE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_583432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868750.1">
        <property type="nucleotide sequence ID" value="XM_022013624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAE6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAE6"/>
    <dbReference type="GeneID" id="33555432"/>
    <dbReference type="InParanoid" id="A0A1Y1UAE6"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33709" checksum="0041D32BE58B79C7" modified="2017-08-30" version="1">MISDSSASGHQARKGSSATLTHDTLTSYNRSGNPNPESLGQCLDDNEDRSFRRRIKSYSQAKVDLNAVNLICVYACFITGFTNAISFSACYVWAGFQSANVANLGLALARTFNPLPYGTRSFLKGDQQLLVSLVSFCIGTSLGRIGEHIGSTRRVWLVGATFCQLLLAVVGTCCAHFSGEKGIALDRGDPSWASPMGMSALGLISASMGLQGIIGKRLGSPMNSTVVLTTTWVELFNDPFLFAFRYAPSRDVRIGGILAVFVGAFCSRGLIATKCGMTGTLGIMIGLRGLQIVWFCFMREEKSSVESSEPSSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAG2</accession>
    <name>A0A1Y1UAG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_633578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869218.1">
        <property type="nucleotide sequence ID" value="XM_022016635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAG2"/>
    <dbReference type="FunCoup" id="A0A1Y1UAG2">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAG2"/>
    <dbReference type="GeneID" id="33558444"/>
    <dbReference type="InParanoid" id="A0A1Y1UAG2"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="39543" checksum="6994EDB5428DB415" modified="2017-08-30" version="1">MFGWLAKPVTLISTIALSSLSLLSKRYQRVRYGYHLLIYVSTLGALSIWGVVVSVLASVTGQRLNINYYVARSFYNVCSPLINIRFIVEGEEHLTGLLRGGTDGQGQSAVLVGNHQSFLDILYLGRIFPRHASIMAKKELKWAPLLGQYLALSGAVFVDRKNRDAARLALEQAGDNMKKRQISLWVFPEGTRTLSAEPTLKTFKKGAFHLAIQAKVPVVPVVCENYHRLFDGKSRLDEGVLRIRVLPAITTEGMGPDDVSALTQSTREKMVATLREISAPGPLGRGPARDVPPLEKLPSEQQLGQPTEGRRRSSDDGSVADSQNGDSRNREEGQWDSTTEDEMDDDAVLLKKPTGSVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAI7</accession>
    <name>A0A1Y1UAI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_603864</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869238.1">
        <property type="nucleotide sequence ID" value="XM_022013965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAI7"/>
    <dbReference type="FunCoup" id="A0A1Y1UAI7">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAI7"/>
    <dbReference type="GeneID" id="33555773"/>
    <dbReference type="InParanoid" id="A0A1Y1UAI7"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="622" mass="67676" checksum="44CFD46ABF785BC5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAP9</accession>
    <name>A0A1Y1UAP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_636871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868433.1">
        <property type="nucleotide sequence ID" value="XM_022016943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UAP9">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAP9"/>
    <dbReference type="GeneID" id="33558752"/>
    <dbReference type="InParanoid" id="A0A1Y1UAP9"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="139" mass="14771" checksum="D6F0C3212A483BF5" modified="2017-08-30" version="1">MADVDMAADGHANGSSSGDWAARSVEGWIIIVTGLNEETTEEDLQDLFADYGEVKNLSMALNRRTGYVMGYALIEYANRDEAEKAIKGTNNTEFLEKTIKTDFAFSKGSAGGRKGGAAGAGGAGGRRTGRDRSVSPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAQ7</accession>
    <name>A0A1Y1UAQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_167667</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868443.1">
        <property type="nucleotide sequence ID" value="XM_022012079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAQ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAQ7"/>
    <dbReference type="GeneID" id="33553887"/>
    <dbReference type="InParanoid" id="A0A1Y1UAQ7"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="195" mass="21782" checksum="BC08297D950DC51F" modified="2017-08-30" version="1">MMASTVRSASLRLPLRSVSRVASTARILPAVRANSSTSAAVHGNENQVAQEQGGEMVERTVLNRDMHGVKMERLVHDKIPHGVDAFVVMPGYYADNAFNASRKAVEDHARETTELWRRLSYYVALPACLVTGIWVYLGEKEHADHRQALISSDANGGEPPERKVYSYMNIRTKPFPWGNQTLFFNPDVNIKAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB43</accession>
    <name>A0A1Y1UB43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_634864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869006.1">
        <property type="nucleotide sequence ID" value="XM_022016767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB43"/>
    <dbReference type="FunCoup" id="A0A1Y1UB43">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB43"/>
    <dbReference type="GeneID" id="33558576"/>
    <dbReference type="InParanoid" id="A0A1Y1UB43"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="52202" checksum="9029B379EAAD095E" modified="2017-08-30" version="1">MRGLCGSLLQPCRTVRFVRTRHARLAHPKAQAGMRPLTNESLSRLGRPQRPRSVCRTCLHCCAGSRANSSLAATPPSPWVTDIEAEHAEILRCCKAKVEEYKRLSTMPLSDSSVEELKEQTRTLKHLSRLAEAWDAYIGTRKAIIELRPHLQEEDESLREMFASEMASHIEQLDLIVQDQLSSLLLPQLSSDSLPAILSLHVGIGGGEAARFLEELAKMYKVYAAKKGWQVETLSEVEGPQAKGPGGNGLRETTMKIFPGEYGDEDASCFGDIMWESGIHRVQRVPPGATVDKMHSSTVSVNVSPIYPDTAEEPLIDPKDVRQEVMRARGAGGQHVNKTESAVRLTHVPTGIVVSMQDSRSQHENRAWAWDVLRARISERKRKEEQERRRAKRADKIKGVFRGDKVRTYNYPQDRVTDHRIGYNASDLAGIVSGENFDRIVAAMKEDFYKRRIEALMDGEEDLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBH4</accession>
    <name>A0A1Y1UBH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869581.1">
        <property type="nucleotide sequence ID" value="XM_022018512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBH4"/>
    <dbReference type="GeneID" id="33560321"/>
    <dbReference type="InParanoid" id="A0A1Y1UBH4"/>
    <dbReference type="OrthoDB" id="2576605at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="440" mass="47553" checksum="9243F95FDDA4CD3C" modified="2017-08-30" version="1">MVSDVCKIALAVCIPASFFTALFAFAMWFRRRRQQGLLQFVTAYHAPPLIDSRPLPNPPESPGLASRKASFGPPQFQETTITFRRLSAEPSKPDEIQRVNSITNNLHIQSDTTSDILPLGGRKSSIASDVSRSSIFCTSYSVRRVSAGGVEDIVNIQPAFIQNMALGPEEQLSFTPVTSEQVQPPVPLVDPPPSAARKHRRPDSITITLKTKPGLKSAASLRAIKSAIDTGSNGHQTAAGDSSKSPWSASTMDASAGVIFQAWRGFPAAQAETGDNVAIEDIRSPTQSRSPVADTQDSSETEHPHKDNKPSCEALHPVDIVKRRHSAADPRATPQQLQPRPLSLQHAAPVPSAMSSCTETGGSMPKSKAKLTYLSELAEEYKNNSLIVPAADRFVQEPSTSRLAKMLKAEISAHPPDEDHRVSSKPPVIPLPVSLQTSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBK7</accession>
    <name>A0A1Y1UBK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868728.1">
        <property type="nucleotide sequence ID" value="XM_022018635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBK7"/>
    <dbReference type="GeneID" id="33560444"/>
    <dbReference type="InParanoid" id="A0A1Y1UBK7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146634" evidence="1">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="385" mass="38353" checksum="F1CF07FE15C21616" modified="2017-08-30" version="1">MKFALLSAALGLLSATSASPIAAKRDAVQLGPCATTLCPGLGGLSLSISTPAISVNGDLTCVYTDLLNLLNGVKCVFDVNGVLLPGLSASQCLSAGSNGICQSCLTGYQLNAGQCVLNSLPPVTLTVVPTLTNYVTVPVTTIIPKITSTITGLNTVTVKATVTLSNPLPPATVTKTVTKTITSASGTVTNALTKTVTTGSPTKTQYELVFPTNCCPDAYLSLSAAVTGVSATANVKRDLSTVTVTALNTVTAVVTDKVGTLTGAAATVKVTVPAAKVTVGVTVTGKQKTVTKTSTVMATVTGGPKTVTATVTKSVPNTGVYTSTVTPPNVCPTAGLGISVGTGLGGVVSGLTPLQSAVQASLEAYAKLSAGLDVLVLCGSKLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBU4</accession>
    <name>A0A1Y1UBU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formin homology 2 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_111421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869220.1">
        <property type="nucleotide sequence ID" value="XM_022011933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBU4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBU4"/>
    <dbReference type="GeneID" id="33553741"/>
    <dbReference type="InParanoid" id="A0A1Y1UBU4"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345:SF8">
        <property type="entry name" value="FORMIN 3, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46345">
        <property type="entry name" value="INVERTED FORMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="455"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="956" mass="104711" checksum="F4AC06E0C16329A6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBY8</accession>
    <name>A0A1Y1UBY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_630482</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869693.1">
        <property type="nucleotide sequence ID" value="XM_022016337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBY8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBY8"/>
    <dbReference type="GeneID" id="33558146"/>
    <dbReference type="InParanoid" id="A0A1Y1UBY8"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="126"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="414" mass="45448" checksum="823106BB9D77CEFB" modified="2017-08-30" version="1">MSFLHIDSESPFSLDNLPFGVFSTKEKPYIRAGVAVGRHVIDLSALHRHGVFQGRLSDHASVFDSTSLNAFAALGRPFNQSYRLFVRNLLLADNPVLRDNEELRQDAIYDLDKVQMHLPMVIGDYTDFYAGRNHAYNVGVLFRGPENALQPNYLHLPVGYHGRASSVQISGQPVYRPNGQICPGPAPILSPCRKLDMELEIAAFICTPNPQGAPIPIQKASDHIFGFVLMNDWSARDIQAWEYVPLGPFNSKNFATTITPWVVLADAMEPFRVKAPDAPTGLLPYLTQDCNGAYDIDLTVDLRISGETHRLSRSNALHLCFSFEQMIAHHTITGCPLKTGDLFGSGTISGKEKDSLGSLLEMTLNGKEEMRLGSVSRTFLEDHDEVILNGAAGASGARVGFGPCIGRILPAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC00</accession>
    <name>A0A1Y1UC00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spt20 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869735.1">
        <property type="nucleotide sequence ID" value="XM_022016354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC00"/>
    <dbReference type="FunCoup" id="A0A1Y1UC00">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC00"/>
    <dbReference type="GeneID" id="33558163"/>
    <dbReference type="InParanoid" id="A0A1Y1UC00"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="77"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="368" mass="40902" checksum="1533F2FA0D19E84B" modified="2017-08-30" version="1">MQRRTIMGVLELPVGIHFSRLFLSLSTRILSYLDHTGTKSSASPPPSLPLIGGTMASASGYNHHRFARAVLKKSRKWEPSLVVQLYPQHWRFENSPMTFQYSGPMSPFLLALRAQVIPAALIPFLYDIRPPVSFVDGCLVVEIQDSRKAPEVRSRVVMRPAPEALAQTIDVMLERKGEDWDEHMALELESRIMAATSPPLYLGTSILSSRNAALAMSLTMPAGPNLAADGTYRDPTLSASGDDKSEVERMRKLLRAGERTGPFQPNWNILRVKETLENQERQKVQAQQVAPQHPQTAPTAPAVMAAGGSGEEKPKKPKKKRPDELVAPDDKKPSKKKKVDGEVKKKEIPSDKPKPKKKTVKKKPEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC5</accession>
    <name>A0A1Y1UCC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_682422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869816.1">
        <property type="nucleotide sequence ID" value="XM_022019151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC5"/>
    <dbReference type="FunCoup" id="A0A1Y1UCC5">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="33560960"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC5"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="313"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="702" mass="79130" checksum="8D4B2E0C1C4E9AC3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCQ8</accession>
    <name>A0A1Y1UCQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_631756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869963.1">
        <property type="nucleotide sequence ID" value="XM_022016458.1"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Sec_Metabolite_Reg"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
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        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
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            <begin position="300"/>
            <end position="310"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
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        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="500"/>
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            <end position="575"/>
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    </feature>
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        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
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        <location>
            <begin position="1306"/>
            <end position="1323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1337" mass="144204" checksum="431C959DF48A9E7C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCV1</accession>
    <name>A0A1Y1UCV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_682822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022019166.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZW10_C"/>
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        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="637"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="789"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="941" mass="103978" checksum="372D1B187C33C66C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDG8</accession>
    <name>A0A1Y1UDG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_520177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870158.1">
        <property type="nucleotide sequence ID" value="XM_022012985.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDG8"/>
    <dbReference type="GeneID" id="33554793"/>
    <dbReference type="InParanoid" id="A0A1Y1UDG8"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="893"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="946"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1320" mass="146932" checksum="DCBD8475411FD78E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDL0</accession>
    <name>A0A1Y1UDL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 65, N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_652024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870250.1">
        <property type="nucleotide sequence ID" value="XM_022018426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDL0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDL0"/>
    <dbReference type="GeneID" id="33560235"/>
    <dbReference type="InParanoid" id="A0A1Y1UDL0"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF3">
        <property type="entry name" value="ALPHA-FUCOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="423"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="778"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="856" mass="94618" checksum="2A69346B031DD1B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDV4</accession>
    <name>A0A1Y1UDV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_627909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870314.1">
        <property type="nucleotide sequence ID" value="XM_022016061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDV4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDV4"/>
    <dbReference type="GeneID" id="33557870"/>
    <dbReference type="InParanoid" id="A0A1Y1UDV4"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="35"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="352" mass="38023" checksum="19143405DD47AD53" modified="2017-08-30" version="1">MSLAVFSTSWLIRPTNSFSVIAMPSFTVFKGNKQGKPQKATTERPDKLEGDQVIVRVTASGLCGTDIHYKTQDMALGHEGAGVVEAVGPKVSELKVGDRVGWGYQHGSCGQCEQCLTGWETFCAKRQMYGYANLDQGSFATKGVWNESFLFKIPDGISDTDAAPLQCGGATVFNALQGVVPGEVVGIMGVGGLGHLAIQFASKMGCRVVVLSSSDRKKEEATKLGAHEFVATKDVDELKVSYPINRLLVTASAQPNWAQIIPILAPRAKIFPLSVDSGDFKIPYMPLILSGFTVQGSLVAARAVHRRMLDFAALHHISPVTEIFQMTEEGVNEAIDRLEKGDITYRAVLVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDW4</accession>
    <name>A0A1Y1UDW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_481731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870329.1">
        <property type="nucleotide sequence ID" value="XM_022012904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDW4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDW4"/>
    <dbReference type="GeneID" id="33554712"/>
    <dbReference type="InParanoid" id="A0A1Y1UDW4"/>
    <dbReference type="OrthoDB" id="9971601at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF2">
        <property type="entry name" value="METALLO-HYDROLASE_OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="503" mass="55972" checksum="49C00F1083FB26F1" modified="2017-08-30" version="1">MRSANQGVLHSPTPYDKFLNIFHQSCTDVSIQVQVDLSCQWDAIEVSAAMDVWLTPPVCHVVSSATLLGRRQPKTFDYVLVFTSFPGQSIDSQRSPSMVLWRSNDPLPPKSQGMVCNLDKIVTSAWERKRPILHHLNADTTWLIQLPVPNPSTSSTSRRWFNVLIDPWLFGPQSDVASWFSKQWHAIPPALASVPDVENLCRKVETITPGQEDPFDSSDHAHPIDAIVLSHEFTDHTHQLTLCQMPKSTRVFAASKAAALVQSWNHFDSISEIPSLQDASEWRDQTISLIPEVNTGEHTKSWVKVGRLQKEGDAFYYHSALAIIFDLSSSSTPESAPVEAIVYTPHGVRAEALNVLQRSNDETDQTVHHPIQTLALLHGLHDVSLDWGQQLNLGAFNALSAQRVVESKYWIGTHDEVKKGGGLVSWFLRRKVYTVREALEAESKSDTNLEEPSEKSAGAGFWSRKPQTQGGGDELAHLEEGGVDVGGRGKYYELRTGESMVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE49</accession>
    <name>A0A1Y1UE49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_628277</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870419.1">
        <property type="nucleotide sequence ID" value="XM_022016109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE49"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE49"/>
    <dbReference type="GeneID" id="33557918"/>
    <dbReference type="InParanoid" id="A0A1Y1UE49"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="331"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="436"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX36318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="561" mass="62333" checksum="6B00FE00ECD69B1B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE52</accession>
    <name>A0A1Y1UE52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_628116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870370.1">
        <property type="nucleotide sequence ID" value="XM_022016086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE52"/>
    <dbReference type="FunCoup" id="A0A1Y1UE52">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE52"/>
    <dbReference type="GeneID" id="33557895"/>
    <dbReference type="InParanoid" id="A0A1Y1UE52"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="21113" checksum="F902251C6617D50E" modified="2017-08-30" version="1">MFGAIVAGRLVQTNLQQIDDTHFVFPLEQPYDINHLTVFLLGTIPFPDGYGASVHFAWPGKDYIPLGVLTNAKPSAIFRVRKLVPPSGQSSSSSPPANLGIEIAPQPQIEEIASRLASGDMRGKEVAERVDVGKVAEKVVKNLFNYLHSFGGGEVNLTPDTPIPLSFFEKWYANFTRKIENDKGAAFLDRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEM2</accession>
    <name>A0A1Y1UEM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_629140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870611.1">
        <property type="nucleotide sequence ID" value="XM_022016177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEM2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEM2"/>
    <dbReference type="GeneID" id="33557986"/>
    <dbReference type="InParanoid" id="A0A1Y1UEM2"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="181" mass="19596" checksum="24AAF00D3D35D9FB" modified="2017-08-30" version="1">MNRRTVSQRVPPQTSTPAPILYPPSGPSSGRASPYPAPLSAGGPGSGFNHAPGTSNGLYQRSGSSASQYSESPFGGGMSSNGGYTRATHDVEGQNDERLEGLLGKVKVLKDITVGIGNEVRDGNLELTGMNDAFGSTSNFLNGTFRRMNKMAKKQGIGWCYFMLFLLFVLWIFVVVWWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEW0</accession>
    <name>A0A1Y1UEW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_570628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869769.1">
        <property type="nucleotide sequence ID" value="XM_022013051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEW0"/>
    <dbReference type="FunCoup" id="A0A1Y1UEW0">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEW0"/>
    <dbReference type="GeneID" id="33554859"/>
    <dbReference type="InParanoid" id="A0A1Y1UEW0"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="247"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="485" mass="54242" checksum="FD727F7BAA487989" modified="2017-08-30" version="1" fragment="single">YAHLSREELETRLASYEASSQSIASSSKLPLANARASKVKKTKRAFNFSTYPTRHIALLIAYEGWTFSGLAIQPLVEATSPTVEGELLKALERAKLIEAGKGWEGCGFSRCGRTDKGVSGAGQVVNLWVRSMKSKDHVRGPEGSWKEPSEILPPRVKLENQDASEQENSPPQSIREAKESFPAPEMFYPKILNAHLPPSIRVLAWSPVNPTFDSRFSCKNRHYKYAFHLVPSPGSIPLDLEAMRQGAKRLIGEHDFRNFCKLDGSKQIENHRRRVLKAWFDEPLASKDGDPSSSGMVMFNLVGTAFLWHQVRHIMAVLFLIGSRLEYPSVVTELLDIDKYPRRPLYLMADALPLRLHECGYEPGDLDWRVGSYDGLTSEMQGDARAIELEARGKLAGQLENARQEAEIRTWQTSSALGRMTELFGAMRTELPPAAHPMGGGDIRAGDKYVSIDKLSLGETVEVVNQTWREGRGKVRQLQRDARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFU3</accession>
    <name>A0A1Y1UFU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RuvB-like helicase</fullName>
            <ecNumber evidence="17">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_627736</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="17"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871000.1">
        <property type="nucleotide sequence ID" value="XM_022016039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFU3"/>
    <dbReference type="FunCoup" id="A0A1Y1UFU3">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFU3"/>
    <dbReference type="GeneID" id="33557848"/>
    <dbReference type="InParanoid" id="A0A1Y1UFU3"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002334">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 17" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="85"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="496" mass="53353" checksum="2091D3228EAE4581" modified="2017-08-30" version="1">MSLAQPTASSSAAPAGTNSGNGIITQPPPPTATRESRIATHSHIKGLGLADDGTAMEMSQGFVGQRTAREALGLHLQLLRMGRHSGRPLLLVGPPGTGKTAMALAMSQELGSKVPFCAMVGSEVYSGEVKKTEVLGSSFRRAIGLRIKETKEVYEGEVTELTPSEAENPLSGYGKTISHVIVGLKTVKGTKQLRLDPSVYEAIQKERVVVGDVIYIEANTGAVKRVGRSDAYASEFDLEAEEYVPLPKGDVHKRKELVQDVTLHDLDMANARPQGGQDIMSVMGQLVKGGRTEVTDKLRREINKVVDRYIEQGVAELVPGVLFIDEVHMLDMECFTYLNRALESPMSPYVVLASNRGMTTIRGTEYDGVVGGSGEGIRSPHGIPVDLLDRCMIVKTSLYSRDEIRKVLEIRSKIEGIVLRQEALDRLADEGEKTSLRFALQLLTPASILAKTMGQTEVGLDQIGELEGLFLDAKRSTGVLRGMTNGGGGGGSSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFZ5</accession>
    <name>A0A1Y1UFZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_628816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870535.1">
        <property type="nucleotide sequence ID" value="XM_022016148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFZ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFZ5"/>
    <dbReference type="GeneID" id="33557957"/>
    <dbReference type="InParanoid" id="A0A1Y1UFZ5"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="576" mass="63544" checksum="0C79F218DBD72FD1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG83</accession>
    <name>A0A1Y1UG83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871076.1">
        <property type="nucleotide sequence ID" value="XM_022018182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG83"/>
    <dbReference type="GeneID" id="33559991"/>
    <dbReference type="InParanoid" id="A0A1Y1UG83"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="182" mass="20863" checksum="F6B053CAD28F6A56" modified="2017-08-30" version="1">MPFDLGLYSLPYILLAWFLVADLFTGIMTITLRQVLVMSSTLVTALGLYSVKWISRHCPEKCPPLVFAATYVEAYFGSMIDSFECMIRGIFYFELVENTGMTIYAKTRFMGPLELVTQEDVSYVERIPRIYSEISDFVWIWLANLEETASEDGFEPIEMQIGPIPDAPWGYDHDWVPNPSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG98</accession>
    <name>A0A1Y1UG98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_642087</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871111.1">
        <property type="nucleotide sequence ID" value="XM_022017463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG98"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG98"/>
    <dbReference type="GeneID" id="33559272"/>
    <dbReference type="InParanoid" id="A0A1Y1UG98"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="31"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="528" mass="57353" checksum="679F9B880A9F0907" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGS2</accession>
    <name>A0A1Y1UGS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps5 C terminal like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_437792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871301.1">
        <property type="nucleotide sequence ID" value="XM_022012784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGS2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGS2"/>
    <dbReference type="GeneID" id="33554592"/>
    <dbReference type="InParanoid" id="A0A1Y1UGS2"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="437"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="763" mass="82834" checksum="EB158C092310B969" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGU3</accession>
    <name>A0A1Y1UGU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_625541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871321.1">
        <property type="nucleotide sequence ID" value="XM_022015810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGU3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGU3"/>
    <dbReference type="GeneID" id="33557619"/>
    <dbReference type="InParanoid" id="A0A1Y1UGU3"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="278" mass="29954" checksum="B45BB857D01CB06E" modified="2017-08-30" version="1">MALTPQALRLLSKELVRLRSDPPEGVRVIVDEDDLTAVEGLVQGPSGTPYEGGYFRIRFNFGPEYPNIPPKCTMITKIFHPNMSKQGEICVDTLKKGWKREYGVGHVLVTIKCLLIYPNPESALDEEAGKQLLADYDGYCKYARLMTSIHATPKITPIEFRDSSSKSSPSAPTPIAGLNLIHLPSSIPSSHSRPPNSTSSTTSSSTTTTTVTTTSTKPTASTRPAPLQAHAQQEQSPVMLSEPTAGEPEKPLKTVSSTKTPAKTAGAKAGAKRGLKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGU8</accession>
    <name>A0A1Y1UGU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_627024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870816.1">
        <property type="nucleotide sequence ID" value="XM_022015955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGU8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGU8"/>
    <dbReference type="GeneID" id="33557764"/>
    <dbReference type="InParanoid" id="A0A1Y1UGU8"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="721" mass="76633" checksum="7FA982284111AD42" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHC4</accession>
    <name>A0A1Y1UHC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871470.1">
        <property type="nucleotide sequence ID" value="XM_022018250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHC4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHC4"/>
    <dbReference type="GeneID" id="33560059"/>
    <dbReference type="InParanoid" id="A0A1Y1UHC4"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="46167" checksum="D96631DAF6786078" modified="2017-08-30" version="1">MLPYEGTPPPDEHPTLGVETSEAQSTDPLDRPLDDYRAEVPDHVKSLMGRMSRGKVYLLEETPAIIHVDGEERVRRDPRIAELAAQLDTHDPTAWLAAVSESVRSPIRPNALFIRSDVIKHLSTSKVFSWTTSLGAGVMGIEWLNDTTLILLFPTPAAALLALTLLSKAGFDPTEGDDPLLERSAHTVPIHLLPQAELDPTDSKAGTELLASSQPEDSSAPRRRGRGTFASSQSGSDRPLLASDEMANEWNLAPGVDANARITVRFAVESDSELRREAKMSEWYQRHGRRAGKETATGARRSMGREDDAQLTWQGRDSGEGREFAKRISRERRDPYSRPSGNDRARGRGRRTAEDLDKELEGFARRRNGQDGDETMDLDADLNGSGDGRRQRRDRRGKEDLDSELDSMFAARNPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHP8</accession>
    <name>A0A1Y1UHP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_641779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871580.1">
        <property type="nucleotide sequence ID" value="XM_022017446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHP8"/>
    <dbReference type="FunCoup" id="A0A1Y1UHP8">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHP8"/>
    <dbReference type="GeneID" id="33559255"/>
    <dbReference type="InParanoid" id="A0A1Y1UHP8"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="428" mass="46789" checksum="F930085AF07F8310" modified="2017-08-30" version="1">MAYSNLLKPDEPGTLLVEKVCTRLRRRQIVGSHNIALETAQLIYAIVRVVKFSTLDELLALLKLIGRRLNEANPKELASGNIVRRILRLFREEYRAAAATQITQPSTPLSGPETPGLHAPSSHYLSQDLSMTTTPPRTQNHSPNLGGTSTLPVPSRAPSLSNFVAFRHSRAQLERSGSTLSELTQAAASIENEEFMRQSAKLKPIFIQAIEEVIGELETTHDDVAKGAREHIHSAEVIMTLGHSKTVETFIKHAYRDRKFTVIVVESAPSYLGHTMAKSLSASNIPTILIPDSSVHALMPRVTKVVLGAHSILANGGLFALSGTLSACLAAKAFSKPVVVTTGQFKFAPVWNLYHEHGAVDFQSPGNVLGYEGDGSAGGITGVTTNAPYYEYIRPELINLFVTNEGDHSPSYIYRIIKEAYDEEDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHU9</accession>
    <name>A0A1Y1UHU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_622653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871605.1">
        <property type="nucleotide sequence ID" value="XM_022015494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHU9"/>
    <dbReference type="GeneID" id="33557303"/>
    <dbReference type="InParanoid" id="A0A1Y1UHU9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="181" mass="19787" checksum="0DF106CAF06A7290" modified="2017-08-30" version="1">MSQLSPGTKRLLALGGLAAMHFALRPTAPTHWTMCDPTVDRATRGSIVENLTNTVRDLWQPRGSIYITPNRFESPSLLYDGSDGPPPSFLTKVRGGSSFKFDTEIPFVKDDGTVGTYKRSCTVYHDGEPTRLSQVMLPSRYGKVGAAIPVSPDIFGSGRISCSSSSTQIENHVRDGRVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHX3</accession>
    <name>A0A1Y1UHX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_461194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870754.1">
        <property type="nucleotide sequence ID" value="XM_022012850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHX3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHX3"/>
    <dbReference type="GeneID" id="33554658"/>
    <dbReference type="InParanoid" id="A0A1Y1UHX3"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="304" mass="33434" checksum="078C558EE7835BB1" modified="2017-08-30" version="1">MRLRRAYLPPVKTLAKRSQVYNNRSESEDTSSDISALGGGCAGCGRKRNVSNWTMIHPCGHILCWTCFSATIASVTKSHAASKCTACQGDCLSIKRHYGPVPKDNGPEHCNAVNPGASTPCCSDTIVLRIDNVDVTPQIVENFLPKNVLPQEHPQPIHILIDRFDGRTKDYMYIEAASDVTARKILKKRQNGMMPCGGQDGKTRAVTITRVTHHELSAELRPKGPQELTALLALCQAAVALPNRADRDLCHSPSVTRSGLAHFVKSRHGPFYAIMSILTKLRGPESPAYWDLFNLTSGIYTVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI10</accession>
    <name>A0A1Y1UI10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871665.1">
        <property type="nucleotide sequence ID" value="XM_022015520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI10"/>
    <dbReference type="GeneID" id="33557329"/>
    <dbReference type="InParanoid" id="A0A1Y1UI10"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="301" mass="32537" checksum="ED51F24B0A7B91DA" modified="2017-08-30" version="1">MGREADPEEAVEVANLKVNLNWRALRLASQKSLRHFGALSSKRHIGLIGKAETDEVDRETAAKTKNEAVVDNGGVEGHNAETEDAARIKRENGTGDAEDEDEEGEDGLVLKESEVNEAEAADNEPERGDGEINEGEQEVVTRAGSEKPETTGDGEEQLEEPQEGDGMEVDESEAGVNGDELAAAEHEGPNDDDDDAAVDTLTGEMDAPENRGDDEVLPEGEIPVETDQDREGGTTLDDIAEAPSTPPLEENVDAHTDTGETGDQEVEEQEDVEMRVERVPEPTSRYIVDRERGESPLIEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI23</accession>
    <name>A0A1Y1UI23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_393228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871700.1">
        <property type="nucleotide sequence ID" value="XM_022012670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI23"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI23"/>
    <dbReference type="GeneID" id="33554478"/>
    <dbReference type="InParanoid" id="A0A1Y1UI23"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="103"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="228" mass="25431" checksum="069BC4E76F0B63B6" modified="2017-08-30" version="1">MASMLPGLRRGALVSRSTLLPSSTIAFRPLTTSRPVEKPTPISPRDNSPSSSLPATLRAQQGSNQLSLETPRNGAEYVLTTLDKIVNWARQGSMWPMTFGLACCAVEMMHMAAARYDQDRLGVVFRASPRQSDIMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYSVVRGCDRIVPVDIYVPGCPPTAEALLYGMLQLSRRMRRQRQAVRWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI57</accession>
    <name>A0A1Y1UI57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_622944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871689.1">
        <property type="nucleotide sequence ID" value="XM_022015528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI57"/>
    <dbReference type="FunCoup" id="A0A1Y1UI57">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI57"/>
    <dbReference type="GeneID" id="33557337"/>
    <dbReference type="InParanoid" id="A0A1Y1UI57"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="335" mass="39406" checksum="D98EE44BCC4B64DF" modified="2017-08-30" version="1">MSSDAGPSISRVYADVNEGLGKKWYDYEKLSIQWGVQDHYEIVRKVGRGKYSEVFESVHLPSELKCVIKVLKPVKRQKIKREIKILQNLRGGINVIRLLDVVGDNLSKTTSIVFEYVNSTDFKQLYPTLEDQDVRYYMFQLLKALDYCHSKGIMHRDVKPNNIMIDHEKRQLRLIDWGLAEFYHPGTEYNVRVATRYYKGPELLVDFQEYDYSLDMWSLGCVFASIIFRKDPFFHGSDNADQLVKIIKVLGKDDFDIYLERYNIELEGMNISRYPRKPWLKFVTTNNQHLISNEAIRFLDKLLRYDHQERLTAKESQDEPYFSSVKAADGKTQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI59</accession>
    <name>A0A1Y1UI59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_578376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871727.1">
        <property type="nucleotide sequence ID" value="XM_022013317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI59"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI59"/>
    <dbReference type="GeneID" id="33555125"/>
    <dbReference type="InParanoid" id="A0A1Y1UI59"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF55">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="329" mass="36640" checksum="2C7DC9C3928571E0" modified="2017-08-30" version="1">MSQSQAASFTQDVTLGEKNLTDPSLPSAPRKKRVVVTGGSGKLGRWVVREMVEHGWQVLNLDKSAPAPSEKDVPARFIIADLTNYGEVIALLSELDAAYRGIDAVIHLAALPAPGMAANHVIFHTNVTQTYNVLEAARVLRIQNIALASSETVFGIPLNPHLPTKLPLTEEVERPESSYSLSKLLGEKMSEQFCRWDPELKIINIRLSNVIPPEDYGKFQTWQDDPWTRSWNGFGYIDPRDCAQAFRLSLEKPLKGTHVFNIANADSTYTAPTADLVKKVFPTVQYTAETDNPRESLISIKKAREVLGYEPKYDWQSEITKLQGHKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIB7</accession>
    <name>A0A1Y1UIB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_623043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871716.1">
        <property type="nucleotide sequence ID" value="XM_022015543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIB7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIB7"/>
    <dbReference type="GeneID" id="33557352"/>
    <dbReference type="InParanoid" id="A0A1Y1UIB7"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="229"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="382" mass="41125" checksum="36FBE49698DC15D5" modified="2017-08-30" version="1">MKSLLTEEELAIHETAKDYCQSKLLPRVIEAYRTENFDPNILREMGELGLLGATIQGYGCAGVSSVAYGLIAREVERVDSGYRSAMSVQSSLVMHPINAFGSEEQKEKYLPKLATGQLIGCFGLTEPNHGSDPSSMETTATKTADGWTLNGSKTWISNAPVADLFVIWAREVIDGQKGKVRGFLAEKGTPGLSAPAIKNKLALRASITGSVFMEDVKLPADALLPKSGGLGSPFSCLNNARYGISWGVMGALEDCIARSRDYALERKQFGKPIASFQLVQKKLADALTATTVGLLGSLQLGRLKDSGKWAPDMVSMMKRNNTSMALQHSRILLDILGGNACADEYHLGRHVANLQVTATYEGTHDIHTLILGKSITGIAAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UID8</accession>
    <name>A0A1Y1UID8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_578959</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871810.1">
        <property type="nucleotide sequence ID" value="XM_022013349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UID8"/>
    <dbReference type="FunCoup" id="A0A1Y1UID8">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UID8"/>
    <dbReference type="GeneID" id="33555157"/>
    <dbReference type="InParanoid" id="A0A1Y1UID8"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="7"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="227"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="317" mass="34235" checksum="6C16777E124BFA7E" modified="2017-08-30" version="1">MPASRCLVRGSINIDEFFHLPHIVRPGETISSTDFARKPGGKGANQSYAVAKAGGQVDLDGCIGQDGTWVKEYLEAGGVDVHRLQVLKDEVTGRAIIQILHKGANFYAPSEPQQLDLSSYTHLLLQNEIPLPITLEHLTTAASHSITTVFNPSPMLSTSELRSFPWDSLSWLIVNEGELADLLSALGSSTSRPSSSEGENLRGKAEEDLRLLHENQHFSSSTSIICTLGAQGIIYFQPRSNLPVNMGHLPAAKLQKPVKDTTGAGDCFAGYFVAGLMAGLELEEVLRICLTACAICVESAGAMESYASRDEVLKRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UII8</accession>
    <name>A0A1Y1UII8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_444665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871405.1">
        <property type="nucleotide sequence ID" value="XM_022012800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UII8"/>
    <dbReference type="FunCoup" id="A0A1Y1UII8">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UII8"/>
    <dbReference type="GeneID" id="33554608"/>
    <dbReference type="InParanoid" id="A0A1Y1UII8"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000049">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.14, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="303" mass="32387" checksum="B2ED01FFB6DFDD35" modified="2017-08-30" version="1">MVNNTEYYKVLGISKDASEADIKKAYRKAALASHPDKAAEGQRDAAEAKFKKIGEAYEILSDSNKREIYDQLGEEGLKGGRGGGMGGMGGMPGMGGMGGMGGMGGMPGGFDDGSSSGLPPPGEIVKPLALSLEELYRGGTKRLKITRNLRTGGQEEKILEVAYKAGWKAGTKIKFAGSGNEDEYGQAQTVAFVVEEKKHNRFERQGDDLIISLNISLSQALLGPDGGGTISKEIEQLDGRRLKVSPPEGIVQPGSETRIQGEGMPVSKANSTKRKGDMIVRWNVVFPSRLTPSQKSELRKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIS9</accession>
    <name>A0A1Y1UIS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_626010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871434.1">
        <property type="nucleotide sequence ID" value="XM_022015862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIS9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIS9"/>
    <dbReference type="GeneID" id="33557671"/>
    <dbReference type="InParanoid" id="A0A1Y1UIS9"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="528" mass="57384" checksum="622BBECC737E6E0D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU6</accession>
    <name>A0A1Y1UIU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOM core complex subunit Tom6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871886.1">
        <property type="nucleotide sequence ID" value="XM_022015618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU6"/>
    <dbReference type="GeneID" id="33557427"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU6"/>
    <dbReference type="OrthoDB" id="5514856at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7743" checksum="DB2F44D43FE70E93" modified="2017-08-30" version="1">MSAPQPVNPLYLGSSKRPAQSGNPLADFWRTQVVAPEYRAENLRILRAATVFIVGVAFVRSNLSSALVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU7</accession>
    <name>A0A1Y1UIU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_623975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871948.1">
        <property type="nucleotide sequence ID" value="XM_022015649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIU7"/>
    <dbReference type="GeneID" id="33557458"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU7"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="67582" checksum="C289E0C3CD320038" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJB8</accession>
    <name>A0A1Y1UJB8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_679922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872075.1">
        <property type="nucleotide sequence ID" value="XM_022019058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJB8"/>
    <dbReference type="GeneID" id="33560867"/>
    <dbReference type="InParanoid" id="A0A1Y1UJB8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF33">
        <property type="entry name" value="SUGAR PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="554" mass="60592" checksum="3A3637D59BA27991" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJY3</accession>
    <name>A0A1Y1UJY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872285.1">
        <property type="nucleotide sequence ID" value="XM_022015298.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJY3"/>
    <dbReference type="GeneID" id="33557106"/>
    <dbReference type="InParanoid" id="A0A1Y1UJY3"/>
    <dbReference type="OrthoDB" id="2563277at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1093"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1714"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1927"/>
            <end position="2000"/>
        </location>
    </feature>
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            <end position="73"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="1324"/>
        </location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1863"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1935"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2000" mass="216157" checksum="3EEC3C657F59D18F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK36</accession>
    <name>A0A1Y1UK36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_623461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871813.1">
        <property type="nucleotide sequence ID" value="XM_022015584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK36"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK36"/>
    <dbReference type="GeneID" id="33557393"/>
    <dbReference type="InParanoid" id="A0A1Y1UK36"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35987" checksum="18E1C65A6182D366" modified="2017-08-30" version="1">MNANMTAAELTEHPAQIPQALDNPFPYGPEVEASKSAPYSSKKSALAFFLQATGANDVKELEAKSRSLQEEAYKLWPYPCIRRWSFLSTKNAEHPIYERILKLGTESNAIFLELGCFFGTDSRRLTYDGWDPSRIVGTDLRPEWFEKGYELFSDKSTCEIKFIPGDIFDSALLPTSFESGSSATIDVETLKSLNSLAPLQGHVRAMSAFSFFHLFEEQGQFELAKRVATLISPKKGSIIFGAHQGGIKKGSLSRANSHDPNATRFVHSPESWVDMWETEIFPSSRDSSVSDGSIRVKATAKLVERSGPIQPNSTSTMGWIIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL92</accession>
    <name>A0A1Y1UL92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_349311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872249.1">
        <property type="nucleotide sequence ID" value="XM_022012550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL92"/>
    <dbReference type="GeneID" id="33554358"/>
    <dbReference type="InParanoid" id="A0A1Y1UL92"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="311" mass="33850" checksum="58AE7F8E91ABC644" modified="2017-08-30" version="1">MMIRGVVESSGLVRICIRCPRIHQFNASSSSHASQWRSVPLSSPSQSYGYSRRSFATSDVAFFPESEAERFGLGLSPRAQGSPQRPQPQARYARGRNERFSQEGKSAVPSSSRKPPGRTSKDPLDSQGPRRPSPLGDGPRASLDGPDSALRGIQPGSGLPAHRPGHDRSQPNSAQVGQRDPANRSGDPSYANDTRTGRSSGSDPGLMKRVEKSSPRLPFTRASESGLTKSLNNKESIRRTVKERSPPAVRLDGLAGELMLRGMASDTLAEALNTSEEHYTHRHLGRKVDFSNMPRQPKFKDGQKNVLTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULE5</accession>
    <name>A0A1Y1ULE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HbrB-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872228.1">
        <property type="nucleotide sequence ID" value="XM_022015275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULE5"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULE5"/>
    <dbReference type="GeneID" id="33557083"/>
    <dbReference type="InParanoid" id="A0A1Y1ULE5"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="515" mass="54968" checksum="4C423846A895C533" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULK9</accession>
    <name>A0A1Y1ULK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872794.1">
        <property type="nucleotide sequence ID" value="XM_022014963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULK9"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULK9"/>
    <dbReference type="GeneID" id="33556771"/>
    <dbReference type="InParanoid" id="A0A1Y1ULK9"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011833672" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="521" mass="57063" checksum="E9BE65B26185B2C2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULX7</accession>
    <name>A0A1Y1ULX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_307400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872913.1">
        <property type="nucleotide sequence ID" value="XM_022012446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULX7"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULX7"/>
    <dbReference type="GeneID" id="33554254"/>
    <dbReference type="InParanoid" id="A0A1Y1ULX7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37628" checksum="5A8493E36BEAE502" modified="2017-08-30" version="1">MLITVLTRSAPTTLRRLSTFTPFQPLVKMVAPAGLFSNRYKLEDMPDLSGQVAIVSGGTRGIGEAVSAALVQKGCEVHILSATEEHFKEAVEHISADTPSAPSLLKYHQIDLHSLKSLAGVIPELAKLPRIDMLYLIAGIGVAPFQLTEDGIGNHFAVNNLSQMMLVDGLLDKIKETARGKTGEDKWSTRIVSESSELHRAAPSEAKFANLAEMSEDSKDMDPTKLYGRSKLANALFIRELSKHLPPLTSDEPILAISVHPGAVATEQQQGATQAYGFIPGAESALWAGTGKTASERREEVQGRYFSEADGKVDTESDQAKDDALAKQLWELSVKTLKDKAGYEVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM73</accession>
    <name>A0A1Y1UM73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_618489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872955.1">
        <property type="nucleotide sequence ID" value="XM_022015032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM73"/>
    <dbReference type="FunCoup" id="A0A1Y1UM73">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM73"/>
    <dbReference type="GeneID" id="33556840"/>
    <dbReference type="InParanoid" id="A0A1Y1UM73"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="141" mass="16500" checksum="C50A5D7B0513AEE7" modified="2017-08-30" version="1">MARMAGRPQTFDEMYSVPESFLEIEVSKPMTHGAGRKMYTDYEITCRTNIPAFKLRHSIVRRRYSDFEAFRDILERESTRVNIPPLPGKVFTNRFTDDVIEQRREGLQRFLEVVAGHPLLQTGSKVLCAFLQDPSWEKSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMI5</accession>
    <name>A0A1Y1UMI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872626.1">
        <property type="nucleotide sequence ID" value="XM_022018085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMI5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMI5"/>
    <dbReference type="GeneID" id="33559894"/>
    <dbReference type="InParanoid" id="A0A1Y1UMI5"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="280" mass="30647" checksum="06F64BC4A02C25AD" modified="2017-08-30" version="1">MLSKPTILVIHGSWHVPAHYEPLVQSFKSQGFEAVCPRLPSFAAKPHIGLREDVRAIQAALEELVEAGQDILVLAHSYGGVVTSQAVTREYDVQTRMVKGLKGGVVGLVFMATFLPLPGESLADALGSSLPPFLPIHPDGSCTMLDPAQAFYHDVPSDQAQHWISLLKPCPAITQFSAITDASYLSYRSTYIYATDDQRLPYPIQKWMVKRASLLGARFNEKEVKSSHSPFLSMPKKIVECVQAEIDNGVYAVDPAFVDAAEAVRREFGEILAKMGPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMU8</accession>
    <name>A0A1Y1UMU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872377.1">
        <property type="nucleotide sequence ID" value="XM_022015337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMU8"/>
    <dbReference type="GeneID" id="33557146"/>
    <dbReference type="InParanoid" id="A0A1Y1UMU8"/>
    <dbReference type="OrthoDB" id="2564972at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="64462" checksum="FD186ACDD8A6DAB0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNE0</accession>
    <name>A0A1Y1UNE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_606901</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873365.1">
        <property type="nucleotide sequence ID" value="XM_022014036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNE0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNE0"/>
    <dbReference type="GeneID" id="33555844"/>
    <dbReference type="InParanoid" id="A0A1Y1UNE0"/>
    <dbReference type="OrthoDB" id="2596127at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="14">
        <location>
            <begin position="85"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="259"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX39580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="387" mass="42435" checksum="CBAB725B069BE705" modified="2017-08-30" version="1">MASLDSDKSGESSRRPVPTRTLDNPSRLTVAQRLGPRGTAAEESSSTDADTLAHSLLNRVKITKKGERWSDKLMEEAVDIKTFKKACGYLTPRQYLDVLHERHLNGLCSYPTCSNAPLHPYTSHRRFKISTSNRTIREKQGNEEEGYCSDKCRLRSGWVEQKLSEVNVWDRAGKVGVIELLEDLEDQNSTTAQRTKQAPPICAGQPQASPTRSYEAAQPTEPIQPWKERIQTVALNSSTSSSPSSIADMISSLTIIERPSQSISSAPTDCPPTTNGPLSKSKPTPPGASLPTSEVEVSDPDPLTHTSRRNTSSLVSTPGNLTSSVLSASRQMGPIPQLDPDSEDEEVEQGDWGESEMGLDWGDETDEMKALFEEARKARDLLVEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNV9</accession>
    <name>A0A1Y1UNV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_618676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873019.1">
        <property type="nucleotide sequence ID" value="XM_022015064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNV9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNV9"/>
    <dbReference type="GeneID" id="33556872"/>
    <dbReference type="InParanoid" id="A0A1Y1UNV9"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="552" mass="61278" checksum="CC9802491C9CA756" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP07</accession>
    <name>A0A1Y1UP07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_618976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873107.1">
        <property type="nucleotide sequence ID" value="XM_022015104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP07"/>
    <dbReference type="FunCoup" id="A0A1Y1UP07">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP07"/>
    <dbReference type="GeneID" id="33556912"/>
    <dbReference type="InParanoid" id="A0A1Y1UP07"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="365" mass="39432" checksum="5B72FC96E14DE1A0" modified="2017-08-30" version="1">MTHVPVHVEVKEPKAGGEKSKKMHSQVVIIGSGPAGHTAAIYLARANLNPVLYEGMLANGFAPGGQLTTTTDVENFPGFPDGVRGPEMMDKFRLQSERFGTKIITETIVRVDLSQRPFKYWTEGEEEEQDFMTADTIILATGASAKRLNLPGEDTYWNSGISACAVCDGAAPIFRNKPIAVIGGGDSAAEEATYLTKYGSHVYVLVRRDELRASKIMAKRVTTHPKVTVLWNTVAVETKGDGDLLQSLVVKNVKTGETKDLPVNGLFYAIGHEPATALVKTQVQVDEDGYIQTVPGTAQTSIKGVFAAGDVQDKRYRQAITSAGSGCMAALEAERLISEEEAEDENIPTDKVHVPTEGYMGADKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP28</accession>
    <name>A0A1Y1UP28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_234893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873576.1">
        <property type="nucleotide sequence ID" value="XM_022012243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP28"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP28"/>
    <dbReference type="GeneID" id="33554051"/>
    <dbReference type="InParanoid" id="A0A1Y1UP28"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="541" mass="58768" checksum="C58D95E65119ABB2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP78</accession>
    <name>A0A1Y1UP78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ploidy maintenance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_619256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873187.1">
        <property type="nucleotide sequence ID" value="XM_022015151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP78"/>
    <dbReference type="FunCoup" id="A0A1Y1UP78">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP78"/>
    <dbReference type="GeneID" id="33556959"/>
    <dbReference type="InParanoid" id="A0A1Y1UP78"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="251" mass="28278" checksum="1F49F83294418F36" modified="2017-08-30" version="1">MSSFLNSIGRLRAPKRSPNQTPTAGNGFFDPPSPGAELTGSPPSPSSAPKPLYLCQPFVKAALVKGSFKTIVAPPKYVDVNEWVAVNLFDFYHNLNHFYGVLTEFCTLNNCPTMSAGPTLNFLWPDQNQRLVSLPAPTYIDFVMSWLQKLLDDETVFPTKSGREFPSSFAYTAKHIYKHLFRIFAHLYHAHFEQIIHLSIEAHFNSLFAHFLAFGKEFDLLVMQDLMTQQGMGQGVAELGEKWRDMGILET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPA3</accession>
    <name>A0A1Y1UPA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872818.1">
        <property type="nucleotide sequence ID" value="XM_022014976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPA3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPA3"/>
    <dbReference type="GeneID" id="33556784"/>
    <dbReference type="InParanoid" id="A0A1Y1UPA3"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45174" checksum="418CF931C971DF07" modified="2017-08-30" version="1">MSSIVAGPGPETPLPLSPLKQLPTMAPSPSVKRHNDPFLDSASKRSKLSSTPLKMPAIPTRALTPSTSTAAYSSSPRRLDSSPTAANVQPIKHVRIKDIAMEPVTVTPGMAIVFGRHRHTHDANRTTELRSTVPPHLRHLVSDIDSPATVVYLPRFARHASRVHAVVEYLEDNDVLRVVVVGQNGLRLSDGHRILPGQRFDLHREDELEISFYGAAVHLGFPHETRERLFSPESEASSPQSSLPPSSPPLRRGSSPLSEDEISTAAMVLESKPSVSPRIGGPDIDSTLPLPAGTDLPALLASTVVFSGSSKLSLPDLVKHMLESQPSLREQGSESQWEHWCSGVLDKNAMFGKVQRHGKDASGRPLLPHYFYNPDLDTDLSRAKELGGLVRPLRTVQRAGGKAIDWRPVGGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPH5</accession>
    <name>A0A1Y1UPH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873229.1">
        <property type="nucleotide sequence ID" value="XM_022015170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPH5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPH5"/>
    <dbReference type="GeneID" id="33556978"/>
    <dbReference type="InParanoid" id="A0A1Y1UPH5"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="405" mass="46421" checksum="4D3F636E0C818D03" modified="2017-08-30" version="1">MSYRLLERDEAPDPLLPTSSTPTRTTKTLPKWARLLPRGRSRSRWIILALTALFVLAVLNHRALGTWRRDFVYLIRPLWDTPEPPFHIIPHYASPTADDTTGWCALHGWTPRPTDPRTGHGQVKIVDAVLLSSELDMLEIRMREYLPYVTTFVIVEADRTFSGEPKPLYFDQNRFNTIIKGCPGTTIEYHVIRDLQPDQPVGSFDNEIKMRRAVSEVLASLDLPAGSLVIQSDVDEIISWQTLDLLTTCQGFPQTLHLNVKNYRYDFAHPIPDEGYWRPHVYTTQTDHEGVGYYHGRGSNELLAGAGWHCSFCFATLDEMRAKMRGYSHNDRLRDPSLLDTLRSRVCDGRDPFNMWPEAFTFKDIFAQSGRLAKSLVYTDTPSAVQEFPERFAYLLDKGCERPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPN0</accession>
    <name>A0A1Y1UPN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873279.1">
        <property type="nucleotide sequence ID" value="XM_022017999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPN0"/>
    <dbReference type="FunCoup" id="A0A1Y1UPN0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="33559808"/>
    <dbReference type="InParanoid" id="A0A1Y1UPN0"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="137" mass="15183" checksum="5E8D833D545D6E89" modified="2017-08-30" version="1">MLFHLSAFSVILIIVLGAFYYRNRLAPMARVVIPYLPTPLAARLSNYTPLTTFSFSDQAAAGISSRNFDLEENIGEGSGENRVGLDQAGVEEVRRIMAIERCTFDQARLIRHNRILAKNGIAPDGTPMDKKAITRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPY6</accession>
    <name>A0A1Y1UPY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873068.1">
        <property type="nucleotide sequence ID" value="XM_022017966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPY6"/>
    <dbReference type="FunCoup" id="A0A1Y1UPY6">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPY6"/>
    <dbReference type="GeneID" id="33559775"/>
    <dbReference type="InParanoid" id="A0A1Y1UPY6"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="151" mass="16933" checksum="B79F66EE51AF2DA0" modified="2017-08-30" version="1">MAKIPRSFRLLSELEHGEKGIGDGSCSYGLKDPDDIAMYGWNGTILGPPHSAYENRIFSLSIYCGDTYPDTPPIVKFESKINLPCVDQTNGLVNFSRVASISSWKRDFTLETVLVELRRDMASPANRKQPQPPEFSEFPPLDLAKLAKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ07</accession>
    <name>A0A1Y1UQ07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_616222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873874.1">
        <property type="nucleotide sequence ID" value="XM_022014806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ07"/>
    <dbReference type="GeneID" id="33556614"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ07"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="176" mass="19645" checksum="319DCE6B68134509" modified="2017-08-30" version="1">MSGHPPLPNWLYNEANLVTHQPRARDPMRPSVEATDSSCSTRSSRSFQTIRFMFDPLRLRGGCSVNGSCDCLEDPVEKDRKKMQIHTQPPHWRQSDLGTRSIELDTRSRRTSFSVPQHRIDHITDPLSRAQTHQTDRSVNLGLRQALKDDPAFGTIDATGFPPGSTSPATGRASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQA8</accession>
    <name>A0A1Y1UQA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_587434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874006.1">
        <property type="nucleotide sequence ID" value="XM_022013754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQA8"/>
    <dbReference type="FunCoup" id="A0A1Y1UQA8">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQA8"/>
    <dbReference type="GeneID" id="33555562"/>
    <dbReference type="InParanoid" id="A0A1Y1UQA8"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="130"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="437"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="745"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="879"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1196" mass="134982" checksum="216DF82BBF55F921" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQP9</accession>
    <name>A0A1Y1UQP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition motif 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_648429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873589.1">
        <property type="nucleotide sequence ID" value="XM_022017838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UQP9">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQP9"/>
    <dbReference type="GeneID" id="33559647"/>
    <dbReference type="InParanoid" id="A0A1Y1UQP9"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Mei2-like C-terminal RNA recognition motif" evidence="3">
        <location>
            <begin position="539"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="712" mass="78360" checksum="3DCF55DF64202C34" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR54</accession>
    <name>A0A1Y1UR54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative signal transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_647391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874138.1">
        <property type="nucleotide sequence ID" value="XM_022017646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR54"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR54"/>
    <dbReference type="GeneID" id="33559455"/>
    <dbReference type="InParanoid" id="A0A1Y1UR54"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="207" mass="23017" checksum="256F93BC1EA988D0" modified="2017-08-30" version="1">MSDRGGPTRRPDIKRKLVVVGDGGCGKTCLLTVYAENRFPEQYVPTVFENLITMIPSPTDPSKIIELALWDTAGQEDFDRLRPLSYNDTDVILIVFACNHRPSLMNVQDKWYPEMAHFCESVPLVLVCTKTDLRNDPTTVSLMAAQGTTPITPLEGEKVAKEIGARRYLECSAKEGRGVREVFDAAIRESLRKGGLGKLGKKKCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR59</accession>
    <name>A0A1Y1UR59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_647399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874148.1">
        <property type="nucleotide sequence ID" value="XM_022017649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR59"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR59"/>
    <dbReference type="GeneID" id="33559458"/>
    <dbReference type="InParanoid" id="A0A1Y1UR59"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="349" mass="37991" checksum="B4A0AEB0FDF617D6" modified="2017-08-30" version="1">MSRNIRQMTSSNRNLGPAGALGSASKGAPDILPSLFSTTIHHDIDNPTCPALAVARVGGTGGQIYVYSDEPVDSVSGPPRGVRDSLMSYLLSCSHPATVKQDSRIHQPVPQDHHTLPLTPPSSYTPNVNIPQASAVVNHLDRRQSLPLTPDSIPTDEPMIQSLPSPQTCPSPPPRMTTHVSIQLVNDLFPRQASQFDTCTHALEIVTPPDHITQGFILDHQLYGRSVYIHLRPPHSASDRPEDLSANFSEVLRPHDPSRMRGTSPDDDLAESQALDIRESLTALLDLASDSLDAKNLILVLDKSDRDLGGLDELLHSLMFVGGQVVRPGLLEGGWDWDSNRWVLVGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URC2</accession>
    <name>A0A1Y1URC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_648759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873942.1">
        <property type="nucleotide sequence ID" value="XM_022017879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URC2"/>
    <dbReference type="STRING" id="4999.A0A1Y1URC2"/>
    <dbReference type="GeneID" id="33559688"/>
    <dbReference type="InParanoid" id="A0A1Y1URC2"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="57"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="253" mass="28304" checksum="F63AF56CAFB401BE" modified="2017-08-30" version="1">MVDATQAVPQKSLKQWHSPDSRQEVIHELIHGVDRYNPSNLPYMEEYLSSQIKDGEYDLLANLAILKLYQFNPQMSNPEVIINILLKSLSATVHGPDFNLCLSLLREPAAILHDIESDEQSLITVMPLLQELHTLLRTCQFTAFWKTLNGDEEGAQILRQQYLPQQPHLESSLRILIATSIASCFSRVPIARLSNWINLSSSDLSSWSESIGWKVEGDVAVVPKNGDNDVKAGVVKESVELNQLTKLVSAAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URE9</accession>
    <name>A0A1Y1URE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_5466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874191.1">
        <property type="nucleotide sequence ID" value="XM_022013012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URE9"/>
    <dbReference type="GeneID" id="33554820"/>
    <dbReference type="InParanoid" id="A0A1Y1URE9"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="285" mass="31961" checksum="C2E1FDF9AD5D990F" modified="2017-08-30" version="1">MNRRIAPSAKCFDLHLSRPHLLIVHSLMTLIALGSNVFGNLDPTSQNEILSPTDITVKTGCEKVIWHSFTLTVGRDKFVYTLDGRRSKNEWNDVVVTGLGGVYAWYKDSIYMCDQMEAFLEAAHDEPTLTHPLLATSKGKLYAAESRVFLVLDGPAQHLFEIDHGDLRQNAAPRLRLIEEFEGLRFTFISGTRNRFGVVTEAGDFYLIDTRSKDPELVELAEEVRLAGVGSRFEVVVTETKVLTRDLNLGETEVQHSPTWVEVDIDPKSIQAIHTSRSTVIFDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URK9</accession>
    <name>A0A1Y1URK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ferric reductase like transmembrane component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_616417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873909.1">
        <property type="nucleotide sequence ID" value="XM_022014826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URK9"/>
    <dbReference type="STRING" id="4999.A0A1Y1URK9"/>
    <dbReference type="GeneID" id="33556634"/>
    <dbReference type="InParanoid" id="A0A1Y1URK9"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="354"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="11">
        <location>
            <begin position="687"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="815" mass="90636" checksum="49AC8055621D35E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URN0</accession>
    <name>A0A1Y1URN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_611575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874308.1">
        <property type="nucleotide sequence ID" value="XM_022014282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URN0"/>
    <dbReference type="STRING" id="4999.A0A1Y1URN0"/>
    <dbReference type="GeneID" id="33556090"/>
    <dbReference type="InParanoid" id="A0A1Y1URN0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012914669" evidence="2">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="217" mass="23698" checksum="F5C0F0BC68BDE84B" modified="2017-08-30" version="1">MTQSLLFLVLGATGGTGKHFVTQCLRDGHRVRALVRTPSKLPSEAADKIEVVQGSITDNVDTDALVKGVDYVVAMLGDKETQQTRKVCLEFVQKLVPSMRENGVKRFLFQAGGLSRPYGGSLTPLLWFLRYTLAYAGGFHGQHLDNEAVMEYLSTQAMDIEWIVHRAGIGSDGPSKGKLARSPSTFSIGTHVDCATYSFDLVQDASAVHTSDFSHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URU7</accession>
    <name>A0A1Y1URU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_616983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874019.1">
        <property type="nucleotide sequence ID" value="XM_022014868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URU7"/>
    <dbReference type="FunCoup" id="A0A1Y1URU7">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URU7"/>
    <dbReference type="GeneID" id="33556676"/>
    <dbReference type="InParanoid" id="A0A1Y1URU7"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="64" mass="7428" checksum="E44B365CEB3D8B06" modified="2017-08-30" version="1">MHLMYTLDEQGNRVYTLKKITKDGKVSKSAHPARFSPDDKFSRHRVTIKKRFGILPTQLPSKPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US87</accession>
    <name>A0A1Y1US87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="12">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_647794</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874569.1">
        <property type="nucleotide sequence ID" value="XM_022017717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US87"/>
    <dbReference type="STRING" id="4999.A0A1Y1US87"/>
    <dbReference type="GeneID" id="33559526"/>
    <dbReference type="InParanoid" id="A0A1Y1US87"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="16">
        <location>
            <begin position="62"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX40890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="479" mass="53711" checksum="C70EBFA1DBBA309D" modified="2017-08-30" version="1">MASQNATVTSSSAASSAARDKQKTKIWWSNGIFFIFMHAFALYGVLYLSPLKDLDRRTAILAIMSWQIPCFGITLGYHRLWSHHAYEATLPLRIVLAALGSMGFQGSIKWWVLRHRLHHRFTDSPIHDPYAATKGLFYSHCGWIFLKPSYPRLRLIERDDLDSDPVVRFQHKHFLPIAILMGIAVPWAVAYLGWGDGWGGLVWGAIVARLGVWHSTFCINSLAHWSGFQQFTEDVSARGNLILALITSGEGNHNYHHAFPQDFRNGPHSGDWDPTKWIIWLLHNFTPLVPKIYRTPDSAIASAKARVLMAHADRLYATVPQEEREKPIEELPVWSRAEVKKRHGELVVRHVQEGDGTVESIRWRRLLLIVDGCIVDAGRFLPDHPGGKQLLLAHAVTTLPASHFDSLESSLSSPTSPAMSDSGDSFPFTDSGYTSGDHDDNDKLILRDATKAFFGGMNNHTGAAKAQMRSLRVARLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USG1</accession>
    <name>A0A1Y1USG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_678307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874571.1">
        <property type="nucleotide sequence ID" value="XM_022018984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USG1"/>
    <dbReference type="FunCoup" id="A0A1Y1USG1">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USG1"/>
    <dbReference type="GeneID" id="33560793"/>
    <dbReference type="InParanoid" id="A0A1Y1USG1"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="279" mass="31383" checksum="CADA23EF1741471E" modified="2017-08-30" version="1">MRHKRAKVYKRAMGIYTQAFNFRQPFQILVSQDILLSLNKESDIHKQLFACVQGNVKPMITQCCIDALYKKGRDYQPLVDIAKTFERRKCNHREVIEPDECLKDVIGQTNKHRYVLAAQSVKLRTSLSTIPGLPMIHFNPRGVLVQSPPSRATLKYKDAMEEERRTEGARVLDGIVDGDNVLGAAQIDGGQRAVAGPSSSGQPRRNRIKGPNPLSVKKKKRKAPDDQAETATKRKSSEPRDVQVEGSDDVRKKKKRKRRGKGEVALAIEEIRAGQMADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USK9</accession>
    <name>A0A1Y1USK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="1">FBP aldolase</shortName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874679.1">
        <property type="nucleotide sequence ID" value="XM_022017736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USK9"/>
    <dbReference type="STRING" id="4999.A0A1Y1USK9"/>
    <dbReference type="GeneID" id="33559545"/>
    <dbReference type="InParanoid" id="A0A1Y1USK9"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="31558" checksum="13F06319015F92F8" modified="2017-08-30" version="1">MSLENNLTLSILAKAENEGYGILAQACYDASMAVGLVRAAERARSPAILQIFPITLEYAGAPFLRFLVDLAHSASVPVSVHLDHATTAEALEVAIGLAEKQGIKFDSIMVDASHADTDEENISIAVPFIKRCNAQGISTEVELGRLEGGEAGVREITGEMLTDPSKAEVFMKQTGANILAPCVGNRHGSYKTFGGPQWKMDLLETLCKQFKGRVPICAHGTDELPEHYWTDMIKLGVTKINVNSWCRDPYAAKLSSGLASKPFPEAQEEATEHFAKECEKWMKLFGSAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT79</accession>
    <name>A0A1Y1UT79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_613676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874899.1">
        <property type="nucleotide sequence ID" value="XM_022014528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT79"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT79"/>
    <dbReference type="GeneID" id="33556336"/>
    <dbReference type="InParanoid" id="A0A1Y1UT79"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="381"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX41220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="789" mass="87105" checksum="E6EE0F29AB484A3F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTZ4</accession>
    <name>A0A1Y1UTZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_612499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874575.1">
        <property type="nucleotide sequence ID" value="XM_022014395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTZ4"/>
    <dbReference type="FunCoup" id="A0A1Y1UTZ4">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTZ4"/>
    <dbReference type="GeneID" id="33556203"/>
    <dbReference type="InParanoid" id="A0A1Y1UTZ4"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="62"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="587"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="791" mass="85098" checksum="569C3E677EAB8FB3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUC1</accession>
    <name>A0A1Y1UUC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_612106</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874464.1">
        <property type="nucleotide sequence ID" value="XM_022014352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUC1"/>
    <dbReference type="FunCoup" id="A0A1Y1UUC1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUC1"/>
    <dbReference type="GeneID" id="33556160"/>
    <dbReference type="InParanoid" id="A0A1Y1UUC1"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX40785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="109" mass="12635" checksum="0C05A147309B442D" modified="2017-08-30" version="1">MSKNPYANNSQLSSLEQEVLWEYVKLSDKIKRISNLAKETAETPNESLLTELRDLEKKMGLVLTLFKASVWTVVNDREAELAAKVAQEQAGRYQPQDYEEEDSLEQEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUJ3</accession>
    <name>A0A1Y1UUJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_614018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874976.1">
        <property type="nucleotide sequence ID" value="XM_022014554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUJ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUJ3"/>
    <dbReference type="GeneID" id="33556362"/>
    <dbReference type="InParanoid" id="A0A1Y1UUJ3"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="301"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="490" mass="53706" checksum="024CD6FCCFD7D612" modified="2017-08-30" version="1">MAAVPPVANPLGPPKRHRGNRLGERRLQRDGSSRDASEEDNDEAASDVGSLMSIPAPPEGNSTTAPGTLPSSSASPRPGPPQALPIPIQLMNQGQASHSHSARRGSAPHAIARRVEEVSGEELSGLDSPTYDGDVESASTVGGTPVHHSVLSSHQYHHQRQTSSPIAGMPADAPGQSTLSPYGQKVPTPKASRVNLVDEPEYTAIGIDSFGRSPPFVPPSDVPVARSDSLAEATKSQTLPLSRKPSRSMGPPKMMTRPKELPIEDIRAFVQRAIDGKGEEDGIQRWWKTKAPEEGRVVRVYADGVYDLFHFGHALQLRQCKLSFPRVHLLVGVCSDDLCATHKSAPVMTHAERCEAIRHCRWADEVLPDAPWVVTQEWMDKHQIDYIAHDEELYPSKDYDDVYEFAKEQGAFVPTRRTPAISTSDLLERIVRGYRDGFFDSKLEKNGLSELMASDVDWDSSPSRSRAQSKEGRKRDLLEIATTHAAIEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUW3</accession>
    <name>A0A1Y1UUW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874945.1">
        <property type="nucleotide sequence ID" value="XM_022014545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUW3"/>
    <dbReference type="GeneID" id="33556353"/>
    <dbReference type="InParanoid" id="A0A1Y1UUW3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="656" mass="72158" checksum="C21C7709E021B1F0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5G6</accession>
    <name>A0A1Y1U5G6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_640321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867628.1">
        <property type="nucleotide sequence ID" value="XM_022017333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5G6"/>
    <dbReference type="GeneID" id="33559142"/>
    <dbReference type="InParanoid" id="A0A1Y1U5G6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="68" mass="7261" checksum="C8DC0040DFE4428C" modified="2017-08-30" version="1">MFNFCQACSSQLSPLPQATHSMVGNGQMTLMPTYLSYLMCVSCNCSQHSDNCPGHSSICSVPAKSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U636</accession>
    <name>A0A1Y1U636_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_643908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867828.1">
        <property type="nucleotide sequence ID" value="XM_022017576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U636"/>
    <dbReference type="FunCoup" id="A0A1Y1U636">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U636"/>
    <dbReference type="GeneID" id="33559385"/>
    <dbReference type="InParanoid" id="A0A1Y1U636"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="209" mass="21243" checksum="5C51C98EF40CC2FC" modified="2017-08-30" version="1">MGSTTANGSTSAPSSTLTPSSPSSSYPSALPSASDTLSGAYADPASLHPLAGLGKNLDFLQLEEDKLQNVEGAMNVLPSRGWTDDLCVGTGTTYVSGLAVGGVWGLKEGLGRQLGPNPAFKLRLNSVLNAATRRGTLLGNSLGVLAMFYNIANSSLDSIRGKHDVFNSMGAAALSGAVFKSTSGMRPAAMSAGLMASAAGAWSGFKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6G3</accession>
    <name>A0A1Y1U6G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_216687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867911.1">
        <property type="nucleotide sequence ID" value="XM_022012200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6G3"/>
    <dbReference type="GeneID" id="33554008"/>
    <dbReference type="InParanoid" id="A0A1Y1U6G3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011988054" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19184" checksum="724BC3E713B34C04" modified="2017-08-30" version="1">MVQIVRLFLLSLAAVGTQAYHKRSHGHAPSPAASQDLKLATRDGIVKRGEALKRGDIRPRGTTASYPDCSGFHSTLTTNDHAVYYNTPLTVGYAHSRHESCFKDCLAACCSLSTCTAASFDPTESHGHKNCFLYDDKDASVFNYGTDSHYTLAINRRTCAHNAANGKQAGPSESAECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U764</accession>
    <name>A0A1Y1U764_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_595343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868169.1">
        <property type="nucleotide sequence ID" value="XM_022013845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U764"/>
    <dbReference type="STRING" id="4999.A0A1Y1U764"/>
    <dbReference type="GeneID" id="33555653"/>
    <dbReference type="InParanoid" id="A0A1Y1U764"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="853" mass="94091" checksum="9464841EF84665D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7F2</accession>
    <name>A0A1Y1U7F2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_653637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868226.1">
        <property type="nucleotide sequence ID" value="XM_022018682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7F2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7F2"/>
    <dbReference type="GeneID" id="33560491"/>
    <dbReference type="InParanoid" id="A0A1Y1U7F2"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="31"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="263" mass="29115" checksum="93B5DEBC4F6E68E4" modified="2017-08-30" version="1">MRTIRSALKYPPKHSPADCPPHTVEVGARPPSEAAILLPLMNIQGEPCILLSRRSEKLRVHAGEVSFPGGKADPTDANLAAAAMREAEEELGIPVENVELLGMLEPPEYSLGNRARVWAFVGFVHDRPFDILNSATQFRSQKVGPLTSLSLSDLKPSTSEVSGLIPFPLFLLADKESDRRSLHFFRMDPGKPYWKYKVGDLFVNTDGTGQSIEGLRSDKCEVWGLSGWFLHRLLKRMGLTEDPVMAQIRSETGTETQGNLTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7G4</accession>
    <name>A0A1Y1U7G4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BIR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_637770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868236.1">
        <property type="nucleotide sequence ID" value="XM_022017046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7G4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7G4"/>
    <dbReference type="GeneID" id="33558855"/>
    <dbReference type="InParanoid" id="A0A1Y1U7G4"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000016">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="598"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="484"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="71430" checksum="0A61B757CE726A2E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Q6</accession>
    <name>A0A1Y1U7Q6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_195136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868357.1">
        <property type="nucleotide sequence ID" value="XM_022012149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Q6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Q6"/>
    <dbReference type="GeneID" id="33553957"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Q6"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="298" mass="32835" checksum="FF261DE4FE20908B" modified="2017-08-30" version="1">MGSMQSLSLQDPPNANETLINSDASTQPPTAANAVQAPVPTPSLPSIARSLFPPKFVSAVSDLLYNRLPPELIPLILEYAAYYSESNVSLARNVALAAGARNPRVRPGLGGQWRNGQELDLQEEIDVEDAGLTDEPGALWYLVSQPIGYRQEEDRLRAEDPPSDLELVSDSSGGDAGGASKSWIRKIVVHTMSKDQGWSSSSQEHYGTYEQSYTWFELSLLRNGKDVEGSRIDFQHNVHAGQYFKEHVNTFEPDHKLLAMAKPGDRVVLWARAQFPGWVNHIRSASIAITESPFPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U849</accession>
    <name>A0A1Y1U849_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex I intermediate-associated protein 30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868487.1">
        <property type="nucleotide sequence ID" value="XM_022018657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U849"/>
    <dbReference type="STRING" id="4999.A0A1Y1U849"/>
    <dbReference type="GeneID" id="33560466"/>
    <dbReference type="InParanoid" id="A0A1Y1U849"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="1">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="253" mass="28581" checksum="981386B32037CA58" modified="2017-08-30" version="1">MTDHIFPPWRLDQWKAVDDRVRGGASTSHLDTVENLGRASSSRARFWGHLDIDTLGGAGFASQRFVFGPEPLHLPRHLFKGITIDIVDSGSSLRKSSVHTYTLVLKTSLSNRTQPPNVPPSPEPASLSYEASFTVGEPSSLGSKTRSIHLNINDFIATYRGRELPRSDPRYQPFHSEKIYELSLMCRSGFGEQKGDFELVIQGISRWRKESKSKAIVSFFSSIWNRATRWILSWFSTEGKVQLQDEEKQGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8D8</accession>
    <name>A0A1Y1U8D8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_638538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868075.1">
        <property type="nucleotide sequence ID" value="XM_022017126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8D8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8D8"/>
    <dbReference type="GeneID" id="33558935"/>
    <dbReference type="InParanoid" id="A0A1Y1U8D8"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="542" mass="58786" checksum="971B13337BC1CF9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8L3</accession>
    <name>A0A1Y1U8L3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867790.1">
        <property type="nucleotide sequence ID" value="XM_022018759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8L3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8L3"/>
    <dbReference type="GeneID" id="33560568"/>
    <dbReference type="InParanoid" id="A0A1Y1U8L3"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="816" mass="91719" checksum="81EF3213FA3F5A30" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U965</accession>
    <name>A0A1Y1U965_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_195844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868372.1">
        <property type="nucleotide sequence ID" value="XM_022012151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U965"/>
    <dbReference type="STRING" id="4999.A0A1Y1U965"/>
    <dbReference type="GeneID" id="33553959"/>
    <dbReference type="InParanoid" id="A0A1Y1U965"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="287" mass="31979" checksum="5C5897A1084882DE" modified="2017-08-30" version="1">MPVEDTFKRQKRRECHNQVEKRRREHINGKIEELGKLLPARYAEEAAQAEEDEEENRGSSKKKKKRPNPNTKQPRDAAQCKGRILSQSVKYIYELQHIQDMQNARIRQLESILASSGQIAPSAPPQYQHYIWNQPTHSTPIRRDSVAASPLAPAPTYFQPYPGMPRPMMHHIPKTTEDHHLEVMQPSPDPDATTRSNNSSWSGGNIHPASLTTSTSTSFSEGSGPHHIYSPEDAGLISGSSGSSPEQHLAHMVQKTGPTNQQPTEGLGLEVGLGPLDIEGHTVCWQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9E1</accession>
    <name>A0A1Y1U9E1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Muts domain V-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_583239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868892.1">
        <property type="nucleotide sequence ID" value="XM_022013609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9E1"/>
    <dbReference type="FunCoup" id="A0A1Y1U9E1">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9E1"/>
    <dbReference type="GeneID" id="33555417"/>
    <dbReference type="InParanoid" id="A0A1Y1U9E1"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="842"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117876" checksum="912A03D9D20292F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9G2</accession>
    <name>A0A1Y1U9G2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_634440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868912.1">
        <property type="nucleotide sequence ID" value="XM_022016729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9G2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9G2"/>
    <dbReference type="GeneID" id="33558538"/>
    <dbReference type="InParanoid" id="A0A1Y1U9G2"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="294" mass="33158" checksum="C2D9BC4E2510F862" modified="2017-08-30" version="1">MRIVFTGGSGRAGKHCVPYLLSKGHKVLNLDLVKLDHPDVMTLKTDLTDSGQVFNALTSLFSMDEYSLPERPGRPDAVIHFAAYPCNLIVPDNTTFTSNVAQTYNVIEAACKLGIPRIIIASSETVYNVCFTQGDSDYNQFPLDEETYDTNPEDSYACSKLCGERIARSFARRFNTDIYAFRIGNVIIPEDYKKFKQFAEDPASRKRNAWSYIDARDLGQICHLACEKGGLGYQVFNCTNDTATLNEKTGDFLKREFPNVKVTRELGDDEAPLSNKKIKDVLGFKEEHNWRKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9S8</accession>
    <name>A0A1Y1U9S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_584392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868134.1">
        <property type="nucleotide sequence ID" value="XM_022013682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9S8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9S8"/>
    <dbReference type="GeneID" id="33555490"/>
    <dbReference type="InParanoid" id="A0A1Y1U9S8"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="410" mass="45949" checksum="AA02569B8142D471" modified="2017-08-30" version="1">MEKVQFQLEATLPELQDLHDKGLFTKLEINQITKRRTALETSLVRQKTRKEDYFAYAEYEINLERLRKVRWKRLGYEENPPPPSASTYSIPRRVLYILKRATVKFPSDLAVWLAYVEFAAREGMRKVVLKGLTNALQHHPQSPTIYLLLSYHHIHPNEPFPRGVIPSSSSLTLPLAPEPSASFSIDGTSSARTTLLLGLRTCPKSHALWTEYIKLELGWVEVLRRRWSALGLEGGDKTKTAEISLDGGEGSFGPDGEDARKAILAGQLVTQALRSALETIEANADGMVFRENLLAVLRVYPSPLRQIGLDLLHEDLSRVEQAGGKEGARAKLLNLTRRLYEQPYGSTSAGDLALEGIELVEELGRIGKEIRKTAKGRDNAWTDIAGSWLHQQARDVRISAEMVSVCVCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA98</accession>
    <name>A0A1Y1UA98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_106837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869169.1">
        <property type="nucleotide sequence ID" value="XM_022011922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA98"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA98"/>
    <dbReference type="GeneID" id="33553730"/>
    <dbReference type="InParanoid" id="A0A1Y1UA98"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011809950" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="549" mass="60434" checksum="1BD3BC7DD5AEFB28" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAB2</accession>
    <name>A0A1Y1UAB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_636109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868747.1">
        <property type="nucleotide sequence ID" value="XM_022016869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAB2"/>
    <dbReference type="FunCoup" id="A0A1Y1UAB2">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAB2"/>
    <dbReference type="GeneID" id="33558678"/>
    <dbReference type="InParanoid" id="A0A1Y1UAB2"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26526" checksum="1CCBD926281D84C6" modified="2017-08-30" version="1">MASQITLHHLNASRSTRIFWVLEELGQPYDVRVHFRGPTRQAPQTLKDVTPFGKAPAVELDGELLVESGYIIDRILDLFPPGSDVESVPSNNSKFWSHYCEGSLVNYFQMSATLQITSAGWTSGAIGDLDEAGKAGVKKYANFLNETLIRGEITKNLGQMEKFLAEHPGKYLSGTDKPGSGDFQVFFPIYSLLEGTRKGVYEIGPATQAWWKMVMARPAAKRALERQNEEEERAKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAC1</accession>
    <name>A0A1Y1UAC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_638074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868313.1">
        <property type="nucleotide sequence ID" value="XM_022017080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAC1"/>
    <dbReference type="FunCoup" id="A0A1Y1UAC1">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="GeneID" id="33558889"/>
    <dbReference type="InParanoid" id="A0A1Y1UAC1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26810" checksum="B731938473C5F96F" modified="2017-08-30" version="1">MPTVLITGANRGIGAGFVEGYLAKGYTVIAAARDPSAVKTKDGVIPVKLDVSSQTDALDAVSELRSKHGLTSIDIIIANAGTHGTNQKLKDVPASVMHECWTVNTLGPLLLYQAVYPLIPRTGKFVVISSYRGMIGQQHETLEGAYGHSKAAVNYIVSKLHCEEVFITLALNPGWVQTEMGNRSAQFAGFGEKAPQQIQDVIGEAWREVKAQDKGWTLTSVPGQFLEPMINLIDKSTKNGNSGKFLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAF2</accession>
    <name>A0A1Y1UAF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_633572</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869215.1">
        <property type="nucleotide sequence ID" value="XM_022016634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAF2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAF2"/>
    <dbReference type="GeneID" id="33558443"/>
    <dbReference type="InParanoid" id="A0A1Y1UAF2"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="240"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="344" mass="37669" checksum="7536F756127B4CA7" modified="2017-08-30" version="1">MTVSPISATELDRVLQRAKRKDDLGHKIANALDLIDQQLQSLGEEAVAISFNGGKDCTVLLHLYAAALYSRHERVSAPDAWPRPTDDQTAEHSDAGQERSNGRLSQEIRAISHSSPRTGSGSDVSTGNVPIDGPSRPPPPLPPQCTTSSDQVESSTSATRHGRLDQSTASSYSAPSSSSKLPYPPIRSIYITAPDPFPELETFVLDSAERYGMDLYRFGGGMKAALEEYLNCGGGRGVKGVLVGTRRGDPNGDVSELAPTDPSWPQFLRIHPILFWSYGDIWTFLRELDVHWCSLYDQGYTSLGSTKNTVANPELKRGADQWEPAWKLQDESKERAGRFRPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAH0</accession>
    <name>A0A1Y1UAH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869235.1">
        <property type="nucleotide sequence ID" value="XM_022018545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAH0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAH0"/>
    <dbReference type="GeneID" id="33560354"/>
    <dbReference type="InParanoid" id="A0A1Y1UAH0"/>
    <dbReference type="OrthoDB" id="3353673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="446" mass="49247" checksum="E1DFC65D38C40FB4" modified="2017-08-30" version="1">MPTPKWYPQTQNPQSFHYRTSGRPRDANKPVDPKTLLPLPSMDQHTYYDSPASPSSSSTSSSASDLPFADNVPSNSGKKKIISSRFARRGKMYAWAPSYEAVKVDYRVRKRMKACMECFLPEAAAEVGVAPPANILRAETRREKRKRKREEDSEWVLPHLKSPSPPLSTGKLAPMLALPQSYVDIMLSPAMRHSLEDDTVENGLQGTTQELLEGEKGLMQACGRLREILRLRDRDVQVAKVAESNSNHEQPNGHSEVEVDSDETSNNAIAGPSSSSRAASVAAPDRNEQIPPLPHVTDVDNLWRVTQELLMAVPAPTIKYAATKPGTAAPVNGVPEPIVTATPVQRLFTCPDGITIMAEPAANAPGMAFSASHPGRPRTIKYNLDMAAQCRAVDDALERVAELLADCMEYKERLEEARDRVADVARARKRIWGVVKERAGFEMDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAK3</accession>
    <name>A0A1Y1UAK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_583405</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868789.1">
        <property type="nucleotide sequence ID" value="XM_022013623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAK3"/>
    <dbReference type="FunCoup" id="A0A1Y1UAK3">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAK3"/>
    <dbReference type="GeneID" id="33555431"/>
    <dbReference type="InParanoid" id="A0A1Y1UAK3"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="558" mass="61750" checksum="FA6C15F2E2DB6591" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB10</accession>
    <name>A0A1Y1UB10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_82122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869410.1">
        <property type="nucleotide sequence ID" value="XM_022019257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB10"/>
    <dbReference type="GeneID" id="33561066"/>
    <dbReference type="InParanoid" id="A0A1Y1UB10"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="959" mass="103563" checksum="C5A54F447AA716C5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB20</accession>
    <name>A0A1Y1UB20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_565391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869423.1">
        <property type="nucleotide sequence ID" value="XM_022013036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB20"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB20"/>
    <dbReference type="GeneID" id="33554844"/>
    <dbReference type="InParanoid" id="A0A1Y1UB20"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="139" mass="14731" checksum="4C431F54E166B75A" modified="2017-08-30" version="1" fragment="single">SSLPPEAIELASRIFNYARTGSPLLAQYLSAGIPPNMTNSAGDTLLMLAAYHGQIESVRCVLTHGADINLVNGRGQTPLAGAVFKDYHGVVTILVEAGADSKAGRPNAMETAGMFGRRECARIMGLDWDECVRSVPEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB32</accession>
    <name>A0A1Y1UB32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_631976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869433.1">
        <property type="nucleotide sequence ID" value="XM_022016482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB32"/>
    <dbReference type="FunCoup" id="A0A1Y1UB32">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB32"/>
    <dbReference type="GeneID" id="33558291"/>
    <dbReference type="InParanoid" id="A0A1Y1UB32"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="174"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="551"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="600"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="642"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="684"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="726"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="849" mass="91719" checksum="FE8A229CE827C5CF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBB9</accession>
    <name>A0A1Y1UBB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_661386</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
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        <property type="protein sequence ID" value="ORX35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869499.1">
        <property type="nucleotide sequence ID" value="XM_022018898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBB9"/>
    <dbReference type="FunCoup" id="A0A1Y1UBB9">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBB9"/>
    <dbReference type="GeneID" id="33560707"/>
    <dbReference type="InParanoid" id="A0A1Y1UBB9"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="194"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="456"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="746" mass="82862" checksum="064D976676CD626B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBC4</accession>
    <name>A0A1Y1UBC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_632498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869538.1">
        <property type="nucleotide sequence ID" value="XM_022016523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBC4"/>
    <dbReference type="FunCoup" id="A0A1Y1UBC4">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBC4"/>
    <dbReference type="GeneID" id="33558332"/>
    <dbReference type="InParanoid" id="A0A1Y1UBC4"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="327"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="416" mass="46297" checksum="11A9DF25FAE2E0C4" modified="2017-08-30" version="1">MTDFEHHGIMAEPSSTDAGPSASSSQNASTSTDQAEKTPVVILCIGMAGSGKTTLMQRLNSHLHSRNTPPYILNLDPAVSHMPYSANIDIRDTVDYKEVMKQYNLGPNGGILTALNLFTTKFDQVLAFVEKRAASVDYVLVDTPGQIEIFTWSASGSIITDAIASSLPTVVAYIIDTPRTTAPATFMSNMLYACSILYKTRLPFILVFNKIDVEPHDFAIEWMHDFQAYQAALDEKGRDEQGEMAYTSSLMSSMSLVLDEFYNNLRAVGVSAMTGEGMKDFFSAVEEAKKEYETDYKPELARLAEERKAKAEEEKKNQLEKVMRDMTMSEGAASRRKNPFGPHPRNEREDRYLDDEGDDIDSEEEREIQRQMEEEEEMEHAEDLDAGDMAEPEPGAGGVAGVQSQSRTGMSWPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBU6</accession>
    <name>A0A1Y1UBU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_682816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869679.1">
        <property type="nucleotide sequence ID" value="XM_022019164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBU6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBU6"/>
    <dbReference type="GeneID" id="33560973"/>
    <dbReference type="InParanoid" id="A0A1Y1UBU6"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="185" mass="19503" checksum="6E5B3F9B9B48D8C7" modified="2017-08-30" version="1">MPSSKGKPTDPKLRENLKDKIKNEGNKDGSGKGQWSAWKAAKLGKEYEAKGGDYENEAGSKNEPKKGTPEPKTESKKAKETKSTKSKDEPKEEAKETKSTKAKETKAKSTSTKETKSTAKSGSKATTDSKSKSSASATKKAAPKATKSAGKRTSGATEKKTAAAEKSKDAAAKKSSAKSKKTASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBY9</accession>
    <name>A0A1Y1UBY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-aminoacylase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_581698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869714.1">
        <property type="nucleotide sequence ID" value="XM_022013520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBY9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBY9"/>
    <dbReference type="GeneID" id="33555328"/>
    <dbReference type="InParanoid" id="A0A1Y1UBY9"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01297">
        <property type="entry name" value="D-aminoacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="entry name" value="D-aminoacylase. Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="56"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="599" mass="64387" checksum="CBFB6C10B27BA8D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC55</accession>
    <name>A0A1Y1UC55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic-AMP phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_64009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869785.1">
        <property type="nucleotide sequence ID" value="XM_022017316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC55"/>
    <dbReference type="FunCoup" id="A0A1Y1UC55">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC55"/>
    <dbReference type="GeneID" id="33559125"/>
    <dbReference type="InParanoid" id="A0A1Y1UC55"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="498" mass="53614" checksum="8500A629A567272E" modified="2017-08-30" version="1">MRTKPALAGSGRKRASNAADRLSTSSAPLSPIGQPATRRSSRSSVDKGKQKAAQAPPHETAGRHVQDAFEIVVLGAGGGPLETDVSGYMLKPAHKGWEEGFVALEGGSGLGALTELIDRHGSSSLFPSTHFPPTHHTALLKAAYIFSYLSCYLITHAHLDHVQSLILFSGSMPPRGQPPDASILSPPLTSKAHSSDDDASSDKDDATPAPSRMPVRVLGAKPTLDRLSLAYGGELWPEIADWEKSHGGSASRLEARRGSLGSYSDGPLHPESHGSEMILVPLPGNDEPVKVSPSLPLSVRQFEVSHGSTSKGAYESTALFIRLTDHTVDDAMTHLGHGFDARSDSSKEPELLFFGDVESSYRSPGSEDQDTAARDRAEQCNGVIWAEAADLWAQGRLSGIFIECSYDNDRSADLMFGHMHPYGLMHELSILAAKVTPSRDRPLAGLKIYITHIKAYLLPHPSGQTASERIMSQLDALEKERNLGVDFVEVKRGMRIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC87</accession>
    <name>A0A1Y1UC87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonucleases P/MRP protein subunit POP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_603000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869815.1">
        <property type="nucleotide sequence ID" value="XM_022013955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC87"/>
    <dbReference type="FunCoup" id="A0A1Y1UC87">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC87"/>
    <dbReference type="GeneID" id="33555763"/>
    <dbReference type="InParanoid" id="A0A1Y1UC87"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="5">
        <location>
            <begin position="423"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="6">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="640" mass="72575" checksum="A93BEB164F8C7B9F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC99</accession>
    <name>A0A1Y1UC99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_634571</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868947.1">
        <property type="nucleotide sequence ID" value="XM_022016743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC99"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC99"/>
    <dbReference type="GeneID" id="33558552"/>
    <dbReference type="InParanoid" id="A0A1Y1UC99"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15585">
        <property type="entry name" value="PHD_ING3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000535">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042020">
        <property type="entry name" value="ING3_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="457" mass="49122" checksum="C6400BE84BC451C3" modified="2017-08-30" version="1">MPPRVIPPQASMSPAPMENIAPNDAQDILVIQDVMDTLDQIPPELTRVHSDLNELGAVLYSTLVGLEKNLNKLIDWVQDPTITPDKRFALLQDIAEEAARYKLGGDDKIRVAGGACDGIMAHQRHISNLIASSTLFQRGPLSPYSYNLTLSQLPPHANTRRGQLARAVNSPFVVAPRAATVGASGLPEGAVRDTPSKKKKHRVQALGRDDDDASSVGGEKKRAPAKKRRQRAVSPADSLASTSAFNGKPSQPQTARQLAAAANKARKAERADESDDESGDEGRQDALGLDIGSREGSQAGGKSINATPVLANGTVLPAGDRRGSRAGRAGQKRSRADDEDGEEESDGDDVKPKRTNGSAPSAFMSRKSSGMDDSDALDGDGQGVDGDADTKLYCTCRQISYGEMIACDDEECEVEWYHIHCLGFDKPPEGNWICPQCVERRKKNPGKKRAGKAKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCL4</accession>
    <name>A0A1Y1UCL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_609533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869457.1">
        <property type="nucleotide sequence ID" value="XM_022014156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCL4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCL4"/>
    <dbReference type="GeneID" id="33555964"/>
    <dbReference type="InParanoid" id="A0A1Y1UCL4"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="714" mass="75273" checksum="E75DD471CCD6FB8D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD10</accession>
    <name>A0A1Y1UD10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869604.1">
        <property type="nucleotide sequence ID" value="XM_022016551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD10"/>
    <dbReference type="GeneID" id="33558360"/>
    <dbReference type="InParanoid" id="A0A1Y1UD10"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="541" mass="60747" checksum="45EC9750372EBBB0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD42</accession>
    <name>A0A1Y1UD42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_652708</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869201.1">
        <property type="nucleotide sequence ID" value="XM_022018538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD42"/>
    <dbReference type="FunCoup" id="A0A1Y1UD42">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD42"/>
    <dbReference type="GeneID" id="33560347"/>
    <dbReference type="InParanoid" id="A0A1Y1UD42"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="30"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="112" mass="11891" checksum="3F51DC546BD3F451" modified="2017-08-30" version="1">MSGRGGGRGGGPSRGGAPSGGHAGDKKKRESILNLQTYVDQSIRVKFMGGREVTGILKGYDQLMNLVMDEVVEEYENGSMPSRELGLVVLRGPNVVLISPTDGSAEIENPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD69</accession>
    <name>A0A1Y1UD69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869664.1">
        <property type="nucleotide sequence ID" value="XM_022016583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD69"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD69"/>
    <dbReference type="GeneID" id="33558392"/>
    <dbReference type="InParanoid" id="A0A1Y1UD69"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="68"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="243"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="450" mass="48778" checksum="DAC4096F92F24E52" modified="2017-08-30" version="1">MRAVESVSIAPKNRQTIHTSLLFDSKSKSWSRDISLVVSLKTGNIVSTFHRDGQTEIALDDIDLRGLTVIPGLVDAHTHIFLHSYDETPSINQERDESEVERILRASNHLKAALKAGYTTYRDLGTEGMRDLDTGVRNAVNRGIIPGPRLFVATEALASPGGYEVRIESKDQGTTTGRISDPCSGVDGVQAAVRRRLGAGADLIKFYSAYRQRSLRFPPAAWPGALPIQHPPGQVEDDEDEGGDALFANEADPPTPLFTLEEMKAIVATAKRSKCPVAAHTTGPEMVIEAAKAGVTTVEHGYRRSKESIKALKENGTIYVPTLAVAEELSPKLLNEALEQVYDAWNSGVRMACGGDTGAFNHGENLKELLLFERAGIPLEAVLEAATMGGWEACGGDWCGRRFGSLEKGWAADLVAIKGDPRNGGIKCLWNPEWVIKDGKVVVEEAKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDK6</accession>
    <name>A0A1Y1UDK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_630234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870242.1">
        <property type="nucleotide sequence ID" value="XM_022016309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDK6"/>
    <dbReference type="FunCoup" id="A0A1Y1UDK6">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDK6"/>
    <dbReference type="GeneID" id="33558118"/>
    <dbReference type="InParanoid" id="A0A1Y1UDK6"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="476" mass="53878" checksum="D37F04D548795F96" modified="2017-08-30" version="1">MVQLYECPYPRVSPQDKHSFAYVTLIKRWPTILPGVINTVSNVNHELHSQSSPEAQDKLTEGKAIISKISALKHDMGRNGQLVDIENDGQGNVDCYNRELATFTGDQRGWSHVNWLFAECYLYRRLRNFFALTKHWRDFDPFFPSKAETYKSSSAAIIHLAKALNTLVRRTDLSQDFEREGSALEIAFLEMVQADLWGNATDLSLLVDLKYEDLQKLQAVGAAAQAEQAKYILRNDLPKVWEYLKTVKDGRLDIVMDNAGFELYTDFILADFLISCTPFVKEVVFHGKAIPWFVSDVLPYDFTWAIDSLLDVSFFASASKPPKEGESEELKTLATRWKSHLSSGKFKLSVPLDTPLGDAQNEEIGGFWTTQYSYQDLPKVAPKLLEELQKSDLVLFKGDLNYRKLVGDAWWPTTTPFEEALGPLKGKITLLSLRTNKADTIAGLPEGVAERLNKEAPDWRTSGKYAVVSFCEKHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE18</accession>
    <name>A0A1Y1UE18_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA-processing protein TSR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_652459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869515.1">
        <property type="nucleotide sequence ID" value="XM_022018496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE18"/>
    <dbReference type="FunCoup" id="A0A1Y1UE18">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE18"/>
    <dbReference type="GeneID" id="33560305"/>
    <dbReference type="InParanoid" id="A0A1Y1UE18"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="25157" checksum="949705C6935AAECD" modified="2017-08-30" version="1">MASSSSSSNPAQAAPSLPSPTILLFARGVVALLDLWPALTIAVAEQWGGAESAEKKVWMASVIVDEFESRAVFLPSTAGAGSDTATPAAPVVDPRTADDPPLDLDDLGDLIHQMMSDEFDANIEDNSIDAVTADILRLWKDLLSPSTNTSPENLVSALETRAGQVKRSGVNASSGGGPQEMNGGDVHDDEAGDWTDSDNSEDDGEVPQLVPVKQEKEKVEPVFDEDGFELVQKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE21</accession>
    <name>A0A1Y1UE21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_628195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870392.1">
        <property type="nucleotide sequence ID" value="XM_022016096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE21"/>
    <dbReference type="FunCoup" id="A0A1Y1UE21">
        <property type="interactions" value="651"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE21"/>
    <dbReference type="GeneID" id="33557905"/>
    <dbReference type="InParanoid" id="A0A1Y1UE21"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="54"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="10">
        <location>
            <begin position="282"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="11">
        <location>
            <begin position="514"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="633"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="761" mass="84171" checksum="8571933E497328FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC3</accession>
    <name>A0A1Y1UEC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_609032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870473.1">
        <property type="nucleotide sequence ID" value="XM_022014140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEC3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEC3"/>
    <dbReference type="GeneID" id="33555948"/>
    <dbReference type="InParanoid" id="A0A1Y1UEC3"/>
    <dbReference type="OrthoDB" id="2565217at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="358" mass="38900" checksum="C03F650E45530778" modified="2017-08-30" version="1">MDRQPSAFSARQQTADPNRVPQMRRDSPKSGTDGVMDAATPTKESKRDRSLTDAQKVQLKALQAAGRVESGKTADPPKVASPSADRVVKAEEKSLSQSERARKVKEQRLSSTSSSTDKGKARMTEQEADDGLSTDDTGAESTSTAASDDKMEDPLMAGDYRPLKSVLKKSKKKPRQKKNIHHNYYMTMRGHKPSLIPFPHGFHPKPHHPRNTLWFDNVPDNADHIMAPPPVPKLPEEGKEEEQEDEGEKKARSGTGDEKDGKTSGSEDKEGGAKTETSTEIKASQSRSTSGSRSTSGPEKPAAATKDSGSDDKTSEERANARATADREAKARARANAESDRNQGSTVNPDKTPINTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEH0</accession>
    <name>A0A1Y1UEH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_629561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870056.1">
        <property type="nucleotide sequence ID" value="XM_022016225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEH0"/>
    <dbReference type="FunCoup" id="A0A1Y1UEH0">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEH0"/>
    <dbReference type="GeneID" id="33558034"/>
    <dbReference type="InParanoid" id="A0A1Y1UEH0"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24763" checksum="E373F61A36EB30E6" modified="2017-08-30" version="1">MADAAQLEKHLSTRAYIDGYEPTSADVEAYNGLKSAPDAKEYPHTARWYRHIDSWKSEHSSLPKGTALAASSSSTSAPAAKKDEEEAEAEDDDEIDLFGEDEEEDAEAERVKAERVAKYNEAKAAKAAANAAAGKDAPVAKSVVTLQVKPWDDETDMDAMEKDVRAIEKDGLVWGASKLVPVGYGIKMLQITLVVEDAKISLEELQEEIAELEDYVQSTDVAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEX7</accession>
    <name>A0A1Y1UEX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_626363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870641.1">
        <property type="nucleotide sequence ID" value="XM_022015887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEX7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEX7"/>
    <dbReference type="GeneID" id="33557696"/>
    <dbReference type="InParanoid" id="A0A1Y1UEX7"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
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        <property type="entry name" value="Zswim2"/>
    </dbReference>
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        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="381"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="536" mass="58832" checksum="25E94FF7A2380C60" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF16</accession>
    <name>A0A1Y1UF16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromatin remodelling complex Rsc7/Swp82 subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870648.1">
        <property type="nucleotide sequence ID" value="XM_022018259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF16"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF16"/>
    <dbReference type="GeneID" id="33560068"/>
    <dbReference type="InParanoid" id="A0A1Y1UF16"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="821" mass="89916" checksum="BB3E16189083D457" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF64</accession>
    <name>A0A1Y1UF64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_581734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869879.1">
        <property type="nucleotide sequence ID" value="XM_022013521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF64"/>
    <dbReference type="FunCoup" id="A0A1Y1UF64">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF64"/>
    <dbReference type="GeneID" id="33555329"/>
    <dbReference type="InParanoid" id="A0A1Y1UF64"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="183"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="358"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="441"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="796" mass="85294" checksum="B819185A735A9FCE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF83</accession>
    <name>A0A1Y1UF83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_528265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870295.1">
        <property type="nucleotide sequence ID" value="XM_022013002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF83"/>
    <dbReference type="GeneID" id="33554810"/>
    <dbReference type="InParanoid" id="A0A1Y1UF83"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="239" mass="25854" checksum="29C1F55ADF804C3C" modified="2017-08-30" version="1">MLYHLPDGDLTLTGLPVALGSSRSPTFDQPTTVTVKRKRSIGRCIVDQDDIIEEFPVTKRQITQRSRAGDNNDGALTIVTTRHMAEGYSPRLANCGLHTPPPESPTCIPLDSDVQHDGYHRVLTRVDTIDSINNPTITIGCRSASQDTELSSEPDGCRMDGNCDGCPYQHGTDMISTIDSLCLDRDHDGVASCVIFNASSPRIAYQSPTCASVTDESEYIPTPGDDAVTLELFGGLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFD7</accession>
    <name>A0A1Y1UFD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_626864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870768.1">
        <property type="nucleotide sequence ID" value="XM_022015938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFD7"/>
    <dbReference type="GeneID" id="33557747"/>
    <dbReference type="InParanoid" id="A0A1Y1UFD7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="444" mass="47868" checksum="1DE3C713D91834C4" modified="2017-08-30" version="1">MSTITSPQGYTAVSGGYVTLDPTSPLLIFDPPLVPWSYNASLGLPPPSSAWNTSAPASSWKEWENTGLLSGSEIWAFTDTPGSSFTFSFVGSSAYFFGSFANQNTAQQNETLSVTVDNEVMTASNSNSDKASPSALTVSGFGLGQTPEDGYLGYIGQLSNDYHEITLKLNKDWLNLSSIGLNYLSGSSHATPLEEGFSVPYTLPNVTSASGYEVAANGTWLTGTPPSSYQSTWTPGSSLLYNMPPNASFVTFSGYAGPDAGNYSVTLQEVGVTAGEPGTISWYGMATVGMPATTTYTAKRQWREYGSVLYATSLDTLQQYEMIITFLGPDGSRFAVGDFNYNVDQLMIPGSTSGTVLSTNDLIGVIVGVVGFIAIACFVLFCYRQRRRRRLPTIRGPDFYSKNDIPMDRASYWEAAKADVEVNERDEVVLPEVTVARPPPIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG28</accession>
    <name>A0A1Y1UG28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_628968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870567.1">
        <property type="nucleotide sequence ID" value="XM_022016157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG28"/>
    <dbReference type="GeneID" id="33557966"/>
    <dbReference type="InParanoid" id="A0A1Y1UG28"/>
    <dbReference type="OrthoDB" id="2224399at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="222" mass="23614" checksum="FBF0B6A1C1C29D76" modified="2017-08-30" version="1">MGIDAAAVGPFLGKPSRDDLVVALGGQSSSSSSADIKSYPDAVYHNHYSHGFSCCFNPTSTNSPDAVLSQVDIFNPPSGSVSRKKASWTGYTTPSLPIVLRFPTTSLSVPTPDGKPSTITRPDILEVEKQTTGKDFVACLGEPSRKGGGQGFVSPWLEWGDVELKSGESSIAKVGIMVELRDPGAHEVLSDEQKTKGAGGVWDRASGWTWGSLKLFDPNDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGA4</accession>
    <name>A0A1Y1UGA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_624462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871047.1">
        <property type="nucleotide sequence ID" value="XM_022015706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGA4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGA4"/>
    <dbReference type="GeneID" id="33557515"/>
    <dbReference type="InParanoid" id="A0A1Y1UGA4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="308" mass="33497" checksum="FA9BE743F7754652" modified="2017-08-30" version="1">MVRSIILPDGKRMPALGWGNGTRGVEHSGKFAVDVGAAALREGILHIDTAQAYGTERETGEAIRLAEVPREQVWVTTKIYEGSGQPHRKVGEVRAAVQESVAKLGFIPDLLLVHTPFVPEDGRLLAFWQELENMVEDGTLQGCSLGVSNFRPQDIEILMHSARIKPVCNQIEFHPYALAHLDSLFATHSKYGIATQAYGPLQPLIAHPTGGPIKPILKRIAGILSNDSGQNVDEASVLLLWTIGKGAAAITTSSNPVNIAKMAAIDRLRDLTEAEIDEIDQAGRKVHFKGWAGHMSKDYPVPDLPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGB7</accession>
    <name>A0A1Y1UGB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_579435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871148.1">
        <property type="nucleotide sequence ID" value="XM_022013378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGB7"/>
    <dbReference type="FunCoup" id="A0A1Y1UGB7">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGB7"/>
    <dbReference type="GeneID" id="33555186"/>
    <dbReference type="InParanoid" id="A0A1Y1UGB7"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="48138" checksum="B06AC824903B5C06" modified="2017-08-30" version="1">MPSLRSWRLPASSLSSSTRLSTSRTLPRLRPLANLHVRGYKASSGRQPQPPRDIMTGEIVALPDIDPSLVKIQDNPKRKTPPPSSKLVFGRTFTDHMLTIPWSSASGWGTPEIKPYGPLVLDPSCTVFHYAFTTFEGMKAYRNEDGTVRLFRPDKNMARLNRSASRIALPAFDGEALSQLIQKLVLMDSEWIPKEKGYSLYIRPTMIGTQNALGVGPSSDALLFVICSPVGPYYASGFKPVQLLASTKYVRAAPGGTGSYKIGANYAPGVVPQSEAAKEGYSQNLWLYGDEHEITEVGTMNLFVSFKKPDGTVELATPPLDDIVLPGVTRLSVLELAREHVKGNKIPGLPEKLEVNERRMVMAEIVEAQKNGTLLEIFGTGTAAIVSAVDRIGFQGKDIPIPVGPDGMGPIAKAVLDRVVGIQTGEFEHEWSVIAKDTVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGC4</accession>
    <name>A0A1Y1UGC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871116.1">
        <property type="nucleotide sequence ID" value="XM_022018191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGC4"/>
    <dbReference type="GeneID" id="33560000"/>
    <dbReference type="InParanoid" id="A0A1Y1UGC4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="273" mass="29570" checksum="896CD6E98B3DA90C" modified="2017-08-30" version="1">MSTLSSLSPPYSWTTAIDSGIASSNMASSNMVSSGDILSADLMTWCPHTAASGSPLTGLIPDWDNTLSSSSSTIRRIPSESGDTFNDPMTLLGANEQQISMAGSAASLLYEAFRLETEHDTLKEEYTSKLALSSTETEHDNLRKEYDSKLALNSEAQTENASSLVKAWRTQRASTMKNTLPVVFKGARNESDILGIFSDVASVDEDSVDGLLDWFAEQDTETADAVGPEFRKMVDKASNITPSLSIQTPAKQISDGNQQISRHRRSDKLAVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGF9</accession>
    <name>A0A1Y1UGF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_642792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870284.1">
        <property type="nucleotide sequence ID" value="XM_022017505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGF9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGF9"/>
    <dbReference type="GeneID" id="33559314"/>
    <dbReference type="InParanoid" id="A0A1Y1UGF9"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF12">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011011362" evidence="4">
        <location>
            <begin position="19"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="512" mass="57772" checksum="2276FC2610A39D17" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGH0</accession>
    <name>A0A1Y1UGH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_624871</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871156.1">
        <property type="nucleotide sequence ID" value="XM_022015744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGH0"/>
    <dbReference type="FunCoup" id="A0A1Y1UGH0">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGH0"/>
    <dbReference type="GeneID" id="33557553"/>
    <dbReference type="InParanoid" id="A0A1Y1UGH0"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000009">
        <property type="entry name" value="Phosphoglucomutase, cytoplasmic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="205"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="307"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX37118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="584" mass="63256" checksum="2234BBDFBC239B27" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGK8</accession>
    <name>A0A1Y1UGK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_625154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871238.1">
        <property type="nucleotide sequence ID" value="XM_022015774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGK8"/>
    <dbReference type="GeneID" id="33557583"/>
    <dbReference type="InParanoid" id="A0A1Y1UGK8"/>
    <dbReference type="OrthoDB" id="2572490at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="487" mass="55007" checksum="C7750E0100F438FF" modified="2017-08-30" version="1">MSGLRVEAPHICIPPFPISPPDVKAPAFSAYRVKGIRTRTLRRGDCTTQICSDYNEQFLIQIEGHAPKESVNQPIPSSKAWDIGDLGGTWAEPPAVGEVEYPQLVPPFRRLVWATEEFQRSRREALSFGRTKRLFEQLRITLGLKTSFPGLHRSGHGEGALPYTYPASVRKTQSNHDETGQMESCVLLAKTESSVRGLLALARRIVEAEWDLAPAIELARMTAAFLAFLLHFKVLEETDYSAPISRALMIAQAAPEELKASKRLEDIVGDPLGWNLLCWMAWGDHYASSERARGESAKGREREIQSSDGGWGLSELSPQDQFTVQPDQARHLLETRFTKLIFHEVKVLSYIPFSRRKVKAIVAPSSPGESDNFRDTHWRVTTVAAPWTDDESWSHQTAHVSEVNQAQLPNQIDFEAEKQRGEEPTEIDIWIDGTDFEYDWTSVIGSGLRGRWALIGDSEQSAWWVFKARDYILPRFWQPINAGPRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGV7</accession>
    <name>A0A1Y1UGV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative Dynamin protein dnm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_608989</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870406.1">
        <property type="nucleotide sequence ID" value="XM_022014136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGV7"/>
    <dbReference type="FunCoup" id="A0A1Y1UGV7">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGV7"/>
    <dbReference type="GeneID" id="33555944"/>
    <dbReference type="InParanoid" id="A0A1Y1UGV7"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="770"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="861" mass="94311" checksum="87F37AA56B883781" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH85</accession>
    <name>A0A1Y1UH85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_579948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870913.1">
        <property type="nucleotide sequence ID" value="XM_022013418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH85"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH85"/>
    <dbReference type="GeneID" id="33555226"/>
    <dbReference type="InParanoid" id="A0A1Y1UH85"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42560" checksum="067DC39B2DAA4356" modified="2017-08-30" version="1">MLKGGLPRFYVPLLEKSQPRDLQSTPLSCRSITSRALSATLLLALGVILGSTFSVFSSYQPPPLAVALPPIPTNTDLPVPSLPLPREPIPNIVHYVYGLDPDSTREDFPYYAYLAMRSALVTLKPEKVLFHCLYEPRGYWWSRVVNWEGWVDDEGQRKGLVEIHRARDVTTIGSHKNPVTKFAHKADIIRLEVLLQHGGIYLDIDTFILRSFSKHSLLAYDTVMAMEAAQWDLGDSMDPKGLCNGIIVARKGATFLERWLETYETFNGHKWADHSVHMPWVLAKLYPETITVLSNRAFFWPLWISSHISLVYKSTDYDFEASGQLAYHAWESKAKSHLRALNPSTIQSITTSFTIMARKYREHNEERNWKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI77</accession>
    <name>A0A1Y1UI77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_641868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871747.1">
        <property type="nucleotide sequence ID" value="XM_022017453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI77"/>
    <dbReference type="FunCoup" id="A0A1Y1UI77">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI77"/>
    <dbReference type="GeneID" id="33559262"/>
    <dbReference type="InParanoid" id="A0A1Y1UI77"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="119"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="435" mass="48476" checksum="296F89AC7E6E8459" modified="2017-08-30" version="1">MPLSQLNDWLTKNDSSTAEVAQEPANGDGAPNSSVEQDSYLQEDHSEEDEEEDGVPNECKKKKSTQSEPPRVGLTKLFKDRIYPVGQEVDYVGTSRMSSAEARERERLAQEDPSTNYQNIRRAAEVHRQVRSYARKNIKPGMSMTDIANMIEDGTRALVEENGLESGIGFPTGLSVNEVAAHYTPNAGDTKVLRDTDVIKVDFGVHVNGRIVDSAFTLNFEPTWDRLLEAVQDATNAGIKTAGIDVRMCDIGEVVQEVMESYEVEVRGKTHQVKSIANLSGHSIAPYCIHGGKSVPIVKQFGSDQDNEKMEEGEYYAIETFGSTGRGRVIEEGACSHYALSREQPERYTLHHQSARSLLKSIERNFGTLPFCRRYLDHVGEKNYLLALNTLVKENLVTDYPPLVDPQPGAMTAQYEHTILLRPTCKEVVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI93</accession>
    <name>A0A1Y1UI93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871295.1">
        <property type="nucleotide sequence ID" value="XM_022015799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI93"/>
    <dbReference type="FunCoup" id="A0A1Y1UI93">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI93"/>
    <dbReference type="GeneID" id="33557608"/>
    <dbReference type="InParanoid" id="A0A1Y1UI93"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="75"/>
            <end position="384"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX37257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="45766" checksum="FCDB1AE61F4118A7" modified="2017-08-30" version="1">MRSHVTRRLISQWRGSEGGRRASHDFIRGPTPGGTFKVPFPSPKIVGIQAARGTSAEQQDQSAVHALQLSPAEIQYSLEKIKYKWDASKAGSPFLASQVAFFGIYDGHGGAQVSTHLAENLHNLIESVQSDHANSLVQWTKSTHQGYFKRWRGGVLSKWTKAGQTSDASAQTSTSGPSGKVMTLEERLTLAFLQADQDILKKYEESHKMGSTASVLLLHSLDSPAVPYWAAKEVFLTVGHCGDTRVLLCHAPTGKVVPLTERHHAEARVEAARLRRMGADNLIQDSFGESKWMGAIENTRGFGDGDWKSSGVTAEPEVISRVLKGAEYSYLVLVTDGLTDLMSDQEIIDLARNASDPTRAATTIIHFGEDLNADDNCTCIVVPLAGWGQVKGQDSTEARREYRRNQAGMMNTRMQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIQ4</accession>
    <name>A0A1Y1UIQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871414.1">
        <property type="nucleotide sequence ID" value="XM_022018241.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="33560050"/>
    <dbReference type="InParanoid" id="A0A1Y1UIQ4"/>
    <dbReference type="OrthoDB" id="3366922at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="152"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
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        <location>
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            <end position="928"/>
        </location>
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            <begin position="1005"/>
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        </location>
    </feature>
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            <end position="1056"/>
        </location>
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            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
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            <begin position="293"/>
            <end position="303"/>
        </location>
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            <end position="420"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="490"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="916"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116138" checksum="9B564CB7F47E8271" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIQ5</accession>
    <name>A0A1Y1UIQ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871930.1">
        <property type="nucleotide sequence ID" value="XM_022018152.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIQ5"/>
    <dbReference type="GeneID" id="33559961"/>
    <dbReference type="InParanoid" id="A0A1Y1UIQ5"/>
    <dbReference type="OrthoDB" id="2526154at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="709"/>
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        </location>
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        </location>
    </feature>
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            <begin position="1068"/>
            <end position="1095"/>
        </location>
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            <begin position="1121"/>
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        </location>
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        <location>
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            <end position="1302"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="42"/>
            <end position="52"/>
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    </feature>
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        <location>
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            <end position="965"/>
        </location>
    </feature>
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        <location>
            <begin position="991"/>
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        </location>
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            <begin position="1069"/>
            <end position="1092"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1172"/>
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        <location>
            <begin position="1237"/>
            <end position="1248"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1302" mass="137087" checksum="20EF2A5EEF2C8543" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIT8</accession>
    <name>A0A1Y1UIT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_448806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Kockovaella</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIT8"/>
    <dbReference type="GeneID" id="33554618"/>
    <dbReference type="InParanoid" id="A0A1Y1UIT8"/>
    <dbReference type="OrthoDB" id="2565285at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="240"/>
        </location>
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            <end position="130"/>
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        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX37414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="297" mass="32213" checksum="74BDA7F87529FB56" modified="2017-08-30" version="1">MFNKHPSQFLGKTDPKDPAQVKVAVENMKKWARGKLKKGTLREVAGRGGKLEQLEIEFAHRGYQDIFYLTRFELSLPPSRLNLPQPSSPVAKTLADANFPLRNLAQSTPSGHSRKQDDARRQNSPEDAKHVAPPVAAAPTMTPAREDKGKRMTVGVKEITWGKQDSKTAPKVPTQASGPSTPPSPILYVPPRPPHPEAAAKLDSPIKMVTPSKDYPSVPPGAGVASTRPPGAGIASTGIKPGQIAPVSILQTSSTMPPPRVSMLDPSSATKTIVDRARHSWQLARPLRSRKKRSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIW0</accession>
    <name>A0A1Y1UIW0_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_651027</name>
    </gene>
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        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871472.1">
        <property type="nucleotide sequence ID" value="XM_022018251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIW0"/>
    <dbReference type="GeneID" id="33560060"/>
    <dbReference type="InParanoid" id="A0A1Y1UIW0"/>
    <dbReference type="OrthoDB" id="2574480at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="757"/>
        </location>
    </feature>
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            <end position="261"/>
        </location>
    </feature>
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            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
            <begin position="708"/>
            <end position="735"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ORX37434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="757" mass="80335" checksum="2AB12B50871D41FB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIW6</accession>
    <name>A0A1Y1UIW6_9TREE</name>
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        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="8 9">
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871987.1">
        <property type="nucleotide sequence ID" value="XM_022018164.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1UIW6">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIW6"/>
    <dbReference type="GeneID" id="33559973"/>
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    <dbReference type="OrthoDB" id="1666796at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="629"/>
        </location>
    </feature>
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            <end position="357"/>
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        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00005227"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="629" mass="70890" checksum="76AE040073E00471" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ76</accession>
    <name>A0A1Y1UJ76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871531.1">
        <property type="nucleotide sequence ID" value="XM_022015463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ76"/>
    <dbReference type="GeneID" id="33557272"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ76"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="280" mass="31582" checksum="71DD1968E1995C72" modified="2017-08-30" version="1">MAYIIEKQAILVATDSKCPAGSSSSNQEVNNSEVFPPPSYDQATSEVDSSTSYPAEKESRNVIIFDGDNKRSHRRGSSSSCSSDSGESVNFEEYYQDVSFPSRQTIGVVPTVAVSSTTASYWISPCPNGAGLCECSASHGTTKSHPSSPRRIRTRWTWTYRTRHWSRRRSPRWRDANRRGSNWRLSSSGGRRGRRSYWNSNERDRSCSQWWKEPWRTDWTIRQSSRGSLRPNHGFTISKWPGSLWSVERARCSSSCKREPENAEEAAQASEEGAEGTSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJI5</accession>
    <name>A0A1Y1UJI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871323.1">
        <property type="nucleotide sequence ID" value="XM_022018227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJI5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJI5"/>
    <dbReference type="GeneID" id="33560036"/>
    <dbReference type="InParanoid" id="A0A1Y1UJI5"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="47701" checksum="48DFE40211F2BDC0" modified="2017-08-30" version="1">MTDSSIITAQGNRPLPPLPEFPLPPLLQVQDEELKAVATTHTSFYALRRDRHDWSMTQRVMDYEKLEHVGDGLLGSCVVLLLHEMFPNLREGPATILKGDLICNETLAQLADRYGISVQLRTSPAAFYATRNQVKTRASLFEAWIAAVYYSFLQHGPPDIHSEPNLIECSPRRTSSPVKGQPTSTESRQEKSRRKLINKARQDIHFKRAREEVSSASSDTSSDTTSDTESSGDESDSESSSKVAAALTFPTLTPGPPEVTSSFRPSQYAHTTSTVTTDHQNSKSSKKGDQDLRGSDDDVVTGHTCSDGQAFENLYQWFKEAFRPIAKFALQVRIDEQAKNNNITSVIDQAQEDHTAIGAKCAVDLFSKDRLGVDPVYTAVRPEGIKGIWLVTCTITEKNGRAWTAEALRSTKKFGYNLAAFRVGKQLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJM1</accession>
    <name>A0A1Y1UJM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">E1-E2 ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_650925</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871363.1">
        <property type="nucleotide sequence ID" value="XM_022018234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJM1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJM1"/>
    <dbReference type="GeneID" id="33560043"/>
    <dbReference type="InParanoid" id="A0A1Y1UJM1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1205"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1233"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="177"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="276"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX37325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1258" mass="134693" checksum="6E6F9C3B74AED628" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJT2</accession>
    <name>A0A1Y1UJT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872164.1">
        <property type="nucleotide sequence ID" value="XM_022015247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJT2"/>
    <dbReference type="GeneID" id="33557055"/>
    <dbReference type="InParanoid" id="A0A1Y1UJT2"/>
    <dbReference type="OrthoDB" id="2585541at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="122" mass="12412" checksum="9845F1CC11D06163" modified="2017-08-30" version="1">MGNCMSDPAKPPAGGKGQRLGSGSAPQSTSHAPANTHASAPPRNAAASPPRVLGGSTGDADGDARDRALKAAEERAKAAQGKGVNSSNPKAGQLSAKLAAERKSPLVQQQSNERMMDRGEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJZ6</accession>
    <name>A0A1Y1UJZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_577981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872300.1">
        <property type="nucleotide sequence ID" value="XM_022013290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJZ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJZ6"/>
    <dbReference type="GeneID" id="33555098"/>
    <dbReference type="InParanoid" id="A0A1Y1UJZ6"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="366" mass="40127" checksum="E74CA2F71D0913C8" modified="2017-08-30" version="1">MLSANAKSFWPAGTPSFQPMSPCFEDRIHPASLSVCGVHNPALLELIRTDVSREMVFYLADRATSVIACSTTIPLPPSPPPTPAKDKSPGLPTLETFIAVVCEQSNVQVSTLLATLVYLERLRHRLPKVAKGMPCTRHRVFLATLIVAAKYLNDSSPKNKHWCRYAQMFSQAEINLMEKQLLYLLDYDLAITEEEIVFNFEPFLSQYTFDSPVASTSSPVMPPTPSTPIDTIGPIRTTPRRHRRTASRGSHTYVAPPLDRSGSSSSLEADDLPLTPSQGSPLSPRKGRSVSHVHIQKPPAVYEAPSAGSYALPRSVSATVIPKAAIAPVTKDGFLGRFLRSERRRRPASKLDEEEEAVAALSWAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK85</accession>
    <name>A0A1Y1UK85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_623780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871901.1">
        <property type="nucleotide sequence ID" value="XM_022015625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK85"/>
    <dbReference type="GeneID" id="33557434"/>
    <dbReference type="InParanoid" id="A0A1Y1UK85"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="26"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="518" mass="56661" checksum="4943BDD850901A40" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKC8</accession>
    <name>A0A1Y1UKC8_9TREE</name>
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        <submittedName>
            <fullName evidence="3">YT521-B-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_588800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022013770.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UKC8"/>
    <dbReference type="GeneID" id="33555578"/>
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    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
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    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="288"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="693"/>
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            <begin position="54"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="91"/>
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        <location>
            <begin position="179"/>
            <end position="195"/>
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            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="282"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX38432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="712" mass="77461" checksum="205D6A80D4E481B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKJ5</accession>
    <name>A0A1Y1UKJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_367532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012594.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="33554402"/>
    <dbReference type="InParanoid" id="A0A1Y1UKJ5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="251" mass="27780" checksum="E5B2A17EA668A5FB" modified="2017-08-30" version="1">MQDPRATSDGTLPNAAIAEWRFKMSESVAVTDMDIQTDIPATLSFWDNAQTKQKVCKLHSFSDYKKPWFKQFPKTNGEKGSATTLSPCLGSGEGLSVESIVDLSKGFKNDGTLVSFSQHPTTTDAVTPTENCLTFTLQPTGKSNTVITLKDLKDLQKGFTNTAGYRKKQSIWDNCKSTRLAAIRLQGAQTARSVFVSDHRCCSVPLEGYDLIFCNRGLTIAELLSGPWFDTNATQGQRVSTARKRSNRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKW2</accession>
    <name>A0A1Y1UKW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_650038</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872615.1">
        <property type="nucleotide sequence ID" value="XM_022018080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKW2"/>
    <dbReference type="GeneID" id="33559889"/>
    <dbReference type="InParanoid" id="A0A1Y1UKW2"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="236" mass="25730" checksum="498B115E78860E88" modified="2017-08-30" version="1">MSSSRTPAFEHIKSAGHSETALETFALKLVRYGSLAFTASIFLLVLSSTTSSSLSWFTLHPLAQSLSVLLFSWGIAPLQPPSPSAAAERTRRFETHQSFALAGHAIFLLGSFSIAYNKYLRGAPHFTTWHGLLGIISVGLAFSQVAGGLASTWEKGKLVGGEVKGKKLYKYHRVGGYAFMTLFLFSAHLGGAHSLWATRQEGTMSLVLRVVANWIALPAVWTGLMLRLRPSKMNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKY1</accession>
    <name>A0A1Y1UKY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_621787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872571.1">
        <property type="nucleotide sequence ID" value="XM_022015408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKY1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKY1"/>
    <dbReference type="GeneID" id="33557217"/>
    <dbReference type="InParanoid" id="A0A1Y1UKY1"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="202" mass="23156" checksum="80FBDB8427B6E122" modified="2017-08-30" version="1">MTVDLDETAGPSDRPLRGLSLRRATKADLDILTDMRKECGWGWEKLPARVEKNRDWILCVFTKEVDGEIRDVGMGGWGLDWPEYPFMASRADKVVYLTSLFIRHAYQGLGLGGTAMDLLEREARDTFGGQVVTLDTARYAYDSRRDLQVGHDSNDREKVSSNLSWYVRRGYEEFRDPVPLFPDPRPDDPDYKIVAAFLRKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL51</accession>
    <name>A0A1Y1UL51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872634.1">
        <property type="nucleotide sequence ID" value="XM_022015433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL51"/>
    <dbReference type="GeneID" id="33557242"/>
    <dbReference type="InParanoid" id="A0A1Y1UL51"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="228" mass="25706" checksum="6342AA06C5E07F43" modified="2017-08-30" version="1">MTMMTDHDTEMRKTTKTASHLGHQGCSCLNSSRTRFDPKEDHTYFVETTPPLGQRFPACPTATQSGNDECREFHKRVNTLIELVQSLKSFEQSHDKTDQGYKMPSKSQPELNPNAPEDLDTWVRSGRFHHTRPTDLGSRVFIKLGPHEELRIHERYTNDTTGIFVPTVAPFTPGPSEDDFQRFHRIIMSQKSGRQGFGGSTAPHQDSVPPGDSYCGHSCRRTFASGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULK7</accession>
    <name>A0A1Y1ULK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_620831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872349.1">
        <property type="nucleotide sequence ID" value="XM_022015326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULK7"/>
    <dbReference type="FunCoup" id="A0A1Y1ULK7">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULK7"/>
    <dbReference type="GeneID" id="33557135"/>
    <dbReference type="InParanoid" id="A0A1Y1ULK7"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="281"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="402" mass="43836" checksum="43C19BB929DED5F8" modified="2017-08-30" version="1">MAVTKGVILVGGPSKGTRMRPLSLDCPKPLLPVAGKPMVWHPLSALAKVPELTEVIIIGFYEDAVMSGFIKDAKREYPNLAISYLREYRPLGTAGGLYHFRDSILRAPVPQNIFICNIDVCCSFPLAEMMDVHSKHRGVGTILGVNVKRETATQYGCIVHDPETSQVLHYVEKPESWISNMVNGGVYLFDKSLFDEIKVAMDDKTARAAEDPLIQSDEILRLEQDVIVPLAASRKMYVYQTNDFWRQMKTAASAVTASSLYLSRFLKNRPDLLAKPSSSIIAPSYVDPTATIDPSAKIGPNVAIGPNVTIGAGVRVKDAIIFEGSTLEQHACVVHSIVGANCQIGPWARVDGEPEPEKDTKGQISVTVLASEVTLAPETHVRSCIVLPNKSLSRSSANQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULL4</accession>
    <name>A0A1Y1ULL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872806.1">
        <property type="nucleotide sequence ID" value="XM_022014972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULL4"/>
    <dbReference type="GeneID" id="33556780"/>
    <dbReference type="InParanoid" id="A0A1Y1ULL4"/>
    <dbReference type="OrthoDB" id="2564134at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012417709" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14260" checksum="83D8DF9B2858A29F" modified="2017-08-30" version="1">MSSSLILFTLAIVSSYTVSAVPAPIPSPSYPECRKGYGTGYAHYDGWKLIGDDLSGAVPVSPESACVNACNRYGSACAGIFFDASISRCFLKGVHPTTWSFVRGEEDDGTDLIGGCELWSSIVGPEMDAECCNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULR7</accession>
    <name>A0A1Y1ULR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_617940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872802.1">
        <property type="nucleotide sequence ID" value="XM_022014969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULR7"/>
    <dbReference type="FunCoup" id="A0A1Y1ULR7">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULR7"/>
    <dbReference type="GeneID" id="33556777"/>
    <dbReference type="InParanoid" id="A0A1Y1ULR7"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000009">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="110"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="316"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="624" mass="69105" checksum="CF2905EDB605A186" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULX2</accession>
    <name>A0A1Y1ULX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_303474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872862.1">
        <property type="nucleotide sequence ID" value="XM_022012433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULX2"/>
    <dbReference type="GeneID" id="33554241"/>
    <dbReference type="InParanoid" id="A0A1Y1ULX2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="250" mass="28131" checksum="1C7A1EB1C6FBB397" modified="2017-08-30" version="1">MSTFLKFTGRRGWLVSNESRPGTSLEQEASILQRRNVDFGLLTVNIIVPTSFIPCTVPGRDVSQLSCLRPPYPNPHLTRICRAEHEQESREKGGRRKTPLASLSIARRFVGRPLERHTASLWSPIERTPGGAPLKAAGPVARKKNFKANVKMDSIDHPEESGSTRLTNLLRRQFGCAPHPGEAKNATTPPLVPCSRDPPRRSLRLVCVMFGGDERMDNDPPPREARKLTRVQPTLRWMLLPYIYRFGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM27</accession>
    <name>A0A1Y1UM27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-glycosylation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872964.1">
        <property type="nucleotide sequence ID" value="XM_022015039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM27"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM27"/>
    <dbReference type="GeneID" id="33556847"/>
    <dbReference type="InParanoid" id="A0A1Y1UM27"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="599" mass="65411" checksum="324CF64C09A4985F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMV3</accession>
    <name>A0A1Y1UMV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_619492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873251.1">
        <property type="nucleotide sequence ID" value="XM_022015178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMV3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMV3"/>
    <dbReference type="GeneID" id="33556986"/>
    <dbReference type="InParanoid" id="A0A1Y1UMV3"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="8">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="50579" checksum="5B37792382D31ED3" modified="2017-08-30" version="1">MSAVSSSWSPPVPSSSDHHWEEDEAEVDASIPSTPIDGPEDFIPAPWTRTKPKSEPDAPLRSLDDEDDQDDQDEPLHSIDADDDDVPSPSEDRQCRICFAGVDDEPTSGKLISPCLCTGSMRYVHVNCINAWRGTGSNAKAFLECPQCHHQYRLRRTLVSGLATSRPVLFILTTILFTILTILNGALLHFGLHTLPSIREKIFTARTPVSNVFDFNKDEDDYWVNDSTVIIVGGGGTLIYDIVLGSIQMFTALAIQFAHTQSVIFDMIPDPVEEAFFWLGIRFLLGLAVMGSFSFLSMLISFSLFGPLQIINSFRGIGFFRNFRRRTEGRSINQVVIIAFVLIGTIRTLFQVYGWVKRQTHRMLVYVETQILEVNSEDRRKAREEAIREREASWTRRWWRERRYNTWRGWWEMLLRVSILLKIRATDKWEAFKARLRPELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNG1</accession>
    <name>A0A1Y1UNG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_618378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872920.1">
        <property type="nucleotide sequence ID" value="XM_022015021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNG1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNG1"/>
    <dbReference type="GeneID" id="33556829"/>
    <dbReference type="InParanoid" id="A0A1Y1UNG1"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="123" mass="12843" checksum="D53951B6AD46A370" modified="2017-08-30" version="1">MSLARFTRASTAPLRTLQLRAISTSAVRSKSLTDSVKETADAVNKKVGQTLASGLEGAQNAADSVKETVGVRADQAKAKVDANTPTKNQVKGAADYVKQTVNEAAADAKVEANKAKQDAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNV7</accession>
    <name>A0A1Y1UNV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_576463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873467.1">
        <property type="nucleotide sequence ID" value="XM_022013189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNV7"/>
    <dbReference type="FunCoup" id="A0A1Y1UNV7">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNV7"/>
    <dbReference type="GeneID" id="33554997"/>
    <dbReference type="InParanoid" id="A0A1Y1UNV7"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="162" mass="17406" checksum="4AA77A3079AC62F7" modified="2017-08-30" version="1">MSNCYFDIAINNQPAGRIVFELFDQTVPKTADNFRALCTGEKGFGYAGSGFHRVIPNFMLQGGDFTAHNGTGGKSIYGNKFADENFKLRHTEPGLLSMANAGPNTNGSQFFITTVVTSWLDGKHVVFGKVVDGMPLVKKIESYGSDSGKPKAKITITASGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP56</accession>
    <name>A0A1Y1UP56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_575923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873603.1">
        <property type="nucleotide sequence ID" value="XM_022013155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP56"/>
    <dbReference type="FunCoup" id="A0A1Y1UP56">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP56"/>
    <dbReference type="GeneID" id="33554963"/>
    <dbReference type="InParanoid" id="A0A1Y1UP56"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="405" mass="44892" checksum="579CACA38D0E15C6" modified="2017-08-30" version="1">MSGAISSPSTPSRQGKRHGIAFGQVIIGPPGAGKSTYAHGMQQFLTALGRPCHVVNLDPATPSPSYPCSVNITDLISLESVMREYGLGPNGAMLYVAEYLEANLDWLVDRLDELLLQEGTLVPGYVIFDTPGQVELWTNHDSFKRVIERLTKMDHRLVAVHLSDAHYITDASKFISVALLALRATLQLELPHVNVLSKIDLLSTYGELPFDLRYYTECRDLEYLLDSLDIDTRPNPKMKALNRAMVELVEQYGAVHFETLAVEDKRSMLKLVRIIDQAIGYVSLPGSVSTLGDTTLNEKASHVGGDFLRNMPTLDDLGDVDDVQERWGARKAQHDEEEMEAWGREWEMRRAASGKEYGEGDGAAAEKDEEEESDADEQVFRGMERAMPLSGMAAQVVRPSAAHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP73</accession>
    <name>A0A1Y1UP73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873139.1">
        <property type="nucleotide sequence ID" value="XM_022017978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP73"/>
    <dbReference type="GeneID" id="33559787"/>
    <dbReference type="InParanoid" id="A0A1Y1UP73"/>
    <dbReference type="OrthoDB" id="10667933at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="423" mass="47000" checksum="9A469BFA81E2220C" modified="2017-08-30" version="1">MVNLDNYLCSTLRRMAIDRGMANAHKAKKIGLIQFLESHTEDAPEAVAIEPAPRNSQGPAPPQPDHIDQDGMHAMASRVAALETVIQGLADRLSQIAPTDTRPLDPRVMMDAFGAALSGIGATTLEAVMELAPHVSQDLVRLIASRRLPVWEFWRLDPEKVTVVQKARPYDPEQDQEQSFDAARTRYRTFGDILRPWLIYALVRDCLVSGQGRYLIMHLYEILRVVESTRAGPHKFASILNWHFKVVEERLNHGDDNFDERVWIRPDPEAINRYVTNYAPSPQRLPVTPETPVPQTNRTFQRPNLPWRAEQYGSLTSDDICHRYNLRQECPGPLCIFRHACSGCGKDLRPVVDCDCQHSALQNLNNSTEPVASGSGSGDGSGSGSGSSSFMETNTVSRPGPSSTVLHTGRLPPKPFAGPWPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPE3</accession>
    <name>A0A1Y1UPE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_615448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873686.1">
        <property type="nucleotide sequence ID" value="XM_022014721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPE3"/>
    <dbReference type="FunCoup" id="A0A1Y1UPE3">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPE3"/>
    <dbReference type="GeneID" id="33556529"/>
    <dbReference type="InParanoid" id="A0A1Y1UPE3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="39140" checksum="BF2D6AED29B7F650" modified="2017-08-30" version="1">MNNDSLALALDRFSFYAKDAMLSLTQCICKPDATLKINGRSYKIEKLLGEGGFSFVYLVQDTSSGRKFALKKILITSGPEGVAEAMKEVEAYRRFRHPNIIKILDSAVVQDPAGEGKIIYLFLPYYSQGNLQDTMTRSSISGEPLSDQRILQIFLQTCMAVEAMHRYRLPSTSAYPPAQSNSGELDPVFDGDEDLQGADAGEMIPYAHRDIKPGNIMLADDGSAILMDFGSTVKARIPIETRQQALLQQDLAGEQSTMPYRAPELFDVRTGTTLDEKVDIWSLGCTLFAIRYGRSPFEIDGSSIAMAAGSGRYTHPPGASRILVGLIDKILVVDPTHRPDIEGVIALTKKAIQEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPP5</accession>
    <name>A0A1Y1UPP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873778.1">
        <property type="nucleotide sequence ID" value="XM_022014762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPP5"/>
    <dbReference type="FunCoup" id="A0A1Y1UPP5">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPP5"/>
    <dbReference type="GeneID" id="33556570"/>
    <dbReference type="InParanoid" id="A0A1Y1UPP5"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="41764" checksum="D88F02B95FB67736" modified="2017-08-30" version="1" fragment="single">MNGLHRASLHLPTRTMPKNIVIIGGGIAGSTTAYYLSQSTSRSPDTKITIVEGTKIAAAASGYSGGFLAKDWHGSATSSLAALSFDLHAKLAKQYGGAEKWGYRTVDTLSIETDATRTAKRQTPVKWLPQGLVHMSRSLGTHSTTAQVHPRLFTTFIADQFTQAPNTSIVIGTAVSLCMSSNESGSSTFSPTGVKVRLQSGEEEVLPADVVVITAGPWTGQVAIDLLGNQIGRRLGVSGHRAHSIVLKTKEQLTPHCLFTNMRLEDDSVAEPEVYARPDGTTYICGAGDSEPLPATAAEVKPSPISIEKLKREAAALSSVFSEEGGVEVQAEQACYLPIADRGRPLIGKVRGVEGVYVGSGLTCWGITFGPGTGCLLAEMILNGTARSADISKLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPS6</accession>
    <name>A0A1Y1UPS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_649234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873008.1">
        <property type="nucleotide sequence ID" value="XM_022017959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPS6"/>
    <dbReference type="GeneID" id="33559768"/>
    <dbReference type="InParanoid" id="A0A1Y1UPS6"/>
    <dbReference type="OrthoDB" id="2568964at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="276" mass="31815" checksum="8E5799391F25D8AB" modified="2017-08-30" version="1">MTNPDTSVRYFLSPQTLRIEACRCLNPRDPPQTAPATIDYMLRRLDKLWSRMRGWRLDPKVRLAAERLLIQLRRQGMELFHLVGVNKGTHAQGSKTRGGMAILLLFPDWGEVYADPVEEDAEAQRRKAFFESNPDGEDRTVIACGYGHRIVAEINVLLHKEIRSDGIVDRIDTRLAHDWSDTISVADYEYYREEGAPPASQLLVTGGEDDEKMIRMVWQQVNVRMSNKWTRYEKDFGKSLKRVAVELLTDGFRTHAYEVERVIKALRMEVGVHLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQM1</accession>
    <name>A0A1Y1UQM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_332783</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873308.1">
        <property type="nucleotide sequence ID" value="XM_022012510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQM1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQM1"/>
    <dbReference type="GeneID" id="33554318"/>
    <dbReference type="InParanoid" id="A0A1Y1UQM1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX39445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="453" mass="50167" checksum="7176F915A3B6CA11" modified="2017-08-30" version="1">MGREIVSVSVGQAGNQIAQAFWLNILEEHGLDKNGKYTGNDQQQLDKVDVYFTEASNRKWVPRSIQIDLEPAVLDTIKAGPLSNLFRPDTFVHGESGAGNNWAKGYYTEGAELVDPVLDVLRAQAEAADSLQGFQVLHSLGGGTGSGLGSLLLGKIREEYPDRMLATFSVFPAPSVSETVVEPYNAVLSTNNLVENSDITCCIDNEALYAICNTELKLKEPQYKDLNQLIAKVMAGFTTTLRFPGVLNSDLRKLAVNMVPFPRLHFFTAGYAPLVASHTKSFTSSRVHDLTSAIFQKKSLLAAIDPAMGKYLTVSVAYRGKLSMRDLENAVYEYQNKNSTLFVPWIPNSSLTTLCTVPPRDQPAAATLVANTTAIAEVFKRSHAQFRSLFKRRAYTHWYTGEGMDEMEFTEAEGNLADLCTEYDQYANAEIDDEEYAEEVPVEEEMGEEVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR69</accession>
    <name>A0A1Y1UR69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_616170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873862.1">
        <property type="nucleotide sequence ID" value="XM_022014799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR69"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR69"/>
    <dbReference type="GeneID" id="33556607"/>
    <dbReference type="InParanoid" id="A0A1Y1UR69"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="215"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="466" mass="51867" checksum="0A5A96DE67ABF89E" modified="2017-08-30" version="1">MSAPVPRLRGHLLRSAASLAGASSRIGEPSVSKNCSCGRFVGSSTIPARSIGRSLLVSAFDAGRNCHARAYSTDSIGKAGPDASSSLAGSSTSSSNFQDARYQHFQASLANIDANNQSRARVFKGVHSRRDRAKGTTPQEAKALNQVIAGLYRELERLGGPLRPGSNPVTDPFSHNLADSPRSGDSLRSMIGVPRFAKRTDDGLGGAELAKLRSEIDMLKEDMSTLSSEQDLVEWAERHVFTPSEVSDGEELGYPRRYPHMLAYLMRITREIYRNPSLALAFFQHAQTLSLESYMSGCLTSAYNELIRTRWQCFRDLEGVDQALKEMETSGVSWNFHTRQLVESVCNSVSSTPFSTERGEEESIWKEFVMKRWRTLEARLDADSNASEGMWDRMAEAKRMERGLNLDSERARERYGSSDNRQKGGIIPQSQRRPERRSSESLSHNSVYQDEWQAGHDEDAPHRAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR74</accession>
    <name>A0A1Y1UR74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_678759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873430.1">
        <property type="nucleotide sequence ID" value="XM_022019012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR74"/>
    <dbReference type="GeneID" id="33560821"/>
    <dbReference type="InParanoid" id="A0A1Y1UR74"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="272" mass="30513" checksum="A9071AB26B4964FB" modified="2017-08-30" version="1">MPRRDSEPSIPLNDLFYSHDEDGTTRKLDTDDLKELSAQFENTVAAKKWLINQATAAEVQPYLDKYTKALTSKPQTLDHDVDPDELAIRTYKDRSLWLDEAERVMEDDPGYVIFDSVLAFHDMLHRLDDQVDEASQRYEAMSNTSSETVQLNDKTAQPLSNEREVETGKTNETVTTIQGGDEMGDSEQNQISVVADGGLRQKLKHYHAEIEAAHERYEEIVLEVSEGSGIDQVMANAYLEEVKRMTVELESISDIISPAVSSGQANAAETNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR75</accession>
    <name>A0A1Y1UR75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_677915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874121.1">
        <property type="nucleotide sequence ID" value="XM_022018959.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR75"/>
    <dbReference type="GeneID" id="33560768"/>
    <dbReference type="InParanoid" id="A0A1Y1UR75"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000157">
        <property type="entry name" value="Alpha-1,3-glucan synthase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1273"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1305"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1558"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1607"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="domain" description="Mok11-13/Ags1-like Ig-like beta-sandwich" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Mok11-13/Ags1-like second Ig-like beta-sandwich" evidence="12">
        <location>
            <begin position="92"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Mok11-13/Ags1-like CBM" evidence="13">
        <location>
            <begin position="191"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Starch synthase catalytic" evidence="10">
        <location>
            <begin position="391"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="682"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like transmembrane" evidence="14">
        <location>
            <begin position="1207"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="888"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX40442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1638" mass="184149" checksum="2494C2736F33C011" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URC4</accession>
    <name>A0A1Y1URC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein 9/12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_610949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874161.1">
        <property type="nucleotide sequence ID" value="XM_022014227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URC4"/>
    <dbReference type="STRING" id="4999.A0A1Y1URC4"/>
    <dbReference type="GeneID" id="33556035"/>
    <dbReference type="InParanoid" id="A0A1Y1URC4"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="89" mass="9350" checksum="03E2243128884F14" modified="2017-08-30" version="1">MSDMGRQSFGDKAEAALKPDSQKSYLEQAKDTIAGKADSAASSAQPESQKSWTQQAGDAISGNQNENSGSLLDKAKDALGMNENKPTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URM3</accession>
    <name>A0A1Y1URM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="29" type="ORF">BD324DRAFT_597351</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873590.1">
        <property type="nucleotide sequence ID" value="XM_022013879.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1URM3">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URM3"/>
    <dbReference type="GeneID" id="33555687"/>
    <dbReference type="InParanoid" id="A0A1Y1URM3"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
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            <position position="1200"/>
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            <name>Zn(2+)</name>
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            <name>Zn(2+)</name>
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            <position position="364"/>
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            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        <location>
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        <ligand>
            <name>ATP</name>
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            <dbReference type="Pfam" id="PF08501"/>
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            <dbReference type="Pfam" id="PF24621"/>
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        <source>
            <dbReference type="EMBL" id="ORX39805.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
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    <sequence length="1594" mass="170766" checksum="94685E7BEDB04437" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US49</accession>
    <name>A0A1Y1US49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_617342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022014912.1"/>
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    <dbReference type="InParanoid" id="A0A1Y1US49"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="202"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="599"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="766"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="987" mass="105123" checksum="72EADF52B982FDFF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US53</accession>
    <name>A0A1Y1US53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_574665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874539.1">
        <property type="nucleotide sequence ID" value="XM_022013076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US53"/>
    <dbReference type="GeneID" id="33554884"/>
    <dbReference type="InParanoid" id="A0A1Y1US53"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="703" mass="74505" checksum="5C049D22B077DD53" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USC9</accession>
    <name>A0A1Y1USC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_612577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874609.1">
        <property type="nucleotide sequence ID" value="XM_022014407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USC9"/>
    <dbReference type="FunCoup" id="A0A1Y1USC9">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USC9"/>
    <dbReference type="GeneID" id="33556215"/>
    <dbReference type="InParanoid" id="A0A1Y1USC9"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028071" evidence="12">
        <location>
            <begin position="20"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="109"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="315" mass="34485" checksum="728EDB4F1F419720" modified="2017-08-30" version="1">MSLSLWESFMCGGLAGCAAVTVSNTPEVMKTRLQLQGELQKADSNVPKVYKNVLDVFQKTWRNEGIKGLQRGLFPAYGYQILLNGSRLGFYDPIRRTLNRVVGIDPTVVNMGTALTAGALTGCIGAALGSPLFLVKARLQAYSPALPVGAQHYYRNSRHALSSIYREGGLKGLWRGVNTAILRTACGSAVQLPSYNFGKTLLVQNGWKDNSYGTYFVASAVSGLCVLLAMQPADTVLTRMYNQNTVKDPVTGAIRGALYSNPIDCLWKTLKTEGIRGWYKGTTAHFARIWPHTVVTLVANEVIMSQYKGLRAKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USH1</accession>
    <name>A0A1Y1USH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1014-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_612691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874640.1">
        <property type="nucleotide sequence ID" value="XM_022014425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USH1"/>
    <dbReference type="FunCoup" id="A0A1Y1USH1">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USH1"/>
    <dbReference type="GeneID" id="33556233"/>
    <dbReference type="InParanoid" id="A0A1Y1USH1"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="131"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27398" checksum="C89D7678342602D7" modified="2017-08-30" version="1">MPPSKNNTKKESGRAKKAENEEKKSQAAAKAQEAKEAEKWKDGAKGTTKADLAAVKAAEQAKKKAEKEALLAAEEASMPSKPKAAPKAGAKKKPTTDKPLLAPGGGIANYSVNDPLGLRRSNADQAGEGSTTALSATGVEDMLEALELANQKTDKDTMGAKAGLIERHPERRFKAAFEAYLEREMPRIREDYPGLRQNQYRDRLFKEFEKHPDNPFNQAQVAYNATKDERVDALKQVMDAREAKYRVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USM2</accession>
    <name>A0A1Y1USM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_677982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874203.1">
        <property type="nucleotide sequence ID" value="XM_022018966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USM2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USM2"/>
    <dbReference type="GeneID" id="33560775"/>
    <dbReference type="InParanoid" id="A0A1Y1USM2"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="466" mass="54107" checksum="B02AB535EA60D27C" modified="2017-08-30" version="1">MSLNSVVNNLVRAAAGIPQDISDSDLDAHVAKLLAEEAKNKEKSWSELGLSGLLREGGKDSPDPNAPKPNKRFLASVIRTVDGHNSALLRAQAAAARDARVSRGDSSGAGSSRLFGGAMRSVGRNDRLAREKRRDVDDRVYREREEREKESRRRYDTRDHINRGERSRRDDLDEEEYLNRRESRRREEDRRSRHRKRREEEDEEAYFNDDEKRGGREEDERYRKIRKEQQDRGDHWTERLKERYRERDEEPWSPGKDRSRRKERNESRSPRKEKRSPSPRKEESRRRDSDGEEETLNESVSRAKTSRVKGKSPIRTVQDAGLFAGSSSPPSNLSKMDKYFHTSYDPRLDLGEVPKEGMVAEVGWDNMLAVLKERGQKRRHQSPTLSDDGYAIPKNVSLRKDSPEIDIRKLEKAEKKKRKEDRRKRRGDSDSDDEKDKKAKATTETPGLFDIPYVKKGGVREWDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USX3</accession>
    <name>A0A1Y1USX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIGR02453 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874798.1">
        <property type="nucleotide sequence ID" value="XM_022014483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USX3"/>
    <dbReference type="STRING" id="4999.A0A1Y1USX3"/>
    <dbReference type="GeneID" id="33556291"/>
    <dbReference type="InParanoid" id="A0A1Y1USX3"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51188" checksum="7D903AC777587D0A" modified="2017-08-30" version="1">MAITPRSTRSATRSSPRSIKSAKSASSKPSTPLKKVTTAKTSGKKAPTARTSPYFQKTSKQVKGKGKRTKRQAEEDGSEDDGDRADSPTGMTETPSSSDAEDSEDDFNLESDDAEEPEEEIESDVDSDFLDEEDVPVKKKSRPSNGSGKVPTSSSKGKGKAKRVEIDGYEDEEEEEDMEVELEEGQEIAGRIYPAPKTGQVPPGQISQNTLNFLKNLQIPERNDRDWFRSHEPAFRQAENEWKAFVTQVQMKFQEGDHEVPILPPKDVIHRIYRDVRFSSDKTPYKKSFSLSTSRGGRKGIWAGYHLSISPNDKSILACGTWQPGKNELASIRHRFLTDPELFREVISAPEFVEHFGPPKPHPKGKRQNVFGHDDALKVAPKGVDKSHKDIDLLKLRSIAVIHHFSDNEVLKKDFQDQVGELVRVMAPFVHLLNDFISVPAGDNDDDDEDENGNEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USZ8</accession>
    <name>A0A1Y1USZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ima1 N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_647969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874751.1">
        <property type="nucleotide sequence ID" value="XM_022017754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USZ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1USZ8"/>
    <dbReference type="GeneID" id="33559563"/>
    <dbReference type="InParanoid" id="A0A1Y1USZ8"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="475" mass="52686" checksum="FE610EAE017DF7CB" modified="2017-08-30" version="1">MPFLRSSTRPRAVECFFCLSASLLPPSGLVTNRKGKGRASAKSLETEWNWHCDRCGCWNIKDKNGHMVSDLPAMHNSNLNQQSFSLRARPSSSHLPSASASASPCCHSCLANQTLIMNMLANYLPDDSDPSFHALYAALPTYISNLHSRYPPVCPECQPSVEAALRKSDLKAQTEAWGSALQRGTGRHSATRQATYVGWLDVVVWRIKGVLFILGCAFSWGQGITSAARSLRMYEQTHYTGHSHFNHVVLAYHVCSALWMTWDPNWLSRSRHRLRTSSSGRRKWIICMFTILLLRIAGASSFLWSLKTPVDDTLRTICVSLEMAIFIYALSSLPAVGPVPLKLVRPVPVQVHSPTHNATPPPAIGSLSLSNDSIKVHNPVFGKSSFVTETEEDHVEMMDWEPVNTSGQTHDPDLTPMHERSAGDWDTFATGRQSMFPRQTEETGLESLLASWRISNSTDEGIHGDEAQAQKCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU58</accession>
    <name>A0A1Y1UU58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_678486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874773.1">
        <property type="nucleotide sequence ID" value="XM_022018999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU58"/>
    <dbReference type="STRING" id="4999.A0A1Y1UU58"/>
    <dbReference type="GeneID" id="33560808"/>
    <dbReference type="InParanoid" id="A0A1Y1UU58"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX41094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="695" mass="75487" checksum="7F174DD1520CA933" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU80</accession>
    <name>A0A1Y1UU80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874793.1">
        <property type="nucleotide sequence ID" value="XM_022014481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU80"/>
    <dbReference type="STRING" id="4999.A0A1Y1UU80"/>
    <dbReference type="GeneID" id="33556289"/>
    <dbReference type="InParanoid" id="A0A1Y1UU80"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="324"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="383" mass="36736" checksum="4933890A7364AC1D" modified="2017-08-30" version="1">MTCVMTTDSKCTPDQWFNQRTNDCNELSWAIDPPASNPPSGRNCPTGWFWYDTRGNCQSISPRSPAPDCDNWNDKQLVCGSDPTARSLPSGAGGGSGGGSHGGSWSSGGSSGGSSSSGGSSGGSWSSGGSSGGSSSSGGSSGESSGSGGSSGGGFNWGQGGGKQGHSGWSQGGGHGEGHGGQGGQGGGWGKGGGSGEGHGGQGGQGGGGSKGGGSGEGSKGGGSGEGHGGGGSKGGAGQGGGGGGGGDHGQGGKGGGKDCGKRGINGTETSNSTNPTSTKRDFLGRQNILITRDNTQSELDKIYCPDGLHACSVNTPSGGAWAYECLDWLTELVSCGGCLSDGAGKDCSAIPNTASVGCEAGDCIIYSCKPGFGLNGTDCVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UVM7</accession>
    <name>A0A1Y1UVM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_606867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874964.1">
        <property type="nucleotide sequence ID" value="XM_022014033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UVM7"/>
    <dbReference type="FunCoup" id="A0A1Y1UVM7">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UVM7"/>
    <dbReference type="GeneID" id="33555841"/>
    <dbReference type="InParanoid" id="A0A1Y1UVM7"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="119"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX41285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="615" mass="68428" checksum="391F81E3F3A6C5FC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5L5</accession>
    <name>A0A1Y1U5L5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_640162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000026">
        <property type="protein sequence ID" value="ORX33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867669.1">
        <property type="nucleotide sequence ID" value="XM_022017325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5L5"/>
    <dbReference type="GeneID" id="33559134"/>
    <dbReference type="InParanoid" id="A0A1Y1U5L5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="294" mass="33183" checksum="B4D5FEDAE9E10EA1" modified="2017-08-30" version="1">MIPSTSWTDEDWRVYMDTLPFDKITTKNPPLKTLKSVLPSPDTVPDDPHPVAALDASHPEDILLQPENMAVFKCAYLPHSLDTWGCAPKEEEDVWPAYGYTHPGVRCRNVGAACTVIVRIQAVDHSPWSSIVLDPCWHCEVKGQACSVAKSALFKGGEYHPAQAPRPRREPKRRRMEVYNVCKEVWLRLTLDRPVDHPAASNQTKRIDLLPICHLSLKAARSLVRRALQTRLSHYVPLSPTFTSLSTFCRPLCTISWIDQALNAPLPLTRSSRIGDGPILGRIWYVILQKRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U639</accession>
    <name>A0A1Y1U639_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_654172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867797.1">
        <property type="nucleotide sequence ID" value="XM_022018763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U639"/>
    <dbReference type="STRING" id="4999.A0A1Y1U639"/>
    <dbReference type="GeneID" id="33560572"/>
    <dbReference type="InParanoid" id="A0A1Y1U639"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="129"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="250"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="553"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="673" mass="74405" checksum="2168CFB8E7EB5961" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6M1</accession>
    <name>A0A1Y1U6M1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_595477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867991.1">
        <property type="nucleotide sequence ID" value="XM_022013846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6M1"/>
    <dbReference type="FunCoup" id="A0A1Y1U6M1">
        <property type="interactions" value="879"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6M1"/>
    <dbReference type="GeneID" id="33555654"/>
    <dbReference type="InParanoid" id="A0A1Y1U6M1"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="162"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="637" mass="70049" checksum="1BABD037AC9951C9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6T2</accession>
    <name>A0A1Y1U6T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_653802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868048.1">
        <property type="nucleotide sequence ID" value="XM_022018711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6T2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6T2"/>
    <dbReference type="GeneID" id="33560520"/>
    <dbReference type="InParanoid" id="A0A1Y1U6T2"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="661"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="825" mass="89039" checksum="7DBB765963D0B63E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U709</accession>
    <name>A0A1Y1U709_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Afadin and alpha-actinin-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_198963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868081.1">
        <property type="nucleotide sequence ID" value="XM_022012160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U709"/>
    <dbReference type="STRING" id="4999.A0A1Y1U709"/>
    <dbReference type="GeneID" id="33553968"/>
    <dbReference type="InParanoid" id="A0A1Y1U709"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF4">
        <property type="entry name" value="SSX FAMILY MEMBER 2 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="654" mass="72388" checksum="7A93BD45084D7814" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7B1</accession>
    <name>A0A1Y1U7B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_639716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867751.1">
        <property type="nucleotide sequence ID" value="XM_022017273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7B1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7B1"/>
    <dbReference type="GeneID" id="33559082"/>
    <dbReference type="InParanoid" id="A0A1Y1U7B1"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="840" mass="93488" checksum="E9541FA63C0331A3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7E8</accession>
    <name>A0A1Y1U7E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BD324DRAFT_585143</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867762.1">
        <property type="nucleotide sequence ID" value="XM_022013721.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U7E8">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7E8"/>
    <dbReference type="GeneID" id="33555529"/>
    <dbReference type="InParanoid" id="A0A1Y1U7E8"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
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        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
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    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
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    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
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        <property type="entry name" value="DPOD/Z_N"/>
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    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
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    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
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    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="12 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="25">
        <location>
            <begin position="76"/>
            <end position="171"/>
        </location>
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    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
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            <begin position="1034"/>
            <end position="1231"/>
        </location>
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            <begin position="1297"/>
            <end position="1743"/>
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    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
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            <begin position="1784"/>
            <end position="1853"/>
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        <location>
            <begin position="321"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="423"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
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            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="610"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="662"/>
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    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="735"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="442"/>
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    </feature>
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        <location>
            <begin position="460"/>
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        </location>
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        <location>
            <begin position="560"/>
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        </location>
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            <begin position="620"/>
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            <begin position="662"/>
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        <location>
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            <begin position="741"/>
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            <dbReference type="Pfam" id="PF24055"/>
        </source>
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            <dbReference type="EMBL" id="ORX33427.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1894" mass="212994" checksum="718968CD67B2F8CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7X6</accession>
    <name>A0A1Y1U7X6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GCS light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_166633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022012070.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:glutathione biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Gclm"/>
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    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43566" checksum="637E8EB92B6031D6" modified="2017-08-30" version="1">MAQSSSTSDASTTHLPSLLIFTGSHHPLPRKYPHPHKPILLIPPFMHRTLHAALDQTPPATSTTSDGTLIIPHPDNIIKHDLPELAADRTGIDEKPHGQTNDASTTLDTAQPLSTVAEDGFSRSDDIDAEVTVKLHLVGSSTSSSTRLEWITKALTSLAEFKGLKEVDTLLLGFKGVDYRGQKSEAATVLGCGTEGMESGSGGEVVDEQVASEVVDTWRALIKAKGASSKGLPNGSSAPDGHSIPTVDLEQAVKHVKILGTLYMPLSLLETLSEDAAQAPTINSMDTPDCHHLPREYLDFARERGIELWAGGGGEGSDPMPDRELHNVLQEFNSSLIPIIPSLSEREPPLLENLIPLREDGLKYDPNVEPDLRVNWVLGYTLVSKTRNVVKDKGYIVSADWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Z2</accession>
    <name>A0A1Y1U7Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3'-5' RNA exonuclease USB1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_209271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867946.1">
        <property type="nucleotide sequence ID" value="XM_022012183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Z2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Z2"/>
    <dbReference type="GeneID" id="33553991"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Z2"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="280" mass="31317" checksum="0FA7B01AD8538350" modified="2017-08-30" version="1">MGLVEYESDESEDEKPPENTVLPVKTSKRAPRSPGELHIQSVSSPMPDFANLPGDPRDDPSLHQGRKRTRPFVDGDHDAHVYISLSVSNRLRQALENIIARARVLCPNITLVSLLESQYLHISLTHPLPLRRSQIEPVASSVTRLLRASASRPFRLAFAGDLKVYYNGRQTGGQGTGGRAFLAFQIGAGHPEINDLLERVIHPVLDTLHLPRYHTNPEFHASFAWCLDTETPISQAVVRQLNDELKDAFLLSQPTDGWLIHELMYKAGNTLRSIALHHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8B9</accession>
    <name>A0A1Y1U8B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsular associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_637370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868559.1">
        <property type="nucleotide sequence ID" value="XM_022016997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8B9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8B9"/>
    <dbReference type="GeneID" id="33558806"/>
    <dbReference type="InParanoid" id="A0A1Y1U8B9"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="526" mass="57357" checksum="44372D62AC49F720" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8D6</accession>
    <name>A0A1Y1U8D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_176786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868556.1">
        <property type="nucleotide sequence ID" value="XM_022012103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8D6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8D6"/>
    <dbReference type="GeneID" id="33553911"/>
    <dbReference type="InParanoid" id="A0A1Y1U8D6"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="456"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="477"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="513"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="589"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="697"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="733"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1051" mass="111277" checksum="BE7BF10B37F1EAC7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8N0</accession>
    <name>A0A1Y1U8N0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_206135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868155.1">
        <property type="nucleotide sequence ID" value="XM_022012177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8N0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8N0"/>
    <dbReference type="GeneID" id="33553985"/>
    <dbReference type="InParanoid" id="A0A1Y1U8N0"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214735" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="52547" checksum="F61CC7CD787F7433" modified="2017-08-30" version="1">MRASTFLTILSSLTASLAVPQSRNSQPRHVRKVSIRQDHVHTEPIVIVPRTYGDAAAGYEGSMPPAMGMAEGACGDQGCGGEMAAPPSMTYEAAPAMEKTMMESAPPPVETTMMHEAASPPPPMETMQAMDKMVTEISDMNSCMQMCQAHFGGGMNEPMGMGETGSGQVMVNESAPTATEAPAAGMTHTIIVAPTKGVLRFVPFAVTAQKGDMLHFIWGAGPVSAQSNNRTHLTRFVDQHSSTLSLGTNVCNKSTTTDAFDSGKLNASATFDTMFTGDTSSPQFHYCTVGKHCASGVFGVVNPPTTNVTNDLTNMATATLTETAPAPGGTAGSGSAGCQGNSMDCWIERWMQGSPEAQATGTAVKEACSSQPAAWSWGGNFDMSTVESESLPRKTIIENVMYTRLMMSMNPSMLQPGVMTSDNFTAPPDLNSFVAQATGVNSTVSTSASPAGSSVSSSISGSAPSSTDSAAAAQADAAKASGEAYPRVSLVSSAMFGLVGLIAAWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8T8</accession>
    <name>A0A1Y1U8T8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_610286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868185.1">
        <property type="nucleotide sequence ID" value="XM_022014196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8T8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8T8"/>
    <dbReference type="GeneID" id="33556004"/>
    <dbReference type="InParanoid" id="A0A1Y1U8T8"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="150"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="272" mass="30767" checksum="22D9DCF7DF9D03DF" modified="2017-08-30" version="1">MLNNAPQLLHHVSTPNIPLSHRRSIGQVRFQLPREDEEDERQEFELERLTRKSSSSLTHVSAGRNVYIHSVPADYTETSLTEYASRFGKAVQARCKPVGEPRDNVPVRQFEQREEAEAFLRALQSRGITSAFGKDDYQLEHKAREDRESSNLYINGLPLTTTEEQLKRLLAPYGTVASFKFLTDNEGIRRGPCMARLLSRPQADAAVQALNNVSIGSGRVLQVRIADSKDQKELKRDTATTKNLDSRSTIDVRMRQDSMPTSWASSRRQGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8U3</accession>
    <name>A0A1Y1U8U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_584143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868204.1">
        <property type="nucleotide sequence ID" value="XM_022013660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8U3"/>
    <dbReference type="GeneID" id="33555468"/>
    <dbReference type="InParanoid" id="A0A1Y1U8U3"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="41"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="285"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="438" mass="47673" checksum="52F3263BA5F75FC9" modified="2017-08-30" version="1" fragment="single">VIQSTPSLLLSLVGLVFTGELLEHVARWRVFRRVDELFILVPMIGNLKGNLEMCLSARLGTSANIGELDHRMTRRALLMANMTLLCLQALLISSLAAFLSFFLGLITRHRLGDKMEPSGGFGDDAGLGVDDGEWHEGYTRPGWKQLVMVLATGMGAAGFSAFVLGNFMSALVVVSRWTGMDPDNITPPLAACLGDLMTLFILAGIGTLLVGMMDTPVPLLTVILMCVAVGWFARRVMQNDWIRKVAKGAWAPLIAAMLIASGAGMVLDQGVGKYRGFALLSISMGGLTGSIGAIHANRLSTSLHTKLHIRSPSQSHHPPFRTDQLSPLHNMLVLYLLAFPCQACFLLFVQWAGWIDLSLAWAGWLCFALTAGISLVLAHYLTLFFWAHDLDPDSYTLPIHSALVDFLGSMLLMLAYEICIYTGRDVVTHIVETESGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9B9</accession>
    <name>A0A1Y1U9B9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868871.1">
        <property type="nucleotide sequence ID" value="XM_022018575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9B9"/>
    <dbReference type="GeneID" id="33560384"/>
    <dbReference type="InParanoid" id="A0A1Y1U9B9"/>
    <dbReference type="OrthoDB" id="2580011at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019251">
        <property type="entry name" value="DUF2231_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09990">
        <property type="entry name" value="DUF2231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2231" evidence="2">
        <location>
            <begin position="35"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="215" mass="23157" checksum="915BFF1284717E59" modified="2017-08-30" version="1">MTATTRAAEKAEEIASDSADLLAGQVPGDPDKAVGHPLHPATVHWPIAFLTACFGLTTITLLPANLYPSFFLPPPSAIPSLVHYSAGAAVLSSVPAIVTGAGEAYKLAKKEYKEKGSWEAVFDNSWNMKDDGGRKLKMTVKHASLNDVVIFLAAYNWYHGWAHPYDPIPAIVLALNAVAFPALLYSAMLGGRMVYEYGMGVQRQGAGKQVREKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9I7</accession>
    <name>A0A1Y1U9I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TLC domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_584583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868054.1">
        <property type="nucleotide sequence ID" value="XM_022013690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9I7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9I7"/>
    <dbReference type="GeneID" id="33555498"/>
    <dbReference type="InParanoid" id="A0A1Y1U9I7"/>
    <dbReference type="OrthoDB" id="341353at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43468" checksum="CE94A5CBEB26F1EE" modified="2017-08-30" version="1">MSLPTSAIMPVSIYTCLCAAYCIFAPFFSTTRKRAYILSVISSSIMSSVSLPYVYLYLRYGLHGAYKMSQNGWLEELGRFATAFFGTYLFADLTLGYLMYKSEIGLLTGWVHHTVYIGLMIYLNMVSESPVFLIAGIMEVPTLDLGLSNLFPQVRNDVRFLSSFFIIRIVFNLYFALDCARPSSRVIFDNAWMPTVMLSLALCLHVMWFKGGIVGYLKRQSKTSKSGSTSAVSEIMENPGLSIPATDSCPESPEDSPLITPHTIPLTPSASATSQKDNSFFPNLSSLPNLANIPHLGQLPTVSIPNLPTLAELTTALNNHREHMNFGFKDAVKSRIGEQRERFAGLTANRGINLNLGGALGNMGLRGRPGSKGISQREYEAGQGIEVVGVDDLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9J6</accession>
    <name>A0A1Y1U9J6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cell division control protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_636938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868454.1">
        <property type="nucleotide sequence ID" value="XM_022016956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9J6"/>
    <dbReference type="FunCoup" id="A0A1Y1U9J6">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9J6"/>
    <dbReference type="GeneID" id="33558765"/>
    <dbReference type="InParanoid" id="A0A1Y1U9J6"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="14"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="609" mass="69173" checksum="D0EA74A5D6B1FBF9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9V7</accession>
    <name>A0A1Y1U9V7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_635114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869055.1">
        <property type="nucleotide sequence ID" value="XM_022016786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9V7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9V7"/>
    <dbReference type="GeneID" id="33558595"/>
    <dbReference type="InParanoid" id="A0A1Y1U9V7"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33252" checksum="99BAD99610E98B9C" modified="2017-08-30" version="1">MLSVGLIGSRGFMGSAFLPALTQASHQGKLRLVLLHRPGSDTSSFPENVEKRMIDLAKGDVEDIARSVEGLNVVISAITGRNGGHQLQIPLIDALASSKDLLIFFPSEYATPFRQEDLDRSEFLRRMTCGKAAIIAHAKERKVPVTILKNATVPFLLFSWDGAKFRPKENSLKLYSPRGDGTRGLTSKDFSGAALVHLLLDRPETLPNATISLVEHSFSSQLLVDTFTKIHGRRPDIIETTEEDYQRGIKEDGFGSMGAASDKSLSVGVDWPGETIDSESLSRTGRWDTKSFEDYVRESLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9X0</accession>
    <name>A0A1Y1U9X0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_635176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869065.1">
        <property type="nucleotide sequence ID" value="XM_022016792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9X0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9X0"/>
    <dbReference type="GeneID" id="33558601"/>
    <dbReference type="InParanoid" id="A0A1Y1U9X0"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="659" mass="69208" checksum="7E86AEC3742B986D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Z5</accession>
    <name>A0A1Y1U9Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_635358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869090.1">
        <property type="nucleotide sequence ID" value="XM_022016803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Z5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Z5"/>
    <dbReference type="GeneID" id="33558612"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Z5"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63106" checksum="00AF7FABC168B3C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA70</accession>
    <name>A0A1Y1UA70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869146.1">
        <property type="nucleotide sequence ID" value="XM_022018530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA70"/>
    <dbReference type="FunCoup" id="A0A1Y1UA70">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA70"/>
    <dbReference type="GeneID" id="33560339"/>
    <dbReference type="InParanoid" id="A0A1Y1UA70"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="198" mass="22498" checksum="32DB3D29F7F09C7C" modified="2017-08-30" version="1">MSRPYWVFGYGSLIWKPPPHAIEQKSGYVKGVVRRFAQSSIDHRGTPEAPGRVVTVIQAADWHTLAGTSSDVQDEDFVWGVAYRIDPEKEVEVRAYLEHREQNGYTPHDVKVYSVTDDRETVVVDQAVIWIGQLSNPAFVGYEDPQTVASMIARRSGPSGPNKEYLFNLAHAVRELYPHVKDDYLFDLEARVRALEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAG0</accession>
    <name>A0A1Y1UAG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_158242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868797.1">
        <property type="nucleotide sequence ID" value="XM_022012050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAG0"/>
    <dbReference type="GeneID" id="33553858"/>
    <dbReference type="InParanoid" id="A0A1Y1UAG0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="158" mass="17115" checksum="1E98A860B5BA7FBD" modified="2017-08-30" version="1">MTTVETSPTSRMITSQDLSVGSNKVTVEIRRKEGQQQGDGGGGGGEIEIDADWPFVELTIPEDLPQGYKSALAQFKCGANTQLHVFWTEGDDDKTETELPAFWKDKRYIAYKGLLDEEVQLSDIQTQGFVAPTSTQTAGEDVREATGADSGGAPPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAL4</accession>
    <name>A0A1Y1UAL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_582726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869275.1">
        <property type="nucleotide sequence ID" value="XM_022013577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAL4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAL4"/>
    <dbReference type="GeneID" id="33555385"/>
    <dbReference type="InParanoid" id="A0A1Y1UAL4"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000403">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.125, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="8"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="203" mass="21973" checksum="75C1BC5A158BE9A6" modified="2017-08-30" version="1">MDGLSDEIESILFIAREVMVYQVPPRTSTSGYKAAEWDVEQFMWKGRLRVVEIGNRCELKLEDPSTGELFASATYATPWTQVEPVLDSSRYFVIRVEGDGGQRAYIGMGFQERGEAFDFQVALQSVAKRASAPEPSSDPSQPSKPAAPPKDYSLKDGQTFTIKIPGREGSAKKTPISSTSGPSSGSGGGFGLLPPPPPPGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAM7</accession>
    <name>A0A1Y1UAM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin protein 4, isoform b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_633776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869278.1">
        <property type="nucleotide sequence ID" value="XM_022016660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAM7"/>
    <dbReference type="FunCoup" id="A0A1Y1UAM7">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAM7"/>
    <dbReference type="GeneID" id="33558469"/>
    <dbReference type="InParanoid" id="A0A1Y1UAM7"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="332" mass="37359" checksum="657C3F50BBB22D73" modified="2017-08-30" version="1">MVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGFSLPHAIQRLDLAGRDLTEYLVKLLTERGYLFTTTAEREIVRDIKEKLCYVALDFEQELQTAAQSSQLEKSYELPDGQVITIGNERFRCPEALFQPSFLGLESAGIDETTYNSIIKCDLDIRKDLYGNIVMSGGTTMYNGIADRMQKEITALAPSSMKVKIVSPPERKYSVWIGGSILASLSTFQQMWIAKSEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAV4</accession>
    <name>A0A1Y1UAV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_633989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869348.1">
        <property type="nucleotide sequence ID" value="XM_022016687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAV4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAV4"/>
    <dbReference type="GeneID" id="33558496"/>
    <dbReference type="InParanoid" id="A0A1Y1UAV4"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="244"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="407" mass="46350" checksum="CBC0F3B008A6E71E" modified="2017-08-30" version="1">MSHLIDPNWRASLKPVTGSKFWLDVAGTIMIPYVIFYLSLFGGMRALKLALLPFGYIAAFRVLFLGGLDTQYSAMYGNQMFNLVAGSATRWALSDLPPDYQPTTEPSPFPTIRQSTAYKALSMMLNVHRHVGIKGFIPLRSQGKTRLQYIRHHFIRVIISRQLWTEFVYLVYLFSGATYSAAPATDLYTRMQDFQRHSGIPPAITRTLFAVNIMIMIKLGLEIVWHASAVLMIGSGLWNGEEFPRLINSPLKSTSLTEFWGKRYHQLNRDTLSLWSNLFKPLGRTIQLFSVFLISGVQHYTIYHTGLPIPGSFTAWSSLFLGCGFGIMLERLWYKRTGRHVSGPPGLMWMLLWTALICQPMVCWYWQMIIVDQMPNLTPTHSAVGWILWYTGLAPRPGTLSLHVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB22</accession>
    <name>A0A1Y1UB22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolases family 31-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_652378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869428.1">
        <property type="nucleotide sequence ID" value="XM_022018480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB22"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB22"/>
    <dbReference type="GeneID" id="33560289"/>
    <dbReference type="InParanoid" id="A0A1Y1UB22"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="209"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="522"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="5">
        <location>
            <begin position="637"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="818" mass="92277" checksum="04DFFAFD6D7CC3B1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBC3</accession>
    <name>A0A1Y1UBC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_635142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869059.1">
        <property type="nucleotide sequence ID" value="XM_022016789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBC3"/>
    <dbReference type="FunCoup" id="A0A1Y1UBC3">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBC3"/>
    <dbReference type="GeneID" id="33558598"/>
    <dbReference type="InParanoid" id="A0A1Y1UBC3"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="334" mass="34726" checksum="D6EB386D57106F1A" modified="2017-08-30" version="1">MSEPTVVPSSNPLPTTANGSSTPVFGRGVSGQVGGGAGGAGGTFGVKTGLAQMLKGGVIMDVMNVEQAKIAEEAGAAAVMALERIPANIRRDGGVARMSDPGMIKQIMEAVSIPVMAKVRIGHMVEAQILQSIGVDYIDESEVLTPADDQHHIGKHAFKVPFVCGCKNLGEALRRISEGAAMIRTKGEAGTGDVVEAVRHQRAVMSDIRRAASMSDEELYAFAKELSAPYHLLKETARLKRLPVVSFAAGGVATPADAALMMQLGCDGVFVGSGIFLSGDPAKRARAIVQAVTHYNNPSLLAEVSTDLGEAMVGISVSTEGERMQGGRMAGRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBP5</accession>
    <name>A0A1Y1UBP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869651.1">
        <property type="nucleotide sequence ID" value="XM_022018520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBP5"/>
    <dbReference type="GeneID" id="33560329"/>
    <dbReference type="InParanoid" id="A0A1Y1UBP5"/>
    <dbReference type="OrthoDB" id="3641682at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010991843" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="23121" checksum="5E46D00F0780BE00" modified="2017-08-30" version="1">MLSLIYALIASSSLLANASPINANRTVKLPTYDRHPAAITKREGCGDTRSSNYPIVSMSDQNPGNGDPHQNYWHVQLSESITCSQDAGCQVGQSQTTSITVDWSLASAADITEWFTAGFDVSESWTTGNSYTCDGNAGETVCIWQNVAHTAYSVMEEEINNCVGVTSSHAGVIRSPNSNNQGGGFYCVVGTCGDQGDGYWEAGCAGGPQKNCGNGNVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBS9</accession>
    <name>A0A1Y1UBS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NIPSNAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_633298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869152.1">
        <property type="nucleotide sequence ID" value="XM_022016611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBS9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBS9"/>
    <dbReference type="GeneID" id="33558420"/>
    <dbReference type="InParanoid" id="A0A1Y1UBS9"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="2">
        <location>
            <begin position="210"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="309" mass="34863" checksum="529F30CA2A3D4063" modified="2017-08-30" version="1">MSRRLATQLSRAVQGNKSLRSPNAAFVRTFHASQSSLADKPKPEAPVENEQTGGTGFLGALMYGSKTAKAEGLVANSATQHSKLIGRNKYVHQMVTDLVIPSHRDEYVAAADKYYRAIMNRGDELGGMRLTGSWEAIVGSVGTFNHIIEFDGYKAFDTTIRTLREDKDMAKLQKDILPHIVSREHQMMSEFSFWPSSPPRDSGYPGGGIFEMRSYQLVPGKLLEWEGAWRRGLEARRRFVQPVGAFFSQVGQLHEVHHLWQYPDMETRKSTREKAWSVGGWSDTVRETVRLTKSMKSTILLPCDWSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBW3</accession>
    <name>A0A1Y1UBW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_609331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869695.1">
        <property type="nucleotide sequence ID" value="XM_022014150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBW3"/>
    <dbReference type="GeneID" id="33555958"/>
    <dbReference type="InParanoid" id="A0A1Y1UBW3"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012259930" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46299" checksum="8397838000E20133" modified="2017-08-30" version="1">MISSIKALLLLTASVSAAPAARNLLTPKLVKTPELKGVALDPNLIRDSCISTYELIDGRVLWLCRDTIILKNQSIPYYFEHGQLFGGGAAGLVSSSASWSDQGLLGPDFVQPPPQQGQKDVTSLYPAQLTQYGGSSIYDQDLAYVPYQPDECDGIPAGTSGGNCNDGTRYALWPDSPPVVTNTALDGTVTMHLYLRVPHTGFLRIVDFYPPCSLFKLTYTPNTDKTVLPSISLVAQDFFPRYVFNYGDFAHAKDPLGQTLYLWAQSFQGNYGLARVPVNAVEDLSQYEYYYSNGTGWSSVQPNVNQTEAYVDIGGLGASGQATIYWNPFFGQYVAFGQLEGEFVANLYMSLASNPEGPWSDATLVYSFPTGPSGNGYTLAAHPEMSLLPNEIYISYTGSSDYNNNTNDQVYNTPIYKLTFGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBY5</accession>
    <name>A0A1Y1UBY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chaperone regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_633722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869260.1">
        <property type="nucleotide sequence ID" value="XM_022016649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBY5"/>
    <dbReference type="FunCoup" id="A0A1Y1UBY5">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBY5"/>
    <dbReference type="GeneID" id="33558458"/>
    <dbReference type="InParanoid" id="A0A1Y1UBY5"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666034" description="Chaperone regulator" evidence="7">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40843" checksum="63D6F3A70DE79274" modified="2017-08-30" version="1">MLPSTILSVLSLIFLSGCLAAQSYYQVLGLRKDASEADIKKAYRKLSKKYHPDINPDESAHEKFIEVSKAYEILSEQETRDIYDRHGEEGLKQHEARKQGGSNPNDLFARFFGGGGQQEKRGQGLVLTAEVDLADMYNGRTVEISYPRKIICTHCHGSGAHSDSDISQCKNCGGNGVVVQRHQVFPGMVTNVQMTCQHCGGRGKSITRLCGTCRGQKVIQTDHTIAVHIPAGAPEGFEEVYHGEADESTEWEAGDVVVRVRSRHTEGQGQWSRKDGGLIGRVTLSVAEALLGFKRTLTHLDGRSINIGRAGTTQPGEVEVVEGEGMPAYHDKPQGDMFIEYSVVMPVEVSAESRQKLLDVFGPTSGSVVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBZ3</accession>
    <name>A0A1Y1UBZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_630639</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869725.1">
        <property type="nucleotide sequence ID" value="XM_022016348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBZ3"/>
    <dbReference type="GeneID" id="33558157"/>
    <dbReference type="InParanoid" id="A0A1Y1UBZ3"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="32"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="447" mass="48105" checksum="ECF4B0F0AB77B17B" modified="2017-08-30" version="1">MNQIPLRPLDVTRPSESELEPEDRIVDSDFRAVIICISSFLLIFTTCGTLFSFGVFQDLYQTMSHEPGNPFSGASPAMIDLVGTLGVSFQSVFAPFATAWAKRFSPTAVSSLGGLMFLLGCILASYSTKLWQFILTQGMMLGIGTCLSNMPAVTVAPTWYGPRRGLAMGIILSGTGVGGVAWTPVIQALNQRYGFRMTLRIAGAVTAGMIVLPATLLRWDSASQRRIDQERRNMSLAAKILNIPLLDWQVANSRKFTAQLFSASCQGAAYYTPIFFFSAYARTLGYSATTGASFIAITNACNAIGKIGVGFVADKWGRLNSLFVTTLISTAITFGLWLPSTLDIDVVPSRVLFIAYSIAFGLFASPYVALFPTSLVELFGPAHFASVNGCLYMARGIAALIGTPVAGALIMRDVDSPQAYRSMTIMVGALLAAASGGVLWARIENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC21</accession>
    <name>A0A1Y1UC21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869762.1">
        <property type="nucleotide sequence ID" value="XM_022016368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC21"/>
    <dbReference type="FunCoup" id="A0A1Y1UC21">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC21"/>
    <dbReference type="GeneID" id="33558177"/>
    <dbReference type="InParanoid" id="A0A1Y1UC21"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="454" mass="51346" checksum="06BABEB594D5361E" modified="2017-08-30" version="1">MDDERAEYRIMGFPSLLTGEGGRYSRNEYMWNLCFVFHGSSSLEAFEPVVRKCGRILKSAELDSSYLSSPEPYHTPLSAVLEQLFEDLNSYSETSIPLDGFNSLELKLFPYFPNPPDCSDWHVPIPLVNLDAFRDDNWDITASRVAEHIDGVNHVKRIAELADADIALTRETLRHMLFYQVVMMIDIFQYSNMYTLKPSIARLGSDESVTSECAAYVTRPGYSRQPWPTLLRLYSHLVPGLTIHEWIEKYHTQALGIDPRRFVSFGIIKGFLRRVHRWPVLMEKSTLLSGDGEPRRRVEFDKVPRIESSLSTRSTKLDATARSGGESTFTLRSMESNQSLGVSPSRTPSTLTKSPSRRGHQPNFTNVKDSFPSVHSAGEASIPSKKSGGVMKTGAMKLKERQDKLMEEDLIGMLDGSHHTDEIQVRFGLSWKELDKVIRGSDRGAKDGVVVVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC61</accession>
    <name>A0A1Y1UC61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869794.1">
        <property type="nucleotide sequence ID" value="XM_022018452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC61"/>
    <dbReference type="GeneID" id="33560261"/>
    <dbReference type="InParanoid" id="A0A1Y1UC61"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="466" mass="52700" checksum="29E5578296D0FC53" modified="2017-08-30" version="1">MSKPLHRLEPPPPPSSHHPSASSRLDLERDTEAINHLTLTSQAAWRIIARLRYTTIRWRKDEPLEETPFESPSNQICDFVREVTEVPIDDDSESVITTKLEQFMTCYPNLEDSVSLNHLDQPHWFMEEGRKMKWIVWPRYDYFVEDVAELKALTSSGHNLAVIESIVGEFAQGEVNQPTTKPETTLDSLANVILTSHAASPPDWLPKNIDTAALIGIRCLGISFDWSSASWSAFIPKCGGFLTEMSLALDNGTSSIELDWSAVFHVLDLLDSVSRHSPSLECLELNGFVQAGTFASAFKASTALLKGRLRSLTLNHHHELTTPEQLTLTAHVANLCAPNAFLVMDGRLSDKALRFFHEHSRTDEDYEYFQQFDYTPFEDDPDLISRAAVLPNGRFPAADLKETSEALRRVKVYRDLEWKILQDRRQLAEILGQSRKDREFLVRAGVEVGPIDAEDVSRSEVLAMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC98</accession>
    <name>A0A1Y1UC98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase, V0 complex, subunit E1/e2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_652218</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869834.1">
        <property type="nucleotide sequence ID" value="XM_022018459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC98"/>
    <dbReference type="FunCoup" id="A0A1Y1UC98">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC98"/>
    <dbReference type="GeneID" id="33560268"/>
    <dbReference type="InParanoid" id="A0A1Y1UC98"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="72" mass="8069" checksum="86E2BA0EE1E97D79" modified="2017-08-30" version="1">MAFLHVVFVGLVIAAIAAAAWFLTPRGKNQVLIRSSVTLTLICCYLMWAITYLAQLHPLIAPRKSDLRHAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCA8</accession>
    <name>A0A1Y1UCA8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_631014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869813.1">
        <property type="nucleotide sequence ID" value="XM_022016394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCA8"/>
    <dbReference type="GeneID" id="33558203"/>
    <dbReference type="InParanoid" id="A0A1Y1UCA8"/>
    <dbReference type="OrthoDB" id="2575758at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="429" mass="47056" checksum="CE61E67AE1332C90" modified="2017-08-30" version="1">MSFSTPEPISPVDPSPPCRVRDTPGTEFFSALHLDSPRGMGTKPLRVKKRVARTAGVRARRSTLSLPRTPRSSSGHSTPTRPQRTNTTSTNASRIHHSISQIFLASSPLDLSPPPLPPKHHAYSGVETIAPSPPVSPDTDSPRLPLTPSRAPPKAARLLGTHVKTQIKQKVPRKHHYRPLPTQTLIEIEKFLGNVPPAPPKSSLKPISRAIERKVGHGKTVRHRAMDGTMWMDEEEEQEFASLLGDKETFASVLTSVPPRTTSRPQLARADSAESDTSTGSRRRKAPPPPLKLKPRQINPSLLIISRTPEPSKKVNSHRPKIVDNPFRASQPVQIQSTPETPFVRPRRAPVPLSVYPEEYQIPSDPSPNSVTHSPLDTQISFFDPVTPTSPRPAHRRVLSGSSAAEAAVKSGAWLKKVVGVRRGQLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC7</accession>
    <name>A0A1Y1UCC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative peroxisomal sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_582851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869390.1">
        <property type="nucleotide sequence ID" value="XM_022013585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC7"/>
    <dbReference type="FunCoup" id="A0A1Y1UCC7">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCC7"/>
    <dbReference type="GeneID" id="33555393"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC7"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="447" mass="48996" checksum="24781BA01D5BDF3C" modified="2017-08-30" version="1">MDTSQSSKSRLSRRPLVSDKHARIIIIGGGGTMGSSTALHLARRGYTNIQVLDVWESPSNDSAGNDINKIAGADSIGLFGGVSDEAWEAWVTDPIFRPYAHNVGKLDLTVGSNDRAAHLNKKYEKLRGLGRTDVDWMDSADAIKRKAPHLEQADITGWQGLWCANGGWVAARQALSAVAVECRRLGVKCASGESGTFRTLVLDSSGRCTGVEVADGTIWEGDLIVLAAGAWSPVLVDLEGQCESKAWIYAHIQLTPEESQAWKGIPTMYNDLYGFFMEPQPGTGLLKLCNEFPGYTHMALARPFPLQKDIRMSVPRSHTRHPTDTIPDESREDIKQLIDKCLPHLRGRPLINQGMCWCTDTEDANWLLCEHPKLPGLVLATGDSGHTFKMLPVVGSEVADLIEDKLSDTKRHLWRWRPGAGDPNGTGEGGPRPKDLSDVEGWRSETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCF2</accession>
    <name>A0A1Y1UCF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869392.1">
        <property type="nucleotide sequence ID" value="XM_022018572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCF2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCF2"/>
    <dbReference type="GeneID" id="33560381"/>
    <dbReference type="InParanoid" id="A0A1Y1UCF2"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="382" mass="42761" checksum="DB8CED092A75C42D" modified="2017-08-30" version="1">MGVIPDKKKLTFDDNGKFKVCVFSDMHFGERWGNGSFAAWGPENDNLTNYVHATILDQEQPDYVVFNGDIMTGENVFADNATGYMDQCFRPTVERNLPFSSTHGNHDNADHITHDEEIKYEMAHYSNLSYTRSDVGPAPYGNGNYWVPVYANADDWAPKLIMWFFDSRSFVSGSGDGPGPIPEAADFYWVDPDSVPSYIQQQSLLMKLTWGSVPPSLVFVHIPFEFSETISTLQTPGDHDDEPNPAVQGYAAHQVYTGLDLPTFDAINDCLNEGQNKVMAITSGHDHGESWCARTRTSSGITLCFDGHSGYGGYVTPHSEVRNARIFDLDLNNLNWNPTVETWLSYENKTINTQETLGPNFMATYNQSPDWSANILHSTTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD44</accession>
    <name>A0A1Y1UD44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BAR domain-containing family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_629579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870061.1">
        <property type="nucleotide sequence ID" value="XM_022016228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD44"/>
    <dbReference type="FunCoup" id="A0A1Y1UD44">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD44"/>
    <dbReference type="GeneID" id="33558037"/>
    <dbReference type="InParanoid" id="A0A1Y1UD44"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="304" mass="32700" checksum="D3D41D6230BB75D0" modified="2017-08-30" version="1">MQSWKNFSAQLPAVDMSAMSKNLRNTVQATREKLGNVGPDGITELPAEYKQLEARVDGLRELHQKILKIAKVHETESYDYPSDIAESVQDMGQQAASAWSSFANKNLKNTNLPIPIPAQGAPTPHQPKTLPHAMSRAAKAGATELGSGDRLGMALAVYGSAMEKVGDARMSQDQMISEKFVTPWSATLSTSIGLAMKARANVKTARLELDSARAALKSAAPAKQEQARLHVEEAEDKLVQNTETAIGLMKAVLENPEPIQNLSNLVKAQLIFYSSAAETLSGIQGEIDEAATAAEGEYRTSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDN7</accession>
    <name>A0A1Y1UDN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870280.1">
        <property type="nucleotide sequence ID" value="XM_022016323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDN7"/>
    <dbReference type="GeneID" id="33558132"/>
    <dbReference type="InParanoid" id="A0A1Y1UDN7"/>
    <dbReference type="OrthoDB" id="4584900at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666031" evidence="1">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="297" mass="31818" checksum="978846B1FF18F92E" modified="2017-08-30" version="1">MSTRFWYWVALVQVLLLAVQVQATPFSLAMVERSSHNAVSRTVKQECHTNAECLAAGLPLLKPSPRRMARRGSNTFAATMPIVAVPAGGPAPNASPVKRSSIMERAQKRSYGAPPANSFGYLSAITGNSATASTTTQDITEAIQVSFDTTTSGVQLLEVVGGSVTQYLCMTATEPEIDTEDNTMDLTSFTRTVIAYCDQAGQPNAYPADTSISNSPATWAAESYIWSVDTQSGLLSAYWTNPEGTSPAGIYLQPAFYGDQTSGSIGTYMFTGSYTNYNDQEGGDLSPMDLYVLFPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE72</accession>
    <name>A0A1Y1UE72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_93915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869565.1">
        <property type="nucleotide sequence ID" value="XM_022019283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE72"/>
    <dbReference type="GeneID" id="33561092"/>
    <dbReference type="InParanoid" id="A0A1Y1UE72"/>
    <dbReference type="OrthoDB" id="2592256at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="331" mass="36464" checksum="E8FC9141B4A0FF44" modified="2017-08-30" version="1">MPSKSEEKKAKEKPLFKFGPFEQAIAVLLVMGFANNPSLPYAILSQSHTVFGGMPDGTSTIPLFTPPMIMLVIVAYVGYHVLSRQEALRTRNKALAKAASKSSSSSSSSSSSKKPLSSSDIKSKGLPSSSSRVGDPVPKHVSGGSELDPKKDPSSNLFQQNYFLTMQGPGRPALVPFQDGLRPKAGEAQGTLWWDNVPDDAEQLMAPPVDPANVRSLMKNPYALDMIEKDLELLKLQRQRKEEEERYEKVGGILQTMLGGLLCAVDMRLGVAAIVFFLYRHFTLLQATEHDDLKAAQDDEKKELMKRISEAKKAGADKMELQMLQRQVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEF7</accession>
    <name>A0A1Y1UEF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_629535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870046.1">
        <property type="nucleotide sequence ID" value="XM_022016220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEF7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEF7"/>
    <dbReference type="GeneID" id="33558029"/>
    <dbReference type="InParanoid" id="A0A1Y1UEF7"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="105374" checksum="178B3E8196DCEB3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEP3</accession>
    <name>A0A1Y1UEP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870560.1">
        <property type="nucleotide sequence ID" value="XM_022018377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEP3"/>
    <dbReference type="FunCoup" id="A0A1Y1UEP3">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEP3"/>
    <dbReference type="GeneID" id="33560186"/>
    <dbReference type="InParanoid" id="A0A1Y1UEP3"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="247" mass="27512" checksum="DA0ED503468092C7" modified="2017-08-30" version="1">MNVLDTLFGRSMTPAERLRKHQSSIQKAVRELERERAKLEGQEKKTMMDIKKNAKNGNMNACKILAKDLVRTRHYIQKFTQMRVQLQAVSLRMQTLRSNEQMATAMKGATRAMAQMNRGLNLPQIQRIMNEFEKESSTMDMKEEIMSEAVDDAMEGEEEGEGEDVESDKILKEVFDEIGMNMNDALTSAPTANPLSNEPVANTRIAVAEGLTSSPVASQSGASNGGGGPMSSEEADLQRRLDALRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEU9</accession>
    <name>A0A1Y1UEU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 alpha subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_682369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869759.1">
        <property type="nucleotide sequence ID" value="XM_022019149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEU9"/>
    <dbReference type="FunCoup" id="A0A1Y1UEU9">
        <property type="interactions" value="652"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEU9"/>
    <dbReference type="GeneID" id="33560958"/>
    <dbReference type="InParanoid" id="A0A1Y1UEU9"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="299" mass="33656" checksum="DC85A5BEA377BEEC" modified="2017-08-30" version="1">MRFYEKKYPDQDELVVVQVVSIEEMGAYVKLLEYDNIEGMILLSELSRRRIRSVQKLIRVGRNEVVMVMRLDPDKGYIDLSKRRVSAEEVVKCEEQFEKGKTVNSILSQVAKKVNVDVEELYEKIAWPLHRQYGHSYEAFKVSISEPEVFSSLSISPEILADLKSTIARRLTPKPVKVRADVEVKCFAYSGIEAIRKALKAGESESTEEIKISIRLVAPPLYVMTTTSTEKVIAMDVMEKAVKRIGEVIEQEGGDITIKMAPKIVSESEDAELKALMDKFGAANIQGAGDDDSEDSLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFD8</accession>
    <name>A0A1Y1UFD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870849.1">
        <property type="nucleotide sequence ID" value="XM_022018302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFD8"/>
    <dbReference type="GeneID" id="33560111"/>
    <dbReference type="InParanoid" id="A0A1Y1UFD8"/>
    <dbReference type="OrthoDB" id="2573934at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="144" mass="15763" checksum="8BDE93594EA5E0C3" modified="2017-08-30" version="1">MHKHGVATISHLTSASGTASAKRPTTTVITPYSYATSKIVKTAVAAGVIVLALCGLMLFLKISGWIRYHQRLRRQRYMNTMLLSEQRTNAYEIAAWSDEPGTAPITTGGGTREKSKKEKRGLERAQKRAGVNAHAIHEWEGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFS3</accession>
    <name>A0A1Y1UFS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">BD324DRAFT_580310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFS3"/>
    <dbReference type="FunCoup" id="A0A1Y1UFS3">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFS3"/>
    <dbReference type="InParanoid" id="A0A1Y1UFS3"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="87" mass="9350" checksum="0C716D3DDA3B3C55" modified="2017-08-30" version="1">MAAAATTILPLELVDRCIGSKIWVVMKNEREFTGTLRGFDDYVNMVLSDVKEYEVTSNGVTSTDLGETLLNGNNIAMLVPGGKGPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFY6</accession>
    <name>A0A1Y1UFY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_580331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871007.1">
        <property type="nucleotide sequence ID" value="XM_022013434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFY6"/>
    <dbReference type="GeneID" id="33555242"/>
    <dbReference type="InParanoid" id="A0A1Y1UFY6"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="806" mass="89954" checksum="217EB7A5769C191A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFZ2</accession>
    <name>A0A1Y1UFZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_608887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870968.1">
        <property type="nucleotide sequence ID" value="XM_022014128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFZ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UFZ2">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFZ2"/>
    <dbReference type="GeneID" id="33555936"/>
    <dbReference type="InParanoid" id="A0A1Y1UFZ2"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="469"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="579"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="720"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="815" mass="90143" checksum="AF99B54D47D2436D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG23</accession>
    <name>A0A1Y1UG23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase, alpha subcomplex, subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_629026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870588.1">
        <property type="nucleotide sequence ID" value="XM_022016165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG23"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG23"/>
    <dbReference type="GeneID" id="33557974"/>
    <dbReference type="InParanoid" id="A0A1Y1UG23"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15854" checksum="21085F023EE889F1" modified="2017-08-30" version="1">MTTVPPRFAKVAIQSHTLEHARARTISAYRTWLRSAPEICQIYSLNVPPSMVRLKIRQDFERNRHVENLGVINMLLHKNQQEYQETMNQWKQEPHVEHWFKHYEDPPQPVAFLDKFYAGRDDPSLIEASQRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG49</accession>
    <name>A0A1Y1UG49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NADP-dependent mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_503373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870608.1">
        <property type="nucleotide sequence ID" value="XM_022012953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG49"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG49"/>
    <dbReference type="GeneID" id="33554761"/>
    <dbReference type="InParanoid" id="A0A1Y1UG49"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="258" mass="27874" checksum="ED659C8D4D91BF38" modified="2017-08-30" version="1">MVWQIDLSGKCIVVTGGNRGIGLGISRDCAKAGANVAVIYRQSPSAPQVAEDISKEFGIQCKAYQCDVTDAKAVQTTIDAAIKDLGPLGGVVCNAGMQVSRPALEMTKDDYERQMNGNTWGVFTVAQAAAKIWVEQKYKQGRIVFINSMSATIANDGTTQCFYNASKGALTSLARCLAMEWAEHGILVNSLSPGFVDTDMNQGLRDDPERKKYYEKKVMLGRISDVEEQAGLAIFLLSPYASYITGADYIVDGGVTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG76</accession>
    <name>A0A1Y1UG76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871108.1">
        <property type="nucleotide sequence ID" value="XM_022018189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG76"/>
    <dbReference type="FunCoup" id="A0A1Y1UG76">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UG76"/>
    <dbReference type="GeneID" id="33559998"/>
    <dbReference type="InParanoid" id="A0A1Y1UG76"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="44349" checksum="B6A9020B22D0AFD5" modified="2017-08-30" version="1">MPVPIRQVEHEPEVFPLLTRSEVDATRTSAWYETFEDLTIPSRIIDLETLGEEEAFRDWLNGDSIFLPQDSENVSSISSSSFDATGSNSDSAPVYHLPKLNTAIRTAIQAFGGSVFPKLNWTAPRDAAFIIPQTEGGPLYCKTPADVYLVLKSSDFISHGLDYARAYASGSSDLVEYAVEDQQNETEEVPVEIVLKKYIQMIPSREWRCFVRDDVLLGVSQRDTNFYDFLQDSDAKRQVIDAIRDFWEDEVRLNFTTGGGSYIFDVYLSADMTRVTLIDFNPYRNSTDPLLFTYEELLSILLAHRRRSRQSSPLPYGLAELSSDAAGLHVRLPILKIVESASDPEANRTTPAFAGNMMPLDVMALSQGRNMGEFKDAWEEALARGMDDVSSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG95</accession>
    <name>A0A1Y1UG95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_579856</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871129.1">
        <property type="nucleotide sequence ID" value="XM_022013412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG95"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG95"/>
    <dbReference type="GeneID" id="33555220"/>
    <dbReference type="InParanoid" id="A0A1Y1UG95"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="159"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="803" mass="91314" checksum="B3E0BB8068B8A252" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGF7</accession>
    <name>A0A1Y1UGF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_624856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871150.1">
        <property type="nucleotide sequence ID" value="XM_022015740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGF7"/>
    <dbReference type="FunCoup" id="A0A1Y1UGF7">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGF7"/>
    <dbReference type="GeneID" id="33557549"/>
    <dbReference type="InParanoid" id="A0A1Y1UGF7"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="173" mass="18550" checksum="9D0547238747D5B4" modified="2017-08-30" version="1">MFGAALRPLLTPSSNLYRTAVRNNLVKPTCLPVAQRFTSVRFASSGPRFSDDHEWITVDENNIGTVGITDYAQKALGDVVYVEVAAPGDTLEQGGFMGSVESVKAASDIYSPVSGTLASVNEALKDQPSLLNKDPMGKGWVCKIQLSDPAQVETLMDDAGYKAFCESDPGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGR8</accession>
    <name>A0A1Y1UGR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_580751</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870366.1">
        <property type="nucleotide sequence ID" value="XM_022013458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGR8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGR8"/>
    <dbReference type="GeneID" id="33555266"/>
    <dbReference type="InParanoid" id="A0A1Y1UGR8"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="159"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="591" mass="64737" checksum="056D4265458256FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGU9</accession>
    <name>A0A1Y1UGU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_579508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871329.1">
        <property type="nucleotide sequence ID" value="XM_022013384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGU9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGU9"/>
    <dbReference type="GeneID" id="33555192"/>
    <dbReference type="InParanoid" id="A0A1Y1UGU9"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="118"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="620" mass="67961" checksum="818CD079641EAFD6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGW4</accession>
    <name>A0A1Y1UGW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_642336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870813.1">
        <property type="nucleotide sequence ID" value="XM_022017478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGW4"/>
    <dbReference type="FunCoup" id="A0A1Y1UGW4">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGW4"/>
    <dbReference type="GeneID" id="33559287"/>
    <dbReference type="InParanoid" id="A0A1Y1UGW4"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="418"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="763" mass="85803" checksum="B65D7F19CDCAA147" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH77</accession>
    <name>A0A1Y1UH77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YABBY protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871377.1">
        <property type="nucleotide sequence ID" value="XM_022015832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH77"/>
    <dbReference type="GeneID" id="33557641"/>
    <dbReference type="InParanoid" id="A0A1Y1UH77"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056775">
        <property type="entry name" value="YABBY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04690">
        <property type="entry name" value="YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YABBY protein C-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="66" mass="7272" checksum="20BC9980655623A3" modified="2017-08-30" version="1">MPPKKTAAGKTGGKAKPSAYNEFMKVQLAKLKAEQEKSGKKADHKTNFKTVAQMWAKAPENPKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI55</accession>
    <name>A0A1Y1UI55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">10 TM acyl transferase domain found in Cas1p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_625303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871255.1">
        <property type="nucleotide sequence ID" value="XM_022015783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI55"/>
    <dbReference type="GeneID" id="33557592"/>
    <dbReference type="InParanoid" id="A0A1Y1UI55"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="10">
        <location>
            <begin position="418"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="819"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="918" mass="102904" checksum="A40B8EE70371AFDE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UID5</accession>
    <name>A0A1Y1UID5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_680636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871736.1">
        <property type="nucleotide sequence ID" value="XM_022019086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UID5"/>
    <dbReference type="GeneID" id="33560895"/>
    <dbReference type="InParanoid" id="A0A1Y1UID5"/>
    <dbReference type="OrthoDB" id="2930561at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="307" mass="34759" checksum="4B64F60080257012" modified="2017-08-30" version="1">MSLPASQEAGRAGRAARRAREEPQAKFSMEDDRVIGEMLVEERSRGAQGGFKRQTWTRIAQELNDRFHPDVPKTARSCQDHFSYVKNSYLIVAEDDIWDKYLAAHPKARKWRRDRWELYLLYKEATGNFRARGQHVYRPGDTQEGSDGEDDGGVDEDQYDSAMENTINELTGTQPLSQAAQDVVDIFSQLSGTPDPSRSLRTPPPLNGRRKASDALGDGLRELAGSIRHWAESSSNRERQLMAIRVEALKKLQKYEELSVVKKGRVMMKLSTDMEACKSLLSFEEAQVDPEAVLVILRGWSELQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UID6</accession>
    <name>A0A1Y1UID6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GRASP55/65 PDZ-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_623268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871759.1">
        <property type="nucleotide sequence ID" value="XM_022015562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UID6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UID6"/>
    <dbReference type="GeneID" id="33557371"/>
    <dbReference type="InParanoid" id="A0A1Y1UID6"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="251" mass="27275" checksum="39272116A5FA8C9C" modified="2017-08-30" version="1">MGQSSSALPSSLPENALHCLRVADGSPASGLLEPFFDYLVDVQVDNAASSSSSISPLPRIDARHLGQLLEDNEGKRITLKVYNAKSQRLRDVSLTPNRNWFQGVTEESGPRPSLLGVSLRQCNPANALESVYHVLDVLEGSPAEMAGLVPWGDYVLAWSGGPLHSENDFYRLVESHIDKPLRLFVYNADLDNLREVILYPTRQWGGEGLIGCGIGYGLLHRIPRPSTPPTTVFNADSSFSPVASPPLVNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UII9</accession>
    <name>A0A1Y1UII9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_579970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870984.1">
        <property type="nucleotide sequence ID" value="XM_022013420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UII9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UII9"/>
    <dbReference type="GeneID" id="33555228"/>
    <dbReference type="InParanoid" id="A0A1Y1UII9"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="76"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="546" mass="59516" checksum="1DB13759875CA7ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJJ6</accession>
    <name>A0A1Y1UJJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_607790</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872145.1">
        <property type="nucleotide sequence ID" value="XM_022014083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJJ6"/>
    <dbReference type="FunCoup" id="A0A1Y1UJJ6">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJJ6"/>
    <dbReference type="GeneID" id="33555891"/>
    <dbReference type="InParanoid" id="A0A1Y1UJJ6"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="434"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX38223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="865" mass="97427" checksum="D7B7CEDB8BFB1D74" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJL1</accession>
    <name>A0A1Y1UJL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_589570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871714.1">
        <property type="nucleotide sequence ID" value="XM_022013780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJL1"/>
    <dbReference type="FunCoup" id="A0A1Y1UJL1">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJL1"/>
    <dbReference type="GeneID" id="33555588"/>
    <dbReference type="InParanoid" id="A0A1Y1UJL1"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="77"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="51544" checksum="9D71CE69D2AB8213" modified="2017-08-30" version="1">MLRTRIPASVTSALRSAERSRLPVRQLAGPSQHASRSLSTVAARGRTRSARSAMIPTPAWSARSYAAEAGNKFTRAKPHFNIGTIGHVDHGKTTLTAAITKLMSETGGGKFLDYNEIDKAPEEKARGITISTAHVEYETQNRHYAHIDCPGHADYIKNMITGAAQLDGAIIVVSATDGQMPQTREHLLLARQVGIKKLVVFINKVDQVDDPEMLELVDMEMRELLSQYDFDGENTPIVMGTALAALEGRDPERGAKKIAELMEKCDTWLDMPERDLDKPFLMSIEDVFSISGRGTVATGKVERGTITKGSEVEIVGFESGFKTVLTGIEMFHKELDRGEAGDNMGALLRGVKRDQIRRGMVLVVPNSIKAVKRFKAQIYVLTKDEGGRYTPFVANYRPQLFMRTVDVTCQLDWPEGTEDARDKLVMPGDNVEMIGNLVHDVALEPGTRFTLREGGKTIGTGIVSEIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJN5</accession>
    <name>A0A1Y1UJN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eisosome component PIL1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_680012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872180.1">
        <property type="nucleotide sequence ID" value="XM_022019062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJN5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJN5"/>
    <dbReference type="GeneID" id="33560871"/>
    <dbReference type="InParanoid" id="A0A1Y1UJN5"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF6">
        <property type="entry name" value="EISOSOME COMPONENT PIL1-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="802" mass="84485" checksum="D269E1EBA764FB2D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJR2</accession>
    <name>A0A1Y1UJR2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872213.1">
        <property type="nucleotide sequence ID" value="XM_022015267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJR2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJR2"/>
    <dbReference type="GeneID" id="33557075"/>
    <dbReference type="InParanoid" id="A0A1Y1UJR2"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="619" mass="65423" checksum="E0C9C92753272702" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJS4</accession>
    <name>A0A1Y1UJS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018131.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UJS4"/>
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    <dbReference type="OrthoDB" id="2575837at2759"/>
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            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="653"/>
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            <end position="385"/>
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            <end position="464"/>
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            <end position="474"/>
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            <begin position="475"/>
            <end position="494"/>
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            <begin position="536"/>
            <end position="549"/>
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            <begin position="575"/>
            <end position="588"/>
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            <begin position="620"/>
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    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="ORX37787.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
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                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
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                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
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    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX38403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022015316.1"/>
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    <dbReference type="STRING" id="4999.A0A1Y1UK19"/>
    <dbReference type="GeneID" id="33557124"/>
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    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
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        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
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            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKG6</accession>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
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                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
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                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
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                <person name="Lindquist E."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022014105.1"/>
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    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="TM41A/B"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="324"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="417"/>
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        <location>
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        </location>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="633" mass="67614" checksum="9939E3B053B10908" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKZ5</accession>
    <name>A0A1Y1UKZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter type 1, transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_577952</name>
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    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872139.1">
        <property type="nucleotide sequence ID" value="XM_022013287.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKZ5"/>
    <dbReference type="GeneID" id="33555095"/>
    <dbReference type="InParanoid" id="A0A1Y1UKZ5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1165"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="359"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="691"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1041"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1367"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="939"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1487"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1686" mass="187333" checksum="02A2ABBB201F0D12" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULB4</accession>
    <name>A0A1Y1ULB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_617506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872701.1">
        <property type="nucleotide sequence ID" value="XM_022014928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULB4"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULB4"/>
    <dbReference type="GeneID" id="33556736"/>
    <dbReference type="InParanoid" id="A0A1Y1ULB4"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF659">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="42414" checksum="79C262433C533C27" modified="2017-08-30" version="1">MSSRHSPQPKRQASIACIALVVMTGIIFLFGHPEAPSNICSSFDRDYLVGVGKYGGTRTDRLKAYKAQFPALRPLTDRGRPTAPSPSGSKDHQITPFDWPTIKTLFAFGDSFTTNYQYRMYQEWQDRGDGTFDPAVHLNNRKTDRIWTDWLWSTFTDTSKTKYYNLARPGATISREVLPPGQEEWGTLEDQLADFEQIFSRGSGQSNNNNNDDWQSNSTLFLMFFGINDISQLDRRTAFDSPIQQTCGQFAHALFEQSSKLYDMGARHFVFLNAHPFYRSPKYTLEGGVGHDVYGRVVDSVTWFNEAYGDEIELFRQRHPQANVISFDLFRYIDLIMDEPELFGMTETERFHMTIDDTGDETNHGRLGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULG9</accession>
    <name>A0A1Y1ULG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPI inositol-deacylase transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_617810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872756.1">
        <property type="nucleotide sequence ID" value="XM_022014947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULG9"/>
    <dbReference type="GeneID" id="33556755"/>
    <dbReference type="InParanoid" id="A0A1Y1ULG9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="2">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="104" mass="12053" checksum="C6C06A1D8F180DE6" modified="2017-08-30" version="1">MLLLTFILPFNLVTLGIWARTLWLDWRSAFSSDHNILRVIPLLGLVELSSRTQELHSRHLFIRVAQACLLLLSLIAFLFGGRHMYILPYLVDPVLLCLWGILWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULJ2</accession>
    <name>A0A1Y1ULJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_294093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872715.1">
        <property type="nucleotide sequence ID" value="XM_022012400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULJ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULJ2"/>
    <dbReference type="GeneID" id="33554208"/>
    <dbReference type="InParanoid" id="A0A1Y1ULJ2"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="432" mass="47794" checksum="AD8D8B16D140C4EB" modified="2017-08-30" version="1">MGKTFPTIEKLETFIPSAHGSGGDYHRQAAEHWIVAGNISCPMHKYPEYRHSRTSWGIGVLGSIFVKLTATDGTVGYATGFGGPPACWLIEEHFKRFVIGQDPRDTNKIWDQMFRASMFYGRKGLPLAALSVVDLAIWDLLGKIRGEPVYKMIGGRTKKDIPLYLTGPKPPVAKKLGFWGSKVPLPHGPPDGHEGIRKNVEFLKKCKESVGEDYPVQVDCYMSLDVPYTIALVKACEKAGVEINWWEEVLHPDDFDGHVKLKEALPHVKFTTGEHEYSKYGFRKLIENRAIDILQPDVMWLGGLTELIKVASMAAAYDIPVVPHGSGPYSFHAIMSFPNSDFCEYIANSADGESIAPSFGNLFTNEVLPHNGRVDLTDEPGFGLELNPHAELVPYSSFFLPARGIGAADEELKSEKKLPNGAQPATVEELTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULR8</accession>
    <name>A0A1Y1ULR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_641280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872854.1">
        <property type="nucleotide sequence ID" value="XM_022017413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULR8"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULR8"/>
    <dbReference type="GeneID" id="33559222"/>
    <dbReference type="InParanoid" id="A0A1Y1ULR8"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="16"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="506" mass="55392" checksum="7710CD477BB8A6C0" modified="2017-08-30" version="1">MIALAGMVSRLSVVQIGTGLFLSTGSALASAGPLGLLLAYILMGAVTACIAYISAELSAFIPLSGGFIRHTALYIDKSTAMVVGWDFAYTMAVTMPAEITAATNLIGFWNPKITPAMGITIFWAGIVFINFCPVRWYGESEYFFALLKIALIVGLILGGLILDLGGVKGQERIGFRYWKAPYEPIIAQFTTGAAGRFLSFWNVMISAAFAYNNVQVVATAGAETRDPRRSIPRAVKTTFWRVAIFYIISVLIMGMIVPANALDLVDKSGTAASPFVIAFDRAGVKVLPSIINAVILTSAFSSGNSCTFLASRTMYGLALDGFAPSVFLRVSRWGVPYVCVFVSSLFGSLAYLSLGATAMQAFGWLVNIVTTAGLIAWCVICITFIRFERGMRIQGISRTRLPYKAPLQPYLTWFASIVITLILLFCGFSAFTPTFSYSAFLTNYLNVLIFIPAWIIVKLVRRDRPIAYADMDLEGPLRTWEEEKDLNADSIYGRLSTWEKLLNKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM74</accession>
    <name>A0A1Y1UM74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_578003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872549.1">
        <property type="nucleotide sequence ID" value="XM_022013291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM74"/>
    <dbReference type="FunCoup" id="A0A1Y1UM74">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM74"/>
    <dbReference type="GeneID" id="33555099"/>
    <dbReference type="InParanoid" id="A0A1Y1UM74"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="36903" checksum="B467D488A9EEE123" modified="2017-08-30" version="1">MTSNSNGESHLAIDCHKLDFSWNQDSELVLEGVDLNLGKGSRCLLIGANGAGKSTLLRILAGKRLTKTRACKILGQDVFMNPPNGVVYLGTEWSTNPVVRSDIVVSEFLDSVGGYRHKERRDRLLSILDVDLDWHMHQISDGERRRVQLCMGLMTEWDVLLLDEVTVDLDVLVRSDLINFLIQETETRGATIVYATHIFDGLSSFPTHICHLQLGRTPRPLHVWEATSGVEDLFKLALQWTREDRDLRRIKEKETGRVRGPKKADEVSVLQRFAAASFDSSPTSSYVRWHRCLLSSKRRKTPKCSSKSTTTRTDGEYSIVSFSDVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM85</accession>
    <name>A0A1Y1UM85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_618706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873031.1">
        <property type="nucleotide sequence ID" value="XM_022015071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM85"/>
    <dbReference type="FunCoup" id="A0A1Y1UM85">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM85"/>
    <dbReference type="GeneID" id="33556879"/>
    <dbReference type="InParanoid" id="A0A1Y1UM85"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="26069" checksum="457AB8E62D92B488" modified="2017-08-30" version="1">MSSLKHLKVSPKEAHTATIIFLHGLGDSGQGWLPVAKALWSNFPGLKWILPHAPLQPVTINQGMRMPSWFDLSTLDKLTDSKYDDERGLLASIASVDALIQAEVDAGIPESKIFLGGFSQGGAVAMYSGLTGKRRLGGLLALSTWIPLNHKVPQTLTTHSRDIPIFWGHGKDDPVVAYEFGERSVDLLTRQLGFPRVPAGSIFARPGLRFQTYEHIGHGTNQREIEDIKLWLEAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMR2</accession>
    <name>A0A1Y1UMR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_326236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873204.1">
        <property type="nucleotide sequence ID" value="XM_022012490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMR2"/>
    <dbReference type="GeneID" id="33554298"/>
    <dbReference type="InParanoid" id="A0A1Y1UMR2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="444" mass="50020" checksum="55DE8FBB0A82239E" modified="2017-08-30" version="1">MIVVILLPYLYSTLPNLPTIAKVARGDTSFGIWWGAYCMEREPWWRIVRAISLMIPALITFVLCVIMILSLWSCHGDPSPRVRVRRMECLQVAYWFLCALGLLVYSVFEQTNGWNFDWSPRVAENAIGPIVWLAFASNANIWRAYSHWLRLRRPPKPECLLIDDIETASFSKWLSPGSGRLATSVHSSRSSFYIPPPHPQPHLRAEQRRTWSPFSRKPSSRVARSRGIHDSETKRQQSLQADEKLQQNPFVGSSVPRSPPFAFSEEVSDQDELSPQALSPTINFTGEREPSGNLHELSRLPPPSQATLKDPIKKRVSSPSILSYNLPRPYLRGRRAGLVNRPPNIETGHPRSTSPAPLSSGLSSSFHLHIPKTAYTRPRSAGSTGFSAVSLYSTCSSTTPQVDTETPEEQLYKVPASPPGSELVVGKLYDRNAMRIWRQKRARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMT0</accession>
    <name>A0A1Y1UMT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_327602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873226.1">
        <property type="nucleotide sequence ID" value="XM_022012500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMT0"/>
    <dbReference type="FunCoup" id="A0A1Y1UMT0">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMT0"/>
    <dbReference type="GeneID" id="33554308"/>
    <dbReference type="InParanoid" id="A0A1Y1UMT0"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="168" mass="18419" checksum="1C9F7A0AF663771A" modified="2017-08-30" version="1">MRNMSVCGMKLGTKGTKRINGARAHELSMEGKEHARKQDEIDEQAANWIYYANNTDSPPGTIDLHGLYVQEAIQRTEAAITQAQQNGQEEINIIVGKGIHSQGHVAKIKPAVEDLMRKYNLSAHLDPHNSGVLIVDLQGRQMNGRGTRDAGGLVDEMSQKGGDDCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMX6</accession>
    <name>A0A1Y1UMX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_577392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872730.1">
        <property type="nucleotide sequence ID" value="XM_022013254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMX6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMX6"/>
    <dbReference type="GeneID" id="33555062"/>
    <dbReference type="InParanoid" id="A0A1Y1UMX6"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="9">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="217" mass="24188" checksum="0BEB39D130500AC6" modified="2017-08-30" version="1">MEEDDDWLNDESGQSYRHQGGAADPLVDAEWNRLATRYSDAGYREGITDGKLATLQQGFDQGFNSSVLASRRLGQLRGRANGLLSFLLKTDIPAQNGSSSADPARVDLTISNVREFVRLLGNVKRDDILPLDTERLEHERNEHPDQDHAFEFERNDKRDMEGLEDAMRAVSSGGDIVGPRPETRKENTDSARDASSLDALERQLIQLEAAIIGDHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNQ6</accession>
    <name>A0A1Y1UNQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873463.1">
        <property type="nucleotide sequence ID" value="XM_022017820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNQ6"/>
    <dbReference type="GeneID" id="33559629"/>
    <dbReference type="InParanoid" id="A0A1Y1UNQ6"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="490" mass="53284" checksum="54A51BA7CE5391C4" modified="2017-08-30" version="1">MITDDTGQHLQTLPDDVLSHLLRYLDLEELLRLQQVNRQLRERVITLGLPQYLVRHAQNHVTLCPQQDSWKPYDLVRRNLTILQNLKARQWHALQIGPTWQSPVIPTLTLTPSMLLLGVGGKLLVHPLHDWPTSGGKVVGRAKEHLIASKGTGSGADIIGVAPLVDDGSAFTVAQFDGTLQTYTYENSGLRPGTRWRHADGANVHTLSASSKGDLMLTSTSAGVVSIFSPTSPRGPLEAFSLPTSARAWSSLVATSHASLDPSIMVGVHGGILIYPMSPTGVVNTPRKLLGPDKPSRSSPYCLTFPSKPSVHHPSLLLSAWYDSHLRIHDLRSPDISPQMEFADPWQWADASAMYCATYFAENHIAGGGSRHGTVSLFDIRQPKAGWSIFTPGGKGSPVYALQGEGGRLWGVTERRAFALSFDGSGGIPAGLVASNARAPRTDVRHTPSGWKGRGGKWRWTVRYNESADVCTGYNHSERGVNLFESLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP31</accession>
    <name>A0A1Y1UP31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873089.1">
        <property type="nucleotide sequence ID" value="XM_022017970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP31"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP31"/>
    <dbReference type="GeneID" id="33559779"/>
    <dbReference type="InParanoid" id="A0A1Y1UP31"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="30423" checksum="80301A474305E529" modified="2017-08-30" version="1">MVFSPLPAQLVVKPGFARERFESTGVVLVPGLLQHDEIEKIKKTFTEHVEHYTDLNFDDHIEKDDILSRYPRFVHPHRHPETAPGEIARRMIIDKRILQIVKELFDGGEAYGAQSMFYFKPPTARGQAMHQDNRSLQAHPETCLACWIAIDDADGENGGLLVIPGTHRSEILCHDEDAPADTFDRRQIKLPPGLTPIQTELRAGDALFFNGSLVHGSRGNTTTDRFRRALIFHYVPQTATQIKPFYHPLMTPDGKEVTIEESPEGGPCGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP34</accession>
    <name>A0A1Y1UP34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAP Gly-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_615068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873593.1">
        <property type="nucleotide sequence ID" value="XM_022014677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP34"/>
    <dbReference type="FunCoup" id="A0A1Y1UP34">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP34"/>
    <dbReference type="GeneID" id="33556485"/>
    <dbReference type="InParanoid" id="A0A1Y1UP34"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="25921" checksum="F45A2FB1EE7DF67B" modified="2017-08-30" version="1">MPLINIFVSSPDTYSERRFESSLVVSELQEKLYSITGISPQFQRLSVSHSSSAGQPQSLDDQNRSLDSYGVKDGYHLKVDNLDPNARPGEFSDVSGVNKFELSNEEYESRPDTVLAHLKANKMGRFAPVPENLSHPPPPSHALPENVSVGSRCQVAGEGGNMDRIGTVRFVGIAEIGKGGVWIGVELDEPVGKGDGEVEGKRYFSCSPKHAIFVRPEKITTGDFPEEDLMADDVDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPB8</accession>
    <name>A0A1Y1UPB8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BNR repeat-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_302019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872838.1">
        <property type="nucleotide sequence ID" value="XM_022012429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPB8"/>
    <dbReference type="GeneID" id="33554237"/>
    <dbReference type="InParanoid" id="A0A1Y1UPB8"/>
    <dbReference type="OrthoDB" id="504663at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43752">
        <property type="entry name" value="BNR/ASP-BOX REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43752:SF2">
        <property type="entry name" value="BNR_ASP-BOX REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="391" mass="42866" checksum="E43C8E7299F72309" modified="2017-08-30" version="1">MTDQQPTIPPFAEVPKTATSGKITAEFVTKDDARAPSVHCSTIAVAGGIRYLAWFGGSGEGKPDVKIWFSKYVNGNWTDQVSVAGDGTLPHWNPVLFIPDPVNEPKHVYLFFRTGKLISSWITYIIESTDGGDSWSEPKELVQGDRSGGRGPQKNAPIVLSNGDWCTGASYEVPNPDPSKPYGVWDSYSDFAPKPKEGDTFKQGDVWIKSPLVELPADRGVPGGSFPGEGAIQPGLWESKDAPGHVHLTLRSSAGCILRSDSEDYGRTWTPAYRTILPNNNSGHDIARLKDGRVIWTGNYNTRNWGPRTPLCLMISQDDGQTWKLWATVEQAPPPHDEIRLTGADAGGVDGLEEYSYPSIVPLEDDDGEVGVWMSWTWQRRGIKVAKIVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPG3</accession>
    <name>A0A1Y1UPG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_305012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872888.1">
        <property type="nucleotide sequence ID" value="XM_022012439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPG3"/>
    <dbReference type="GeneID" id="33554247"/>
    <dbReference type="InParanoid" id="A0A1Y1UPG3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="179" mass="20117" checksum="0D08AD3BD74908F2" modified="2017-08-30" version="1">MRHGEGVCENTEEVVNASQVGGSETVVSGGICGVQGRGRDSLVYIYMCVFTGGKQWALGVSRVPKRWRFRLSNLPLLLRLWVQTESTPPLNQSSGRVSSFAPSLWVLICDDDVSQANLLLRPGGFQRWRRGIHRQSLEIWCDHGVGQLWRREVEKGGVVPRRLVGRQPKLDQAEHSPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPR0</accession>
    <name>A0A1Y1UPR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF885 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_251630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873825.1">
        <property type="nucleotide sequence ID" value="XM_022012289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPR0"/>
    <dbReference type="GeneID" id="33554097"/>
    <dbReference type="InParanoid" id="A0A1Y1UPR0"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="71428" checksum="0C691262EC9A2C39" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ89</accession>
    <name>A0A1Y1UQ89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_267264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874013.1">
        <property type="nucleotide sequence ID" value="XM_022012330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ89"/>
    <dbReference type="GeneID" id="33554138"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ89"/>
    <dbReference type="OrthoDB" id="2568780at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118726" description="Calpain catalytic domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="166"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="444" mass="47231" checksum="B683AB5B3217A1FF" modified="2017-08-30" version="1">MLGFITWRLCPLILLLTLCSASAKPRRVATRIPKRPPPRRLVEHDPKWDHRWIKRDAPVVWATSTHDSSTVSYAISSAISRGPSSVHVSGGGSVFSSAGSGSPASFVNALDGQSASASASASGGSSADPSTSTGPLVSASLSTSAASSGISSGISASTSGSASQSQSLSSSLPSASASASASASSAANSSQLSGEGWHFPYTALWNGTAPNLEDVKQVRLANCWQPATSIALVYIAPEWVSHLITYSDGEPMAGESDPSNLYASVTLWNPNNGWSYQFPVNIYNESTTEDFPGGVWWHSALSQGLAGMAQMTPIVGMNSDGTYTQTNGSPAYALAMMTGRKVDYYTFDDYPSVDDFYEALSKASSTPVILATKYTTDPSVDPPLTANHDYAILSTSDKGAQGRYVNVRNPWGKYETFHVEAIYYNFSYLYMMEDQSELIWQGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQB9</accession>
    <name>A0A1Y1UQB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_616956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874008.1">
        <property type="nucleotide sequence ID" value="XM_022014867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQB9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQB9"/>
    <dbReference type="GeneID" id="33556675"/>
    <dbReference type="InParanoid" id="A0A1Y1UQB9"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="169" mass="18805" checksum="831A564A4A4E07B5" modified="2017-08-30" version="1">MAFDTTVRRGHPILFGLILLFSLIEGCDTAYIVGQYNSADNYPNHSIRDRSRFLVFTSWWTVVFSALYLAFYLTGIFEIFTSIASHGVWLFITWVFWLAGAAAWSAALSGGVYCGVPGEIGHYHCHQLLAAEAFAWITWILMTFALIVVILLGSRALRSGNRLSGGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQL0</accession>
    <name>A0A1Y1UQL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_615223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873632.1">
        <property type="nucleotide sequence ID" value="XM_022014696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQL0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQL0"/>
    <dbReference type="GeneID" id="33556504"/>
    <dbReference type="InParanoid" id="A0A1Y1UQL0"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="398" mass="44678" checksum="009765E04AAC4465" modified="2017-08-30" version="1">MCRFIVYKGHEPIQLSHLVTRPRHSITNQAFESKLRFPSSRPMNADGFGIGWYDPLQTPCQEKDPYPETTSPKSPSENPSLSNGVAQRAEASSPMHPTGSSGVFEGDDADAQQLLADRAKERELENERPCIFKSISPAWSNANLERLAEKIRSPLIFAHVRASTMPGAPSEDNCHPWLFGKLMWMHNGEISGFTKIKRALQSSLPEELFLYPAGYTDSEWAFMLFLSKLKDPHARFFTHVELRDAMMETIKTLNMLLKDAEVTSPSLLNFVVSDGHTVVATRYISSRTSEASSLFFSSGTSFDEIQDGGMYRMTKADKRESIILIASEPLTFERSDWMEVKTNTMLVITPKMNLLQIPIIDEFWVAPQDPASQHRTTDFAISMGFGHGFAASKEQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQU2</accession>
    <name>A0A1Y1UQU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regulation of translational elongation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_648464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873629.1">
        <property type="nucleotide sequence ID" value="XM_022017844.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UQU2">
        <property type="interactions" value="776"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQU2"/>
    <dbReference type="GeneID" id="33559653"/>
    <dbReference type="InParanoid" id="A0A1Y1UQU2"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1411"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1580"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1699"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1721"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="2044"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2586" mass="280324" checksum="895BE82830716100" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR44</accession>
    <name>A0A1Y1UR44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_6254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874210.1">
        <property type="nucleotide sequence ID" value="XM_022015797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR44"/>
    <dbReference type="FunCoup" id="A0A1Y1UR44">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR44"/>
    <dbReference type="GeneID" id="33557606"/>
    <dbReference type="InParanoid" id="A0A1Y1UR44"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="34558" checksum="2A6D0C51FD64A6AA" modified="2017-08-30" version="1">MSEQPGFLSAARYGKDLVKVCRVVREDEKHHVVEYVVKVMLEGDIETSYTKADNASVVATDTMKNTVNVFAKTSRHVLDPTLFALHLALHFVTKYAHIHKAFIDVTSLRWSRIEVNGQPHKWSFVRDGDEKQTSEVAVDATAGKDHLKASVKAGLKDLLVLKTGGSAFEKFHRDEFTTLAEVKDRLFSTMVALSYTVDLPPNVSLSIDNLPEIGKDIGFTKIAQLVRQNTLEVFAEDESASVQATMYNTAQKVLSSCPAISEISYSYPNKHYIPVNLSAFGLENGLGYEGGAEVFHPTADPSGLITATVSRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URS5</accession>
    <name>A0A1Y1URS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873640.1">
        <property type="nucleotide sequence ID" value="XM_022014701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URS5"/>
    <dbReference type="GeneID" id="33556509"/>
    <dbReference type="InParanoid" id="A0A1Y1URS5"/>
    <dbReference type="OrthoDB" id="2589196at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="140" mass="15761" checksum="AEEE83526B32DCE5" modified="2017-08-30" version="1">MILWAIGIIPVFFTTLAILPLLFVHESRALRFVGNRVFFIFSANLAMIVVVTAWLLSIYGWSIAHRTFEVVPLEVHLGSAIWMGLTAAICLIIVYLCNWPKDAWDGYATKASGGRGRGLPTPGNGYYHYKRSTREVVPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US44</accession>
    <name>A0A1Y1US44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_24324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874532.1">
        <property type="nucleotide sequence ID" value="XM_022012260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US44"/>
    <dbReference type="GeneID" id="33554068"/>
    <dbReference type="InParanoid" id="A0A1Y1US44"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="23157" checksum="ABF6CC23AC8DBC96" modified="2017-08-30" version="1">MDIFLPHIFHLLRLINKDQATPPAQKPELKMIRLTTLCALALALYGQSAQGLTFSRKLSRDSGAAANPLPGGTALKQASRAGIVKRQQQLARSDRLRPRTSGASTSPSYDYCPGFSSGPPKPHAVYMNVGAPTEGAYDDTVVSSLSDCIAYVDTTYGTQFFGAFNSAENPATCYVYEGSPGTSDYTSTGSFTLFAQKSCADNAINAGSSTTCCNAPTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US81</accession>
    <name>A0A1Y1US81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_612430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874559.1">
        <property type="nucleotide sequence ID" value="XM_022014389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US81"/>
    <dbReference type="GeneID" id="33556197"/>
    <dbReference type="InParanoid" id="A0A1Y1US81"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="63" mass="6804" checksum="100BD21CFA1B95D7" modified="2017-08-30" version="1">MNTCCALSAARAPSCHSHMRAPPLQKGREKRASASPMLSKNALSQVPPDRSILIFIAHCTWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US86</accession>
    <name>A0A1Y1US86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_648899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874101.1">
        <property type="nucleotide sequence ID" value="XM_022017903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US86"/>
    <dbReference type="STRING" id="4999.A0A1Y1US86"/>
    <dbReference type="GeneID" id="33559712"/>
    <dbReference type="InParanoid" id="A0A1Y1US86"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="6">
        <location>
            <begin position="83"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="7">
        <location>
            <begin position="196"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="50886" checksum="6ACA4E8E9CB3D1F1" modified="2017-08-30" version="1">MSDLQATLTKEPNGSLTVTGYESLKYNFHYTSPVFDVANKKLAEIYEKWGRVLIVIDTIVHPIYQSTIETYFKHYGIPITWKVVAGGELNKTMDTMLEIVDAMDSFGIVRTEPTLVIGGGLVTDVAGYACASYRRTSNFIRIPTTLIGLIDASVSIKVAVNHRKLKNRLGAYHAPLHTFLDFSFLRTLPVGQIRNGFAELIKIASVGDKPVWELLVKHGKELVETGFGHKDGGESVKAPGLEVCHRGIETMLQLESPNLHEIGLDRVIAFGHTWSPTLELTPRIPLRHGHAITIDMAYSITLAHSRGLINDVQRDEWFHLISSVGLSMDHEAFDEQLIEAATEAIKKTRDGKQRFAVPDGEFGKCLFLNDVPLSELKSILKVHKDFVKSRYGSGDGLEAYVDAGDLGADPEKYAAKGQPKDTADSLKRNGIEGVKVKTAAVAAGAVPIDGTGHVVNGMTATRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US98</accession>
    <name>A0A1Y1US98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874111.1">
        <property type="nucleotide sequence ID" value="XM_022014913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US98"/>
    <dbReference type="GeneID" id="33556721"/>
    <dbReference type="InParanoid" id="A0A1Y1US98"/>
    <dbReference type="OrthoDB" id="2568950at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013322232" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="154" mass="17066" checksum="2CB5AC7685CBBB37" modified="2017-08-30" version="1">MFSIKALSIIGALVGMTAAYDERMEVKKPDGMSMQLFERAFFSACYGFEPIRTVEGPWFGPDAFFQPGDYQGKNNETIALASCTYFNDYHHPVGVTAGVAQLLGGNTTEPCPYDVCTWQYQADGTYLSGLISHAPDFGYQYNNFSTWGCFKPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USE4</accession>
    <name>A0A1Y1USE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_612552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874598.1">
        <property type="nucleotide sequence ID" value="XM_022014403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USE4"/>
    <dbReference type="FunCoup" id="A0A1Y1USE4">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USE4"/>
    <dbReference type="GeneID" id="33556211"/>
    <dbReference type="InParanoid" id="A0A1Y1USE4"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX40919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="252" mass="27075" checksum="7654A5E5B9919FBA" modified="2017-08-30" version="1">MATVGIPPSLLLLILDVHPTSWSILSSGSRTAKELEGSATISRAPVQSLGLAEFLNTLMIWLNAHLAARWGNEVVVFAAGAGTARQVYPSGLAGPSNLRSNVYQPFNMLDLELERALKSVEQEEQHLNDPPSIVSALTKALCFINRVIPQDSAESEVANTPDRLQPRIMIINATPSPTGEGEDGGSQRGGYVGMMNCVFAAQKGKVPIDVLTLPPEGGAPIFLQQAAHLTEGIYWRWNGRVGLLQYLHVSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USL1</accession>
    <name>A0A1Y1USL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_574626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874670.1">
        <property type="nucleotide sequence ID" value="XM_022013073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USL1"/>
    <dbReference type="FunCoup" id="A0A1Y1USL1">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USL1"/>
    <dbReference type="GeneID" id="33554881"/>
    <dbReference type="InParanoid" id="A0A1Y1USL1"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="116"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="186" mass="21009" checksum="1573E625C9758036" modified="2017-08-30" version="1">MSAEKKDSVILQTSDDEQFTVEKKVAERSAMIKSMLEDLPSQDSMIPLPNVSSSVLAKVLEYCDHHKNEPLPAADADADDSRKKTSEIGDWDSNLSQVDQEMLFEIILAANYLDIKPLLDVGCKTVKLTTDQSLSSNMIKGKSPEQIRTLFNIQNDFTPEEEEQIRKENEWAEEWVQNRKSDGLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USQ9</accession>
    <name>A0A1Y1USQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_15378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874356.1">
        <property type="nucleotide sequence ID" value="XM_022012034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USQ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1USQ9"/>
    <dbReference type="GeneID" id="33553842"/>
    <dbReference type="InParanoid" id="A0A1Y1USQ9"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="545" mass="58411" checksum="7423AEAFA8FD8C9E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USY2</accession>
    <name>A0A1Y1USY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_617281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874100.1">
        <property type="nucleotide sequence ID" value="XM_022014909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USY2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USY2"/>
    <dbReference type="GeneID" id="33556717"/>
    <dbReference type="InParanoid" id="A0A1Y1USY2"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="225"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="536" mass="60526" checksum="899DD798C9AA7B22" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT60</accession>
    <name>A0A1Y1UT60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874295.1">
        <property type="nucleotide sequence ID" value="XM_022017680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT60"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT60"/>
    <dbReference type="GeneID" id="33559489"/>
    <dbReference type="InParanoid" id="A0A1Y1UT60"/>
    <dbReference type="OrthoDB" id="2563128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="418" mass="44905" checksum="B37330B93DE4CBEF" modified="2017-08-30" version="1">MTSTVIIDDASPQIQYFSLPKNGGGGWTTFMNDSVQGHFYGQTRHLSTGLGDYLSLTFRGSGVSAIGPYNENHGNYTVTIDDKSIGQFSGVADWQMTNLLPDITDLDPMVDHTLVITNAGNPGKPNSVYLSFDYIQVTYPLPSQEYTSAVDDTSSAFAFDTGWTSKNDSSGICFTGYAVQLFGTVTQGSGNYTVSLDSGEEQQFNSNDPVNTLRRVPIYTALGLEQGPHTLTLRNVPTNQGDHCNIDYAVVNSTVEAESSSLRPTTSVGGNIENAVSSSSNPVSRTASPIAAVGGPRLPTGMNISGAISIFGPSPSLPSPSHQQSAVTISTTDTGSSSDDHNERDVSTGTVAGICSVLTIALIAVMIGFCVWRKKRLRGEDDESDFDDQELMIEYEAPTARSLIISWFHRRRDTMGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU79</accession>
    <name>A0A1Y1UU79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_48738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874876.1">
        <property type="nucleotide sequence ID" value="XM_022012921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU79"/>
    <dbReference type="STRING" id="4999.A0A1Y1UU79"/>
    <dbReference type="GeneID" id="33554729"/>
    <dbReference type="InParanoid" id="A0A1Y1UU79"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="536" mass="59609" checksum="D05C83D6EB2EDF83" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5J5</accession>
    <name>A0A1Y1U5J5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_606295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000027">
        <property type="protein sequence ID" value="ORX33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867649.1">
        <property type="nucleotide sequence ID" value="XM_022014010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5J5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5J5"/>
    <dbReference type="GeneID" id="33555818"/>
    <dbReference type="InParanoid" id="A0A1Y1U5J5"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="96"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="190"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="278" mass="29858" checksum="2A80F3A52B460632" modified="2017-08-30" version="1">MSDAATHAVAGAAGGCVSLAITYPLVNLSTRKAVKSEEGHDTIVASLKRIYAREGIAGLYSGLESSLLGMALTNGIYYASYERVRAIMLKRKEGALTTAQGITAGLIAGITTSMITNPIWTIQVAQSTRGKESIAVAAQRIYNEAGVLGFWRGIGPALVLVLNPVIQYTTFERLLALILTLRKSPTRSSLTSLDLFILGAASKLIATGSTYPIIVVKSRLQAATHKYKSSLHAILHILRKEGLHGLYAGLVPKLVQSVLTAAFMFVAQRRIYEMLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5Z9</accession>
    <name>A0A1Y1U5Z9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isy1-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_654163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867788.1">
        <property type="nucleotide sequence ID" value="XM_022018758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5Z9"/>
    <dbReference type="FunCoup" id="A0A1Y1U5Z9">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5Z9"/>
    <dbReference type="GeneID" id="33560567"/>
    <dbReference type="InParanoid" id="A0A1Y1U5Z9"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="300" mass="33718" checksum="DFE2FDA979A401BB" modified="2017-08-30" version="1">MARNSEKAQSMLYRFRESQAIEMGMGNRMKGERRPRMASSVTSLRDCERFRGDILREISRKVSKIQDATLTDYQVRDLNDEINGLMREKRHFENQIVSLGGANYKRGNQAMLDEDGKEVPGTRGYKYFGRAKDLPGVKEMFTKSAQQATEESARNASFQMFRHQGPDYYGDVDDVDGGLLEEEDKLAREEWDAAVARTSATLSVDGTIPYPLDPTTKAGTKRKAKGKPKSRSKRKTGENDAIEEDEGEEDGEDISAAISATFGGVLDAQSLHMPEVPTREQMGEILLEVRKKALREEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6I5</accession>
    <name>A0A1Y1U6I5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_562673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867961.1">
        <property type="nucleotide sequence ID" value="XM_022013020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6I5"/>
    <dbReference type="FunCoup" id="A0A1Y1U6I5">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6I5"/>
    <dbReference type="GeneID" id="33554828"/>
    <dbReference type="InParanoid" id="A0A1Y1U6I5"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="39"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="247" mass="27948" checksum="8B758C616C914951" modified="2017-08-30" version="1" fragment="single">IVKIMGYNTEAVTAIRETQRMLGGIVEAIENDADYWYGECQLPPTYQTFFQLHMMYLLILITRLRALPVAAPSKSHPIPELPDPSPPSTPRPPPAMSPAVTSSTSLFSKPTSGRYTAEIINNFFELAESQMRRALGRNERERVIQNIGLDYVLALQMSEEARDRESADAELASWLWRNLFASRGLGPPSPEFVAPDEVDAYSVTEIYMLDQLERVVRFVRREMARLDQLADRDVLDGNIGAWSRVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7P8</accession>
    <name>A0A1Y1U7P8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="12" type="ORF">BD324DRAFT_638105</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7P8"/>
    <dbReference type="FunCoup" id="A0A1Y1U7P8">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7P8"/>
    <dbReference type="InParanoid" id="A0A1Y1U7P8"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="244"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="526"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="487"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="388"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="640" mass="71460" checksum="7674DE7F88791EFE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7S4</accession>
    <name>A0A1Y1U7S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_653743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868340.1">
        <property type="nucleotide sequence ID" value="XM_022018697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7S4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7S4"/>
    <dbReference type="GeneID" id="33560506"/>
    <dbReference type="InParanoid" id="A0A1Y1U7S4"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="157"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="341"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="446"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="817"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="928" mass="103402" checksum="F73C274F42D13682" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7V0</accession>
    <name>A0A1Y1U7V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_643511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868389.1">
        <property type="nucleotide sequence ID" value="XM_022017552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7V0"/>
    <dbReference type="FunCoup" id="A0A1Y1U7V0">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7V0"/>
    <dbReference type="GeneID" id="33559361"/>
    <dbReference type="InParanoid" id="A0A1Y1U7V0"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="14520" checksum="F7DF69E660D8D6C6" modified="2017-08-30" version="1">MEKFQELKHGKKLTYIIYGLSDDKTSIIVKNTSSDKDFEKFVSELPEADCVWAVYDYEFELSAGEGKRNKITFVAWAPDDAKIKSKMVFAASKDALRRRLDGIQLEIQATSLDEITSEALFEKATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Z1</accession>
    <name>A0A1Y1U7Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_610164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868406.1">
        <property type="nucleotide sequence ID" value="XM_022014192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Z1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Z1"/>
    <dbReference type="GeneID" id="33556000"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Z1"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="11624" checksum="F9E55365C394F91B" modified="2017-08-30" version="1">MSSSNEPSKLNGQVNSIVGSAKELVGSAIEAGYQAVGGSSEPSSFTTSGKEQHAKGEAEIKAAEAKGYAEGVGDRLEGKKDSIVGAITGDKAQQTKGNLQNEAGHAKMSANDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8K1</accession>
    <name>A0A1Y1U8K1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_653148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868633.1">
        <property type="nucleotide sequence ID" value="XM_022018618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8K1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8K1"/>
    <dbReference type="GeneID" id="33560427"/>
    <dbReference type="InParanoid" id="A0A1Y1U8K1"/>
    <dbReference type="OrthoDB" id="5569309at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="39298" checksum="50D018392A6792DA" modified="2017-08-30" version="1">MSDTQYSGSLLNKRKAELSEIASSLGLADPDAKMTELIKTIQDHLEKNEKDLMSTPKYKGLYVRKGRVVLVAPRHHDTETPAPEVVKTVEGTVKKPRKSMNKALDRIADAIDPANIALPESPINVSKIQHEAQQLSKALVPSNGLPKDVSVRARQVSNKLVKIGRDSQSRVDKGVSLLREYLSNPEHIVASALAVELAFLFAHVLQFYDHTIFFPPPGGASGTFPSLFHSLFFWMPKFHLDMRIPDAIGLGYRAEIWPAVSWWFSTTVLPALAGSTVITFGKTHKARSSHAGRGTTSQSGLPRPDPFTFALFRFALLLYPLTSAAPSSLVDALEMSGNLQGRALGAGLLAMLLLAERLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8L1</accession>
    <name>A0A1Y1U8L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_635574</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868626.1">
        <property type="nucleotide sequence ID" value="XM_022016822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8L1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8L1"/>
    <dbReference type="GeneID" id="33558631"/>
    <dbReference type="InParanoid" id="A0A1Y1U8L1"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="940"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="689"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="235"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="888"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1248" mass="135347" checksum="EA4EFFF1EAA0EDF4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8M7</accession>
    <name>A0A1Y1U8M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">BD324DRAFT_635688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8M7"/>
    <dbReference type="FunCoup" id="A0A1Y1U8M7">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8M7"/>
    <dbReference type="InParanoid" id="A0A1Y1U8M7"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="256" mass="28057" checksum="AA7E3F79D84BD121" modified="2017-08-30" version="1">MILASSSRITLDHLARWSTRPTLQQCRTLASDAYFKRPPQTSTTPGPASSTSSSTVPDEATNDTPSNLTPAQKELIDRIIRVDQAGEVGANWIYRGQKLAMQLKGDNKSAAQIEAMWETERHHLATMDLLRKQHNVRPTALYPLWQAMALALGTSTGLMGREAAMACTEAVETVIGEHYDDQLKALKPLIETLSISDPAHPSLPLLRDILTEFRDDELEHLDTAVEEGAQKAPGHALLSAVIELGCKAAIKVCERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8N1</accession>
    <name>A0A1Y1U8N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase NAD binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_145410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868646.1">
        <property type="nucleotide sequence ID" value="XM_022012015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8N1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8N1"/>
    <dbReference type="GeneID" id="33553823"/>
    <dbReference type="InParanoid" id="A0A1Y1U8N1"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="232"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="534" mass="60603" checksum="08CFF3FD13C39537" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8U6</accession>
    <name>A0A1Y1U8U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_657808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868732.1">
        <property type="nucleotide sequence ID" value="XM_022018873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8U6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8U6"/>
    <dbReference type="GeneID" id="33560682"/>
    <dbReference type="InParanoid" id="A0A1Y1U8U6"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="601" mass="68919" checksum="61EF7DD8F0C54E88" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U918</accession>
    <name>A0A1Y1U918_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_643446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868765.1">
        <property type="nucleotide sequence ID" value="XM_022017545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U918"/>
    <dbReference type="FunCoup" id="A0A1Y1U918">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U918"/>
    <dbReference type="GeneID" id="33559354"/>
    <dbReference type="InParanoid" id="A0A1Y1U918"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="375" mass="40221" checksum="812187C3A855A016" modified="2017-08-30" version="1">MTSAPVFNFGGGGTRLADIKVEGESRVQNNFARSARWCADGSSILVTAEDRIIRVVKSLKETTIIACPDAVVSTSWYPSASGDNPATHCFVAGIRDSPVRLVDASDGRIRAQYPIVDHRERVIAPHSLAFNPDASKLYCGFDSAIEVFDVSNPGHGTSDRLVLAKDAQKGLVSALAFAPDYSGIFAAGDYNGAVALYSEGSAAPIQHVDGVVGGGVTQIAFNPIRPTMMLVAARRSGEIQAFDTRDLSKPVKGLQRDGWTNQRLDFGLDPWGRYLAVGDQRGTVKIWDTETLELVCARPLSNDAIGSVQMHPLEPWILTASGSRKTIDSTDSDNDSDEEASDNESSGSSDEDHTHSSHVLPPVSRSLGLALWSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U934</accession>
    <name>A0A1Y1U934_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868803.1">
        <property type="nucleotide sequence ID" value="XM_022018641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U934"/>
    <dbReference type="STRING" id="4999.A0A1Y1U934"/>
    <dbReference type="GeneID" id="33560450"/>
    <dbReference type="InParanoid" id="A0A1Y1U934"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF22">
        <property type="entry name" value="SLL0786 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="190" mass="21493" checksum="5A241FADBA0DFED9" modified="2017-08-30" version="1">MSKSDRPRFNIKVAETKDEIEACYDIRIEVFVVEQGFPLDVEIDDYDKTATHLLLTTPVSSPPPESTASLTPSLEPSSASTSQKPIGTIRWNPSVGKVARLVVAKEYRKYGFGRVLMDELHQHVKSTSVDKRSELKTAKEVNGKEHVHLWLNAQMYAIPFYVKMGYEQVGEEFDEDGAPHVKMVRDLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U960</accession>
    <name>A0A1Y1U960_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_647084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868335.1">
        <property type="nucleotide sequence ID" value="XM_022017636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U960"/>
    <dbReference type="STRING" id="4999.A0A1Y1U960"/>
    <dbReference type="GeneID" id="33559445"/>
    <dbReference type="InParanoid" id="A0A1Y1U960"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011817689" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="35"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="599" mass="65484" checksum="A3380D0EDA99930F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9I2</accession>
    <name>A0A1Y1U9I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Opioid growth factor receptor conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_634494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868930.1">
        <property type="nucleotide sequence ID" value="XM_022016735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9I2"/>
    <dbReference type="GeneID" id="33558544"/>
    <dbReference type="InParanoid" id="A0A1Y1U9I2"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="2">
        <location>
            <begin position="85"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="317" mass="36561" checksum="6F47126AA32FFDB8" modified="2017-08-30" version="1">MSSAVRRILCFTANRRRAAQMANNIHLPFSGNGFILGDPSGSSIAFQSGHPASADYSEIRRLTNRPQDIDDFLAEYPDLTPDLESNVNLDFYRGTGKMQPGNMAYEEFMSAFEKDYEELELNHGYIQWLFPIREKGLNYQSRPLQLHEIQMMSSDRAVLARLLRSYRMMLAFYGIDFNNGHLRLTVDHLERLFNLYHHPHNLLRITRILKCLSEFPLLKPHVPLLILFFTALHSEGYIDLSPAPHHNMHGQSLDNWWSNCIRDQDLRTRVRRIVTERGPCAGFRWGFEQFDDWYAGCQKGWTGALGGFLDDEGTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9K2</accession>
    <name>A0A1Y1U9K2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">BD324DRAFT_634578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9K2"/>
    <dbReference type="FunCoup" id="A0A1Y1U9K2">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9K2"/>
    <dbReference type="InParanoid" id="A0A1Y1U9K2"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="276" mass="30088" checksum="00C43303B5A53567" modified="2017-08-30" version="1">MKDWTAEEDPEELPPPSETTVDGITTIITWKLDEHDRKVKVTRRVRRKMQTQNVSHTVAERRRLPKFGDDKGKATGPDRKTTIVGENIHFKVAPVSAKANEAAAEPDAPKLAAGKAVICRLCKGGHFTAKCPFKDSLAAIENVDMDDGGEAPAADGMGGILARGAGAGGKYVPPGQRAGGGAGESMYRNRDDLPTLRITSLSTDAEDEDLRELFAPFGKVARANVVRDRETRESKGFGFVSFESRRDAEKALQKMNGHGYDSLILSVSWSLPREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9K8</accession>
    <name>A0A1Y1U9K8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868961.1">
        <property type="nucleotide sequence ID" value="XM_022018587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9K8"/>
    <dbReference type="GeneID" id="33560396"/>
    <dbReference type="InParanoid" id="A0A1Y1U9K8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="292" mass="31591" checksum="501E518AD6F17E55" modified="2017-08-30" version="1">MASSSSSSVVFSSATSLTSDPVSSVRLSSPSTASITTSLLHAITTLKPLPTSSHLPIHRSSSSDLSSTSSGIDLSSTLLSPSPDIPTPTSLTASLESVASTLPRYLIAGGVILAVVIFIGILSFWWKRRLRRIRHFDEEDHFCFEKRRQERLNSSTPPSHSPTPKRPQRMAGTSSSEALTAQQRPKHRSRAPSVPPPPMAKSPFSDSPPYVVISQASDSTLHLDTQPSPTSPASPTSPLLSNDPSAPLCPPSRQIRQSTATSQLDVESTRLSHVEKDQAELLEYLQRDEKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9U4</accession>
    <name>A0A1Y1U9U4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_134540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869040.1">
        <property type="nucleotide sequence ID" value="XM_022012000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9U4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9U4"/>
    <dbReference type="GeneID" id="33553808"/>
    <dbReference type="InParanoid" id="A0A1Y1U9U4"/>
    <dbReference type="OrthoDB" id="2596590at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="691" mass="72019" checksum="57309CC9C2FA547B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9X3</accession>
    <name>A0A1Y1U9X3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_653085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869071.1">
        <property type="nucleotide sequence ID" value="XM_022018605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9X3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9X3"/>
    <dbReference type="GeneID" id="33560414"/>
    <dbReference type="InParanoid" id="A0A1Y1U9X3"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="243"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="396"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="585"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="656"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="711"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="80175" checksum="435245F103860555" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAE2</accession>
    <name>A0A1Y1UAE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_110486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869205.1">
        <property type="nucleotide sequence ID" value="XM_022011931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAE2"/>
    <dbReference type="FunCoup" id="A0A1Y1UAE2">
        <property type="interactions" value="1"/>
    </dbReference>
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    <dbReference type="GeneID" id="33553739"/>
    <dbReference type="InParanoid" id="A0A1Y1UAE2"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="52994" checksum="3B79C99BBD7F2D44" modified="2017-08-30" version="1">MANMVPQEELPVLEAFINIRNRLTALKKDTTRFIRAQDVMSIYNSVVKQVTRLNDIRDEQASHTSLATNNASSSSSTSANGANGSGPAPPEPNRVDTIIADVFGLLSLFFLTIGKSRETPATYSQIASMRQILLHMNETGAYTEAYLEPFRHRLDALREILEQDSRDGKHPEPIVRLMRKKLDGVERQLNDMFESVSVISVELVPLHQKLVGLRKQLAILSAEERPQRAEYKAVLEELRRIDSKRVDGKFLGPGGSSVPEGQALLTGILDQCFEMAHDLKAREAEEDVSPTLKPIYDRLSEIKAQLERLLLTHRWTLRETDLYNYAMSLREIDAMRVDGKFVDAEGNKADGQYALLFLLRRSHQLIYRLISESEPISEELMPIANKLSTIKKCLNEVLKYGGPYTPRDLYPYHLALHQIDSLRKDDKFYADDGSIPEGQAILVAQLSEAHELLEMLKETMSDEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAI2</accession>
    <name>A0A1Y1UAI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_603887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869259.1">
        <property type="nucleotide sequence ID" value="XM_022013966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAI2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAI2"/>
    <dbReference type="GeneID" id="33555774"/>
    <dbReference type="InParanoid" id="A0A1Y1UAI2"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="101"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="710" mass="79083" checksum="44065533A1645B31" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAK9</accession>
    <name>A0A1Y1UAK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868393.1">
        <property type="nucleotide sequence ID" value="XM_022016921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAK9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAK9"/>
    <dbReference type="GeneID" id="33558730"/>
    <dbReference type="InParanoid" id="A0A1Y1UAK9"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31339" checksum="66CCAECECCD26FC8" modified="2017-08-30" version="1">MFRSAWTGTEIVKAILKTKRCRHLRCYSISSGPASSPTLLVRPFGNPDPDILQSDFTLLPHFYTAAETRQLLAAALWKLDRGDSTRRRRSGPSHPQAQLPHTSSANSPPLADLFHGQYGFEPGHYDAVIHQYRESLMSTLPTPSSSSYPDLITLLHKAYALLLPDSTSIANGTPPSNVITHLLHLSPEGQIKGHVDNLEASGGVISGICLGADRILRLSKGEAGSSEKGWDVLLQNGTVYLQRGRLRYEYEHSILPYDSTDSNWDGRPLVPGHRVSVMIRDAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB14</accession>
    <name>A0A1Y1UB14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microtubule associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_657255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869399.1">
        <property type="nucleotide sequence ID" value="XM_022018861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB14"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB14"/>
    <dbReference type="GeneID" id="33560670"/>
    <dbReference type="InParanoid" id="A0A1Y1UB14"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="653" mass="73584" checksum="680555BEAD7C86C0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB17</accession>
    <name>A0A1Y1UB17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_631918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869421.1">
        <property type="nucleotide sequence ID" value="XM_022016478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB17"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB17"/>
    <dbReference type="GeneID" id="33558287"/>
    <dbReference type="InParanoid" id="A0A1Y1UB17"/>
    <dbReference type="OrthoDB" id="2575262at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="503" mass="54989" checksum="7546B9B828B379C6" modified="2017-08-30" version="1">MPIATNVLSEHSKAKVQPLCGRPDYASITRNLLALSQDVTALAALSYEATASLAHDIYQRLLSRIGLSQALVKCEEIPRSKTQPEGARGLAVVVLGSSHAGQTLTLMLAKSGYTVFPLVPLPSPDSPPTSTPLSSLLLKWSSVQKRLKVKDPNHPGAVVPLIMDPLSDSDALRQHSEGRYVHAGETIRAYCRENRLILVAVVCAASSAPATNSYDRSRHVAQVQAFGNEGSPNLSDVFTSPPYLSPRLLPEDKPSLQQLYQQDLHADNRPHPSFHPDDEHHLFTFYRSTVLEPLAVVRELRDQLSSTGDLSRSNGRVIFINEGHAGSYKGCGLVNRVIDAARSEAARWLREQMRFEGIDVCEVKTGPLAPRLKTKGGYHLRHSSDESTESAGGQKLQWIEKDGVHSDVGTAAQGMDGQSPEAIYNSRLALISRFWAVDDALLFSAVRRAIEDRHPRYRHHAGISPILASIGEVTPGSGLVKMLGRWILSRLLMPKAGRRSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBA6</accession>
    <name>A0A1Y1UBA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_609570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869518.1">
        <property type="nucleotide sequence ID" value="XM_022014159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBA6"/>
    <dbReference type="GeneID" id="33555967"/>
    <dbReference type="InParanoid" id="A0A1Y1UBA6"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="572" mass="63888" checksum="83BD915BC3847A37" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBC5</accession>
    <name>A0A1Y1UBC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_632469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869531.1">
        <property type="nucleotide sequence ID" value="XM_022016519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBC5"/>
    <dbReference type="GeneID" id="33558328"/>
    <dbReference type="InParanoid" id="A0A1Y1UBC5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013322230" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17733" checksum="D1330635BE9E01F5" modified="2017-08-30" version="1">MIGLLVPWRLRAMAVVLRISVNRTWSHPILPIYKYWIVIKMSTPSATQATTPRHTPYTRDPNARTNLSLFHHVLQFQRFLPSASRSKIVTKRAATRSEARTKDGQIRHVTKHDSSDSPSSCAHRANPEISTYGGSTSLILEHQWVHWNSRHISDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBD2</accession>
    <name>A0A1Y1UBD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_632518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869548.1">
        <property type="nucleotide sequence ID" value="XM_022016526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBD2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBD2"/>
    <dbReference type="GeneID" id="33558335"/>
    <dbReference type="InParanoid" id="A0A1Y1UBD2"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="390" mass="41702" checksum="07A792D2CBA1634F" modified="2017-08-30" version="1">MVSSPSPMSTTETSPTATSPSVVPAHNGSAAAAVAAEQPAAAAPAPHANPKVAELQVMFPTIEVEVIEMILESCGGSQDRAIEQLLSMTDPEFKPDELAHSRQEEASQVDLDAEFARSLHMQDEERMRQGGRALPYQPRVRTRPLPGDGQQAYFNPTTAGAPPRDENPPGMLAMEDKLNQYAEIGKQTFSSIFNKAKAKYSELQQTAAANTAAREESDRQRVGQDRMGASWRSPSPQGYGTPTPGGARGGQQNTRGMWADDSSSFSSQSTEPAPKAARWQPSDAYDDPLPAIPPTNKIEVTGRRSPAAMEKPAAPSGKIDPAKLGILPKKRVDLLSTSPPANPSMEQEEDDPNPSLPSATKSIVNQIPKTPPAGSSTYNGDSDDDLEYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC06</accession>
    <name>A0A1Y1UC06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_609353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869737.1">
        <property type="nucleotide sequence ID" value="XM_022014153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC06"/>
    <dbReference type="GeneID" id="33555961"/>
    <dbReference type="InParanoid" id="A0A1Y1UC06"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19237" checksum="CC4AE82D22FCCC03" modified="2017-08-30" version="1">MIDPMAMDIDLSLQELIHRDQHHPGSSRHQRTRYTGRASHVPNSQSLRQPASGHPYRTFRRPPTAPRAMIHSPTVFFRPFPSDASFNEARELFESTIGPIQSLVRYADGVRVTFKDVQSASRAIAMFDRRFWRDTDIWIRVERCGVGLTLRSSRTTSQSSEKARRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCG2</accession>
    <name>A0A1Y1UCG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_631296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869863.1">
        <property type="nucleotide sequence ID" value="XM_022016418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCG2"/>
    <dbReference type="GeneID" id="33558227"/>
    <dbReference type="InParanoid" id="A0A1Y1UCG2"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="372"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="690" mass="78909" checksum="F579A507267C63F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCY5</accession>
    <name>A0A1Y1UCY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_629518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870040.1">
        <property type="nucleotide sequence ID" value="XM_022016216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCY5"/>
    <dbReference type="GeneID" id="33558025"/>
    <dbReference type="InParanoid" id="A0A1Y1UCY5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="74" mass="8108" checksum="C83C0AFFE6BAD2A5" modified="2017-08-30" version="1">MRALSVLSHALTPLGQALSAFRVVVLIGKHSERTIRISCHYHLMVLSSIASPLRKDARDDGVTDVEEGVSKCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDF0</accession>
    <name>A0A1Y1UDF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_59703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869710.1">
        <property type="nucleotide sequence ID" value="XM_022013872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDF0"/>
    <dbReference type="GeneID" id="33555680"/>
    <dbReference type="InParanoid" id="A0A1Y1UDF0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="161" mass="18781" checksum="5FB88FF6DA25DA3F" modified="2017-08-30" version="1">MCTSVARVQYRCQESLRGRIRRVDSLHRGPIPAWLQVHSVYADKLEHLSLRHRHSVLASTVHHHRSSFYSSRYYRFPCGHFQKQHPFPAFLYIAVRCRLDLGSSGPYHRMELSYPVGLDRETRRAAEDDMPRGDCRLVQRHGQFRKGSGNAKMRHTGLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDJ2</accession>
    <name>A0A1Y1UDJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_642777</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870257.1">
        <property type="nucleotide sequence ID" value="XM_022017504.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UDJ2">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDJ2"/>
    <dbReference type="GeneID" id="33559313"/>
    <dbReference type="InParanoid" id="A0A1Y1UDJ2"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="471"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="778"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1253"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="53"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX36128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1444" mass="162200" checksum="2FDF1526D27F144C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDP6</accession>
    <name>A0A1Y1UDP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_630987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869808.1">
        <property type="nucleotide sequence ID" value="XM_022016393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDP6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDP6"/>
    <dbReference type="GeneID" id="33558202"/>
    <dbReference type="InParanoid" id="A0A1Y1UDP6"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="43"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="362" mass="39662" checksum="375986E68AFDDA8D" modified="2017-08-30" version="1">MTWTHVGSIRSPALSTLRLSHTSTRSYTIPLTMRAILIKDGKGPADNLYIGEEATPKPKQGEVQVKNFGLNRMDLLQREGNYPLPPQASKTILGVEFAGTVSELGDGAKAFNVGDEVFGLAYGGAYAEYIANPEQMTLPKPSNLSWEEVGGMLETWLTGYQALFLEGGMKKGANVLIHAGASGVGIAAIQLALHVGHANKVFTTCGSDEKVKFLKQLGHDDRLHVINYKTQKFAEEIKTVADGVDLIVDFVGKDYFEDNIASLNRDGTMIYLAFLSGAKVENANLANILYKRLTIKGSTLRSRDPAYQGRLLKEFKENALGLITDGKMNVLIHEVYPWDKVADAHREMQANKNSGKIVFKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE67</accession>
    <name>A0A1Y1UE67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870441.1">
        <property type="nucleotide sequence ID" value="XM_022016118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE67"/>
    <dbReference type="GeneID" id="33557927"/>
    <dbReference type="InParanoid" id="A0A1Y1UE67"/>
    <dbReference type="OrthoDB" id="2585251at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="563" mass="62104" checksum="1DB6EB3351D25EEC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEF2</accession>
    <name>A0A1Y1UEF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_628716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870503.1">
        <property type="nucleotide sequence ID" value="XM_022016139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEF2"/>
    <dbReference type="FunCoup" id="A0A1Y1UEF2">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEF2"/>
    <dbReference type="GeneID" id="33557948"/>
    <dbReference type="InParanoid" id="A0A1Y1UEF2"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="129"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="29551" checksum="5FAF821777188F5A" modified="2017-08-30" version="1">MPKAAKGKSKPAAAPYGTKKSTKTATNPLFEKRSKSFGIGGDVPPKTDLTRFVKWPGYVRLQRQKVILNKRLKVPPAIAQFSHTLDKNTATQLFQLLNKYKPESKQEKKARLLSEAESREKSGDKATTHQTKKPNYAKYGLNHVVALVEAQKAKLVVIADDVDPIELVVFLPALCRKMGVPYCIVKGKARLGLITGKKTSAVVAIDEVRSEDSQALANLVSACKANYLDKADEIRRTWGGGIRGNKSIAMLRKRAKGLGQDAKKIDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF89</accession>
    <name>A0A1Y1UF89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_630462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870303.1">
        <property type="nucleotide sequence ID" value="XM_022016334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF89"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF89"/>
    <dbReference type="GeneID" id="33558143"/>
    <dbReference type="InParanoid" id="A0A1Y1UF89"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="401" mass="44688" checksum="0C511F08348A7DD6" modified="2017-08-30" version="1">MSNNPGATEQLPDEMGEPLEKSLDHLVEHSRPWHDVGENDELAPSEKRQDLIHAHGGESKSWIKKLWPSSETVDHLFKYEHMGNYVIDRQNGRKIFESMPLYVRVGMHLLFVSGATYMSYPSIESMLESKSQRQGELYDETGPGVKEHIQSFIDTYKLPLNELLIQDLDKYPTFNSFFSRRLAPSARPITSPEDTSIVCVPSDCRLTVFQTVDQAKQFWIKGKQFTLKTLLCGDNGEEDEGLQAVWGDEKSAVAVCRLAPQDYHRFHSPVEGTLVSLKDIKGTLYTVNPQAVNEDLNVFTLNKRAVMLIHANLGPGREQVPVVLVAVGAMLVGSIGWSKKPGDKIAKGEDMGWFQYGGSTVICVFPSATGITFDEDLVTHSKASMETLVRVGMEMGKVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFD9</accession>
    <name>A0A1Y1UFD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_627090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870832.1">
        <property type="nucleotide sequence ID" value="XM_022015961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFD9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFD9"/>
    <dbReference type="GeneID" id="33557770"/>
    <dbReference type="InParanoid" id="A0A1Y1UFD9"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="190"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="367" mass="40970" checksum="A02A8CC66542FBEE" modified="2017-08-30" version="1">MTSPTSLEALARAAIFPHKGEQLGPNLLGYFLDSLFLGFEFMLFAHWAAWSWKDRALIRILVCCSVVFSLAVSCFNLSCLLHLFGFNFGEYANFFKADYIAWFGVLSVLPTVSTQLFYIDRAYRLNGKSLLIAVPTFALTLATLASGVGRTIILLSTKVETGYNVRVAVQQPTYEAMNYLWIISTLLNELTLAGLIVFGLTKSKSEWPQTSSTAQKALFLTVEAQLPSALIFLILALVRLIRPTSTVGTFFEHWHTKVFTLGLLVLLNSRFSLLKTSDGSENTWNKGASHLHQATINVLTETYIESSRVDPPKVGLNRDFAQRNSLDAISEDEDKDPQGYNDLSYMQNDSSMGLTTNYPEDIKVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFJ9</accession>
    <name>A0A1Y1UFJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_628157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870385.1">
        <property type="nucleotide sequence ID" value="XM_022016092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFJ9"/>
    <dbReference type="GeneID" id="33557901"/>
    <dbReference type="InParanoid" id="A0A1Y1UFJ9"/>
    <dbReference type="OrthoDB" id="5399848at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="262" mass="29467" checksum="E16649B55505A79A" modified="2017-08-30" version="1">MRLCQNRPDGGFSAHVEFGGQTILSTCFDDTILIPLGSWAFILFTGMSFLIFRRRGQASNVGDHLMNHGGKDVELSTATNHHPSHLVSESPATTTTSSPANRSTYPRLRKTLLVIITFLLVALVAMHALEIARLSANHQGIGLLPFVFVPLLLIIVSLYVPTTAWSRDGFTKPARPHGLVWLIGVTLYCLWMSATYGVKIWSLKAVYNVIGMRAYDGVNSQYKESDKVVDSVTILAVYYVFMMLYVNMIFFEYNVYGWKRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFN1</accession>
    <name>A0A1Y1UFN1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_487831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870417.1">
        <property type="nucleotide sequence ID" value="XM_022012922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFN1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFN1"/>
    <dbReference type="GeneID" id="33554730"/>
    <dbReference type="InParanoid" id="A0A1Y1UFN1"/>
    <dbReference type="OrthoDB" id="2413468at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="55161" checksum="23C7472EF4E4CAED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFQ9</accession>
    <name>A0A1Y1UFQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Urease</fullName>
            <ecNumber evidence="3 11">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_489307</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a nutritional role via nitrogen acquisition in the environment. Contributes to the central nervous system invasion by enhancing yeast sequestration within microcapillary beds (such as within the brain) during hematogenous spread, thereby facilitating blood-to-brain invasion by C.neoformans. Affects fitness within the mammalian phagosome, promoting non-lytic exocytosis while delaying intracellular replication and thus reducing phagolysosomal membrane damage, events that could facilitate cryptococcal dissemination when transported inside macrophages. Urease activity is also associated with the regulation of key intracellular metabolic pathways, including melanin biosynthesis, polyamine biosynthesis, as well as intracellular levels of proline and reactive oxygen species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="13">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870445.1">
        <property type="nucleotide sequence ID" value="XM_022012927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFQ9"/>
    <dbReference type="FunCoup" id="A0A1Y1UFQ9">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFQ9"/>
    <dbReference type="GeneID" id="33554735"/>
    <dbReference type="InParanoid" id="A0A1Y1UFQ9"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Urease" evidence="16">
        <location>
            <begin position="395"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14 15">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX36344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="837" mass="91216" checksum="A1D3E10D40386D31" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGE0</accession>
    <name>A0A1Y1UGE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_624858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871151.1">
        <property type="nucleotide sequence ID" value="XM_022015741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGE0"/>
    <dbReference type="FunCoup" id="A0A1Y1UGE0">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGE0"/>
    <dbReference type="GeneID" id="33557550"/>
    <dbReference type="InParanoid" id="A0A1Y1UGE0"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="77"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="175"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="275"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="374" mass="39537" checksum="63CDDDC7E6A7B622" modified="2017-08-30" version="1">MSNYRANPFFATTNKFFLPSVGDKVDQAIDQTKQFGKDAKSKGQELYNKADLKVQDAKEAVKDTVKDLNPNTPTGADLYARFALAGALGCAVTHGALTPVDVVKTRIQLEPEVYNKGMITAFRQVTAKEGTGALLTGLGPTVVGYAIQGAFKFGGYEFWKKQAIDYLGVDSAREHRTAVYLGAAAIAEFFADVALCPLEATRIRLVSQPDFASGLVGGFGRILREEGPGAFYAGFGPILFKQVPYTMAKFGVFEVAVEQILSATGKSKDSLTGAQTQALNLSAGVIAGCAAAVISQPADTLLSKINKTKGAPGQSTTSRLIEMAGKLGAAGLFTGMGARLVMISTLTAGQFFIYGDIKRMLNATGGVEISKVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGT7</accession>
    <name>A0A1Y1UGT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870386.1">
        <property type="nucleotide sequence ID" value="XM_022018348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGT7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGT7"/>
    <dbReference type="GeneID" id="33560157"/>
    <dbReference type="InParanoid" id="A0A1Y1UGT7"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="99312" checksum="81194E0BB89CAB5E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGV5</accession>
    <name>A0A1Y1UGV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Etoposide-induced protein 2.4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_651242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870826.1">
        <property type="nucleotide sequence ID" value="XM_022018299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGV5"/>
    <dbReference type="GeneID" id="33560108"/>
    <dbReference type="InParanoid" id="A0A1Y1UGV5"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="486" mass="52909" checksum="D575ACDE3B743984" modified="2017-08-30" version="1">MLYRRQAGSSGTNHILHSPVVDSPSPPPRNVNQAFKPLRRESGTLYSTPSGQTGPSDPSRARYPIPSSSPAINGDGNGFGNGYGHGYGESEPSYFQPSYGMTSGNIGLGYGSSANTGSSSQYGYGGNMGSSAFAPGDDAKPLSMRSKEEWIAMVRHGLDNVARGFGDSSRLDKSWSMAWGDVELRSLILRSTLINLVSLLLLSFSPIVLSPALSLSPDAQDKARSVGLWYNVLLSWPVFVLCFWINAYWGPAISKRAQILLHPAYRHQPSSPIPSNRSSSSAPSDPLVWVFSTLQRLLMISDFTLMSRTILLVPVLGRPTAFAYMCIINAYYCFDYTFTSRGWSLTHRVIFMQERTLYMVGFGFPATFLSSFFTPLVNMAIFALIYPFFVLQALLARPPVPRSSLLPTTPSPHSSLPASPSEQHPSMTPNASSLSASRPTFGVPIFFFAKFALAALSYVEAAIGRHRTGFSGAGSSLRERSGKRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHU5</accession>
    <name>A0A1Y1UHU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871579.1">
        <property type="nucleotide sequence ID" value="XM_022018109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHU5"/>
    <dbReference type="GeneID" id="33559918"/>
    <dbReference type="InParanoid" id="A0A1Y1UHU5"/>
    <dbReference type="OrthoDB" id="2506317at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="164" mass="17783" checksum="C5B1FB1696CC5FFE" modified="2017-08-30" version="1">MSSSAGLGPISQQYAAAATVPLIKSPSLYLPRPIELPNDIHPLPEDITAYFVYPFTLEEHVLSIKPSPHEAIAAKRAHNAEILHQREVQEEQREKEALHKVAPGYNPTAVLLPTSSSPAPGPKPIVGTSTLNSRVGTIDRPAAQTSLDPMDDLVSQLELLESKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI08</accession>
    <name>A0A1Y1UI08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_427434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871164.1">
        <property type="nucleotide sequence ID" value="XM_022012758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI08"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI08"/>
    <dbReference type="GeneID" id="33554566"/>
    <dbReference type="InParanoid" id="A0A1Y1UI08"/>
    <dbReference type="OrthoDB" id="2595252at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="161" mass="14551" checksum="93858E9E0DC73AF7" modified="2017-08-30" version="1">MLKVDHRLSLSLFSVGSAINSVVGDITSGGASVLSDITSGGASVLSDITSGGGSVLSDITSGGASVVSAAASGFQSVTGAAGSVFTSITGAAASGVTGASSSAAGAAASGASAASSALSSASSAATTSGAAQPGAMFSSGLAWTAMVGAAGVAIGAGRVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI25</accession>
    <name>A0A1Y1UI25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_625114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871225.1">
        <property type="nucleotide sequence ID" value="XM_022015769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI25"/>
    <dbReference type="FunCoup" id="A0A1Y1UI25">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI25"/>
    <dbReference type="GeneID" id="33557578"/>
    <dbReference type="InParanoid" id="A0A1Y1UI25"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012033517" description="Matrin-type domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="306" mass="34705" checksum="8EA1AE4209B8418D" modified="2017-08-30" version="1">MSMTLLATFFLLNNFYTMTEYWVSKKQYWCKYCSIYIRDDAPSRKLHETGLKHQGNKERYIRDLYKSGNQAKREKAAEAAQIARIEASAEAAYAHDAHASSSRIRLHPTATFAPPSASRKTDKPKDKWANYTSAKDLGFDDEDTQKSSYQIEQELKGRAGEVGAWEDVVEAAPGHTLQATRSLAHSNADSDDEGEGFKFSHREKRPWHDVYDEGEWDPKAALSSLKLKKQDKSDGVKMEEQNGLDRKGWDGKIELQGHHLSSVKAQPEDKHETLDAEPDVKPEIPAAENAGSSLFKKRRPVQHRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI98</accession>
    <name>A0A1Y1UI98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">BD324DRAFT_623312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI98"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI98"/>
    <dbReference type="InParanoid" id="A0A1Y1UI98"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="544" mass="59084" checksum="D38E8D27613CF539" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIF4</accession>
    <name>A0A1Y1UIF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_399880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871779.1">
        <property type="nucleotide sequence ID" value="XM_022012682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIF4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIF4"/>
    <dbReference type="GeneID" id="33554490"/>
    <dbReference type="InParanoid" id="A0A1Y1UIF4"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="226" mass="25179" checksum="AFE27CE525B9370B" modified="2017-08-30" version="1">MSHEQIGLDPVIASSQSRTSTYQSPILLLLVGLPASGKTALAQCLVTESPALNLDSFSRKWIRASQDDSPNRRRQEVEDLVRDGLLAGDNVVVDRMNFDARQRAHFLDIARSLPMPTQTWCIILNTSLSAIKSRLESRTNHPTITTAEHGLDIIDKMKYQYRPPHPTLVEGFDRILQLEDADQPEGGLWSPERLRALLLRISERGHREPVGGPRFSSAPALGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIT3</accession>
    <name>A0A1Y1UIT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_578686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871947.1">
        <property type="nucleotide sequence ID" value="XM_022013335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIT3"/>
    <dbReference type="FunCoup" id="A0A1Y1UIT3">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIT3"/>
    <dbReference type="GeneID" id="33555143"/>
    <dbReference type="InParanoid" id="A0A1Y1UIT3"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="849" mass="93612" checksum="EECB00E2C96CD521" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIZ7</accession>
    <name>A0A1Y1UIZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Domain found in IF2B/IF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_574147</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872017.1">
        <property type="nucleotide sequence ID" value="XM_022013055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIZ7"/>
    <dbReference type="FunCoup" id="A0A1Y1UIZ7">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIZ7"/>
    <dbReference type="GeneID" id="33554863"/>
    <dbReference type="InParanoid" id="A0A1Y1UIZ7"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="185"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="312" mass="34190" checksum="10E1407ACEB9CC46" modified="2017-08-30" version="1" fragment="single">KKKKKQVVLDEVEDAPQAPVEPISAPAKAEESAPAVEEEAIPEATGSGAATPAEDASGAPAVDDGDLFADMKKKKKKKKEIPLDLVSDSAAVPDGLDVPIKKKKSRKPAEDFAKELDELEAENEDGAAGGEDGDLGDDVFEKANGDGEAGKEAWVLEGRDPTYPELLNRFFSLLHAHNPELAGEKRKYTIVPPQVAREGTKKTVFSNLTDICRRMHRQPEHVIQFLYSELGTQGSIDGAQRLVMKGRYTQKQIENVLRKYIVEYVTCKICKSADTLLGKENRLYFMTCETCGSRRSVSAIKAGYQAQGKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ58</accession>
    <name>A0A1Y1UJ58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_624231</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872009.1">
        <property type="nucleotide sequence ID" value="XM_022015672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ58"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ58">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ58"/>
    <dbReference type="GeneID" id="33557481"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ58"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="248" mass="26687" checksum="F621612242FC9D0B" modified="2017-08-30" version="1">MSLPSAASSSSTTLLQPPSPFQFDPVTDAIEAIARGEFVVIMDDESRENEGDIVCAAGKLTTEGMAWMIHWTSGFICVSLPPDRLQALNLPPLLPPSGKSQDPKGTAYHLTIDSNAAKHPTTTGISAHDRAHTIRLLSDPLTSEEDFTRPGHVVPLRYTTGGVSKRRGHTEATVDLCYLAGLEPAGVLCELVNPDDPAGSMAKRDDCWRFARNWGLKLISIEDLSEYVKMHGAGRIPGVDGSKRANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJF8</accession>
    <name>A0A1Y1UJF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_578075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872113.1">
        <property type="nucleotide sequence ID" value="XM_022013300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJF8"/>
    <dbReference type="FunCoup" id="A0A1Y1UJF8">
        <property type="interactions" value="889"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJF8"/>
    <dbReference type="GeneID" id="33555108"/>
    <dbReference type="InParanoid" id="A0A1Y1UJF8"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="343"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="382" mass="40846" checksum="A65A2C42E7ABC74E" modified="2017-08-30" version="1">MSIRKSPPPTTQPGPGSSVALAKRARVEDEEDEHDPTRMTLTVASSGEGQRKNALVRTIKRTSGLEAPIVALSGSHGGEITACKFDPSGRTLAACSVDRSISLWNTFPPHDNFGLLPNVHKQAVLDIGFSLDSEVIYSGGADGMLVATSLRSGERLARYSAHFGPLNSLAVTISGGRELVLTGGDDGIARVWDIGMDTKEPVAEFDDGRDCPVTAVEWSADGNQCFVGGVDNEVKVWDLRTVKVLYSLHGHTDTITSLALSPSGHYLATYSLDSALIIYDIRPFSSDPMRVYRSLTGAPAGFESCLIRVAWSKHDGGQRIAVGGGDRTVTVWDVESGKILYKLPGHKGTVTGVDLHPREPIILTGSKDANMLLGELDATDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJI8</accession>
    <name>A0A1Y1UJI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_670648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872140.1">
        <property type="nucleotide sequence ID" value="XM_022018933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJI8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJI8"/>
    <dbReference type="GeneID" id="33560742"/>
    <dbReference type="InParanoid" id="A0A1Y1UJI8"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="32372" checksum="BD984D9E381C87E3" modified="2017-08-30" version="1">MLSGGYVPSNTLSIIALVLFGLLALIYWLRFFRQGRHRYMLVLGISTTTMAIGFATRIVFAGNPTSLGIYIITILLTLLSPCGFIALNYVLLPRIASHVGAQDALFIRPRWIARIYVTSDITTFWLQACGGGLTAIQNPNIANLGHWISLAALSAQAASFASFTFLAIVFAVRVSPKYIEMVQRHSVGARDEAEGQAVTARNWKVLYFAMMWTTVGIMIRCIYRIIEYSQGYDGYIPTHEVFFYTLDSLPLFLAISVWTVIWPPSYINHAKVEAEQQTSNGNTTPSLEAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJR7</accession>
    <name>A0A1Y1UJR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRO1-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_343798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872151.1">
        <property type="nucleotide sequence ID" value="XM_022012531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJR7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJR7"/>
    <dbReference type="GeneID" id="33554339"/>
    <dbReference type="InParanoid" id="A0A1Y1UJR7"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="860" mass="94031" checksum="E685F92A55F17411" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJW2</accession>
    <name>A0A1Y1UJW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_620507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872272.1">
        <property type="nucleotide sequence ID" value="XM_022015292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJW2"/>
    <dbReference type="GeneID" id="33557100"/>
    <dbReference type="InParanoid" id="A0A1Y1UJW2"/>
    <dbReference type="OrthoDB" id="2563704at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61805" checksum="FDE646FBDE9FDC03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJY4</accession>
    <name>A0A1Y1UJY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_650382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871824.1">
        <property type="nucleotide sequence ID" value="XM_022018137.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJY4"/>
    <dbReference type="GeneID" id="33559946"/>
    <dbReference type="InParanoid" id="A0A1Y1UJY4"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="641"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="782"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1537" mass="167440" checksum="9E6FEAF23BB2979D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
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            <taxon>Cuniculitremaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
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                <person name="Magnuson J."/>
                <person name="James T.Y."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">NRRL Y-17943</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1UK30_9TREE</name>
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                <person name="Labutti K."/>
                <person name="Haridas S."/>
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                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
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                <person name="Lipzen A."/>
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                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
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                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022018822.1"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SAPS"/>
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        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
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        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
    </feature>
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            <end position="1373"/>
        </location>
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        <location>
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        </location>
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            <end position="652"/>
        </location>
    </feature>
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            <end position="743"/>
        </location>
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        <location>
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            <end position="1164"/>
        </location>
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        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
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        <location>
            <begin position="1253"/>
            <end position="1265"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1313"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1409" mass="152399" checksum="24350DF3622A35FC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK41</accession>
    <name>A0A1Y1UK41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_578223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872274.1">
        <property type="nucleotide sequence ID" value="XM_022013310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK41"/>
    <dbReference type="FunCoup" id="A0A1Y1UK41">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK41"/>
    <dbReference type="GeneID" id="33555118"/>
    <dbReference type="InParanoid" id="A0A1Y1UK41"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="28042" checksum="FDAB8EF654DB7CA8" modified="2017-08-30" version="1">MTELNLKPSAASLPQSKPIPTESVLKPWIFNYAPSPDGNDLNLLIFFHGLGDTKKSFSDLGKKLNLPGTAVLALQAPDPIPLLEHPAFSWYNTFTQFFEPLPNPNPTTVIPPLRKLIENLISPEIGWSLTSIHLFGFAQGGTTALELALDLAKRFGSVTSICAPLLASISSNLHLHTPICYFTRQDQRSAVAQKQIKNVQRTFDHVDIIQGHVGRAEDMPRGQDEWTGIMKFWGGVLVKSEGWKGGGEVFEVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK83</accession>
    <name>A0A1Y1UK83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoaB/Mog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_578648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871863.1">
        <property type="nucleotide sequence ID" value="XM_022013334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK83"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK83"/>
    <dbReference type="GeneID" id="33555142"/>
    <dbReference type="InParanoid" id="A0A1Y1UK83"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="34"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="312" mass="34076" checksum="918EC521DA69E9A7" modified="2017-08-30" version="1">MASSSTEQLSKLEKTDPASVKSPLGEGKYIQTAGCIIIGDEVLNGKTKDTNSNFFAQYCFDLGIELKRIEVIADDEEEIVEAARRMTDKYDFVVTSGGIGPTHDDITYPSLATAFSLPLEYHEETGRRMWALASPERKEQLSKATPAQKEARDRMALFPTAKGGHGSDGSGGSKSEVIFVEEDKWVPVVRLGGKLCIFPGIPSLFQQLLLGLTPYLPLPPASSKPFRHLIYTKQPESVIAPFLTELQARVKKEGIRVGSYPYLYSGVHVSLIGHDVERVKELGQEVVKELDGQVISQGRLGEGGSDEKSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKH1</accession>
    <name>A0A1Y1UKH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_365965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872470.1">
        <property type="nucleotide sequence ID" value="XM_022012591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKH1"/>
    <dbReference type="GeneID" id="33554399"/>
    <dbReference type="InParanoid" id="A0A1Y1UKH1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="31539" checksum="600AF4AF58E9E350" modified="2017-08-30" version="1">MKRQSGLTAAPKVMAVMRHSQEEKRPGVVVHEQGRTIKRARLSSSKKNPGKENGPKVKIERNDNSQSIQSKLEKGKSRAEVPNFKTTLAEQALMDDLMAGLDSSLFDDFDMTPSQKSQALVSSQTPTKPKRIPRLPLSPVKLSVRQQHITPKPVIVKHEPQSPQRDIIVKREPNLELGPEPVVDIKPLVLKTDPDEDFFDDLDFDVGDLFAVDEQKLLEGLAEQRYPISHPTVPSAPEGYRPTSWVRCIVQSVYNGLRSEEALLHSADDEYTGPSHLSGKNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKN5</accession>
    <name>A0A1Y1UKN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cyclin-dependent protein kinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_621570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872530.1">
        <property type="nucleotide sequence ID" value="XM_022015395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKN5"/>
    <dbReference type="FunCoup" id="A0A1Y1UKN5">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKN5"/>
    <dbReference type="GeneID" id="33557204"/>
    <dbReference type="InParanoid" id="A0A1Y1UKN5"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="38"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="41043" checksum="059AD4AD304A3594" modified="2017-08-30" version="1">MAQPPHPLATLAQILTTPSQKDGLPSDVEADLRVVGCMMIQEAGIMLELPQSTIATAQVLLNRFYYVSSMLSFGVNDISISALYLSSKLNETPVRLRDLINTYIFLVARINHLLSLHADQPLASPSTASSSKSASKPWGDEPEPWRIGLGNGQSTAKGKDKAEDQDGIWKGFRFEVPGFHDEVFWDWKDVIVGSEMQILKRLGFNMQVDLPYSHVINYCKILDLVFEPDVAQTCWSILNDALLTPLYAIHQPHTLACASILLSTRLLRIPLPKDWWILFDVEWDDIWSCAGTIMRLWHDWGLGPLRDAGAARGPKSRRDEPREAVHVVWEKAIPGREARWRRAWILSQGRKVVRKWVEGRDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UML5</accession>
    <name>A0A1Y1UML5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_578261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872297.1">
        <property type="nucleotide sequence ID" value="XM_022013311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UML5"/>
    <dbReference type="FunCoup" id="A0A1Y1UML5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UML5"/>
    <dbReference type="GeneID" id="33555119"/>
    <dbReference type="InParanoid" id="A0A1Y1UML5"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012688688" description="PHD-type domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="472" mass="53017" checksum="F2F586A4018DD761" modified="2017-08-30" version="1">MWHPHPLAGLSSVFFTLLDPSASTPDDSLTSLRPAVSLNRPSRARVSSPRRHHFTTSTHSHEPSPIPPHGALSIFETAPPSALPEALQEVIGSSSSSRHGDSVGTPGMDSAMTTDKDKEGDTLMREADQGFNSRLRSKRSKEEVVVKTGINASGKGVKVSGHVKEAGKPLRKKGKGRGDQDIPNQDFCSACRGTGKFLCCDGCPRSFHFMCLEPPFKIDELPQEETWYCKKCRAERVSGEAQTPAELWQSRDVASPARNRDPRPIPMVFRQLVKRVEEENPTQFRLPNDIRQFFSGVGTDGKGNYFDAEETRTKYDRKGFQEERDGTKLRDGRSKHVACYACGGTSIPLKSVTTDPGVAWRQIVSCDYCALHWHLDCLNPPLATMPNSGRKWMCPNHVDQVIARRRTLRNNLETIDVEYQGQPNNGNITILPDDQRKETFDYEDMIINKRKYRVPEKIIKLDFWNKIRQRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMP5</accession>
    <name>A0A1Y1UMP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_354509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872327.1">
        <property type="nucleotide sequence ID" value="XM_022012566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMP5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMP5"/>
    <dbReference type="GeneID" id="33554374"/>
    <dbReference type="InParanoid" id="A0A1Y1UMP5"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="345" mass="38670" checksum="808ACC036736F632" modified="2017-08-30" version="1">MDQFAMLDPFFQRLLSEQNASNDLYSSVASVYAPQDEHRELQSMLNVDNLQISDELKNAMKNITRACLTLAVQCGKQHDVLRALPGGGLKRVFPIRRLFRDPLQITFDMPWDQMMATFEFGDERSKPSSETSLNLPNSTKVHSAQRQEELSGVAAQSLSSEPHTISGHRYRQTSGSSIPISKTKASATSSEEIQRTSGLRGTDARVPRDEAKGNAPTYIVNGKQMKLIHRIFDGDDGRVGSVRWFDLDKLMKRLGFRVELRTGSIVTWIPPLGQGRPMNVHRPHPECSMGPKSTVNLAKRLMQRSSKKALRCATGVPAMELRRIRMPRTKPELPGRTDSKGDDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMT1</accession>
    <name>A0A1Y1UMT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_649437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873224.1">
        <property type="nucleotide sequence ID" value="XM_022017987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMT1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMT1"/>
    <dbReference type="GeneID" id="33559796"/>
    <dbReference type="InParanoid" id="A0A1Y1UMT1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="294" mass="32995" checksum="6BE53E9C38CD85F8" modified="2017-08-30" version="1">MSAFEPPQHQRSYSYPNPSLPPFSNLSQQTPHTINLHTPPLKKSSIMPSLDGGAASLQSAGTTTLPLLQPMDFSRYTTLYNTPTATQLAHQISHDRFQSNGNRADETPPTHHATLPSTPTEPTCASAHPTSLVESYLFAPQPKQHFAQILTWPQHHLEESREFITPSKINQGFTPLTLGNDLPLEAFPRSHTYSQPQTQGVPDYMGNMMRFEPIDEEEAAREAHLLKTRKHVCVVCNKRFNRPSSLSTHMAVHTGAKHPYTRPEARSDISVSRNIFRTHVKTSDILVMEFITFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN75</accession>
    <name>A0A1Y1UN75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_297593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872769.1">
        <property type="nucleotide sequence ID" value="XM_022012417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN75"/>
    <dbReference type="GeneID" id="33554225"/>
    <dbReference type="InParanoid" id="A0A1Y1UN75"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="142" mass="14913" checksum="9BBC1484EF4613E0" modified="2017-08-30" version="1">MTETVENAPQPEKQQAGVDTKEEGAVVATAPGEGESAGATRDPLAAVEVAKTERVIEDGTASNDGASEDEVEGLVEDGDKLSEEVESALETVDHAPQADNAQPTTEMQTDRPADSTEDDKRDETDPSSEIPTTVAQQHPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN99</accession>
    <name>A0A1Y1UN99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_641283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872860.1">
        <property type="nucleotide sequence ID" value="XM_022017414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN99"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN99"/>
    <dbReference type="GeneID" id="33559223"/>
    <dbReference type="InParanoid" id="A0A1Y1UN99"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000162">
        <property type="entry name" value="HAD-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="346" mass="36957" checksum="FDE25FDF96B9562D" modified="2017-08-30" version="1">MATSDRFPNTSSFTVDGVLFDMDGTLTDSIAAVEAAWSAKADELGLDREEVIAATHGRRASDNLQDLIPNLKKEHVDKEVDKFERSILAFADSPPVSRSGSRRNSRSGSAASSRSNSISSSRKPSFSKSATSLGTLSSFGPMTPVTGGTDSPKEATRRPSTSLSNDITKALTNLAMSSSPKKEPILIDEVDGDVFEVDEEDLVDMSVQILPGVRKLIDSLPKDKYAVATSGAKTYCHGCLERTGIAVPGVCVTADDPRLEKGKPHPDPFLLAAKDLGIDPKKSVIFEDSPSGIKAAVAAGGTVIAVCTSHKREQISHYGAHYIVETMDQVKCEQLPDGRLHFTVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNG9</accession>
    <name>A0A1Y1UNG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_614319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873393.1">
        <property type="nucleotide sequence ID" value="XM_022014584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNG9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNG9"/>
    <dbReference type="GeneID" id="33556392"/>
    <dbReference type="InParanoid" id="A0A1Y1UNG9"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="35226" checksum="90E137C09D33DC93" modified="2017-08-30" version="1">MNFLQSLSTNGPMEDEQCFETLKHAIDRAGPGEKVVINSSEHYGANAANLELLSRFFTRYPETKDKAFVVVKGGLGIFNPGSDGHISPDSSPEGLRRSAEGIAKKLHPKKVDVLGPGRLDGNHSVEEVIKTLVELQKEGLFLYIGLSEVSSSTLRKASAISQIVTVETEVSPLAWEEETRKVFAVAEETRTVILAYSPLGRGALSGKSYEEIPKHVRDLFPRFHEENWEENKKIGEKIKALAEKKGVSVGQLTLAWVSSTSPQVIPIPGTTMLYRASENFDAMDVELNSEERQEVDAVLESTTVKGGRYPDAYKKFTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNK7</accession>
    <name>A0A1Y1UNK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872909.1">
        <property type="nucleotide sequence ID" value="XM_022017940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNK7"/>
    <dbReference type="GeneID" id="33559749"/>
    <dbReference type="InParanoid" id="A0A1Y1UNK7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012530755" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="48360" checksum="3EF1BF548379B5EC" modified="2017-08-30" version="1">MELYSSLSLACLWGIAVASGRLTRRGDSFSLADTANACSQECDNQNLAGCSSSDPTEEFKCICQVAILQEYAECIECIYQTGGTLEINGTATSANQYLDAFLADCDAEGYDIVSTVFDAYTTGIYTTSPASATSTPATTAFSTTAAASAKAGNQAPSRGASPSNPVFFPPTPYNTTASSSAYDSSEGLCIVNFFTGWTPGYLNCLYDAMVLIPESSSSCQDQVCTWTESDPKLCSGLMCNQGSTIPSPMICDAIFHDASNGNSIPQVQQAGEDLDSVQLWYICNCNGPTPSVPEECAGPCGQNCQTSLSKVTSDLRCNYAAICIDGSSDNPREDDTSTCVSPLFAQTNASGVEYILYNGGVIPCSATSGPFGLDSCGTSGSSFNSGSASCSCTGKALNSDPCGLVDATNTTTQQQQGQNGPSTSATAVTAASNTTSPSPSSSSGSPAASVFGYKQVLLGLAVGAVFHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNX8</accession>
    <name>A0A1Y1UNX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_614833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873528.1">
        <property type="nucleotide sequence ID" value="XM_022014649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNX8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNX8"/>
    <dbReference type="GeneID" id="33556457"/>
    <dbReference type="InParanoid" id="A0A1Y1UNX8"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214743" evidence="2">
        <location>
            <begin position="35"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="266"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="588"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112424" checksum="1DD9351FAD8A7A84" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP17</accession>
    <name>A0A1Y1UP17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_576029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873568.1">
        <property type="nucleotide sequence ID" value="XM_022013167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP17"/>
    <dbReference type="FunCoup" id="A0A1Y1UP17">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP17"/>
    <dbReference type="GeneID" id="33554975"/>
    <dbReference type="InParanoid" id="A0A1Y1UP17"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="322" mass="36145" checksum="8AB17A71933F6854" modified="2017-08-30" version="1">MIGRLLEAGYSGKVTKSPPLKNAEIAAVCAAAREVFLSQPTLIELSPPVKIVGDVHGQYADLIRMFEMCGFPPQANYLFLGDYVDRGKQSLETILLLLCYKIKFPENFFLLRGNHECANVTRVYGFYDECKRRTNIKTWKTFIDVFNALPIASIVASKIFCVHGGLSPSLKSMDDIRRIQRPTDVPDYGLLNDLVWSDPSDTALDWEDNERGVSFCYGRSVINSFLATHDFDLVARAHMVVEDGYEFYNDRSLVTIFSAPNYCGEFDNFGAVMSVSEDLLCSFELLKPLDGAALKKEMTKSKRKSLQAHQSPPNQSYVAQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP33</accession>
    <name>A0A1Y1UP33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_615041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873588.1">
        <property type="nucleotide sequence ID" value="XM_022014676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP33"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP33"/>
    <dbReference type="GeneID" id="33556484"/>
    <dbReference type="InParanoid" id="A0A1Y1UP33"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="236"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="35754" checksum="20E459FE0EE241C6" modified="2017-08-30" version="1">MSTNQKTSAGHDAKRRKFTPRPARSAEERLPTLYRGLTDQVNDGHFQNAIKTCRKILSLDPKSQAAFQTLLFLHLQTDDYTSALDLVNATSKAQDESTLQFERAYCLYRLHREKEALSMLEKGSKGRKELHLEAQIRYRLGEYDQAQHVYDDLLAGCDSSSPEHDDIMTNISATAAHRDFHDHAYHSQLSAPRPAHTADSTLPTHVPAEGELESYVPSLPAGWAKGGSQPSKGTTSTSVPKKQDAKKEPTKKRTHRLPQGAVEGKPFTEDPDRWLPMRQRATFLAAQSKKKGNMTSMGTGITQGSSASAGGGGSGGGGGGKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP72</accession>
    <name>A0A1Y1UP72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873210.1">
        <property type="nucleotide sequence ID" value="XM_022017985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP72"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP72"/>
    <dbReference type="GeneID" id="33559794"/>
    <dbReference type="InParanoid" id="A0A1Y1UP72"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="570"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
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            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1147" mass="124019" checksum="E7F1E8471B270B66" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP75</accession>
    <name>A0A1Y1UP75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_615179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873616.1">
        <property type="nucleotide sequence ID" value="XM_022014688.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1UP75">
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    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP75"/>
    <dbReference type="GeneID" id="33556496"/>
    <dbReference type="InParanoid" id="A0A1Y1UP75"/>
    <dbReference type="OrthoDB" id="2578710at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16031">
        <property type="entry name" value="G6S_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
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        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="63355" checksum="36767C0C47970E22" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPH1</accession>
    <name>A0A1Y1UPH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_678956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873657.1">
        <property type="nucleotide sequence ID" value="XM_022019021.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPH1"/>
    <dbReference type="GeneID" id="33560830"/>
    <dbReference type="InParanoid" id="A0A1Y1UPH1"/>
    <dbReference type="OrthoDB" id="2589068at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
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        <location>
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            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
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        <location>
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            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
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        <location>
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            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1155"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1307" mass="143733" checksum="B9D0A72D56DA7610" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPP1</accession>
    <name>A0A1Y1UPP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872968.1">
        <property type="nucleotide sequence ID" value="XM_022017949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPP1"/>
    <dbReference type="FunCoup" id="A0A1Y1UPP1">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPP1"/>
    <dbReference type="GeneID" id="33559758"/>
    <dbReference type="InParanoid" id="A0A1Y1UPP1"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="431"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1152" mass="119689" checksum="670D216BDEA9B127" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ60</accession>
    <name>A0A1Y1UQ60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_262764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873948.1">
        <property type="nucleotide sequence ID" value="XM_022012317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ60"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ60"/>
    <dbReference type="GeneID" id="33554125"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ60"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="524" mass="57936" checksum="958827061173A1A1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQH6</accession>
    <name>A0A1Y1UQH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative longevity-assurance protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_648338</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873491.1">
        <property type="nucleotide sequence ID" value="XM_022017825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQH6"/>
    <dbReference type="FunCoup" id="A0A1Y1UQH6">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQH6"/>
    <dbReference type="GeneID" id="33559634"/>
    <dbReference type="InParanoid" id="A0A1Y1UQH6"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="113"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="394" mass="44851" checksum="5A3540132E48870B" modified="2017-08-30" version="1">MASSMTLPNLYDNFLSTLPPQLHPFFQLSYAVNQSTPFSFGSSFLPSSSSSSLVAPETLYDKGIMDLCITISCAFGFTILRNLSMEYIFSAFARYWLMPSRELNKLEKKAIQHSVTRFAEQSWSLTYCTVFWSLGMVILMQLKAPLSPESLWGSYPVRYLPGLTKFYYLAQLGWWLHQIYVINSEQRRSDHWQMLTHHVLSISLICGSYVANFSRVGVLIHALMDFCDILLPLAKLFRYLSFSTLCDVTFVAFLIGWLVSRQIGLAFVIYTSYVDAPKFIKFRWSPQTGQYLTQTTYYGFIGMEVFLYGLASIWFYMACMVAVRVVTGQGAADSRSDAGDEDEEERNGAFPDEKSPEGQQGLDVELVEATEHDAIMMAESKGPSEVPEKLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQK2</accession>
    <name>A0A1Y1UQK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_614903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873549.1">
        <property type="nucleotide sequence ID" value="XM_022014661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQK2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQK2"/>
    <dbReference type="GeneID" id="33556469"/>
    <dbReference type="InParanoid" id="A0A1Y1UQK2"/>
    <dbReference type="OrthoDB" id="2584073at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="482" mass="52761" checksum="EAD45AC2D122BBD0" modified="2017-08-30" version="1">MPRLHVGLISSPCLAGPSRLSRASSKSALNREAPNRDPRRNASTSSTSTTQDADWRSWLKRASSFNMIQDGSGKGKALLFAGLGSYPHTPYSPTQSSLQIWESASEALLNPDATIGYWPKGMEEFADALRGGIGIRGWLRGWVEGRSLDELMRRADVTAAFILTSSIAILASAQETAGSSSLLPRGTMYLAGHGFIGTLTALVAADRLDLPTGVRLAMMYASLSPSPSSLPHLKPKFLSTVMSARQFHSLSGPSYTVPHVNSDEDAESPDSSAERKRAMQLILDEVHGMQKGWWDKGGEEWAAPAIINSSKILVLSGTQMAVLDAIERLEVMGLANPVIDIPQPCPYHTRLMEHAIPKFRETLSLCHFRDPDPHDAQMHAGTVGPIILDPMATHPMGSIRSSLLPHLTEQLRWHKTLSRLYKYPSTDIDTFHTIGRGARGLGIMLRGEIKRRYKGAEEIKVEEFGVKPGESDREKLIRKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR82</accession>
    <name>A0A1Y1UR82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_610766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874131.1">
        <property type="nucleotide sequence ID" value="XM_022014219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR82"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR82"/>
    <dbReference type="GeneID" id="33556027"/>
    <dbReference type="InParanoid" id="A0A1Y1UR82"/>
    <dbReference type="OrthoDB" id="2576482at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="540" mass="62102" checksum="161E4061DA580E34" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URA4</accession>
    <name>A0A1Y1URA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_648593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873761.1">
        <property type="nucleotide sequence ID" value="XM_022017862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URA4"/>
    <dbReference type="FunCoup" id="A0A1Y1URA4">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URA4"/>
    <dbReference type="GeneID" id="33559671"/>
    <dbReference type="InParanoid" id="A0A1Y1URA4"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="50"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="589"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="890" mass="97225" checksum="209D5DAD3A6944D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URN6</accession>
    <name>A0A1Y1URN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thimet oligopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_575927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873949.1">
        <property type="nucleotide sequence ID" value="XM_022013156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URN6"/>
    <dbReference type="STRING" id="4999.A0A1Y1URN6"/>
    <dbReference type="GeneID" id="33554964"/>
    <dbReference type="InParanoid" id="A0A1Y1URN6"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="210"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="646" mass="73604" checksum="1140025527A84C37" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URR8</accession>
    <name>A0A1Y1URR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_616733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873979.1">
        <property type="nucleotide sequence ID" value="XM_022014854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URR8"/>
    <dbReference type="STRING" id="4999.A0A1Y1URR8"/>
    <dbReference type="GeneID" id="33556662"/>
    <dbReference type="InParanoid" id="A0A1Y1URR8"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="62"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="30870" checksum="0B96AEB62E81FD73" modified="2017-08-30" version="1">MSDPNDAWRTDAPSGGDGYGSPRREDTNGRSPRRDRDRSRSPARNGDAERPTRESDAANTGSNLHVSGLSRSVDVPMLESLFSKHGKVESASVMLDPHTQESRGFGFVKMTTAEEAEAAIAALNGMNFEGKSLTIAHARRGRARTPTPGRYHGVKVDIGPRGGYGYQDRPYQPRSYDSRYADRGPPPRDYYDRRDYDRRDYGGRRDDYYDRPRGDYGRRDDYDRRDRYDDYSRGPPPRAGGGDPYYRSERPDARRDDRVPPRGGYDERPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URU5</accession>
    <name>A0A1Y1URU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_15952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874368.1">
        <property type="nucleotide sequence ID" value="XM_022012055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URU5"/>
    <dbReference type="GeneID" id="33553863"/>
    <dbReference type="InParanoid" id="A0A1Y1URU5"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="534" mass="58470" checksum="928D42F7C890E188" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US61</accession>
    <name>A0A1Y1US61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Peptidase family M41-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_612188</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874498.1">
        <property type="nucleotide sequence ID" value="XM_022014366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US61"/>
    <dbReference type="FunCoup" id="A0A1Y1US61">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US61"/>
    <dbReference type="GeneID" id="33556174"/>
    <dbReference type="InParanoid" id="A0A1Y1US61"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="341"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="169"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX40819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="767" mass="82916" checksum="7A4A5ED270060B0E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USL2</accession>
    <name>A0A1Y1USL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_606669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874621.1">
        <property type="nucleotide sequence ID" value="XM_022014024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USL2"/>
    <dbReference type="GeneID" id="33555832"/>
    <dbReference type="InParanoid" id="A0A1Y1USL2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="473" mass="52821" checksum="29DE5F7A251D5D66" modified="2017-08-30" version="1">MNQDINTETRKESLPFIHPDRAKLITARWPTDTTVGDEVKGQTADNTYEAGPFSRASQSGIDRLHETYLAAWTNALKAKLRAHDVLKSEMGTRRDLWPSFESNVRRLGMEKVRVGDDLSVRWIVQHDLAEDLISGKTQATCDVSFTEPPESQEEAQKVIISNSERSFSLTSTWQPWPTGDPFGTSDPSKRWMENPKFNRTRVRLYKAWSKTLGALVDDKCPLETGTGILEAAVPHRLALWSAIKTWLSEEDIVGPDCHVSATKSLVSCRHKLATDGNTILSSTKQLIEQRDVTGQGRNERFDRPEASDAVSVESGDVGDPRDVLLDGETELCFTDLQSSLRRNNDVGDVLEPIWADSELGLQARHGVVEGTLSAVHQELLHDIQQVFPPTDDWEDLELSAIIELTHKVTQDSDDGYTQCTIETGSVGHAELDTDGFTYQGSWTWRTSDGHILGHDVTVVTGRLRPPKLEPRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USN8</accession>
    <name>A0A1Y1USN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucocerebrosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_574636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874712.1">
        <property type="nucleotide sequence ID" value="XM_022013075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USN8"/>
    <dbReference type="STRING" id="4999.A0A1Y1USN8"/>
    <dbReference type="GeneID" id="33554883"/>
    <dbReference type="InParanoid" id="A0A1Y1USN8"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="588"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX41033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="751" mass="85067" checksum="5C3D15787BD6DCF8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USQ1</accession>
    <name>A0A1Y1USQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874718.1">
        <property type="nucleotide sequence ID" value="XM_022017744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USQ1"/>
    <dbReference type="STRING" id="4999.A0A1Y1USQ1"/>
    <dbReference type="GeneID" id="33559553"/>
    <dbReference type="InParanoid" id="A0A1Y1USQ1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372">
        <property type="entry name" value="DAUER UP-REGULATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47372:SF11">
        <property type="entry name" value="RE19971P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30292" checksum="E3040E1B8DF9FF02" modified="2017-08-30" version="1">MSLRSASRLARSLRVAPRPSVTLQPLARRPNSSSSHGQPKGNDRMWQVGALLGWGAITAWIFQHYQNRAHHGHGHGHDSHGHEEHEEVEESSEEDSSSAEGVAAAAKGLKDKAEDATEDAKEKASGLAKDVKSKASELTEDAKSKASEATEAVKAKASEAKESLWSRAFKAKENVKDKASEAKEAVEDKASEAKDKADEATEHVKDKAAEAKENVKDKAAEAKENVKDKASEVADAAKSKAKEVKDKAEDEAGVSAQDIKDSLNRAEKSNVPRAAMAAEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USX1</accession>
    <name>A0A1Y1USX1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874787.1">
        <property type="nucleotide sequence ID" value="XM_022014478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USX1"/>
    <dbReference type="GeneID" id="33556286"/>
    <dbReference type="InParanoid" id="A0A1Y1USX1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="162" mass="18022" checksum="5D994327FB3E8D0A" modified="2017-08-30" version="1">MTEYSCPRTHSLSGPTSDSPTVQTRTDVNLDSHVRKLVQAILTTPEFQSRFCPGTASDAFRRETTDSTVRNVSGLAGNSRFHFEDYLPDSAFEGSQEAQTLAVISALSPANGSVRRMARRWSMAGTHDSQSRSRATVSYALDSTPQRKTVRFSDSWVRRTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT09</accession>
    <name>A0A1Y1UT09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_612053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874446.1">
        <property type="nucleotide sequence ID" value="XM_022014339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT09"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT09"/>
    <dbReference type="GeneID" id="33556147"/>
    <dbReference type="InParanoid" id="A0A1Y1UT09"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48716" checksum="89B2187DEE41F398" modified="2017-08-30" version="1">MAVVFRSTSDLLYLPDHGFVEEDGAIKILLQINRQIRRLDVSHNLLGNEGISVLIQGLNSCRHRFSSTDYGLWGLRDINLGSNSISDESFSALMSYAKKDVFMRRVTVQGNDIELRNHLDSVLNSLNSSHIEDLSLTNNPSLLSSSIRKLFNTITTPYLSQLYLSVCNLGPNIIPPLVSYLGSPRSRNLELLELNGNKLGVEGVRAIVDVVESFNFTIKEVSLLANDVLSRSNDDVEETSRPSDAEKRAENDALAYECHRRLPPLLARNRALTQRIRRAAIRVIAPARILLTARPLNDVEMARQVIDSIGTRPPAFRILDLPREVLYLIVRHCSRDASAFSEAQFTRMRKEAESRDNVKRNGTIMRERLLKAESDQIGRAVWQVREEWLKKGKWDKWELDKPVQVPAHTETVESHSGKSSDLSPGTQSLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT44</accession>
    <name>A0A1Y1UT44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_47206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874860.1">
        <property type="nucleotide sequence ID" value="XM_022012880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT44"/>
    <dbReference type="GeneID" id="33554688"/>
    <dbReference type="InParanoid" id="A0A1Y1UT44"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="164" mass="18426" checksum="D93CA1FD351CC80F" modified="2017-08-30" version="1">MQAANIVETPEELKNQATRSQYQQSCRWFHHSPRQTRPLRGMLTTRWATVDTPPRAPTGQGEKSISANSSYRKREQRSRCQPREHVPAWYCTGIVPAAFSAEVSPSSNRGGFGSDDVAVSYWALSYAIHVACNDSRSAAWLEFRIQIQTAHRPKVMIGTCGCQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT71</accession>
    <name>A0A1Y1UT71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_585895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874496.1">
        <property type="nucleotide sequence ID" value="XM_022013740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT71"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT71"/>
    <dbReference type="GeneID" id="33555548"/>
    <dbReference type="InParanoid" id="A0A1Y1UT71"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="28221" checksum="40003A7D16E19300" modified="2017-08-30" version="1">MSDEGKLADTPQIPALDLFSLRGQVALVTGGSRGIGAAMTIALAQAGADVVSAQRDTSNTSTRDAIRALGRKCEIIGCDLTDKESVKTVVQRAVDAMGNIDILINCGGMLKRQDTVDITSADWNEVIDTNLTALFTICQEAGKHMIPRRRGKIINVSSLNAFIGGARVIHYTAAKTAVMGLTKALSNEWAKYNIHVNAIAPGSIATDINTEARKDPAFVKNRLVGTPGNRWGAPEDFAGPAVFLASAASNYVSGETLVVDGGALGKGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTD6</accession>
    <name>A0A1Y1UTD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylyltransferase family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_575234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874891.1">
        <property type="nucleotide sequence ID" value="XM_022013114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTD6"/>
    <dbReference type="FunCoup" id="A0A1Y1UTD6">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTD6"/>
    <dbReference type="GeneID" id="33554922"/>
    <dbReference type="InParanoid" id="A0A1Y1UTD6"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="36684" checksum="BD5DEB81B7BF0CD1" modified="2017-08-30" version="1">MGNGGGRTWRDGSLEIEDDAIRARKSHSVRSSKSPVPSSPGSPAYNGLPTLPTIPDPDEDTGDAIPSSSSITSRPPPPAASTQTASGRPLQRKRRSSSIKRKPSPGVTPKNVVDWEIPRKTLHSSIGFLTLGLYYLDPKDLTLLLTVLSTGLISVFTIDLARLRFPVFAEHWESIVGFLMREQERSRINGVVWYLMGVITVLAVYPRDVAVISILTLSWSDTTASTIGRLWGKYTPPLPSHFPGVQQLRFAPRKSLAGFLAATVTGILICLGFWWHGSQGRWLLLDGTWPGLLSTAVIVGIGGAIAEAMDLGLDDNLTLPIISGAMAWAWLGATNLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE9</accession>
    <name>A0A1Y1UTE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_51558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874911.1">
        <property type="nucleotide sequence ID" value="XM_022012976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTE9"/>
    <dbReference type="GeneID" id="33554784"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE9"/>
    <dbReference type="OrthoDB" id="2562172at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="177" mass="20932" checksum="C440DE2631A989E2" modified="2017-08-30" version="1">MLLGDGYLKVDPYFRLFWASATDTENVQFMNTIHPPGPSYPTFDNTTPFELYPTLVHHTVTGEVPVAVHLNDYWHKHYIEEWYGRLWWTSERKRFWPIVRERMEKGTIKFATEEGITEESARSVCPNLPIWKKEIPIHSKRSFGCRVRSQQLPRRSPWLCSMDSDSIHRSQRPILPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTF5</accession>
    <name>A0A1Y1UTF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_648180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874988.1">
        <property type="nucleotide sequence ID" value="XM_022017801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTF5"/>
    <dbReference type="GeneID" id="33559610"/>
    <dbReference type="InParanoid" id="A0A1Y1UTF5"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="54" mass="6230" checksum="0C882007E030529C" modified="2017-08-30" version="1">MREREMNAVDWGHDMIAACTDDAATRIWRRDDVTALKLKNEPESMTQEWAGHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTK3</accession>
    <name>A0A1Y1UTK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_575242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874616.1">
        <property type="nucleotide sequence ID" value="XM_022013115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTK3"/>
    <dbReference type="FunCoup" id="A0A1Y1UTK3">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTK3"/>
    <dbReference type="GeneID" id="33554923"/>
    <dbReference type="InParanoid" id="A0A1Y1UTK3"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX40937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="280" mass="31612" checksum="45B922AF467BB346" modified="2017-08-30" version="1">MNFTTGAKASELLSLDHIRSQLIRLEDTIIFSLIERAQFARNAKIYEKGAFRDIIDFDGSWVEWFLLETEIFHAKARRFTSPDEFPFTPLERLPQPVIPVMTFPRLLYPPAASKVRVNDQILRFYCGEIVPGITSAADDGNYGSAATRDVEVLQALSRRIHFGMFVAESKFLSAPHDFIPHILSTPPNGDALAGLITKPEVEAKLLVRLGNKAKIYGGEFDADGKIIETSGMGKIDVQKIVDMYRDHVIPLTKVVEVEYLVHRLDDVPQSQIDAWMQSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTS5</accession>
    <name>A0A1Y1UTS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tubulin binding cofactor C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_33860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874696.1">
        <property type="nucleotide sequence ID" value="XM_022012521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTS5"/>
    <dbReference type="FunCoup" id="A0A1Y1UTS5">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTS5"/>
    <dbReference type="GeneID" id="33554329"/>
    <dbReference type="InParanoid" id="A0A1Y1UTS5"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="171"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="350" mass="38027" checksum="3774809026675FE1" modified="2017-08-30" version="1">MASISTSAEFHQTFQAGKSGIVSLLDAPGPQFSEVTQMMTELKSQLAEVRSSLPPYDQRNYELQLRELENRISTLRAKSRPKTKFSFANKGILSSNQAGTIASSGTTVPKDLTDQSTATQPQQDISRDISPSSLPALGESIPLPTAGPSSIHRTITHRQNARIDLSALELPDSSIDSDNGLKGGWTLSLEHLEDCTIDLRPDSNTGTNTSTMYTGDGAQSTGLSSLHARNLDRCTLIIGEMNGSAMLHDLKDCKIFASLQQFRIHTSTRCDISLYIPSVPIIEACSHLTFRPLDTHCSDRDLSPDPGSDAGGRIRLSNRVHEVADFSWVKPSTSPNWIYVDQPISEGDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUD4</accession>
    <name>A0A1Y1UUD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_612157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874484.1">
        <property type="nucleotide sequence ID" value="XM_022014362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUD4"/>
    <dbReference type="GeneID" id="33556170"/>
    <dbReference type="InParanoid" id="A0A1Y1UUD4"/>
    <dbReference type="OrthoDB" id="2595387at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="110" mass="12130" checksum="B67AC9E44D400AF9" modified="2017-08-30" version="1">MVNSVNGPRAIRHIRNPFGHQDEGIRIVWPDQGENGDREMADWPRRDALLSQGRRVRATEGDVYSLSALDDPFASHLGPRPATGECQGGVGGMWPLVPRMSTVDITMGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUQ0</accession>
    <name>A0A1Y1UUQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_648175</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874983.1">
        <property type="nucleotide sequence ID" value="XM_022017799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUQ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUQ0"/>
    <dbReference type="GeneID" id="33559608"/>
    <dbReference type="InParanoid" id="A0A1Y1UUQ0"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX41304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="86" mass="9483" checksum="55D8405D5CFE3F0F" modified="2017-08-30" version="1">MSNALGLNGGNPRCWAHLMEFQRCWKSAQEPQECKPQHEDYIECLHRKKEQASSAKEAAEKAAAGTIISLGLVEDPTAGGKDEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6C4</accession>
    <name>A0A1Y1U6C4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_216037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867898.1">
        <property type="nucleotide sequence ID" value="XM_022012199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6C4"/>
    <dbReference type="GeneID" id="33554007"/>
    <dbReference type="InParanoid" id="A0A1Y1U6C4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="41926" checksum="F5537D508C576C10" modified="2017-08-30" version="1">MYNAYSVSDVKNPSDVRTFYTNSCIPSVIHQGRPLYDDLILSPEVSYRVESYIGPAMLHTMSTNDGTNTMMRTDDDQFIRPICPTVVDSVKVVNGSNWGTNQWLSALLEGPPPNPPPPGADWRKYNSAPTNTSRKTNTMVRDTSVASSKPGIIKPQGSRPEYGTSTAASSQPGSMPIGPGKVRSTPGTSNSMAPNRGWHNVSKGSSMPPNVEFAPTRFAPNHISTQGGPPPGLGGTSMGSGKSVKYASQPSQPSLASGPSTYQASQTYSASRPPPPPPPPPASTAGFCSSLGNQSAHAYQSAQAPYPPREWIIQPTGSKYEDSPTLPPDGADKYQGTTMSSVPIHATYNPGHESRSAIKSGRMNMYTPETSLSSSPVDVGVLSRPSSAGCDHWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6V9</accession>
    <name>A0A1Y1U6V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868047.1">
        <property type="nucleotide sequence ID" value="XM_022017112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6V9"/>
    <dbReference type="GeneID" id="33558921"/>
    <dbReference type="InParanoid" id="A0A1Y1U6V9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="60" mass="6413" checksum="D0DDB65200FD35C0" modified="2017-08-30" version="1">MDEQGYARTRLIFFFGLLFFFQAFAPWNGSYSEPLIQGLLGCWAAAPAAAAAACIGCGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7A1</accession>
    <name>A0A1Y1U7A1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug resistance protein fnx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_640011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867742.1">
        <property type="nucleotide sequence ID" value="XM_022017309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7A1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7A1"/>
    <dbReference type="GeneID" id="33559118"/>
    <dbReference type="InParanoid" id="A0A1Y1U7A1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="87"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="597" mass="63803" checksum="34139A18DE62F643" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7A6</accession>
    <name>A0A1Y1U7A6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_181550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868176.1">
        <property type="nucleotide sequence ID" value="XM_022012111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7A6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7A6"/>
    <dbReference type="GeneID" id="33553919"/>
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    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25955" checksum="FFC1489C159505CC" modified="2017-08-30" version="1">MRRVAVIIGAGPGTGAAIAQRFSATHSILVLSRSLPGSLPKLNLDTPSDRLLAATSDGSNESLKKAFELLSAHWPNSTIDVGVYNTNFSFSPGPFLERTEDQLRTNLESGIVSAFNFSQHIIPHFLANEPNETTRARGTLIFTGATMALRGGAPFSTMAPAMFARRALTQSLAREFGPKGVHVVHAIIDGKIAPPKDSGREMPSEAIDSNDIAQNYLDLVNQRATAWTQELDIRPSDESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7R3</accession>
    <name>A0A1Y1U7R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_639425</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867903.1">
        <property type="nucleotide sequence ID" value="XM_022017229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7R3"/>
    <dbReference type="FunCoup" id="A0A1Y1U7R3">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7R3"/>
    <dbReference type="GeneID" id="33559038"/>
    <dbReference type="InParanoid" id="A0A1Y1U7R3"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="14">
        <location>
            <begin position="434"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="439"/>
            <end position="441"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="439"/>
            <end position="441"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="673"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="765" mass="85289" checksum="8CFE870097F03795" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8I0</accession>
    <name>A0A1Y1U8I0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_637552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868600.1">
        <property type="nucleotide sequence ID" value="XM_022017020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8I0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8I0"/>
    <dbReference type="GeneID" id="33558829"/>
    <dbReference type="InParanoid" id="A0A1Y1U8I0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="36425" checksum="2494FEE87CC28903" modified="2017-08-30" version="1">MTVYSDQATEDETMTEKPPSMEDDSPVQTRQFLRSICVSRIALAICLPICLAVQVLHLKKNLIGGVMLVADAVGLACVVCAMIAHILSMKPRIERLQRHRIYCYLVFIAILVALILQPIIIAIRVLTTHKALPVERIDIARYAVLSITLIIGGSLRRGPKMCHEAEDRANVFDWSGSSILSFIGLFYVWPLVTRSWRADQLRPTDLPHLEQTMRQSGLREMLEDTVTGTWTERTLLYAAWKGKISIIISCELVRLAELTLALLLDALRTVASFVQIYSMHEIIDSFQNSAEHDRKYKQLMCVGLFLGSTAEVLLASYLSYVSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8J9</accession>
    <name>A0A1Y1U8J9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAP42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_635546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868616.1">
        <property type="nucleotide sequence ID" value="XM_022016817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8J9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8J9">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8J9"/>
    <dbReference type="GeneID" id="33558626"/>
    <dbReference type="InParanoid" id="A0A1Y1U8J9"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="386" mass="41968" checksum="29B5B41EC46E7636" modified="2017-08-30" version="1">MSQTDLPLPVFYSKTLSSLLPIFDDSLSLSDPNAVAILSKALEDLHLIARMITSLGVFSDNESVEELGNGELVFMSLGWVIGEAESKGGLGGIQDRLAALKRADHAFNLFLSLLSTYSIVTPSEQAESSAMGVEAGLPRDPAKRREAKIAQYKREKQLREQISTRCPGQPDSSSNPLSFILSLLPSSDSRPSSTAVNAEEDDQRTVSLSVLQLLYTLTLSSLASIKMELDILASAPPEPTSSQPPQTGETDNTWRLDRTPASHVKPRQLISGGGRVLRPFTILPSTIAMSDRERLRSEVFRSGHRLPTMTIDEYLEEEQARGNIITGGGQASADAPTESELLQLAAEEDGTMEGDAKAEQKRLKDENWAQYAEANPRGAGNRMNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8S9</accession>
    <name>A0A1Y1U8S9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24, structural domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_566291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868691.1">
        <property type="nucleotide sequence ID" value="XM_022013037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8S9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8S9">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8S9"/>
    <dbReference type="GeneID" id="33554845"/>
    <dbReference type="InParanoid" id="A0A1Y1U8S9"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="30"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="42730" checksum="D71179A0DA4B052E" modified="2017-08-30" version="1" fragment="single">PAVDLKKPAPAAEEAKVEEKGLSDDAITKYTSAGQAVGEVLKKFLPSIAPGKKVLELCIEGDKLINETVAPLWNKSKNGVKVSKGEQNPIGSLLTTLGIAFPTSISVNNVVAHVSPLPSDPEIELKENDVVKVMLGVQLDGFAVTHAETLHLTSKAPTSDSAADVIKAAYDAAQIAMRTIKAGAKNWDVTEVVEKVAKEYGCVGVEGMLSCQHEKNVTDGKKRILLNPTPELKREHETCTFEEGEVYGVDVLVVTGTDGKAKPDPSRTSIYKRANDINYQLKMKTSRAVFSEIQKKAGAFPFTLRSLEDEKRARMGVQEAVTHGLLRPYDIVQTAPGTLVAEFFFTIALLPAGPLLLSPTPAWYSADKVSSSKSLTDETLKPLLTQPLRASKKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U928</accession>
    <name>A0A1Y1U928_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_584102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868332.1">
        <property type="nucleotide sequence ID" value="XM_022013656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U928"/>
    <dbReference type="FunCoup" id="A0A1Y1U928">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U928"/>
    <dbReference type="GeneID" id="33555464"/>
    <dbReference type="InParanoid" id="A0A1Y1U928"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="226" mass="25417" checksum="E00BD39D03947AFD" modified="2017-08-30" version="1">MSISQASKNLVSVASNAGPSRSLERPREAASEHRENPPTPLRAITSASGFVFPAIWSFPPFFTLQPNPSTLSHQLTLWTNLVLSWAAHERMFMLNCDSPEPGQVFHNKSIKRKLLPGSMRTLLSHMAQEGHAALDPPKQSPPTTYLIYWRKPDEWGQMIYDWVMDHGLATSIMTFYEITDGDMSETTDFREMPVPLLRKSLETLVKKGRAQIIRGEGDSGDGARFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9B8</accession>
    <name>A0A1Y1U9B8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_123476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868872.1">
        <property type="nucleotide sequence ID" value="XM_022011966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9B8"/>
    <dbReference type="GeneID" id="33553774"/>
    <dbReference type="InParanoid" id="A0A1Y1U9B8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="103" mass="11238" checksum="8730380282CCB92E" modified="2017-08-30" version="1">MLPSHVALRFAPSSRAGGGWIFPTSWPQDKYSPLSTVKSSNRTTCIHCTMQAMTIRVSAKCASATNSSYLNSCQLVGLPKCHLSTPIPIWRPLDLKSLSVTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9G8</accession>
    <name>A0A1Y1U9G8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_126844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868921.1">
        <property type="nucleotide sequence ID" value="XM_022011974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9G8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9G8"/>
    <dbReference type="GeneID" id="33553782"/>
    <dbReference type="InParanoid" id="A0A1Y1U9G8"/>
    <dbReference type="OrthoDB" id="2561691at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="264" mass="29600" checksum="8730B9456C67A2BE" modified="2017-08-30" version="1">MNPSPVVTNIRGRAQVDQKTVHPEYNDSNADLSLVSNDNVVIHVHSFYLKAHSNTFRELLTDIMIVNADQLQMNRSPIPLDASSIAVQLFLDFMDLNKTRHIVDIDHIAQTLQLCQQFECSFLFNHILGYMADPAEAGLWIAPWKVFCIAARFDHLGLAKAAIGQMDYEQGSPPQGRWDIEGMTAAFAEDCNMRYLLGFLRVTTAHCKPAQKAKQSGKRSYDYDWDAAAKDFRVERTPVKRAKIKCVARSQRGAASATNEAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9I6</accession>
    <name>A0A1Y1U9I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CEF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-splicing factor cef1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_127127</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868935.1">
        <property type="nucleotide sequence ID" value="XM_022011977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9I6"/>
    <dbReference type="FunCoup" id="A0A1Y1U9I6">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9I6"/>
    <dbReference type="GeneID" id="33553785"/>
    <dbReference type="InParanoid" id="A0A1Y1U9I6"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="12">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="759"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="827" mass="92089" checksum="BB564A486BB79475" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9M4</accession>
    <name>A0A1Y1U9M4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_637092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868484.1">
        <property type="nucleotide sequence ID" value="XM_022016970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9M4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9M4"/>
    <dbReference type="GeneID" id="33558779"/>
    <dbReference type="InParanoid" id="A0A1Y1U9M4"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="46602" checksum="7336A9D03080F4D7" modified="2017-08-30" version="1">MSSQPLLPSNHPEHIASVIASKRRILFTTILTTVLLIAGIIFVSVKGEGVPSSKDPLKLANYYLKSSPVIDGHIDLPIFARAGFGNNIDNMDLYGDLKNRYGLISHLNIPKARKGHLGGFFWSIYIDCPKDAGPDFLTPYNGPRDTLEQIDVAMNLMDKYSDVFQLCKTADEVMEAVASGKIASLMGMEGAHSLGNSLGALRMFHALGVRYMTLTHGCNNAFADSGGIFQPVTPHWGGLSDLGKDLIFEMNRLGVFIDLSHVSDQTALDALSITRAPVILSHSCARAFNNISRNVPDEVLSKLGRGKHKVDGVVMVNFLPTFAAPGGVGVDVKTIADHVEYIASKTSRDHVGIGSDFDGIDAVPRGLEDVSMYPNLFAELITRGWKQDELAGLAGGNLLRAMRGMEATSLKMKQEGKKPSMAVYAKRTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9R4</accession>
    <name>A0A1Y1U9R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BD324DRAFT_634881</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869011.1">
        <property type="nucleotide sequence ID" value="XM_022016770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9R4"/>
    <dbReference type="FunCoup" id="A0A1Y1U9R4">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9R4"/>
    <dbReference type="GeneID" id="33558579"/>
    <dbReference type="InParanoid" id="A0A1Y1U9R4"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.730:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="24">
        <location>
            <begin position="195"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="23">
        <location>
            <begin position="494"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="25">
        <location>
            <begin position="962"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ORX34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118607" checksum="7C34031280523ED1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9R6</accession>
    <name>A0A1Y1U9R6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_584572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868124.1">
        <property type="nucleotide sequence ID" value="XM_022013689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9R6"/>
    <dbReference type="FunCoup" id="A0A1Y1U9R6">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9R6"/>
    <dbReference type="GeneID" id="33555497"/>
    <dbReference type="InParanoid" id="A0A1Y1U9R6"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="40"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="247" mass="27532" checksum="01EAA68BD661E119" modified="2017-08-30" version="1">MRATLVTLKKSASSTRWLARQANDPYVKGRIGADAGGVTYRSRSSFKLISLLDKRFPKVIVDLGAAPGGWSQVIRRKARPQDLVFALDILDMEPLKGVEVLKGDFLEQAIQKRLRARIMEGIYGGALVHPDHRDHRMVDLVLSDMMGPMTGNKLADVRTSLDLVEAASAFAFANLKEAPRVGKGDPRSTGGHLVIKFFMHPDMVEFQKQVLEPRFRKVAVPKPKESRKESSEAYFVCLGYKGDPNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9U2</accession>
    <name>A0A1Y1U9U2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Asparagine synthase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_604300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869024.1">
        <property type="nucleotide sequence ID" value="XM_022013978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9U2"/>
    <dbReference type="FunCoup" id="A0A1Y1U9U2">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9U2"/>
    <dbReference type="GeneID" id="33555786"/>
    <dbReference type="InParanoid" id="A0A1Y1U9U2"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="5">
        <location>
            <begin position="216"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="5">
        <location>
            <begin position="386"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="493" mass="54833" checksum="F8F5137E1B5E14DF" modified="2017-08-30" version="1">MCGISLSLRLVPHHSSSSVQDHLSKSLEAPIKARGPDSYQTFQTRIPLDSQWDVELTLSVSVLSLRGTGTVRQPVVTHRGVLAWNGQIFQGVHVGKEDNDTAKLAELIDSTDVDDPRALLPHIEGPYAFVFFDTKTQTLFFQVDPLSRRSLLIHPIDHNAPMQTFMLSSTRVESLSRLQDDPRVSDDNESHVADFLQRLASSVRRRIENIPNPRSGDARVAVLFSGGVDCSLLAALIHRFIPADEPIDLLNVAFAQLPDAKSVDLPRFDVPDRLSGRQSLGELRAACPRRQWRFVEINVSQKECEEHRSAVMDLMYPNATEMDLSLAYPLYFASRGQGHAQAEAYEPYSTAAKVYISGLGADEQLAGYARHRGAFQRDGIGGLLDELQKDLDRLPTRNLARDDRLISSHGRESRYPYLDLSFVTYLSSLPLSIKCDLSREGGDKALLRAAAAKCGLTETSQRIKRAMQFGTRSAKMSGQDKPRAKRGQQLANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9W0</accession>
    <name>A0A1Y1U9W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-glucoside:hydrogen symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_635078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869044.1">
        <property type="nucleotide sequence ID" value="XM_022016781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9W0"/>
    <dbReference type="GeneID" id="33558590"/>
    <dbReference type="InParanoid" id="A0A1Y1U9W0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="62"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="536" mass="60542" checksum="29527C64E83AA20A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Y8</accession>
    <name>A0A1Y1U9Y8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ribosome biogenesis and assembly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_683320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868627.1">
        <property type="nucleotide sequence ID" value="XM_022019180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Y8"/>
    <dbReference type="FunCoup" id="A0A1Y1U9Y8">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9Y8"/>
    <dbReference type="GeneID" id="33560989"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Y8"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="87"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="801" mass="88872" checksum="26E28252EC19231D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Z3</accession>
    <name>A0A1Y1U9Z3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">K, P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_657714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869091.1">
        <property type="nucleotide sequence ID" value="XM_022018869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Z3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Z3"/>
    <dbReference type="GeneID" id="33560678"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Z3"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="931"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="970"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115184" checksum="D6D3B43A3D38496A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA32</accession>
    <name>A0A1Y1UA32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_635579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868629.1">
        <property type="nucleotide sequence ID" value="XM_022016824.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UA32">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA32"/>
    <dbReference type="GeneID" id="33558633"/>
    <dbReference type="InParanoid" id="A0A1Y1UA32"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="90"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1279"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1031"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1612" mass="180078" checksum="1AC78C2E3F0665E8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAH8</accession>
    <name>A0A1Y1UAH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_582781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869277.1">
        <property type="nucleotide sequence ID" value="XM_022013582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAH8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAH8"/>
    <dbReference type="GeneID" id="33555390"/>
    <dbReference type="InParanoid" id="A0A1Y1UAH8"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="614" mass="66628" checksum="B482A253D8983888" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAI9</accession>
    <name>A0A1Y1UAI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_633742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869266.1">
        <property type="nucleotide sequence ID" value="XM_022016652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAI9"/>
    <dbReference type="FunCoup" id="A0A1Y1UAI9">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAI9"/>
    <dbReference type="GeneID" id="33558461"/>
    <dbReference type="InParanoid" id="A0A1Y1UAI9"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="174" mass="20242" checksum="6F306DFFBB4DDF4A" modified="2017-08-30" version="1">MSVLRSRALTAAVWSRPLAVRQLHITVIRRADPYVLPLDPSLNQASSSSSSTEPLPEHGEWPLPQPLDRTGEDEKTIRARLVYQSRKRGMLEGDLLISTFARDHLGSMSLEQMREFDKLLDEPDWDIYYWSIEKREPPTRWKDTELLAKLRQHARNEGKVVRKMPDLMQEEPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAQ0</accession>
    <name>A0A1Y1UAQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_604009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869347.1">
        <property type="nucleotide sequence ID" value="XM_022013971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAQ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UAQ0">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAQ0"/>
    <dbReference type="GeneID" id="33555779"/>
    <dbReference type="InParanoid" id="A0A1Y1UAQ0"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000186">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="571"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="762" mass="83788" checksum="283E763B8DC25E79" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB51</accession>
    <name>A0A1Y1UB51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_604205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868968.1">
        <property type="nucleotide sequence ID" value="XM_022013976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB51"/>
    <dbReference type="FunCoup" id="A0A1Y1UB51">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB51"/>
    <dbReference type="GeneID" id="33555784"/>
    <dbReference type="InParanoid" id="A0A1Y1UB51"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="178" mass="19877" checksum="9ACC0252E8B3687C" modified="2017-08-30" version="1">MTVHGLRIRLARHGIRNQALYHLVVMDRSKARNALPLEKLGEWDPIPQVTSFRDLHPSSFVFGKQTVPPVKERRVIWNEERIKYWLAQGAEPSDSVTKLLELGGILKAGDRHASHFKYQTLSKNLVKTASNEPVKEVMDSTKQNSKASKPKGVNRRPTPTPPSPSSSSPASHSSQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB65</accession>
    <name>A0A1Y1UB65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869473.1">
        <property type="nucleotide sequence ID" value="XM_022018491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB65"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB65"/>
    <dbReference type="GeneID" id="33560300"/>
    <dbReference type="InParanoid" id="A0A1Y1UB65"/>
    <dbReference type="OrthoDB" id="2538408at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="340" mass="37017" checksum="6418D0C10ED35F7F" modified="2017-08-30" version="1">MSPAAIYSVYTSPQHAPIPGHLPTLIVTPHGQPNQILYTYLHTEENRVNYLLTPSPQGDLCVAKLFPPSNNSAQNSSSSLPNSSKQPKPHNVVRCEASRDLRWTIENTGVMSPIYKIVNQDDTPLYQISKPNPNADFWTMFYFKYAGHQIPPRRIEFGKISKNPPERGGGTRISITGRSEDEKQVWQTLGIGNEDCVEWVVCCAVLNLLDDEILRHAEKKNAPNPAAPAATAPVIARGGRSGNRGLGAGIASTAPPSGPPAANLAQAYRQNPPPQIARIPPGQPGSAYRNPPQQQQQPGYGRPPPGGPSPQQQQQQPQQQQRNGFFNRPSPAATAGGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB81</accession>
    <name>A0A1Y1UB81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_603316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869452.1">
        <property type="nucleotide sequence ID" value="XM_022013960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB81"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB81"/>
    <dbReference type="GeneID" id="33555768"/>
    <dbReference type="InParanoid" id="A0A1Y1UB81"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="458" mass="50449" checksum="D8C339281F43B1B0" modified="2017-08-30" version="1">MPTESSPFPSLTPSTSSALSYLSSSQFIKCAICGSGALDSGSSPRHQDRHGVVLLVSPPERICGSCVRSQDGRSRAVDSFEEEMASMSVTDLVIEEAREGENSEGASDEERGRIPSVHAATRSRPIPFRGSVSCQSRSDSQSQSLPAQHSRQWNTLSPSIPAISEQPATDIIWDEAEEDEPVLNPLLDVTKLRVSSAGRGALFAGSIFRGTQTSGRSAYEVEVKFLDVNLAESTVSGYLSISHLTDAHPHLTTFFTGEIIGPKFGFLTGARYGATEHDDMRHWGRFEQFRRPSTRADILRPDMVFRDPLPDWSRGETQAKERDFVFLRLKERFLVPDHTVRDISGASFAGFYFAMIDLAPSATADETPASPSSPTIPKTALSISPTSPTVFRRMSSSGDRAHLPRRRSSSVKVREEVSPPRSEATIRGYYFHSLNQEPFQELFLTHVPAKSDGTFEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB87</accession>
    <name>A0A1Y1UB87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_634877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869008.1">
        <property type="nucleotide sequence ID" value="XM_022016769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB87"/>
    <dbReference type="FunCoup" id="A0A1Y1UB87">
        <property type="interactions" value="723"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB87"/>
    <dbReference type="GeneID" id="33558578"/>
    <dbReference type="InParanoid" id="A0A1Y1UB87"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="233" mass="25267" checksum="BE9CDD753E4C6E0C" modified="2017-08-30" version="1">MKVYSLSLLSVTPSSPARATMLGTSQDLSSYSFYQRGSVGEFMQFFTKTVAERTPANQPSSVEENNYKAHVFRTAGRGPNSMGMAAVMITDMEYPYRPAFSLLTKLLDENAPLLAQLPSPSAAPSFGSASANAFGGNPSQAAAGGLPPAQKGKLEGTLATYLTKYQDPKQADTIMKVQKELDETKIVLHKTIESVLERGEKLDNLVERSNALSAQSKMFYKTAKKQNSCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC14</accession>
    <name>A0A1Y1UC14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_682363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869752.1">
        <property type="nucleotide sequence ID" value="XM_022019147.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC14"/>
    <dbReference type="GeneID" id="33560956"/>
    <dbReference type="InParanoid" id="A0A1Y1UC14"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="972"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1115"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="444"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="657"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="976"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1290"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1547" mass="171989" checksum="E6F7D070677760D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCX5</accession>
    <name>A0A1Y1UCX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_629343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870002.1">
        <property type="nucleotide sequence ID" value="XM_022016198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCX5"/>
    <dbReference type="FunCoup" id="A0A1Y1UCX5">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCX5"/>
    <dbReference type="GeneID" id="33558007"/>
    <dbReference type="InParanoid" id="A0A1Y1UCX5"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000023">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="78" mass="8757" checksum="DAC285513C0911DE" modified="2017-08-30" version="1">MSRVAQPELKKFMDRRLFLHLQGGRNVSGVLRGFDMFLNLVVDNAYEELGAGIRKPCGMVVIRGNSVSSMELLDSMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD56</accession>
    <name>A0A1Y1UD56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_101398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869667.1">
        <property type="nucleotide sequence ID" value="XM_022011910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD56"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD56"/>
    <dbReference type="GeneID" id="33553718"/>
    <dbReference type="InParanoid" id="A0A1Y1UD56"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="195"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="351" mass="38595" checksum="B97EE7DE09C43A31" modified="2017-08-30" version="1">MTVEISQSAESDIRSIYDLYQSTVGALPFYALPFDKFQELVVEPRSTIFVARNKSASIIGFALCVLIRTGSATAKAAQHLKGCLSLLIVDPSHRCQGIGSALHTEALSFLNSKVFASLSLSHPIPNHGTLQLGSTFPRFFPGVPNGPEFDDAAAFFKKRGWTYGKEDSIDLYRTVVSGKALDFHNLTKRAEENGLTFRSPRQEDEEALYKLEKENFDNSTGWPDAFPDLIDSGHRDDVWCVFTKEGRLIGATVAALAPDPESNDRENPFHASLAWPRTLGKRCGVIACVGIASAERGNGAGVALVATALNNLALRGADGCFIDWVHLDGFYELVGFKQWERSYREASREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE93</accession>
    <name>A0A1Y1UE93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_628509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870459.1">
        <property type="nucleotide sequence ID" value="XM_022016121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE93"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE93"/>
    <dbReference type="GeneID" id="33557930"/>
    <dbReference type="InParanoid" id="A0A1Y1UE93"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="216" mass="23520" checksum="59FA492DED2CB60A" modified="2017-08-30" version="1">MTASRAITNKEQKLAVVGSGGVGKSAMTIRFVTSQFYDQGYNPTIEDSYRKQVVVDDEAVTLEILDTAGQEEYAAMADQWYSFGGGFLLVYSITDRSTFEAIPGLHQDILRVKDQSYVPCVVASNKCDLGRLRAVGQLEGRDMARRLSAPFIECSAADGVNVDVAFRELIKLVRRNEKRMALAAQRLMGGPLAADPLSSIAGSESGVDKCCKCVMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEB2</accession>
    <name>A0A1Y1UEB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869996.1">
        <property type="nucleotide sequence ID" value="XM_022016194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEB2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEB2"/>
    <dbReference type="GeneID" id="33558003"/>
    <dbReference type="InParanoid" id="A0A1Y1UEB2"/>
    <dbReference type="OrthoDB" id="3204900at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="337" mass="35922" checksum="E9FAC1D92CE9DAC1" modified="2017-08-30" version="1">MDSTFAVPALPRREGHGSRPLSMSKTQNLSGSPLTSDHHHPEAKQVNNSGANRLKRLSLVARPPIREAPASPQRAPGHTNTTPSTPGPQPAGGPSHRRAMGMRSSISYSPALARREASSHEETRSEFETWAEERGYFGEMIAGPSRSSGKRSSVQSLEGSCPEAKNKDDDRRGETFVERHADLLTLIAQKERRVNDLRQELASQEASLNQLKTRWTAIISKSAPPAPSRPVRAGHHPLSGTSTIRPSPIEPPQTLAADPGPAAEHATGTNSTALTPSDGQSLASFITSLGTTPEGLLGQDTIEGGKRFWTQLVKTVSAAAGGTVPDAQSPQPSKVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEB7</accession>
    <name>A0A1Y1UEB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_628397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870440.1">
        <property type="nucleotide sequence ID" value="XM_022016117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEB7"/>
    <dbReference type="FunCoup" id="A0A1Y1UEB7">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEB7"/>
    <dbReference type="GeneID" id="33557926"/>
    <dbReference type="InParanoid" id="A0A1Y1UEB7"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012711284" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="42"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="235" mass="25199" checksum="1429263530102DAD" modified="2017-08-30" version="1">MMRGSVSCASLLLLSLLPSISAYDIQGRIAFNNVLPESTGVPVGSKVSLDHGARYAYITPSGSFDLSYVPEGQHILEGFVPGYIMESFLVTINETIHIQPYHVARAPLPLSVPSFPHPIQMKAFHKEDYFTSPPSFQLLAMLKNPMVLLMIFSGIMMFGLPKLNEMLDADPQLAAEVAAARKKMMGGGGGSVGLVESISNSLQGDSDGGASSARSDRASTPSRNNNKGAQKRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC9</accession>
    <name>A0A1Y1UEC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_629389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870016.1">
        <property type="nucleotide sequence ID" value="XM_022016208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEC9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEC9"/>
    <dbReference type="GeneID" id="33558017"/>
    <dbReference type="InParanoid" id="A0A1Y1UEC9"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="234"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="499" mass="55396" checksum="DD1894DAC59CC058" modified="2017-08-30" version="1">MKRKATAYPERLCLPSLSTSSSSSLTARSVPDSIDGYSSNTSRSILSRSESTAGRHGLQSAKSVQSIQTEPEQDRIVGTLTGVVRGEQVVIYIHSTSSYTVIGSDATCNVRLWDQDVSRKHMRIYSIRTDSALMVTCLHDISVNGFTINGSRFRSRTPISVGQRKVYTQAAILMDGDVLRFAGTSYQFVYEHNFQDFPLPCHSASPIEEFGQLPDPIFGPNDDPRDKYDAHPWIIHNYQLGSGAYAYVNLASHKAGGLQVACKTVKMLTEEVDEEEETSDGDSLQSWTTEGSSSTKRKKDVQAYLEEVKTLRVLCHPNVAALLDVIHDPEQSRVHVFMELVTGGDLFSHLERSTLTEGEVAFLAYQLCKGIGYLHELRLAHRDIKPENILLAVSDAYPKVVITDFGHAISETQLLELIPLNPDEFCARIYPVTGTIEYLPRERLIALLRPPRGVQGTLEEVGIGWAEKRNQIAGKWLEEEFALDSWALGCESTAVVTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEE2</accession>
    <name>A0A1Y1UEE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_496581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870531.1">
        <property type="nucleotide sequence ID" value="XM_022012946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEE2"/>
    <dbReference type="FunCoup" id="A0A1Y1UEE2">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="GeneID" id="33554754"/>
    <dbReference type="InParanoid" id="A0A1Y1UEE2"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000700">
        <property type="entry name" value="Solute carrier family 45, member 1/2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="641" mass="69959" checksum="E8C65FEDCB1E3EC0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEH1</accession>
    <name>A0A1Y1UEH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_656846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870529.1">
        <property type="nucleotide sequence ID" value="XM_022018851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEH1"/>
    <dbReference type="FunCoup" id="A0A1Y1UEH1">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEH1"/>
    <dbReference type="GeneID" id="33560660"/>
    <dbReference type="InParanoid" id="A0A1Y1UEH1"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="57"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX36428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="446" mass="50055" checksum="9F7BA24A56B148EB" modified="2017-08-30" version="1">MTRILDPPTFSDSPFFFDRRQLAQPQREVHHVQPHSNPVVAYYHPKGVGNYHYGERHPMRPQRLELTNQLVLGYGLDKAMTMHNPRRATDEELANFHDSDYIAFLKRVTPKSAQSLTEEEQKYNVGDDCPVFFDVFAFCQQYTGASLAAARKLTSGSADIAINWSGGLHHAKKGEASGFCYVNDIVLAILELLRYHARILYIDIDIHHGDGVQEAFYSSNRVLTVSFHKYSADFFPGTGNLSEIGSDLGKYFSLNVPLQDGIDDESYISLFKAVMEPTINTFRPSSIVLQCGADSLGCDRIGSFNLSIAAHGECVRFIKSFNLPLLVLGGGGYRQSSVARCWAYETGVLAGVTLPDDVPDNQYYEFYGPDYKLHPPLTGQIQNLNSKQSLENIRVVIREKLRYLNGAPSVQMQEIPPDLYGFLQSEDRSTEETKEEMGAQGLEIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEM6</accession>
    <name>A0A1Y1UEM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_514189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870093.1">
        <property type="nucleotide sequence ID" value="XM_022012970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEM6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEM6"/>
    <dbReference type="GeneID" id="33554778"/>
    <dbReference type="InParanoid" id="A0A1Y1UEM6"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="239" mass="26259" checksum="9DDF7AB113FD8303" modified="2017-08-30" version="1">MQLHSFSHQHEAARAVAELIVSRIKAFGPNMNRPFVLCLPTGSTPVPVYRELALMCMNGVISFEFVITINLDEYFGLPADHPQSYAYFMEQEFFSKVDIPPSQTHLLSGINPDPEFECARYEALIEKLGGIHLLFAGIGANGHVAFNEPGSSFGSRTRVVALDEDTRRVNARFFASVDEVPTHALSMGLGTILDAREIIVLATGASKRHGVQEAIEGPLTHLASLNAYPHKYHTLTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF09</accession>
    <name>A0A1Y1UF09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_626592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870692.1">
        <property type="nucleotide sequence ID" value="XM_022015907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF09"/>
    <dbReference type="FunCoup" id="A0A1Y1UF09">
        <property type="interactions" value="540"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF09"/>
    <dbReference type="GeneID" id="33557716"/>
    <dbReference type="InParanoid" id="A0A1Y1UF09"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000089">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="212" mass="23173" checksum="337AE67C5AE27D2C" modified="2017-08-30" version="1">MVLVLVIGDLHIPNLTHDLPAKFKKLLVPGKIGQIICTGNVCDRETYDYLRTIAPEVHVVRGEFDENTHFPLSLTIQHQSLRLGVVHGQQIVPAGDLDMLAAIGRQMDVDVLISGGTHRFEAFEAEGRFFINPGSATGAWSGLWNGDATPSFALMDIQGPAIVTYVYQLVAGEVKVDKIEYRRQEPPRDQEAMSPRLSAGAGSNRAEVAAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF38</accession>
    <name>A0A1Y1UF38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870722.1">
        <property type="nucleotide sequence ID" value="XM_022018276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF38"/>
    <dbReference type="GeneID" id="33560085"/>
    <dbReference type="InParanoid" id="A0A1Y1UF38"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="373" mass="39048" checksum="01B977587DA14818" modified="2017-08-30" version="1">MGFELTAIEIAAIGAAGTAVLVVIIFIVYSIRRRRTIKSKNQLSPGSSRARGSPGKAWGFSKWNSTPAGTPSPAGTGIIGVGLTPPYPSCPLQTPPSSGPLNPEPGLTPGPSTSPSTGLLSLLTPASSSSNKLKKTTGSPVVRAKSPRSPKTRNKTKGRKAAAGEMVNGISPSDSFHRPESQDMVMVTYEEGLANMGMVRPPHILRYSEPPAFEEARQAYPITGTSSDSSAGESALVVRGETPQRWDRGDEPSVGQSGTRRQYRRKQQNREPKQQAEHDRLYPRAERSGRKKHRKGRRDDEDDQSTWLPSYYHSPEANRRRADGGESDLSYRREGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGSTRYPGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF75</accession>
    <name>A0A1Y1UF75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870737.1">
        <property type="nucleotide sequence ID" value="XM_022018282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF75"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF75"/>
    <dbReference type="GeneID" id="33560091"/>
    <dbReference type="InParanoid" id="A0A1Y1UF75"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="47"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="62148" checksum="A9EEB360F064CCF9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFN2</accession>
    <name>A0A1Y1UFN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositolphosphorylceramide synthase subunit Kei1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_627325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870897.1">
        <property type="nucleotide sequence ID" value="XM_022015988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFN2"/>
    <dbReference type="FunCoup" id="A0A1Y1UFN2">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFN2"/>
    <dbReference type="GeneID" id="33557797"/>
    <dbReference type="InParanoid" id="A0A1Y1UFN2"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="257" mass="28614" checksum="C77DE91A698EBA11" modified="2017-08-30" version="1">MGLNLRRLRPEAVFDSFLGILDIKLGAEIILLFALINKVAGVYGFITIVVGGTFTQLAFYAYSIVTLFVLLWALKQVKAETSESTVLVAHLYTADHIVQSLFHYLFYYDYWYLQPHDGRRSINSRAQQDLIDLAVSRGEVSNPAGGGGDGQDGMRAALALEIWERERIFAIWTVILGFALKVYFIFVLYSYAAHLRSSTYHALPMTAQPRSAAGIQPKGTGLEGQRLVQSGAGGAGAPHRKQKNIGYVEDEEDFEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFS0</accession>
    <name>A0A1Y1UFS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_629525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870044.1">
        <property type="nucleotide sequence ID" value="XM_022016218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFS0"/>
    <dbReference type="FunCoup" id="A0A1Y1UFS0">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFS0"/>
    <dbReference type="GeneID" id="33558027"/>
    <dbReference type="InParanoid" id="A0A1Y1UFS0"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="211" mass="23102" checksum="E113E2C0EF414D05" modified="2017-08-30" version="1">MVGKTLPRKLVVLGDGACGKTSLLTVFTKGYFPTTYEPTVFENYVEIMSIEGQTVELSLWDTAGQEDFDRLRSLSYADTHVIMICFSVDMPDSLENVETKWIEEVNQFCPGVKIVLIALKCDLREDPTVREKLERRGMHTVTYDEGLAVARNIRANRYLECSAKHNRGVQEALHEAARVSISTKPKGNGGGPGGGGGGAKGDRLGSCCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFT1</accession>
    <name>A0A1Y1UFT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_642376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870898.1">
        <property type="nucleotide sequence ID" value="XM_022017483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFT1"/>
    <dbReference type="FunCoup" id="A0A1Y1UFT1">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFT1"/>
    <dbReference type="GeneID" id="33559292"/>
    <dbReference type="InParanoid" id="A0A1Y1UFT1"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="431" mass="47888" checksum="4C0EE93A7BEFA040" modified="2017-08-30" version="1">MKLINKHVERDGSGYVTLRPEDDEDMWHVYNLISEGDEVRALTMRKINTLSSTGTTDSYRVRVNLTLQVVKTTFSPAASSSTSSGGQEKKEPTASLQVSGKVIQENDYVRMGAFHTIDLEANRDFRLTKATGWDSVALERIEESTKEGRGAEVGAVVCGEGTAAICLLSEHMTVVRQRIDTAVPRKRKGGTSGHDKAMETFFSNVYQAVLRLIPYQTLKAIVIASPGFTKESLYDYIFHQATLTNNKPLMASRSKWIKVHSNTSHVHSLVEALRAPEVSKMLQGAKFAREGLGLDAFHKMLATDEMRAWYGPEHVALAVDRGAVGTLLISDDLFRSSDPVTRNRYVEMVEAVRARGGEALIFSSMHESGQQLNLLTGIAAILTYPLDIEIVEMEEREEKERLEKEANGVQVDDDEEEEEQQQQHDGAPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFU6</accession>
    <name>A0A1Y1UFU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_627717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870992.1">
        <property type="nucleotide sequence ID" value="XM_022016033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFU6"/>
    <dbReference type="GeneID" id="33557842"/>
    <dbReference type="InParanoid" id="A0A1Y1UFU6"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="314" mass="34801" checksum="21FC5BA1595FD64D" modified="2017-08-30" version="1">MAGMRSFSSGSSRACIRCSGRKRKCDRVRPACGECVASKHICEYSSSDRRRGPPAGQARAIEARVKDCERVIWHLLQLEGVIQALKSQDANGETLSGCPLHRHHRLTSEYFSTHPLQTPSDLRQFYQACLNAPQGESERGARLSPDFERSRASSAFNQLDRPVLEHHPQISNGHLSTEDFPGIQCIDHSPPTHCCNDDLPSVLRPLSDRQTFQWPTMTVPHTGRSHWTRSSPQSPARPFPGTTTPLQAMDYTAGRYDLSIGSSLNGIIQTSGPGIVEPSGLQTDNFASTLQIRRYDGSSADNNALCNEDPEIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG60</accession>
    <name>A0A1Y1UG60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_624589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871089.1">
        <property type="nucleotide sequence ID" value="XM_022015717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG60"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG60"/>
    <dbReference type="GeneID" id="33557526"/>
    <dbReference type="InParanoid" id="A0A1Y1UG60"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49220" checksum="C873406B20DBFCFF" modified="2017-08-30" version="1">MVTESQSPDIGVHGLISTAFTELGHLRVITLLIQYPSIDKIPSPTNLRERIRQLSVIHPILGAKQKTGKDGKAYLEPSDEQPKVYRWEYEPDGLPEHDIISHTILDRAFNKALRDMKDLNNLRIQVDHIIPPETTDPFPSFIAISADHTLVDAAGLKTFAQHILNSKLDISSSLEKEPFYPHHVEDLMDFVPEGPLDMPVPDHWPMNCSNPMNVPGAFSHHDYPLSILERVKSQGKRHGIPTLNPVLELAFLTALTSVVPETENQVLNCYTMTDERPGLGSKAPKWSHNYFSVPSSKRTIFPLDKTDFWAAVKIQVETTKDEAYIRGGRYGAGFVKAMPSPVKDILAGKVISESPYFGTIFFSNLTRVDLPEGANDIRWTAAATPFLAPMIVNLIGSSAGLRVTIAFRDGAGLTANQADAIGVTFGQVLERLAEGETGTLATLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG88</accession>
    <name>A0A1Y1UG88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_424481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871119.1">
        <property type="nucleotide sequence ID" value="XM_022012741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG88"/>
    <dbReference type="GeneID" id="33554549"/>
    <dbReference type="InParanoid" id="A0A1Y1UG88"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="215" mass="23836" checksum="43FCDAD7A7A34D53" modified="2017-08-30" version="1">MNFTASQLAALCLGIVFLIIIILGLLFWLYASKRARREDHEASAANVGRWKEVAEIAVPSVPTAPKLRSQFSMQGIRNPHESVPATFILPSKRLSRSVDASDRQSQESRRKAAGSRELRSDKGITLVEMGGEAEHPGLQKSRTKLSTLKREGEKPKYPHESAERQKWGVRRARGTPKSSAASSPRKHGRRQRLAANGSAVVGLGARNERSHKDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGG9</accession>
    <name>A0A1Y1UGG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_455320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870673.1">
        <property type="nucleotide sequence ID" value="XM_022012829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGG9"/>
    <dbReference type="FunCoup" id="A0A1Y1UGG9">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGG9"/>
    <dbReference type="GeneID" id="33554637"/>
    <dbReference type="InParanoid" id="A0A1Y1UGG9"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="243" mass="27025" checksum="9E6142BCF3EE9463" modified="2017-08-30" version="1">MNSLNSLGNRQIASLNADLAKMESGEAGPSVQGQITTTLGALNRLIDDYDSMARKEMVTAAREKANTRVAKLKEEHKNLKLRFEQAKSEGQQRKRDELFSSTSSTSHYSSASGSATQRKATNPNAPPSPIHESPFATNASTHSYTGPSAREDFALREHTFLQESENSIDQYIAQGRSVLENLVEQRGMLKGTRRKLLDAANTLGLSRETIGWVERRTKQDAWIFGVGATFTLFSFWVIWHYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGT0</accession>
    <name>A0A1Y1UGT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF423-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871311.1">
        <property type="nucleotide sequence ID" value="XM_022015806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGT0"/>
    <dbReference type="FunCoup" id="A0A1Y1UGT0">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="GeneID" id="33557615"/>
    <dbReference type="InParanoid" id="A0A1Y1UGT0"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="118" mass="12235" checksum="BB7DD0FBF9AD9EB4" modified="2017-08-30" version="1">MNATNVWKSGALLTAVGMSCGAFGSHGLRSRQPPLSERSISNWSTASNYLIYNGLALLAISFHPALSLSRRARIATGMIASGAMVFSGSIFGLVLGKDVWKKVLGPLTPLGGVAMIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGU6</accession>
    <name>A0A1Y1UGU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870795.1">
        <property type="nucleotide sequence ID" value="XM_022018293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGU6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGU6"/>
    <dbReference type="GeneID" id="33560102"/>
    <dbReference type="InParanoid" id="A0A1Y1UGU6"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="35809" checksum="EBF4F8C238FD8B23" modified="2017-08-30" version="1">MSTLLRWTKIPAEVLPRSSHSISVIQNSAYIFGGEIQPRQPCDNVVHKIGIQDGKYEEVPGSGDIPPPRVGHVAATVSNQIYVFGGRGGKAMTPLEEQGAVYNFDPSTSSWSLLKPTSSSFPQARSYHCATSTSTHLIIHGGCGGAASGSRFKDLWAFDVSSRAWTQLPDAPGDPRGGSAIAHAAGKIWRFGGYNGKTEVGGEIDVIELSLTSGSLSTAQWETRPFPKESVDGPAGPGSRSVCALLALEKSSKLVTFLGEGNPSPTGGHDAAGNFYADVWTYDPSNNRWDEVRVDRTGGNPGERGWFAATASDVGPVLWGGIDGNNDRLGDGYILCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGX5</accession>
    <name>A0A1Y1UGX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI inositol-deacylase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_628294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870426.1">
        <property type="nucleotide sequence ID" value="XM_022016112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGX5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGX5"/>
    <dbReference type="GeneID" id="33557921"/>
    <dbReference type="InParanoid" id="A0A1Y1UGX5"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="3">
        <location>
            <begin position="362"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="563" mass="61206" checksum="AA7E47F771427F4D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH05</accession>
    <name>A0A1Y1UH05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_601544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870853.1">
        <property type="nucleotide sequence ID" value="XM_022013933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH05"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH05"/>
    <dbReference type="GeneID" id="33555741"/>
    <dbReference type="InParanoid" id="A0A1Y1UH05"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="107"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1151"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1163"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1230" mass="132548" checksum="441E4FD11652C84D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH44</accession>
    <name>A0A1Y1UH44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional Coactivator p15-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_470391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870885.1">
        <property type="nucleotide sequence ID" value="XM_022012875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH44"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH44"/>
    <dbReference type="GeneID" id="33554683"/>
    <dbReference type="InParanoid" id="A0A1Y1UH44"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="63"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="14170" checksum="A45F0F28DBC195A4" modified="2017-08-30" version="1">MPKKKRVDSDEESGSEQDARPSKVESISEDEEPVKAKAKNGESSMSTGAGVEVLKNADKNSYFNLSDTRRVTVRPYSGKILVDVREFYRDKATGEMKPGSKGISLTAEQWKVLRDNMEVVDRLVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH59</accession>
    <name>A0A1Y1UH59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871357.1">
        <property type="nucleotide sequence ID" value="XM_022015825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH59"/>
    <dbReference type="GeneID" id="33557634"/>
    <dbReference type="InParanoid" id="A0A1Y1UH59"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="258" mass="29193" checksum="DB00C012481AE815" modified="2017-08-30" version="1">MPSDPIYLNQYTPPQAPREVYGDTPLEDYDQNFVFPPKVLRSDRVELRPFVPSLHAQALAEGVSANPEVMEWLPYRCETLDDARLFIESMFRSQPSALYHAIYSAPPGVDPTPPVDEWKIAGFLGIINASAKDATAEPGFIIIFPKYQRTHVLTHAAGLAMHRILDPESEGGLGLRRCQWYTTVLNLKSQAAALRLGYKHEGIIRAQRVLLEGWQGSRPGRPPHEKNQARDSWLASVIWEEWEGGVREHIDKLMARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHC1</accession>
    <name>A0A1Y1UHC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_451328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871489.1">
        <property type="nucleotide sequence ID" value="XM_022012819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHC1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHC1"/>
    <dbReference type="GeneID" id="33554627"/>
    <dbReference type="InParanoid" id="A0A1Y1UHC1"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="505"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="693" mass="73284" checksum="CBF38448CDAA6A77" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHJ9</accession>
    <name>A0A1Y1UHJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_382192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871518.1">
        <property type="nucleotide sequence ID" value="XM_022012635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHJ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHJ9"/>
    <dbReference type="GeneID" id="33554443"/>
    <dbReference type="InParanoid" id="A0A1Y1UHJ9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028067" description="Concanavalin A-like lectin/glucanase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24289" checksum="CFB3061D30B3440E" modified="2017-08-30" version="1">MSFVHMIYLLLSVWLCRPILAQTNIFISDQSPLVSFHPEWVDSGITNKTTKEASWNITYSEVSWSGVDITSGPVGQGCSTHWTEATDASISMQFSGISLYAWGNITARGGEGNASLAYGNTTLNIDGKNVSSYDPVNGTLGMISGVSAGWHNATIYYEGSGRLYFTGFTLTLNIQDDFNTTYLATNGSSTHPINPAFNLSGSDGDDWSLQSIATRAWPHIRCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHS7</accession>
    <name>A0A1Y1UHS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_622664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871610.1">
        <property type="nucleotide sequence ID" value="XM_022015497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHS7"/>
    <dbReference type="GeneID" id="33557306"/>
    <dbReference type="InParanoid" id="A0A1Y1UHS7"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="75" mass="8508" checksum="4130E132D7D0D5E4" modified="2017-08-30" version="1">MNICFFLLLVILFALAVLTSWNKHVLLLLGVTSLFWFSMLWFIAEISKVQTRPDNMPPVDVDPPTSAAAESKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI36</accession>
    <name>A0A1Y1UI36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_656327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871182.1">
        <property type="nucleotide sequence ID" value="XM_022018841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI36"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI36"/>
    <dbReference type="GeneID" id="33560650"/>
    <dbReference type="InParanoid" id="A0A1Y1UI36"/>
    <dbReference type="OrthoDB" id="2571149at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="50814" checksum="DF7C1BAB6675821C" modified="2017-08-30" version="1">MKQALSSPQYFKARVSLQFVPDYPAYLAKAPKSISLPANPPPALPFHKDTAHTIPTKWGLYRSLLRDCRQHDQPAKSSEPSLVPAQLDQTPGAGPSRSHKPLRWPHIHEMVQTDWRNSRHVLSIAQARQFLTYYYQILSDLRSSSPESLARLAAIEESAQRTMIMHRLDVKDAEAEREALKASRRKQWGKMTGGFLYPNAFMPPMPKLRPQPEWIAGTYRSRMKKKEKSIKAMRDAEEARDDILEEIQFLSRLERLDSKVWRLEGSGGWLESYRKTKEAGEAMQRAGAARANATFTEETVKKVLEARKARHKTYMAFAWQRKEEKEARIEARKEERANFYNNKQRAEEMKIERWMREDKSIGRGKNLFEASDQYIYWDEANGGGYVMTRKWKPTTSYGIKKQTLAEAKEDLKQRQEKELPIGLAGSPGSGRTVAEASSSQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI38</accession>
    <name>A0A1Y1UI38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome activator pa28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_622996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871707.1">
        <property type="nucleotide sequence ID" value="XM_022015538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI38"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI38"/>
    <dbReference type="GeneID" id="33557347"/>
    <dbReference type="InParanoid" id="A0A1Y1UI38"/>
    <dbReference type="OrthoDB" id="6591885at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="125" mass="14515" checksum="3554DC833375740D" modified="2017-08-30" version="1">MIVQDLRVWLELEIPLIEDGNSFGADVQSHLLRELTEAYKRSNGFQNGARTHYLDRLKLTQDWVKYPNLMDFPAAIAASDRFDHVLLRSYFRSILTIYGGLLTKFERNWEKVVNPKGGSYRGGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIG3</accession>
    <name>A0A1Y1UIG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871324.1">
        <property type="nucleotide sequence ID" value="XM_022015812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIG3"/>
    <dbReference type="FunCoup" id="A0A1Y1UIG3">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIG3"/>
    <dbReference type="GeneID" id="33557621"/>
    <dbReference type="InParanoid" id="A0A1Y1UIG3"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="857" mass="94332" checksum="57A10EC2C2653475" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIK9</accession>
    <name>A0A1Y1UIK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_407046</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871890.1">
        <property type="nucleotide sequence ID" value="XM_022012701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIK9"/>
    <dbReference type="FunCoup" id="A0A1Y1UIK9">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIK9"/>
    <dbReference type="GeneID" id="33554509"/>
    <dbReference type="InParanoid" id="A0A1Y1UIK9"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="323"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="623" mass="68910" checksum="F6DD838997675BC5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIT4</accession>
    <name>A0A1Y1UIT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_411837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871960.1">
        <property type="nucleotide sequence ID" value="XM_022012710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIT4"/>
    <dbReference type="FunCoup" id="A0A1Y1UIT4">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIT4"/>
    <dbReference type="GeneID" id="33554518"/>
    <dbReference type="InParanoid" id="A0A1Y1UIT4"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="5">
        <location>
            <begin position="93"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="437" mass="48367" checksum="81488BC648C0C179" modified="2017-08-30" version="1">MRASKVPSSRIGRLLHYGSLAASMSLGAASESIRRTAGGNAGKGSVFMSDANIRRLVASLGRMRGAALKLGQFMSIQDNHLLPPEIEQVLQQVQAHANYMPEWQMDQVMSSELGSEWQSLFSSFDRTPIASASIGQVHRGVLASSGQPIAVKIQFPGIASSIHSDLNNLSVLLRTSSLLPKGMYLQNTIAVMRRELEDECDYVREGAAGRRFGKLLANDDFFVIPQVVDEATTGKVLTTEWAKGKPLSRMKGMSQETRDKIGENILRLCLQELFHFRFMQTDPNWANFLYDSSAGKITLIDFGASREYTKEFMDGWFRLLDAALRGDRTAMKDESENLGYLTGEENEEMLKAHLDSMALIASPFSTRGAYAFANQTITDSVRALIPVMLKYRLTPPPSETYSLNRKLSGAFLMCARLGANVDCGKLWNEYVGGYKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIW9</accession>
    <name>A0A1Y1UIW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_623868</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871919.1">
        <property type="nucleotide sequence ID" value="XM_022015636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIW9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIW9"/>
    <dbReference type="GeneID" id="33557445"/>
    <dbReference type="InParanoid" id="A0A1Y1UIW9"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX37932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="91" mass="10578" checksum="D827755AE1BA3BC0" modified="2017-08-30" version="1">MSGAVQSFSAAHRSYVKSLYKAYLVNARDWIVDRPLWRRRCVEIRAEFERNRNITDPRALAIVLEQAEQRLADLAHPSPYIHPTDPDGSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJZ4</accession>
    <name>A0A1Y1UJZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_402610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871834.1">
        <property type="nucleotide sequence ID" value="XM_022012687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJZ4"/>
    <dbReference type="GeneID" id="33554495"/>
    <dbReference type="InParanoid" id="A0A1Y1UJZ4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="435" mass="46277" checksum="7CED920C32082366" modified="2017-08-30" version="1">MSPSDPLASSSLPLNSASSDILFTQKDDPPSRHRRRTTLASSSEAIFTDWRKRGLGRKIAPWMNPYSTIVVESPTASSLPQRSSASSSRIPLTTNADVEYKGSKGHLERSVSSSESIADGQVPADQRPTLLSPTIALVPHYAPDSLGGSLSLARSSSPRSTSPRHAGAASGLVALKTSSKGSKLRQPRPRSDPGSAIEWNTLQEALGQEHCCDPSNSDMEAVSVYPRENLTPQSGHIDHCAPFDPEMVDTSRSSGQSLDMMSVTSPYPSPLPAGRLREARASSIDHIDTMSTLGQEEDELGSKDDNMVNAKQIRPPLDTEGSTAITSPYALFPIVASLLVSSQHMSASKLAPENPISDLEASSRATLNNATSFAVNADPYSQPGHPNIDYAYHAVTTDAAAQSLGRQRVSAEIRSGSIVSLIAQNGPVEHFGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK76</accession>
    <name>A0A1Y1UK76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_352926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872304.1">
        <property type="nucleotide sequence ID" value="XM_022012560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK76"/>
    <dbReference type="GeneID" id="33554368"/>
    <dbReference type="InParanoid" id="A0A1Y1UK76"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="232" mass="25021" checksum="4C3DDD7D491DBEE3" modified="2017-08-30" version="1">MAVVYCDHVTLASLAHRLGLANCRQAASCCCTLTPSSSGLGSPGGFTTEAMPPFRDPLSPDTSWSSSSIDYKPSAGRSRRDEYIQAKNAANEEYYGPGVKPPDRKKLKQVQRRSDVAPKSTNSKSTLTSERTNTMNEARVPARERIIGAKLDDVADLRSKPEVWVIVDSDPEPEETAPRAAATAPQESAQSTPAVWIPAQDRALWLAQVSYAMYFPLIGSSGMVKGGNGMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK86</accession>
    <name>A0A1Y1UK86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_620976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872392.1">
        <property type="nucleotide sequence ID" value="XM_022015347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK86"/>
    <dbReference type="FunCoup" id="A0A1Y1UK86">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK86"/>
    <dbReference type="GeneID" id="33557156"/>
    <dbReference type="InParanoid" id="A0A1Y1UK86"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="310" mass="35029" checksum="C32200B6A8133757" modified="2017-08-30" version="1">MAPFDLDACIDKVRDKQLLGEALIREICEKTKEVLMRESNVIHIASPVTVVGDIHGQFHDLVEIFRIGGSAPNTNYLFLGDYVDRGLHSVETISLLTCLKLRYPERIQLIRGNHESRAVTQTYGFYLECTRKYGSPAVWQAFTDMFDYLTLSVVVDDAIFCVHGGLSPSIHHIDQVKIIDRFREIPHEGPMADLVWSDPDPEKEDFAISPRGAGYTFGASIVKKFLNLNGMNHVLRAHQLCMEGYSILYDDQLSTVWSAPNYCYRCGNMASILEVSPGGKRYFNVFEAAPENERDGPNQQQPAKAIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKG2</accession>
    <name>A0A1Y1UKG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_607985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872465.1">
        <property type="nucleotide sequence ID" value="XM_022014093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33555901"/>
    <dbReference type="InParanoid" id="A0A1Y1UKG2"/>
    <dbReference type="OrthoDB" id="2564946at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="364"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="689"/>
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        </location>
    </feature>
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            <begin position="739"/>
            <end position="766"/>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="857"/>
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        </location>
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    </feature>
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            <begin position="1009"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1355" mass="144846" checksum="CCC158A23F5C2820" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKJ6</accession>
    <name>A0A1Y1UKJ6_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_624238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
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    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX38024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="144" mass="14533" checksum="0AA63C28731ED743" modified="2017-08-30" version="1">MSSQPISVPGSSPSTPLDPSKLNQTPVTLPSEPRSSNANTQTLRSPEQEPSAYLDGASGHGSEQASHPTIAETGLATSLPDDGSGMSGPGPKSGQLKRVPGGEKPEQEVISLGSFGGDGLKAKPPPPVGVQPKSPEIATFDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1UKS1_9TREE</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX38651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022015410.1"/>
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    <dbReference type="OrthoDB" id="28939at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
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    </dbReference>
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        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="118"/>
        </location>
    </feature>
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            <end position="104"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="261"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX38651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="330" mass="35239" checksum="171569BF6F4AAAF5" modified="2017-08-30" version="1">MPAAEAPTQLEQTSAVLGEYMLKGWTLTDLHCDQCCVTPLMREPTASATAESRQPIQFCALCDGPPSASAQSTATRAVQSTSRSVPSAPTGSAPASTLLQSGPNLENPIYNPSSSSDDTASQISSLLLRGYSLLGTNCPSSTCRGIPLVGYPRGQDGKKDNRRLCVECGSRWIDGGEGGGGKLKRLPVGGGDSLKGHTEKGKEKATSLLDLGLESPRTMRRNQLYGLVPTKEKEESNSSDLEDEAEVPSTMLQVQTGSQTSSAPPSLILALEHTSKSLALTLNRFAVSLERHTLGTDKEDESRYFVDVKLHMDAMKDVLGVLGMVQELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKT3</accession>
    <name>A0A1Y1UKT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_645173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872585.1">
        <property type="nucleotide sequence ID" value="XM_022017607.1"/>
    </dbReference>
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        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKT3"/>
    <dbReference type="GeneID" id="33559416"/>
    <dbReference type="InParanoid" id="A0A1Y1UKT3"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000042">
        <property type="entry name" value="SNF2 family helicase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001793">
        <property type="entry name" value="TATA-binding protein-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1337"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1665"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1900" mass="208385" checksum="9A16BEF44C2511C0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULQ0</accession>
    <name>A0A1Y1ULQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_618100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872843.1">
        <property type="nucleotide sequence ID" value="XM_022014987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULQ0"/>
    <dbReference type="FunCoup" id="A0A1Y1ULQ0">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULQ0"/>
    <dbReference type="GeneID" id="33556795"/>
    <dbReference type="InParanoid" id="A0A1Y1ULQ0"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="2">
        <location>
            <begin position="401"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="687" mass="77551" checksum="D551A7FF1D01E704" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULR0</accession>
    <name>A0A1Y1ULR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_617898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872792.1">
        <property type="nucleotide sequence ID" value="XM_022014962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULR0"/>
    <dbReference type="GeneID" id="33556770"/>
    <dbReference type="InParanoid" id="A0A1Y1ULR0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="87" mass="9529" checksum="9E847B7A03BC0D9C" modified="2017-08-30" version="1">MYLAPTLWLSASLNARVTGPTTANAPSSAPSLLPSVAPTLCALPVGCDVSRAVRRNVRQTSRQFSLLRGRNSRTGFQQLFRILHPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM31</accession>
    <name>A0A1Y1UM31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872981.1">
        <property type="nucleotide sequence ID" value="XM_022017951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM31"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM31"/>
    <dbReference type="GeneID" id="33559760"/>
    <dbReference type="InParanoid" id="A0A1Y1UM31"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="23664" checksum="017DAF53DA435EBD" modified="2017-08-30" version="1">MAEHASMRSDDPFEMDEDPLQEAADVEARFYAQGYDDGHAHGRLHGLFEGRQLGKEKAFELWEEVGFYEGSAMFWMKRLGGGGDKSNGSKSKEARALTHAKTLYEMIQGLPTSNPSPESGNPPSAAETDMDASANVDSAVTVADQGGDFDLPSLVSAIRAKYRLLCASLGIRPRLVAGSASIRSRSEGAEEDPPFDSAEMQVEGIEGPMKGVDTSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM45</accession>
    <name>A0A1Y1UM45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872127.1">
        <property type="nucleotide sequence ID" value="XM_022015235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM45"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM45"/>
    <dbReference type="GeneID" id="33557043"/>
    <dbReference type="InParanoid" id="A0A1Y1UM45"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="498" mass="53300" checksum="15C19DE3F11A5F38" modified="2017-08-30" version="1">MTLNLIEATLQEVVAALEANQLTSERLVKLYLERIDKDNIKGLGLRAVIQTAPIDQLIRTAKLLDAERAASKTRSVLHGVPVLVKDSISTHPSMGMQTTGGLLVLEGSTVKRNASIIDHLQEAGCIILGKANMTVLGNFYGTQPSGWSPRGGQTISFVKRDRGPSGSSSGSAVALSAGFCAFSIGGETCGSITSPAARAGLYGMKPTIGLVPVDECIGISSRVDCLGPMGKSAWDIAAILEKIVVPGRSFVAYTQKPYDRVSTSPIRLGIHRNHVKPEGSEDDEVTAELREEARHMFENALEKLMPMIKADPADTEDVNAMFQGPAASDKEGEKPSFLDGPNQILFEVEAFEAINEHLARIDNCPVKNLKDLVEWNEQHPELAFHSPGQPDQQKELVATLARGGIRDEVYHHALAIAERVGQNVEATFAQLDVDVLVFPAPFACLASSIASSVGFPVATIPIGTFSTGQPCAINLLALKGQDEHVIAAMAAWDSVHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM78</accession>
    <name>A0A1Y1UM78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_649614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872157.1">
        <property type="nucleotide sequence ID" value="XM_022018020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM78"/>
    <dbReference type="FunCoup" id="A0A1Y1UM78">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM78"/>
    <dbReference type="GeneID" id="33559829"/>
    <dbReference type="InParanoid" id="A0A1Y1UM78"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="29128" checksum="C9F61E0BAD67703D" modified="2017-08-30" version="1">MATGAQSGGLPSDAVPISSGTLRETRLSSVDRALGSVIASLEKEQELKKAIREAMEPIEDISRRAASTLNDIHSVHGMDHRAIAQRTLDLIEQVRPLWTGVSTLIPAGEFYRYSFAVGPTLRTLTQLVAYAIFIIQDALAPSHDVARHLGVQEDSADGVILTADDYLQGVIGAINELPRLSVNAVTAGNYHLPLRIASFVNDVFASYSQLNLRNDVLRRKFDSLKYDLKKCEDVIYDLTLRGLNPRSADVSSAPVSRTSAPLGNTGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM79</accession>
    <name>A0A1Y1UM79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_618540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872972.1">
        <property type="nucleotide sequence ID" value="XM_022015044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM79"/>
    <dbReference type="GeneID" id="33556852"/>
    <dbReference type="InParanoid" id="A0A1Y1UM79"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41320" checksum="76E7A2392D306247" modified="2017-08-30" version="1">MTAPTLQHVKRLRQLPALSVVALRRYLSSLADPSKPLLPFIPKTVKIILLLLIIINSPSLPFQWHIRVWRYPLKAYFDLFTKGRDKFLGECEQRSLRHGGITERTRLKRIAWFDDCDYNLHLSNSCYAKNVDAARMKWAIDVILPAFRPGIHMALGATHYVFVKEIPLGSEYVMETRAGGWDEKWIYLVTEYIIYPKKAARGKGKRPIKPDPTPAGPSVPTLVGPSSTGDSTPEANGSSTPTTTMEAVRKAASLRSRMPREDGGIVCCLAVAEYCFKQGRVTVPPRIVLHLGMVSPNQSDRELARDRVLNSKDQGAKWVRGGWREEPDAMEIGASIGDEINGGDDKSFTSGWVEKSREGMEQVNAGLSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM93</accession>
    <name>A0A1Y1UM93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872177.1">
        <property type="nucleotide sequence ID" value="XM_022018024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM93"/>
    <dbReference type="GeneID" id="33559833"/>
    <dbReference type="InParanoid" id="A0A1Y1UM93"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012779099" evidence="1">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="163" mass="18094" checksum="3DE02A3B5BFF343C" modified="2017-08-30" version="1">MLQWHRSPLVLLAAFFFLSRARAKLSDPFVNLTEAPLPPLPHELQKRDGNYVKFAVEWPDKSLMEDNKENSRWWSDESWAGGWWYEAGHSANIPGAVVVNYYVNTQNDYMWKTGHATAQVTCTGGFTAPASGSTVTFTVAATSPYVRPTASNGAFFTCAPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM98</accession>
    <name>A0A1Y1UM98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_655395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872992.1">
        <property type="nucleotide sequence ID" value="XM_022018815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM98"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM98"/>
    <dbReference type="GeneID" id="33560624"/>
    <dbReference type="InParanoid" id="A0A1Y1UM98"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="411"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="246"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="348"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="508"/>
            <end position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="767" mass="83423" checksum="1221F9965F21BFB4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMB4</accession>
    <name>A0A1Y1UMB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytosine-purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_618648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873012.1">
        <property type="nucleotide sequence ID" value="XM_022015061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMB4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMB4"/>
    <dbReference type="GeneID" id="33556869"/>
    <dbReference type="InParanoid" id="A0A1Y1UMB4"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pur-cyt_permease"/>
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    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
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        <location>
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            <end position="447"/>
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    </feature>
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        <location>
            <begin position="468"/>
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        <location>
            <begin position="509"/>
            <end position="528"/>
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    </feature>
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            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="535" mass="58240" checksum="578976DCF4A6157A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMD4</accession>
    <name>A0A1Y1UMD4_9TREE</name>
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        <recommendedName>
            <fullName evidence="12">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_347823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="456"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
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        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
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        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="84144" checksum="3667148A2501DA07" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UML8</accession>
    <name>A0A1Y1UML8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872638.1">
        <property type="nucleotide sequence ID" value="XM_022015435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UML8"/>
    <dbReference type="GeneID" id="33557244"/>
    <dbReference type="InParanoid" id="A0A1Y1UML8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="505" mass="56607" checksum="C3C28BA2A9AC03AB" modified="2017-08-30" version="1">MARRHRDASSRQPTARFDPSTQDIADTYVPKHRSAKDQTSHGYSPGPRWFSNERTYDDTVNTASMPPYLHHGTDVTDKRPPTVYPSEGGTTVRPSSTLDDAAQIDTMLTMLNDIKRQVDSPIDTMTAEINTLRQSQEALRQQQLKILDQFTDVQRNLKNSLIAMRGKADPIGSRSWYQGSRSSGSSTSSGDESWHDDYPGYRPTGHHVNPSILITERTTPEETKPQWTKISVPAEGMQERISLVRVNDGPWKEQLEIWVRSDDPDITITLRLEDPSSDDQELGGRTKASRKEAHSPYPTRSVRFSGNVKHPQSSPSEWSDEQDAKTCRDTACRTPGCTGRNDSTVDTRLRTPGRSRSGSPVESSRARNRKAPYDGQDTPLGKGLADTNLSDVTIEGGTKRKRRPLVNRRDVEAKYDSSTLPDTQSPSYISRINNTAIKTSDSEPHRSTRRRRGRDITMSTQACTLLHEQRANQSCCLDAWPRPSGTRQTSLGANGNTRQQDRCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMU4</accession>
    <name>A0A1Y1UMU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_619422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873234.1">
        <property type="nucleotide sequence ID" value="XM_022015171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMU4"/>
    <dbReference type="GeneID" id="33556979"/>
    <dbReference type="InParanoid" id="A0A1Y1UMU4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="218" mass="24269" checksum="45E1A6A0DDCC04F1" modified="2017-08-30" version="1">MSATSSPVPTLMLQPPTPRAESSRRAVFENLPCIPFFESLDILDPMGSKPFDDEPTSPALDLNLLTPPGTPVRKHHRRRLHRKRYGHEHGASPSTPFTGIAIIGFIALLLLTSIASLSSPLAHLRHNNTASSRQTLFGRFRGRMNLVNALQSQSGVLDMTLSDMWTQVAIRKREIQLEAAAEPRGSGHVKAMSDNDWQQYRINARLPLPTAAMEFWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNY3</accession>
    <name>A0A1Y1UNY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_614856</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873536.1">
        <property type="nucleotide sequence ID" value="XM_022014652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNY3"/>
    <dbReference type="FunCoup" id="A0A1Y1UNY3">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNY3"/>
    <dbReference type="GeneID" id="33556460"/>
    <dbReference type="InParanoid" id="A0A1Y1UNY3"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892165" description="non-specific serine/threonine protein kinase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="670"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="18">
        <location>
            <begin position="980"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="551"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX39751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122726" checksum="E3C3BFF056ADA49A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP59</accession>
    <name>A0A1Y1UP59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_237997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873615.1">
        <property type="nucleotide sequence ID" value="XM_022012249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP59"/>
    <dbReference type="GeneID" id="33554057"/>
    <dbReference type="InParanoid" id="A0A1Y1UP59"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="111" mass="12342" checksum="9B3B6FA40926CC27" modified="2017-08-30" version="1">MRFLFLLCLNHPFQTMGSRLSFFNGRSSQTPSKMASHSISGDKFMGHSGRSGSAGGVHIEWRVHRDVNLCPILTHPSIYLYLNPSSPKRSINRRCVSATSSPKKKVPARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPL8</accession>
    <name>A0A1Y1UPL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_648612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873783.1">
        <property type="nucleotide sequence ID" value="XM_022017863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPL8"/>
    <dbReference type="FunCoup" id="A0A1Y1UPL8">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPL8"/>
    <dbReference type="GeneID" id="33559672"/>
    <dbReference type="InParanoid" id="A0A1Y1UPL8"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="118" mass="12836" checksum="CFDA325007DF4EA3" modified="2017-08-30" version="1">MRIRPIRREPKIDMSATFKSIRSVQPLLDRVLVQRFKAETKTSSGLFLPSSATQSPLPEATVIAVGPGSPDKSGVVQPVSVSVGDRVLLPGWGGNPIKVGEEEYHLFKDAEILAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ70</accession>
    <name>A0A1Y1UQ70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_261635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873934.1">
        <property type="nucleotide sequence ID" value="XM_022012314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ70"/>
    <dbReference type="GeneID" id="33554122"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ70"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="246" mass="27564" checksum="6F465DAEFDB5EB89" modified="2017-08-30" version="1">MKRIETREIKGSAGPGSIEEAWRDQSLWTHLSVEEAVIHDCTLRRHQSRLLIWSMMLLLSTVISLACVLGVESLPTWIDSRWSTVKECITDLKVVSCDDFDCGLEGYHRIDSFLNLSENTTVWNYVFYKSELDQDPGNCITDLRVVPEGEDCPTAPYWKSCGVSAHHGVTSTGGPTIWAQYEPGAQYAGEVVDLVVLRPGQYPDKTEDFIRQPVNLGLGSRAASASYPQWVEYESISSGWVWLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQC9</accession>
    <name>A0A1Y1UQC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_614674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873489.1">
        <property type="nucleotide sequence ID" value="XM_022014627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQC9"/>
    <dbReference type="FunCoup" id="A0A1Y1UQC9">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQC9"/>
    <dbReference type="GeneID" id="33556435"/>
    <dbReference type="InParanoid" id="A0A1Y1UQC9"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="288" mass="31202" checksum="BB821B4DFB68D2D9" modified="2017-08-30" version="1">MLRLTKLIRPTPLYTTLSHKTLNTFRAMSVFNTSRLEGKTVLITGASAGIGASTAKLFAKAGVANLILTARRADKLAEVKKECEGAGKVNVITVEADMTKREDINQILPKAGNIKVDILVNNAGMVYGREAIGDIADSDIDVMFSTNVIGLIHLTQILVREFKKQNSGMVINLGSIAGREPYAGGAIYCATKHAVMSFSHTLLRELVSTPIRVVEIQPGMVETEFSLVRFRGDKEAADAVYKGMEPLTGEDIAEEIVWCASRPPHVNIAQMLVLPVAQATATISHKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQG4</accession>
    <name>A0A1Y1UQG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_668370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874066.1">
        <property type="nucleotide sequence ID" value="XM_022018925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQG4"/>
    <dbReference type="GeneID" id="33560734"/>
    <dbReference type="InParanoid" id="A0A1Y1UQG4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="136" mass="14864" checksum="DFD18BA683857283" modified="2017-08-30" version="1">MSGQDTSTESGSKANSARSSQRQDTECPIDSGDEDVKDDEADDDASIKAISRSRTNKFPFETDEEDDGNVSDESVSSTRGIRRRYTGWGESQDPANETEEVHYAESDDEQAKITKTQLATEVQATEKSASDEVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQQ2</accession>
    <name>A0A1Y1UQQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_241798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873682.1">
        <property type="nucleotide sequence ID" value="XM_022012257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQQ2"/>
    <dbReference type="GeneID" id="33554065"/>
    <dbReference type="InParanoid" id="A0A1Y1UQQ2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="230" mass="25109" checksum="717336BDD058EC0E" modified="2017-08-30" version="1">MAASLHPPSLPPSPSAPANSQNPTSILRRASVAVSDTESERSLTFAIAAPRAEHSGPPLRLEVFEDSETPWEDSAAISTSEFPFARPTHYRGRQPGLTDEERLPRDQGCSRHRSPPPRARANSERPRRFIWQDKDQSSGGRRGSVPSILPTDHREPGQLQGRSTSLRLSPSQRALGKALQNYACPPTVDDTPVTARSMSPQVDDLCTRLGTLARGSPLELPRTVKRPSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQW0</accession>
    <name>A0A1Y1UQW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ loop repeat-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_648484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873649.1">
        <property type="nucleotide sequence ID" value="XM_022017848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQW0"/>
    <dbReference type="FunCoup" id="A0A1Y1UQW0">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="33559657"/>
    <dbReference type="InParanoid" id="A0A1Y1UQW0"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32173" checksum="6BE16118B3188525" modified="2017-08-30" version="1">MLKADPGIETALSTVGAVCWTVQIIPQVIKSYRTKSTLGLSAGLMAVWALASYPFSAYLVSQRLPIPLQVQPHAFGFLCGISWMQCLYYGYGYSKLKASLSFLLFLVVWAGFETGSVYGLWAAERHHIDAPSKVYGYVSAVMIAGALAPQYIEIYRLKQVIGISLTFMTIDILGGVFSFLSLFFRDKIDIAASVSYGLVVVLDGIVVILAFILNPIAKRREQQAAEQAQVTLNMDTPTTTTTSSGKEATETSHAHRTVSRDSIIHEAPQHFKWPENDGRSSTAVQEKHGEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQW3</accession>
    <name>A0A1Y1UQW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_237623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873611.1">
        <property type="nucleotide sequence ID" value="XM_022012247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQW3"/>
    <dbReference type="GeneID" id="33554055"/>
    <dbReference type="InParanoid" id="A0A1Y1UQW3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="151" mass="16905" checksum="5039795AC6644CF5" modified="2017-08-30" version="1">MNESSVSDQITCPARGNGQCPFQERPLILNNLYSSSSFTTARGKTTARDLNSGSSHWSYYIPQKRISRGFIECVSVLLYAIPQEVFRTLIEICVGFPWLGIFLGLTLYESAAVRMSPHLIHSTLPRLIQGTYHALMERSTFGPVLLATPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQX0</accession>
    <name>A0A1Y1UQX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_667355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873659.1">
        <property type="nucleotide sequence ID" value="XM_022018920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQX0"/>
    <dbReference type="FunCoup" id="A0A1Y1UQX0">
        <property type="interactions" value="795"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQX0"/>
    <dbReference type="GeneID" id="33560729"/>
    <dbReference type="InParanoid" id="A0A1Y1UQX0"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="268"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1072" mass="117132" checksum="34DE9AE2AD180914" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URJ0</accession>
    <name>A0A1Y1URJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal transducer</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_611705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874339.1">
        <property type="nucleotide sequence ID" value="XM_022014295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URJ0"/>
    <dbReference type="FunCoup" id="A0A1Y1URJ0">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URJ0"/>
    <dbReference type="GeneID" id="33556103"/>
    <dbReference type="InParanoid" id="A0A1Y1URJ0"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000160">
        <property type="entry name" value="Signal transducer, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="725"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="791"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="433"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="527"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="108551" checksum="F589B58E716B4423" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US85</accession>
    <name>A0A1Y1US85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_23944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874528.1">
        <property type="nucleotide sequence ID" value="XM_022012254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US85"/>
    <dbReference type="STRING" id="4999.A0A1Y1US85"/>
    <dbReference type="GeneID" id="33554062"/>
    <dbReference type="InParanoid" id="A0A1Y1US85"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="397"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="594" mass="63832" checksum="EE5D546E9B4A7425" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USP3</accession>
    <name>A0A1Y1USP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_677918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874125.1">
        <property type="nucleotide sequence ID" value="XM_022018960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USP3"/>
    <dbReference type="GeneID" id="33560769"/>
    <dbReference type="InParanoid" id="A0A1Y1USP3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="296" mass="32004" checksum="5668D3BF9013AA85" modified="2017-08-30" version="1">MNQSNNETTSAGTPTDLASGTANGEVEVNRWASPKLISHSDCSTEQVIADYFGTLHSQTTARVEQLQKSFGNLARVQGQEGAAANAIKTASADIAHFLEGVSQAHQESFTFSTENNDTLPGMFPLKPASAYLPSVPFGMRLATWIDDPLTASGTKCEDCTDLFCDAAELGKVVTKLSKEARTILEQAISAATQAVSAANLSQDTQEEINWSLASLYSQFVWTVSPQCRTLLMNTCSHGFGNYSIWVERMEKSAQLPNGDPTYPWPLEVAKIGMPARVIEDDQDAPGEPESDVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USQ6</accession>
    <name>A0A1Y1USQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_647947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874729.1">
        <property type="nucleotide sequence ID" value="XM_022017746.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USQ6"/>
    <dbReference type="GeneID" id="33559555"/>
    <dbReference type="InParanoid" id="A0A1Y1USQ6"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="820"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="889"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="972"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="535"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1316"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1328"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX41050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1373" mass="148142" checksum="B11286682C0A512E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USS8</accession>
    <name>A0A1Y1USS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_677950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874165.1">
        <property type="nucleotide sequence ID" value="XM_022018961.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1USS8"/>
    <dbReference type="GeneID" id="33560770"/>
    <dbReference type="InParanoid" id="A0A1Y1USS8"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000811">
        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="609"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="933" mass="99855" checksum="717C0E73D69DDE3E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT70</accession>
    <name>A0A1Y1UT70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874305.1">
        <property type="nucleotide sequence ID" value="XM_022014280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT70"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT70"/>
    <dbReference type="GeneID" id="33556088"/>
    <dbReference type="InParanoid" id="A0A1Y1UT70"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="594" mass="66873" checksum="21E6D203E96D2541" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTA4</accession>
    <name>A0A1Y1UTA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874927.1">
        <property type="nucleotide sequence ID" value="XM_022014537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTA4"/>
    <dbReference type="GeneID" id="33556345"/>
    <dbReference type="InParanoid" id="A0A1Y1UTA4"/>
    <dbReference type="OrthoDB" id="2586454at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58527" checksum="2F79E9F5960212F0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTC6</accession>
    <name>A0A1Y1UTC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_611744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874355.1">
        <property type="nucleotide sequence ID" value="XM_022014304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTC6"/>
    <dbReference type="FunCoup" id="A0A1Y1UTC6">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTC6"/>
    <dbReference type="GeneID" id="33556112"/>
    <dbReference type="InParanoid" id="A0A1Y1UTC6"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="31707" checksum="3CB344895EF63624" modified="2017-08-30" version="1">MGDSTSRLEPFILLARSTKGAAAEKVIQDATAATGVYTFTELLNLPNIQALVSDPSGSKSVKLLELFAFGTLETYRADESSYPPLTSAQLQKLKHLTLVSLALHHRSLSYSTLLTILELDSVRQLEELIIDSIYAELLTGKMHHHEQILHVDWVSGRDLRPEDLVHIQKGLETWCQTALTLVQALDDQIALVRQNAIEGMSEEQTYKEERMAMLESLMKTRGGGRQGLGPPGAGNGLDDQSDDVVMRATGAMAGLPSGKKTGLNRRGQGSAASSEELGRTRGSNKRLKDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UVF4</accession>
    <name>A0A1Y1UVF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_48491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874874.1">
        <property type="nucleotide sequence ID" value="XM_022012914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UVF4"/>
    <dbReference type="GeneID" id="33554722"/>
    <dbReference type="InParanoid" id="A0A1Y1UVF4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="218" mass="24661" checksum="36751D42383A04A5" modified="2017-08-30" version="1">MSILGVRRDHSPDKAPAHIRTASRLLSPNRRVKSSVRKSGKNTHTESHRVTQGALSGGNVARERLTGATILVIVRYTPKMNLGVARMPQMWYSRSWLILSIENCPTIRTHHYFRANSAPIPCLDPIPWRCIHANLRHFVPEAGRPEQISAGQGHNHVLLGTRISLWRISVRVPHMATVVGRLRHTQKNRYIMTYGVVLNANRRGALSLPHLSKVFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5U3</accession>
    <name>A0A1Y1U5U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867734.1">
        <property type="nucleotide sequence ID" value="XM_022017305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5U3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5U3"/>
    <dbReference type="GeneID" id="33559114"/>
    <dbReference type="InParanoid" id="A0A1Y1U5U3"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="55"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="21320" checksum="E04F47008DDC3ADF" modified="2017-08-30" version="1">MNRSVRATWTFRDIASGSASRFGPAPASLLALKSLDTEEDSTLAREWVKGFTVEDIPKSSYTATYSRSSGPGGQHVNTTDSKATVRMPIHRALGVWLPRYMTKGLIESSHFTHSSQSLLFSASLHRSAPANLTLVLSILHAHLVSVASSPIRGETSSAQRQRVDRLKARDRLKRYEAKERQKRDKSWRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6K1</accession>
    <name>A0A1Y1U6K1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867969.1">
        <property type="nucleotide sequence ID" value="XM_022017189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6K1"/>
    <dbReference type="GeneID" id="33558998"/>
    <dbReference type="InParanoid" id="A0A1Y1U6K1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="390" mass="43016" checksum="C59EA3F45DAE996E" modified="2017-08-30" version="1">MTTSMLSTYTPPSDPPATLEKLAEALHLLLAPEPLFNFLPTALTYLATFQQIAESVFSEASEALRLEQELVRELQDRQVPESRLDEHGCLSSDEVEVLEEMVLGGENGHYSVQLAELSLRFRLYHAAVFICSSAKVDQYAPIISEYFPSSLKKSPEGSVDDRFMRTKKFEAYAQRLATYQQTVHRWLNQAQGLKKSKLTAASLMISFDPTYHAGYIQGLVEHTLDFVAKVIQHVDELQALFPEDSAEGDASDDAEFSAADVLPEDDMMSAVGGNDPRHDEVPRHEHAGAVRRNPWEDDSSGQQPGEGPDRASKGPTASMTATPKHAGKPEQQDPPDYTAPSSGGKIGSRVDKSKLKPFSNSKLKRRSFPVPSTPGRSQTVVGTRENPMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7B9</accession>
    <name>A0A1Y1U7B9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_639736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867761.1">
        <property type="nucleotide sequence ID" value="XM_022017278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7B9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7B9"/>
    <dbReference type="GeneID" id="33559087"/>
    <dbReference type="InParanoid" id="A0A1Y1U7B9"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="574"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2415" evidence="4">
        <location>
            <begin position="677"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="784" mass="85883" checksum="B2AAA971C7396B17" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7H9</accession>
    <name>A0A1Y1U7H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_605359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868279.1">
        <property type="nucleotide sequence ID" value="XM_022014000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7H9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7H9"/>
    <dbReference type="GeneID" id="33555808"/>
    <dbReference type="InParanoid" id="A0A1Y1U7H9"/>
    <dbReference type="OrthoDB" id="2530165at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="41855" checksum="681FED259B3EA2E4" modified="2017-08-30" version="1">MPRPRRAAAPTSFIEPDIDISGEPFEAEQGADADFLALSSRQRTLIDRAFERGLKAAGKKQRREALKSRKRKRRETVVVDLTGDSGNELAGGSIEDDAGIGEGGFVDAGDDIGGGFVSQDGGGFVNEDDGGFVVDDDEDDDMKGGFVQELSRAEPVGPIDRLPLYILPGILTSLGLPADEDVLEVFRSSASGWEEANARERKNADDKQEGGGVELKDFRAVCAALMGNEGDGQNDEDLQGDDEEADQAFEIESSSSLSTLSDSDDEYGQPSVSSKGKGKGKGKASAGPGASLRRGKQKANMDLEEDQPIKLTSGQKEMVKSLWEMVKPNASGRGANILGRDEVKDLARGLSEMWSDEEITEMVSLFSTQHEGRGLSYDDFGKVMYRAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7J0</accession>
    <name>A0A1Y1U7J0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_187807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868288.1">
        <property type="nucleotide sequence ID" value="XM_022012128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7J0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7J0"/>
    <dbReference type="GeneID" id="33553936"/>
    <dbReference type="InParanoid" id="A0A1Y1U7J0"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="101"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="323" mass="35965" checksum="48B560C0AE3512C3" modified="2017-08-30" version="1">MSFIPSSWVPPCYDGPGMTKLRVGWHREHFLSPLLQFAEKDAGSTFELVECPGGTGEMQVKLKNGEIDICVALTDALIAGLANGLDSYKLVGRYIASPLRWAIITGKESKYNSVDDLKGTTFGISRQGSGSQVMASVLSMNQGWTADQQPKFKINGQFKPLRDSVNSGETSCFLWEWFTTKPYVDSGEVRFIGSVYSEQEDCPFQPDDTQAPWPCWSIAAAENSSTSSLSSFLSSLEPFVTHFNSPKAREKDDVDFVVDYFNHQREDVIEWLASVKWEEGLAQVEEKVIRDTLDTLEKAGVVKRPEAGWDMSTFVNADVCKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7N1</accession>
    <name>A0A1Y1U7N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_638044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868306.1">
        <property type="nucleotide sequence ID" value="XM_022017074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7N1"/>
    <dbReference type="FunCoup" id="A0A1Y1U7N1">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7N1"/>
    <dbReference type="GeneID" id="33558883"/>
    <dbReference type="InParanoid" id="A0A1Y1U7N1"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="266"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="366" mass="39939" checksum="98EF513019F94FDD" modified="2017-08-30" version="1">MAARPTITVWSAEGDSSGSLPLPAVFTAPIRLDVVQQVHKSMAKNRRQPYAVAENAGHQTSAESWGTGRAVARIPRVGGGGTQRSGQAAFGNMCRGGRMFAPTKTWRKWHVKINQNQKRYAVASAVAASALPSLVLARGHRIEQVQEVPLVVSSSVQGINKTKAAVELLKTLAAYPDITKVSNSRKTRAGKGKMRNRRYRQRRGPLVVYDKDEGIVRAVKNIPGVETCPVDALNLLQLAPGGHVGRFVIWTEGAVKALDGIYENKSGFNLPHAKVTSSDVTRIINSDEIQSIVRPKGQAVAKRPFTQKKNPLRNKAVLFRLNPYAKTLRRQELIRQERKKAGKGSVKKSVPAGTASKQFLDILHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Q2</accession>
    <name>A0A1Y1U7Q2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_654030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867893.1">
        <property type="nucleotide sequence ID" value="XM_022018739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Q2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Q2"/>
    <dbReference type="GeneID" id="33560548"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Q2"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF10">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="331" mass="36578" checksum="30807B16D8CFF680" modified="2017-08-30" version="1">MAHNGHQAHITAPSLKQHRTYASSAAVRGDYYTVLKVSRGATKQQIKAKFYELSKRFHPDASGGSVEKFHAIGEAYEVLGDELKRRVFFWLKSPAERRSLREYDQTLIQPKYTSYQHPSSSSSYSQQTSYTRRPAGPHMAWSGSGRSSKPNSSSSSSSSSSSSSSFLYRPSGSRDPFGSPSPEPGEYGAPLFGKGYQPYRKYDSRYSTAGDYGESLYSDMDPSASTNQSSKKGKRRKNAESRQDEAADLDQLRSAAIRDPWNSKYQALKDVWFDQAKTGRFTTGSSENESRPSPNGILGLLVVTCFAGFFWLASGSAKADEGDQHETGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U815</accession>
    <name>A0A1Y1U815_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_168649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868457.1">
        <property type="nucleotide sequence ID" value="XM_022012081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U815"/>
    <dbReference type="GeneID" id="33553889"/>
    <dbReference type="InParanoid" id="A0A1Y1U815"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="87" mass="9619" checksum="2C06EABE4660F414" modified="2017-08-30" version="1">MQSLFMSSAMSADAGPSSNWTKLKLTLDAQSRDKGKEKETRFYEGKSKKRKALKGVAAYVRGPAEPTSVERGDGHVPYLFIHSKVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U867</accession>
    <name>A0A1Y1U867_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_583806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868486.1">
        <property type="nucleotide sequence ID" value="XM_022013638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U867"/>
    <dbReference type="STRING" id="4999.A0A1Y1U867"/>
    <dbReference type="GeneID" id="33555446"/>
    <dbReference type="InParanoid" id="A0A1Y1U867"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="420" mass="47023" checksum="769E03D121C6DF3B" modified="2017-08-30" version="1">MEIYAPKLHLIEVQSEKRRINVAGSSQPGRYRLDLAWEDDDPGSLIAVHLRDDDGGFAVVTTPVRPSRHCNVHGWDSVAVKIVGQSPTGKLRFCAYRLLATQTQGRDTLLVLSQPPSSDFMALLPDSTALGSVAMAGTHETLAFFGGPISQCQQPATGLYEQLESGIRFIDVRLKVVGTQLIAYHGPQSQRLDFPTILSTIHRFLQSHSGETLIMSIKEEIPPFHPRFSALVERDLTVFNDDWFLENRVPTLGEIRGKAILLSRFERVEEKEWLNGLGMHPASWPDSKPYVFEWDCSGTRVRVQDWYRVGSFIQIPEKYRIVVESLDPSLDAQLKDPSFTLSFASASNFPLALPTTMAKGFGWPSWGVGVRGINSRLSYWLLERICAGQKVKACILFDFYRQTGESDADLASIMTAMNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U876</accession>
    <name>A0A1Y1U876_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_637144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868496.1">
        <property type="nucleotide sequence ID" value="XM_022016971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U876"/>
    <dbReference type="STRING" id="4999.A0A1Y1U876"/>
    <dbReference type="GeneID" id="33558780"/>
    <dbReference type="InParanoid" id="A0A1Y1U876"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51-like C-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="381" mass="41550" checksum="4F36E904A4403666" modified="2017-08-30" version="1">MLLKRISGRLPPYLADLIPILETADIRTTENVMFTHESTLNSLFPAIPRHLLDLLRAHCLDATAPSFRDGTESPMAVSSNGVDRVWRGWGPEELDKLLMDWDGIGILEIAGPRRAGKSLLALHAALKVLVKDSQATCVWIDTSGSFDPQRAKSILSLDSTENIEGVLNRLVVMRCFSVEPDMHEAFGKIEASLEDSSENTDQPRVKVIVIDSITNLFKDALMPTTSQGHAAMISLMADLASDLTYKYGLLTMITNSTASALPFNPLSNFSVTTLKPALGTAFTYHSDISLLVQETGKIFGMIDPDERDRVRAAPGLRGVVEVIKSRVTPSGSWAVFETNGVSLLNVVAPSQEDIRTLRMSAGLPTGQQRPLMGPLRETLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U888</accession>
    <name>A0A1Y1U888_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_605080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868527.1">
        <property type="nucleotide sequence ID" value="XM_022013993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U888"/>
    <dbReference type="STRING" id="4999.A0A1Y1U888"/>
    <dbReference type="GeneID" id="33555801"/>
    <dbReference type="InParanoid" id="A0A1Y1U888"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="427"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="628"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="935"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1195"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="974"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1195"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1260" mass="138217" checksum="049F72E472B588EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8N7</accession>
    <name>A0A1Y1U8N7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Flap endonuclease 1</fullName>
            <shortName evidence="13">FEN-1</shortName>
            <ecNumber evidence="13">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_635698</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
            <location evidence="13">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
            <location evidence="13">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="13">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="13"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868664.1">
        <property type="nucleotide sequence ID" value="XM_022016834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8N7"/>
    <dbReference type="FunCoup" id="A0A1Y1U8N7">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8N7"/>
    <dbReference type="GeneID" id="33558643"/>
    <dbReference type="InParanoid" id="A0A1Y1U8N7"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="272"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="449" mass="49555" checksum="BD3765D3A394C1C2" modified="2017-08-30" version="1">MGIKGLTGLLSEHAPRAMRDHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVEHGIKPCYIFDGKPPDLKSRTLAKRFERREEAKAGEEEAKETGTAEDIDRLARRQVRVTKEHNDECKKLLALMGIPVVTAPGEAEAQCAELARAGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEIHLQTALEDLKMTMDQFIELCILLGCDYLEPCKGIGPKTALKLLREHGGLGNVVDFVRGKMAEKAHDNAEAIAQQSESEDEPIHSDRESEEGGGGDWGEESGGPSSSPMKKKPAAPAKSPKKKKVTSAGMQIPEFWPWEEAKKVFLKPDVVKGEDLELDWKVPDTDGLVDFLCRDKGFNEDRVRAGAAKLAKMITAKQQGRLDGFFTVKPKEPEANGKKAGDKRKGGAVEKDKGGAKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U982</accession>
    <name>A0A1Y1U982_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_638251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868354.1">
        <property type="nucleotide sequence ID" value="XM_022017095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U982"/>
    <dbReference type="STRING" id="4999.A0A1Y1U982"/>
    <dbReference type="GeneID" id="33558904"/>
    <dbReference type="InParanoid" id="A0A1Y1U982"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="223" mass="24299" checksum="89CE18C688D82775" modified="2017-08-30" version="1">MGLPHLTRLERFLVSPRPIGSPWLNGPSAGFHWTPRADRSKHRGSLDVYSRYRASVRPPIAGTDIFETASTVPAGTSLQEIPKDASTRWQAPIPAMKSVPPIVAQEISSSTSEGITIEGIHVPVKPRRPGEEECCMSGCAYCVYDIYAEELEAYNEAVRETRSKLEAKSVPPSDWPQAVRPSETGSGRVAVEEEVVDPSMSAFLALEMKLRKKQAPTGNGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U984</accession>
    <name>A0A1Y1U984_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_636537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868852.1">
        <property type="nucleotide sequence ID" value="XM_022016905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U984"/>
    <dbReference type="STRING" id="4999.A0A1Y1U984"/>
    <dbReference type="GeneID" id="33558714"/>
    <dbReference type="InParanoid" id="A0A1Y1U984"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="203" mass="22828" checksum="1760CBD26804C111" modified="2017-08-30" version="1">MSENQQFFETITKSYVDVPITEDGVDTAAFCEASENLVKIFGLFGNPAFSVVVNDLTGNIAKIRKFLAANPESAKTLESLLATDKAQHPKEKDRDTTSGLMWLLRGLKFTAVGLRSNLQNPEEELSTSFTKGYEASLKKWHGMMIRPVFYLAMKACPYRATFYPKLGSPEDVVKVKMEEWLTALENIVAHMEKVFRDGKYGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U993</accession>
    <name>A0A1Y1U993_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TB2/DP1, HVA22 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868862.1">
        <property type="nucleotide sequence ID" value="XM_022018648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U993"/>
    <dbReference type="GeneID" id="33560457"/>
    <dbReference type="InParanoid" id="A0A1Y1U993"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48189" checksum="13B2B09BE80B2233" modified="2017-08-30" version="1">MSYQPISTRIVQYVLAPTYQSQSVTCSIIQATAKKIHRPPHVLQNAVVLLVGSILVLNVNGCGPLLSQIITFLPAVWGTLKYIRAEAMEHRRGGTLPPVDLTHIQRKWIDYWIIFSGIVMAESWVDEWHIDRCFPLWWATKVGTLFWILAKRSNPKPAHHEAHGSEKGKTRPKPLSLQEHQNSKRKMRKAAIRPPTPIANSALLVRSHEALPISAITPPEAEAHLAARLPMTIARSIVPHPIKQVNVSKSPPVGPQPVDLVISPTPLVPAHLSVGSVDVEGTVQEPPRIGMDSPPFELSVDDEGSYHSESAKRLKLPEGGLYFDNLSADMDSAPSDYDENVVYNISPQARLTPSLNGTQSSADAKKAMGSTDFTRTAEEPGRAARYSVPSLHKLLESASEQEAPSDPTMIGSGLADFEGTEPLSLFERRVRRQISTGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9C8</accession>
    <name>A0A1Y1U9C8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_634310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868883.1">
        <property type="nucleotide sequence ID" value="XM_022016712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9C8"/>
    <dbReference type="FunCoup" id="A0A1Y1U9C8">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9C8"/>
    <dbReference type="GeneID" id="33558521"/>
    <dbReference type="InParanoid" id="A0A1Y1U9C8"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="611"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="634"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="714"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="745" mass="82584" checksum="858335442D126860" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9M8</accession>
    <name>A0A1Y1U9M8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_130539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868982.1">
        <property type="nucleotide sequence ID" value="XM_022011987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9M8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9M8"/>
    <dbReference type="GeneID" id="33553795"/>
    <dbReference type="InParanoid" id="A0A1Y1U9M8"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="282" mass="31655" checksum="9C49E95368291888" modified="2017-08-30" version="1">MGVEQNGKTVVLKHDSGASVEVYLFGATVTSWKVDGEEKFFLSSKSSLDSSKPIRGGIPIVFPIFGAPPSSPPEYAALKQHGFARTADWSVDKVIMDRPEGVSVRFVAPPPPSEFKHSYKLAFVVTLAAHQLSTDLHIINEGKEEFQFQALLHNYLAVPDAKKLSVEGIDKGTRYKDKTQNFKELIWPGEPLTITQETDAVFQKLETQELKLDYGNGKGLNVRFRGFEDCTIWNPQEKGKTMADMEDGGWERYICIEPGFVREFKYLQPGEEFLGQQVLTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Q2</accession>
    <name>A0A1Y1U9Q2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_657960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868515.1">
        <property type="nucleotide sequence ID" value="XM_022018874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Q2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Q2"/>
    <dbReference type="GeneID" id="33560683"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Q2"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="347" mass="39520" checksum="D46DFF8BDBE02C47" modified="2017-08-30" version="1">MSATQHKKPRIILGLMTFGPDKEKGARVTSMDDFNKILDDLQKLGYNEVDTAYSYCGTEQQAWTRKANWKERDLKLATKFYPGGQGGGHDAANIRAKLEWNLEQLGTDCVDIFYLHAADRNTPFVETLEECNKLHKEGKFKQLGISNFTAYELAECVTICQERGWVKPSIYQGMYNAITRNLESELIVACHRYGLEIVVYNPLAGGLFSGKIKSKDQKVEDPHSRFGAQASTGSNYRKRYFRDATFESLEIIEKVADKHNLTLLEIALRWTVHHSKLHIDNGKDGIIIGVSSVDQLESNIKDLEKGPLPEEVVQVIDEAWLHVKAVSPVYWHGELEYGYDWDNTYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAB5</accession>
    <name>A0A1Y1UAB5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_150538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868699.1">
        <property type="nucleotide sequence ID" value="XM_022012023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAB5"/>
    <dbReference type="FunCoup" id="A0A1Y1UAB5">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAB5"/>
    <dbReference type="GeneID" id="33553831"/>
    <dbReference type="InParanoid" id="A0A1Y1UAB5"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="359"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="435" mass="47102" checksum="2BC8CFE1481C0855" modified="2017-08-30" version="1">MVNESETNKVDFFAYNQFSARDLPVPRFGKPQLITGGVSKPVRSIAWSCDGKRLATGTEFKGLRIWETRTSSPSSSRPTPHNGHIASLAFSPVDPNILVSGCKSSSAGAVVAVWDLTSPKEAIATFNISGDVLHLAFHPSGQHFAVVCPRSNRDEVFFYHLTERDGTQVWAMREDIGMGGPGVDIGFEEINSLRFSNSGKLVCAVSNDGSINAWAYPQRPRQLKLDEPLDNVGAGKGAAETLGSTPRSGTPDRDEGEKPPAENDVEMADDSAAQADPVEADGKAMAPVQLATLSAQEIEQEKKRARQLQRLRHAVCHSASLLALAFDPLGRFLAAGGQDALLSLLDTREWICQRTFDACTGAIRHLAFSPDGELIAIGGDDNYIAVVSIFSGQTIAKLLFSGAVMALCWHPKKNWLAWSVTGKSTMPQWYVAYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ9</accession>
    <name>A0A1Y1UAJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_643173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869284.1">
        <property type="nucleotide sequence ID" value="XM_022017529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ9"/>
    <dbReference type="FunCoup" id="A0A1Y1UAJ9">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAJ9"/>
    <dbReference type="GeneID" id="33559338"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ9"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="320" mass="35812" checksum="CF6E4368FC968B16" modified="2017-08-30" version="1">MSNPPPSSGASGPTLRVKTPRFAHHNVAFSPFFEDKIATASGANFGLVGNGRLHILQMGPGGLQVVKWFDTQDCVYDVAWNECHENQVIAGCGNGSLKLFDTTLNDFPIKAWHEHSAEIMSVDWSNIQKDTFASSSWDHTVKIWRLSRVTSMATIPAHQGQAYAAQWSPRQSDTIATCGQDGFLHVFDLRAQEMRPMSSVKVSETDLLSCDWNKYDSLLATGGKDSTITIWDTRQMARPVGQLGGHALAVRKVAWSPHHRDVIASTSYDMTCRTWNTSTRSERRVHHDHTEFTMGCAWALFERDLIADCSWDEEVHVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAW7</accession>
    <name>A0A1Y1UAW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_125217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868899.1">
        <property type="nucleotide sequence ID" value="XM_022011971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAW7"/>
    <dbReference type="GeneID" id="33553779"/>
    <dbReference type="InParanoid" id="A0A1Y1UAW7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012192156" evidence="2">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="216" mass="23657" checksum="DD79F37DEFABE87B" modified="2017-08-30" version="1">MIYTISTLSLFSIFVYAQDAYLAAQKSQATTFVSSDGVEVFTKPVYVSDSELHWLSVDDYSTVWYCTQYGDSEGSMRWYSPTIFMGPTLNDSNPTIAYSSSSIEFGCGVGLPMTDGIFDHIHSEAGECLAVSLYSCAAEDDDDDDDDAPEGCQGHSTQDIGFMPSSSSEAQHFFENQNDCVDRCHPYTRHEGVGCPFCPGPECQRCPGCSSPYDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB93</accession>
    <name>A0A1Y1UB93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_683225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869029.1">
        <property type="nucleotide sequence ID" value="XM_022019177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB93"/>
    <dbReference type="FunCoup" id="A0A1Y1UB93">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB93"/>
    <dbReference type="GeneID" id="33560986"/>
    <dbReference type="InParanoid" id="A0A1Y1UB93"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="86" mass="9244" checksum="8EE0D685A678F083" modified="2017-08-30" version="1">MPGTGKMAAQQGYQPAVLYKLLIFALLMAIAPIATYFASLHYIWKGSTIAAAISAVMVANAVLVGYVVVAFREDPPDPITMDKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBA4</accession>
    <name>A0A1Y1UBA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_88063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869482.1">
        <property type="nucleotide sequence ID" value="XM_022019272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBA4"/>
    <dbReference type="GeneID" id="33561081"/>
    <dbReference type="InParanoid" id="A0A1Y1UBA4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="175" mass="19782" checksum="930FF08604D96BC0" modified="2017-08-30" version="1">MLRWCRWHDRKGDDDYRAVSKKKKDLTTTGFCIMGPSMDFRRPYEDTVVRVYSCIEDSDKIAVWQPNQKPKWSLNRSEAVPRSRMTFNRLSKLGGFRVSKGVIRKAHGINIRSCDGYATRPLEGAADQLLHEHGGVTVAEYVSLIHPPSPREKKLTAPSFGSARSCRLHSCASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBG1</accession>
    <name>A0A1Y1UBG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_653112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869099.1">
        <property type="nucleotide sequence ID" value="XM_022018610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBG1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBG1"/>
    <dbReference type="GeneID" id="33560419"/>
    <dbReference type="InParanoid" id="A0A1Y1UBG1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="9"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="331" mass="35791" checksum="5C893D2251F38130" modified="2017-08-30" version="1">MPTFTVFKGSKDGAIVKSSTTKSDDLEGDQVLVKITASGLCYTDLHYKTQDMVLGHEGIGRVEAIGPKVKELTVGDRVGWGYEHDCCGGCKHCLTGWETFCPDRAMYAEADLDQGSFASQAVWKETFLFKIPDSLSDVDAAPLQCAGSTVFNALQGVGSSDVVAVMGVGGLGHLALQFAAKLGCRVVAISGSDSKRDEAMKLGAHEFIATKNAKELKVEKKITRLIVTTSAQPDWEKLLPILDRQAGIYPLSVDPGKFELPYMPLLVNGIKVQGGIVGTRAVHRNMLDFAGQHDIKPVTETFPLNEKGIKEAMSKLEAGEVRYRAVLLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBG3</accession>
    <name>A0A1Y1UBG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EFM4</name>
        <name evidence="6" type="ORF">BD324DRAFT_635196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBG3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBG3"/>
    <dbReference type="InParanoid" id="A0A1Y1UBG3"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24007">
        <property type="entry name" value="ASKHA_NBD_eukNAGK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="613" mass="65343" checksum="25073DFF0E74CA93" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCJ7</accession>
    <name>A0A1Y1UCJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_563768</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869934.1">
        <property type="nucleotide sequence ID" value="XM_022013028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCJ7"/>
    <dbReference type="FunCoup" id="A0A1Y1UCJ7">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCJ7"/>
    <dbReference type="GeneID" id="33554836"/>
    <dbReference type="InParanoid" id="A0A1Y1UCJ7"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="207" mass="23475" checksum="396FE824C7217C1B" modified="2017-08-30" version="1" fragment="single">MAQVVACLEQPSSYRDHRSEVNRETERKLLSLSSTLYVGNLSFYTTEAQIYELFSHCALPGKGGGVKRIIMGLDRNQKTPCGFAFVEYYLHEEAVACLRCISGTKLDERVIRCDLDPGYKEGRQFGRGKSGGQVRDEFRQEYDSGRGGWGHQRLEEERRRQEQDRLRSRVQFDTYASSMGGLGMSGADVPRGETDVARSKRSRSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCK5</accession>
    <name>A0A1Y1UCK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_79500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869945.1">
        <property type="nucleotide sequence ID" value="XM_022019248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCK5"/>
    <dbReference type="GeneID" id="33561057"/>
    <dbReference type="InParanoid" id="A0A1Y1UCK5"/>
    <dbReference type="OrthoDB" id="2447764at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="302" mass="34446" checksum="DF91ADD4CC05BD71" modified="2017-08-30" version="1">MARLKTAYSASVVSDVIPNDVDSSHLTSADTASSSRPTRSPTRKRLSYIPPSEQVFEVSRILARSLHTSKCADGTRQHHYLVKWEGYGPGSDSWEPRSNLVPGANAFLTAYDSKEQQFVILQSRKGKSCSYLVRYGCIQVGLQRLEPSPLYEEEWQTRDQMMEIGQLSEWTIDLAIQAFHGKNFDPVIARATSSAARNQTPALKVVESVSLKTRRKVRHPMDLFKVRWTQKQNLCEAWYSRYQLSRRFQAQDLKDAIQKYREESQTLPPVEPSTPGSEYESERQKNIEQNKDLLKELGLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCT1</accession>
    <name>A0A1Y1UCT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-coenzyme A transporter 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_632313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869506.1">
        <property type="nucleotide sequence ID" value="XM_022016510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCT1"/>
    <dbReference type="FunCoup" id="A0A1Y1UCT1">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCT1"/>
    <dbReference type="GeneID" id="33558319"/>
    <dbReference type="InParanoid" id="A0A1Y1UCT1"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="667" mass="73345" checksum="7E18AE266578633D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCZ9</accession>
    <name>A0A1Y1UCZ9_9TREE</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869586.1">
        <property type="nucleotide sequence ID" value="XM_022016539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCZ9"/>
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        <property type="interactions" value="75"/>
    </dbReference>
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    <dbReference type="GeneID" id="33558348"/>
    <dbReference type="InParanoid" id="A0A1Y1UCZ9"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="345"/>
        </location>
    </feature>
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            <end position="132"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="310"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD11</accession>
    <name>A0A1Y1UD11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870042.1">
        <property type="nucleotide sequence ID" value="XM_022016217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD11"/>
    <dbReference type="GeneID" id="33558026"/>
    <dbReference type="InParanoid" id="A0A1Y1UD11"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010984729" evidence="2">
        <location>
            <begin position="23"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="589" mass="57385" checksum="BF328B7045C38723" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDD5</accession>
    <name>A0A1Y1UDD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_581517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870179.1">
        <property type="nucleotide sequence ID" value="XM_022013509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDD5"/>
    <dbReference type="GeneID" id="33555317"/>
    <dbReference type="InParanoid" id="A0A1Y1UDD5"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="339" mass="35646" checksum="C5A3B79FC532ABA6" modified="2017-08-30" version="1">MTFSPLHTFAGGTLLSLASSSFLSDIGRVFGISSIVAESFWGDGDSWRLATTAGLIFGPTLGKVFGLPGAYASEPLSGWFSIPWTRASLAGLLVGFGSRLGSGCTSGHFLCGVSRGSPRSLVATATFFLSAVLTANLVPMETPYPSWIPKPNPFTIQTGLAYAPLITVPILAGLVFTLRSTLARSGSNPPRIIRLAPYFLAGLTFSFGLLISGMADPRKVLHFLTPFSPRFDPSLAMIVLGGVVPNALYWNYTPKGKVQYPWEEWRIPTRTDIDRRLMAGSMIFGIGWGLAGVCPGPAIVGIGKIVQGIISGEDIGGPGAPLLAFILSMIMGMGAGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDX4</accession>
    <name>A0A1Y1UDX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_628026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870339.1">
        <property type="nucleotide sequence ID" value="XM_022016071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDX4"/>
    <dbReference type="FunCoup" id="A0A1Y1UDX4">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDX4"/>
    <dbReference type="GeneID" id="33557880"/>
    <dbReference type="InParanoid" id="A0A1Y1UDX4"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="201" mass="23617" checksum="93D368A063060A2D" modified="2017-08-30" version="1">MGAYKYLSELYTKKQSDVLQFVSRVRCWEYRQLAVCHRASRPSRPDKARRLGYKAKQGYLIYRIRVRRGNRKRPAPKGATYGKPVRQGIAQLKPQRGLKATAEERVGRRCGNLRVLNSYWVNQDGVYKYFEVILVDPSHKAIRRDPRINWICNPVHKHRESRGLTAEGKRNRGLGKGSKYNHTPARATWRKHNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEA5</accession>
    <name>A0A1Y1UEA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_632704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869595.1">
        <property type="nucleotide sequence ID" value="XM_022016545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEA5"/>
    <dbReference type="FunCoup" id="A0A1Y1UEA5">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEA5"/>
    <dbReference type="GeneID" id="33558354"/>
    <dbReference type="InParanoid" id="A0A1Y1UEA5"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013208776" evidence="7">
        <location>
            <begin position="24"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="398" mass="42277" checksum="FC755C4CBECCBBCE" modified="2017-08-30" version="1">MKIMRSSVKLCLILGIAGALALAKQQGQAVFSVPKTLSTHQHGMSMKEVFGVLFPFKSPAYNSVLATFYISSAPNLILLAVPSDLDPSSLNTMIAFATGGLLGDVFLHLVPHAFFGECHDEGHEHHRAIVVEEKRNIVVGASIFLGFMAFFMLDKTMRVLSASSGDETPGHGHGHGHSHSHSHSHSHSHATSSGSSSAVKGDNDLRQRKSTKEVSSSVVSAPQDQPKVNPSLKLSAWLNLFGDFTHNITDGLAMAASFYSSPALGAVTTIATFCHEIPHEIADYSILIKSGFTKSQALGSQFFTALGAFLGTFLGIWIAETSGAAHHTKLPIGQGFFGTSVGASELVIPMTAGGFLYIASVSVVPELLAESRSATQALKEYSAMAFGVFCMAVIAWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEB3</accession>
    <name>A0A1Y1UEB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_628636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870484.1">
        <property type="nucleotide sequence ID" value="XM_022016130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEB3"/>
    <dbReference type="FunCoup" id="A0A1Y1UEB3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEB3"/>
    <dbReference type="GeneID" id="33557939"/>
    <dbReference type="InParanoid" id="A0A1Y1UEB3"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="556"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127424" checksum="80D53FDA9C1E3619" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEH5</accession>
    <name>A0A1Y1UEH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_580830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870561.1">
        <property type="nucleotide sequence ID" value="XM_022013468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEH5"/>
    <dbReference type="FunCoup" id="A0A1Y1UEH5">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEH5"/>
    <dbReference type="GeneID" id="33555276"/>
    <dbReference type="InParanoid" id="A0A1Y1UEH5"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013390674" evidence="7">
        <location>
            <begin position="20"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="148"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="572" mass="63752" checksum="A81AD8F989ACD394" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UER0</accession>
    <name>A0A1Y1UER0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_60177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869719.1">
        <property type="nucleotide sequence ID" value="XM_022013935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UER0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UER0"/>
    <dbReference type="GeneID" id="33555743"/>
    <dbReference type="InParanoid" id="A0A1Y1UER0"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="22270" checksum="B599E773B2359980" modified="2017-08-30" version="1">MTIPSLDRYIAMDCETVRTRAGHVLAKVGMVDHFGTEIYQSYVFVDRRNVTDWITRVHGIKPGDLDDAPRFQEVQAKIKEILKDKILVGHAVFNDLSWVQHRHPYEDVRDTCLYYPLRKSIGVEREGEYPGLKKLYLKAFGEEIQKDIHCPVEDARAAMRLFMSVRKEFEQSLAAGEDCISGMPAAYQKWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEU5</accession>
    <name>A0A1Y1UEU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ClpP/crotonase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_626392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870649.1">
        <property type="nucleotide sequence ID" value="XM_022015891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEU5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEU5"/>
    <dbReference type="GeneID" id="33557700"/>
    <dbReference type="InParanoid" id="A0A1Y1UEU5"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="312" mass="33844" checksum="648CEE38A3B7A2FC" modified="2017-08-30" version="1">MLWTLSRASRLLRPSCTKSLPGPVLRTAPLSRNLQTTSTASPPPHAYLEPLDLKNHEKPEELEGAMCLVMNREKARNALSVQMVHEMREGIAKVNASTSARLLLLHTPFTGMFCAGADLRERATMSQTQVSDFLNALRSMMQELEGLSVPTISVVDGFAMGGGTELALSCDLRVGGPKTTMALPETKLGIIPGAGGTQRLTRLVGVAKAKELIYTGRRIEGIEAERIGLVNLLAREPSSAWDAALALSRQILTSAPLALRAAKMAIDSAVDLPLEQGLDMERKAYATLLDSEDRKEGLRAFAEKRRAKFQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF15</accession>
    <name>A0A1Y1UF15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_455610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870681.1">
        <property type="nucleotide sequence ID" value="XM_022012832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF15"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF15"/>
    <dbReference type="GeneID" id="33554640"/>
    <dbReference type="InParanoid" id="A0A1Y1UF15"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="1">
        <location>
            <begin position="159"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="392" mass="43407" checksum="FBEEB0D6456C9A45" modified="2017-08-30" version="1">MTMSNKFNVLILGAGRINFGSTEASWAHSLRLEKKLGPALNVVGLVDINVAYAEKIIASKRAIEGLVGYEHTKVFKTVADAEAGLSEEEMPKLVVNGLPANYRGTTIPNHDLDVQVAKLFPTAAQFIEKPISAGSLDDVTQANEELQKGGLTSVGYMLRYLQAVTEMKKIIAENNLTVMCTQATYLMAYKYAGLRDESIDYWDMNGELGPIVGQGTHLVDLSRYFCPDPVHDSIRVHTVEASDKPGKLSQLTIKAESELPADRKIPRITNAIWRYESGATGSIIHGTCIHEGDYDCELVVLADGWKLRLVDPYGVAPRLYVRRPGTTSETMTEFKNDDPYYNEFSDLVDVIQGKANQSAVRSTFTDAMKTYKFTWAIRWAGEVEARARGARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF95</accession>
    <name>A0A1Y1UF95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_642450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870308.1">
        <property type="nucleotide sequence ID" value="XM_022017486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF95"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF95"/>
    <dbReference type="GeneID" id="33559295"/>
    <dbReference type="InParanoid" id="A0A1Y1UF95"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="34910" checksum="86CEA292DD761A6C" modified="2017-08-30" version="1">MSGSSSQAPTNVRSGRALFRLCLVRDDIRLVAINHTALSLEHLFNAIRHDSTHGPCIAARDLPLEYHGRVIHLFSQRDPHKLDWKLAGAEYIFESTGKMTREAQARVHIDHGGAKKVVISAPSSDCPNVVFGVNHRTYQTDQDVLSNASCTTNCLAPIALVLHRSFGIETGMMTTVHASTSSQKVLDGFSTKDVRQGRSAMGNIIPASTGAAKAVVKVLPELAGRFHGISIRVPVTNVSLVDLTVTLETPVASKDDLISVFRHAATPRLAGIVAVSDEKLVSSDYLSSTESATIDVDASVALDGRTVKIVAWYDNEVGFSSRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFF3</accession>
    <name>A0A1Y1UFF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Noc2p family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_591498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022013801.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="33555609"/>
    <dbReference type="InParanoid" id="A0A1Y1UFF3"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="811" mass="91820" checksum="05F7B74400C8DB84" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFJ2</accession>
    <name>A0A1Y1UFJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_627244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022015983.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFJ2"/>
    <dbReference type="GeneID" id="33557792"/>
    <dbReference type="InParanoid" id="A0A1Y1UFJ2"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="187"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="364"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="818" mass="91133" checksum="46D19EF92D96BBCB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFM3</accession>
    <name>A0A1Y1UFM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_470459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870887.1">
        <property type="nucleotide sequence ID" value="XM_022012876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFM3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFM3"/>
    <dbReference type="GeneID" id="33554684"/>
    <dbReference type="InParanoid" id="A0A1Y1UFM3"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="349" mass="37811" checksum="4EF56B4F966A71FF" modified="2017-08-30" version="1">MRAFQVKKLAHPRDITLSDDVPPPIAQKSQVIVDVYATGLNFFDVLQAQGKYQNRPPLPFILGAELAGRIAEDSPIPKGCPFQPGGGGNTDRVHGFGAGAYAEQVASAVIPLTYTTSYDGLVHRGQMKENEWVLVHAGAGGVGLAACQIAKVLGAKVIATASTEEKRRICRDKARVDAVVDYTQTGWQKEVMKITSGNGVDIVYDPVGMIIPSLKCVNWNARIVVVGFAAGTIEKVPANLLLLKQVSIVGLFWGGGTERDPRHAAEVVLSLSKLFSSGRLKPILYEPIYEGLESVSKALTDLDERKIWGKGVVRVMKEQSDSHPRVKPCFECPSFVLCLAWTKDGTKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFQ8</accession>
    <name>A0A1Y1UFQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_580941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870447.1">
        <property type="nucleotide sequence ID" value="XM_022013474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFQ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFQ8"/>
    <dbReference type="GeneID" id="33555282"/>
    <dbReference type="InParanoid" id="A0A1Y1UFQ8"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="464" mass="52499" checksum="3BD4086B2027A086" modified="2017-08-30" version="1">MSTSILPRSSSIPSPLAASSSSSTKLLHPDLFTRPHKLLSRTRSASPSPSICSAATSVDDLEDMGRISQIRPMWDSRPSLEERLDSTTLAGSDVRGESSTSRQINGQTSHTEEKKEGEGVSRRFPEEEDEDILKESHHRFVLFPIRFRSIWQAYKACQASFWTAEELDLALDARDWEERLTENERFFILRILAFFAASDGIVGENIVSQFSMDVQIAEARAFYAYQTMIEQVHSETYSLLIETYVKDSKEKDFLFRGIDNIPCIRKKADWALKYITEELPFRVRLVAFACVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGTHTDFACLLYDHLRHRCSSEQVHDIVSEAVAIEKEFLTEALPVALIGINADLMCQYIEFVADRLVVALGYSKIYGALNPFEWMELISLQGKANFFESRVSSYQLANVSGGSGYEKSHDSSGEADHTSRRVFRLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFY5</accession>
    <name>A0A1Y1UFY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_627842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871032.1">
        <property type="nucleotide sequence ID" value="XM_022016050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFY5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFY5"/>
    <dbReference type="GeneID" id="33557859"/>
    <dbReference type="InParanoid" id="A0A1Y1UFY5"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040684">
        <property type="entry name" value="HMUDK_hel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18723">
        <property type="entry name" value="HMUDK_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="415"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="515" mass="58564" checksum="969D3AAAF3BA07F7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGD8</accession>
    <name>A0A1Y1UGD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_425118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871130.1">
        <property type="nucleotide sequence ID" value="XM_022012743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGD8"/>
    <dbReference type="GeneID" id="33554551"/>
    <dbReference type="InParanoid" id="A0A1Y1UGD8"/>
    <dbReference type="OrthoDB" id="3641682at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146638" evidence="2">
        <location>
            <begin position="17"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="257" mass="27135" checksum="A13FEDA3DBD4BAD1" modified="2017-08-30" version="1">MFSYLPLALVATLAASKPIVLPTYNASDLPHLQGVQQGSFGPKPPHLQGLEQGAFSRRSDLEARQGASGWGSNGAGGCSVSRGMATNPGDATPGNGDPHQNYWHVQLSQPISCGDGGCSVGETKTESLTVGFTVGFDTGEDSQWFTPSFSVQKSYITGNSWTCDGNPNGRVAIWQNVAHTAYSVWNTPSGNCGESNSDYDTYVNIYRAPNTDNVGGGFYCVRDDGSGYVRNQGDGYWENGCAGGPQSYCGNGQVMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGL9</accession>
    <name>A0A1Y1UGL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_426863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871157.1">
        <property type="nucleotide sequence ID" value="XM_022012753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGL9"/>
    <dbReference type="GeneID" id="33554561"/>
    <dbReference type="InParanoid" id="A0A1Y1UGL9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="168" mass="18379" checksum="A9024C71FFE1F4DC" modified="2017-08-30" version="1">MRASRLLIRANDEMCKWGSKRFDERGAEEVGSSIDDHTSNTNKRNTAFQFLCVACVHRLLPSSLTGYSCCCCCCLLDAPCVCLPGLFLVSTVFRSCGVRPFFFFFGLHATGTRPLEGWGEATAAAAAAAAAEGLYRPTSFGGGYPLREWAGLKNPSRLTCEMQLYPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGM9</accession>
    <name>A0A1Y1UGM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_624898</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871167.1">
        <property type="nucleotide sequence ID" value="XM_022015748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGM9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGM9"/>
    <dbReference type="GeneID" id="33557557"/>
    <dbReference type="InParanoid" id="A0A1Y1UGM9"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX37129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="206" mass="22490" checksum="DAF0C182B1820E37" modified="2017-08-30" version="1">MPSTLARESMYPTASTSTLPSFDFLHSLDSCVEITKECTTSLGRGLDMFKVGVEDMPRLAKVLTNRQHFLLLPHPTISSYQSTMSTTMAPHIQDLISRAERALQAQSDVLANMEQKLDILSSAEALSAIPPAAPSLSPGSTAAAPSSAYDRTSDSSDHEDGTHGRTLDSLEIKELNPAQRRAVVVLKNKRKRLEEEKKRLERGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGP2</accession>
    <name>A0A1Y1UGP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_626755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870745.1">
        <property type="nucleotide sequence ID" value="XM_022015927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGP2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGP2"/>
    <dbReference type="GeneID" id="33557736"/>
    <dbReference type="InParanoid" id="A0A1Y1UGP2"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000096">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="7"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="833"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="875"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1061" mass="115559" checksum="9AA777D59E57EBD8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGP3</accession>
    <name>A0A1Y1UGP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_625140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871236.1">
        <property type="nucleotide sequence ID" value="XM_022015773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGP3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGP3"/>
    <dbReference type="GeneID" id="33557582"/>
    <dbReference type="InParanoid" id="A0A1Y1UGP3"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="201" mass="22174" checksum="B286BF5EC15D9287" modified="2017-08-30" version="1">MESLSARCTPLKREYDSCFNAWFEGYLQPALQTGHPVYESGPSSSPSPSTSVVDNESQESHRASSVHRAGPSVPGPAGTADRKMNPLNWSSAIGAANRKVHQESRTADAYHPPQHDNDDSESRPIFVSIDPKGKTRAQVKALQYERACGQVWQQYRACLQAAIEENQGLATLLEQARNDHPLTDLESLKGTIWDEETRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGU4</accession>
    <name>A0A1Y1UGU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870793.1">
        <property type="nucleotide sequence ID" value="XM_022018292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGU4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGU4"/>
    <dbReference type="GeneID" id="33560101"/>
    <dbReference type="InParanoid" id="A0A1Y1UGU4"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="16"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="522" mass="57646" checksum="F05BF98BF4B4872C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGX6</accession>
    <name>A0A1Y1UGX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_674471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871351.1">
        <property type="nucleotide sequence ID" value="XM_022018948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGX6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGX6"/>
    <dbReference type="GeneID" id="33560757"/>
    <dbReference type="InParanoid" id="A0A1Y1UGX6"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="13">
        <location>
            <begin position="120"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="372" mass="41451" checksum="0922554979914DB7" modified="2017-08-30" version="1">MATSPAKRQLQDEDRDESEQGSSRAPTPVPKRVKREPSLARRASRGVSRAAGEPSATSDHDSESELDNSEYESELEAPTDDEEHFDDDEANVKAYEEAKAKTGDIFGWASDAGIIKQVILVDFMCHRHFSVELGNRMNFIVGHNGMLTGIAVALGGKAAVTGRGQGLKDLIRRDADKAVVTVIMSNEGPEAFKPELYGSQIVIERTLHKNGGSSYRFRATRDGKIIAQKRDELNEICANFSITIDSPLTILTQDAARSFLQNATDEMLYKFFLEGTGLDSLSAYYQKMQLQGEQLKNIADSQAEKIPLKEIEVDQLHRQVAASRRIVELQAKITRLTSELAWAYIRDKETVRTGEVNSRCFILTQHRSSRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGY2</accession>
    <name>A0A1Y1UGY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biotin-protein ligase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_625628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871336.1">
        <property type="nucleotide sequence ID" value="XM_022015814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGY2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGY2"/>
    <dbReference type="GeneID" id="33557623"/>
    <dbReference type="InParanoid" id="A0A1Y1UGY2"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28551" checksum="BFBB9C2D0D623C42" modified="2017-08-30" version="1">MGGFVSKPFSDSIRPVAAVYGGPIACDGCAESVARLLRHSNPHFKVSYLGPNEENDVTAESLKKLDLFAWPGGGDDVDDEFPQIAHYAQPIRQYVSSGGLYLGICYGAFLARGPGPDRPYFNLLPPGNWVSSERFENGSQVKGAEDAIILTDWAFHTGKKRGTVEKRRWQYFQDGGQVHLDKSVLRDTIIMGNYTYTGDPDAIIQRLDKGAIGLIGTHPEADESWYEDWDGHNPDGIRHDIGNDFVQTLWDTRMNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGY6</accession>
    <name>A0A1Y1UGY6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_580627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870446.1">
        <property type="nucleotide sequence ID" value="XM_022013449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGY6"/>
    <dbReference type="FunCoup" id="A0A1Y1UGY6">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGY6"/>
    <dbReference type="GeneID" id="33555257"/>
    <dbReference type="InParanoid" id="A0A1Y1UGY6"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="173"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="728" mass="79270" checksum="2E428AE441DABB58" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHE0</accession>
    <name>A0A1Y1UHE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_608916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871016.1">
        <property type="nucleotide sequence ID" value="XM_022014130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHE0"/>
    <dbReference type="GeneID" id="33555938"/>
    <dbReference type="InParanoid" id="A0A1Y1UHE0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="236" mass="25498" checksum="284ABB1256C520BA" modified="2017-08-30" version="1">MQSTKGLLFANNSSHFHDEDPQAEIEAVVETASEIVDKVEDTDSQGEADPGDSTLNTFSAPEGASELGKALTSNDAVESWAEGKVDIVKRRVAANTSTFEQASVPSGLEDQRRAYIARRAASSPVKTVVPTSETQSAGQDSLAEGTDFRSERPSSKCEEDDRGKGQRAGELTESSTESQKEGASGDTSPKRPELPTMTRMEIGLVKANMRTTKTKTRRMATAQMVIKMKEAKPIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHI1</accession>
    <name>A0A1Y1UHI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_608113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871507.1">
        <property type="nucleotide sequence ID" value="XM_022014102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHI1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHI1"/>
    <dbReference type="GeneID" id="33555910"/>
    <dbReference type="InParanoid" id="A0A1Y1UHI1"/>
    <dbReference type="OrthoDB" id="3243926at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="76568" checksum="24A427B71223873D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHT9</accession>
    <name>A0A1Y1UHT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_388584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871608.1">
        <property type="nucleotide sequence ID" value="XM_022012654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHT9"/>
    <dbReference type="GeneID" id="33554462"/>
    <dbReference type="InParanoid" id="A0A1Y1UHT9"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="83" mass="9834" checksum="5FB347395BB2EB7E" modified="2017-08-30" version="1">MHSLRVFICLYLPPRMTACFSPSELFRTRVEQQAFRRTHTEIRLGLRRFLARKSTDQVLGNYRSLLQVRHERSLVGEVRECLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHW8</accession>
    <name>A0A1Y1UHW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_650701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871124.1">
        <property type="nucleotide sequence ID" value="XM_022018192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHW8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHW8"/>
    <dbReference type="GeneID" id="33560001"/>
    <dbReference type="InParanoid" id="A0A1Y1UHW8"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013276870" description="FAD-binding domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="436" mass="47598" checksum="C4FAD593E62F098F" modified="2017-08-30" version="1">MAGLRVLIVGASIAGPATAYWLSKAGARITIIERFPSLREGGQAIDIRVCGVSVMRKMHGMEERVRAQSTQEEGVSFIRPDGRPYGVIRMTGNPDRQSLISEYEIYRGDLSKILVDLPEQKSSIDYIFGEEVASIRYEGDKAPVTVEFKNGTARSEFDLVIGCDGSFSRTRAMALGCGVRDHVIPTRSWAAYYSIPKDLCNGSKIGVGISAVGGRTISIGSDRFTESTRVALFANPPSSPSSSSSSAQDPMRAFREALSEGQDHVKLHIANRFRGMGWITDELLQGMMDSKDFYASEIVQVKAPSIFDRRVVLVGDAGYAAGPTGGGTSLALTGAYVLAGSLFKYPGDIDAALAEYEQVMRPIITELQKIPPFVNTIMAPQTAWGIWLRNHLFALIAWTGVAEFLGTYFAAGFSDSKKFPLPDYDWDRKDTIPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI72</accession>
    <name>A0A1Y1UI72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4 transglutaminase-like domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_579270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871222.1">
        <property type="nucleotide sequence ID" value="XM_022013370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI72"/>
    <dbReference type="FunCoup" id="A0A1Y1UI72">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI72"/>
    <dbReference type="GeneID" id="33555178"/>
    <dbReference type="InParanoid" id="A0A1Y1UI72"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="481"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="533"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="603"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="82764" checksum="17C6DB93649D84DC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIJ9</accession>
    <name>A0A1Y1UIJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_650394</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871838.1">
        <property type="nucleotide sequence ID" value="XM_022018139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIJ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIJ9"/>
    <dbReference type="GeneID" id="33559948"/>
    <dbReference type="InParanoid" id="A0A1Y1UIJ9"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF390">
        <property type="entry name" value="PROTEIN KINASE C, BRAIN ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="122"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="803"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1149" mass="125152" checksum="98FD141915F6950F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIK5</accession>
    <name>A0A1Y1UIK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_680710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871819.1">
        <property type="nucleotide sequence ID" value="XM_022019092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIK5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIK5"/>
    <dbReference type="GeneID" id="33560901"/>
    <dbReference type="InParanoid" id="A0A1Y1UIK5"/>
    <dbReference type="OrthoDB" id="2592178at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="75593" checksum="D06C08FB956DED9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIP7</accession>
    <name>A0A1Y1UIP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_623606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871859.1">
        <property type="nucleotide sequence ID" value="XM_022015607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIP7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIP7"/>
    <dbReference type="GeneID" id="33557416"/>
    <dbReference type="InParanoid" id="A0A1Y1UIP7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="474" mass="51531" checksum="2F3162A1B749DB2A" modified="2017-08-30" version="1">MPNTSIQTTISPYTQKPLLTRPLLSEQELENVIGESVKAQKAWRKVSLDDRLDIADKWTTEFEKLTDLMAEDISSQMGRPISSCKGEISGTLYRARHLMKIAKDCLKPVPQDKPGSGNFDMSIVREPLGVVAAITPWNFPFLTMINSVLPSILSGNSVIIKPAPQTPVPAERLLSTFISAGLPQNVIQVIHLSQEMTLQKFVTDPRIDFVCFTGSVVGGRAVQEAASRGQGFKGIGLELGGKDPAYVREDADVAYTAENLVDGAMFNSGQSCCAVERIYVHSSIYDEFVKKFVEVAKQYKLGDPSLPETTLGPVVSPASASRIRKQVNDAVAAGAELVLAESEFAEAKEGTSMVGPQVLVNVTHEMEIMMEETFGPVVGIMKVESDEEALGLMNDSPYGLTASIWTSPSNPESINAFNHFVEDLECGMVYLNRADAPEPALPWTGVKNSGRGITLSTLGYDQLTRAKGVCRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIT0</accession>
    <name>A0A1Y1UIT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_448018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871442.1">
        <property type="nucleotide sequence ID" value="XM_022012806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIT0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIT0"/>
    <dbReference type="GeneID" id="33554614"/>
    <dbReference type="InParanoid" id="A0A1Y1UIT0"/>
    <dbReference type="OrthoDB" id="2596974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="599" mass="64462" checksum="BADD0C3ED6527782" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIW1</accession>
    <name>A0A1Y1UIW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871909.1">
        <property type="nucleotide sequence ID" value="XM_022015630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIW1"/>
    <dbReference type="FunCoup" id="A0A1Y1UIW1">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIW1"/>
    <dbReference type="GeneID" id="33557439"/>
    <dbReference type="InParanoid" id="A0A1Y1UIW1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="328" mass="36086" checksum="FE6B1586651DB19A" modified="2017-08-30" version="1">MTTLAFQNIHVPSPGYGAMSLSHAYGPADDDESIRVLKTALDSGCTFWDTAVVYGMGHNESLIGRFLKENPDAREKLFIASKCGWDLDFEKKENHGVTNKVAHIQEYIQGTIKRLGTTPDLYYLHRMKPEETPLSESIAALDGLKKAGKCKYIGLSEPSARTLRKACEVAHIDAIQIEYSPWFIDHERDGLIDAARELGVSIVAYSPLGKGLLTGKHRDASAFSKDIRGTAPRYTGENFDKNLALVDEFERLAKSKGCTPGQLSLAWVAAQGAIPIPGTKNADRVKENWGANKVTLTEGELKEIRKVIQENEPVGDRYAEGHMALVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ43</accession>
    <name>A0A1Y1UJ43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_412943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871976.1">
        <property type="nucleotide sequence ID" value="XM_022012715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ43"/>
    <dbReference type="GeneID" id="33554523"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ43"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="273" mass="29237" checksum="15B1791BF0885D47" modified="2017-08-30" version="1">MNGIKCSVSCPVLGVFLATHSFSRITERYQLRATQPRNTYRQPNTHHIISHRKNTGAMSEGSSDEEAQRFVANYPLGSSPGLGPVTNESSVGASPATSEVGERASEASETSDVPVTRSTVQITEPEQGYTSSASSNQASHQGDEEALLSRSRRGQDENVLSPLAAHGCASQAVSQGDDSETDGSYASGVDNRFSVVREGRTQVAKPSPSSENPGSDSESGHEHFEDAHEQLVSRPEYGKRRGSSVSLLTNSTSRLLKARRPSERSLLTDSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJE2</accession>
    <name>A0A1Y1UJE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_588413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872093.1">
        <property type="nucleotide sequence ID" value="XM_022013764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJE2"/>
    <dbReference type="GeneID" id="33555572"/>
    <dbReference type="InParanoid" id="A0A1Y1UJE2"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="911" mass="103804" checksum="61C36BC72B4C15B6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJK6</accession>
    <name>A0A1Y1UJK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">YetF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_620100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0702 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872155.1">
        <property type="nucleotide sequence ID" value="XM_022015244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJK6"/>
    <dbReference type="GeneID" id="33557052"/>
    <dbReference type="InParanoid" id="A0A1Y1UJK6"/>
    <dbReference type="OrthoDB" id="3826282at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="entry name" value="bsu07140 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34582">
        <property type="entry name" value="UPF0702 TRANSMEMBRANE PROTEIN YCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34582:SF6">
        <property type="entry name" value="UPF0702 TRANSMEMBRANE PROTEIN YCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="YetF C-terminal" evidence="9">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="239" mass="26036" checksum="11516161D3EE7A95" modified="2017-08-30" version="1">MSNLTYQDCGNGVTASQNPAGFDAIQVSDFFSIASLLHPITVGAIAIVTLFLYLRLSSNRCVAPVTLFDWIINVALGSTLAGIVNGTSLLRGLISLVTLLLFQLILSYMSSNYGSILEHAINAPPLVIAFRGRALDKVMAHHRVSKSDLNGALRRFGIWNISQIEAVIIEPTGEFTIYKQNDCPEGVNPEVLMDVPGYRRLVEHFDKEGIAGCSTSKKDKQLNKKKDGQIANDLASREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJS3</accession>
    <name>A0A1Y1UJS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallopeptidase family M24-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_622979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871703.1">
        <property type="nucleotide sequence ID" value="XM_022015536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJS3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJS3"/>
    <dbReference type="GeneID" id="33557345"/>
    <dbReference type="InParanoid" id="A0A1Y1UJS3"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="540" mass="59384" checksum="A27160EFA2CB7538" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK84</accession>
    <name>A0A1Y1UK84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CRM1 C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_353671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872314.1">
        <property type="nucleotide sequence ID" value="XM_022012562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK84"/>
    <dbReference type="FunCoup" id="A0A1Y1UK84">
        <property type="interactions" value="1014"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK84"/>
    <dbReference type="GeneID" id="33554370"/>
    <dbReference type="InParanoid" id="A0A1Y1UK84"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1076" mass="122221" checksum="DF420F07499CF766" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKT4</accession>
    <name>A0A1Y1UKT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="11" type="ORF">BD324DRAFT_621467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKT4"/>
    <dbReference type="FunCoup" id="A0A1Y1UKT4">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKT4"/>
    <dbReference type="InParanoid" id="A0A1Y1UKT4"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="125"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="602" mass="64675" checksum="F67E9546F71899D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKX2</accession>
    <name>A0A1Y1UKX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_578043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872625.1">
        <property type="nucleotide sequence ID" value="XM_022013296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKX2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKX2"/>
    <dbReference type="GeneID" id="33555104"/>
    <dbReference type="InParanoid" id="A0A1Y1UKX2"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="810"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1071" mass="116517" checksum="D8FD74CA8200996E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL98</accession>
    <name>A0A1Y1UL98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_641199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872686.1">
        <property type="nucleotide sequence ID" value="XM_022017405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL98"/>
    <dbReference type="FunCoup" id="A0A1Y1UL98">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL98"/>
    <dbReference type="GeneID" id="33559214"/>
    <dbReference type="InParanoid" id="A0A1Y1UL98"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="556"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="633" mass="68418" checksum="D0BA371A2EA6C605" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULM9</accession>
    <name>A0A1Y1ULM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_648994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872752.1">
        <property type="nucleotide sequence ID" value="XM_022017916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULM9"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULM9"/>
    <dbReference type="GeneID" id="33559725"/>
    <dbReference type="InParanoid" id="A0A1Y1ULM9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="549" mass="58676" checksum="AD10DCBF3301F149" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM43</accession>
    <name>A0A1Y1UM43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_621526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872519.1">
        <property type="nucleotide sequence ID" value="XM_022015390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM43"/>
    <dbReference type="GeneID" id="33557199"/>
    <dbReference type="InParanoid" id="A0A1Y1UM43"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="67" mass="6997" checksum="E2961E000BE2BB0A" modified="2017-08-30" version="1">MASKPFQNSPPDAQLQTPVDKGSGPEPETPTQQRKAGGLALSQGMSSALDVTQTPQQGEGRWYGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMF3</accession>
    <name>A0A1Y1UMF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase DBP2-A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_618931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873096.1">
        <property type="nucleotide sequence ID" value="XM_022015099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMF3"/>
    <dbReference type="FunCoup" id="A0A1Y1UMF3">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMF3"/>
    <dbReference type="GeneID" id="33556907"/>
    <dbReference type="InParanoid" id="A0A1Y1UMF3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="146"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="349"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX39233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="544" mass="57470" checksum="BA98FA514423905A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN00</accession>
    <name>A0A1Y1UN00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_619686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873293.1">
        <property type="nucleotide sequence ID" value="XM_022015197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN00"/>
    <dbReference type="GeneID" id="33557005"/>
    <dbReference type="InParanoid" id="A0A1Y1UN00"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="435" mass="47353" checksum="CA3B7F0EDEE5C119" modified="2017-08-30" version="1">MVRTRSQGSTPTLTVYGATSFTARELLRYLDHHPDGESFNLILSGRNEEKLKAATKDMKRDKELVACELTDEESVRDLVDRSTVIINLAGPFREHHAEALIRACAATGTHYLDLCGERYFLGKVIIPKYDYQASTTGSCIVIASGFDSIPSDMSLYLALRTLQSSYPDASIASSRAFFKTGGSPSGGTMASAKSEAETPAEEKIVKKGEWMLTSASGPTPPPQLVYESSHPSLPRSLTGGFFFMYPFNCCVVRRSWFLSRLSEDATGIKRGDEPRHGDKLEYTEALQTRSWIESIIVSLGLMLFGLVFFGSTLTRNILLWLLPSPGSGPSDKSLRSGGLELTSISKTTAQGVTVVTTCKHKGDPGYIATNYMIVEAALSLILPPPSDTKLPPLASKGGVLTPSTALGMVLIERLNQSGKVIWDCKLHDDSKGHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNC3</accession>
    <name>A0A1Y1UNC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872547.1">
        <property type="nucleotide sequence ID" value="XM_022018071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNC3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNC3"/>
    <dbReference type="GeneID" id="33559880"/>
    <dbReference type="InParanoid" id="A0A1Y1UNC3"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="122452" checksum="C1F11E84806FB1E7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNG7</accession>
    <name>A0A1Y1UNG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_586576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 12"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873386.1">
        <property type="nucleotide sequence ID" value="XM_022013745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNG7"/>
    <dbReference type="FunCoup" id="A0A1Y1UNG7">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNG7"/>
    <dbReference type="GeneID" id="33555553"/>
    <dbReference type="InParanoid" id="A0A1Y1UNG7"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX39601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="379" mass="42793" checksum="07A8A1B33883D627" modified="2017-08-30" version="1">MSFAVPKLKLAETWKELEFPELQNDLLLRAANGEETPEAPVWMMRQAGRALPEFRALREKHEFFKCCQTPELACEITLQPIERFKRISGSILFCDILVIPQALGMEVKMLPEKGPSFPEPLLDPSHLSRLNNKVNIDDTLGYVFDAITMIRKKLDGRVPLIGFCGAPWTLMAYMIEGGGSKTFEKAKQWLYRYPEESNKLLMMIADACADFLVGQVLAGAQMLQVFDTWAGELTPHHFESFELPALLHISRKVHFCLKAISHPDVKITLFAKGVHAPQSLRLISDPDVTGYATLSLDWQVDPVEVREIVGKKVNFQGNFDPVILYAGREGIEKEVERVCKLFHKAGGGWIANLGHGVTPNVKPDDMGWFLECIHKYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNH3</accession>
    <name>A0A1Y1UNH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_679539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872897.1">
        <property type="nucleotide sequence ID" value="XM_022019044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNH3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNH3"/>
    <dbReference type="GeneID" id="33560853"/>
    <dbReference type="InParanoid" id="A0A1Y1UNH3"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="185"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="361" mass="40666" checksum="BFE8BEB82420EA9B" modified="2017-08-30" version="1">MSIPTTEAEIAAVFAPSAKFSLGCMFAQVCVDSFFCGVLTMQGKSFIPSIYSYFKYQRRDSWWIKSVVITTAIINLVVTIYLWYFISYLFVQNFGLWSPFAETKYLAWFPFLDSLNSAVVQAFFAYRAYRLCNRMWIIPLVCGVLILTSVGATLAVLILFSSFASLFQADGVTVPELIWLSSIMSADIIITISILFGLWRSKTGWSHTDRVITRLIRMTLESQVPPTIIAITFMVEFVQTPSSLFGSTLQGIQPKLYAVGLMYALNARITFQQQWVGDKDRTGGQVFAMSNRPTQKTQLQVDVETETYVQSTPAYTLDERPGLNRGPYDTMEDKKSAEDLQDLHVNAEPGVYGSRARLTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNH9</accession>
    <name>A0A1Y1UNH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_614189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873354.1">
        <property type="nucleotide sequence ID" value="XM_022014571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNH9"/>
    <dbReference type="GeneID" id="33556379"/>
    <dbReference type="InParanoid" id="A0A1Y1UNH9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="81" mass="8896" checksum="0B82AD0D7FA12304" modified="2017-08-30" version="1">MELNLRMAELEQAKLFAIEDMEYGGAAGTADQTPLQDAVNHANEQVARLRNEARKRQEGTVPLCVRISGSQQPTPTTMSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP55</accession>
    <name>A0A1Y1UP55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_648438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873598.1">
        <property type="nucleotide sequence ID" value="XM_022017840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP55"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP55"/>
    <dbReference type="GeneID" id="33559649"/>
    <dbReference type="InParanoid" id="A0A1Y1UP55"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="276" mass="31191" checksum="48E9BE4583A8BF2A" modified="2017-08-30" version="1">MPLPRTLPGTEAQEGVEYEEDWLPKDFKPMTVGQLMWYKMKNMPMVNVGLAGVIGSFGMASYWFRMGNSARLNYWLRWRVGMQIFTFGWIIYYGGMAFTAERQTQTYYKQMVMLGDLPPDTKIPKASNDLFAKKDDWRKAIMNPSAFEKPKQTAATSSAPDVPQTDVDQYPKAVSERMTTADFKSKIQQRQQAAAPSANDSDAFAARLEGAIRAQAEEDEMRGKGKLKGAQSVTGRGELLRRRGREMAAQKEEKAARDNAAREAENETEVEDSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPC9</accession>
    <name>A0A1Y1UPC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_615183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873617.1">
        <property type="nucleotide sequence ID" value="XM_022014689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPC9"/>
    <dbReference type="GeneID" id="33556497"/>
    <dbReference type="InParanoid" id="A0A1Y1UPC9"/>
    <dbReference type="OrthoDB" id="3938502at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029483">
        <property type="entry name" value="GH97_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019563">
        <property type="entry name" value="GH97_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029486">
        <property type="entry name" value="GH97_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052720">
        <property type="entry name" value="Glycosyl_hydrolase_97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35803">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE SUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35803:SF2">
        <property type="entry name" value="RETAINING ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14509">
        <property type="entry name" value="GH97_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14508">
        <property type="entry name" value="GH97_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10566">
        <property type="entry name" value="Glyco_hydro_97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase 97 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase 97 catalytic" evidence="5">
        <location>
            <begin position="273"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase 97 C-terminal oligomerisation" evidence="7">
        <location>
            <begin position="492"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="593" mass="66685" checksum="82B92621ECAA090A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPN5</accession>
    <name>A0A1Y1UPN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_615975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873805.1">
        <property type="nucleotide sequence ID" value="XM_022014775.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPN5"/>
    <dbReference type="GeneID" id="33556583"/>
    <dbReference type="InParanoid" id="A0A1Y1UPN5"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="627"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="1183"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1136"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1322" mass="145173" checksum="0F03FC81EB23A34E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPY9</accession>
    <name>A0A1Y1UPY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_255149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873854.1">
        <property type="nucleotide sequence ID" value="XM_022012296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPY9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPY9"/>
    <dbReference type="GeneID" id="33554104"/>
    <dbReference type="InParanoid" id="A0A1Y1UPY9"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000270">
        <property type="entry name" value="Nuclear envelope-endoplasmic reticulum network protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="270"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="469" mass="51626" checksum="D981EE9D0515536C" modified="2017-08-30" version="1">MNTLSRLDNHLSSYFISTPPPRSPSRRSSSHSPSSPSLTRSSSSRHHSASGARSPSGPRGRRRGRRPKPTTSNVKVPPPSTPVLLRILLALWSILLSFWQSLVGEIRAERLQRKRAARLLQHLTGAAAAPAEQKERDDGSGSDSEAASSEDEPWIDPVTRAPETTLHENDSSSALFAGDNSSEPFTFRLPSAEKKEGESSTSNPSNGQLTSILDNPILSSPGSRSKQARLLPNPMSTSLLDPSVPVVPASQTIMTRGSLSKYPPRPHQTPFHLQKTLILDLDETLIHSTARPLSYAASAGGGLLGLSFGGLFGKGRRREGHTVEVVLRGRSTTYHVYKRPYVDHFLKKVASWYTLVIFTASMPEYADPVIDWLDGGRGLFAKRLYREDCCLTQPGSYVKDLSLVEPDLSRVCFMDNSPISYMWNKANALPVEGWTSDPNDEALLHCIPVLDSLRFVNDVRRVLGIRGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ16</accession>
    <name>A0A1Y1UQ16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_254115</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873847.1">
        <property type="nucleotide sequence ID" value="XM_022012294.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UQ16">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ16"/>
    <dbReference type="GeneID" id="33554102"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ16"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15725">
        <property type="entry name" value="FYVE_PIKfyve_Fab1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
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            <begin position="327"/>
            <end position="387"/>
        </location>
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            <begin position="1911"/>
            <end position="2239"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="109"/>
            <end position="243"/>
        </location>
    </feature>
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            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <end position="1457"/>
        </location>
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            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1818"/>
            <end position="1838"/>
        </location>
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            <begin position="1"/>
            <end position="11"/>
        </location>
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            <begin position="172"/>
            <end position="184"/>
        </location>
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            <begin position="185"/>
            <end position="194"/>
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            <end position="1673"/>
        </location>
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        <location>
            <begin position="1674"/>
            <end position="1684"/>
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            <begin position="1723"/>
            <end position="1736"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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            <end position="1776"/>
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        <location>
            <begin position="1777"/>
            <end position="1790"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075294"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX40062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2262" mass="250972" checksum="6B35438CC8537F4A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ50</accession>
    <name>A0A1Y1UQ50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA splicing factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_607229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="21123at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
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        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="164"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQB2</accession>
    <name>A0A1Y1UQB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_641123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873974.1">
        <property type="nucleotide sequence ID" value="XM_022017397.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQB2"/>
    <dbReference type="GeneID" id="33559206"/>
    <dbReference type="InParanoid" id="A0A1Y1UQB2"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="62"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="6">
        <location>
            <begin position="934"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1456" mass="160937" checksum="A3354ED9A214E86D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQE8</accession>
    <name>A0A1Y1UQE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_614566</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873461.1">
        <property type="nucleotide sequence ID" value="XM_022014615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQE8"/>
    <dbReference type="FunCoup" id="A0A1Y1UQE8">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQE8"/>
    <dbReference type="GeneID" id="33556423"/>
    <dbReference type="InParanoid" id="A0A1Y1UQE8"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="177" mass="19114" checksum="E540FDCFA5109710" modified="2017-08-30" version="1">MSLLRQTPATLRTGLGSRSLHTSRVLSIRVSAPRRDATVSANETGGFKYVAGGPVLKGTVNDANTFPEPSKTHGSYHWAFERTLSAALIPILGGAVVTSGTAHPILDAVLALSLVVHSHIGFDASITDYFHPRKWPVVGPIMTWLLRLATGGVVWGLYEFNTNDIGLTELVRRLWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQJ2</accession>
    <name>A0A1Y1UQJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_614704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873501.1">
        <property type="nucleotide sequence ID" value="XM_022014633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQJ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UQJ2">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQJ2"/>
    <dbReference type="GeneID" id="33556441"/>
    <dbReference type="InParanoid" id="A0A1Y1UQJ2"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000205">
        <property type="entry name" value="2'-5'-oligoadenylate synthase-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="1">
        <location>
            <begin position="386"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="43661" checksum="2527626404166A9A" modified="2017-08-30" version="1">MAEASSSSDVIKITVKGPSELKLSIEIDPSKTVAELKEVIAEKSDVEKDRQRLIYSGKVLKDEEQISTYKIQNGHTLHMVKGANKTQAAAAGGVTASPAAGGSTSQSQQLPRMGTGLNVAGNPVDNIENIPHGLGGFNPFANMAGLNNLNDPNAMTSMMQNPDFLREMSNMMSRPEVLDQMINSNPQLAQMGPQIRAAMQSPMVQQILRDPEALRSMMAMQAQMGGGNPMGGGGGAFGNPFGGGLGGNPFAALGGGAGARAGTEGSNTAEDPFPNLFAAGQAAQTGAGGTGAGARGGGAGAGAGGNPFGAVNYEALTRAMMGGAGAGVGAGAGAGAGTGAAAGTEGNAMGQANPFAMYQNMFGGMGAGGWGGMGGFGSPPPPADTRPPEEIYATQLGQLNGMGLWDAQKNIRALRATGGNVEAAIELIFSGSLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQL7</accession>
    <name>A0A1Y1UQL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_586782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873521.1">
        <property type="nucleotide sequence ID" value="XM_022013748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQL7"/>
    <dbReference type="FunCoup" id="A0A1Y1UQL7">
        <property type="interactions" value="737"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQL7"/>
    <dbReference type="GeneID" id="33555556"/>
    <dbReference type="InParanoid" id="A0A1Y1UQL7"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="506"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="663" mass="73628" checksum="3190D9687038A2D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR57</accession>
    <name>A0A1Y1UR57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_640517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874230.1">
        <property type="nucleotide sequence ID" value="XM_022017352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR57"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR57"/>
    <dbReference type="GeneID" id="33559161"/>
    <dbReference type="InParanoid" id="A0A1Y1UR57"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="374" mass="40236" checksum="C1A101897376B5E8" modified="2017-08-30" version="1">MNGYYPDWSAWYLAPEDVDFTKFDVIDFAFALPTADNGLQFTQDTSSDSLRRLVTTAHAAGKKVKLSIGGWTGSQYFSTIVSQSWSTTAFVNNILEAYHEYDLDGIDIDWEYPGVQGAPGNAVSPNDAANFLNFLQILRATLPSDALISLATQVWPFAGPDGNPLSDVSGFADVIDWILIMNYDIWGSSSTPGANAPLSNGCGNSSQPLANAYSAVASWEAAGMPANKITLGVPAYGYLQMSWATRLQDRSLPHKEYAARDYLTIQNDNGGTADGQVMFESLISQGALVLDSAGDYVGGGGFFRVWDECSSTPFLKSWDSGQIVTYDDPQSVSLKGQFAAQAGIKGCNIFSIDGDWTGSSWPLTDAVRSGMGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR83</accession>
    <name>A0A1Y1UR83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_647476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874229.1">
        <property type="nucleotide sequence ID" value="XM_022017666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR83"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR83"/>
    <dbReference type="GeneID" id="33559475"/>
    <dbReference type="InParanoid" id="A0A1Y1UR83"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="420" mass="46832" checksum="DBAC1798C0810C9A" modified="2017-08-30" version="1">MSSPLASHPPSTPPPRSQPFTAPKFISHNSPSVHSSQHRRPSDASFSASMMDVDPGGDGEESINDVDQDIDELLSSSDERPPASPSGSGTGSRAGGTAGGGAARRTSGNDNASTGRGGPKKMRARATKKKVEDLPEFSCRWDDCEVIPDDQESLINHLHEVHAPEGLEEYRCQWFNCPRKGHKQSNRTGLITHVRIHTGEKPYKCPQEGCDRAFTRNDAMNKHLRTFHAEKHEELKELKNKEKKATTTTTMTTTTTTAMTNSNSSRSQARRTGASGSTTGGLKSSDKILMDDADLIDVLPRLRNRKRFWTITEDDEKVLAAIRSRYPRPPSDSREYDEEFDLGRSRDFPERCPEDIQSQAHEPPSDSQVIFMGRSQWQVRYIIAKAKLMLVEEENAMRKAQLMELMEQEAQLLAQQQSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URR6</accession>
    <name>A0A1Y1URR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873620.1">
        <property type="nucleotide sequence ID" value="XM_022014690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URR6"/>
    <dbReference type="STRING" id="4999.A0A1Y1URR6"/>
    <dbReference type="GeneID" id="33556498"/>
    <dbReference type="InParanoid" id="A0A1Y1URR6"/>
    <dbReference type="OrthoDB" id="5550090at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="659" mass="70263" checksum="BCB5A420100CC2F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URX0</accession>
    <name>A0A1Y1URX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_21337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874470.1">
        <property type="nucleotide sequence ID" value="XM_022012193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URX0"/>
    <dbReference type="STRING" id="4999.A0A1Y1URX0"/>
    <dbReference type="GeneID" id="33554001"/>
    <dbReference type="InParanoid" id="A0A1Y1URX0"/>
    <dbReference type="OrthoDB" id="3259825at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="146" mass="15753" checksum="99086EAC6DCC19C9" modified="2017-08-30" version="1">MIRSASAETGGSRMSEARSDRASGRQSSGGGSFYDYYNEGEETLVSPQEGSSRRAKTASQAVEITEYADGKLVWSLVDGLRDVDEVDGPEPFGLHSRNTSVDSAYPSEKEDLGDAEALDTQGIAGLNLRHRDRAQPLDRPPTNVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USD3</accession>
    <name>A0A1Y1USD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP12-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_612582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874610.1">
        <property type="nucleotide sequence ID" value="XM_022014408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USD3"/>
    <dbReference type="FunCoup" id="A0A1Y1USD3">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USD3"/>
    <dbReference type="GeneID" id="33556216"/>
    <dbReference type="InParanoid" id="A0A1Y1USD3"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33055" checksum="3E3A5202456F0B06" modified="2017-08-30" version="1">MKSLRLARLVRATRPQPAPICQSCPSRLLLRSYISTRPRFAEVQSGPIISQSNRAEITLRRFWKSAHVAEEADGTFRIKLDHRDLKAPSGKILVLPKGKRLFATLIAAEWDNQAEAMKPTSLALTSLAFRAIDGFNDPASRCKVVDKLMQYLETDTILYHDDGTGAPTLESMQRHHWDPLLQWVTESFGIELSLATGFSPAKQSPPVLERLRQEIDKMDHWQLAAFERATYASKSFIIGLALCSGRLTADQASDASHVEVRSQIERWGEVEDSHDVDYQDIRKMLGSVAISLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USS4</accession>
    <name>A0A1Y1USS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Methylcrotonoyl-coenzyme A carboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_640710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874681.1">
        <property type="nucleotide sequence ID" value="XM_022017364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USS4"/>
    <dbReference type="STRING" id="4999.A0A1Y1USS4"/>
    <dbReference type="GeneID" id="33559173"/>
    <dbReference type="InParanoid" id="A0A1Y1USS4"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="85"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="204"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="658"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX41002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="743" mass="80640" checksum="5D2ADD0129756AE2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTD3</accession>
    <name>A0A1Y1UTD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="12">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_612102</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874463.1">
        <property type="nucleotide sequence ID" value="XM_022014351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTD3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTD3"/>
    <dbReference type="GeneID" id="33556159"/>
    <dbReference type="InParanoid" id="A0A1Y1UTD3"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="95"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX40784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="354" mass="38364" checksum="84DC117AD56AE89D" modified="2017-08-30" version="1">MPMFARAAPSLRAGLTSCHQLRAGCRSYADASGQSSGGAKILGLPIWLLAAVGVAGAVELSGNGVFLKAKSKEAVEAVKQAAAPAAPREAVLIKDQWIPFTLSKVEPYNHNSKVYHFEFPPEGKDKTTGIPVAGALLTKAPDEAGINDDKGKPVIRPYTPISSPDETGSVKLLIKEYKGGKLTPFISTLKPGEGQLMFKGPIEKYKYQPNTFDRGLCIAGGSGITPMYQLINHSLSIPDDKTKWTLIFSNVTEADILLRKEWENLAKQHKDRLDIKFVLDKAPRGWQGPTGFINAQMISQLFPYHDGQNKVMAFVCGPPPQVKSISGPKDGPRQGEVQGALKDLGYTSDEVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE3</accession>
    <name>A0A1Y1UTE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L18e/L15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_611812</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874375.1">
        <property type="nucleotide sequence ID" value="XM_022014310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTE3"/>
    <dbReference type="FunCoup" id="A0A1Y1UTE3">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTE3"/>
    <dbReference type="GeneID" id="33556118"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE3"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="310" mass="34365" checksum="236F81B577784384" modified="2017-08-30" version="1">MRFNPFSSIASFSTALRASTSRVRLPARPSTRLFLPALPPAFVRGNHDVSLSSLKPSPGSTKNRRRVGRGVGSKMGGHTTGRGHKGQKSRSTIPYIGFEGGQTPLYQRIPKRGFSNPFRKTYASLSIAKIQKWIHQGRIDPTQPITIRTVIKSNVVHGIGTHAGVKLLGTVDESLPLPSLNISMSKFTMAAGRAIIKAGGTCTAVYHNRLSLMQELRPHKFIGREITPAKPVRRKDIEYYTDATKFGYLANERDKLFLDRGFDPHMKRSKVAGRPYKDTRGLTPEEAAAKDAELAKEKMANIMNIQMMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU15</accession>
    <name>A0A1Y1UU15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_678329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874595.1">
        <property type="nucleotide sequence ID" value="XM_022018986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU15"/>
    <dbReference type="FunCoup" id="A0A1Y1UU15">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UU15"/>
    <dbReference type="GeneID" id="33560795"/>
    <dbReference type="InParanoid" id="A0A1Y1UU15"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="795" mass="87127" checksum="511D5BB3E8C26CAA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU57</accession>
    <name>A0A1Y1UU57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874394.1">
        <property type="nucleotide sequence ID" value="XM_022014318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU57"/>
    <dbReference type="FunCoup" id="A0A1Y1UU57">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UU57"/>
    <dbReference type="GeneID" id="33556126"/>
    <dbReference type="InParanoid" id="A0A1Y1UU57"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF2">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012237359" description="Protein ROT1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="247" mass="26472" checksum="E8804266FE553462" modified="2017-08-30" version="1">MISLILASFALLSPLASAQGPDLSSANNVTSLEGEWSSNAAVGTGGDFCIPAEMKFTYPNNTGIAYAFTDDGFFEEAMYRYKGNASNPKCITATIQWQHGRYGLNDNGSMTLYPFGADGRIQVQDPCAAVTNIITYIDQQTLYADWGITIDQQTKNYVLKLNRFDGAKMPPMYLTARPPNMLPTQPLTGVNASGQQVTTRKRSTVTISDFLKRGSAPSRLSLGSDNAVMGAAGVAVGLMASISVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUD3</accession>
    <name>A0A1Y1UUD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_46918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874853.1">
        <property type="nucleotide sequence ID" value="XM_022012873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUD3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUD3"/>
    <dbReference type="GeneID" id="33554681"/>
    <dbReference type="InParanoid" id="A0A1Y1UUD3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1050" mass="111874" checksum="EDDA0A30BA01B38D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5K0</accession>
    <name>A0A1Y1U5K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_654252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000027">
        <property type="protein sequence ID" value="ORX33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867654.1">
        <property type="nucleotide sequence ID" value="XM_022018776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5K0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5K0"/>
    <dbReference type="GeneID" id="33560585"/>
    <dbReference type="InParanoid" id="A0A1Y1U5K0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12092" checksum="CC6B6C950B0CCD3A" modified="2017-08-30" version="1">MTHGPDDDVKNATARYVFICFGGAGIWSAIPIFLSWMVTMFDGREKRAISIALINGFGNIASVYGSFLWPAWVKPLYHVGFGVTTGMLGVAAWMTLALKWRYGDIGVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U681</accession>
    <name>A0A1Y1U681_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_277955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867860.1">
        <property type="nucleotide sequence ID" value="XM_022012361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U681"/>
    <dbReference type="GeneID" id="33554169"/>
    <dbReference type="InParanoid" id="A0A1Y1U681"/>
    <dbReference type="OrthoDB" id="74813at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="27907" checksum="5AEA54EDC1A89D16" modified="2017-08-30" version="1">MATKTIHSVPDASLVQSVPSTSMVLSSRAPDALNAPSSGSTKLPNANRNKKRGFFKEMESLRGVRTTFDDDQGGSSSFVGTRDSAPSEPIQTHEAFIPDGTILAPKSTPSSSSRRYIRPPSEMVDLPSNVIVTSVEYSAQRSPASLTPNGKYRGAAFGHSAIPTSVQPSPAPEAATAAPCAQAATDDASRASTSHGHTSPSRTSHTDFTPDEFSAIWEQIEWHAFDKLESIVARSTYDDLRGQYLARMVSLLREVPGSDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6I1</accession>
    <name>A0A1Y1U6I1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="7">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_584711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867950.1">
        <property type="nucleotide sequence ID" value="XM_022013701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6I1"/>
    <dbReference type="FunCoup" id="A0A1Y1U6I1">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6I1"/>
    <dbReference type="GeneID" id="33555509"/>
    <dbReference type="InParanoid" id="A0A1Y1U6I1"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000094">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="625" mass="69129" checksum="E56AA55A7716BF8D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6U9</accession>
    <name>A0A1Y1U6U9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein 12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_638341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868021.1">
        <property type="nucleotide sequence ID" value="XM_022017104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6U9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6U9"/>
    <dbReference type="GeneID" id="33558913"/>
    <dbReference type="InParanoid" id="A0A1Y1U6U9"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="282" mass="31898" checksum="6119A951C871BD51" modified="2017-08-30" version="1">MSSSSRPKSNIELLTEQHKYVQKARKARAEQIESIKFDDDARREWLSGFSKRKKAKVEEKRARAIERDKQAHKEERRHAREELKKKAAENVRNVRLAMGLPTGDDEEMASGDESSNEGPAVPLEDEYEDDDQIATVTITEDFDPSIPGPSTRKFGSPSSDEEGDEHRSGQLGDAEKTKKRKAVGLPDMPASSHRAQKKAKSILEQAKLEKKERQERAEKADKQSRGMETKAERKFGRAMEAKRRAKRAGIAMERDGRQRGTDKGKRKGNGAHNKPLRGRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U768</accession>
    <name>A0A1Y1U768_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_638919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868170.1">
        <property type="nucleotide sequence ID" value="XM_022017172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U768"/>
    <dbReference type="STRING" id="4999.A0A1Y1U768"/>
    <dbReference type="GeneID" id="33558981"/>
    <dbReference type="InParanoid" id="A0A1Y1U768"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="173"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="333" mass="37032" checksum="93EAE3253187F49F" modified="2017-08-30" version="1">MATRIGLGGLQSLSRCAESVFYRSNASTSRPLRHFFSPSHVQRQPLTLLHSSFTGPRRTASKLLEGLYSRPSASQESLRASLRRGILLFKRAPRTEQRWRSWQGSGGGGGGFGGRSGLLRDPNFIVPILIGVNIAICGLWQYAQFSYNRFHDASLLQWMYKNFALTGMNVKAGRLWNMLTSAFSHQDFIHLFMNALGLYFVTPIIISTTAMLVSPRRVVPAFWGLYLGGALASACTILWWHRDSPRFVTTGASGALYAMMGYQVILSPRLPVQLYFFIPMQLRVLIAAITAYDVYNLLYNPRSTTSSEGHLGGLAFGIAAGLVLRRMTGYTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U787</accession>
    <name>A0A1Y1U787_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_653921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868171.1">
        <property type="nucleotide sequence ID" value="XM_022018724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U787"/>
    <dbReference type="FunCoup" id="A0A1Y1U787">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U787"/>
    <dbReference type="GeneID" id="33560533"/>
    <dbReference type="InParanoid" id="A0A1Y1U787"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="405"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="790" mass="86873" checksum="C5CCB00CF070382F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7M3</accession>
    <name>A0A1Y1U7M3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_595019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868319.1">
        <property type="nucleotide sequence ID" value="XM_022013839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7M3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7M3"/>
    <dbReference type="GeneID" id="33555647"/>
    <dbReference type="InParanoid" id="A0A1Y1U7M3"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="410"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="687" mass="77192" checksum="AB707B378A33C8C6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U830</accession>
    <name>A0A1Y1U830_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic spindle checkpoint-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_584824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868014.1">
        <property type="nucleotide sequence ID" value="XM_022013709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U830"/>
    <dbReference type="FunCoup" id="A0A1Y1U830">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U830"/>
    <dbReference type="GeneID" id="33555517"/>
    <dbReference type="InParanoid" id="A0A1Y1U830"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="218" mass="24512" checksum="4833E141F55E9DD8" modified="2017-08-30" version="1">MAQKQATRTNQAITLKGSTAMVTEFFEYSVNSILYQRGVYPSDDFRMVKKYGIPMLITADESVKEYLQTILAQVQEWLMSSAISRLVLAIKSVETDETLERWQFEIHTDEAAANGTAPKEKTSTGAKRKEKTEKEVQGEIREIMKQITSSTSFLPILDGECTFTLLAYTNDSLDAVPATWGDADPHLIDRGKVEQVRLRSFSTNVHSLEAMVAYRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U835</accession>
    <name>A0A1Y1U835_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_636926</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868451.1">
        <property type="nucleotide sequence ID" value="XM_022016954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U835"/>
    <dbReference type="STRING" id="4999.A0A1Y1U835"/>
    <dbReference type="GeneID" id="33558763"/>
    <dbReference type="InParanoid" id="A0A1Y1U835"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="16"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="355" mass="38280" checksum="B7CF0A9550D1C5CE" modified="2017-08-30" version="1">MAITHAQGYAVHKPSKDDYKFELTKYELEPLTSDRITVAVECCGVCGSDTHTITGGWGPFETKFVVSGHEVVGKVVEVGDKVTEFKVGDRVGVGAQVSSCKECKACKNDNETYCMGHITHGYNTHWAEGDEHQGGYSTYIRAQEGFVFKIPEALSSNDAASMLCGGLTVFSPLVRNGAGPGKKVGIVGLGGLGHYGVLFGAALGAEVTVFSRSDAKKEDALRLGAKRFVATQNKGFEKDLQQEFDVIISTASASSLPLDELLSTLKIEKKFIMVGMPEDGLKITPQTLSGNAAALASSHLGNSREMRQMLELAAEKGLKPMIEVIPMKDVAQAHKKIQDSSVRYRTVLTQDIEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U848</accession>
    <name>A0A1Y1U848_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_172012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868489.1">
        <property type="nucleotide sequence ID" value="XM_022012089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U848"/>
    <dbReference type="STRING" id="4999.A0A1Y1U848"/>
    <dbReference type="GeneID" id="33553897"/>
    <dbReference type="InParanoid" id="A0A1Y1U848"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="761" mass="85567" checksum="FA877E6655D4213F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8C0</accession>
    <name>A0A1Y1U8C0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868536.1">
        <property type="nucleotide sequence ID" value="XM_022018666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8C0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8C0"/>
    <dbReference type="GeneID" id="33560475"/>
    <dbReference type="InParanoid" id="A0A1Y1U8C0"/>
    <dbReference type="OrthoDB" id="2563900at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="557" mass="56306" checksum="9A595C462C0DB50A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8W2</accession>
    <name>A0A1Y1U8W2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868726.1">
        <property type="nucleotide sequence ID" value="XM_022016856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8W2"/>
    <dbReference type="GeneID" id="33558665"/>
    <dbReference type="InParanoid" id="A0A1Y1U8W2"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="337" mass="35625" checksum="06C836CF5C9C97DB" modified="2017-08-30" version="1">MDLSALGTTLPPGLADAERDMGDKFRAAALSITNLYKSSLNYTKQAYHAGYAACLADVLSTVQSSIAGSQDATQTLSRLMDWAEARETAMAAFAAEEGEDGPAHPSANVKRATMVKEAQQSLARLGHPSRPTSAPIVESTRSEATPSTGLKFMPIVTPASDASSSSLSYQPTPHVRSSSPSMPSSSSASRPMVNMQQQRKRHSPMRSLHRTDTSSSTTSTLPTVSIFNPALTNLPSHQSALSSPTPHLPAGSKRTHQQVDFEMSETEPSGNASVVPPTTPSNRSHRSNKRRTLGTGLGRSSMEDGAVEEKERDNRRKGGRRGHGQGGGGGQGQAGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U903</accession>
    <name>A0A1Y1U903_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_155052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868773.1">
        <property type="nucleotide sequence ID" value="XM_022012040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U903"/>
    <dbReference type="STRING" id="4999.A0A1Y1U903"/>
    <dbReference type="GeneID" id="33553848"/>
    <dbReference type="InParanoid" id="A0A1Y1U903"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="568" mass="63921" checksum="DAEBD6785A0B3672" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U927</accession>
    <name>A0A1Y1U927_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_653301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868791.1">
        <property type="nucleotide sequence ID" value="XM_022018639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U927"/>
    <dbReference type="STRING" id="4999.A0A1Y1U927"/>
    <dbReference type="GeneID" id="33560448"/>
    <dbReference type="InParanoid" id="A0A1Y1U927"/>
    <dbReference type="OrthoDB" id="3363836at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="596" mass="63178" checksum="A55E979EE74E34A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9L8</accession>
    <name>A0A1Y1U9L8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_634718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868971.1">
        <property type="nucleotide sequence ID" value="XM_022016752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9L8"/>
    <dbReference type="FunCoup" id="A0A1Y1U9L8">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9L8"/>
    <dbReference type="GeneID" id="33558561"/>
    <dbReference type="InParanoid" id="A0A1Y1U9L8"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000077">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="281" mass="30766" checksum="720A81322E9C7FC5" modified="2017-08-30" version="1">MISYHHLTLATSTTMTLPMASSSKPRRVIIGVLALQGAFIEHIHYLERLRIPNTVIRAIPIRTADQLESCEALIIPGGESTVIQSVAERTEGLLPILLDFVRNPQRAVWGTCAGMILMAEEDGIGGGKVIKGRPPQKGWGGIEGLKVWRNLYGTQLESFEAHMEIPALSQPTKPFNCIFIRAPAVHSLQPKSTSVADLTQDLHHTIAPTETSTTIEVLATLPSECTPPPPPQDSHLGPSNHEDLGKVMIRQGSKLVTSFHPELSGDTRIHQYWVEKCVLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA05</accession>
    <name>A0A1Y1UA05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869100.1">
        <property type="nucleotide sequence ID" value="XM_022018611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA05"/>
    <dbReference type="GeneID" id="33560420"/>
    <dbReference type="InParanoid" id="A0A1Y1UA05"/>
    <dbReference type="OrthoDB" id="3641682at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013208758" evidence="2">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="27002" checksum="FF96F40385EC64F2" modified="2017-08-30" version="1">MFSIITLPLLAAIIAAETIVLPTYDASDLPHLQGYRQGAFGPQPPHIQGKQQGAFSRRQGASGWGSNGAGGCSVSRGVATNPSDGSPGDGDPHQNYYHIQISEPISCGNGNCSVDETEANSYNIGFQVGSNSNFKPGEVAEWFQPAFSVQESWKTGQKYKCDGNPNGRVAIWQNVAHTAYSVWNTPSGNCGYSNSDYDTYVNIYRAPNQENVGGGFYCVRDDGSGYVRNQGDGYWEGGCAGGPQAYCGNGNVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ2</accession>
    <name>A0A1Y1UAJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_160954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868827.1">
        <property type="nucleotide sequence ID" value="XM_022012058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ2"/>
    <dbReference type="GeneID" id="33553866"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="27757" checksum="94C91FC870BC976C" modified="2017-08-30" version="1">MSLILFEGTVAQVPASASAPFGSGSTILTPNNRIQLSSLQLHQSGDVERLYDEEVTTLQDAIGSQSFAREAWPEGVILDSARIGGDPAFFLFRREPEDITTGTGELTESGEQCKSTSGSFERWGTVNDWQDEQEEDDVVAESPGHETVSSQESVEIVMSWLADGSEAREIRGKLQYESTDCSALVLPSEGLLARDSVHSFKTLSIKKVGIFPSERPSHEPYQALIAIIYEPKYDHFVSVLGAGLPSPETDTQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAL7</accession>
    <name>A0A1Y1UAL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_682976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869285.1">
        <property type="nucleotide sequence ID" value="XM_022019171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAL7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAL7"/>
    <dbReference type="GeneID" id="33560980"/>
    <dbReference type="InParanoid" id="A0A1Y1UAL7"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="471"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="715" mass="74622" checksum="EA034B395ECF6147" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAU7</accession>
    <name>A0A1Y1UAU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tat binding protein 1-interacting protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_123566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868879.1">
        <property type="nucleotide sequence ID" value="XM_022011968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAU7"/>
    <dbReference type="FunCoup" id="A0A1Y1UAU7">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAU7"/>
    <dbReference type="GeneID" id="33553776"/>
    <dbReference type="InParanoid" id="A0A1Y1UAU7"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="8">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="274" mass="30154" checksum="2192627196295038" modified="2017-08-30" version="1">MPPKAAAKEKAVKGDEAEELVLQYLKSTNRPYASADVSANLKGKVPKPAAQKILTTLAEKGSLTMKTYGKQTIFVYDQSHLTALSKEDLAALDIEIKQTSADLESTRKTLRSVQSDLSAQESQPKTKDLEGEIALVEADNASSLRVLLPLRGTGEGPKVEPMSAEEIKKVDALFLKWRKEWINRRKVYKELLGLLQDAGQVRDKMIFEDEQGISPDDEVAREVENGEFCQQGSARGPIRPTMTVKKVNTDTSVAKRSSSTPDPAEGKKKKVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAW4</accession>
    <name>A0A1Y1UAW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_122298</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869389.1">
        <property type="nucleotide sequence ID" value="XM_022011960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAW4"/>
    <dbReference type="FunCoup" id="A0A1Y1UAW4">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAW4"/>
    <dbReference type="GeneID" id="33553768"/>
    <dbReference type="InParanoid" id="A0A1Y1UAW4"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="373"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="471" mass="52598" checksum="9F572EAE21631623" modified="2017-08-30" version="1">MSTVTFENVFHGDSSQVGKLRFNAAGFGWKSYENEENQPTTFSGSDLRSAAWLRVARNFQLRLTMRQADRAKVTFDGFKREDFDKVKRTLDDYFHIKVESRDPALRGWNWGRATIDDGELSFQVQNKTAFELPLASVTNSNIAGKNEVALEFTPPSFDIKPGSSTRQPDELVEMRFYIPGKSMKKNGGGSDAGSDADAEGEETDRDEDGNEISAAEAMHNLIKDKADIGAVVGDSIVVFDEVLILTPRGRYSLEFFQDSLRLLGKSTDYRIPFTSLYRMFLIPKLDDIHVQLVIGLDPPIRQGATRYPFLVAQWPKDEEVDAELNLSDEDIAKYPDLQRKYEAPTFQVISRVLKSLSGKKVTPPGSFRNAQGMNGIKANVKAVQGELYFLEKGLIFIAKQPILIDFGKTESISFSRVGGGIASAKTFDMRVVSRTDAADHVFSAISKEEVQPISTFLQSKNRGQRRGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC20</accession>
    <name>A0A1Y1UC20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_633687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869252.1">
        <property type="nucleotide sequence ID" value="XM_022016646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC20"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC20"/>
    <dbReference type="GeneID" id="33558455"/>
    <dbReference type="InParanoid" id="A0A1Y1UC20"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="552" mass="61269" checksum="B280EFD54BB3A6F3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC76</accession>
    <name>A0A1Y1UC76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_582477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869353.1">
        <property type="nucleotide sequence ID" value="XM_022013560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC76"/>
    <dbReference type="GeneID" id="33555368"/>
    <dbReference type="InParanoid" id="A0A1Y1UC76"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="73"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="547" mass="60177" checksum="EE8443762537FFA5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCA9</accession>
    <name>A0A1Y1UCA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_683158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868957.1">
        <property type="nucleotide sequence ID" value="XM_022019174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCA9"/>
    <dbReference type="FunCoup" id="A0A1Y1UCA9">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCA9"/>
    <dbReference type="GeneID" id="33560983"/>
    <dbReference type="InParanoid" id="A0A1Y1UCA9"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="178"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="461"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="519" mass="56652" checksum="C50B78B4CFAF21C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCE0</accession>
    <name>A0A1Y1UCE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_121250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869382.1">
        <property type="nucleotide sequence ID" value="XM_022011958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCE0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCE0"/>
    <dbReference type="GeneID" id="33553766"/>
    <dbReference type="InParanoid" id="A0A1Y1UCE0"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000428">
        <property type="entry name" value="Related to WHI3-involved in regulation of cell size"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="698"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="815"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="987" mass="101664" checksum="9990E53214145EEB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD61</accession>
    <name>A0A1Y1UD61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_632952</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869654.1">
        <property type="nucleotide sequence ID" value="XM_022016578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD61"/>
    <dbReference type="FunCoup" id="A0A1Y1UD61">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD61"/>
    <dbReference type="GeneID" id="33558387"/>
    <dbReference type="InParanoid" id="A0A1Y1UD61"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="121"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="302" mass="32746" checksum="7C182DD7D1BEE5FF" modified="2017-08-30" version="1">MSPPADIKGRKRESGAARVLGSGTSGIAELLVFHPVDTVAKRLMSNRTNVSFGNLNTIIFKSAAQSPIHQKFLSLFPGLGYAAGYKIAQRVYKFGGQPYFRDLIDKNGGDYFRNTFGKKWGGLMMHATAGSLTGMGEVVLLPLDVLKIKMQTNPDALRGRGFFRLLSEEGIGSLYKGWGWTIARNVPGSFALFGGSAVTKEYLFHLEDYSSATWGQNFVASITGAVASITVASPLDVVKTRIQNANFNSSEGGFAIIREMVKTEGVSAFFKGLTPKILVVGPKLVFSYTLAQSLIPFFGKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD81</accession>
    <name>A0A1Y1UD81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_581472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870130.1">
        <property type="nucleotide sequence ID" value="XM_022013505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD81"/>
    <dbReference type="FunCoup" id="A0A1Y1UD81">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD81"/>
    <dbReference type="GeneID" id="33555313"/>
    <dbReference type="InParanoid" id="A0A1Y1UD81"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="13">
        <location>
            <begin position="16"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="198"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="523" mass="58580" checksum="A51E1EBB7E8C0614" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDQ0</accession>
    <name>A0A1Y1UDQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Long-chain-fatty-acid-CoA-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_642867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869810.1">
        <property type="nucleotide sequence ID" value="XM_022017511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDQ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UDQ0">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDQ0"/>
    <dbReference type="GeneID" id="33559320"/>
    <dbReference type="InParanoid" id="A0A1Y1UDQ0"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="100"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="704" mass="77298" checksum="7F394151986C0F4A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDS8</accession>
    <name>A0A1Y1UDS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_71992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869861.1">
        <property type="nucleotide sequence ID" value="XM_022019225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDS8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDS8"/>
    <dbReference type="GeneID" id="33561034"/>
    <dbReference type="InParanoid" id="A0A1Y1UDS8"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="212" mass="23887" checksum="67676AA6FFFF9E6C" modified="2017-08-30" version="1">MLHLVRATRLQATVGASLLNNSARAFSSSALSLKYTKSQREELELHGLQPPPKAPTLPYGAFVRDFYANGSGGDKVPVTQASAEIKEAWGKLSAAEKSKYQEEYKQARQRYQQEFETYMASLSKKDLNNVEKIIGRIRMPGGRQAATNKDGEPRKVSGYIKFSQDLRSSGKIDIEQWTGRDRVIEFAKEAGRQWKALDQSERDSWNQRAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDT0</accession>
    <name>A0A1Y1UDT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_581097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870301.1">
        <property type="nucleotide sequence ID" value="XM_022013483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDT0"/>
    <dbReference type="FunCoup" id="A0A1Y1UDT0">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDT0"/>
    <dbReference type="GeneID" id="33555291"/>
    <dbReference type="InParanoid" id="A0A1Y1UDT0"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="27577" checksum="ED36C7450C846EF5" modified="2017-08-30" version="1">MAEGARGGFGRGRGRGRRGPRRGGKKDEEKEWVPVTKLGRLVKDGKIKSMEEIYLFSLPVKEFQIVDTFLPTLKDEVMSIHPVQKQTSAGQRTRFKAFVAVGDFDGHVGLGVKCAKEVATAIRGAIIVAKLSIVPVRRGYWGAHIAEPHTVPCKVSGKSGSVMCRLIPAPRGTGIVAAPAPKRMLQMAGIQDCYTQAKGSTATQGNFLKATMTALSKTYQFQSPDLWTIIPPGQNPLDEHSVHLQIAARKNAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE20</accession>
    <name>A0A1Y1UE20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_628027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870340.1">
        <property type="nucleotide sequence ID" value="XM_022016072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE20"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE20"/>
    <dbReference type="GeneID" id="33557881"/>
    <dbReference type="InParanoid" id="A0A1Y1UE20"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012598418" description="carboxypeptidase C" evidence="7">
        <location>
            <begin position="18"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="466" mass="52540" checksum="1718AB60D8DA50DD" modified="2017-08-30" version="1">MHLPLALLSLAVSPTYARPQQQPWRALPETIAKPRLCPDSNFTQYSGYVPGSEIFFWFFPSRSDPSKDPIGVWTNGGPGSSALMGMQYVGPCEVVEGDHGPEMRRREWSFNDHASILMIDNPRGAGFSFAKFPAVDNIYDGARDAWIFLQSFFKVFPEYQANALAVNSASYGGHYCPAYASFIQHMNAKIAGEPSLWEDIWEDEATDDAIRLNLTSISIGNGFINNRVQARFNIEYACGGADIPMLGDAEECEWARKQIDMAEELMDTCRSKVECSAAGLWTDKVSSFPYETTGLNPYDYRRSEPYDETHIIAFYNNASVQAALGVIQPGQPAKVWESHSRRVAAEFILSGDWDERTDYLFARLLKSGVGILKYEGMVDWICNYLGVRQVMQNLTDYQHQKAWNRIDMKPWYGQGDVSAGRYKCHQHNGEAPLCYVEVEDAGHVVSTDKPKEGSWLVGKWMNDREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE43</accession>
    <name>A0A1Y1UE43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_642932</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869940.1">
        <property type="nucleotide sequence ID" value="XM_022017516.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UE43">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE43"/>
    <dbReference type="GeneID" id="33559325"/>
    <dbReference type="InParanoid" id="A0A1Y1UE43"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 16" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="540"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
        <location>
            <begin position="786"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1244"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1249"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1281"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="15">
        <location>
            <position position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1311" mass="146971" checksum="93E7FE030B1B7C0F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEG5</accession>
    <name>A0A1Y1UEG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870480.1">
        <property type="nucleotide sequence ID" value="XM_022018362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEG5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEG5"/>
    <dbReference type="GeneID" id="33560171"/>
    <dbReference type="InParanoid" id="A0A1Y1UEG5"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="351" mass="37561" checksum="4A1E122453155AAF" modified="2017-08-30" version="1">MSVIKTPITDMFGIQHPIMLAGMNVAAGPELAAAVSNAGGLGVIGGLGYTPKQLRNIIKEIKSSLKSPDLPFGVDLLIPSLGPNARKTNYDYTKGHLDELLTVIIEEKAKLFVCAVGVPPKEAVKRLHDHGIICMNMVGHPKHVQKALDVGMDLICAQGAEGGGHTGRTPYSVLIPACVDICKGKKSPLTGGPVHVIAAGGIYDGRGLASALMYGAQGVWVGTRFVASTEAGAPKKHKDLLVSADHGDTDTTLIYTGRPLRVRQTDYVKSWRGREEEIKNLTSQGKIPHEVELEKHPEKSMEGRMWLMGEVSALINDIKPAKEIIDEMVKDAKTCIENGGTLLAGKSRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEN5</accession>
    <name>A0A1Y1UEN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_580845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870604.1">
        <property type="nucleotide sequence ID" value="XM_022013469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEN5"/>
    <dbReference type="FunCoup" id="A0A1Y1UEN5">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEN5"/>
    <dbReference type="GeneID" id="33555277"/>
    <dbReference type="InParanoid" id="A0A1Y1UEN5"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="483"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="792"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="853" mass="94465" checksum="7435773C4191C24D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UET5</accession>
    <name>A0A1Y1UET5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_591847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870600.1">
        <property type="nucleotide sequence ID" value="XM_022013805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UET5"/>
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        <property type="interactions" value="873"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UET5"/>
    <dbReference type="GeneID" id="33555613"/>
    <dbReference type="InParanoid" id="A0A1Y1UET5"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000102">
        <property type="entry name" value="Chromosome organization and biogenesis-related protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="556"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="936"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128885" checksum="699AE0CD73C4DD51" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF12</accession>
    <name>A0A1Y1UF12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_626699</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870730.1">
        <property type="nucleotide sequence ID" value="XM_022015924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF12"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF12"/>
    <dbReference type="GeneID" id="33557733"/>
    <dbReference type="InParanoid" id="A0A1Y1UF12"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="19">
        <location>
            <begin position="34"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX36661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="421" mass="47515" checksum="D20CB4298464A646" modified="2017-08-30" version="1">MSDRPGPADAGPPSVPFRRPLVPKVSQVDAEALDESLVDMLSERVERSLGTITSNLSFDLKPEINLALKLIIFKHGIWTSLSSPGSDMVNIRLSSAKHGRPSRRILLLYLLLSPPIFPTYLLTRFREYALSKQWPDLPRRDLRKRIWSLITKLEVASKAWELVGWIWFLIDPRYPSLLMRILKLQYTASSDHVARLVSYEFMNRQLVWSVFTEFLMYSIPLLPSVPPFLSPATLTSHISRFFHQPTGINYQSIPLLPASSKGRKKSRALTGVLAHLPRTICPVCHLRQTAIPVPLSDTQAGSDIPLPPLPISADPTVPQDILRITEDNDETVIFSPARSDCWGECAYCYYCIKGELVKHKMALDQEMAVIRDEKQREACKARKWSCLRCGGEVSRAWRVLSAVNGDSSVSIDADQERDPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF70</accession>
    <name>A0A1Y1UF70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_461581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870762.1">
        <property type="nucleotide sequence ID" value="XM_022012852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF70"/>
    <dbReference type="FunCoup" id="A0A1Y1UF70">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF70"/>
    <dbReference type="GeneID" id="33554660"/>
    <dbReference type="InParanoid" id="A0A1Y1UF70"/>
    <dbReference type="OrthoDB" id="2576338at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44094" checksum="42B44045DF2CBEE4" modified="2017-08-30" version="1">MSDYLARKALAEQLQRKKEAQFQAELEAKRLKDKQAALEEEERKKQRELQSKELRRKELLRANEAMVKASASKGQAGPSSQAGPSKVSASSSLAPSIAGRPSASEAKEIEYNPFAEDEYRPRPLSFSLEKPLIKRLEAKKAANDQKASSTSRANRGGTKSSDTKKRNTERKGSPPPLGRKAKAALAFAQSAKASKFDSVFSVRSIVDKAASPSNSPKLASGSLPRSAATPSKLSNGSSKVAASHINGNGKAREDPSLRPKADGMGRNGPRNTIGKAAAAHPSRRRRDSNDSTTTSEDSDRPAKRTRPDLDRPRGKERFGGGHSGPSQSAISAEIQALFRRPGQTRKEYDDYSDGSSDMEAGLSDVEEEELQAARIARREDELAEREEAERRRRKEEMKRQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF78</accession>
    <name>A0A1Y1UF78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_459936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870741.1">
        <property type="nucleotide sequence ID" value="XM_022012845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF78"/>
    <dbReference type="GeneID" id="33554653"/>
    <dbReference type="InParanoid" id="A0A1Y1UF78"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012237358" evidence="2">
        <location>
            <begin position="23"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="350"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="622" mass="65673" checksum="F84F4A21C45302D5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFJ5</accession>
    <name>A0A1Y1UFJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_627198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870867.1">
        <property type="nucleotide sequence ID" value="XM_022015972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFJ5"/>
    <dbReference type="FunCoup" id="A0A1Y1UFJ5">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFJ5"/>
    <dbReference type="GeneID" id="33557781"/>
    <dbReference type="InParanoid" id="A0A1Y1UFJ5"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="317"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="643" mass="70952" checksum="9B4D128366E1CE36" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFP1</accession>
    <name>A0A1Y1UFP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_627373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870907.1">
        <property type="nucleotide sequence ID" value="XM_022015992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFP1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFP1"/>
    <dbReference type="GeneID" id="33557801"/>
    <dbReference type="InParanoid" id="A0A1Y1UFP1"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="35703" checksum="4711829CD5866B1F" modified="2017-08-30" version="1">MYAIQFSPLHPTFGAEVTSADFSRPDQHLVDQLKEGLAKYGVLVCRQTGLDDDRHVAMSRLFGELDDVTPYTRLGRINRLKYDELFDVSNVDGEGNIMQPDSQRAILGKGNGLFHVDSAFNPRRAGYSLLLAHELPPMGHGGNTEFADTRTAYDDLDEATKRRIQDWILWHSQHHSRRKANPGVEFLDDPKFLPESYPFGKHKLVQFHEPSGRTNLYIANHAYKVQDLPLEQGQAEIQRLLNHASQHKYILSVDWRDPGDLVMWDNTCVMHRVTGGTFEGKFRRDMRRTTVHDSSAYAWGENTVGDTWRSGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFS2</accession>
    <name>A0A1Y1UFS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870947.1">
        <property type="nucleotide sequence ID" value="XM_022018322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFS2"/>
    <dbReference type="GeneID" id="33560131"/>
    <dbReference type="InParanoid" id="A0A1Y1UFS2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="27222" checksum="60E1691DA34A1701" modified="2017-08-30" version="1">MDSSYARQQSAHHRSQLTTLLSTFPSSAPPHTTQSQMFQVPRVNTGSSLNTTLGTSLDGRSLSTHIATTNPTSSSPSSSSSPFGPSARSDRPNRSSGQQQTKVSRDTPDSPPSTHVAANELSLSTQGISPTCGNAFSIATEPGSAITSGSQSLSGSLTGTTIDTPIPSPAPRLPTPLHKSPIDFIDSLNMGLKGSPDYPLPSQSYGGSVDANGVFNDAYTMLSQWTPGYGFGSLAVPPHGHAPQNTFAFVADSLNMNRTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFW5</accession>
    <name>A0A1Y1UFW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_651432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871029.1">
        <property type="nucleotide sequence ID" value="XM_022018336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFW5"/>
    <dbReference type="GeneID" id="33560145"/>
    <dbReference type="InParanoid" id="A0A1Y1UFW5"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="492"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="673" mass="72478" checksum="DAD76BEC2672BFE0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFX6</accession>
    <name>A0A1Y1UFX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">triacylglycerol lipase</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_651443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871039.1">
        <property type="nucleotide sequence ID" value="XM_022018339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFX6"/>
    <dbReference type="GeneID" id="33560148"/>
    <dbReference type="InParanoid" id="A0A1Y1UFX6"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013434706" description="triacylglycerol lipase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="443" mass="46421" checksum="96B66C040F801CDB" modified="2017-08-30" version="1">MILPYLLQTLWATASALPVTGLFARGGQASPLDPFYISPGNVQGSPLGTVLRSRTFQPIYNDRPLNATGYQLLYVTQGANTTKFAATTTIFKPTQPNGNLITYAEPYDADSTACAPSAAYLGGGWSTTSDDETLYMIGFLDQGYIVNSPDYEGPDSAYSAGILSGHAVLDSVRAVLSYGPIGLNANTQVAGVGYSGGAIATGWAAALHASYAPSINVVAWSVGGTPADLLACIQNLDGGPYARLAIGGIFGQSQAYQAIADLLSASLTSIGLSARNTTFNGCKSPTVALDFAFQHFLSTEYQSYGSQLVYQPAFAGPLSQQLLGQDPNLVPVAPIRVFHALHDEVIPYATVQKMVNSWCANGIKSLIFETDEGASEHGTEEILQLANVFNWVNSRMNGTAPPVGCQITTTVLPLLDAGALPAAVSWAAGIANTLITSNTTPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG42</accession>
    <name>A0A1Y1UG42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 7">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_422390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 7"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871069.1">
        <property type="nucleotide sequence ID" value="XM_022012735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG42"/>
    <dbReference type="FunCoup" id="A0A1Y1UG42">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UG42"/>
    <dbReference type="GeneID" id="33554543"/>
    <dbReference type="InParanoid" id="A0A1Y1UG42"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="10">
        <location>
            <begin position="191"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="11">
        <location>
            <begin position="364"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="570" mass="62815" checksum="902A796DFEFD8E48" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGC3</accession>
    <name>A0A1Y1UGC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_652018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870244.1">
        <property type="nucleotide sequence ID" value="XM_022018425.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGC3"/>
    <dbReference type="GeneID" id="33560234"/>
    <dbReference type="InParanoid" id="A0A1Y1UGC3"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="443"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="982"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1104"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1288"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1378" mass="150578" checksum="EDF56E806F08A4D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGG8</accession>
    <name>A0A1Y1UGG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_429378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871198.1">
        <property type="nucleotide sequence ID" value="XM_022012766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGG8"/>
    <dbReference type="GeneID" id="33554574"/>
    <dbReference type="InParanoid" id="A0A1Y1UGG8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012711277" description="Secreted protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14723" checksum="C64D4BC02C5F7654" modified="2017-08-30" version="1">MVGEKESQRSPDRCSMLLAGCWLLLQLLAAARCCPGQPETNSNRLIEIEILLWPSTCCSWEFIRAWWTSPYSVVRDWRHRRAVVAYNSRVLPQVERRGRGGSSLVRISRVHQHAKMKKPYIETSQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGK3</accession>
    <name>A0A1Y1UGK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_608491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871137.1">
        <property type="nucleotide sequence ID" value="XM_022014114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGK3"/>
    <dbReference type="GeneID" id="33555922"/>
    <dbReference type="InParanoid" id="A0A1Y1UGK3"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214741" description="DUF4185 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="46618" checksum="6414EB0DED54D1FF" modified="2017-08-30" version="1">MLGQTLVALTSSAMAFAAPATVPRQERGLPAVSLPIANPLAPASFGSSKIAVTIDPNLQRDSCVTANALIDGRVLWICRDSLSLKNETLGQYAGFFTSSSASWSNQTTGTTSSGGSGNQPKLDFVPLTQGQQFVTAGYLQQLTQYGGPFPLPSPYLPYAADQCPDSGGGCYGGRYIEWPDASMYVTDVASDGTTTGYLYTTAAAGGGNLTDNFPGTTLYKITYTPTADIDTLPEVTMIAEHFFPRFGFNYGAFGGVVSPTDGLLYLWGETYDFSPAAYNISIGLARVAIDSIENPDAYSYYYPASNTWSSTQPTIYDSAANMTVGGIYGQGTFYYNSKHSAYFFVGQSQNGLMNVSYTVANTPEGPWSPMAEPVTLSTDFAYSFAAHPQMGHDPDQLYCSFTNNIDDPTVGNVYQQPLYLINFNGSSLAGVLSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGZ2</accession>
    <name>A0A1Y1UGZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_590603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871361.1">
        <property type="nucleotide sequence ID" value="XM_022013791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGZ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UGZ2">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGZ2"/>
    <dbReference type="GeneID" id="33555599"/>
    <dbReference type="InParanoid" id="A0A1Y1UGZ2"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="238" mass="27201" checksum="63CED62D7D0BFD44" modified="2017-08-30" version="1">MGYLHNALQKVGLAQPGPKITQQDRAILDLKLQRDKLKQYQKRLQAVLDKEQEIAKRALKEGNKKRALTALRQRKYQEQLLSKTDGQLQTLQELVSTIEFSQIQAAVLHGISVGNEVLKQLQSEMSLEKVDKLMEETREGIEYQREIDEALMSRMSPEEEEAVQEELAQLEREAFVRPCAEWGWFPKARLPQPAIPSVPEQQPVTLPEAPQTEPMEPVKVQQPGERSERASALIFGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHL1</accession>
    <name>A0A1Y1UHL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_650633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871055.1">
        <property type="nucleotide sequence ID" value="XM_022018178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHL1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHL1"/>
    <dbReference type="GeneID" id="33559987"/>
    <dbReference type="InParanoid" id="A0A1Y1UHL1"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="154" mass="17390" checksum="BBE633F6CD9AFE88" modified="2017-08-30" version="1">MTFAAGYWHWFWLIQPAPGPEDTILSSPDTYWRMKMGTPESTSSYWSEEDVDVYGALMSDRSAVHAACEDYRAAASIDLDHDQADYDEGKRIHTPLRILWGRHGMVEKLGKAVDIWQDFASADVKVSGSALACGHEIPEEVPKDLLEEIHSFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHP5</accession>
    <name>A0A1Y1UHP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_622508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871567.1">
        <property type="nucleotide sequence ID" value="XM_022015480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHP5"/>
    <dbReference type="FunCoup" id="A0A1Y1UHP5">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHP5"/>
    <dbReference type="GeneID" id="33557289"/>
    <dbReference type="InParanoid" id="A0A1Y1UHP5"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000388">
        <property type="entry name" value="Putative RING zinc finger domain superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012214740" description="RING-type domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="453"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="591" mass="64256" checksum="EA895B0014B536B1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI37</accession>
    <name>A0A1Y1UI37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_579245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871636.1">
        <property type="nucleotide sequence ID" value="XM_022013367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI37"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI37"/>
    <dbReference type="GeneID" id="33555175"/>
    <dbReference type="InParanoid" id="A0A1Y1UI37"/>
    <dbReference type="OrthoDB" id="3174109at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="660" mass="74770" checksum="7C169A6B356CAE72" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI52</accession>
    <name>A0A1Y1UI52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XAP5, circadian clock regulator-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871730.1">
        <property type="nucleotide sequence ID" value="XM_022015552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI52"/>
    <dbReference type="FunCoup" id="A0A1Y1UI52">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI52"/>
    <dbReference type="GeneID" id="33557361"/>
    <dbReference type="InParanoid" id="A0A1Y1UI52"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="187"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="37423" checksum="21045218E6959FC6" modified="2017-08-30" version="1">MAGGPPEETLPHVYLARQREREAAEHQRQKDAILKESQKDHTADRFIGITENIDEKLKKSTIGLVTLDDFKKTREDLEEEQRQRAAQSAAEKSGGPSKSKRSKKKEKVKLSFAEDEDEVSSDLDSKKRSRPGSEGQEDVPSTKRIAKNPSVDTSFLPDRDREEEERLQREDLRKEWLAKQELTKSEAIEVTYSYWDGSGHRKTVECKKGDDIATFLGKCRSQVSELRGTSVDNLMYIKEDLIIPHHYTFYDFIINKARGKSGPLFNFDVHDDIRMVADATVEKDESHAGKVVQRSWYNRFKHIFPASRWEVYDPDKNYGHYRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIH8</accession>
    <name>A0A1Y1UIH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_444141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871395.1">
        <property type="nucleotide sequence ID" value="XM_022012798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIH8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIH8"/>
    <dbReference type="GeneID" id="33554606"/>
    <dbReference type="InParanoid" id="A0A1Y1UIH8"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="194" mass="22077" checksum="C6AEC61FDAFAB82F" modified="2017-08-30" version="1">MLDPFLTTFVSTMADASELANTLFPPPPPFYKEFTDANLARYAELRGEPSGTSKNRASSPISADTPELRDLESKLERPRADWIVEEGRWMCFGQQYDVEPRIPSLEQIGLTRWIDPNEPPHTSLPPLLHSFLHTFLLLLDTLTNTARIPGELEEKGWQHEGDQYIQHMSNLAATMMVASNQLRDVQVRKTSRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIR9</accession>
    <name>A0A1Y1UIR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_625987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871432.1">
        <property type="nucleotide sequence ID" value="XM_022015860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIR9"/>
    <dbReference type="FunCoup" id="A0A1Y1UIR9">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIR9"/>
    <dbReference type="GeneID" id="33557669"/>
    <dbReference type="InParanoid" id="A0A1Y1UIR9"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="786" mass="86665" checksum="E3912CDA6E2F2C0C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIX0</accession>
    <name>A0A1Y1UIX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871906.1">
        <property type="nucleotide sequence ID" value="XM_022015629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIX0"/>
    <dbReference type="GeneID" id="33557438"/>
    <dbReference type="InParanoid" id="A0A1Y1UIX0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="382" mass="44367" checksum="2323DE09C8F34ECC" modified="2017-08-30" version="1">MPKKPITPSTEPGWRRLTIPRKRPRSPNPPLSTPRPFNAEIFGNIARILIDEGDTTDTESFALANSTCFHAVVPRRWHCVKLRSPEAVLALLSGLQAVSQKRESSSDAGQNCAKSQRYEFYLACMRHLDIDLESWYHTSAEKKGPSELEYWQPLTDNPPELRELIALDTLRVETIDIYDGSVIWLNMVFSCFQARHLQWQAQNLAEEWYDWGIWGESRDKIVETLSLRWDTERLESYDVPIPCPLLPSEKFRMVISGRIVWDLPSVLRSVWWKEVGYEIISAYMTDKGCNHKVSLRGPVWLVLSPLENFRNITNYFPTEPVSVDQLESVPEEWFEFVHVPFDTFEDLGDLWRACVKLDIWSEAQAEDREEDFMRLVCPEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIX2</accession>
    <name>A0A1Y1UIX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_624208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872000.1">
        <property type="nucleotide sequence ID" value="XM_022015667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIX2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIX2"/>
    <dbReference type="GeneID" id="33557476"/>
    <dbReference type="InParanoid" id="A0A1Y1UIX2"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF53">
        <property type="entry name" value="ENDO-4-O-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="504" mass="57423" checksum="A842089206920BAF" modified="2017-08-30" version="1">MPQNVLLIIADDLGKYINSYGCQSVTTPNLTKFTDEAVRFTHAFACTPSCSGSRSTIFTGLHTHENGQYGLAWGPHGHFQTYEHVESMPRLFNEAGYLTGVLGKVHVGPPAVYPWKWMRESESRDVAWIADQAKEFFQEAGSDAFHLTVAFHDPHRDVKSRGGFANDWKYDPRVELLDVKESQVEVPPWLTDCAETRQELVEYYKAIHRFDQGVGMVLQALADSGLADSTLVMITSDNGPPFINSKTTLYEAGIDLPLLIRRPGGPKGIVNPNMVSFTDLLPTMLDWAQIRPKMSDQDTEIHLFKASPSPRRGRSLLSILSDHTVVPSPDWQDAVFGSHTFHEFQNYWPTRIMRTRRFKYHRNIAWQLDFPFATDLYASLSFEGIRNLPPPVMLGRRPFKNYIRRSAEELYDIEADPLEVDNLVDNLEYAETLKEMRTALEKWQQTTRDLFLYRDGASIQALIRYERDGLQVPDRFDMNPEEPGTRGPLVKVCADIFENQALAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIX9</accession>
    <name>A0A1Y1UIX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_579272</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871484.1">
        <property type="nucleotide sequence ID" value="XM_022013371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIX9"/>
    <dbReference type="FunCoup" id="A0A1Y1UIX9">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIX9"/>
    <dbReference type="GeneID" id="33555179"/>
    <dbReference type="InParanoid" id="A0A1Y1UIX9"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="12"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="116"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX37446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="311" mass="33876" checksum="852BA9E003D1DD4E" modified="2017-08-30" version="1">MADVVKKPKDVKAFMTDFLMGGVSAAVAKTAAAPIERIKLLVQNQDEMIKQGRLSTPYKGIVDCFGRTYREEGLVSLWRGNTANVIRYFPTQALNFAFKDYFKSLFGFKKSEGYWKWFAGNIASGGAAGASSLLFVYSLDYARTRLANDNKSAKSGGSRQFNGLVDVYRKTLASDGIAGLYRGFVPSVVGIIVYRGLYFGLYDSIKPVLLVGPLEGNFLASFLLGWTVTTSAGLCSYPLDTIRRRMMMTSGGAVHYKSMFDAGSQIIAKEGVRSLFKGAGANILRGVAGAGVLSLYDKLQELMFGKVYSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIZ6</accession>
    <name>A0A1Y1UIZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_626294</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871494.1">
        <property type="nucleotide sequence ID" value="XM_022015881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIZ6"/>
    <dbReference type="FunCoup" id="A0A1Y1UIZ6">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIZ6"/>
    <dbReference type="GeneID" id="33557690"/>
    <dbReference type="InParanoid" id="A0A1Y1UIZ6"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000365">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.14, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="333" mass="36322" checksum="F777AD4A5AA502BA" modified="2017-08-30" version="1">MSTLSSSPPAKRARPNVGSALKKQPVAPPPAVPDFDKGIQYWDEVEASVNGVLGGFGEGPVPHIEQLSSRLLLLSLLPSLHTFPSPLTPFPPPRPKHRLTVLDVGAGIGRVTANTLLPLFEDVVLVEPVQKFIQEGYANARAGKWRDIPAAVTSDNDMSGKGKGNQDLDEGWRGKRVWFLRGGLQTLDPLRPQVGADSLGVLGRSEGGESSEGFGRPEGEVVYDVVWCQWCLGHLSSPELVAFLKRARASLRPDTRTTSDGSYETMLFVKENVCEDGPGGQATEFLDEQDSSLTRSNAKWLEVFREAGLEVIREEVQIGMPSELFVVKTWALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ20</accession>
    <name>A0A1Y1UJ20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_608425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872050.1">
        <property type="nucleotide sequence ID" value="XM_022014112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ20"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ20"/>
    <dbReference type="GeneID" id="33555920"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ20"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012282222" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="202"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="589" mass="65846" checksum="91964C3E092DEC6B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJH4</accession>
    <name>A0A1Y1UJH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_390074</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871641.1">
        <property type="nucleotide sequence ID" value="XM_022012659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJH4"/>
    <dbReference type="FunCoup" id="A0A1Y1UJH4">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJH4"/>
    <dbReference type="GeneID" id="33554467"/>
    <dbReference type="InParanoid" id="A0A1Y1UJH4"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="171"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="33"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX37654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="341" mass="36266" checksum="57209C125621640C" modified="2017-08-30" version="1">MFARQVASRSASLLSRRAFSSSIVAERKVAVLGAGGGIGQPLSLLLKADPLVTSLSLYDIRGAPGVAADCSHVNTHSEVKGFEQDQIKEALTGAEVVVIPAGVPRKPGMTRDDLFNTNASIVQTLAEACAEHCPKAMILIIANPVNSTVPIWAEVYKQKGVFDEKRIFGVTTLDVVRASRFLGEIKNVDPKKVKVTVVGGHSGVTIVPLLSQAPKGRDVKGEEYDALVNRIQFGGDEVVKAKAGAGSATLSMAYAGARFANSVIRAINGEEKVVEPTFVKSPLYESEGVEYFASRVELGTEGVKTIHPVGKLSAKEEELLKACLAELPKNIKKGVDFVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJM5</accession>
    <name>A0A1Y1UJM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_563650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871653.1">
        <property type="nucleotide sequence ID" value="XM_022013025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJM5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJM5"/>
    <dbReference type="GeneID" id="33554833"/>
    <dbReference type="InParanoid" id="A0A1Y1UJM5"/>
    <dbReference type="OrthoDB" id="3337916at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="1">
        <location>
            <begin position="108"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="333" mass="33965" checksum="5F722EC8E7848A6B" modified="2017-08-30" version="1" fragment="single">SVSSAIASLSPSATISADSAVSASASASEAASVAASVAPVSASPAPSASSGGGGGGSYNNASSNAIFPLGTGSASWTTDPDISGALSFDAALNPLTAGSLPTITTAPDGSQAMSATYPAGIVGLKSGGGYSFYSEAEHNGVDVTGASEISFTYSVYFPDGFDFVKGGKLPGVYGGTSLEASKTCSGGRQTDRSACFSARTMWRTNGMGEIYNYLPPGATSANPNYCSIAPMSICNPDYGDSIGRGAFTFATGAWTTISQRFKMNDFGQSNGEQELYVNGESKILISNMAYAQEEGTKIYGIMAQTFFGGSDVSWASPYDQTAYFKDWSMAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKJ3</accession>
    <name>A0A1Y1UKJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_624343</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872044.1">
        <property type="nucleotide sequence ID" value="XM_022015687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKJ3"/>
    <dbReference type="FunCoup" id="A0A1Y1UKJ3">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKJ3"/>
    <dbReference type="GeneID" id="33557496"/>
    <dbReference type="InParanoid" id="A0A1Y1UKJ3"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="334"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="550"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX38057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="710" mass="78640" checksum="A4805EF8FC2755D5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKL8</accession>
    <name>A0A1Y1UKL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative plasma membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_642005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872003.1">
        <property type="nucleotide sequence ID" value="XM_022017461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKL8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKL8"/>
    <dbReference type="GeneID" id="33559270"/>
    <dbReference type="InParanoid" id="A0A1Y1UKL8"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="363"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="646"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="835" mass="93158" checksum="80DBED1A0474658D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL14</accession>
    <name>A0A1Y1UL14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_621902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872594.1">
        <property type="nucleotide sequence ID" value="XM_022015419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL14"/>
    <dbReference type="FunCoup" id="A0A1Y1UL14">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL14"/>
    <dbReference type="GeneID" id="33557228"/>
    <dbReference type="InParanoid" id="A0A1Y1UL14"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="251" mass="27277" checksum="45C44E24135082D5" modified="2017-08-30" version="1">MASQRKFFVGGNFKMNGSMKLIKEIVDQINAANLDGSTEVIVAPPALYLLQVQEMLKKPVEVSAQNCFTEVSGAFTGEISPNQLKDANVHWVILGHSERRSLFGDTDKLVADKVAAALKADLKIIACIGETLEEREKGVTMQVVERQLDAIAGEVKEADWKDIVIAYEPVWAIGTGKVATVEQAQEVHKDIRQWLSKRVSSAVAESTRIIYGGSVNAKNCGELAGPPDIDGFLVGGASLKPEFLDICKVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULM0</accession>
    <name>A0A1Y1ULM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_617944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872804.1">
        <property type="nucleotide sequence ID" value="XM_022014970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULM0"/>
    <dbReference type="FunCoup" id="A0A1Y1ULM0">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULM0"/>
    <dbReference type="GeneID" id="33556778"/>
    <dbReference type="InParanoid" id="A0A1Y1ULM0"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000070">
        <property type="entry name" value="Endoplasmic reticulum protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="455" mass="49488" checksum="AB0B8AC948961199" modified="2017-08-30" version="1">MEVNKEEALRCLAIAQRHRNSSNLPNALRFAKKSVALYSTPEGEAMVVVIEREISTGGSSSNADAGPSSNGTGDTTSKAKASGVEEHVSSAHSRPGHHTEAKTSTSGASSTTPAPKKREYTAKQMEVVTRVKKCKHHQYYEILSLERTCTENDVKKAYKKLALVLHPDKNGAPGADEAFKMVSKAFQVLSDADMRASFDANPSVDPTSRGGGGGGGMYSRGGGGFPPGFGGAGGGFQGELNPEDLFNMFFGGGGGGFGQGANVFTFGGPGGFTTHYGGRARRRTAEAPEESHPMMALIPILLLVFFAIVSILPNITGDHDNTPSYSFEPDQNHHLGRQTFFRGVPYWVNQKEWEGSKVWESVPEARREDKNAALFSTKVKLFERGVENVYINRLHNECDYFNQRVSQQVSEAAGIFGIGADYEKMKELRALKSPACEQLRDWGVLHQQNRQRVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULN7</accession>
    <name>A0A1Y1ULN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_297110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872762.1">
        <property type="nucleotide sequence ID" value="XM_022012414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULN7"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULN7"/>
    <dbReference type="GeneID" id="33554222"/>
    <dbReference type="InParanoid" id="A0A1Y1ULN7"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022423">
        <property type="entry name" value="Neurohypophysial_hormone_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00264">
        <property type="entry name" value="NEUROHYPOPHYS_HORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013231483" evidence="4">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="211"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="345" mass="36482" checksum="BAFB64FEABDA3223" modified="2017-08-30" version="1">MLVIRLSHALSSLSFLVVALGNIHRPPARGFRAHDIVKRQANGHYIGGVLLDVSFGSGYSTASTPSLTSSSSGRARGPLRAGFLDWNLVAISTSSAPDQTSSVAISSSISSHASSPIPTHSSTASITSIRPPQVIHLIEVGSGVAGGNQATYTSNAPPSTTVQSQHVPDLDPDPNPNPHPQSQAPLSAETSSTSVADGVPVPGPTYSGTSGDQAGWVRAHNAYRSQYQAPALTWSDDMMWKAKGNAELCTYGHTNTGENIAWGPDMGPDKVIDMWMSEAPLYDWSHPGYQDPAGHFTQVIWVDSLRVGCYIVNCPDGGQQATCEYDPIGNYVNAGMFQANVKPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULV3</accession>
    <name>A0A1Y1ULV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_302170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872842.1">
        <property type="nucleotide sequence ID" value="XM_022012430.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1ULV3">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULV3"/>
    <dbReference type="GeneID" id="33554238"/>
    <dbReference type="InParanoid" id="A0A1Y1ULV3"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1268"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1318"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1435"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1524"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1566"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1601"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1635"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1705"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1758"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="12">
        <location>
            <begin position="273"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1798" mass="203541" checksum="18F23D76110C3019" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULY5</accession>
    <name>A0A1Y1ULY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872916.1">
        <property type="nucleotide sequence ID" value="XM_022015018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULY5"/>
    <dbReference type="GeneID" id="33556826"/>
    <dbReference type="InParanoid" id="A0A1Y1ULY5"/>
    <dbReference type="OrthoDB" id="3361009at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="152" mass="15609" checksum="E712AE60901BD7BD" modified="2017-08-30" version="1">MSTQPIVSPTGITQSGSHTTSTTSHNAPGLDRDHPSLPPVAGSEADSSAATAGVQGVAPPSQVADTVYPNVPETSEPQQGATGPGQGSVVNHEHHGDKPSFKDQVNGFAKKIAGKVFHNEEEVQQGRELHGEPPSGQESVKPHTGLAANTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM04</accession>
    <name>A0A1Y1UM04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_649546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872087.1">
        <property type="nucleotide sequence ID" value="XM_022018009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM04"/>
    <dbReference type="GeneID" id="33559818"/>
    <dbReference type="InParanoid" id="A0A1Y1UM04"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="544" mass="60729" checksum="D7946BA752EEA27E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM22</accession>
    <name>A0A1Y1UM22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_618491</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872956.1">
        <property type="nucleotide sequence ID" value="XM_022015033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM22"/>
    <dbReference type="FunCoup" id="A0A1Y1UM22">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM22"/>
    <dbReference type="GeneID" id="33556841"/>
    <dbReference type="InParanoid" id="A0A1Y1UM22"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="157"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="19">
        <location>
            <begin position="307"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="654"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX39093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="795" mass="87641" checksum="2CB4624831EE130D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM66</accession>
    <name>A0A1Y1UM66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_587988</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873011.1">
        <property type="nucleotide sequence ID" value="XM_022013761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM66"/>
    <dbReference type="FunCoup" id="A0A1Y1UM66">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM66"/>
    <dbReference type="GeneID" id="33555569"/>
    <dbReference type="InParanoid" id="A0A1Y1UM66"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX39148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="429" mass="48749" checksum="5E134EA313566366" modified="2017-08-30" version="1">MPYSTSPDDSLRHRHTSKSNNSSLDPSPAGTDDEAPPPSTLSENGDAKGDYLSVDESKREKKSSGRRSALAEARRKMKRMQSPLLESLDDLRENISKGVEIQFAPLNIPPHRRLQTAAVAFWALLLPFCLFVFLLLMSLPPTWVVLIPYLIWTRFDKAPEWGGRPREWARRSFIWKYFAEYYPCSIVKEGDLPPDRPYLFGYHPHGIIGMGALATFATEGSHFSEKFPGIQPHLLTLESNFMMPFYRDLIMSLGIASVSKQSCKNILSRGPGHAIAIVVGGATESLSAHPGTADLTLRRRFGFIKIAIREGADLVPVFGFGENDIYDQLPNDKDTVVYKIQKNFQKVFGFTLPLFYGRGIFNYNYGLMPFRHPIVTVVGTPIRVEKNLNPTDEEVQQMQKVYIDQLMRIWDKYKDVYARHRTKELTLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMI4</accession>
    <name>A0A1Y1UMI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_622115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872649.1">
        <property type="nucleotide sequence ID" value="XM_022015438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMI4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMI4"/>
    <dbReference type="GeneID" id="33557247"/>
    <dbReference type="InParanoid" id="A0A1Y1UMI4"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011830348" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="189"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="511" mass="56497" checksum="7FE66AD57D9F533B" modified="2017-08-30" version="1">MLSILAIAAVAGSVRAAPWTNEHGLIERDQTSASSWSNQWQPDANGVVHYGFNATFNQGYWNASQIRTAYRGCNGMSVSWSTNGRNVVPTVLYGTSNSSLNWTATSSVSITYETSLKWENHVVLENLEPNTKYYYSVCGSPVNSFTTARCAGDMTPYTAAVVVDMGAMGEYGLRHNLPSDISNPIPANQTNTIQRLVAQMDDYEFVVHPGDMAYADYWVKEQVTHGSNLTLTDQVLGYNAINDAFFNEVAEVASKKAYMVGVGNHEANCINGGYKQYPEAICTAGLTNFTEYKVRWNMPGDGSASNNFWYSFDVGMAHYLIFDTETDLPPPYYGADVIGGVAGMYESNVGAYPTAQVDFIKQDLASVNRTQTPWVIAMGHRPWYVSAAPEDRFMSGLAVFEPLFEAANVDVVMQGHVHLISRSYPVHQNGTVQQYNYTEPQAPVYLVNGAAGHYDGLDKEYTPLYDYIAFANDTMYSYSKLTFHNSTHLTHQFMASGDNSVIDAITIEKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMK9</accession>
    <name>A0A1Y1UMK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP synthase subunit D-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_641743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872646.1">
        <property type="nucleotide sequence ID" value="XM_022017442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMK9"/>
    <dbReference type="FunCoup" id="A0A1Y1UMK9">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMK9"/>
    <dbReference type="GeneID" id="33559251"/>
    <dbReference type="InParanoid" id="A0A1Y1UMK9"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000008">
        <property type="entry name" value="V-type H+-transporting ATPase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="263" mass="29214" checksum="0F268680CDE9F13D" modified="2017-08-30" version="1">MSGTGPREAVFPTRMNLTLTKGRLKGAQTGHSLLAKKRDALTTRFRQILKKVDEAKRLMGRVLQLASFSLAEVTYTAGDIGYQVQESVKRASYTVEARQENVSGVVLPTFESVRSKEGNDFNLTGLSRGGQQIQKCRDTYVKAVGTLVELASLQTAFTILDEVIRATNRRVNAIEHVIIPRLDNTIKYINSELDEMDREEFFRLKKVQGKKKRDAERVLNERKEKNDAHEQSGGSVHRDEGIGGGAGGGDDMLGQGKDEDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMR8</accession>
    <name>A0A1Y1UMR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_619339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873211.1">
        <property type="nucleotide sequence ID" value="XM_022015163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMR8"/>
    <dbReference type="GeneID" id="33556971"/>
    <dbReference type="InParanoid" id="A0A1Y1UMR8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="762" mass="83625" checksum="A3F1041A88152790" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMU0</accession>
    <name>A0A1Y1UMU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_577093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873236.1">
        <property type="nucleotide sequence ID" value="XM_022013238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMU0"/>
    <dbReference type="FunCoup" id="A0A1Y1UMU0">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMU0"/>
    <dbReference type="GeneID" id="33555046"/>
    <dbReference type="InParanoid" id="A0A1Y1UMU0"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="157"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="392"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="515" mass="56771" checksum="515880328016E44C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNC4</accession>
    <name>A0A1Y1UNC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_576087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873345.1">
        <property type="nucleotide sequence ID" value="XM_022013172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNC4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNC4"/>
    <dbReference type="GeneID" id="33554980"/>
    <dbReference type="InParanoid" id="A0A1Y1UNC4"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="10">
        <location>
            <begin position="346"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="563" mass="63611" checksum="84C2E83928EF599A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNM5</accession>
    <name>A0A1Y1UNM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_618494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872957.1">
        <property type="nucleotide sequence ID" value="XM_022015034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNM5"/>
    <dbReference type="FunCoup" id="A0A1Y1UNM5">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNM5"/>
    <dbReference type="GeneID" id="33556842"/>
    <dbReference type="InParanoid" id="A0A1Y1UNM5"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="38734" checksum="F69ADBB6FAF0F97A" modified="2017-08-30" version="1">MATDIPNQMKALRIHGVGEKYYKLEQVDVPSPKGYEALIKVGAAGLCHTDMMLFTGEFKTDKYPLIGSHEPAGTVVALGEDAKGTVKIGQRVAGMLHRDVCGECTDCKAGLPKYCPNSLYTGITTNGAFAEYEILDARYLAPIPDEMSFEQAAPMTCAGITIYTAIKKAKLKPGQILAISGLGALGHLGVQMAKAMGLTVVGIDARPEPIAMTEGLRLAPDLCIDATSLKAEEAVEEIHKLRPKGYEGWKGADATILTSDPLSAQRYAMDITRRHGTYVVVSQPDDLRFTYQDIIFKDLTIIGSLHGWTEDLKECLDLAAKHGIKSELSCYKLDKHEEMVDSVHDSKRKGKSVLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP69</accession>
    <name>A0A1Y1UP69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_615205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873625.1">
        <property type="nucleotide sequence ID" value="XM_022014692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP69"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP69"/>
    <dbReference type="GeneID" id="33556500"/>
    <dbReference type="InParanoid" id="A0A1Y1UP69"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="525" mass="58534" checksum="6CF22F2FA981EEE5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPC2</accession>
    <name>A0A1Y1UPC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative tRNA adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_615441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873685.1">
        <property type="nucleotide sequence ID" value="XM_022014720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPC2"/>
    <dbReference type="FunCoup" id="A0A1Y1UPC2">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPC2"/>
    <dbReference type="GeneID" id="33556528"/>
    <dbReference type="InParanoid" id="A0A1Y1UPC2"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="5">
        <location>
            <begin position="56"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="506" mass="57009" checksum="E59DEAA30A5FBAC7" modified="2017-08-30" version="1">MALRRGLHKISFNRPLSIMTSSVTHADSAIELDPKESLFVKHLDEFSQSLKPVVECRIAGGWVRDKLLRLPSSDLDVALSTASGYQFALNFVEHLRARDISTGTVGKVAANPEQSKHLETGTTRIMDLECDFVGLRSETYADSRIPTEVRLGTPLEDAQRRDLTINALFYNVHTRQVEDWTGYGLADLRNRIARTPLPPRQTFVDDPLRVVRCVRFASRFDLVIEDEVMRAIDRDDIKVELRSKVSKERIGSETLKIMQKTPLRGLTLIDRLNLHSSIFTCAVDPPRSDALTAGMVLSAVLPRLKVEPDEILWLAAALYPFRDLVVQGKKPTPAVASVIGEGLKLSNETRDGVTKLFIGAKIVADSLDATSRSTLGLTLRHPSVQPLWHRTLCWSAVMAVMEEWSGAWDDKSDGILTRFLAFEDRVRELDLEPEIGRRPLLDGKRIQEVLSLKPGPILQIITENVVAWQLDHPGSTQTECEEWLRESWEGRKRVEWEATATVKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPK8</accession>
    <name>A0A1Y1UPK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873687.1">
        <property type="nucleotide sequence ID" value="XM_022014722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPK8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPK8"/>
    <dbReference type="GeneID" id="33556530"/>
    <dbReference type="InParanoid" id="A0A1Y1UPK8"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="69" mass="7712" checksum="D6146E8AF8D088E5" modified="2017-08-30" version="1">MASSPNYYDILGVSSNASREEIRRAYLQQALRVHPDRLKEPIANTAFQMLQGGSQGPSHLMVRGVRMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPM8</accession>
    <name>A0A1Y1UPM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_615795</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873766.1">
        <property type="nucleotide sequence ID" value="XM_022014759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPM8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPM8"/>
    <dbReference type="GeneID" id="33556567"/>
    <dbReference type="InParanoid" id="A0A1Y1UPM8"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="66"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="507" mass="54278" checksum="66E6AFAB181C2605" modified="2017-08-30" version="1">MSRDALSTSASAATLTSLPDRPSERTPLVGSDSKRSRGVSWENDSQDDGDASDRGREVEVYVPGDSSFSQTVLNCLGDLIGQGILACPLAFAYSGWVFGPVMLIGFGGITLYTLKLLLRVIEKDRRLRSYTDVIGYCLGSKGQAIVSVLFALDCMIWLIALLIVFADSFHVLVPSISSTQWKLLSLILTIPLSYLPLRYISLASFLGVTGTWSLVGILVFSGATTPHGPGSLRDPAHTDILPAHGVIKLGTAIGLFISGFGGHSLVPTLIHDMKNPKRADHMCHLAYAICLVVYVLVAVVGYLMYGANVSDQVTKDLVKAPGFSPLLNQFAVLATAVNAVTKLPLGFRPLADMSFTMLGLHPTILIPRVAPTPRYTEPSTPTVEGSEDSPFMNSDGLNSGISLHAPLPIIDDHGQHNHRERLKLIARTLIQFALPVLPVIAAIVLPSFESLLSFLGSGFAVVISILLPIAAKASVYGWRKHEVAVFAFSAIAGTIGVICTFAPDKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQI1</accession>
    <name>A0A1Y1UQI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_617230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874086.1">
        <property type="nucleotide sequence ID" value="XM_022014901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQI1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQI1"/>
    <dbReference type="GeneID" id="33556709"/>
    <dbReference type="InParanoid" id="A0A1Y1UQI1"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF33">
        <property type="entry name" value="HELP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="576" mass="63689" checksum="ADFF13A0AC988507" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR27</accession>
    <name>A0A1Y1UR27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_596040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874189.1">
        <property type="nucleotide sequence ID" value="XM_022013854.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UR27">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR27"/>
    <dbReference type="GeneID" id="33555662"/>
    <dbReference type="InParanoid" id="A0A1Y1UR27"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000009">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase HECTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="2935"/>
            <end position="3270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1088"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1775"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2206"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2610"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="2164"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1102"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1786"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1821"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1891"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="3238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="3270" mass="360300" checksum="52990F52E8D8ED06" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR39</accession>
    <name>A0A1Y1UR39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_648571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873739.1">
        <property type="nucleotide sequence ID" value="XM_022017857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR39"/>
    <dbReference type="FunCoup" id="A0A1Y1UR39">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR39"/>
    <dbReference type="GeneID" id="33559666"/>
    <dbReference type="InParanoid" id="A0A1Y1UR39"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="109"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="481" mass="53347" checksum="4CA14D595C460D8B" modified="2017-08-30" version="1">MSSGESSSSRIDYSRLLSWEAKHRARSGIKMLRPYMSIPGMISFGGGYPHASTWPVNGMTLSLPFSGESVFVPGYQTNSPDGLLPLASYSPPPKTSTLQPHLAAELQYSQTFGQVHFISWLKEHIARIHNPPYAKYEDYTILNTAGNTDGVDAVLRTCMDKGDHVLVEEFAYPGTLSHCESLGLPAIGVPMDSDGIVPSALEDMMSRWDENERGGKRPKFLLVVPTCSNPAGATIPAERKREIYTICRKWGLMIIEDDPYYFLQIRPNGVDSPPCTSFLSMDIDGRVIRLDSFSKIVAPGSRCGFITGPTELVTHIMYSRECSTQLPSGFSIAIISSILQAWGGHEGYEKNYLPYISSVYSKRAILMSNLISKHVPAKAATAPPPSGGMFLWLRLHLEDHPDISDTSVSLEDLAERVFQSLIEAKVLTVPSKFFKAPGKSWTRDEEAKRIFLRLSFATATEEEITEGVQRIGRALTKEWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR79</accession>
    <name>A0A1Y1UR79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_611331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874252.1">
        <property type="nucleotide sequence ID" value="XM_022014259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR79"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR79"/>
    <dbReference type="GeneID" id="33556067"/>
    <dbReference type="InParanoid" id="A0A1Y1UR79"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33452" checksum="9582760F6C0FB29D" modified="2017-08-30" version="1">MMNVLSAQDKQRWRQDGYLVLPGFFEQAATEEMLGRARQLLDEFDVEGHPLTTFKTEADGEHVGDDYFIGSNDKIRYFLEPSSLSKPAPGAPSKLLVPPAQSINKIGHALAQLDPVFRKYTLENEKVANVAKDLGYHQSPRVLQSMIICKQPRIGGVVPSHNDSTFLYTDPPSAVGCWIALEECTPQNGCLSFLPGSHKTARVSSRFVKDPSGRGTTFESVAGVEPNEEKWDELDGWVEAACPAGTLVLIHGNVMHRSPPNPSDKSRLIYTFHMIEGAEGYTYDEKNWLQPTKDMPFPALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR98</accession>
    <name>A0A1Y1UR98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalose utilization-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_611310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874249.1">
        <property type="nucleotide sequence ID" value="XM_022014258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR98"/>
    <dbReference type="GeneID" id="33556066"/>
    <dbReference type="InParanoid" id="A0A1Y1UR98"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012485829" evidence="2">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ThuA-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="333" mass="35355" checksum="978869BA7E897D5F" modified="2017-08-30" version="1">MLPVLAFIYLAAFIMSTSAQSTPHILVYTATKGYRHESIPAAIDVLGQQADRWNVSFTFTEDPSMFTTDTLSQFDGVMFALNSGEVLDDDGQAALQTFFQSGGVYTGVHSGSACLYNDTNYAQAVGALFDYHPELQSATFERLNDTHPATKNLPDRFTWEEEVYNFRSDPRSNDAVILLTVDENSYQHGGSSTGDYPDQGTPHPIAWYIESPKSALPLQADAPRAGRSFYTSLGHLNTTWQNDTFIDHLMGGLTWALEGRSTRAYGVGLVGNSSAEEDGKSTPSGTTSASVSESSGAAATSGAAGQSRVGSSNMGLTAAAVAGAIGAGIALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URM8</accession>
    <name>A0A1Y1URM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_611429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874271.1">
        <property type="nucleotide sequence ID" value="XM_022014266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URM8"/>
    <dbReference type="STRING" id="4999.A0A1Y1URM8"/>
    <dbReference type="GeneID" id="33556074"/>
    <dbReference type="InParanoid" id="A0A1Y1URM8"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX40592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="21734" checksum="279E2203638499E3" modified="2017-08-30" version="1">MNLQRSLQRIIQQTSRPLVKPSIATTPFRMSSTATDVGTYKFNHTMFRIKDPKVSIPWYEKVLGMELINESPGGDFTNYFLAYPSGQSDKVKSQEDKKKFQAEREGVLELCHNWGTESDSEFKGYANGNSEPGRGFGHICVAVDNLEAACKRFDELGVNFKKRPEEGKMRHIAFILDPDGYWVEIIAFKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URT5</accession>
    <name>A0A1Y1URT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_640556</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874331.1">
        <property type="nucleotide sequence ID" value="XM_022017356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URT5"/>
    <dbReference type="FunCoup" id="A0A1Y1URT5">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URT5"/>
    <dbReference type="GeneID" id="33559165"/>
    <dbReference type="InParanoid" id="A0A1Y1URT5"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="427"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="252"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="486"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX40652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="653" mass="74087" checksum="030F76B9614FED89" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URW1</accession>
    <name>A0A1Y1URW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_616669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873961.1">
        <property type="nucleotide sequence ID" value="XM_022014845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URW1"/>
    <dbReference type="FunCoup" id="A0A1Y1URW1">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URW1"/>
    <dbReference type="GeneID" id="33556653"/>
    <dbReference type="InParanoid" id="A0A1Y1URW1"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="210"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="337" mass="38526" checksum="029DD482EE258573" modified="2017-08-30" version="1">MANAVASSSRTRRQNEPSQRSPRPNGETESDEEESERQAKPRILVEAGWTNATFVNRPIVKSTALINKIIKLQADLTQVIVEINEGLERARDLAREIEECSEDDDMIKSIEKNFLRNLEQRQLIQIQHDVLGEMSLKLRANEELVDADSYYENRCAELSAQYEAKTARAKFKESEDYQSFRALIWEINHEEGGPPITFYLPKEDGDESDEDFEMGSMVQTYRCPITLLPFKEAVTRFVVTWHCSYRRSTLSPPLSVTCKHSFSRQAILEMFDQQRARAAASTINCPVSGCKEKLARHDLKDDPRLQKLCDAAEKRKALYGHDDGDDSEAELIDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URY7</accession>
    <name>A0A1Y1URY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874049.1">
        <property type="nucleotide sequence ID" value="XM_022014883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URY7"/>
    <dbReference type="FunCoup" id="A0A1Y1URY7">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URY7"/>
    <dbReference type="GeneID" id="33556691"/>
    <dbReference type="InParanoid" id="A0A1Y1URY7"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="277" mass="30176" checksum="2D4A0E12770D1F4E" modified="2017-08-30" version="1">MSRSYDRALTVFSPDGHLFQVDYAMEAVKRGTCAVGVRGEHCAVLGVEKKSALQLQDPRTVRKVAMLDDHVCIAFAGLTADGRILIDKARVECQSYRLTVEDPVSIEYITKHVAGIQQKYTQSGGVRPFGISTLIIGFDPNDDKPRLYTTDPGGIYSAWKACAIGRASKTVREFLEKNYTEKLSNDEAIKLTIKSLLEVVQTGAKNIEISVMESFGVVRNLEQSEIEKIVAGIEAEKEAEAERKRQRIAQTQAGQSGMAMSLGTSTPTVQGGGGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US01</accession>
    <name>A0A1Y1US01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_611918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874421.1">
        <property type="nucleotide sequence ID" value="XM_022014326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US01"/>
    <dbReference type="FunCoup" id="A0A1Y1US01">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US01"/>
    <dbReference type="GeneID" id="33556134"/>
    <dbReference type="InParanoid" id="A0A1Y1US01"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="159"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="397"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="640" mass="71418" checksum="2151F284BE5A1034" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USQ8</accession>
    <name>A0A1Y1USQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GTPase activation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_575172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874728.1">
        <property type="nucleotide sequence ID" value="XM_022013112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USQ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1USQ8"/>
    <dbReference type="GeneID" id="33554920"/>
    <dbReference type="InParanoid" id="A0A1Y1USQ8"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="353"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="584"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX41049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="87114" checksum="2BBB384F8DEAAC3F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USS3</accession>
    <name>A0A1Y1USS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_586233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874747.1">
        <property type="nucleotide sequence ID" value="XM_022013743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USS3"/>
    <dbReference type="FunCoup" id="A0A1Y1USS3">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USS3"/>
    <dbReference type="GeneID" id="33555551"/>
    <dbReference type="InParanoid" id="A0A1Y1USS3"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="442"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX41068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="512" mass="55366" checksum="C8F2155A77AAF17B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT21</accession>
    <name>A0A1Y1UT21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_606460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874255.1">
        <property type="nucleotide sequence ID" value="XM_022014017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT21"/>
    <dbReference type="FunCoup" id="A0A1Y1UT21">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT21"/>
    <dbReference type="GeneID" id="33555825"/>
    <dbReference type="InParanoid" id="A0A1Y1UT21"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012734006" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="766" mass="85277" checksum="AA8BB10E62DD541B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT93</accession>
    <name>A0A1Y1UT93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_51549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874910.1">
        <property type="nucleotide sequence ID" value="XM_022012975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT93"/>
    <dbReference type="GeneID" id="33554783"/>
    <dbReference type="InParanoid" id="A0A1Y1UT93"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="34984" checksum="0419F9295F00EF38" modified="2017-08-30" version="1">MDHVLRELSDIFVTVNVSMIGLGKHVSTYLEHNRQVTVSAMKDKTKKEALGGIKIDSFTPFFPAALGTNENDALFKLSEQRSKDDVKLDIAVIQCSFWDDVHRNLSGIFADLERHFEADPTAWGYRPITADVDYYEPIPDHPSRFQLYFLGASKPPFESKWKEVVGVRQNLKYSLFYGALNAADIVLPSFGTARYDISRASSTMGVAASASVSPQLAGSALQVNCSKADHLPFGPRQAPLLVPQSYIDAYGYLCPAFGVLRKDGLSEIDYVAEVRRGAIPWESRRSREEALSRCQEDWTAKNMYVLSRLFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTB3</accession>
    <name>A0A1Y1UTB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_574835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874939.1">
        <property type="nucleotide sequence ID" value="XM_022013091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTB3"/>
    <dbReference type="FunCoup" id="A0A1Y1UTB3">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTB3"/>
    <dbReference type="GeneID" id="33554899"/>
    <dbReference type="InParanoid" id="A0A1Y1UTB3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="306" mass="34602" checksum="D25907AEC7759F90" modified="2017-08-30" version="1">MPWPHFTLNDGSSMPSIAYGHIYWVNQETIEPDVIKAIETDFIHLDTAQGYYDEDRFARAIKKSNKSRKDLYITTKWSRADTDIKDACENSLRQLEVDQVDLYLIHNRGLCGNDIEGHWARMELVKKLGYTKSIGVSNFNLHDLKTLIASCSIVPAVNQIQLDPHFYAEQIPLIEYCREKGIVVEAYSALIPLREDPDGPISKTLQRIGKDKNAEPEQVLMAWCLAKGCAVVTSSHQESRMKSYIQAGDVKLSSEDIEAIDKAGKQAAFRANTMKLARATSRRFISALGVFAVCWLLSLMIRVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTD1</accession>
    <name>A0A1Y1UTD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_648148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874950.1">
        <property type="nucleotide sequence ID" value="XM_022017792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTD1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTD1"/>
    <dbReference type="GeneID" id="33559601"/>
    <dbReference type="InParanoid" id="A0A1Y1UTD1"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="91"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="476" mass="53324" checksum="629830B6EAA1FC03" modified="2017-08-30" version="1">MTLDPSPPSDELFLPFVTTVRRDHPSLGIPKLLALLKTQQPEWSVSEKRLRKAVQSLTLDEQGRESMDEPGLVATTGLDPSITSLAASTAPKVKVRMFGGEKGKGLVARERIHKGEVVWQEEPWIVTSSPQLYSALLGKQMCSHCFFLFSRPSPPMSAPCPHCDQAVFCNRLCASKASSSSHPDLLCPGLNPAAQPLWKLIRDTNGRYLETAAKIVAKWRWERELGDKGKAKEIEQRVWNGMARVSMEEREKEKKEWKLFAELKRGEWKHAHSLLLQALNPSEGDKSYKVVQKLLTKASKRSPIPLSEGEIQRWFSMDSFLELLGLAALNSEDSGGLYALHAHLNHACEPNIAALNLSKAFVPPSSSELPCEVPDPSQSGPRGTNKLTLLARRTINPGEELTIPYVNFNMPRGDRRQMLRESYGFWCDCPKCKREEGKEREGDDLATSSKESTREMIDKMKSMQMFQGTGEKVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTG8</accession>
    <name>A0A1Y1UTG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_612175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874493.1">
        <property type="nucleotide sequence ID" value="XM_022014363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTG8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTG8"/>
    <dbReference type="GeneID" id="33556171"/>
    <dbReference type="InParanoid" id="A0A1Y1UTG8"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="391" mass="43549" checksum="0CDC735E4D9CA4B8" modified="2017-08-30" version="1">MSKTAAPRKTHRVGIIMNGVTGRMGTNQHLIRSILAIQKQGGVTCADGDKIYPEPVLVGRNIDKLHDLAIANGVDKSCCTTDEDAALADPKNMIYFDAQTTGRRADAVKKAIAAGKHVYCEKPTATTTKGAYELYKIAKDAGVKQGVVQDKLFLPGLVKLKQLIDGGFFGEILSVKGDFGYWVFTGLTPVAPQRPSWNYRKEDDGGIIVDMLCHWRYVIHNLFGPIKSLTCLGATHIKERVDESGQKYKCTADDASYATFELESGVIVNFVSSWTTRPRRDDLLTIQVDGTQGSAVATLRDCVIQHESSTPRPIWNPDVPATIDHYATWSKMPDYQVCDNAFKVQWEMFLRHVIKDEPWKYDLLEGAKGVQLTELGLQSWAERRWVDVPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTH8</accession>
    <name>A0A1Y1UTH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_22978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874503.1">
        <property type="nucleotide sequence ID" value="XM_022012230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTH8"/>
    <dbReference type="GeneID" id="33554038"/>
    <dbReference type="InParanoid" id="A0A1Y1UTH8"/>
    <dbReference type="OrthoDB" id="3594971at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="280" mass="31256" checksum="46099AB73713662C" modified="2017-08-30" version="1">MTLQYARRSSIIDPMSNAMSIQSTVDGLSGAQAPNTHGILANSTEAIQRLITRFPYASSPQALTKPGPLLPLEVLNMSIYHVRGDGHRDALASLRLVSKAFEKIATPIFFEDLTLTRRNFFDAMPLATTSKERSHEHAEQRKARLMGYVKRLTVKSLPVGSSLRAWSQSQVLAPKNSVIFKSIDSLNFQCVPWTMKKPCGVKWFAGQIHHFFPEDQLRLVTLGFVGKMDDVFDIKVTDTLFTRLSPVVRQCTIEYLLPAGRMPHVVPGAPRHVLSLRSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTH9</accession>
    <name>A0A1Y1UTH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_53271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874941.1">
        <property type="nucleotide sequence ID" value="XM_022013007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTH9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTH9"/>
    <dbReference type="GeneID" id="33554815"/>
    <dbReference type="InParanoid" id="A0A1Y1UTH9"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="499" mass="55883" checksum="F0E2ACB6B99E4B5D" modified="2017-08-30" version="1">MEDRTALLFPSTRPTPHSTPLSIIDSSVASYSPCSALWLFGKSDEGWSASALQESLRRTLDVYPQFSGKLYIPQYDAEAAVRDHTRRFGRIHIAWGNKDDPGLQFTFASSSKSAQEYIPLMSGQRTPLRTPWDLFPDLQSIPNPRREVKPCVLIKVTLFADGSLAVGIALHHSLSDIQTLCTFVRDWGAAHRNLTLTQRPFNPLAVDDHAPYLDEMQESPTLRDRALKIPQIRLDYWAGGPSRAIKSATAPHEAIDHLDEAQGRPRGTPIPWDTWDSKAPVSDAYIHFSREQLELLWTRASAGRRVSRLDALLAHLWRLVVKARQLQDEEIVHFDMSIGLRSRLYPPLGDTFLGSPLINISSSVGAAELIDRPLSDTAALIRHTVEKADSDSLNALLHHLAFALDPEREWNAFLGKHHCMVTSWLSTGSWNIDFGAGRPLEVYSGISALDGLMVIMDEPCDLFDASRRWYEDGVRIRMCLATNVMDKFLADPEFSGTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUL9</accession>
    <name>A0A1Y1UUL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA recombination and repair protein Rad51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_26895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874574.1">
        <property type="nucleotide sequence ID" value="XM_022012334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUL9"/>
    <dbReference type="FunCoup" id="A0A1Y1UUL9">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUL9"/>
    <dbReference type="GeneID" id="33554142"/>
    <dbReference type="InParanoid" id="A0A1Y1UUL9"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="229" mass="25244" checksum="1B5D4093F1E78920" modified="2017-08-30" version="1">MLGGGISTQSITEVYGEFRTGKTQLCHTLCVIAQLPDDQGGASGRVAYIDTEGTFRPDRIRDIAERFGVDSDMVKDNILCGRAWSSEQQCEMLVDLAVRFVEDRTYKLLIVDSVMNLFRQDYSGRGELSERQQRLNQFLARLQKLAEEFNIAVVLTNQVQADPGAAAMFAAASSAKPVGGHILAHASATRIQLRKGRGEERIAKLNDSPDMPEAEATYTLKSGGWEDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5R6</accession>
    <name>A0A1Y1U5R6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867717.1">
        <property type="nucleotide sequence ID" value="XM_022017295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5R6"/>
    <dbReference type="GeneID" id="33559104"/>
    <dbReference type="InParanoid" id="A0A1Y1U5R6"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="241" mass="27206" checksum="224199C068C27FC2" modified="2017-08-30" version="1">MDQVKVLLFDCFGTLIDWERGMYENIGPLLEQKTCPTVEEVITSLVNEQTPIQNADKTMPYPIVLQESYRQLIAKFRLHYDQDDAEALGDSVTSWPVFSDTGDCLARLRDLGLKLVILTNVDGDSFDQLQQTLEECSGIKFDAIYTADEIGSHKPDLRNFDYALNDLSESFNVSRGQVLCVAQNKLIDIEPANKIGIRCARINRPGVLTGHRGSIDYTKADFEFASLEEFTEEMERVHDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5Z4</accession>
    <name>A0A1Y1U5Z4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="16">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_639692</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="16"/>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867747.1">
        <property type="nucleotide sequence ID" value="XM_022017269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5Z4"/>
    <dbReference type="FunCoup" id="A0A1Y1U5Z4">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5Z4"/>
    <dbReference type="GeneID" id="33559078"/>
    <dbReference type="InParanoid" id="A0A1Y1U5Z4"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000005">
        <property type="entry name" value="crossover junction endonuclease MUS81 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="18">
        <location>
            <begin position="516"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="378"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="831" mass="92099" checksum="617633FC4B85B6A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6W0</accession>
    <name>A0A1Y1U6W0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bola protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_683928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868031.1">
        <property type="nucleotide sequence ID" value="XM_022019202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6W0"/>
    <dbReference type="FunCoup" id="A0A1Y1U6W0">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6W0"/>
    <dbReference type="GeneID" id="33561011"/>
    <dbReference type="InParanoid" id="A0A1Y1U6W0"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="138" mass="15002" checksum="CE77AAAB2A858A14" modified="2017-08-30" version="1">MMSISKSRLIARAWIARPTSSSSRQIYLAAPSASSSSASRPTIGSRAFSDTSSRRAGALSGEHVEKRMEEKLRKEFNPTRLGIQDTSGGCGSFFNIDIESEKFVGMTKVKQHKAVQNAIKEEIEGMHGVSLRTSPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U755</accession>
    <name>A0A1Y1U755_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868158.1">
        <property type="nucleotide sequence ID" value="XM_022018722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U755"/>
    <dbReference type="GeneID" id="33560531"/>
    <dbReference type="InParanoid" id="A0A1Y1U755"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="387" mass="43054" checksum="A65947DF8CA9EAE4" modified="2017-08-30" version="1">MQSSEGTSEQGQGGLSQRPMNTDKDPRGSTSKSVTWGNDEDTSDYETVVDRLKSKLREYNDALDWQFSGLPVDVEEATAILSLWGEANEPPEAEDLTFLSDPSQIQWPKPSKKGKETIESVEAATERAESYQLLADFYAETSSQISDMKADDTEPPSPKRLRTLAPGITSDDTLANQIQCAEAYMSQDSYPWVGPSESAFANLQHHCIQFDKQLQASGATNVHDFCNSDQGTAIMNEIHSAQHSLKDPSFKHLDPILWSIYFVATTQFDHENIRTFEDAVSQAAPTARWDLFFIKCQDINKTASDAEADGYHVDLSQRCKSASEVSRLCDWYLGGKKVDTEFARSVAKKLIRDEPPSPEFLAALGDRDDDSLARPLYSAFLEHLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8C8</accession>
    <name>A0A1Y1U8C8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_583724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868551.1">
        <property type="nucleotide sequence ID" value="XM_022013635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8C8"/>
    <dbReference type="FunCoup" id="A0A1Y1U8C8">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8C8"/>
    <dbReference type="GeneID" id="33555443"/>
    <dbReference type="InParanoid" id="A0A1Y1U8C8"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="10">
        <location>
            <begin position="163"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="9">
        <location>
            <begin position="335"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="490" mass="53964" checksum="769E05F1D6F700F8" modified="2017-08-30" version="1">MAAPRAASSRLFTTSVRLSYYSHRGLRSSYPPRRENGDHPGHSGQSPYSIRYSSSTTGEDGPLRPDASTDPKSSSSSSSSSPPPVGSDRRYQKTSSSFSSRPPYQTRSKPFYNPRPTTGSPYNPDVSSTSRPFPQPPVRPLQRAPVKHTPHGRFKRQGPPPSLLTLADLSPGQISRAISHALAIKYVATRLHPRDLPAVLEKQTIALIFSKRSTRTRVASETAAHLLGANAMFLGKEDAQLGVNETLRDTANVVGSMTEGFMARVNAHEEVVELAKHSPVPVINALCDLYHPTQILADLMTLQEAYAPQPLKTKSTSFDAIRTAIRAMKPLECLKGKKMAYVGDTNNISNELLVTVPRLGMEFAIASPEGYNKVDPRVWERVVNAGTENKVTLTTDPMVAIKDADVIVTDTWISMGQESESAARLEAFKGYQVTNELISKAGAKPDWKFMHCLPRHQEEVDDEVFYGNRSLVFPEAENRKWTTAACFGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8H1</accession>
    <name>A0A1Y1U8H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_179207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868590.1">
        <property type="nucleotide sequence ID" value="XM_022012109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8H1"/>
    <dbReference type="GeneID" id="33553917"/>
    <dbReference type="InParanoid" id="A0A1Y1U8H1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="274" mass="28397" checksum="83EAE4324DF573D5" modified="2017-08-30" version="1">MSLSIQPNFLHSFIHIYSSTMLFSIAFAATLSLASATPLKRWGGGSQDTGCLINGISILDCTNINVSDILNGLTADLLKRDPCPTCDGGSGQSSACEVNGISLLDCSNLNVGDLLNDLGLDILKRNPCPTCGGNEPPSQSSACVINGISILDCTNLGSQDTGCLINGISIADCSNINVQDILNDGFASILRRGWGGHSPSQDTACLINGISVGDCTNINVSDILNDGVASILKRDGLRPKPRSSTGCVVNGVSVLDCTNLNVGDILNGLIVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8H8</accession>
    <name>A0A1Y1U8H8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_638621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868096.1">
        <property type="nucleotide sequence ID" value="XM_022017139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8H8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8H8"/>
    <dbReference type="GeneID" id="33558948"/>
    <dbReference type="InParanoid" id="A0A1Y1U8H8"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="177"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="619" mass="67079" checksum="D91FEBFFBA19001C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8K3</accession>
    <name>A0A1Y1U8K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_583367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868605.1">
        <property type="nucleotide sequence ID" value="XM_022013618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8K3"/>
    <dbReference type="FunCoup" id="A0A1Y1U8K3">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8K3"/>
    <dbReference type="GeneID" id="33555426"/>
    <dbReference type="InParanoid" id="A0A1Y1U8K3"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="351" mass="38859" checksum="A0D602BD725541F5" modified="2017-08-30" version="1">MKTPIPVIKTLSELRHWRQAARMANNDVAIVPTMGALHQGHLDLVRHALNRHALTVMTLFVNPMQFAPTEDLSKYPRTLEQDLALLAEVVTKHASTRSTITGTQLTSTDAPFRAAAYEIASAQSPLIVFNPHQYEMYPLRGELQDMNKHSGLRIEMRGIGNVLEGQSRPQFFTGVATVCTKLFNAVEPDHAYFGQKDIQQALLLKLMVTDLLLAHPKPSNLHILPTTRDPTSSLALSSRNAYLSPEELKVAPVLYKALTASHTLWKEKGAIVTGEQLVECSKSIISEEMAAVAASGQAVTLRLDYIELFDRDTFTIIRGPVQDWKTMVLAGAVFVGNTRLIDNVLLGWTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U942</accession>
    <name>A0A1Y1U942_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_584220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868352.1">
        <property type="nucleotide sequence ID" value="XM_022013670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U942"/>
    <dbReference type="FunCoup" id="A0A1Y1U942">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U942"/>
    <dbReference type="GeneID" id="33555478"/>
    <dbReference type="InParanoid" id="A0A1Y1U942"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="350" mass="39762" checksum="3BC0D19A8E4DFEF2" modified="2017-08-30" version="1">MEASQSSLEAGPSRPTVSAADKWVKPNGPPVGVTFGARTLGEDQDVWEHNTWDHVELPADFQTRAAEAIERQLANPVAQDKRDAYNEDPERYWNAFYANHKDQFFKDRSWLRSEFPELIECSEANAGPKVVLEVGCGAGNSIFTLMKYNENPELEVYATDYSSTAVEVVKNNPMFPCPDHGKGKIRASVWDITSEPSSTSPYGLPDGIEPGSVDVLTVIYVLSALHPSEWERAIHNLYTALKPGGLLLLRDYGRHDLTQLRIKKDRLLDPNVPNLYIRGDGTRVYYFDQDDLTRLLKRPSEDGAMQEMFEITQLGEDRRMIVNRKLKLQMFRIWMQVKARKRAEDDAPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U964</accession>
    <name>A0A1Y1U964_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868334.1">
        <property type="nucleotide sequence ID" value="XM_022017087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U964"/>
    <dbReference type="STRING" id="4999.A0A1Y1U964"/>
    <dbReference type="GeneID" id="33558896"/>
    <dbReference type="InParanoid" id="A0A1Y1U964"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="583" mass="64276" checksum="542D7D04917A8F1E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9R1</accession>
    <name>A0A1Y1U9R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_683673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868524.1">
        <property type="nucleotide sequence ID" value="XM_022019198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9R1"/>
    <dbReference type="GeneID" id="33561007"/>
    <dbReference type="InParanoid" id="A0A1Y1U9R1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="129" mass="13910" checksum="7CCBBCC4374D3FC5" modified="2017-08-30" version="1">MSAFITGNVPDHSNLSIPLYNCWSNDTRLSMACCGIAAGYYNESTKYCKEAPPNTASAQVFQYLSLEYRTCIETVMLFNSTYSSAMYACNQSVVSDTCTGAAALSITRVGYSGLVVILLLLASILCVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAB7</accession>
    <name>A0A1Y1UAB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_109543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869194.1">
        <property type="nucleotide sequence ID" value="XM_022011928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAB7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAB7"/>
    <dbReference type="GeneID" id="33553736"/>
    <dbReference type="InParanoid" id="A0A1Y1UAB7"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="492" mass="55714" checksum="BA059C18D34770D6" modified="2017-08-30" version="1">MGSQPSKPVQSTSTPITMYDEKKAATLSFQTKGDDTVGWASVPVDSLAEWSSEFDSSPTLQLSRLILTNADPVTSLTSRKALIHDNKVFNLQLKGLGAKNEYPGPRVNQGSSGRCWLFATCNVLRYNVMEQLKIEDFELAQAYLFFYDKLEKANHYLENMIELADEPNDSRTVSFLNREPLGDGGQWDMAVNILEKYGCVPKTIYPESFSSMASGKLNNMILSKLREFAIVLREQAKTQSVSSLRKTKSEMMTQIYTTLSITLGAPPHPDEPFTWDYYDSENKFHHWRGSPKEFYAQFCQRKNMAPKDSFSLINDPRNKYEHLYTVERLGNVWGGRPVRYVNAPIEALEDAVVAGIKANTPLFFGCDSGKTGDRVSGVWDTELYDTKLAYGWSLQANKTQRLETGDSSMTHAMVITAVHLDESGRPLKYKIENSWSDQNGEKGWFMMTASWFREYVYQVVIPRSVADKRWTAVYDAGNPTVLKPWDPMVSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAL3</accession>
    <name>A0A1Y1UAL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_652807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869307.1">
        <property type="nucleotide sequence ID" value="XM_022018555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAL3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAL3"/>
    <dbReference type="GeneID" id="33560364"/>
    <dbReference type="InParanoid" id="A0A1Y1UAL3"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF79">
        <property type="entry name" value="PROTEIN SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="520" mass="56564" checksum="A87DC23DEE923640" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAV2</accession>
    <name>A0A1Y1UAV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_634450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868916.1">
        <property type="nucleotide sequence ID" value="XM_022016731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAV2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAV2"/>
    <dbReference type="GeneID" id="33558540"/>
    <dbReference type="InParanoid" id="A0A1Y1UAV2"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="59"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
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        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="482" mass="51941" checksum="8F252D9828790F08" modified="2017-08-30" version="1">MRPSSRSKGTTSASTSRRPSVTRDDSSGAGPSRLEPYSEQKGRMAWGDMYAMSRGTFAGTSIRHCLELCQEPTHGRRRTDKDRRPLAHCPILRLRIYSCFKTPSGDWTESAIDLTSVECTSYVCASDLLPDRSTTPVLPTPATSSTIYAAPVAQPARAETILDTGQSTPISHGTSSSRRSSLAHLMSASAPPRGPPILPTDLDTVPGPSSLSHVPHFPSQTAPPILQNTSQGKQRERERSSGSSPNSDDPAAAKKLRGAEERNLFGSLHVSAIKVPAPDGECGVWFLFNDLTVRLEGVYQLRLRVYDLSTIAGYSGQHVQPLVEILTSPFVVHSPRAFPGVPPTTPLIEHFTSMGFKLTSRKNEKQARQQSQPKLSRKTTPERPDPHPVQPDACRHPSQRQSAMSTSSGSKTATSVSSGYRHGLSSSDLAGAGASSSRSSGVDMTDEYGVGQAGKDGNSLRPLPESSSEDVLMDAKPSQKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAY3</accession>
    <name>A0A1Y1UAY3_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868908.1">
        <property type="nucleotide sequence ID" value="XM_022018580.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UAY3"/>
    <dbReference type="GeneID" id="33560389"/>
    <dbReference type="InParanoid" id="A0A1Y1UAY3"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="700"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="65"/>
        </location>
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            <end position="403"/>
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            <end position="666"/>
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            <end position="759"/>
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            <begin position="773"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="844" mass="89233" checksum="CE39DE66264638EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBF7</accession>
    <name>A0A1Y1UBF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_635787</name>
    </gene>
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        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013390685" evidence="2">
        <location>
            <begin position="21"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="638" mass="67973" checksum="BF25A7E9C387315A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBM8</accession>
    <name>A0A1Y1UBM8_9TREE</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Kockovaella</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869153.1">
        <property type="nucleotide sequence ID" value="XM_022016612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBM8"/>
    <dbReference type="GeneID" id="33558421"/>
    <dbReference type="InParanoid" id="A0A1Y1UBM8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="172" mass="19871" checksum="7D6DB411B921ECE5" modified="2017-08-30" version="1">MPVIKFATSKSFEQLIILHLPPDPSVLRSEIIFETDFNPLVEYSDGFFAAYIAQQLKRKSHKKDFACLIVGLEYGSSFSERGRDPGISRRVEAMFKTEVLANVKPTQKVEDVKIRMDMWKFQSLREYAKELEGLDRHLLPDYVWTLLEKEDEIEGSDSESAVLRSDDELSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBT5</accession>
    <name>A0A1Y1UBT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_158919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868808.1">
        <property type="nucleotide sequence ID" value="XM_022012053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBT5"/>
    <dbReference type="GeneID" id="33553861"/>
    <dbReference type="InParanoid" id="A0A1Y1UBT5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="333" mass="34742" checksum="595F75E70F032910" modified="2017-08-30" version="1">MPSFGTSPSSAETFDSYGHNLPHHMRMTQQSSPQSRNRSVTVPMPPPLPSPGAGPAHHHLLLHGPPGQSAQSYYDQGNAGKLHGGGINRQNSSSSLASSGGAMRPSSSSQRFDPYAPASTSPRAATSGSMHSRRPSQPMIIPPGSSAGHSGSDYFPSPTYDVKPSLSPDLSHAHDLGQHTSYSYHPPATAPGSFADFGAFGSSAHQPVQSPGGAFGPSYAAWHHPSPSTAGRLNQPPPGREFGQLHHSPSHSHVSSHHSHSQSASGSQSLGVLMEAPSASSSNDGWGTPTHTHNQLPENPSGVNSFSQQVPQGWNGQYMGGDNDWRGQSTSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBW1</accession>
    <name>A0A1Y1UBW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869687.1">
        <property type="nucleotide sequence ID" value="XM_022018436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBW1"/>
    <dbReference type="GeneID" id="33560245"/>
    <dbReference type="InParanoid" id="A0A1Y1UBW1"/>
    <dbReference type="OrthoDB" id="5383572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1141" mass="124906" checksum="BD41CD802CA016D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBZ7</accession>
    <name>A0A1Y1UBZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_630642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869727.1">
        <property type="nucleotide sequence ID" value="XM_022016349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBZ7"/>
    <dbReference type="GeneID" id="33558158"/>
    <dbReference type="InParanoid" id="A0A1Y1UBZ7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="176" mass="19984" checksum="730EB9EBADE29982" modified="2017-08-30" version="1">MAKRVRQQLEWIREGRHNVCLVFGEDGRRFVQMVAEAGSHESVGFAWTAPALRPEEYGGDAPICHLLQRLAEEQFVASRDIETLLKPFPALAKAYCEHDPTRRQQVSIDMRFMYDPVIASGGTLFINVVHPQRSDEVDNPPHVVQQLDFAVSFVKSLVHGASTAPFYYQKHHDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC54</accession>
    <name>A0A1Y1UC54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869292.1">
        <property type="nucleotide sequence ID" value="XM_022018552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC54"/>
    <dbReference type="GeneID" id="33560361"/>
    <dbReference type="InParanoid" id="A0A1Y1UC54"/>
    <dbReference type="OrthoDB" id="2564290at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="420" mass="46314" checksum="1918990D8CFAC897" modified="2017-08-30" version="1">MSIAVPSTPTPQTPFIPSSSSPSLYTVTTPPESVRRYANALKAFTRVGMNAAMAELRDDNREEERQFDRRYGYDDEDPIERHVRLYLTPEKQERSLVAEIQCDVEEAQEDVEMMEDMEEVDGDQDRSRRPSLPDGPAGLARPFRPGLIHFHRSSRGSIPSLSASAPSFTRTDSSASTPFGYDDDPRVHTVDTPGSVWSEASFEAIRADDWYSLYGNSQRATMTTTREEKRYSGESDMTESYAGNRTTIGSIDTATPSSPPSSIHSGPSKRPSLLRPRPRAFPYAPLSECIRARDVDMDRSASPEPRQRKVSGPRHGADALSTSGMMTRSRQNSDTIPLSKLATPSRSRQNSGNAPVSTILARSRQDSDELKVARLAQLGLESPSTFEDDAGMGGRTISETMVFQAGLRSQRGRPGLRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCH5</accession>
    <name>A0A1Y1UCH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA2/NAM7 helicase helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_72477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869866.1">
        <property type="nucleotide sequence ID" value="XM_022019226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCH5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCH5"/>
    <dbReference type="GeneID" id="33561035"/>
    <dbReference type="InParanoid" id="A0A1Y1UCH5"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="569"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="613" mass="69420" checksum="AD33971071911CB4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCM9</accession>
    <name>A0A1Y1UCM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_652308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869933.1">
        <property type="nucleotide sequence ID" value="XM_022018470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCM9"/>
    <dbReference type="FunCoup" id="A0A1Y1UCM9">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCM9"/>
    <dbReference type="GeneID" id="33560279"/>
    <dbReference type="InParanoid" id="A0A1Y1UCM9"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1085" mass="122541" checksum="8DE9E29364F66687" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCQ5</accession>
    <name>A0A1Y1UCQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_642941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869956.1">
        <property type="nucleotide sequence ID" value="XM_022017517.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UCQ5">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCQ5"/>
    <dbReference type="GeneID" id="33559326"/>
    <dbReference type="InParanoid" id="A0A1Y1UCQ5"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="611"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="893"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="830"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1396" mass="155507" checksum="7D6158957DE0BBC9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD31</accession>
    <name>A0A1Y1UD31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_109929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869191.1">
        <property type="nucleotide sequence ID" value="XM_022011929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD31"/>
    <dbReference type="FunCoup" id="A0A1Y1UD31">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD31"/>
    <dbReference type="GeneID" id="33553737"/>
    <dbReference type="InParanoid" id="A0A1Y1UD31"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="224"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="382" mass="42212" checksum="F144221B452B3725" modified="2017-08-30" version="1">MKLDWKSNDSSRSKIISGGLMQISSAGSQLLVGTDWLSRATLLRRVDPTGMFIIDQFEVHDETGEAVILEEETMGGGGVYAMTAARMFLPPSKCALVVDQGQDFPLDFKDQLMSMGEDMFWFRECQGASTRALNMYSGRRIGDGHQSFKYLSRQAQIQLQDLVCAPSPFVNTLPDYIHLVCLLDRASAVCDELEHLRRKFPHLASWEPKIIWEPLGQACVHANLDKVASIASQFAVFSPNVLEIQSLLSIPQIVSPEAVESAAREFGNLIPDTTVIVRAGPLGSFTVSKTWSGWVPAYWKPKEQDRVIDPTGGGNAWLGGLCAGLLLSKGDIKLGCFFGSAAASFAIEQRGLPHLDKGYWNSDDPWRRLREVAARMDILTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD41</accession>
    <name>A0A1Y1UD41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869634.1">
        <property type="nucleotide sequence ID" value="XM_022016567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD41"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD41"/>
    <dbReference type="GeneID" id="33558376"/>
    <dbReference type="InParanoid" id="A0A1Y1UD41"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012779088" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="833"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115128" checksum="6A9BB1C61B64B022" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD46</accession>
    <name>A0A1Y1UD46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870089.1">
        <property type="nucleotide sequence ID" value="XM_022018404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD46"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD46"/>
    <dbReference type="GeneID" id="33560213"/>
    <dbReference type="InParanoid" id="A0A1Y1UD46"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="53"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="443"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="545" mass="58919" checksum="AE14AC9CD6C24D3A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD63</accession>
    <name>A0A1Y1UD63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_516118</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870110.1">
        <property type="nucleotide sequence ID" value="XM_022012977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD63"/>
    <dbReference type="FunCoup" id="A0A1Y1UD63">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD63"/>
    <dbReference type="GeneID" id="33554785"/>
    <dbReference type="InParanoid" id="A0A1Y1UD63"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="560"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="834"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="443"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="776"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX35981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="965" mass="107429" checksum="565F6242A8217FC5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDG3</accession>
    <name>A0A1Y1UDG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_660353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869720.1">
        <property type="nucleotide sequence ID" value="XM_022018892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDG3"/>
    <dbReference type="FunCoup" id="A0A1Y1UDG3">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDG3"/>
    <dbReference type="GeneID" id="33560701"/>
    <dbReference type="InParanoid" id="A0A1Y1UDG3"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="284" mass="30860" checksum="2E3D921697B9C3BF" modified="2017-08-30" version="1">MSDDPMADFLAREKAALGDDAELFATGSAPTAPSGVDLTSMSEQTSCTGRPPAKSPSPRPSGMDAFPSLDSPGINGSEFRVTGVAGTGQDEEMEKFTSAFPDLSDEVRAEAPPKPVFNALAAQPYGSSPYANTAPPKSSTSILPPPPLQNTLPEAQEDTEPIKEWRARQAEEIKRRDENDRKARDEMKNKAEKSIDAFYEEYNKLKEKNIRENKENEAAFLEKLRDGTAKGSAWERVTELISLENSQSKTIRPSVPGGSDLARMREILLALRREGDKAPGAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDL3</accession>
    <name>A0A1Y1UDL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">BD324DRAFT_630852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDL3"/>
    <dbReference type="FunCoup" id="A0A1Y1UDL3">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDL3"/>
    <dbReference type="InParanoid" id="A0A1Y1UDL3"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="345" mass="37591" checksum="CEC9F6474EC5DFA2" modified="2017-08-30" version="1">MSVTVTADQLAALRAILLNSSGKTPLHERFRALFMLKAVGNDQVVNIISEGFEDDSSLMKHELAYVLGQLSNPLAIPKLEEVLVNDKQQHCSMVRHEAAEALGALSSESSLPLLRKYLDDPNREVRETCEVAIGKIQFDHGAEGKERMKNPDFPTIDPAPSSSREDIPALRAALLDTSRPLFERYRAMFALRDFGAASKDAVLSLAEGFGDSSALFRHEIAYVFGQLCSPHSIPSLLSRLEDAQEDPMVRHEAAEALGGIASDGIEGDEEASRVLPPGGVLQILREWAIKEGAPQVVKESCQIAIDMWEYENSQDQFNPLDTLVSKAHTTGMERSAASAVAAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDW6</accession>
    <name>A0A1Y1UDW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_580696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870342.1">
        <property type="nucleotide sequence ID" value="XM_022013455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDW6"/>
    <dbReference type="FunCoup" id="A0A1Y1UDW6">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDW6"/>
    <dbReference type="GeneID" id="33555263"/>
    <dbReference type="InParanoid" id="A0A1Y1UDW6"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="18"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="587" mass="68487" checksum="E7B1C125A927CFE0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDX1</accession>
    <name>A0A1Y1UDX1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_609449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869901.1">
        <property type="nucleotide sequence ID" value="XM_022014155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDX1"/>
    <dbReference type="GeneID" id="33555963"/>
    <dbReference type="InParanoid" id="A0A1Y1UDX1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="720" mass="79811" checksum="FFB93718A36523D7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE28</accession>
    <name>A0A1Y1UE28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ESCO1/2 acetyl-transferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_651542</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870402.1">
        <property type="nucleotide sequence ID" value="XM_022018349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE28"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE28"/>
    <dbReference type="GeneID" id="33560158"/>
    <dbReference type="InParanoid" id="A0A1Y1UE28"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="47168" checksum="CB01F433C37049E8" modified="2017-08-30" version="1">MSEKPIIRRTYGKISKPSSSSSAILFFPDPVGSSSNDNSQNRSLLLQDAGPRSSSPLLSSILGTPNGSTDRAEDVFAAGSSSPMQRRSSPSPLLDDIDLKKASGIASSILRQVSTQSSLKSFFGIPSSTKRPLKPTHTVSSPTTTAPASNARAESSKSARHLTQMHLTHLPLFHTCKECSMSYLRGGGEDESVHAKHHLRVVHGIPWDGLGKSSKASKSASRGVSGSSSERSQVKSGGWTVVQSDVEFGQGKQRGVGRVVMCDGSWGGTKASLLEICHMVDTVLSAPALPTPILDTCKIFLFLTTSPAPSGKRLRPGSSAKGSNKERIVSVVVAQPIKTAMRVLKEMESVDHQVDSGGGVVCDPTLLPTPLGIHRLFTVPAYRNLSLSRTLLNAACEHTIYGMTIDPSKGHVAFSQPTDSGKKVMLKWGGGSIRVFVDDERQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEE3</accession>
    <name>A0A1Y1UEE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_628681</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870493.1">
        <property type="nucleotide sequence ID" value="XM_022016136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEE3"/>
    <dbReference type="FunCoup" id="A0A1Y1UEE3">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEE3"/>
    <dbReference type="GeneID" id="33557945"/>
    <dbReference type="InParanoid" id="A0A1Y1UEE3"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="414" mass="44873" checksum="C3807CDDCB6E48C4" modified="2017-08-30" version="1">MSTFGDLFRVHTYGESHCKSVGCIIDGCPPGLKLTEEDIQVQLSRRRPGQSDLTTARSEFDTVHLQSGTEHNVTLGTPIGLLVHNKDQRPHDYAETDLYPRPSHADYTYLAKYGIKASSGGGRASARETIGRVAAGAIAEKYLKEAAGVEIVAFVASVGKVELPFAQGEDEVLGKEFVELLRTTTREQVDKELTRCPHRETSDKIADAIRSAKSREDSLGGTIICVIRNCPLGLGEPAFDKLEAVLAHAMLSIPSTKAFEIGSGFRGTQFLGSQHNDPFVDGVDARTGQKRLRTSTNWSGGSQGGISNGEDVYFRVGFKPPATISQQQNTAKYDGSTGVLETKGRHDPCVLPRAIPIVETMAALVIMDMFLKQNARSSAASLLEPVDHLPPSMILPGKNKVVETQLVEDKVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEF1</accession>
    <name>A0A1Y1UEF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_656836</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870509.1">
        <property type="nucleotide sequence ID" value="XM_022018850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEF1"/>
    <dbReference type="FunCoup" id="A0A1Y1UEF1">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEF1"/>
    <dbReference type="GeneID" id="33560659"/>
    <dbReference type="InParanoid" id="A0A1Y1UEF1"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="14">
        <location>
            <begin position="103"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX36408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="387" mass="42494" checksum="7DDF0B62EEA347D8" modified="2017-08-30" version="1">MSNVQPETSAPVTGQGSTAQAQMLNLDIIIRVLSKTIFAPSFCIFIPLTFLSQLRSTSHPVFIWSCVWTALVCLTHTLLHIDRLYSNQWSWLFSPSKLNWGDQVVLITGGGSGIGALLAETLAMRNVTVVVLTKTPAKLEVQNDNVHTYVCDVSDLDAVEKVAVQVREEVGDPTILVNNAGVVKGKLLLDLNEEDIKDSFGSNTLAQFWTLKTFLPAMIRAGHGHVVSLTSVLGLVGAAQMTDYCASKAALVSLHQTLRAELDARYLAPNVRTTLVIPAFVHTNLFACVKLPTSRLFNFLAPHLEPHVVVKEIIDALDCHESRVIRLPWYTNLARIMGPGVGIVPKWLADLLQWIAGADQAMSEYGPKPDAGERLLVERRVTDQKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF23</accession>
    <name>A0A1Y1UF23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_454920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870658.1">
        <property type="nucleotide sequence ID" value="XM_022012826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF23"/>
    <dbReference type="GeneID" id="33554634"/>
    <dbReference type="InParanoid" id="A0A1Y1UF23"/>
    <dbReference type="OrthoDB" id="2562728at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="147" mass="16504" checksum="F7218F303655F9BD" modified="2017-08-30" version="1">MTSEYQSGAPWTDKHTVALTRAIVSLVLANRTTLYTDPELLEVANNHGDRIRKKTHQILHKLVDRVPGAEQIMADELTKTASVRSLRKKAGQGNDCGVANPGLRIKKELDTQPITKKRKMVDDEIAEWLDLPEDDEELADDTFIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF42</accession>
    <name>A0A1Y1UF42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_631241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869859.1">
        <property type="nucleotide sequence ID" value="XM_022016416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF42"/>
    <dbReference type="GeneID" id="33558225"/>
    <dbReference type="InParanoid" id="A0A1Y1UF42"/>
    <dbReference type="OrthoDB" id="2565180at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="865" mass="94498" checksum="1B0453E6C3ABBFA2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFB0</accession>
    <name>A0A1Y1UFB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_660979</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869929.1">
        <property type="nucleotide sequence ID" value="XM_022018894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFB0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFB0"/>
    <dbReference type="GeneID" id="33560703"/>
    <dbReference type="InParanoid" id="A0A1Y1UFB0"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="14">
        <location>
            <begin position="206"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="705" mass="80631" checksum="7E63DBA230BD89C0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFB9</accession>
    <name>A0A1Y1UFB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_681509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870812.1">
        <property type="nucleotide sequence ID" value="XM_022019123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFB9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFB9"/>
    <dbReference type="GeneID" id="33560932"/>
    <dbReference type="InParanoid" id="A0A1Y1UFB9"/>
    <dbReference type="OrthoDB" id="2562918at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666035" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="135" mass="14474" checksum="D1C6BB53CC0E3C5C" modified="2017-08-30" version="1">MLPEVAVAILGLGASVLTISSPDELFQCEPATFSWTPNLGPYILSVTLSDLAPTFNLSMEDQEAWVDGAEMVISIPEASTATWIVDLPEGLNVTTHIKDAEGHIASGYPRVIGPGHGACLMAAEWSEYEDWARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFE6</accession>
    <name>A0A1Y1UFE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-fucosidase</fullName>
            <ecNumber evidence="2">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_651265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870850.1">
        <property type="nucleotide sequence ID" value="XM_022018303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFE6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFE6"/>
    <dbReference type="GeneID" id="33560112"/>
    <dbReference type="InParanoid" id="A0A1Y1UFE6"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="6">
        <location>
            <begin position="83"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="477" mass="53279" checksum="963B141D89005BD6" modified="2017-08-30" version="1">MKNLVQLSLQGLRWILGDASSSASPSHPHYRLSPIDGSKIALPTPQQLAFQDKEIGVIIHFNIATFISSDGCNFQRHLLPDRDIFSPDQLSTDNWMEAITALGAKTATYVAKHNCGFTTWPTKISFPSTHGNGIVPYNYSIQHSPLAGQNIVAQFTESAKRYDVDPGFYYSLDYNNFLNVYNFDVNDTGLASGQVPITRETYDNIVMAQLEELWSSNGKLTEIWFDGGFVDSQIDRLRKLLAKYQPDAVCFNGCGADGSCVTPNPIRWVGTEEGHAPIDNWSTGVSNDGGDPESEFFAPAECDTATYANGRWFWGEGVAARSYAQMVQLYHETVGRNCFLELGVSPNRHGLIDPEHAEVYAQLGQFVRECYDHPVEYTRKIHKDGSIEFSFDEPTSIDRVVLMEDQTNGQVIRSYGVFAQIEGQGKSWQKLSGGKSVGHKKIDLFDETVKVTRVMVNSTFVDTPKWRDVSLHLCDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFK9</accession>
    <name>A0A1Y1UFK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_580559</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870418.1">
        <property type="nucleotide sequence ID" value="XM_022013444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFK9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFK9"/>
    <dbReference type="GeneID" id="33555252"/>
    <dbReference type="InParanoid" id="A0A1Y1UFK9"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="931"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110695" checksum="C26DAF4C2C18E5AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL7</accession>
    <name>A0A1Y1UFL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870428.1">
        <property type="nucleotide sequence ID" value="XM_022016114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFL7"/>
    <dbReference type="GeneID" id="33557923"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL7"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18962" checksum="510AA976F65B311F" modified="2017-08-30" version="1">MDWHKTILAITSATTSYIFFGALADQQRGIVPLATGRIKNTAGLTPANRVGLFASFLPRAAIPIVLIANISIIMAFTTSYYHPDRIIRQIAFTSAGFLLLLAPLTLGQHLPAINSQLLAFSRAGPKEIEAKGELINQLIITWERKHLWRFISYVGAWACSIAALSIDSGRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFR6</accession>
    <name>A0A1Y1UFR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_651615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870478.1">
        <property type="nucleotide sequence ID" value="XM_022018361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFR6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFR6"/>
    <dbReference type="GeneID" id="33560170"/>
    <dbReference type="InParanoid" id="A0A1Y1UFR6"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="181"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="849" mass="93659" checksum="4D9A112654EC4BC3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFX1</accession>
    <name>A0A1Y1UFX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_651874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870094.1">
        <property type="nucleotide sequence ID" value="XM_022018406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFX1"/>
    <dbReference type="GeneID" id="33560215"/>
    <dbReference type="InParanoid" id="A0A1Y1UFX1"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="5">
        <location>
            <begin position="714"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="842" mass="93529" checksum="8F6997F85AB93EA7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG65</accession>
    <name>A0A1Y1UG65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_580977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870605.1">
        <property type="nucleotide sequence ID" value="XM_022013477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG65"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG65"/>
    <dbReference type="GeneID" id="33555285"/>
    <dbReference type="InParanoid" id="A0A1Y1UG65"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="665" mass="75156" checksum="AEE2FE116CAF6603" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGX8</accession>
    <name>A0A1Y1UGX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_489113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870436.1">
        <property type="nucleotide sequence ID" value="XM_022012926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGX8"/>
    <dbReference type="FunCoup" id="A0A1Y1UGX8">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="33554734"/>
    <dbReference type="InParanoid" id="A0A1Y1UGX8"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="16"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="37738" checksum="0DAAACE1F569E8CF" modified="2017-08-30" version="1">MAQSEQHSRLAVLGTVVFYMVVAISMTLLNKNVLSSTPLPVFLLFCQSAMAVFLLALENRLGPIKTPATFEMPIAKELAPLVGINVLGLIFNNYCLQYVDASFHQVARGLVLPCTILITIFVLKQYPSRLSLIAALIVTSGFFSGVLFDPNHASSKASAAVAKPHSSVLGILFGASSSIASACHAILIKKSLTAVQGSAIALSYYNNILSTLALIPLVIICGEGPGALRLLSGEHDAKTFFWGAGITGVFGFLISLASFISIKVTSPVTHMISSAARGVLQTMLAVYFFGDIISSGRMVSIALIITGSVLYVYSKSLPESDSKAPYSPLDSKSVNGTPTLFDAEEGKSTKDHNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGZ7</accession>
    <name>A0A1Y1UGZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871356.1">
        <property type="nucleotide sequence ID" value="XM_022015824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGZ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGZ7"/>
    <dbReference type="GeneID" id="33557633"/>
    <dbReference type="InParanoid" id="A0A1Y1UGZ7"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="261"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="337" mass="37515" checksum="8C48983CD42056E2" modified="2017-08-30" version="1">MSKTRDALGKPETLTYHTTPRGHQVKIDVRGKGGPALITFHGGGIIQGSRVDGHIPSNWEAKFPGTWIAADYRLLVPSVGSDILEDIRILLDYVLTLPIDHHKIFLFGGSGGGYPMRLAAMLAAQESQKPEPRYTVIGCISYCGMAGDFLLDHWFKPIIPRDMNISEEGIKQKVDSLKPDLDHMRGGEEQSDCSFDVTRNPNRDVIWQTWHLTGTINDSITGDQGFSEKMKSIPYEKRLESIPEKLVPFLPQAFIEKNGAILPPFLLVHGNKDTIIPYEESVNTERAIKASGGKAELFTVEGADHDMKKPGEASDAITESDEYALKWMNERIREATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH74</accession>
    <name>A0A1Y1UH74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_475854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870946.1">
        <property type="nucleotide sequence ID" value="XM_022012890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH74"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH74"/>
    <dbReference type="GeneID" id="33554698"/>
    <dbReference type="InParanoid" id="A0A1Y1UH74"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30562" checksum="21E7F9942DFAA11A" modified="2017-08-30" version="1">MSNGMSWLELTIFSSQDDKPMPISTDPYDAQLFHPAPSYPSSYPGARPQAVSGKEIGIDPGVLGGFHNVSTGAHVADDAETDPASPALRPISPHETIPDPPGVRRSSRPKLRPRSDSYLNKLRQSSNKSILEEDEDHDDDDDDDKIMRDEADSPERLEPIDMADEDELEQLRLLEMGGPAMKKDKRRLQNKLAQRSFRARSRIVRREAANHLADVEVKTVNQMEELKLLRIMVENLRKENLELKRRFSEDFPMPSPTISKSGSGRKRKASGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHC8</accession>
    <name>A0A1Y1UHC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_451962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871496.1">
        <property type="nucleotide sequence ID" value="XM_022012820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHC8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHC8"/>
    <dbReference type="GeneID" id="33554628"/>
    <dbReference type="InParanoid" id="A0A1Y1UHC8"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="638" mass="71974" checksum="D77671148A83DB21" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHF9</accession>
    <name>A0A1Y1UHF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_627855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871036.1">
        <property type="nucleotide sequence ID" value="XM_022016053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHF9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHF9"/>
    <dbReference type="GeneID" id="33557862"/>
    <dbReference type="InParanoid" id="A0A1Y1UHF9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="136"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="386" mass="42908" checksum="AFB7739A01603F50" modified="2017-08-30" version="1">MTNSQQSATNGYTHMANGAKLKPTPAEREVMEAQALSEKATSMVEAPDRDWIKSLAALNIDFKAIPSGLDYVGMRRWLKDSYEKVDRKFNHHSWRTPTRVSKSEVMLENGDDEGSFRCVIWEPEEVATDETSRPVILMYHGGGFIHGFPELDEDLAVVLASDLRAVVVGVDYRLAPEHKFSTILNDCRSAVEWIIEHADRYNVDAKRIGLWGASAGAHLAANVAMLEALAHEPSRICQASLVVPLLCHVDECPNPLSDVQAEARQRMDDGPKQALDMAMIGARELFNFMRPDGVRDDDPEISPLRRPGPWPSHHAAVHVTVGGCDLLRDQGIAYYMALQDNGIEAELQLIPGVPHGFTWASRSRAVSQWLDGQIKVFELAFRGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI07</accession>
    <name>A0A1Y1UI07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_579232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871616.1">
        <property type="nucleotide sequence ID" value="XM_022013365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI07"/>
    <dbReference type="FunCoup" id="A0A1Y1UI07">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI07"/>
    <dbReference type="GeneID" id="33555173"/>
    <dbReference type="InParanoid" id="A0A1Y1UI07"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="427" mass="45364" checksum="4FAF86ACF3D522FE" modified="2017-08-30" version="1">MAETYQKKELLELMNTGDNKVCVDCGNHNPQWASVSFGTFICLECSGIHRGFGVHISFVRSITMDKWSEEQLKKMRLGGNEAFKTFMDKYPASGGYTKGMGMQEKYNSWAAAQYREKLAAACADPPTSWSPSAPPPGWGVPSRPVSAQATRKSRAGGIGNQSSPTPSSGRASPGGASGPGGGSGNEAFFERLGAANASRRDDLPPSQGGKYAGFGSNYEPEYTSSSSSHPSFATSSHSAPTLDEFQKNPWGAVSKGWGVFSSALASAGKEINTSIVQPGMSRAQAFASETDQTEWRKYLDQGLDGAKTAAGWAGQKAGEGWGQVNQLAKQNAGVDLDEKLRSLNLGGGGGNRGASQAGYGRLDRGEDGFGGSYSDYEHQGGGYQDDDDDNSWGASGSHEPESAKTGKATQKETKAKDWDQDDEWKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI58</accession>
    <name>A0A1Y1UI58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_579603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871214.1">
        <property type="nucleotide sequence ID" value="XM_022013392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI58"/>
    <dbReference type="FunCoup" id="A0A1Y1UI58">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI58"/>
    <dbReference type="GeneID" id="33555200"/>
    <dbReference type="InParanoid" id="A0A1Y1UI58"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="27"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="862" mass="95150" checksum="51BDC923CB9F6AB8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI60</accession>
    <name>A0A1Y1UI60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_623102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871728.1">
        <property type="nucleotide sequence ID" value="XM_022015550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI60"/>
    <dbReference type="FunCoup" id="A0A1Y1UI60">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="GeneID" id="33557359"/>
    <dbReference type="InParanoid" id="A0A1Y1UI60"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="147" mass="15521" checksum="1E9A16FB18601961" modified="2017-08-30" version="1">MASNHAEGSTGPSGSSPALPSVSPAPAGGSRSGSSWSEVGQALKTIRPVEDLKNVGSIPCGRDSLLYGIGGGVGIGCLRYLSSSNPRVAGNWAVGSFMLIAIYQWEACRGERKRQEEKLKVLSEKYPHRHVSNLTKGRPNDENSNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI86</accession>
    <name>A0A1Y1UI86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871748.1">
        <property type="nucleotide sequence ID" value="XM_022015560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI86"/>
    <dbReference type="GeneID" id="33557369"/>
    <dbReference type="InParanoid" id="A0A1Y1UI86"/>
    <dbReference type="OrthoDB" id="2553859at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12763" checksum="C58BC19D318EA88A" modified="2017-08-30" version="1">MSESGPPYLHARYQIVSIDWNVPLDSNTKLARNGNLSQTVTTSLDPQSYYRDLSVAVLAVQQKLNDELTRWKEHVGDAERFKEGAGQAGDKLPSSTRHATGGDEVSDDQSGDEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIC1</accession>
    <name>A0A1Y1UIC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_623377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871788.1">
        <property type="nucleotide sequence ID" value="XM_022015571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIC1"/>
    <dbReference type="FunCoup" id="A0A1Y1UIC1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIC1"/>
    <dbReference type="GeneID" id="33557380"/>
    <dbReference type="InParanoid" id="A0A1Y1UIC1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="79"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="565" mass="61631" checksum="B5C1579BDAA9C66F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIZ2</accession>
    <name>A0A1Y1UIZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_641753</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871514.1">
        <property type="nucleotide sequence ID" value="XM_022017444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIZ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UIZ2">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIZ2"/>
    <dbReference type="GeneID" id="33559253"/>
    <dbReference type="InParanoid" id="A0A1Y1UIZ2"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX37527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="45386" checksum="D930F20E175ECC9A" modified="2017-08-30" version="1">MASNEDAGQPLFPDAGPSNPHRPSIFEFLGQDQLRDLFHPVIRYILSYFAQRYPRYLLRILNHHEEFFACVMLLIERHHLKKHNASVSEHFHQLYHVQATRYPRTHSSAFQRPGRLTRRQRWGLLVFLVGIPYLRARAHSYYEELGVGVNDRDSEISVLPRVSLPVPHRSHVQRAKLFKAIYPYLNLTLDATFLAYDLRYLFGASDVYRPWHAWLGTSIQRREQDEIEGSDSTWTRLVPPLLPPLLLALKLSQWWYSPSSPRDISLNFDTNIRSKIHRAIPPPKPLPILPQSGLLPQRSPPGSPPEMADPSATGPDLIYTVDDEMYGKCPLCNKNWQNPAILPSGWVVCWRCGWDAIAGTDDVDQSGGTSENTRRRGKCPFTGMDVSVGQLRRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJE7</accession>
    <name>A0A1Y1UJE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_641481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872112.1">
        <property type="nucleotide sequence ID" value="XM_022017422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJE7"/>
    <dbReference type="GeneID" id="33559231"/>
    <dbReference type="InParanoid" id="A0A1Y1UJE7"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="515" mass="56753" checksum="19EC30327E2AE274" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJY2</accession>
    <name>A0A1Y1UJY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_449992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871473.1">
        <property type="nucleotide sequence ID" value="XM_022012816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJY2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJY2"/>
    <dbReference type="GeneID" id="33554624"/>
    <dbReference type="InParanoid" id="A0A1Y1UJY2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="111"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="388"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="71791" checksum="6CF5BD67E960E95E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJZ8</accession>
    <name>A0A1Y1UJZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_577597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872312.1">
        <property type="nucleotide sequence ID" value="XM_022013269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJZ8"/>
    <dbReference type="FunCoup" id="A0A1Y1UJZ8">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJZ8"/>
    <dbReference type="GeneID" id="33555077"/>
    <dbReference type="InParanoid" id="A0A1Y1UJZ8"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000006">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59604" checksum="D3DD4842E7E681EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK91</accession>
    <name>A0A1Y1UK91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872402.1">
        <property type="nucleotide sequence ID" value="XM_022018052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK91"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK91"/>
    <dbReference type="GeneID" id="33559861"/>
    <dbReference type="InParanoid" id="A0A1Y1UK91"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="28"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="874" mass="96914" checksum="7DBC1A07BF1F64CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKR7</accession>
    <name>A0A1Y1UKR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_621407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872484.1">
        <property type="nucleotide sequence ID" value="XM_022015377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKR7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKR7"/>
    <dbReference type="GeneID" id="33557186"/>
    <dbReference type="InParanoid" id="A0A1Y1UKR7"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="914"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1157" mass="125522" checksum="74A0A09B8C6E8CB9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL01</accession>
    <name>A0A1Y1UL01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_599616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872591.1">
        <property type="nucleotide sequence ID" value="XM_022013905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL01"/>
    <dbReference type="FunCoup" id="A0A1Y1UL01">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL01"/>
    <dbReference type="GeneID" id="33555713"/>
    <dbReference type="InParanoid" id="A0A1Y1UL01"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000143">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="613" mass="67843" checksum="82D9E28D5EA9F06B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL07</accession>
    <name>A0A1Y1UL07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_577612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872662.1">
        <property type="nucleotide sequence ID" value="XM_022013270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL07"/>
    <dbReference type="GeneID" id="33555078"/>
    <dbReference type="InParanoid" id="A0A1Y1UL07"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="829"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="905" mass="102399" checksum="456ED7C1256CE61E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL31</accession>
    <name>A0A1Y1UL31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scamp family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_649634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872179.1">
        <property type="nucleotide sequence ID" value="XM_022018025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL31"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL31"/>
    <dbReference type="GeneID" id="33559834"/>
    <dbReference type="InParanoid" id="A0A1Y1UL31"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF90">
        <property type="entry name" value="SECRETORY CARRIER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="310" mass="33921" checksum="5B4FF3E63E3C4324" modified="2017-08-30" version="1">MSRNQDTENPFEPSSHLDSNPFENQSAKNPFQHPNDSAFSFDSQDTARGLGRAEAGQAGTGYGYGAGRGGSNAPASSGAADPYAAREADLRRREEELRRRETALGMKENNWPPFFPFIHHNIQELPDDHQPVMKFLYTQWLALIVTLIVNLVGCVLLLISGSSEGGADTAASAGYLPVIGALSFILWYRPIYLGFERTEGKAMAFFFYLYFAFAGCHLLFSIYMAVGIPSTGSAGLINTIQMFSQGHILAAIFCLLASIGWVLQVAGGGLLYKKVWDFKNSNGDITFAEATNQFKKNSITTILLHQARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULB5</accession>
    <name>A0A1Y1ULB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_292692</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872696.1">
        <property type="nucleotide sequence ID" value="XM_022012398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULB5"/>
    <dbReference type="FunCoup" id="A0A1Y1ULB5">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULB5"/>
    <dbReference type="GeneID" id="33554206"/>
    <dbReference type="InParanoid" id="A0A1Y1ULB5"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="108"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="182" mass="21381" checksum="0F51A7D32FAF1391" modified="2017-08-30" version="1">MRKLKHHEQKLLKKVDFLNWKQDASQREVKVMRKYHIQDREDYHKYNKLCGSLRSLIHRLSLLPAEDPYRQQKESEMLNKLYDMGILDVGSKPSDIENKVTVSSIARRRLAVTVARLKMAETVSDAVRTIEQGHVRVGTQPVTDPAMLITRHMEDFVTWVDTSARKRTIMKYNDELDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULH5</accession>
    <name>A0A1Y1ULH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDHD domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_617834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872763.1">
        <property type="nucleotide sequence ID" value="XM_022014950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULH5"/>
    <dbReference type="FunCoup" id="A0A1Y1ULH5">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULH5"/>
    <dbReference type="GeneID" id="33556758"/>
    <dbReference type="InParanoid" id="A0A1Y1ULH5"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="608"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="836" mass="91666" checksum="737CB373334BE1A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULV7</accession>
    <name>A0A1Y1ULV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_620967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872388.1">
        <property type="nucleotide sequence ID" value="XM_022015345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULV7"/>
    <dbReference type="FunCoup" id="A0A1Y1ULV7">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="GeneID" id="33557154"/>
    <dbReference type="InParanoid" id="A0A1Y1ULV7"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000905">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="181"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="357"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="617" mass="69425" checksum="62A1738AD80C556E" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULW4</accession>
    <name>A0A1Y1ULW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HCNGP-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872845.1">
        <property type="nucleotide sequence ID" value="XM_022014988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULW4"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULW4"/>
    <dbReference type="GeneID" id="33556796"/>
    <dbReference type="InParanoid" id="A0A1Y1ULW4"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="303" mass="34791" checksum="85F7F396216A2A60" modified="2017-08-30" version="1">MQGLARYSDNSPSPPAAGPSRPRNDSSLGQSQRPRHSSPSSSHHEGVRNAKRRRSKSPENLTHTSQAHLAHSALAASDVAVYERNMEARLEAEAEMTEEEMFRRVTRPPDIDGLEDWGIPPEVDPGECSTQLRDKVAQFLDLKYSRGQHINTSLLSSTTFANPHIYAKLVEFVDLSERATAFPSGGWLTRQGLEYLRPKYGPKALGDEQKRKQEEVRKAQEVGKRNSISFAPGRHADDRDVRGVDRSKDNRDARRDSDRVRHGHRNDRDRRDSHRDRSGRYHKDGGWEERDMKRDKREWDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM13</accession>
    <name>A0A1Y1UM13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_619867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872097.1">
        <property type="nucleotide sequence ID" value="XM_022015217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM13"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM13"/>
    <dbReference type="GeneID" id="33557025"/>
    <dbReference type="InParanoid" id="A0A1Y1UM13"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="406"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="568" mass="63712" checksum="DF89ECD4512B5B0D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNC6</accession>
    <name>A0A1Y1UNC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_577279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872890.1">
        <property type="nucleotide sequence ID" value="XM_022013249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNC6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNC6"/>
    <dbReference type="GeneID" id="33555057"/>
    <dbReference type="InParanoid" id="A0A1Y1UNC6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="142"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="415" mass="47122" checksum="EF65EB724113DC4C" modified="2017-08-30" version="1" fragment="single">DIDLSQATLSSLVRLLREELVQLCETRSLDTAGTKPQLAKSLLAWYEKQQEGIETHSTSSSQATARPESPRKRKGKIIHAIASNVHVSGKTTPVLLRDHIHATDPQTPPHSDDDDRRAGDGDINLDLQELGLEDSIIKPEQLQKLERIGSGGFKDVYVGKFRGRRVAISEFRGHLSEMDIRELKLLAEFSHPNIVKFKGICIPEDTSQVPCMLVSELCENGDLFDYIRNVEPPSANKVHRLMLDIARGLEYLHTRKPAIIHRDCKSSNILINRAGHAKVGDFGLARVKTSTRSMIRSLVGTVNWQAPELWHPHPRYDFKVDVFSAAMVFWEMLSGWTGEKKYPWEGHNEHYIYDAVGTKQKRPSVARLRKHWGNEVVDLMEKMWSQEPSDRPTMTEVVNELDALYFKGPFTPLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNL0</accession>
    <name>A0A1Y1UNL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphase-promoting complex, subunit 10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_618536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872970.1">
        <property type="nucleotide sequence ID" value="XM_022015043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNL0"/>
    <dbReference type="FunCoup" id="A0A1Y1UNL0">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNL0"/>
    <dbReference type="GeneID" id="33556851"/>
    <dbReference type="InParanoid" id="A0A1Y1UNL0"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="214" mass="23774" checksum="691EA5F42FA0AEAA" modified="2017-08-30" version="1">MEDVTFESTSTDVERPELGHLPTWSVSTHKYGFGVDNLRDGNDNTFWQSEGPQPHTIDLSFPKRVFISAISLHTSHPRDDSYTPSKISIKAGTSIHDLQEVRFCEFSKPNGWMHIPLRPMDSSSEGQEIDGPPIPAHHLRILILANHLNGKDTHVRGLKVFGSPVQANAPSSLDASEANTPTRATAAGKRLLELGHDGLSDFTSQQFKMHEFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNM1</accession>
    <name>A0A1Y1UNM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872929.1">
        <property type="nucleotide sequence ID" value="XM_022015026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNM1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNM1"/>
    <dbReference type="GeneID" id="33556834"/>
    <dbReference type="InParanoid" id="A0A1Y1UNM1"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="481" mass="51349" checksum="D7AEB9E4375FCA8D" modified="2017-08-30" version="1">MPPKSKKTKAEEAADFLSSLDNLDAPPAGIETAPSTSAPIAAGELPRASTDSARPKSIKSSTDLSNSVDLGRSKTATPPPPVVEAENDEANEALAFLQAQINTKRAPLSAPKPSAPRAATPQSSSATAAAPSSSSSATLASAPVNVPTASAASGASSGWGSSWWSSATSALQNAQKIADEGYKRVRTEGVAGVSEQLKGVDLNKLRQGAEERLGGIVKGVDLEKLREDLLKHTSSTLTTILDTVAPPIAAHETLELWLAHPMSGYAGVEGVVYRAWTKILEQTESGELIVMWSAEDPAQEDMERNMNPVEGFETGWKRQNEQIVKVREREEENPQGRARANPSVPVTTVPIFLHLQPVLAPLSIPEPPILLSQSKSEPGSAPTPPKHLYFLMTLQDPSHSLRFTTVSQPAPADWLDVEYEKSDWVEERLVEVLRNGVEIIAQDYVATRMGMKPSIATPATPTEPKETSAAPAETSQEDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNP8</accession>
    <name>A0A1Y1UNP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_618466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872949.1">
        <property type="nucleotide sequence ID" value="XM_022015029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNP8"/>
    <dbReference type="FunCoup" id="A0A1Y1UNP8">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNP8"/>
    <dbReference type="GeneID" id="33556837"/>
    <dbReference type="InParanoid" id="A0A1Y1UNP8"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="222" mass="23236" checksum="D07CB558C223839E" modified="2017-08-30" version="1">MSDPTIKGLGPAPTSYDGSPFRIAIVHARWNDTVIQALVQGCIAKLKSIGVKDSNIVVKSVPGSYELPFACQRLIEGGKTQSAKSASSMLSSTTNLLSLIDSVGSSTPKDATSPTQTKESQTSAGPSTAPFSAIIAIGCLLKGSTMHFEYICDAVTHGLMRVQLDSGTPVIFGVLTCMTEDQALERAGIGRKGDKGHNHGEDWALAAVEASAQVADWSKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNT3</accession>
    <name>A0A1Y1UNT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thaumatin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_314240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873027.1">
        <property type="nucleotide sequence ID" value="XM_022012464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNT3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNT3"/>
    <dbReference type="GeneID" id="33554272"/>
    <dbReference type="InParanoid" id="A0A1Y1UNT3"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013">
        <property type="entry name" value="THAUMATIN FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31013:SF2">
        <property type="entry name" value="THAUMATIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012937425" evidence="2">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="425" mass="43457" checksum="FA6885C2187453FA" modified="2017-08-30" version="1">MLTTLVLALLILPALQTQVSGGRTIHVVNSCGSNVYPAYAGKGDQVTLSSGGVAPPAWELAAGGTTDLIVPDNWESGRIWLRSGECNGNVEKCKIGACVGGGNNCDGKAYGSLGATIAEFGMGGAEYGDFYDVSMVEGFTVSMSITPSTSSCTVASCGAETDILRQCDPRLVWPKGSDQIWGCAAACSAGIFYLGQGVTTFDWQDCPSCCNGAYLYNCPASNFPFYDVYKPMCKMGYVFAKDDVVPNQTAVLNCPSGASYTLELCAGGIKSGITDPPSSSEAVTQDPGGEINIGDGSGSGGGGGGASKGSSAMGGGGGISTSGGPFPAPSPSSSNHQVGFSMTSQADPLPSLSTTVYQPPVPVSSETGWGGWGNGNHHGGNGHHHWQTGGQHLGAWEQSPSASASEAKHCTPKSKRGIEKQRQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNW7</accession>
    <name>A0A1Y1UNW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_614796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873523.1">
        <property type="nucleotide sequence ID" value="XM_022014645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNW7"/>
    <dbReference type="FunCoup" id="A0A1Y1UNW7">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNW7"/>
    <dbReference type="GeneID" id="33556453"/>
    <dbReference type="InParanoid" id="A0A1Y1UNW7"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="548" mass="61099" checksum="AD2A603A81D6C143" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP88</accession>
    <name>A0A1Y1UP88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNase P subunit p30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_615226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873633.1">
        <property type="nucleotide sequence ID" value="XM_022014697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP88"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP88"/>
    <dbReference type="GeneID" id="33556505"/>
    <dbReference type="InParanoid" id="A0A1Y1UP88"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="344" mass="37495" checksum="6082C8869611875E" modified="2017-08-30" version="1">MYFDLYLPFPIPRSNDIPKKKKDKSKGKGKAEDSSAAESVPQSCWAGLEEGEREGFARSMALSGHLGYSIVGCTVNPSTSALAHVSPFLRALPYPQLDPRSREDGKSGQSSNQGLTMVQVSRLHLHLDDSRTHCLTGANSAVLKEYDIISVQPLTEKAFQLVCTDLCLPGPNQVSIITLPLHERPYHFRLNRKQVRQAQRNGVMFEILYSAALSPSSASRETARRYRQNFLSNAKELVRITGGKGIILSSGPGGGDDSMRGPLDLVNLGTMLGMPANLAKDAVSANPKRVLLNAQARRTFKGVMTMPKMVDPPEPSAALVEAEGRAKRQSDTGQLQEAKRVKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPD5</accession>
    <name>A0A1Y1UPD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_615390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873676.1">
        <property type="nucleotide sequence ID" value="XM_022014717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPD5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPD5"/>
    <dbReference type="GeneID" id="33556525"/>
    <dbReference type="InParanoid" id="A0A1Y1UPD5"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="31076" checksum="0EBD7A6CF2FE8414" modified="2017-08-30" version="1">MVSFQCDGCADTVKKPKLDQHRQRCWASFTCLDCSQTFNNQDYKKHTSCISEAEKYQGALYRGPKKGGAQANGERPVKSKAPQEPVKESMASTCASPLPSQSSIHPDRLSQFDAGPAHDFSNAGPSRGRGGFRGRGGPQARGRGGYHGHSLVSGENKLGPKDGMRTWGSPAVTPKETTPEPSASTAREKRPRDTTSTPVEKKKKTKRDESPSSARTAQQDNNDPKLIKRLRKKAAKLGEKGGKMNLDEFTRKLMEGKQETMDLTQLLQHASVHNDGTRWVLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPM5</accession>
    <name>A0A1Y1UPM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_587072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873707.1">
        <property type="nucleotide sequence ID" value="XM_022013750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPM5"/>
    <dbReference type="FunCoup" id="A0A1Y1UPM5">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPM5"/>
    <dbReference type="GeneID" id="33555558"/>
    <dbReference type="InParanoid" id="A0A1Y1UPM5"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="527"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="401"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="839"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1233" mass="139928" checksum="330470620B5F63DB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPV8</accession>
    <name>A0A1Y1UPV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_254203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873846.1">
        <property type="nucleotide sequence ID" value="XM_022012295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPV8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPV8"/>
    <dbReference type="GeneID" id="33554103"/>
    <dbReference type="InParanoid" id="A0A1Y1UPV8"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012960072" description="TM7S3/TM198-like domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="118"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="721"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="333"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="815" mass="88806" checksum="7BE743EC0C6E7FD5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ67</accession>
    <name>A0A1Y1UQ67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_619132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873148.1">
        <property type="nucleotide sequence ID" value="XM_022015127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ67"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ67">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ67"/>
    <dbReference type="GeneID" id="33556935"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ67"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="386" mass="43686" checksum="44FA19185D275C11" modified="2017-08-30" version="1">MSRMGPTKGVAMRVPKNPPGMRKPTTASGRYGGSNRPGGDDGYLYVAGIRDPSHKVTEFKTESDVCPVCHTDRQFNKNLRLLISPCYHKMCESCIDRLFTLGPEPCPQCGRILRKVNFAHQTFEDLKVEKEVSVRRRMAKYYNKNEKDFATKREYNDYLEEAEDITFNLLNDIDVEATEARITEFARKNAEIIAANEKKRALEMINEGEREEVLRKAKEERARMVAEYDRKEEIESERIQQEVLEAVARGDHKLAQDIESRGKREAAVRAEALAAAIPPSIASLLTDPRARSLQASAGSNGEHTQHQPGSPSYSGRFVAYPYSDPSEAPALRWFNLMDDYVDYRPGVIDAKRNKDGKYRGGGFDLGQFWEMEIRTAVEALGIEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR04</accession>
    <name>A0A1Y1UR04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_610993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874169.1">
        <property type="nucleotide sequence ID" value="XM_022014230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR04"/>
    <dbReference type="FunCoup" id="A0A1Y1UR04">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR04"/>
    <dbReference type="GeneID" id="33556038"/>
    <dbReference type="InParanoid" id="A0A1Y1UR04"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="38"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="244"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="349" mass="39228" checksum="53E3E271CC52B996" modified="2017-08-30" version="1">MDRETKPDVKPDIKPSILPRGQGDEDEELGVEAAFDSSNVWSMKIPRFLLEQWERVTEGGVELGTLVVDNNFQPPKISLRLPDTSTSSTEGQDDPMNGNRAGPSRRPRYDTSSIPDQYEVNVPEERAKNTFVFTERVRKWGPIAKGMTDQGNKKKQRAYPKLVARVAHECTVRPMGNQKYLKILAQRQMEAESSRRPIVSLESTGISRAQQNQMAAGLANINSGLGKGFVSLGNRNGPTGEKFVRLERKDLTDKLFALFSEKPYWSITALRQTLQQPDIWVREVLKDIADQVTQGVYINLWKLKDIWKDADSAIMDEKGGIKGEGSDTGDEEDEEGDDEEEPDLEEVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URF9</accession>
    <name>A0A1Y1URF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_678837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873520.1">
        <property type="nucleotide sequence ID" value="XM_022019015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URF9"/>
    <dbReference type="GeneID" id="33560824"/>
    <dbReference type="InParanoid" id="A0A1Y1URF9"/>
    <dbReference type="OrthoDB" id="2595043at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="190" mass="20282" checksum="27E0D2E62B817FAC" modified="2017-08-30" version="1">MDMSDLDLVAQATARERIPGGSVSGSKEFTTSVPVLPVDTLSNGRVNGKESSAQRSEEENDETMRALRDLGDLEIDDVDLSSLSPQDLEVLRPLIEALRISDPSMLPPGLGRDEDGGQGAEGEGEGDLEIARILAQMDAAEHVADDLDGRLDKLLANLGKVEEEIGQGPEDGKAEEGTNVEDKEEAESNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URQ7</accession>
    <name>A0A1Y1URQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_272802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874082.1">
        <property type="nucleotide sequence ID" value="XM_022012344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URQ7"/>
    <dbReference type="GeneID" id="33554152"/>
    <dbReference type="InParanoid" id="A0A1Y1URQ7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="220" mass="24245" checksum="7B346A29BD023666" modified="2017-08-30" version="1">MPFDLDVPLDQALLQGLEGMQFPAFDPAELGDMLQQALDDPTLLSSPTFTSPSTTSPVPDEATKEAIDNMTGPELCAMLEGWLSQSHITSNSTPEVEDMTQPVHGLADVDIDSSFEQSMPRSIWSGSSTPEKHQNQPPFEMIPSPYPEMTIYPNIMPQQNIQYHQYAQPLPPVPVHQAWIPNVLPFDSGEAYYSGGGYMMDGQGYSQPRVMDQNVILSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URS9</accession>
    <name>A0A1Y1URS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_616562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873931.1">
        <property type="nucleotide sequence ID" value="XM_022014838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URS9"/>
    <dbReference type="GeneID" id="33556646"/>
    <dbReference type="InParanoid" id="A0A1Y1URS9"/>
    <dbReference type="OrthoDB" id="2596681at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="30345" checksum="B6B45F7AFF48B600" modified="2017-08-30" version="1">MSFLKKRLNNLIPSESARGALQNVLTVEWGTHKTVIIEVPQAGPSRSNEVEMYGMDTRADHGDYGRLLDDDDDDEDEHGQGSNRKDRRNKRRSQTYSAHTRDHHYHEPHSSRSVSQPLPPPLAPRPLPSRQMSGNPFDESNEVVDHSDMTPDHYDAYDGEFDPLANSGTIPSMPSTIVKTRPTRSFTEPAVRHHEMDPNDVNAHQANQRGFDNPWEGRQWDRSLDLFNENGLPSPISSKGTRDSASTNESNGNPFRQRMSQIGGPYHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URZ4</accession>
    <name>A0A1Y1URZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NUC185 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_574584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874418.1">
        <property type="nucleotide sequence ID" value="XM_022013069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URZ4"/>
    <dbReference type="FunCoup" id="A0A1Y1URZ4">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URZ4"/>
    <dbReference type="GeneID" id="33554877"/>
    <dbReference type="InParanoid" id="A0A1Y1URZ4"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="260"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="596"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="161"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1218" mass="135527" checksum="632ADEFD1B309AF4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US07</accession>
    <name>A0A1Y1US07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_22377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874490.1">
        <property type="nucleotide sequence ID" value="XM_022012221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US07"/>
    <dbReference type="FunCoup" id="A0A1Y1US07">
        <property type="interactions" value="563"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US07"/>
    <dbReference type="GeneID" id="33554029"/>
    <dbReference type="InParanoid" id="A0A1Y1US07"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="121"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="383"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="464" mass="51009" checksum="F8604861CFA258EF" modified="2017-08-30" version="1">MTSLSDLFEFLDSPNPAARQLALQNLVGHTAKNDPERHIFIPSSFAGTSASGGGLLPEKRKQGSEQDDSKIKALKDLGNLCTDQAMMAHDALSALVNLSDNVAVARHLVDKDFLVWLVSYTANTTSPLSPLTAMLLSNLTSHPSLLPQIINLDIPIIPLTLSKHYPPWYLPAAASASSTIHPDWRDTRITKPNAEAGQEEERTVEGLRALVQAFEDGAAEGVKEGKGKRKGDVNFLASVFANISMTPSTRTLLLTPRPPFPQPSTASPSENDEPLLSKIVIYTEHPDLIRRGGALGCIKNCAMDRGSMGWLLASEHDRVRLPSDPSRTVKGVDVLPWVLSPLMGPEEYEMEDMEKLPPTLQFLPPTKEREKDPVLRMMCIEILLLLSTTFTGREALRQRGAYIVVRELHKVETDQAIKDAIERLVSLIQGEEGHETKMEEIDHLVRGQSGTSASKEEDLDVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US84</accession>
    <name>A0A1Y1US84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_647720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874491.1">
        <property type="nucleotide sequence ID" value="XM_022017705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US84"/>
    <dbReference type="STRING" id="4999.A0A1Y1US84"/>
    <dbReference type="GeneID" id="33559514"/>
    <dbReference type="InParanoid" id="A0A1Y1US84"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="347"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="531" mass="57528" checksum="B9580250B240F2BE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI5</accession>
    <name>A0A1Y1USI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_612734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874650.1">
        <property type="nucleotide sequence ID" value="XM_022014432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI5"/>
    <dbReference type="FunCoup" id="A0A1Y1USI5">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USI5"/>
    <dbReference type="GeneID" id="33556240"/>
    <dbReference type="InParanoid" id="A0A1Y1USI5"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="263" mass="29871" checksum="F439F2949AA7A6C2" modified="2017-08-30" version="1">MARGPRKHLKRLAAPSSWMLDKLGGTYAPRPSPGPHKLRESLPLVVFLRNRLKYALNNREVTAIVKQRLIKVDGKVRTDETYPAGYMDVITIERSGEHFRLLYDVKGRFTVHRISPEEANFKLLKVRRHELGAKGVPYILTHDGRTIRYPDPAIKVNDTVKFDFVANKIVEIIPFEVGNLCMITGGRNMGRVGTIIHMDRHDGGFNIVHVKDVLDRTFATRLSNIFILGESSKAQVSLPKGKGVKLSIAEERDQRRRMRAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USR2</accession>
    <name>A0A1Y1USR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dak1 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_640695</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874671.1">
        <property type="nucleotide sequence ID" value="XM_022017362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USR2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USR2"/>
    <dbReference type="GeneID" id="33559171"/>
    <dbReference type="InParanoid" id="A0A1Y1USR2"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase, L subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="392"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX40992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="599" mass="63502" checksum="870DDD7A0C5DE8B2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UST4</accession>
    <name>A0A1Y1UST4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_612882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874691.1">
        <property type="nucleotide sequence ID" value="XM_022014453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UST4"/>
    <dbReference type="FunCoup" id="A0A1Y1UST4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UST4"/>
    <dbReference type="GeneID" id="33556261"/>
    <dbReference type="InParanoid" id="A0A1Y1UST4"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="163" mass="17262" checksum="A406404AB8995AA3" modified="2017-08-30" version="1">MAACLAFVQKSWAATIAKGGHDCNVLSSLTFIHARPGHLRASLKIDQIHVNNHNTIHGGVILALTDTLTSLAISTMGYHPTGVSVNASTEFVRPGGRSGDELIGVGEVVKLGKSLAYTRITFYDPQGRVVAFGSHTKHLGAATAVVKFSSDGEREEPVRSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USW1</accession>
    <name>A0A1Y1USW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874777.1">
        <property type="nucleotide sequence ID" value="XM_022014475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USW1"/>
    <dbReference type="STRING" id="4999.A0A1Y1USW1"/>
    <dbReference type="GeneID" id="33556283"/>
    <dbReference type="InParanoid" id="A0A1Y1USW1"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="2">
        <location>
            <begin position="105"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="43387" checksum="FC6504A556FFBB16" modified="2017-08-30" version="1">MLTSLNFWETVSNGRSTIPPFTMYSFSSDLPPLEPPTIMALGADSDIGGLSTSNATSIPTAAFYDDPGPSSPLSFSSDQYENSVAVATGSHGGGISPGHIGSPSAGPSRPALKRDPNLPRITGSHMSHVALHGNMSLRLPPSQMGKIRTGYVGMRNHFRPTILGGEDAWDLRQYTHIKMQIAYRGWEGWRKRWYCNVQIAGPTGPSNIDVYQLRIELPPSSASTSSRAPLDPFSGVPPRWTTLHLPLSSFVLTNMGSTSPVQVGMDTEGVRSVGFSLLGGGRDNQGLPLGQPGQYLSQKHRDLSQVEDLDPAFNASRAKRRRHRDGTMDRERGGDGHPGGMDRVSITPFSEGYYELCVRYVQAVQYDPMTDDRPSEWDVWEEEQRLAKERQSPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USY9</accession>
    <name>A0A1Y1USY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_43755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874812.1">
        <property type="nucleotide sequence ID" value="XM_022012783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USY9"/>
    <dbReference type="STRING" id="4999.A0A1Y1USY9"/>
    <dbReference type="GeneID" id="33554591"/>
    <dbReference type="InParanoid" id="A0A1Y1USY9"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="400"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="648" mass="70008" checksum="3F077EA4F1128415" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT45</accession>
    <name>A0A1Y1UT45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874383.1">
        <property type="nucleotide sequence ID" value="XM_022014315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT45"/>
    <dbReference type="GeneID" id="33556123"/>
    <dbReference type="InParanoid" id="A0A1Y1UT45"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="23607" checksum="7ADFE90B421063C5" modified="2017-08-30" version="1">MSEKVNKPSIVFPEQQQQQPQQHLPSSMASSSRRDRASSLSIARSPSVLSSSFGTPPDQYQPHTPSSLSPTHPSGTYVQSLSVAPDSYSNSLSLGIKSLALNRTRTLPPASGVPTLDGVGGKSLTRTATVPTTLKEEDEARERYMSGFANDFNSSQVDDEEEYLSDEDVQGVGGLMGGRDYGGFQKPDKKELVWMLSSLGGVLLISVAACLTTVYDWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT84</accession>
    <name>A0A1Y1UT84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_574616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874907.1">
        <property type="nucleotide sequence ID" value="XM_022013072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT84"/>
    <dbReference type="GeneID" id="33554880"/>
    <dbReference type="InParanoid" id="A0A1Y1UT84"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="272"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="574" mass="67105" checksum="FE541F5B40CF54C8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT89</accession>
    <name>A0A1Y1UT89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_648113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874909.1">
        <property type="nucleotide sequence ID" value="XM_022017782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT89"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT89"/>
    <dbReference type="GeneID" id="33559591"/>
    <dbReference type="InParanoid" id="A0A1Y1UT89"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="269"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="451" mass="50945" checksum="A67E562BBCFAE963" modified="2017-08-30" version="1">MPMVVLLAIFSSMRYGVHDVITSPKSYILPSSFTTPAPPKSHNYISTRAADLPQTELVAGVAGFNYFRNLYYFGSTFYVVTDEVEEMKKIEYTYVITGLKKEDAEGKSVEIPVEETWQVISFEEAEELFKPVVVRKNGLTLFYADATSPNFLGHYFHLVAEMFLGAMRVQAADGEYELPARTIYRGTAASRRDRYALNEWFNEIAMPNTALEDQSVLQDRTHSGIPYVYERIVIADRWAAHKHGKNPRRWNKVTGDVPDVQVPADWFRPVRNSIKLAVLASGCDIRRKDPSVPVVLYVNRQDTGRRLLAEDAESLAFELDALHQQGLIELHDVQMGKVSKLEQFCLACKADVMLGVHGNGLTHQMWMKPGSAVLEMMTVGGHARDYNLLADMVGHQYETIHNNHTFPREKWGSVGQGKNFHSSSIRADGKFVAELVLQKAQERIKNIEPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTD9</accession>
    <name>A0A1Y1UTD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_575284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874972.1">
        <property type="nucleotide sequence ID" value="XM_022013120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTD9"/>
    <dbReference type="FunCoup" id="A0A1Y1UTD9">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTD9"/>
    <dbReference type="GeneID" id="33554928"/>
    <dbReference type="InParanoid" id="A0A1Y1UTD9"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="213" mass="24153" checksum="A00354CE9D222C50" modified="2017-08-30" version="1">MQSITRWINGPTPEEKVRAWKSKLRQEERGLDREIANLDRATAKSKAELKALAKRNDAKSARILAKELVRAKHQRDRLISSKARMGSIQMQLQHQLSMVKVTGAFQKSSEIMKTTNQLVKLPQLSATMREMSMEMTKSGIMSEMMEETLDTIDDDEIEEEADAEVEKVLFELTDGKLGQAGKVGGELPVKEEDEQEAAEMQKMQREMQDLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE0</accession>
    <name>A0A1Y1UTE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_54688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874960.1">
        <property type="nucleotide sequence ID" value="XM_022013013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTE0"/>
    <dbReference type="GeneID" id="33554821"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE0"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="99"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX41281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="45469" checksum="0A17F49A1BC0C7A1" modified="2017-08-30" version="1">MRLLLSHRAEDNPISSSPHFAAIITASLVWVFYAWATRLLRGTPGHAFTNLAFLVCALLCSASFYKAIRTDPGFVPKPSGGSDVKMMLEDLVDAGRLNGTNFCISCMTKKPLRSKHCRVCKRCTARYDHHCPWIWNCVGFRNHRYFLSFVLFLIAGIILFDRLTIDYVLENAPAYSPSPSPGLTVCDLSETLCRAGSYDAFLSAVAFWATLQLTWTLILGVSQLWQVSRQMTTLEVSNLGRYGYMGGRGGQSLRDQSGAMRQAAAVGAGVGPMGASENAPPESGIAGPDGNLIAARGPAKHSHGPHGHAHSHGSFPVRCCGALWKGISGPMMQVLGLDRFTKGKALGGMRKAGRDQNPFDMGIIQNCSDFWLHPNDIDYTQVYEIPAEGWKSYRRRAKMSTGVGAKGAYEPVSGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUC5</accession>
    <name>A0A1Y1UUC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 60s ribosomal protein l7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_613009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874725.1">
        <property type="nucleotide sequence ID" value="XM_022014462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUC5"/>
    <dbReference type="FunCoup" id="A0A1Y1UUC5">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUC5"/>
    <dbReference type="GeneID" id="33556270"/>
    <dbReference type="InParanoid" id="A0A1Y1UUC5"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX41046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="250" mass="28557" checksum="756A0867B81E9220" modified="2017-08-30" version="1">MAPSTSVPSADHVAVPETLLKKRRTTEASREAKLAAAQEARKNQKAKRKVIFKRADEYVKEYIAQEKEEVRLKRAARSTGDFYVEAQSKVYFVVRLKGVSKLAPKPRKILQLLRLLQINNGVFIRVTKATKNMLQLVEPYVTYGEPNLKAIRELIYKRGYAKVHGQRIPITDNAIIEKQLGKYNILCMEDLVHEIATCGPNFKQATSFLWAFKLSNPTGGWRPRKFITYVEGGDTGNREKHMSKLIHQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUC8</accession>
    <name>A0A1Y1UUC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_21530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874474.1">
        <property type="nucleotide sequence ID" value="XM_022012197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUC8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUC8"/>
    <dbReference type="GeneID" id="33554005"/>
    <dbReference type="InParanoid" id="A0A1Y1UUC8"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="128" mass="14694" checksum="2DBA421844A415FF" modified="2017-08-30" version="1">MTVKVIRIALLICDTPLPRVMKDHGDYLQIYRTWLLDSLATYSDQEIAQDTELILDGYNVVDHGQFPPRERLIAGARDAYDAVMLTGSSEYSALHCIYGRCIGFYSRPTLCRELLLNTSRIPFRTYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUN0</accession>
    <name>A0A1Y1UUN0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HRDC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_27104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874584.1">
        <property type="nucleotide sequence ID" value="XM_022012339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUN0"/>
    <dbReference type="FunCoup" id="A0A1Y1UUN0">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUN0"/>
    <dbReference type="GeneID" id="33554147"/>
    <dbReference type="InParanoid" id="A0A1Y1UUN0"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="40"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="163" mass="17851" checksum="C3AEE317A86B2B0F" modified="2017-08-30" version="1">MNGTARTANGVGGPMHQYGGPSKRTKAVAVEEDATKLQFGDFADGEALTPMDVKTVLEAVRSAPGAPPAPDNKVYKAASEYINQFSNASTEMVESMRTALSARPGFLNKFEIAQIMYLRPSTLIEAVTLIPSLERYHNGDEDQRILEQLLEDIKLMARYNSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6F1</accession>
    <name>A0A1Y1U6F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminopimelate epimerase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867928.1">
        <property type="nucleotide sequence ID" value="XM_022017238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6F1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6F1"/>
    <dbReference type="GeneID" id="33559047"/>
    <dbReference type="InParanoid" id="A0A1Y1U6F1"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34559" checksum="5CA3CC7422EAAFE0" modified="2017-08-30" version="1">MPPVKYELIHAFVPSGSNPSLSGNPAAVLQLSRSNDPSCSLASAIPTSQGSLKSLFPPDEHLHNIAKELDLPMTSFVIPLNAPNTFALRWFYSGGEAPMCGHGTVAAAHQLLSQGTKSPITLHTVNAVLQAEQTVNGIKIQLPADTQFDDAPQDTEHIMKKIFNGGDVKPRKVSVIGAYSMIELDSEVDMQNLKIDFEALKQAKTPTPNLRIFQIAPPPSSETGPHLRSRVFNYYPSGEFAEDAATGSAHAAIIPLVLTSRLSALISCHPDLKSQDPVRVLRIRQCSERGGEMVATWDDEAGVVMLEGNAIHISQGEVNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7D5</accession>
    <name>A0A1Y1U7D5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_184393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868229.1">
        <property type="nucleotide sequence ID" value="XM_022012121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7D5"/>
    <dbReference type="GeneID" id="33553929"/>
    <dbReference type="InParanoid" id="A0A1Y1U7D5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="339" mass="36935" checksum="761854480B1D30F6" modified="2017-08-30" version="1">MRSPTVAELIRLANDSERQDYLEGRWDVCQTLKDPFLGTTGASSRVDLSQATWAVDFLVEEAQEALRKQSIGLSRQLTTALKEKDYGEAARLSGWLATDLALDTGTDKRPSSSCEDNSDTGRGTATPTEASGPKNENEGDNNETTQNYPHKQYLITHPSFEPRSLFALDDPSVQRPDINRGEIVTELGGQWGKGFTSSGISMTSKGNGAESFLVSEGQPDEYWSIRPTSVNELDAGYTGDDRPPAPSYRPGEWVSGRNDDELTYVRVESDGTVGSRPDNHPLGPRTGESSSRLAPFAALGLGDLLPDTKRTAATTRSGRGDAFHSSRIPSKPNRSEYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7S7</accession>
    <name>A0A1Y1U7S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_639391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867895.1">
        <property type="nucleotide sequence ID" value="XM_022017226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7S7"/>
    <dbReference type="GeneID" id="33559035"/>
    <dbReference type="InParanoid" id="A0A1Y1U7S7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="63" mass="7149" checksum="A7E2A9B0843107C4" modified="2017-08-30" version="1" fragment="single">MAMRLDSGESQRGRRAVRQLEFTDCTGQGGGKRRDDGTSFFFWEERTTQTNGFARIVCTPSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7U1</accession>
    <name>A0A1Y1U7U1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="3">1.1.1.271</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867905.1">
        <property type="nucleotide sequence ID" value="XM_022013712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7U1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7U1"/>
    <dbReference type="GeneID" id="33555520"/>
    <dbReference type="InParanoid" id="A0A1Y1U7U1"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="332" mass="37421" checksum="60266B023C8098DB" modified="2017-08-30" version="1" fragment="single">LKTESTVRAGSGLVGSAIRHVISTEPEGSTFGQRPDEEWIFLSSKECDLRDFNATTKLFEKYRPTHVIHLAALVGGLFANMSRKLTFLRDNLLINDSVLQNSHDFKVQKLISCLSTCVFPDKVEYPLRESSIHLGPPHQSNFGYAHGKRLVDIQNHAYHEQYGDMFTSVIPTNVFGPGDNYDLEQAHVIPSLIHRCYKAEKENKPFVIAGTGKPLRQFIYSRDLAKLIIWTLRYYEEIDPIILSVPETDEISIKGVGDAIVKHVGYKGEYTYDTTKSDGQYRKPASNDKLMNCMRASGLDFSFTPFDDALSASVKWFVDNYENGARIGLPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U865</accession>
    <name>A0A1Y1U865_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1688-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_639192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868007.1">
        <property type="nucleotide sequence ID" value="XM_022017201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U865"/>
    <dbReference type="STRING" id="4999.A0A1Y1U865"/>
    <dbReference type="GeneID" id="33559010"/>
    <dbReference type="InParanoid" id="A0A1Y1U865"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47594" checksum="2BF3F0008D804272" modified="2017-08-30" version="1">MAEAIPDIVTYLRSLDAVHDRCNQVFALAEVGQVDHWTFHQDKVADVVDYCVTLITRDYGDLSKVPPTSRRTHFEPPTKAQDARMGRIPALLLLCPKDPIAKTLTLIDLYVVSVLLDAGAGPDWVYTEVGPDGRETWKGGRSEGLAVASYQMFTAGVFSSNNANKLQVDAKALKGLRVETLAKHLQVSDSNPMAGLEGRCELLIKLGSALGDRPDICPSGRPGEIINYLEGRLPSADTLPLSLLWSTLFELLLPIWPSRTTLPDHPSFPLGDVWPCPSLERSLTGDRTTGDNLVAFHKLTQWLCYSLVEVIESEGGWKVDRGRGQTALPEYRNGGLLVDLGALTIKPETLPPDAYPRGRDQPPLLAPSHPAIVEWRALTIGVLNHCHPLICEKLGTQLSLAQVIEAATWKGGREIAKTKRQGGGPPIDIISDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8D3</accession>
    <name>A0A1Y1U8D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_583844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868578.1">
        <property type="nucleotide sequence ID" value="XM_022013642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8D3"/>
    <dbReference type="FunCoup" id="A0A1Y1U8D3">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8D3"/>
    <dbReference type="GeneID" id="33555450"/>
    <dbReference type="InParanoid" id="A0A1Y1U8D3"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="311"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="43564" checksum="F02FFA7FD7C4941B" modified="2017-08-30" version="1">MPPKKKNEETKKIMLGRPGNNLKVRIVGLPNVGKSSFFNTLSQTDLGKAANFPYATIDPEEARIPLPDERFNWLCELYKPASKVPAFLTCIDIAGLTAGASTGAGLGNAFLSHVRAVDGIFQVVRAFDDAEVIHVEGDVDPLRDMHIISTELRLKDIEWVEKDLERLKKGAKALGTSSLAAKARAEETATVEKILALLADGKDVRKGNWNNKEVEIINGLNLLTAKPITYLVNLSEKDFVRKKNKWLAKIKGWIDENNPGDALIPFSVALEERLVDMSDEEKIAEAEKLGLPKGNPSALGKITTAGYTSLDLIRYFTCGPDEVRAWTVRKGIKAPQAAGVIHSDFENKFVCGEIMSYEDLKEHGSEAQVKAAGKLRQQGKPYEIVDGDICYWKCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8D5</accession>
    <name>A0A1Y1U8D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_643770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868103.1">
        <property type="nucleotide sequence ID" value="XM_022017568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8D5"/>
    <dbReference type="FunCoup" id="A0A1Y1U8D5">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8D5"/>
    <dbReference type="GeneID" id="33559377"/>
    <dbReference type="InParanoid" id="A0A1Y1U8D5"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="354"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="629" mass="68882" checksum="1B9EB7466F9EC067" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8R6</accession>
    <name>A0A1Y1U8R6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-repetitive/WGA-negative nucleoporin C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_583498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868671.1">
        <property type="nucleotide sequence ID" value="XM_022013626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8R6"/>
    <dbReference type="FunCoup" id="A0A1Y1U8R6">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8R6"/>
    <dbReference type="GeneID" id="33555434"/>
    <dbReference type="InParanoid" id="A0A1Y1U8R6"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="112"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="601"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1263" mass="140963" checksum="A4F78600AFA10A07" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8V8</accession>
    <name>A0A1Y1U8V8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_636095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868742.1">
        <property type="nucleotide sequence ID" value="XM_022016866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8V8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8V8"/>
    <dbReference type="GeneID" id="33558675"/>
    <dbReference type="InParanoid" id="A0A1Y1U8V8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="89"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="673" mass="72384" checksum="744E79058F47191D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U900</accession>
    <name>A0A1Y1U900_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_604668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868745.1">
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    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1U900"/>
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    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="197"/>
        </location>
    </feature>
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        <location>
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            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="766" mass="82381" checksum="3A4763FC79F2622E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U943</accession>
    <name>A0A1Y1U943_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome c oxidase subunit V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_636345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868811.1">
        <property type="nucleotide sequence ID" value="XM_022016887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U943"/>
    <dbReference type="FunCoup" id="A0A1Y1U943">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U943"/>
    <dbReference type="GeneID" id="33558696"/>
    <dbReference type="InParanoid" id="A0A1Y1U943"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="175" mass="19300" checksum="9BE39E3181CB11C8" modified="2017-08-30" version="1">MSPLSSSLRQAVATASRASTRTTLRSYASPAISVTSTRSNTSAPSLANIEATWTHLPKEERYEVYKQLHDLQKKDWKELSRDEKRAAYYIAFGPHGPRKPIHGDGYGMQVALGTAGIVGASVLAFLTVRHFGQPLPETMTKEYQEQSNEYMRSQNMNPISGVSSEGYKGKGMVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U970</accession>
    <name>A0A1Y1U970_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_658098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868345.1">
        <property type="nucleotide sequence ID" value="XM_022018875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U970"/>
    <dbReference type="GeneID" id="33560684"/>
    <dbReference type="InParanoid" id="A0A1Y1U970"/>
    <dbReference type="OrthoDB" id="2596696at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="51528" checksum="4168E43C9D7F17EC" modified="2017-08-30" version="1">MGGNALGRQANRMSLPQHRAFSTYCQERLEPFFKGIYKWKDLKDKESHGDLDLVCAWDEYDPTAHVKGYEEDLRFTHQVQERKGIPSASNASPNSGLSVAGDGATVQAPGGKATWSKGLALHPDNLKFRAWVSDLAKALNASAWARNGIKTPIISFAVLCEDLPFEEAQDVQPTEEQKAAGHEPFWQVDCITVPSSTASFALLSTSYGDSLVVLSYALKILCPSFSLSSTQFNLKHSPFSGIPPIQVQLTTDPVPFCKWLGVDYDKWQATTFADNHELWEWLTNVEPSSILGTIWIKLAAPRKEDHDKDFETGDGTPVIRNHVRKISGVAKFLKWLRRPDSHWVKLAVECEAAKLGESTINPSSCDDTARSVASAEPSPISTSVEQLILDPGSPSPLDNHARDALTFWDCQSEYNVQYADRQGQARLLAERRQKHLENKAKQEAQLASLAQGVDQLKIVNSQVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U977</accession>
    <name>A0A1Y1U977_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867955.1">
        <property type="nucleotide sequence ID" value="XM_022017184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U977"/>
    <dbReference type="STRING" id="4999.A0A1Y1U977"/>
    <dbReference type="GeneID" id="33558993"/>
    <dbReference type="InParanoid" id="A0A1Y1U977"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37185" checksum="4B22F3CEE15172EB" modified="2017-08-30" version="1">MLDTSGSIVVTGPQGGMTLHFIESYYQKHPDNHLVLLVRDPSKVLPSLSTMSNCTILRCDLSDLSSVRQASQEITDRVKSGKLSPIECLVESAAVQVCGPNGPRITQDGYEETVAVNHLAHFILTLDLLPSMKPQGRIVIVGSDSHRPNYKFIKIGPKYKPIESLLKVEPGTDPSGSGVDIGMARYSTSKLLQMMTGHELARRLKTSSKYKGIHVVMFNPGSMGGTGLFRDRSWIGRVILGYVLNWTRLLNWLDPALMASRKEDSAAVLERLVEDPSYALTEPIDEEGQTISGVGAGAPYFDYAGNQASTLGEANEQEKCEELWRDSATLLGYSGEKALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U990</accession>
    <name>A0A1Y1U990_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_162043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868861.1">
        <property type="nucleotide sequence ID" value="XM_022012063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U990"/>
    <dbReference type="GeneID" id="33553871"/>
    <dbReference type="InParanoid" id="A0A1Y1U990"/>
    <dbReference type="OrthoDB" id="2573713at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="63" mass="6699" checksum="5F108393C828B523" modified="2017-08-30" version="1">MGLPHPLGTPLAWGSGMGIDNTAAAWRRYCGLGGFLTGYPVHTRLPGRPGLGGYWGVSRLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9B0</accession>
    <name>A0A1Y1U9B0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_636765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868412.1">
        <property type="nucleotide sequence ID" value="XM_022016933.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9B0"/>
    <dbReference type="GeneID" id="33558742"/>
    <dbReference type="InParanoid" id="A0A1Y1U9B0"/>
    <dbReference type="OrthoDB" id="2575475at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1361" mass="149888" checksum="9C8C83C123FDD159" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9F4</accession>
    <name>A0A1Y1U9F4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868903.1">
        <property type="nucleotide sequence ID" value="XM_022018579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9F4"/>
    <dbReference type="GeneID" id="33560388"/>
    <dbReference type="InParanoid" id="A0A1Y1U9F4"/>
    <dbReference type="OrthoDB" id="10478430at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="451" mass="49437" checksum="D774A147085B58FE" modified="2017-08-30" version="1">MAARIHQVDVPRAPLLLEEDGQPLKIYIHPDVPMRHLFISQVEAQCIAAVPGDATHILLDLLPPHKGCSSHPTQDQMGFIFHREARHVLCGYWAQECLRVGGVADMTFWDLSGWHEWQALDHKPGSSTGSTLKASSGPGKKGGPAARKRKRVSTVKTTSMGEEEASLKDVSEGSSYQAAASLASSASVASESLRQVEGSGSSLKAGAYRPRRAIVSVELVASARKKKASINPPNPRAGPETIRADTVESSGSSSIRSIPTSSVSQLASSKQVARQKLQESSRQKLQESSPTPQRTGKYNPSKLGEKSADEIQNMWTFFLDHIHARMGIPSPSDAVMGNLDTVKQCMLTRVHGMWCEARSKYPGRPLDPLSVMISTWKTSREFNLSPFAIRKYYDDFQGRVNADKVQNIPLKNRPPGYPFHDRPPVNPEAALSSIPEWTGKYNIVVKQELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9U8</accession>
    <name>A0A1Y1U9U8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868154.1">
        <property type="nucleotide sequence ID" value="XM_022017167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9U8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9U8"/>
    <dbReference type="GeneID" id="33558976"/>
    <dbReference type="InParanoid" id="A0A1Y1U9U8"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="28872" checksum="E0EF7F00DAB649DF" modified="2017-08-30" version="1">MARGSDPFFSTAGEAGPSRRSSHIQRAQRERPPGRTERVGARSATPAYSSRGRNRKGYKGKAGTAADGAKAGSEHRKKRSSAFNVGPAHAPKNAYLGKAKKIKADLIMKSKIKREYAKVLKAEGMESDRLKPRGRKGESQSTADPPKNPPVLPSQSPPLLPGSSPTLDEAAFPAPGRPSQRQRATQKPLADKTRALRPQDIGHPMPQTSLRELKKEAYSKFHRPANRSGATPTGAGVMGHGRRGGSQPNLGARMGVLLEKIKRDKAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9W5</accession>
    <name>A0A1Y1U9W5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_635163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869061.1">
        <property type="nucleotide sequence ID" value="XM_022016791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9W5"/>
    <dbReference type="FunCoup" id="A0A1Y1U9W5">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9W5"/>
    <dbReference type="GeneID" id="33558600"/>
    <dbReference type="InParanoid" id="A0A1Y1U9W5"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="103"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="43361" checksum="DFAC44E2843926EF" modified="2017-08-30" version="1">MPKLKSALANHQAHQARLNAQAKSSQVNHDKERSIKYGKSKKAKTKVGGGVGQKATTYGDTGQIGQMAGPSGSIHGINPTSLTKGKGKARAPTNPIDKDDTVLLLGEANFSFALSLVSSPHSHPPTLVCATSYDSEKTCYQKYPDAAGHVDKLRALGVNVGFDVDAGALEKSKSVVGKGRRWSRIIFNFPHVGAGITDQDRNILSNQHLLLRTFRSVAPFLSKGPSKFPLVNEQRMKKRKRTQAEDDVSDVEGTIEDVSENENENEDAHDDPSDGQEPSSLPRTTARTIPFTTPKKQGTILITVLNQPPYTLWNLSKLGTKPPPLCPGTTLPQPRYTLLRSFAFAPELWRGYEHRRTLGFKEGLSKRENMEIIGRKGEARTWEFALKADEGEEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA85</accession>
    <name>A0A1Y1UA85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_635887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868690.1">
        <property type="nucleotide sequence ID" value="XM_022016844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA85"/>
    <dbReference type="GeneID" id="33558653"/>
    <dbReference type="InParanoid" id="A0A1Y1UA85"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="149" mass="17049" checksum="FC3884307B38C1CB" modified="2017-08-30" version="1">MSNMASHSARSKGSENPFSAVTNLPPSSSPESDEAFSTMKKSALYKRLLAKYGTEKHSKLSELEHAWTHHVQYQKRMSEDISAVLSVLNDYDDDQMTAENMERGLEFRGWTRVEHCTSCEEEATREEEEAKKKEVDELSEMVSMHIQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAD8</accession>
    <name>A0A1Y1UAD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868777.1">
        <property type="nucleotide sequence ID" value="XM_022016877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAD8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAD8"/>
    <dbReference type="GeneID" id="33558686"/>
    <dbReference type="InParanoid" id="A0A1Y1UAD8"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="405" mass="45747" checksum="9DA0BCB28FA9534C" modified="2017-08-30" version="1">MFGMLQPTRLSPLRRLGVRYVNDLTVQRGRHGSTPMIQHGPPGRSAVSGHTVTVFGCTGFLGKYVVQQIARKGTQVVVPYRDEDEKRPLRVMGDLGQIVPLEWDAKNLDQIRECVRRSDTVYNLVGRDYETRNFSYRNVNATVAGNIARICREEGVPRLIHVSHLNASADSPSAFYRTKHNGEEIVRREFPEATIVRPGPMYGHEDWFLNDMAQWPIKYALNGSRTRTMPVHVVDVAEALSKMLDAPKTSIGSTFVLPGPEVFTYDELLNLVSFFTMRPRRSLPPIPGFVASMFASVVNRLLWFPTVAPDEITRKFIDDAGAKLDQAIAALKAKNYPEGWSKDFDTATYDVNGRLVKSWADLDIQPARLQDHAVKYLRIYRSSENAETPLEVGSFKPPRPYKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAE1</accession>
    <name>A0A1Y1UAE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_582450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869198.1">
        <property type="nucleotide sequence ID" value="XM_022013558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAE1"/>
    <dbReference type="GeneID" id="33555366"/>
    <dbReference type="InParanoid" id="A0A1Y1UAE1"/>
    <dbReference type="OrthoDB" id="3360632at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF695">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="65907" checksum="1FDFAA26C706B562" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAT9</accession>
    <name>A0A1Y1UAT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_652870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869374.1">
        <property type="nucleotide sequence ID" value="XM_022018569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAT9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAT9"/>
    <dbReference type="GeneID" id="33560378"/>
    <dbReference type="InParanoid" id="A0A1Y1UAT9"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="303" mass="33219" checksum="B828EA954CD0F368" modified="2017-08-30" version="1">MDVSQDLADYAAKHSSNLLARPQPADVDLGYLAAFDTTPTDAELYSSSRDSHLRDLALASVSTLLNSLFALPKTSSPLGPVVRPPAPTTVLPREKPLPKPKPPTKWERFAKEKGISHVKKDKVVWDEEKQDWVKRWGRGGKNKEAEDQWLHEVKGGDNADHDPAATARAERKARIAKNTAQQNANLASASSSKEARKAELNRSMLISKTSTASLGKFDKKIEGEPKARGVKRKFDGVVEHDWKDEKAKALDVLRGVESGEKRKVKGTAREEGAVNVRKAVRGLGRDGPGNDRGVKGKGKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAW6</accession>
    <name>A0A1Y1UAW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_634036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869358.1">
        <property type="nucleotide sequence ID" value="XM_022016694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAW6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAW6"/>
    <dbReference type="GeneID" id="33558503"/>
    <dbReference type="InParanoid" id="A0A1Y1UAW6"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="748" mass="83606" checksum="21EE43172AE95D41" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAY9</accession>
    <name>A0A1Y1UAY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_127013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868929.1">
        <property type="nucleotide sequence ID" value="XM_022011975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAY9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAY9"/>
    <dbReference type="GeneID" id="33553783"/>
    <dbReference type="InParanoid" id="A0A1Y1UAY9"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="421" mass="46730" checksum="4DA90B8BE54AC673" modified="2017-08-30" version="1">MSESHDGSDSVHGLGPGPSDLRQLLGRPLAITIHDGRMFIGYFHCTDRDMNIILNDTEEFQPAPRTKAEVLQRDREEIWLPRSERLEGEPDWSFWANLENFGPAVTSGEEAKGVQGENSGSERGDTEQSLGSSNDVQEMVAALEDTRVDGQGSERRSKETETTSLALKDDSTISDIQQAVNLKTVSTTDAAHQPHESSNTPSSCFTHSSESDSSSNWMQTLQGWTWGFRRGPGRFTGMIMIRGKDIIKIELVHGSFHRIQSTIGLGSRPHSHMQNKRRRFWLALAQVMHYSPRGFSRRARLCTTDVCPLRLAMNGKTLSFQTQSSKLSHASSILTILGSLSNEAWSSGYKTRRLQRRIGTFCTLVLHHSPHLNELTKPSSESSAMSSSGICKVVNDIDVPHAAYVDSSVNHSSWNNTSCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB58</accession>
    <name>A0A1Y1UB58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_86557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869463.1">
        <property type="nucleotide sequence ID" value="XM_022019268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB58"/>
    <dbReference type="FunCoup" id="A0A1Y1UB58">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB58"/>
    <dbReference type="GeneID" id="33561077"/>
    <dbReference type="InParanoid" id="A0A1Y1UB58"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="486" mass="52572" checksum="57D9C61438AB2CF7" modified="2017-08-30" version="1">MPSFVKRTTASSNAPPAGTTPALSTSIPPLYLAPTGIPSLDDIFGGGMPLGNVWMVLTPDRHTNWSRIVERYWTARGLVDGQKGLVVGEKGEDIVRGCMWLDEARSESSARAGSESEGEEAGLKDVSALGENRPKIAWRYDGMKKFETGIGKGDRGELNLLKTIPQSTISSMEKQKIQRYIPLDPPNNIAGSSSLAWSIMSSVLSQIQALLHTHNDSQVLRITVHNLGDIFWGSPSSAQILRFIHSLRSMVRDRSASVLVAMPADLSRSPPTSARREGSDESASSSREWIKQLAWSVDACIELKGFGDDPTLPPVFHPLHGLLTVHSLPTTHHVLPPSYKHSSLLGLSTSTSTAGRGGGAGENNLGFRLGRKRFSVETVHLGIEGGQGERRTEPVPDTSLLSAGIERPAQQTSHETKLQSGQVDITTPGQKPSMSVPPDVSGKSDISGVKKRVKGVRFSAADDTPRDDGPEGRVKIRHDQMDLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB76</accession>
    <name>A0A1Y1UB76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_632111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869459.1">
        <property type="nucleotide sequence ID" value="XM_022016490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB76"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB76"/>
    <dbReference type="GeneID" id="33558299"/>
    <dbReference type="InParanoid" id="A0A1Y1UB76"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="174"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="771" mass="84589" checksum="DEE6003D3A395E98" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBE3</accession>
    <name>A0A1Y1UBE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-alcohol phosphatidyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_632334</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869512.1">
        <property type="nucleotide sequence ID" value="XM_022016514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBE3"/>
    <dbReference type="FunCoup" id="A0A1Y1UBE3">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBE3"/>
    <dbReference type="GeneID" id="33558323"/>
    <dbReference type="InParanoid" id="A0A1Y1UBE3"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="317" mass="35359" checksum="456AC6CC398A8575" modified="2017-08-30" version="1">MAPTTRSKQSTPERQNAGSSSSTSTAVKSQTLDGEKGLRVREGSRARQEDVVDPNYALGLANRSHENVYLFVPNVIGYIRVVTAAASLYIMPTHPKVCTFIYFISCILDVFDGMAARKLGQESKFGAVLDMVTDRCATACLLCFLSATYTNHSLLIMFLITLDFSSHYIHMYSSLVTGSSSHKAVTSDVSRILWYYYHNRNVLFTVCFANEVCFVCAYLAFYEKTPIHSSVLIKYLSHLLPVRQILYHTPAPLDYLLETLGNVTWAQLVFWLTAPVCALKQVINVVQFWKASKILVGVDLAERQAAREAAARAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC13</accession>
    <name>A0A1Y1UC13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_113749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869242.1">
        <property type="nucleotide sequence ID" value="XM_022011939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33553747"/>
    <dbReference type="InParanoid" id="A0A1Y1UC13"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151747" checksum="74812E369811950F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCU9</accession>
    <name>A0A1Y1UCU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_629317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869997.1">
        <property type="nucleotide sequence ID" value="XM_022016195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCU9"/>
    <dbReference type="FunCoup" id="A0A1Y1UCU9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCU9"/>
    <dbReference type="GeneID" id="33558004"/>
    <dbReference type="InParanoid" id="A0A1Y1UCU9"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012643667" description="HCP-like protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="89989" checksum="038E64462AFD8A65" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCV2</accession>
    <name>A0A1Y1UCV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leo1-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_657347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869544.1">
        <property type="nucleotide sequence ID" value="XM_022018864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCV2"/>
    <dbReference type="FunCoup" id="A0A1Y1UCV2">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCV2"/>
    <dbReference type="GeneID" id="33560673"/>
    <dbReference type="InParanoid" id="A0A1Y1UCV2"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="498" mass="54664" checksum="D8BB6F970C5469EE" modified="2017-08-30" version="1">MSEGELAEDLFPASGSGSPAKSIGEDAPVASGSRSQSPAQPTLENPVEEPVDDDDDGDLFGDDDEEDAKKSASPRSRAASSSATPKTPPTSASEDGGEGSAHGSPNPLEYAEEEVGVEQDVIWANIALPKMPRLKATDGKIWQLRLPAYVNIEPKPYDAHYYQETLNESEIDGSKDPMGAKSRMLGVKNTIRWRWVMGPEGKPVRKSNARMLRWSDGSMSLQLGSNLFDVAASHGATLQRDEDIKDVKPSTTSQPEASTSQTNATFLCVAVGSERVLMTEGPIAGQLSLVPTSMTSATHLELAKHVGQQHVKHSRMKILEDEVKPETLANLQREAAGKSVVTKLRVKRPTGSRGESSRRNQRGRRARSESSGSERGFRREKDYEEDDGFVVADDDDEEEAEETEDEDDAAWGSKKSKSKSSKRAKRRKGSESLDELEEADRRLEERERERKRAKKAKAKSRDYVDSDEDDEDEVDDADEMEGGDDDADMAMDVESEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD40</accession>
    <name>A0A1Y1UD40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869626.1">
        <property type="nucleotide sequence ID" value="XM_022018516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD40"/>
    <dbReference type="GeneID" id="33560325"/>
    <dbReference type="InParanoid" id="A0A1Y1UD40"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="32372" checksum="7979DD8F90128851" modified="2017-08-30" version="1">MPLFTSLRAPISPVIKPQHLESYFSLVQAITMANSQASADSWEEDFKAWQSDRRSGKVKARNESRDERVRRLLLYSQTEGLPHAPEPPLPSSGSHDNEPFFTKWHPWEGSDSRKDRKYATSETVRHPEHREGYVGDTNRDWESDLDRDFEWGQKSGGSLEDDLQAMDISNGRELSESMSKGKQKDMHWRSCEGPDEDLMDISDLEKIADSRDSEAELRVRAWEELASMGLRKPLRIRRSPQEPESTWFGSDSSANSEQGESRRSGSSRPGYRPSRLSNVETVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD59</accession>
    <name>A0A1Y1UD59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_629685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870092.1">
        <property type="nucleotide sequence ID" value="XM_022016241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD59"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD59"/>
    <dbReference type="GeneID" id="33558050"/>
    <dbReference type="InParanoid" id="A0A1Y1UD59"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="397" mass="42575" checksum="EF3806EAA967074E" modified="2017-08-30" version="1">MQLNGSKAPGNFSEKDQGKKKPFAKLRAAWGDNNLSPRMLKFKNHFIAMVGEYVGTVLFMIFALGGTNVANMPSTNVTGQTTSGQNGSEATAANTSNLLYIALSFGFSLAVNAWIFFRVSGGLFNPAVSLGMALVGALTPFRAALLTFAQILGGITGSAIIQALTPGTLNVRTQLADSVSVARGLFIEMFLTSLLMIAILLLAAEKHKATFIAPIGIGLALFVAELFGVYYTGGSLNPARSFGPSVVLRDFDSYSWIYWLGPALGATIAAGFYKMLKVLQYETVLGPEDGDNNEEVAGFQDTSVETGDENESNDARSAEEGRSRVMSSDTDRTLAHNSLDGKLSPHSSNDSTTNNKKGPNEPRRMEERLDRIEELLARLVESRPSPNSTPQGGRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDE5</accession>
    <name>A0A1Y1UDE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_59611</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869708.1">
        <property type="nucleotide sequence ID" value="XM_022013857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDE5"/>
    <dbReference type="FunCoup" id="A0A1Y1UDE5">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDE5"/>
    <dbReference type="GeneID" id="33555665"/>
    <dbReference type="InParanoid" id="A0A1Y1UDE5"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="308"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="46746" checksum="EF31CE08DF2A744D" modified="2017-08-30" version="1">MSKSKSIASTFTPLSLLTLPDKKALQDEFVGRDISSLRTPALILDRTKFKQNCERVTSEAKRRDLRFRAHVKTHKTSEGVRLQVQAGGGVRALVCSTMPEVWQVVASGVVHDGLVDDILYSLPIGEDKLEDLNDVQEKVGNKAIVRLMIDHPAQVEAIQRFSERFGRNKPWSVFIKVDGGGKRAGLPPQSQQMKELVEAVLACSAVSIFGFYSHFGQSYASKSLDNASDYFKGEIECVNSAAQVARSLGAKGDWILSVGATPTAHAAVQETHQAMQGLEGALELHAGNYCVCDLQQYATSLVAPTDLALTVIARVVSLYPHRNEAMCDCGALAVSKDTGPFEGFGHVISPPHATAWDLGRISQEHGTLTHRPKSSKVGDTSEQPGQLNVGDVVRIVPQHACLVCAGHPWIYVVEDGGETVVDVWVPWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDF8</accession>
    <name>A0A1Y1UDF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_630031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870192.1">
        <property type="nucleotide sequence ID" value="XM_022016284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDF8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDF8"/>
    <dbReference type="GeneID" id="33558093"/>
    <dbReference type="InParanoid" id="A0A1Y1UDF8"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF20">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="55"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="380" mass="42952" checksum="9E357F712DCD4A1A" modified="2017-08-30" version="1">MPPIATQTVTSPTNEERNATLKLRGSSPPSEASSGRSRLTAPMQYQGLLDKYESFELTPSLGREFKDLQLTDLLKAPNSDALLADLAVLISRRGVVFLRDQNISSEDMMELSKRLADATQRPRESTLSIHPLESDTAPEIMVGGNPKTTDISASRQRKSGGISRFYDDVSRWASQAFHTDISFENVPADYSMLKINTLPPTGGDTMWINTYDLLDKMSPSFQEYLSTLEAEHSAEFFHDEARRLGIKIRPERERGHPLNKGDHLTAVHPVVRTNPVTGWRSIYLNKGFTKRILGVTKDEHDMIFDYINRAGFQNHDIQCRFRWGKGSVAIWDNRCTWHCATFDYEEERAGERASSIGEVPYFDPKSVNRKHGLAQEGKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UED4</accession>
    <name>A0A1Y1UED4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869625.1">
        <property type="nucleotide sequence ID" value="XM_022018515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UED4"/>
    <dbReference type="GeneID" id="33560324"/>
    <dbReference type="InParanoid" id="A0A1Y1UED4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="243" mass="27236" checksum="812A7FA759661DA4" modified="2017-08-30" version="1">MSDELGDANASSKLELHMRGLRLSDQTSQEESHRSFTDEERSEQSEVQSPTEGRLVDINMDVEDGDPLNVPVETTNEDIEASQHPPTPERWDPWAEADPCLGHTAISGNQTSQLQSRNDALSVRRLSNARLRSLQPLQGRGRVTKKSHLPRSHAHRRTSTRRGHNRSSTSSLEMSLREADAIWLTDNRTTSPVQEDLSEEHEPGTDGDQEDDSSTMNHQRDIRSSVQTPDSSKESSDAEHPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEI0</accession>
    <name>A0A1Y1UEI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_629508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870035.1">
        <property type="nucleotide sequence ID" value="XM_022016214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEI0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEI0"/>
    <dbReference type="GeneID" id="33558023"/>
    <dbReference type="InParanoid" id="A0A1Y1UEI0"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="360"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="508" mass="54708" checksum="A611AC8D5DEF1C76" modified="2017-08-30" version="1">MAVDSSPESSEIRTKQHHRIESEAHSLKRGRAESVEPPVLDRPETTSTGTKKNRLALSTGQAPSKPLDPDPSPNIDLDESDELEVADDAGAKDEAKNVGEVRRKVEKMTYEEGSKDASEAAAIIQEEDQELELPEKDEDEGPGSAMSTSTRFSKLDEKEGEGENGKAEPIDEEWQEIEKAEAEGAEAEAEALADGDVPTSMPMNKTSSSSGQEGLKRKVADRSESSYNINDTHAQVKRHKDTPSPSEEPPKVLPPVSEPLKKQSTFSSFASTSSPFASARTISPFGASSSASSSTPQPKPSAFKSSGFGNYSNASPFSKPPIKSTTTTEDKTASGDQSFENEPKASTFDDILKADAGTVTEEEKIRMSEQDVHTGEEDESPVHSVRAKLYVMQADGGWRERGVGTLKLNVRRSDGKGARLVMRAEGVLRLILNVSLYVGMSCLEDGKHVRTTVIEDGERKFLTFRTGSIKAASDLSSAIHDHIPLESGASASKSPELESKGRDAAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEI5</accession>
    <name>A0A1Y1UEI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869675.1">
        <property type="nucleotide sequence ID" value="XM_022018522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEI5"/>
    <dbReference type="GeneID" id="33560331"/>
    <dbReference type="InParanoid" id="A0A1Y1UEI5"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012982697" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48199" checksum="04195ED91D5DF8C4" modified="2017-08-30" version="1">MLSLFKLLFILSTGTITFASPSRRPVDPPLLKRDNINPSFSNPNAEPVGIVIDPTVQRDSCVTSPTLVNGRSFWLCRDTDKLTNEDITTINPFIVHSSAAWSNMTSSGPELLPIPPASQQGNTQLTYNYTSQLLQYPPGYTKGGYVPYVVGGDECSNTFGDPGTDCAPTTEVIIYPNSPAYPVASPSGSTFMALYEPIINTTNTANDNIECSLYFLGYNHSSNLTTLPTISLWKEAFFPKGAYCYGSYGGIVNEVDNYLYLYGQTYNRSSTALARVPLNEYLNINEYQYYYNNGTWSNVQPHVDDADANLNGQFVQPATPGVPAQGYGQGTFFYSDYVGRYVWLGQTHFEQWEPGVQVGVSTSANPYGPWTAAQNITLLPHGNPFGYSSVVHPEMSTNDQDVWLSYTAYVRLNDTNYYTQPLYKFEWSSSSASPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF69</accession>
    <name>A0A1Y1UF69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-cell immunomodulatory protein TIP C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_626704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870731.1">
        <property type="nucleotide sequence ID" value="XM_022015925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF69"/>
    <dbReference type="GeneID" id="33557734"/>
    <dbReference type="InParanoid" id="A0A1Y1UF69"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118725" description="T-cell immunomodulatory protein TIP C2 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="10">
        <location>
            <begin position="534"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="710" mass="76904" checksum="669A3EC7105A260D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF73</accession>
    <name>A0A1Y1UF73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_652063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870293.1">
        <property type="nucleotide sequence ID" value="XM_022018432.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF73"/>
    <dbReference type="GeneID" id="33560241"/>
    <dbReference type="InParanoid" id="A0A1Y1UF73"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="60"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1043"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1543"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1773"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1900"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="551"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1043"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1219"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1382"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1452"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1928"/>
            <end position="1944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1971" mass="204381" checksum="D4545C1B2AAABB4E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF74</accession>
    <name>A0A1Y1UF74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_626935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870790.1">
        <property type="nucleotide sequence ID" value="XM_022015947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF74"/>
    <dbReference type="FunCoup" id="A0A1Y1UF74">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF74"/>
    <dbReference type="GeneID" id="33557756"/>
    <dbReference type="InParanoid" id="A0A1Y1UF74"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX36721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="369" mass="39772" checksum="2D550A4976172EB3" modified="2017-08-30" version="1">MPSQNSPIKVGILGATGTVGQRFIQLLAVHPYFTIHALGASSRSAGHEYSKIVKWKLGTEIPEHVKGMVVQECRPDANGFAECGVVFSGLDHDVAGEIEFAFRAAELVVFSNAKNYRRDPVVPLMVPLVNPSHLSVVNHQRTTLSPPTKKGYIVTNANCSTTGLVVPLYALEKAFGPLETVMVTTMQAISGAGYPGVSSLDIMDNVVPYIGSEEEKIEWETSKILGGVTSDGQGFDLHASDPIKISASCNRVPVIDGHTGCVSVKFKRHPPPSPEQVIQAFKDFRCEAQDLGVPSAPKRAIVYLDAPDRPQPRLDRDLENGACVSVGRVRPCPVLDVKFVCLIDNVRLGAATSSIMNAEIAVERGYIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFH3</accession>
    <name>A0A1Y1UFH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_464506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870808.1">
        <property type="nucleotide sequence ID" value="XM_022012859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFH3"/>
    <dbReference type="GeneID" id="33554667"/>
    <dbReference type="InParanoid" id="A0A1Y1UFH3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="583" mass="63782" checksum="709AFD904E852174" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFI2</accession>
    <name>A0A1Y1UFI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_628177</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870388.1">
        <property type="nucleotide sequence ID" value="XM_022016094.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFI2"/>
    <dbReference type="GeneID" id="33557903"/>
    <dbReference type="InParanoid" id="A0A1Y1UFI2"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000307">
        <property type="entry name" value="Receptor-like histidine kinase BpdS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000079">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.240, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="719"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="1288"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1627"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1596"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
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            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="976"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1596"/>
            <end position="1616"/>
        </location>
    </feature>
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        <location>
            <position position="1067"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1775" mass="194529" checksum="394A05EF7F5D97BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFM7</accession>
    <name>A0A1Y1UFM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_474466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <end position="108"/>
        </location>
    </feature>
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            <end position="270"/>
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    </feature>
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        </location>
    </feature>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="393" mass="42377" checksum="002407DFCD31A070" modified="2017-08-30" version="1">MAVSPPTIDEQYSSLASPTREFREGPLPAFRARRVSMARSPPGPLVQDEEMGTGGGQSSRSMPRKKSQDVDQNYTRISASIRDSSNRLASLSFKPRASISSLTSGSNEAASISPYSLRFTHHHHSVSSGHSVPVHPLPGPSHLYETLLSPQSSGSGGVAQADGSPRLSRTSPKVPLEPINSEDVSPTQSQSGPSGLSRMMELEKARSAKIHSPIHEGVELPDDTTPRPSRGQSTVQLSAGAASPDQSNSPDDQLAMPTITDSGRKSNRTEMAPAIIVEPSEEEEQHAARTLQRYITKTLGEEDEENNDNSGSSENSPLLRRRSESLAHDKTHEHGSGSGRLGRTRWELNQRVRKMTWKGVLSACVADPLKTLPSVILGMLLNVLDGVSYGMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG62</accession>
    <name>A0A1Y1UG62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871071.1">
        <property type="nucleotide sequence ID" value="XM_022018181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG62"/>
    <dbReference type="GeneID" id="33559990"/>
    <dbReference type="InParanoid" id="A0A1Y1UG62"/>
    <dbReference type="OrthoDB" id="2574024at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="30142" checksum="EDDCC2EE4F0DFF3D" modified="2017-08-30" version="1">MLNVISTPPSRAPRLASLEPYQPRSGTTGVPSAIVSRRRVIGQLVPRAASPIIESSSSQDGDVTSKLDVLIGSIEGVLKGYAVYPSRSPTYFASLRDFHRRALELKAVPVDRDICQGPARTSLAQPEAHGREVDTDLGYHDESLGTANTAQKSSLHESVRSAPSRLPMHRSPSCNSLRPRPPRLPYLNETDPLSKDVRNLAHEWWNSEVAAAWYGPRPGVRSPPKSPVDRQRKKSLEDRGRFGTDGRDRRREEEREKSIKRDSSFVGLYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG63</accession>
    <name>A0A1Y1UG63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871038.1">
        <property type="nucleotide sequence ID" value="XM_022018338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG63"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG63"/>
    <dbReference type="GeneID" id="33560147"/>
    <dbReference type="InParanoid" id="A0A1Y1UG63"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="561" mass="61610" checksum="DDF27ECBBA02D153" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGG1</accession>
    <name>A0A1Y1UGG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">ITPase</shortName>
            <shortName evidence="10">Inosine triphosphatase</shortName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_455149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870665.1">
        <property type="nucleotide sequence ID" value="XM_022012827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGG1"/>
    <dbReference type="FunCoup" id="A0A1Y1UGG1">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGG1"/>
    <dbReference type="GeneID" id="33554635"/>
    <dbReference type="InParanoid" id="A0A1Y1UGG1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000009">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="201" mass="21627" checksum="B3DF78E92308ABA1" modified="2017-08-30" version="1">MPASSSKAPLVFVTGNKNKLKEVQQILASGTGELQITNQDVDAPEIQGNTQEVAIAKCRYAADKLGTACLTEDTALCFEALGGLPGPYIKDFLKTLGHEGLNTLLVGFSTTKATALCTFAYSSGPGQEPMIFEGRTEGQIVPARGPTHFGWDPIFQPDEGHGQTYAEMDGAEKNKISHRYRALEKLSAYLAEETKGEAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGN6</accession>
    <name>A0A1Y1UGN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871261.1">
        <property type="nucleotide sequence ID" value="XM_022018214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGN6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGN6"/>
    <dbReference type="GeneID" id="33560023"/>
    <dbReference type="InParanoid" id="A0A1Y1UGN6"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="419" mass="44286" checksum="C79EF392764A26C1" modified="2017-08-30" version="1">MATFTEHISAAAQMVNDPDVATELAFQLDALGLGSALPPVMNSKTSMAQRQQSSPTLYNHHNPSQQNQHKQHQQALLNAILGTQQQRPSAGPSPQDILALLELQQAQAAVTQNAHLHAQLALQVQAQQAILAAQTRQNMSSAQQQYLQQLAIAALPTARSPLAQKDPAIRIQDRRSSTKGRHGKADIDTESRTRFESTPVPSPRLPAYATPQMQTLSAFPSAHSPFTRDVSWQSSFSPSAGGGSPAPNAMRTSESPASNLAQNCRPGGAAALSALLSRRTGTEGALPSGEARSPSPPSPSSPVKNNEAIYTNPTAESLSRALLGHGRPGNVQSAERAWTLSAADMANAKSHIDVAPRSASFAGMSVPRTVVVRQPFGPPGAPNELGEKNFQSRIRKQAGRGLGLLSRRGDTPAATPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGP0</accession>
    <name>A0A1Y1UGP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_625364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871271.1">
        <property type="nucleotide sequence ID" value="XM_022015787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGP0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGP0"/>
    <dbReference type="GeneID" id="33557596"/>
    <dbReference type="InParanoid" id="A0A1Y1UGP0"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011005062" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="220" mass="22516" checksum="9610D96C5B7C32B9" modified="2017-08-30" version="1">MFSALSTILTLCLARSALATIYTTSPVASTVATGGQVLNVSWADDGQSPSVSQVGPCSIDIFVGSSTQQVWLQNLGESVDVSKTSAISSTINPSIGQSGDYYFIKYVSLNFKDPKNPQYPYTQYSARFTINAMTGNFNSSVMALIDSTGAPTTSAATNTAAVVVAASTVKSTVQSASASASAAKSSAKVTTAATGAAGQSFTTSATLVLSVLGMATYFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH01</accession>
    <name>A0A1Y1UH01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_627140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870845.1">
        <property type="nucleotide sequence ID" value="XM_022015967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH01"/>
    <dbReference type="FunCoup" id="A0A1Y1UH01">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH01"/>
    <dbReference type="GeneID" id="33557776"/>
    <dbReference type="InParanoid" id="A0A1Y1UH01"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="8">
        <location>
            <begin position="61"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="289"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="376"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="496" mass="53603" checksum="0D2F4499FF8A5E9F" modified="2017-08-30" version="1">MPASRASVVRLLSATTHQGCRGCGRTHGSAHRSLATPADMPIGMPPGKSEYAFEMAASNLRFGVGATNEVGMDLANMINSLPPSERHNAKIGVFTDKNVAHLAVMQKVEASLKREGLDWQLFDKVSVEPTDDSWRNAIDWTRNSNITHFLAVGGGSVMDTAKAANLFANYPEADLMDFINAPIGKGRPIDKKLSPIIAIPTTAGTGSETTGTAILDIKAKKFKTGIASRALKPTLGIVDLDNTATCPKHVAISAGLDVLFHSLESWTAIPYSERSPRPANPLLRPAYQGSNPISDIFSFWALKQTVKYLPRIARDPGDVEARQQMLLAASSAGIGFGNAGVHMPHAFSYPISSLNKARAKERQYMHPSYDPNVALIPHGVAVSLTAPAVFEFTAPASPQRHREAAAVFMGDRAGELDRVRDEDIGRVLGEEVRRFLDLVEVPRGLQGVGYLNEDISSLVQGALPQRRVLDLAPLLSSETAEQVEQLTGIIENSMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH33</accession>
    <name>A0A1Y1UH33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871401.1">
        <property type="nucleotide sequence ID" value="XM_022015847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH33"/>
    <dbReference type="GeneID" id="33557656"/>
    <dbReference type="InParanoid" id="A0A1Y1UH33"/>
    <dbReference type="OrthoDB" id="2594971at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037666">
        <property type="entry name" value="CCDC43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31684:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28404" checksum="DB114C2175C8B457" modified="2017-08-30" version="1">MSAEAESSSQALERYLSEKLSSLSLQVPDDDVEYMARFVEEEGLERDEKIEGVRGMLEGVVEEGSLPESGIDEALGHVVDEWSRLKEEEETKRAEAEEREKLAEPPDLKSILASMTPEEHAAAQRAALLREYGYVDDADALGGSGERDGNAPPKGESARAAHEKAAADERKALIEKALALDGKKKKYKKQQEVDLMAPNLNRDKVAYRAQMEREAAKNAAQQKRDRDKAALDKQRNDAAKAKADKQKKAAKQERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHB4</accession>
    <name>A0A1Y1UHB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_651035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871479.1">
        <property type="nucleotide sequence ID" value="XM_022018254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHB4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHB4"/>
    <dbReference type="GeneID" id="33560063"/>
    <dbReference type="InParanoid" id="A0A1Y1UHB4"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15257" checksum="6B081B26C72F0754" modified="2017-08-30" version="1">MSSPKWIYKIIPHSSVDTRYTFPIPIPASHTFYLSELDYKDGFVHLSTANQVPGTLNRFFADVPSVVLLRLETDRVGSFKRLTWDENDGQKYPHLHAHLEGENVDSFKEVHKGDSEKGWDTALSKPDIAKWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHJ0</accession>
    <name>A0A1Y1UHJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_622237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871508.1">
        <property type="nucleotide sequence ID" value="XM_022015452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHJ0"/>
    <dbReference type="GeneID" id="33557261"/>
    <dbReference type="InParanoid" id="A0A1Y1UHJ0"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="685"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="844"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1119" mass="120146" checksum="1537DF868B70F532" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHR0</accession>
    <name>A0A1Y1UHR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_681400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870694.1">
        <property type="nucleotide sequence ID" value="XM_022019118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHR0"/>
    <dbReference type="GeneID" id="33560927"/>
    <dbReference type="InParanoid" id="A0A1Y1UHR0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="227" mass="25344" checksum="0FECD7B1C7E72F77" modified="2017-08-30" version="1">MSSFTMNTTQGTMQPEVEKLRYGIDLKCLEETNENGTRKWLLSHVNGKWDLDDPNSVAKCWICRVNNSSANDPDGQDPPDLPINSLGYFMTVPTCRSDYLTPASIETLSTELKDMASEVYSAIERVGTEQLPIRSSMRMLEIDTVRNGSITIDVQASVETEGKPDRFGTWYNVLLRNKVLTDTDTDPAEVDDGTGEEMETGVSGEKSEVAGAERRDYQLRSRRTNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI51</accession>
    <name>A0A1Y1UI51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_578977</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871646.1">
        <property type="nucleotide sequence ID" value="XM_022013351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI51"/>
    <dbReference type="FunCoup" id="A0A1Y1UI51">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI51"/>
    <dbReference type="GeneID" id="33555159"/>
    <dbReference type="InParanoid" id="A0A1Y1UI51"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="133" mass="15388" checksum="8EFD3FDAF1D9D2DE" modified="2017-08-30" version="1">MGRTFRVYLAGEYVYCCRVCGNHLAVSESVISTQFRGQHGKAMLIRHTVNVYTGEPGDREMSTGKHTVRDLFCKVCHTTLGWKYDFAHDPDQKYKEGRYILEREMITEVPEGKRETGRPKIEEISVRELMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIB1</accession>
    <name>A0A1Y1UIB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA primase</fullName>
            <ecNumber evidence="11">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_623331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871778.1">
        <property type="nucleotide sequence ID" value="XM_022015568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIB1"/>
    <dbReference type="FunCoup" id="A0A1Y1UIB1">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIB1"/>
    <dbReference type="GeneID" id="33557377"/>
    <dbReference type="InParanoid" id="A0A1Y1UIB1"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="425" mass="49010" checksum="9C6121FD9A4A992F" modified="2017-08-30" version="1">MAIAVNEHADYDPSSPQVMNAFYRRLFPYRPFFLWLNQDHVPAKLYTHREFAFTLQGDVYIRYNSFHTADEFKREVLRLNPSRFEIGPQYSARPRDRKTLPAGALQPQRRELVFDIDMTDYDEIRTCCTDKKICKRCWGFIAAAVKVLDHGLRETFGFKHLLWVYSGRRGIHCWISDPAALDLTDDQRKGLVTFMEVIKGGKEQAKKVNVRGSKDEGSLHPVLKESLELLKPEFVDVCLRDQDCFRSEQGWETLLALLPTDRDVVGPLRADWKNSDKSSMAKWEQVMKLVGEMRTSNSPLFRKYERALEDIILQYSYPRIDAEVSKHRNHLLKAPFCVHPGTGRICVPVNPSLVDEFDPALVPTVGELLNELDRIPPDSGEARKADDYEHTSLKPYVDMFEKHVAAILRDSRGAKRAAKEESMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIB3</accession>
    <name>A0A1Y1UIB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871315.1">
        <property type="nucleotide sequence ID" value="XM_022015807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIB3"/>
    <dbReference type="GeneID" id="33557616"/>
    <dbReference type="InParanoid" id="A0A1Y1UIB3"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18607" checksum="D3BB2257F7C4ECAF" modified="2017-08-30" version="1">MSSNILTDPIPELEQALKTNLFGIQPSSHVMLDRSFPHTAEDKAAIVEESKKTGRTSDRAVARARIMLLDGGGIGEMEVVLDQRGYTVERISDAASNLHTYLQQTYESLETLLIAVSPAYVQAMTMEVSKRFEGFSGRPENSTEEDPYEIDRRAENAALGGEQKEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIN0</accession>
    <name>A0A1Y1UIN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_650434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871878.1">
        <property type="nucleotide sequence ID" value="XM_022018144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIN0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIN0"/>
    <dbReference type="GeneID" id="33559953"/>
    <dbReference type="InParanoid" id="A0A1Y1UIN0"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="302"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="698"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="333"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="880" mass="97430" checksum="B6635040F31E4EFD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ53</accession>
    <name>A0A1Y1UJ53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_413408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871986.1">
        <property type="nucleotide sequence ID" value="XM_022012718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ53"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ53"/>
    <dbReference type="GeneID" id="33554526"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ53"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="33433" checksum="2608DE8B6ADC4C19" modified="2017-08-30" version="1">MPPRRPRPSAPPIMTPAASIKSESGASTPGTETSSRVKITTRSRKVKNTGLVTPISVGDEQEMKSVKVEVQELEVEVSPTSAPSTPAQTSAETSPTPSSRTSTRIRYKLDSVQIPSSNKRSRLGVEKTTSADNLTLTSTTRASRSRASDPHSDPIDSLSAANPSDDAKPSLQPDLFSIRDEVASSSASTTNGPRPAHQPFNIGKFSRVQKASAASLALDVPPKRRASARGKGKAAIKKGPESFSDTESEAEGEQVGDDFAMDSEEETAQLKRALKASKSSGKAESSSKAAPRGTAKATRGPALNGPALRRAAAKAAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ55</accession>
    <name>A0A1Y1UJ55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_622252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871511.1">
        <property type="nucleotide sequence ID" value="XM_022015454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ55"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ55">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ55"/>
    <dbReference type="GeneID" id="33557263"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ55"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="119" mass="13641" checksum="AF9B2CCDA85BFADC" modified="2017-08-30" version="1">MQRPNDPLASRALFIKNLNFNISGNDLYDLFGKYGAIRQVRLGTDTNLKTKGTAYVVYENPDDAREALTHLNGFHLMERYIVVLYHQPSKQQASALAKAEIRAREQALEMEKRRLGMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ69</accession>
    <name>A0A1Y1UJ69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein UFD1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_622278</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871521.1">
        <property type="nucleotide sequence ID" value="XM_022015455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ69"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ69">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ69"/>
    <dbReference type="GeneID" id="33557264"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ69"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="127"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="460" mass="49083" checksum="25A67B442F86958D" modified="2017-08-30" version="1">MGGSRGFGFGGMGFGGYGMVPPPSAFDEYYKAYSVAVMGGNERSELLYGGKIVMPPSALAKLSAMEIPSPWTFHLRNPRNPKVNQTHAGVLEFIADEGIVHLPAWMMKALEISEGDPIRLTGAELPKGKMVKIQAQSTAFLEVSDPKAVLESALRFYSCLTKGDIIEITYNSLVFEFLIMETTPEGAGISVIDTDLEVDFATPVGYVEPPRPAPAPIPTMADKLKIDLGGTTTGSAGSSRSVSRASGGSGESGPLESFTGVGQSLSGKKVKGKGLAKKIEEVDPKSRINRNGGNRIVTPDSLTDDRKVPAALVLPEGKFFFGYKYIPFDSSKQPKKVEAPKSPDPFQGQGETLRKTGGISRPQPVLSGQNGTAPESVAVPSPEEKIDPWAKLGSGNTLRPKRPAPSMPTPEPAHNRVRSNQPAAPPPPSNVIDATMLDEDDFGFVDSDDDEHEVIEIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJC5</accession>
    <name>A0A1Y1UJC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871263.1">
        <property type="nucleotide sequence ID" value="XM_022015785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJC5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJC5"/>
    <dbReference type="GeneID" id="33557594"/>
    <dbReference type="InParanoid" id="A0A1Y1UJC5"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="221"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="46019" checksum="4C74E199B1FDA64D" modified="2017-08-30" version="1">MPHILAINCGSSSIKGKLYAIPSSSSEPLSAVATLGVSNIGAKGEKVQIKVKWSNEGDRDVDEEGDDGDSVDYKAMVPLLLDKIISSGSVQKDDIKYVAHRVVHGGEHKRGIRISKGHEEGLAEMDALSEFAPLHNHHAVLAVRSCLDALPNHTSLLLFDTLFHQTIPPETYTYAIPPPDTKIVMPLRKYGFHGLSYASIVSQLAEHLGKPESKVNVVVAHLGSGASSCCIKRGQSIDTSMGLTPLEGLIGGTRSGTIDPTAIFHAISDPGSDAGLEGMKVSKAEMILNKKSGLSALAGTTDFGLILSRLDASKVSADDHRSASLAYAVYLDRLLGYVSQYLFKLLATTPLSDIDGIVFSGGIGERGAKLRHDVLDKFTWLGAEIDSRANDVSQGSVREITVQGSKLRGWVVETDEEGLCAELTRQDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJX0</accession>
    <name>A0A1Y1UJX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_351167</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872282.1">
        <property type="nucleotide sequence ID" value="XM_022012555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJX0"/>
    <dbReference type="FunCoup" id="A0A1Y1UJX0">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJX0"/>
    <dbReference type="GeneID" id="33554363"/>
    <dbReference type="InParanoid" id="A0A1Y1UJX0"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="109" mass="12599" checksum="DE78595F7034ED09" modified="2017-08-30" version="1">MLFCPYCANNLTIGDSNAEENRKAWICPTCPYQSIITQQISMRTHMKIKKVDDVLGGKESWANVDKVEAACPKCDSRQAYFRQLQIRSADEPMTTFYKCVECAHQWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJY5</accession>
    <name>A0A1Y1UJY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872221.1">
        <property type="nucleotide sequence ID" value="XM_022015269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJY5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJY5"/>
    <dbReference type="GeneID" id="33557077"/>
    <dbReference type="InParanoid" id="A0A1Y1UJY5"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="340" mass="34799" checksum="675B0DD33D58296A" modified="2017-08-30" version="1">MSSNSSIVPTVDSYLSTICSSDPCTNTTLTSVADSIIQGCASDLTKFGVDNQTVRDMIDLYPLAREVVCLKTEDPESLNNATIPLDSTAYNTTNGTFCVTELLTDLSGYIGANLTTKYIETVVLGGNGSALQILEHVPIEAICTDCIFAAIDVVYTEYPAIGNYSVGKNMTIDGWLNMTCPAYNTTTNGTLPASIDEVAANSTFPETIIGAHGTYTPGSAAVPAPTLNSTNEQQWGIASLVGASVYSTAAAAATDAVPTVTGMPMMSGAPSAPAMPSAAASGMPSGGVMSVISSALASGGPAGPAGPAPTLQAPSGSVSAPAARRTLGNMQEKKRWIGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK89</accession>
    <name>A0A1Y1UK89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_599308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872390.1">
        <property type="nucleotide sequence ID" value="XM_022013903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK89"/>
    <dbReference type="FunCoup" id="A0A1Y1UK89">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK89"/>
    <dbReference type="GeneID" id="33555711"/>
    <dbReference type="InParanoid" id="A0A1Y1UK89"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="21606" checksum="FC6A700CFCA14C47" modified="2017-08-30" version="1">MFASNSRAASSTATRRYGHEINMVQICLMCRSLMKEYRDLTADPLQDSITAGPISEDNMLEWEALIQGPEGTPYEGGIFAARLVFPPDYPLNPFKMTFDPPILHPNVYRNGEVCISILHPPGDDPLRYESASERWSPVQGVRSVLLSVLSMLAEPNVESGADVECCKLFRDNRLEFDRRVREQVRNLLGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKC1</accession>
    <name>A0A1Y1UKC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_680787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871903.1">
        <property type="nucleotide sequence ID" value="XM_022019095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKC1"/>
    <dbReference type="GeneID" id="33560904"/>
    <dbReference type="InParanoid" id="A0A1Y1UKC1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012078758" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="29233" checksum="16175907B4899855" modified="2017-08-30" version="1">MRPYKAFASLAALSTVVGSGPIVVGRAASSDKGQLYQLLSGAGNAYAELRNAEDNGEQLTGIYHHPNQYRDKYNTEGDMATDADFLFIADDRSFNRVGISFIPNLDITDDKGGTHSDFPKLADPEFLKKCKRESFSGTATFSTEEQCPDSLDPGSLCMRVVTAPVTVTGDMRVGQTRSVHGMDMDPQYYVTLDSEALGGSHEVLAIRRMSAGYRWSDAAFDAKLDKNGNLSLSNKRAMMTKTGPPRSLIPCTGLSPVSGRFWPLLPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKG7</accession>
    <name>A0A1Y1UKG7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fcf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_621323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872472.1">
        <property type="nucleotide sequence ID" value="XM_022015372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKG7"/>
    <dbReference type="FunCoup" id="A0A1Y1UKG7">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKG7"/>
    <dbReference type="GeneID" id="33557181"/>
    <dbReference type="InParanoid" id="A0A1Y1UKG7"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="181" mass="20886" checksum="B8701E288389ADBC" modified="2017-08-30" version="1">MIKPSDPRLKENVEKAAKKAEKEKQLEEKKRIPQVSAAMFLAHNKDLGPPFRVLVDTNFINFSIQNKIELVQGMMDCLMAKCIPVITDCVLAELEKLGPKYRLALRIAKDPRFERLHCDHSGTYADDCLVQRVSLHRCYVVATCDRDLRRRIRKVPGIPLMYVVKHRYQIERLPDAGSSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKJ9</accession>
    <name>A0A1Y1UKJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_367609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872500.1">
        <property type="nucleotide sequence ID" value="XM_022012595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKJ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKJ9"/>
    <dbReference type="GeneID" id="33554403"/>
    <dbReference type="InParanoid" id="A0A1Y1UKJ9"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="92" mass="10453" checksum="8EB72B8865AEF8E7" modified="2017-08-30" version="1">MGSIADLHAKTYEIVRMIPPGHVTSYGHIAKLAGYPRYSRHVGNALRDLPAGSTVPCVSYPRLVRFLPVAMRVKLSRGRKLHWRKMGWKWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL49</accession>
    <name>A0A1Y1UL49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_343415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872146.1">
        <property type="nucleotide sequence ID" value="XM_022012526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL49"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL49"/>
    <dbReference type="GeneID" id="33554334"/>
    <dbReference type="InParanoid" id="A0A1Y1UL49"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35800" checksum="200221CC7578C86D" modified="2017-08-30" version="1">MITVEPNAYYVALIQRNQIFTGDCRDVEEVDDGDHVDDGHDSMNKFFTGLADALAWGGGKRFKGRDLSGNKYYEIAKPSGGGRPKRSVKYNNIEHLSDYTSGKVNLPVQWRAWLSHTRPNPPSVEELEADHLRQTNLTPLVAAIEERERAERIRQGYASDSDIRLSIHSHSPEYHRLFGGDAIAGPSSVKVDESRSRRSAVESIDQSQREHYASIDGDTLSSGPSTSHRLSTPAAPLEENAPRSPYPIPTPTSPGVPPPPDVVDPSQHATKEDLRRLSEEDTKRRMAETGTPQPWVPSPKPPSAPEQGVLKPRRRGGSASFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULV4</accession>
    <name>A0A1Y1ULV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872886.1">
        <property type="nucleotide sequence ID" value="XM_022015007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULV4"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULV4"/>
    <dbReference type="GeneID" id="33556815"/>
    <dbReference type="InParanoid" id="A0A1Y1ULV4"/>
    <dbReference type="OrthoDB" id="5564877at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473:SF1">
        <property type="entry name" value="DINB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30572" checksum="EA4A6C152887AFF7" modified="2017-08-30" version="1">MTLSSDRKSSRKPPPDLDHSRAGSSSSYQSSKSKMTSDDDRALALLDMAINLVDSALDILFNHLKTDDQLRKSSLLMPGGTVGKHFRHVIETYRAFLAPLHPRSTTLPLGKLVINYDAFLPSTRRPLARSLPACRDAMSSVRDDLVAWGNRCREGSTRSTGSSSNSSRRSTRSGSEKSREGVDSTPSTSGLAKEMSIPVELIAITPTKEVLSSSIGRELWFCSLHAIHHFSMLRTIAVHELGLDLPVEFGTAPSTLLYRGKGWQLPDERKIKVVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULW0</accession>
    <name>A0A1Y1ULW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_576638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872903.1">
        <property type="nucleotide sequence ID" value="XM_022013202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULW0"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULW0"/>
    <dbReference type="GeneID" id="33555010"/>
    <dbReference type="InParanoid" id="A0A1Y1ULW0"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="239"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="617" mass="68207" checksum="ED70683A0FAF36B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM47</accession>
    <name>A0A1Y1UM47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872991.1">
        <property type="nucleotide sequence ID" value="XM_022017953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM47"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM47"/>
    <dbReference type="GeneID" id="33559762"/>
    <dbReference type="InParanoid" id="A0A1Y1UM47"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="297" mass="31562" checksum="3ED292B901E8F2BE" modified="2017-08-30" version="1">MSLRTSLRPALRAQLSRAFIHTSPALDPAPGPPLPDIAATSVTASPPSTIGESSVDAQASSCSSSASSSSTVSSATAAARKPRLTQFRADPKYAKLLSTPPKPIASLPSHLPPLISESSSPSPSSSSSSSSSSSSSSSSHTSSTALPKSIPSAISLLKSQSTPSTGIYVLARLHTRTYLLHPRDILTLPTLKPVKRPGTTLSLTRILEVGSRDYAIRSPSADAKVLRKYMDYDARSLETVPMSIAKVQVTVLEHTRGVMMTRFKYKRRGGFRKTIRRKPGWTRLRVGDIILGDGGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM99</accession>
    <name>A0A1Y1UM99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_618723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873034.1">
        <property type="nucleotide sequence ID" value="XM_022015073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM99"/>
    <dbReference type="FunCoup" id="A0A1Y1UM99">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM99"/>
    <dbReference type="GeneID" id="33556881"/>
    <dbReference type="InParanoid" id="A0A1Y1UM99"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="235" mass="26770" checksum="161AB6A8F3629202" modified="2017-08-30" version="1">MVKKRMPRVYLIRHGETEWSLNGRHTGSTDIPLTENGERIVKEMGPRIFGPNNLINPEHIRHVIISPRQRAQKTAELLFGSHPPPSCSFTTDPDVQEWDYGKYEGMLTKDIRKEKPDWSIWDDGCPPGSETPGETPQQMSDRVDKVIEKVRKIHREAEQNASGPDDVDHSDVIIVSHGHFSRSFIARWCDFPIQAGYHFAADAGGLAVLGYQHMTLKEPSLMGLNWYTEDSLQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UME6</accession>
    <name>A0A1Y1UME6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_620375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872227.1">
        <property type="nucleotide sequence ID" value="XM_022015274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UME6"/>
    <dbReference type="FunCoup" id="A0A1Y1UME6">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UME6"/>
    <dbReference type="GeneID" id="33557082"/>
    <dbReference type="InParanoid" id="A0A1Y1UME6"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="163" mass="18009" checksum="59F7A35D42D06462" modified="2017-08-30" version="1">MSSGSKQYKAIGDDVWKRTDKVNAELFTLTYGALVVQLIKDYEDYGEVNKQLEKMGYNMGTRLIEDFLARTGLQRCSSFAETAEVISKVAFKTFLNITPTLSFPPASAQPSNPSLPQPSEFILTLDDNPLAEFADLPRDAKEGGLWFSNVLCGVIRGALEMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMS9</accession>
    <name>A0A1Y1UMS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BD324DRAFT_619382</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873221.1">
        <property type="nucleotide sequence ID" value="XM_022015166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMS9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMS9"/>
    <dbReference type="GeneID" id="33556974"/>
    <dbReference type="InParanoid" id="A0A1Y1UMS9"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 24" id="KW-0732">Signal</keyword>
    <keyword evidence="23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013141395" description="chitin deacetylase" evidence="24">
        <location>
            <begin position="19"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="25">
        <location>
            <begin position="178"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ORX39358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="480" mass="49705" checksum="EF210E41F8E81955" modified="2017-08-30" version="1">MYTSPLVVLLSLVSAVHAQSSDASSAGATPTSSQNGAGSAPTSSFSVDPNLPQTPLTMVAGQTIPNLAELTSGAPVQSGVPLATTYSQGIQPSVSRAPALPNPTLTVSNYPALDLTPPTDSPEVQEWLSKIDMSKVPNYSQTDGTCAGSPGAISDGRCWWTCGGCTRSSDITICPDKMTWGVSYDDGPSPYTPLLLDYLAAVNISTTFFVVGSRVISRPEMLQAEYIQGHQISVHTWSHSSMTTLTNEQIVAELGWTMKAIRDVIGVTPNTWRPPYGDIDDRVRAIAAQMGLTAVMWSAITENGVTTDFDTDDWRIPGGAANGPSSLSKFNTILDTYVPSLSTGFIVLQHDIYQQTVDLAVGYVMPMAIQSGKFTFKSIINCLGYPNSEAYIETSSNTTQTAITSAASTFYQASIGSATGAAVTASGVSASGSAGPSSASGSSSASTSGAATRSANLGLPGLAPVVVSLLALGLGAVIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMY9</accession>
    <name>A0A1Y1UMY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_291404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872679.1">
        <property type="nucleotide sequence ID" value="XM_022012394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMY9"/>
    <dbReference type="GeneID" id="33554202"/>
    <dbReference type="InParanoid" id="A0A1Y1UMY9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="239" mass="25758" checksum="1E8F4F9A6EB08A46" modified="2017-08-30" version="1">MPSISEKRGLPGLVIDTIAASPSMSSPTSPLTGSSHPTPTTPYSPYPMTPSTPPMYGPLVGHSDKTGRRIPNRPLSSRTLPPRFCEVVSEEPREIIMGGLVTRSSTASSRRGSAESQWDEKRIASIEVPGIILTEPHPEPHPRRSSTPPPKSILLLPPTSLPLPDDTDYRTCDPFRIFYRASPGPTASTPKRPSSHLVSILKSIALLGVVGVGAWHLYTSLSITGWTDEMTGLAEELAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNP9</accession>
    <name>A0A1Y1UNP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_614365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873407.1">
        <property type="nucleotide sequence ID" value="XM_022014590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UNP9">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNP9"/>
    <dbReference type="GeneID" id="33556398"/>
    <dbReference type="InParanoid" id="A0A1Y1UNP9"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="187" mass="20228" checksum="0D4C1FF9F7D392FB" modified="2017-08-30" version="1">MALPRSSYDPRRVFTIAFPKFEVGPKTRQIGTYLAGILFTFSFFLLFDAATLSSHAKPPADSPHDVVPVHMSFVDWIPAICSTVGFLITSLLDKSHLQSAFSGDSWGSEGPAAVRARVVLFIGVAFMAGGLAGSLTVLILKYIIPDYIGYIYYGGANVGMNAGIMLSAMVLWVAQSGSDEYEYQLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNR1</accession>
    <name>A0A1Y1UNR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_618742</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873040.1">
        <property type="nucleotide sequence ID" value="XM_022015077.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNR1"/>
    <dbReference type="GeneID" id="33556885"/>
    <dbReference type="InParanoid" id="A0A1Y1UNR1"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="480"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1568"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1958"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2041" mass="229805" checksum="970EECE01152778D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP38</accession>
    <name>A0A1Y1UP38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Brt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873099.1">
        <property type="nucleotide sequence ID" value="XM_022015100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP38"/>
    <dbReference type="FunCoup" id="A0A1Y1UP38">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP38"/>
    <dbReference type="GeneID" id="33556908"/>
    <dbReference type="InParanoid" id="A0A1Y1UP38"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="128" mass="14036" checksum="0B14A8C6E414797C" modified="2017-08-30" version="1">MPAEYILTKEAPPPLPVYSQAVRAGNYVYTSGSVGMTKDKQMVEGTVQDRTRQVINNLEEVLKAAGMTLKNVVKANIYLSKLSEDFESMNEVYEKMMPDPKPARTCVGVAQLPAGGTDVEIEFVAYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPC6</accession>
    <name>A0A1Y1UPC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enhancer of mRNA-decapping protein 4 WD40 repeat region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_619680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873290.1">
        <property type="nucleotide sequence ID" value="XM_022015194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPC6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPC6"/>
    <dbReference type="GeneID" id="33557002"/>
    <dbReference type="InParanoid" id="A0A1Y1UPC6"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1192" mass="126005" checksum="3271982EE8077657" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPI9</accession>
    <name>A0A1Y1UPI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_244629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873718.1">
        <property type="nucleotide sequence ID" value="XM_022012264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPI9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPI9"/>
    <dbReference type="GeneID" id="33554072"/>
    <dbReference type="InParanoid" id="A0A1Y1UPI9"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023278">
        <property type="entry name" value="Ethylene_insens-like_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116768">
        <property type="entry name" value="DNA-binding domain of EIN3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="495" mass="55442" checksum="07A1F29961DF8E5D" modified="2017-08-30" version="1">MPRIPVRTTPYHTLPRCTRHYKSKRDLILRALGKASFINGSQFVIAWISPKGEVDVYASELLQTSVSNKEGGILCRKELDREATRVKGEMGRRWEDIRRLEESGEAPSMEDDEAQDETFEEDDMDVDPDRTMVDDDDSMKKTLQGLGLTAPRPNTPASSMHTLTLAPDATENYYTSRFAALQQATCKLVVKAWIKVIEPKKQMKFPYNKGEELKPLWWPEGVRHREPDHLSKTERLTLLTSIVRSPLVTVSRLELSTAEAAAFISRPRLAVLREVYLVAKEEERKRKEGDLSPDLVVQLPNIPISPSDVSPEASSEKRSHAQFEASISMADKENVPSVVHQKRLKTQPLPRLAPLVASQSNTSFFEQPAFYAQNVQPYLSPYPSEFGYAGSDYGRSPNPEMGMIDRSTYPSHPGHLAPLLNHSHTHSPVDSPAFPQSATLAPPNSASAFYTRGSNGPSYMQQQQVEYLQSHAPGYDYGSPYLADNAWEGSFAQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPZ0</accession>
    <name>A0A1Y1UPZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_678693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873359.1">
        <property type="nucleotide sequence ID" value="XM_022019008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPZ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPZ0"/>
    <dbReference type="GeneID" id="33560817"/>
    <dbReference type="InParanoid" id="A0A1Y1UPZ0"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="367" mass="40443" checksum="522D01AA665892A9" modified="2017-08-30" version="1">MSVKVACHCGAFKHDLEITTDIPHEDTFCCCDSCRRRTGQLGLFPFPASASDSELVTKSSLKRYDTQPGTGNTVSSFYCGQCGSKVFIQTVGPDQEFKGGGWMLGCFDKMELNDKCLIDIHGFSFADETIDGGAAAFWTQVNGKPLKSYVGCEAEWKAPAEAGRDDSEYLNLHCRCGGFDVHVSRPNPELPLPKPCWWYLPPKTEAGIPQRYMASWCACKDCRGATGSCLPAHPWVQIPFVDIHTATSKDAPLLPAETKMTTKTDLPGCTRYESSKGIARYFCSTCGATVLYFDADRDFIGAWAVGLIDSKEGSLAPSWLFWWTGRDGHPNPPIHCKETGDAFWGKGIMSDFESGWIEWGKKVGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ24</accession>
    <name>A0A1Y1UQ24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_616626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873945.1">
        <property type="nucleotide sequence ID" value="XM_022014841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ24"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ24">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ24"/>
    <dbReference type="GeneID" id="33556649"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ24"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="50533" checksum="172350765028462B" modified="2017-08-30" version="1">MSLFSSAFDDGPSFGAGPSRSPKSVQQASSKGVTGRQQETKTKARPSTGQSHQNESSSHRDRNQQQASRGSRPSEVRDQKKKKLKGNAKPQSGQAGAMDRIEETKRNLEKLMTRLDGGIREDKEDARPMGSGNGNKKRKKAVEKERQDHDASSSLPKTKHPSAGSGSTPKRAKVNPGKVTPGQTTSGSVSGQTTKKSEPGVQGLTKMQKGMQTKLEEARFRWINEQLYSNSSSDAVEMMKKDPKVFSDYHSTHRILTAAWPTPPLPYILEKLTPLPAKTVIIDLGCGDASLAQELVPRGKTVLSFDLVGDSRLVGVNGERSSSTGGWVVEADFLNHIPLPGRSGRQGSPSESRSEVVDVAVCCLSLMGTNWVGGIYEVCRVLKQGGTFHIAEVTSRLVSNQDFVDKISSFGFELVEMSSPSTHFTLFEFTKTTAVPYGPVKGEVGWSERVSEGESIMKGCVYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ59</accession>
    <name>A0A1Y1UQ59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_616657</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873956.1">
        <property type="nucleotide sequence ID" value="XM_022014843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ59"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ59">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ59"/>
    <dbReference type="GeneID" id="33556651"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ59"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000038">
        <property type="entry name" value="exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="12">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="11">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="255" mass="26953" checksum="3C6160665528B128" modified="2017-08-30" version="1">MTFVLPGDVIPTATSQTSFGPGLAPLDTSNQAGPSRARGQFTSSTSSEGNSTESARVVATKAGTLVSSDGKGKKGGVWIESNSRRYTPASRDLVLGTIIARHADGYRVDIGSASMASLDALAFEGATKRSKPNLKVGTLIYARVSLASRDMEPELECFDPATGKSDGFGELKEGLVVDCSLQLCRRLLTPKNPLLPILASVIPFEIAIGLNGRIWFKSSSIDETIALQRVIQGIDDGSLAETKGELEKALKAYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQE0</accession>
    <name>A0A1Y1UQE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_607302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874065.1">
        <property type="nucleotide sequence ID" value="XM_022014060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQE0"/>
    <dbReference type="GeneID" id="33555868"/>
    <dbReference type="InParanoid" id="A0A1Y1UQE0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="179" mass="20087" checksum="7EF7055291B5D8F6" modified="2017-08-30" version="1">MSSAGGDKSSDGCTTTFVNLPDVPERDTWRTSHPTSVGGKEPEEPEEPEEPEEPEEPRITDLKASQTFKLKPTYTIKDDEWVDKGTDYYHNRPQREYTSDDENEDEGGTFYEARETQAGADTHLTGVSTVASQGAGSKTAGRLSRRLTLPNAPPSDRQEPWWYILPTFRSPAYYPMHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQH3</accession>
    <name>A0A1Y1UQH3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874076.1">
        <property type="nucleotide sequence ID" value="XM_022017900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQH3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQH3"/>
    <dbReference type="GeneID" id="33559709"/>
    <dbReference type="InParanoid" id="A0A1Y1UQH3"/>
    <dbReference type="OrthoDB" id="2333993at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="965" mass="105645" checksum="B05F398206D5B1B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQW2</accession>
    <name>A0A1Y1UQW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873752.1">
        <property type="nucleotide sequence ID" value="XM_022014752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQW2"/>
    <dbReference type="GeneID" id="33556560"/>
    <dbReference type="InParanoid" id="A0A1Y1UQW2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011004152" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="13480" checksum="B92065E92EF9A9CD" modified="2017-08-30" version="1">MLSNLYTLLFTLLVSSAAMADRTVRINAVDGACIRTGSSCGGGMTLQLKDDGTPYPTLDYHVGVPGVAEKEEVGCHWEGKLDDGVDQVTFTFSSGPDYLYPCGPQKGITMVCDNPPATCASTPRENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQZ7</accession>
    <name>A0A1Y1UQZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_3116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874159.1">
        <property type="nucleotide sequence ID" value="XM_022012457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQZ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQZ7"/>
    <dbReference type="GeneID" id="33554265"/>
    <dbReference type="InParanoid" id="A0A1Y1UQZ7"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="44"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="220" mass="23062" checksum="F4CB577CC0D5153D" modified="2017-08-30" version="1">MATPAQSRSQSGSAQASGSAAASGSGSARSNSTTATTSISIPATAAAGGVTVTQPPSTGEASYYKIASGEYITFGWNFTSLYVQPEHLTIIASCSANGNTYPVGPTASPSNTLAANATNVVWSPWEWEQIQGQVPFAEATYVLKMWDQRGPDVGIKGGYLSPYAGTEFALYRPGPYVSIADGWTCSTCNAGFERLSDPLGLAAMLTFASVIFSVWNVWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URR2</accession>
    <name>A0A1Y1URR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_617260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874092.1">
        <property type="nucleotide sequence ID" value="XM_022014904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URR2"/>
    <dbReference type="GeneID" id="33556712"/>
    <dbReference type="InParanoid" id="A0A1Y1URR2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="81" mass="9207" checksum="E8B91822F4C86645" modified="2017-08-30" version="1">MTAFASLKRSIRRILNHLFERSSMFLLAIISTALVAGVALAETGQLRHRAVQDKAMSRGRYREAEWVEPLTELNALKFHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URR4</accession>
    <name>A0A1Y1URR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_18801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874432.1">
        <property type="nucleotide sequence ID" value="XM_022012129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URR4"/>
    <dbReference type="GeneID" id="33553937"/>
    <dbReference type="InParanoid" id="A0A1Y1URR4"/>
    <dbReference type="OrthoDB" id="2593594at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="368" mass="36882" checksum="BF2C35FC0DD4307C" modified="2017-08-30" version="1">MNTVGAILSSMPADPRMAPGSLSQATATPHGPAGATAQTSGFVEAKSGDGTHVTGVSSTKPSTSTTTSSSTNQSTSPGSSLLAEAEARFSSISAGIGSFLSSGGSADGHPPVLPAGHSTTGFLTGFNPSLQPGGGLATNPLVPRPGESIDPATGKPHQAGLTRAQLEAKRAAEASGASIAASSMSGTASGSGTHLEDLSGREQAARQLTGTVPVPALAPAPALPGTRIGAPIDPAGANGTGHHSVLDDVNHGLEKVVDMLPQGLKERLAGVNDPKGKMSEAEREKRLSAQGILESARQQGGRIFQDFKESFNEDFRSSPKSDKSGAGSTGVIASVKELWTDVTGPGAGNLSKGPSGGSIRRLQRSLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URU9</accession>
    <name>A0A1Y1URU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_644486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873670.1">
        <property type="nucleotide sequence ID" value="XM_022017593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URU9"/>
    <dbReference type="FunCoup" id="A0A1Y1URU9">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URU9"/>
    <dbReference type="GeneID" id="33559402"/>
    <dbReference type="InParanoid" id="A0A1Y1URU9"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="44"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="393" mass="42570" checksum="E51A2184825B1045" modified="2017-08-30" version="1">MPILGLTVPGPAHPPHFSLERLIRPNILSLEPYRCARDDYSEGVLLDANENAMGSVLPKKLDPVAAQTLEHVQGDLNRYPSPTHDDLKRKIAKFRGVPDEHWVFLGVGSDEVIDLLFRVLCVPGKDKVMTTPPTYGMYGVTAQVNDVGVVPVPLTADFQLDEAKMSASLAEVKILFVCSPGNPTGTVIPLDAIKRVLDNPTFTGVLVVDEAYIDFAPSGSSAASLVNEYANVCVTQTLSKSFGLAAIRLGYLLAPPPLVQILTNAKAPYNISLPTASLALSAVSDEGLAEMQRVAATLNDNRDTLIRDLRTIPRIGRVLGGNHANFILVEVLNKAGEPDVQLAMEVYKTLADSRGVVVRFRGKEPGCKGCLRITVGTEKECKLVTERLRELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US23</accession>
    <name>A0A1Y1US23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear pore complex assembly-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_615805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873770.1">
        <property type="nucleotide sequence ID" value="XM_022014760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US23"/>
    <dbReference type="STRING" id="4999.A0A1Y1US23"/>
    <dbReference type="GeneID" id="33556568"/>
    <dbReference type="InParanoid" id="A0A1Y1US23"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="43"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="859" mass="94265" checksum="13DA617BEFE73A29" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USG5</accession>
    <name>A0A1Y1USG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetrahydrofolate dehydrogenase/cyclohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_647842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874618.1">
        <property type="nucleotide sequence ID" value="XM_022017727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USG5"/>
    <dbReference type="STRING" id="4999.A0A1Y1USG5"/>
    <dbReference type="GeneID" id="33559536"/>
    <dbReference type="InParanoid" id="A0A1Y1USG5"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="2">
        <location>
            <begin position="231"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="3">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59264" checksum="AF6CA414605EA597" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USH6</accession>
    <name>A0A1Y1USH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="2 12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_612653</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="2 12"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874628.1">
        <property type="nucleotide sequence ID" value="XM_022014418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USH6"/>
    <dbReference type="FunCoup" id="A0A1Y1USH6">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USH6"/>
    <dbReference type="GeneID" id="33556226"/>
    <dbReference type="InParanoid" id="A0A1Y1USH6"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000004">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="139"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX40949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="281" mass="32396" checksum="074DDD4B1DE99072" modified="2017-08-30" version="1">MAKSRFEYVKSYELPDILLPGTYIIARVDGRGFHKFSDAHSFEKPNDRRALNLMNHAAGCVMEDLKDVICAFGESDEYSFLIRKSSKLYNRRRSKINSTIVSIFTASYVFYWPKFFPNTPLQSPPSFDGRVVLYPSAREIRDYFAWRQADTHINNLYNTAFWALIQHGGLSTTEANKALQGTDSKDKNEILYSRFNINYNNLDSIFRKGTILVRRPIEPPQELTIPNESSGVNAKPVDETRPQVKPKRQEQYEGVTGELDILHEDIIKDGFWNARPWLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI8</accession>
    <name>A0A1Y1USI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_616642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873950.1">
        <property type="nucleotide sequence ID" value="XM_022014842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI8"/>
    <dbReference type="GeneID" id="33556650"/>
    <dbReference type="InParanoid" id="A0A1Y1USI8"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="765" mass="85201" checksum="482344DA3470B1D6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USW0</accession>
    <name>A0A1Y1USW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874293.1">
        <property type="nucleotide sequence ID" value="XM_022017678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USW0"/>
    <dbReference type="GeneID" id="33559487"/>
    <dbReference type="InParanoid" id="A0A1Y1USW0"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="41695" checksum="D8DB91BB8899DEF0" modified="2017-08-30" version="1">MEDGIVKIDDISPQIIYGPEGTWKAPTLANDGGGALMSYMDSTFHMTTGEGSYATLLFNGSAVTAFGALRGNHGVYQVFLDGKLVNETLGAGNDLYQQVLWKGEGLGLSHHNLTLVNRPSLTNLSLLPDPGGWIYLDIDFFLVNPAGPLMTGSIVTTQHDDGDSAFKYSGSGWSTQQSDMNQGGGFRQSSTPGDSVSLSFFGPRVQIFGNLGWQYATYSVSIDGGEQTTYIGNASQLYSKVPLFTAAMLGNTSHTITLTNVAADSPGNLAIDYAVVNYTLDSASEASASSAYSLPVIPSVVIDPSVVTSDFQPEPSSRTSHISLGSSLRSTSTSAPHLVSTSQIPGPSIEAGNSQSSASLATQHPAVIWSPIVAAIIVSGLLLALWIWTKRRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTW9</accession>
    <name>A0A1Y1UTW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_611591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874314.1">
        <property type="nucleotide sequence ID" value="XM_022014284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTW9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTW9"/>
    <dbReference type="GeneID" id="33556092"/>
    <dbReference type="InParanoid" id="A0A1Y1UTW9"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33392" checksum="DEB0DCB036ACA874" modified="2017-08-30" version="1">MIQYPWHSMRICGIRSLRFTARTTYSQKRTSQRLSTMPIALITGASREDTIGFEVARQLGAKGYDLILPTRSIDAGRKVSEVLKTKHEVNNVHVVELDLTKPESVKACADEVKKQTGALDVLVNCAGISLASTYDKGIEALKGWKDYSLTEGLRAIDTTHDDLEAIFRTNVFGAIELTNALAPLLLQSKAPRLVFVSTTIGTFESADKPDAFNHYFFAYASSKAALNMAALSYSKQLPKLNPAIKVNLVCPGYPATALNGYQGFGTTPDSAIGIVELATVDEHGPNGEFLAAYAPYGEPGKMGRVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU28</accession>
    <name>A0A1Y1UU28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_647623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874384.1">
        <property type="nucleotide sequence ID" value="XM_022017688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU28"/>
    <dbReference type="STRING" id="4999.A0A1Y1UU28"/>
    <dbReference type="GeneID" id="33559497"/>
    <dbReference type="InParanoid" id="A0A1Y1UU28"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="504"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="718"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1250"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1186"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1270" mass="140782" checksum="3732E407BF2E699A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUF0</accession>
    <name>A0A1Y1UUF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carboxylic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_612178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874494.1">
        <property type="nucleotide sequence ID" value="XM_022014364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUF0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUF0"/>
    <dbReference type="GeneID" id="33556172"/>
    <dbReference type="InParanoid" id="A0A1Y1UUF0"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="496" mass="53977" checksum="01D4530A83DA0725" modified="2017-08-30" version="1">MASITSTVWASLPRLPAKSERVIQRNPIKLIRSLTWLQFAFFFSGWFAWVCDAIDFFAVTLSAARLAPYFHKTLSTVTLSITLTLLFRPLGAFIFGMLSDRYGRKWPLVANLIIISALSLATGFCKTFSAFLACRSLFGIGMGGIWGLAVSMALENMPVDARGLFSGFLQLGYPVGYLIIAAVNLNSRVAKETGWRPLFYTGAAFSLTGAIIRLLLPESQYFLERQAARQREGDQTATSKKSVQFIRETWKMLKTHWARCIFAIVLMTGFNFYSHGSQDLYPAYLTNDKGLTSHQATVATIIGNCGAITGCTIGGYVSQYLGRRITMICFCLFCCAMLPLWLLPSSFSGLAAGAFLVQAGVQGAYGVVPVYLSEISPVAFRAMWPGVAYQIGNMVSSASAQIEATAGAKLKDPKTGKPAYGRVSAILVGVAAGVVILCCLFGDESHSAHFERGRAAFEKDGGLDVVDDGQAAKTYPESTQGDEEKAEDIQRDHLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UV61</accession>
    <name>A0A1Y1UV61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_648000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874784.1">
        <property type="nucleotide sequence ID" value="XM_022017762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UV61"/>
    <dbReference type="FunCoup" id="A0A1Y1UV61">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UV61"/>
    <dbReference type="GeneID" id="33559571"/>
    <dbReference type="InParanoid" id="A0A1Y1UV61"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="199" mass="21853" checksum="60A9E2D6147D4A78" modified="2017-08-30" version="1">MALPIQNLMDMGSMDHGSSSSMNDSSASSMSMSMGDGCKISMLWNWYTVDTCFLSATWHNKTRAMFAGSVIGVFFLTIAIEFVRRLGREFDRRLVAAARVRASLGQSTSAPNSEDNLNKNLGSAEGTSFVYTPTWGHQVLRGLLYGSQFAAAFLVMLLGMYYNGYMLFAIFLGQTTGYIIFGRDTCTCTIDHVTTGHCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UVH4</accession>
    <name>A0A1Y1UVH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_613663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874894.1">
        <property type="nucleotide sequence ID" value="XM_022014525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UVH4"/>
    <dbReference type="FunCoup" id="A0A1Y1UVH4">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UVH4"/>
    <dbReference type="GeneID" id="33556333"/>
    <dbReference type="InParanoid" id="A0A1Y1UVH4"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX41215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="426" mass="47945" checksum="B7808E593A1BC51A" modified="2017-08-30" version="1">MADSPEERAHWRAVLKAYDGYMQYHLSANHARRMAFLQLPKEDKEVYEHLGFREKLEAVDEGIRRNAEFIDEMIADPLFAEMIKEPDDEDHGSHTHGYTHGAHSHSHGDFHSHDHGHGTASHHPQSTAKQRHENDVAQDKVRSTLRSFVRDWSKEGKTERETCYVPILEALERLCPLDKNGESSHRPRSHIRVLVPGCGLGRLAMEIAAAGFSSQGNEFSTYMLLASHFVLNQTTAPDTYTIFPFLHSFSNHLTTSNHLLRRVHIPDVCPAQVLGSRSGGDFSLIAGDFEDIYGPSSWDTPSDVTMGGDGQGQRGRWGAVVTCFFLDCARNPLTFLRIIYTILEDGGVWINLGPLLWHFENSPTVSAAGDRSIELSLDEVKELARVVGFDLHEEKLIETSYTGIPDNMLRNTYTAAFWTARKRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5E5</accession>
    <name>A0A1Y1U5E5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_585299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000030">
        <property type="protein sequence ID" value="ORX33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867615.1">
        <property type="nucleotide sequence ID" value="XM_022013735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5E5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5E5"/>
    <dbReference type="GeneID" id="33555543"/>
    <dbReference type="InParanoid" id="A0A1Y1U5E5"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="304"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="59425" checksum="57E52655135F95FE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5H1</accession>
    <name>A0A1Y1U5H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_289916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867639.1">
        <property type="nucleotide sequence ID" value="XM_022012392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5H1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5H1"/>
    <dbReference type="GeneID" id="33554200"/>
    <dbReference type="InParanoid" id="A0A1Y1U5H1"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000046">
        <property type="entry name" value="Drebrin-like protein isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="170" mass="18067" checksum="C223097E89E1FF49" modified="2017-08-30" version="1">MASRPGPAAPPAGQKAKAVYDYEAAEEGEIGFADGEILTQIEQLDEGWWSGTNANGQSGLFPANYVELIEDDGPAEGEAPPAAPPPPPAPPAPPAAQAANREAEEEEEGEVMVAQYDYDAAEDNEISFKEGERITNIDKVDADWWQGTNNGKTGLFPAAYVCAPDEYQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5Q9</accession>
    <name>A0A1Y1U5Q9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_284732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000023">
        <property type="protein sequence ID" value="ORX33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867710.1">
        <property type="nucleotide sequence ID" value="XM_022012374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5Q9"/>
    <dbReference type="GeneID" id="33554182"/>
    <dbReference type="InParanoid" id="A0A1Y1U5Q9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="32162" checksum="C140FBCD8BEB7518" modified="2017-08-30" version="1">MNIAAMFYGYNEDYCRALYPLLTPRYDTTWAKLYPRLVSTCITALPLLCRFTDYTEPSVTISDDSAICKDYVHIPMDVLAGSYHVASNPLIAVLIRMRVLFNSIRSLNLQDQSLRLAQTLLGYWSEEEDVEIEEDEDYPTVPCIYWDTTDGLHRAAFALALYHNFVRSFVYPGSLPSSLEQVAWSIMKRTQRLRKTLKDQGWSHGSVHDMDNVVKLQSGVRIPGDWFECKDQGGGTKPYQASSFAVASSVAYRCPSDPGKYLRLPIHSPHHQRDSGSDRQFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5S4</accession>
    <name>A0A1Y1U5S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_639936</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867727.1">
        <property type="nucleotide sequence ID" value="XM_022017299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5S4"/>
    <dbReference type="FunCoup" id="A0A1Y1U5S4">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5S4"/>
    <dbReference type="GeneID" id="33559108"/>
    <dbReference type="InParanoid" id="A0A1Y1U5S4"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="59"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="202" mass="21735" checksum="E0A7D72A0D9A0127" modified="2017-08-30" version="1">MANLSLYTITALLILDSDGNRVLAKYYAPPHQTALGTGITADLGVGPGGPGMPGLGSLKEQRAFEKNVFEKIRRGGGEIHPLPPHLILTRQSTDLTFILVGPLNSSNELMLHLTLTAFHDAVSLLLRGQVEKRNVLEGLDMVLLAADETVDDGIVLETDAAAIAARVSRPKADTTDIVINEQTLMSAYSTLKERVTQRIGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5W7</accession>
    <name>A0A1Y1U5W7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_639749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867766.1">
        <property type="nucleotide sequence ID" value="XM_022017280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5W7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5W7"/>
    <dbReference type="GeneID" id="33559089"/>
    <dbReference type="InParanoid" id="A0A1Y1U5W7"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="186" mass="21063" checksum="E088C18B11818CDF" modified="2017-08-30" version="1">MGKRKAASKQPTKKKSEPLATTFKCLFCNHEKVVSVKLDKQTMFGKLDCKNCRQYFQTPINNLSAAVDVYYDWVDACEEARARQPPKQRPIRGPGPTEVGPVSMDFESRRRLAANKDAEDEDEDAEGDEDEEDDVDDRPVSKNNAAPARRAPADYDDDDEDDVDDVDDERGDKRRRADLDSEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U658</accession>
    <name>A0A1Y1U658_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_639625</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867840.1">
        <property type="nucleotide sequence ID" value="XM_022017256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U658"/>
    <dbReference type="STRING" id="4999.A0A1Y1U658"/>
    <dbReference type="GeneID" id="33559065"/>
    <dbReference type="InParanoid" id="A0A1Y1U658"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="233" mass="24853" checksum="0A5FFDAC914703CD" modified="2017-08-30" version="1">MDSPLLPTFKHGAEDTTNLLSDLSIADSPQSHASGSKSRFSFLPRGDQDGQSSSRDDVLRESLYELKQMNEVFDGFLGALEAARGHNLRLQTRVRETHALLDNYTALLGQTEHAQRLILNSAWTGAQDDDAAIEAEQQAQRVAEAAAALEPERKAEAAKLAEERKAAVVASQDKAKDLGTLGRGGSRIPSRGRGGPPPSRTTSASSGIRKPSDGLGGKYASVRSSGYGPRKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6S1</accession>
    <name>A0A1Y1U6S1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868038.1">
        <property type="nucleotide sequence ID" value="XM_022018706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6S1"/>
    <dbReference type="FunCoup" id="A0A1Y1U6S1">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6S1"/>
    <dbReference type="GeneID" id="33560515"/>
    <dbReference type="InParanoid" id="A0A1Y1U6S1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="348" mass="39345" checksum="9F804EF3294773B8" modified="2017-08-30" version="1">MMEYVNLGKSGLKVSHLDALRVTLTSLWVSKLVLGCMTYGSGGEWMISDHDESIRQIKYAYDKGINAFDTANTYSAGESEVILGKFLKQHNIPRESVVILTKTFNTDGKLEDKGPAGWINQKGLSRKRIFASVDDSLKRLQLDYIDVLQCHRFDPETPVEETMQALHDVVQSGKVRYIGMSSCWAWQFQLMQTYAIHNRLTPFISMQNQHSALYREEEREMMPMLKHYGIGVIPWGPLAAGLLCRPPQERKATPRGDKGLPNDGRGTFPSELEIIARVEKVAKNRGVPMAEVAIAWSLQSEWVTAPIVGVRSTERLDELIKGLQCRLTEEEIKEIGEPYQPVKVRGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U738</accession>
    <name>A0A1Y1U738_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_638868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868148.1">
        <property type="nucleotide sequence ID" value="XM_022017165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U738"/>
    <dbReference type="FunCoup" id="A0A1Y1U738">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U738"/>
    <dbReference type="GeneID" id="33558974"/>
    <dbReference type="InParanoid" id="A0A1Y1U738"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="4">
        <location>
            <begin position="306"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="443" mass="49340" checksum="26562D3D839A4A82" modified="2017-08-30" version="1">MQQLEAGQELLTWLRDAGGLVHPALELRMDEDTGLSAFTSREVGAAEQLISCPFDLAITIEVATGAICSIYGIQESELHEWNERMRIVTYLVLHHVHSGSSDWPEALGHLKYVNSLPSADLLLTPLHYSEPELELLQGTNMYGAIEAQRALWKSESERINEAVKDPRLTWDLYLLSATHYQSRAFPSRLLKLATTSTYVNAIPEPSTEDESYPMLLPGVDIFNHARGQPVTWLSTSIPSAEGSCPSVVVLDRGGIREGVQVFNNYGPKSNEEFLFSYGFVLDPNPDDTVTLKVSSGGMTPEGEARLKERRLDANRKFVLRLDSPVPQDLLRMLRVVLGEEVEVDNNGEDEDDLHAEHEREVKTVELELDVLGLLGSMLEDKLAKLPPMKEDSTGVREEVARMCRVYVQGQSDILSNTITTVIDKIDQLENMLDQGMGECPCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U789</accession>
    <name>A0A1Y1U789_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UNC-50 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_637627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868179.1">
        <property type="nucleotide sequence ID" value="XM_022017025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U789"/>
    <dbReference type="FunCoup" id="A0A1Y1U789">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U789"/>
    <dbReference type="GeneID" id="33558834"/>
    <dbReference type="InParanoid" id="A0A1Y1U789"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="259" mass="28939" checksum="F6A3F88D99E7EDB1" modified="2017-08-30" version="1">MANSILPLSSGSSRQDGHSFAFQKSGGGLPTMLRRLTKFRTMDFELAFWQLTYLVVAPRRVYKQTYHHKQTKNVWARDDPAMIVLISSSLVVAGLAWSLVYRESMAGTIYTILRMIMRDFILASVIIASLLHFLANRLLVSSASSPAIDNRVEWAYAFDVAVNSFFPLFLTLYGALLPLAPVVVKSNFVCLFIGNTLFLVAGIQYTYVTYLGYAALPFVARSELFLAPLLPIFGGYLLSLLGVNIARLTLELYFGKPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7W7</accession>
    <name>A0A1Y1U7W7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_683542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868380.1">
        <property type="nucleotide sequence ID" value="XM_022019192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7W7"/>
    <dbReference type="FunCoup" id="A0A1Y1U7W7">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7W7"/>
    <dbReference type="GeneID" id="33561001"/>
    <dbReference type="InParanoid" id="A0A1Y1U7W7"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="734" mass="80382" checksum="BCF688A8439E3388" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U827</accession>
    <name>A0A1Y1U827_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_643534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868440.1">
        <property type="nucleotide sequence ID" value="XM_022017554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U827"/>
    <dbReference type="FunCoup" id="A0A1Y1U827">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="GeneID" id="33559363"/>
    <dbReference type="InParanoid" id="A0A1Y1U827"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="901" mass="97782" checksum="A0396AC1C3866330" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8H7</accession>
    <name>A0A1Y1U8H7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_653579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868596.1">
        <property type="nucleotide sequence ID" value="XM_022018673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8H7"/>
    <dbReference type="GeneID" id="33560482"/>
    <dbReference type="InParanoid" id="A0A1Y1U8H7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="730" mass="81944" checksum="D444A76900957D90" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8R1</accession>
    <name>A0A1Y1U8R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868693.1">
        <property type="nucleotide sequence ID" value="XM_022018628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8R1"/>
    <dbReference type="GeneID" id="33560437"/>
    <dbReference type="InParanoid" id="A0A1Y1U8R1"/>
    <dbReference type="OrthoDB" id="2573290at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="569" mass="62254" checksum="EB2C9B9F713D8CA0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8U0</accession>
    <name>A0A1Y1U8U0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_653220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868706.1">
        <property type="nucleotide sequence ID" value="XM_022018630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8U0"/>
    <dbReference type="GeneID" id="33560439"/>
    <dbReference type="InParanoid" id="A0A1Y1U8U0"/>
    <dbReference type="OrthoDB" id="2596987at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892157" evidence="3">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="400" mass="41472" checksum="116D3666B971B677" modified="2017-08-30" version="1">MLVLIRTILSSILLSLAIAHSNSSPTLTGTVETLTTSRRPLLLPTATYTSHEPISETSEQRSVTTPARIAPISIAGSSPWLHPLALVLLLLAFLGFISTLDALPFQIMPSSSSAPKPSSSSSSSKERPSSSKDRPTSSSSSSSRPSSSSSSSSSSAKPPQATPYITANAWMSFFLFVCLVLIILQGPLGLTGGSGLGNFWPGSPSWCAGNLGASVPWCQTYPPYPPAAGYVAPLGKAIPMVGSPLSPPIAVTPVIQVQQAQAPQVIVHDQQQQMPQVGGQGIIATPGGEGGYSWYANPPQTPRQARVRPQGVNVQYQRPGLQIQVSNGESKPVQQIQHQNGATVPLMPVAVAAAPAVAPAVPAVPVSPGSPPAALGNVENAFYPLLVGAIALLVIFDYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Y1</accession>
    <name>A0A1Y1U8Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_636044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Plays a central role in virulence and antifungal drug action.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868731.1">
        <property type="nucleotide sequence ID" value="XM_022016860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Y1"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Y1">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Y1"/>
    <dbReference type="GeneID" id="33558669"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Y1"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="175" mass="19750" checksum="7F319DDD26A85D58" modified="2017-08-30" version="1">MGQAESSVFNSLERTSNFSAEELMRLKKRFMKLDKDGSGSIDKDEFLQIPQIANNPLAHRMIAIFDEDGSGTVDFQEFVGGLSAFSSKGGRDEKLRFAFKVYDMDRDGYISNGELYLVLKQMVGNNLKDQQLQQIVDKTIMEADKDGDGKLSFEEFTNMVASTDIVKQMTLEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Z3</accession>
    <name>A0A1Y1U8Z3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_646845</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868766.1">
        <property type="nucleotide sequence ID" value="XM_022017631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Z3"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Z3">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Z3"/>
    <dbReference type="GeneID" id="33559440"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Z3"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="233"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="467" mass="51653" checksum="93559BA68DB2E172" modified="2017-08-30" version="1">MKASEKKLRIGFIHPDLGIGGAERLVVDAAVSLQKRGHNVTIFTSRHDPKRCFEETRDGTLRVHVLGGRMLPMRLHPRLPMTIVFSILRSLLLTLLLCLSLLMPEPATFLNPLSPLEPFDVFIVDQQSVCVPVLRLVAGTRVVFYCHFPDKLLSAGWSIAADGTVKQKADLVRKLYRWPADKLEEWTTGQSDVILANSQFTSRVYASAFPSLRKRPPKVVYPCIDLSNYDKARKTSLTDSRPTLLSLNRFEAKKNVELAIRSFHALKTLVPEKFAEMRLVIGGGYDDAVPDNVTTLAHLRAECRELELDQVEFLLNFTATERSALLNNPNTLCLLYTPTNEHFGIVPIEAGACGLPVLAVNSGGPTETILDGKTGFLREPKTDAWAEALANLVTLSPTRRKEMSKTAKERVTSLFSLDTLGRHLEESCREALGKGVLSDQLGDKLIWSGVCLIGMSLVAIAITVALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U910</accession>
    <name>A0A1Y1U910_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_638071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868312.1">
        <property type="nucleotide sequence ID" value="XM_022017079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U910"/>
    <dbReference type="STRING" id="4999.A0A1Y1U910"/>
    <dbReference type="GeneID" id="33558888"/>
    <dbReference type="InParanoid" id="A0A1Y1U910"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="832" mass="91059" checksum="9C67064B14A02B6C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9X1</accession>
    <name>A0A1Y1U9X1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_635456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868607.1">
        <property type="nucleotide sequence ID" value="XM_022016811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9X1"/>
    <dbReference type="GeneID" id="33558620"/>
    <dbReference type="InParanoid" id="A0A1Y1U9X1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="115" mass="12064" checksum="0F67F3AA5951EC7C" modified="2017-08-30" version="1">MRPQESSGSTSDEAGLRSYLVQPGRIEGSFTHSLCDDTHGRSSNRPAGVLGVDWSVSGDDAHGGSSDRPAGVLGVDWSVSGDDTHGGSSDVLTDVFEVDGSHCKSWAVFVKKAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Z1</accession>
    <name>A0A1Y1U9Z1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_653594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868183.1">
        <property type="nucleotide sequence ID" value="XM_022018676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Z1"/>
    <dbReference type="FunCoup" id="A0A1Y1U9Z1">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9Z1"/>
    <dbReference type="GeneID" id="33560485"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Z1"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="248" mass="27217" checksum="6CADC9B6B570C061" modified="2017-08-30" version="1">MSDYQVTLVNNKMSEFFVKFYGPAETPFAKGVWKIHVELPEQFPYKSPSIGFMNKIFHPNIDELSGSVCLDVINQTWSPMFELINIFEIFLPQLLRYPNPSDPLNGEAAALLMRDPKAYAKKVESYVERFAMPEDADQARGGDDEDEDEEEEELGPKRAANGETSRPKAPTRGIAAPASTNTHSNGSNGHASAAAGTSNGHAKSTSGGINGTSHHDDGEEEEDDDDDDKMSDMGELSDGDEFMGEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ3</accession>
    <name>A0A1Y1UAJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_633767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869274.1">
        <property type="nucleotide sequence ID" value="XM_022016659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ3"/>
    <dbReference type="GeneID" id="33558468"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ3"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="79" mass="8472" checksum="49A3D7B2D2A139B0" modified="2017-08-30" version="1">MSDNNKNEEQQFNILPHPAKTNNPADLVSDPAGQGGLQGSGPNAFNAKEPHIPSQAVAQGLEQPKTRDELKAEAEKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAW0</accession>
    <name>A0A1Y1UAW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL46 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_583915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868493.1">
        <property type="nucleotide sequence ID" value="XM_022013645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAW0"/>
    <dbReference type="FunCoup" id="A0A1Y1UAW0">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAW0"/>
    <dbReference type="GeneID" id="33555453"/>
    <dbReference type="InParanoid" id="A0A1Y1UAW0"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="256" mass="28659" checksum="15DB93A3A8297C3F" modified="2017-08-30" version="1" fragment="single">SSSIPPPLRASLILSRHPLIRRTPSTLELTYHAHSSALRRAISNPVPENVYFSKGSLAHRRFQKAEYEREKEAFGAAIAGTPPAVGDIPPERPLEILERDHWAKLDAERGERSLERHPDQEIFCLIKEKESKKWEFPTRTLKENDSLHTAAEQITGVGGILDGQTMDTWLVTKKPVGLTQKDGQRTFYLRSHILGGEPKLSSSGPWSDLAWLNLSELEERLKAQGDEPLWDGVKAIFGVPKIPTSELGFDEASLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB29</accession>
    <name>A0A1Y1UB29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_130211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868969.1">
        <property type="nucleotide sequence ID" value="XM_022011983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB29"/>
    <dbReference type="FunCoup" id="A0A1Y1UB29">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB29"/>
    <dbReference type="GeneID" id="33553791"/>
    <dbReference type="InParanoid" id="A0A1Y1UB29"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1122"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124378" checksum="1D789058BC9DC525" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB33</accession>
    <name>A0A1Y1UB33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab-GTPase-TBC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_84724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869438.1">
        <property type="nucleotide sequence ID" value="XM_022019266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB33"/>
    <dbReference type="FunCoup" id="A0A1Y1UB33">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB33"/>
    <dbReference type="GeneID" id="33561075"/>
    <dbReference type="InParanoid" id="A0A1Y1UB33"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="50"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="35524" checksum="0DBC40072BEF234C" modified="2017-08-30" version="1">MTQSEVYNQLSSLLVPTSASHSRHRTTSEISDGLKRIRRLILTEGIPYEDGKASLRPAIWKLMLRIDSLHAEDYLRYVAMGPSEVSTKIKNDTFRTLATDTQFKGKVKEDMLIRLLEAFVWKNHGSERDGLPFTYVQGMNVLSAPFLYTMPSQLEAFACFSTFIEKCCPLYVQPTLTGVHRGLKLLDRCLKIVDTELYDHLRSKNLSAELYAFPSVMTLCACTPPLDAVLRLWDTRSPSRSFLLAFGVHLNILCVIAQLILMKNELMESPSPMKILRTFPPLDVKRVIDITLVLVGEIPEELYRELVAHPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBB7</accession>
    <name>A0A1Y1UBB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_652465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869521.1">
        <property type="nucleotide sequence ID" value="XM_022018498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBB7"/>
    <dbReference type="GeneID" id="33560307"/>
    <dbReference type="InParanoid" id="A0A1Y1UBB7"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28574" checksum="91141020569281CB" modified="2017-08-30" version="1">MSFSPSAGQRSMDQAIQKYNGKPDILTGEYSNLTIVLKKTSERGNLGHLFITTVDPQGHYVSLLVHPPPEHESREVRIQFDPPLKSPWEVKAIFEQWEAEAKRNFKIPDNLPINYYSPPPLFPMTVPVIIGLSALIFADMGRGHYAEMFRAWIVRVFGKYMIRGAEIFAAFMHLLSEPVWMLVLLRRHQTPWSEGWKWVLTVMLLGAAGVSEFNDCVEYERLSYIYSQTEVGPLPPRLERKASPKVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBH8</accession>
    <name>A0A1Y1UBH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter transmembrane region 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_582251</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869590.1">
        <property type="nucleotide sequence ID" value="XM_022013551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBH8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBH8"/>
    <dbReference type="GeneID" id="33555359"/>
    <dbReference type="InParanoid" id="A0A1Y1UBH8"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="460"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX35400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="714" mass="80060" checksum="511CDACEE13BAE8E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBL3</accession>
    <name>A0A1Y1UBL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018525.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="33560334"/>
    <dbReference type="InParanoid" id="A0A1Y1UBL3"/>
    <dbReference type="OrthoDB" id="2594643at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="586" mass="64208" checksum="C30355ACF587DAC5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC91</accession>
    <name>A0A1Y1UC91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_120107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869360.1">
        <property type="nucleotide sequence ID" value="XM_022011954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC91"/>
    <dbReference type="GeneID" id="33553762"/>
    <dbReference type="InParanoid" id="A0A1Y1UC91"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="198" mass="21529" checksum="5FC9E9E43D1B963A" modified="2017-08-30" version="1">MLSFLPSWHTVSERESSRVNKVAPFLPSTSSVRYKPLSSAELYAAVPRPLATIATIHHPSHPNDKLPYSGKFETGKQGVSHPNPPRSCHSIHQPQPLLLVDRFATCVCLCIIRTCEGPFLVLIHLIRLPQSTNQPTTSSKEENGGDTAKNYSRPIASREVTHTTSIFKTLLFTGTSHILCLSLSLCDENAGKGGGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC96</accession>
    <name>A0A1Y1UC96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_633933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869332.1">
        <property type="nucleotide sequence ID" value="XM_022016681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC96"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC96"/>
    <dbReference type="GeneID" id="33558490"/>
    <dbReference type="InParanoid" id="A0A1Y1UC96"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="49255" checksum="91D21AA15731CC8D" modified="2017-08-30" version="1">MDADPWADAPATPKMDGRTPVPSPQKQTDSTSATHSTPGPSSPIAESEDVDSTHVDPDEPATQMVDSPIEDIPAAPIVAAGQPAEEDADFDDFVDFDEPAAGPSSFGASAMTDGDDGFGDFGDFEGGDESVETFGDQSGTVGVQPMQEPRDWAALHLDPFPSRSALRDQIASLLSPLMAESSGSSSRLTDEPPREVAGLGQIMVSESSREAYAQLTTAPILRSLDWTRSRVRREHLISMGVPVNLDEVDSHRLSSLPPLRISTTLPSSSSSRANHPSSSSRSGKGEMLPPAVPRPASVDGRRSTRSPAGESYSNQRSSTGDRGNGISPNHTGPKNASQRNRRDQNGMGPKPVLDTSQAEELCGLDEDALSLYSLERLRTIQNELVETSAQASALLAWYLQLKDAQTQDAETYNGMISELIANAAKAKQAQTSGSGGVFRRSSLKTRPQSSSGSATPGRIGSPAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCG0</accession>
    <name>A0A1Y1UCG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_74013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869895.1">
        <property type="nucleotide sequence ID" value="XM_022019232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33561041"/>
    <dbReference type="InParanoid" id="A0A1Y1UCG0"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="1258"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1409"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="962"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1420"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1439" mass="157609" checksum="FD26489A938BF3E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCZ3</accession>
    <name>A0A1Y1UCZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_652518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869576.1">
        <property type="nucleotide sequence ID" value="XM_022018511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCZ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCZ3"/>
    <dbReference type="GeneID" id="33560320"/>
    <dbReference type="InParanoid" id="A0A1Y1UCZ3"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013322233" evidence="4">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="272"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="448" mass="46016" checksum="B875624CBD926DED" modified="2017-08-30" version="1">MFTLLFLLGLLLSPTSRPTSAATTLKLRKSSSRSPRILHSLRRNSPRSPQRGGWRGGGGAGGGGRGGRYANVVVVTQSAIEGGSVVETVSTTQAIGEGGWYGKGRGGLAGDLVTTSAEVAASDTEIVDDADWGGGRGRWRMNNVQTDADSRDTSSYVYASSTGDLTGSTTRWIDDADSWTDSMVSTSTLDIITSVYISSTSPTAISSPPTSSAVSSLPTSLSSSAVSSASAAPTTTSFSALSSSSTSSSISSSPTGPATVGLDSQNSQGITYTVEVVIDGKKMEVIADTGSSMLWVPTTGCPTCSSAGMTISSITLPDDCSEYEQKYGMGSAVGCRTNVTVSLGDLELEDLSILGVKSVDSILAQQGSFMSGIIGFALDAGTIGDSPTFVSQLYNSGKIDSPEVGFYLPRGANQDGSVTLGSAARQVFVLTLELTSTALMRMPIQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCZ5</accession>
    <name>A0A1Y1UCZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidyl-prolyl isomerase CWC27</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptidyl-prolyl isomerase cwc27</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Rotamase CWC27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_629545</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870050.1">
        <property type="nucleotide sequence ID" value="XM_022016222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCZ5"/>
    <dbReference type="FunCoup" id="A0A1Y1UCZ5">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCZ5"/>
    <dbReference type="GeneID" id="33558031"/>
    <dbReference type="InParanoid" id="A0A1Y1UCZ5"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000007">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CWC27 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="17">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="192"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX35921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="484" mass="54151" checksum="8A4BFB463ED7F6EB" modified="2017-08-30" version="1">MSNLYVTEPATNGKIIIDTTAGEIEVELWGKEAPKAVRNFLALTMEGYYDGVIFHRIVPGFIVQTGDPTGTGMGGESFYGEPFQDEIHGRLKFHRRGLVGMANSGKRNTNTSQFFITLDRAEELTGKHTLFGKITGNTVFNVLNIGNLEIDDTERPKIPPKIRGIRIVENPFDDIVPRITVAEKKAQAKARAEAKKEAEAREKRSRAKKNTGLLSFGEAEEIPDDPQSSAKKNMGRRDLVETAGESSSKATPPRAQPNLVELPPSLHDLAESSSKPREKKIVDIREIRAQHDREKQGDSAARQAEIKKMQEDLRKLKKKSGQASDSDSDSDAGRRRKKVSYLDEELAKYSKGRGRAAKSGNRRSRKDEEDDLLLEMGRFSKRVAMAGDDDEGAQEDEDMPEPAQDLSLLGGPPNEELEVDDDVGWLKHKLRFVVDEKELTRRAEEEYAVIDPRAKARQLASEEKREKDNRFKGSRTAGDVGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD57</accession>
    <name>A0A1Y1UD57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_511567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870048.1">
        <property type="nucleotide sequence ID" value="XM_022012962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD57"/>
    <dbReference type="FunCoup" id="A0A1Y1UD57">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD57"/>
    <dbReference type="GeneID" id="33554770"/>
    <dbReference type="InParanoid" id="A0A1Y1UD57"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="367" mass="39220" checksum="977E65678EBAE42F" modified="2017-08-30" version="1">MPSVASSPSVLAPPSFDTSPPSMETFGTSTLPEGSDASSRRQRITMACQYCRHRKIRCCGGSPCRNCARSQRECEYAPVPEEVNRATREKKAMAKAAKSHSVSGSITPASGCSPAASSAPYYYPNPSPYFTDTPVFEGPYMAGPHPTSSPMNSRPSDFAHRRSFSVPNFELQSWAEGTPSAPQLHSPAMFESPQWMQHGGWSPSTHLSPASSPYPSVLERPMRHLAIHTGTNTSANSTPGSTSSYIPGKVEEMPPLPAAWSASQSMSHSTPVSPVYYTPQPTPGGPYHTNTQGQSPYFAQPAYSRHHSAAVINLNADSSPTLAPEMDSSSSGKELVGLGLGVPAARYDPYGPAHTLSEEYFAAQAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDM1</accession>
    <name>A0A1Y1UDM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_657049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870231.1">
        <property type="nucleotide sequence ID" value="XM_022018854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDM1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDM1"/>
    <dbReference type="GeneID" id="33560663"/>
    <dbReference type="InParanoid" id="A0A1Y1UDM1"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="6">
        <location>
            <begin position="444"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="982" mass="109120" checksum="DA9D51ECB8DC31E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE33</accession>
    <name>A0A1Y1UE33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_581987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869938.1">
        <property type="nucleotide sequence ID" value="XM_022013534.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE33"/>
    <dbReference type="GeneID" id="33555342"/>
    <dbReference type="InParanoid" id="A0A1Y1UE33"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="918"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="761"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1295"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1491" mass="158706" checksum="8640496AEEE64D24" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE83</accession>
    <name>A0A1Y1UE83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_490479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870454.1">
        <property type="nucleotide sequence ID" value="XM_022012931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE83"/>
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    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="4.10.1000.10">
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        <property type="match status" value="3"/>
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        <property type="entry name" value="ZFP36-like"/>
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    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
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    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="991"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="711"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="837"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="955"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="96"/>
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    </feature>
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        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
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        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
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            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="523"/>
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        </location>
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        <location>
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            <end position="741"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="859"/>
        </location>
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        <location>
            <begin position="957"/>
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        <location>
            <begin position="974"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1120" mass="120471" checksum="FF880C39293B224D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC5</accession>
    <name>A0A1Y1UEC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_642561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022017494.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UEC5"/>
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    <dbReference type="OrthoDB" id="61390at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012192159" description="S-adenosyl-L-methionine-dependent methyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36321" checksum="8D12FD54AC31E33C" modified="2017-08-30" version="1">MMHPLLIGVACLPLLFRLVPMIVPEHYLEPYAYWNAGTLNEQDGKIETYWRNMGYWDGIDSYSEAAGTLARKLLEFADAEPGGAILDIAHGAGESLSMHLNSSRPPSHLDALTSLPSESRFAKDLIAHRHPNMETVTNFFTSSASYRPGKDLQHPLNPMRGFMGDRRPSDEGLEPLAPPYHLVYILDAIYHFRPSTAHFLSHVIHVLKPSGVIAFTDILPPSNLSPFLGHLILPPLLSVPARNLVSKTRTVEGYHELMQKIGYKNVKIEDWSDHVFPGLANHLRSRGRLWTLVAKGIEWAERGGWKFVAVRASRSAVDHRLSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC7</accession>
    <name>A0A1Y1UEC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_651780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869993.1">
        <property type="nucleotide sequence ID" value="XM_022018393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEC7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEC7"/>
    <dbReference type="GeneID" id="33560202"/>
    <dbReference type="InParanoid" id="A0A1Y1UEC7"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="153"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="385"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="581" mass="63899" checksum="5C5ED00D9617F315" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEF3</accession>
    <name>A0A1Y1UEF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_628849</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870541.1">
        <property type="nucleotide sequence ID" value="XM_022016150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEF3"/>
    <dbReference type="FunCoup" id="A0A1Y1UEF3">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEF3"/>
    <dbReference type="GeneID" id="33557959"/>
    <dbReference type="InParanoid" id="A0A1Y1UEF3"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="67"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="410"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX36440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="607" mass="64908" checksum="7D3DD5DF129A783A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEJ5</accession>
    <name>A0A1Y1UEJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_580682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870582.1">
        <property type="nucleotide sequence ID" value="XM_022013453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEJ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEJ5"/>
    <dbReference type="GeneID" id="33555261"/>
    <dbReference type="InParanoid" id="A0A1Y1UEJ5"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="92"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="576" mass="63357" checksum="5ACF934E36086B61" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEN3</accession>
    <name>A0A1Y1UEN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_504781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012954.1"/>
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    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="134" mass="15030" checksum="D5AEA2838C46DD64" modified="2017-08-30" version="1">MRASLRRLQERYCHSALLSSLCLAQCTRPSARHIRPTRAVPFVRRTDRRLSTSTVLPQLHIKLTVVHRTTRSEDNDGIGKPEVTESIGDPAKTESGRSNMPKAAWYAVHTGRRPGVYSSWSEAEAQVKGFNGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEN8</accession>
    <name>A0A1Y1UEN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic mitochondrial regulator protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_497994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870550.1">
        <property type="nucleotide sequence ID" value="XM_022012947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEN8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEN8"/>
    <dbReference type="GeneID" id="33554755"/>
    <dbReference type="InParanoid" id="A0A1Y1UEN8"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29463" checksum="0F390181BB469B24" modified="2017-08-30" version="1">MVMAKTTRIPFLVAGPSGWEDAFFRPPPPLSNAVQDRIYTQLQQGDKDVATLASEYCISKARIHAIHKLKQVEAEFRRQSLPLQEAFQYGMEPLLDMKSPIDPSTRQYSERSAREEARARASDVSHQTEIVEETRWENGQGAEGSFGEPIQGLDNRRVEGLAWEWRDEETMGEIQPDRFTLPKRAQRERRDTSVVAPAQLLPAQGSKSAIRFIDMSKVGIPQEVQVARRLQSRAHQTSKRKARRDDVRRRASSPAPKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEP9</accession>
    <name>A0A1Y1UEP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869709.1">
        <property type="nucleotide sequence ID" value="XM_022018440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEP9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEP9"/>
    <dbReference type="GeneID" id="33560249"/>
    <dbReference type="InParanoid" id="A0A1Y1UEP9"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="24927" checksum="298D81AB3B349918" modified="2017-08-30" version="1">MPESIESDPNHYPKIQFRNPPFTFHRSLARFCIPLSKFTKLSSNQGKRIRASVVISEPYLPGTSNEGPGSSATTPFVSRLLVVQRSAHDAAFANNWELPGEHAEFGVDQTLLETVVRGTREKTGLRVTGIKRELKGLEYHLSGGGVSKQFVFWVDVQGLEGTRGVQSVQGSHMEGESMRTLIRLDPIEHQAWKWVSERDVDGLHTTAETKECILSALTVIGQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF20</accession>
    <name>A0A1Y1UF20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">BD324DRAFT_524472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF20"/>
    <dbReference type="FunCoup" id="A0A1Y1UF20">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF20"/>
    <dbReference type="InParanoid" id="A0A1Y1UF20"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000045">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="243"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="421"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="455"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="550"/>
            <end position="551"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="556"/>
            <end position="560"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="633" mass="71163" checksum="423046F055F48C56" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF21</accession>
    <name>A0A1Y1UF21_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_626696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870729.1">
        <property type="nucleotide sequence ID" value="XM_022015923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF21"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF21"/>
    <dbReference type="GeneID" id="33557732"/>
    <dbReference type="InParanoid" id="A0A1Y1UF21"/>
    <dbReference type="OrthoDB" id="42919at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF19">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="104" mass="11318" checksum="69089BE3E9A53F23" modified="2017-08-30" version="1">MGKVVHIVMWKLKQSAASAGSEGHKAATQAISALKTVPGPETMQLGPPLIDARAKGFNWGLYSVFASREALDKYTVSEAHVKVVTENVKPNIEDVMAYDFELDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF46</accession>
    <name>A0A1Y1UF46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator PAI 2-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_626643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870707.1">
        <property type="nucleotide sequence ID" value="XM_022015914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF46"/>
    <dbReference type="GeneID" id="33557723"/>
    <dbReference type="InParanoid" id="A0A1Y1UF46"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="242" mass="27169" checksum="5E8149CC792DBD92" modified="2017-08-30" version="1">MHLRHEHAVLDIPTLERFIRDNPLGLFTTSIPHPEHATLQISHIPFILDHADPESSSAGRLRGHIARANPQSKSILDLVRSIGRDELDEEVLIIFNAPVNGYVTPRFYTSTKPTSGKVVPTWDYAAVQVYGKLKVHQASTRESDEFIHQQMLDLNAWGEDTVPGDKWKLSDAPEQYLALRRKAVIGIEIQVTRMEGRFKLSQEREDGDWHGVVEGFKSLGTVQGDRLASMIAGCGKERTINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFS6</accession>
    <name>A0A1Y1UFS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_628534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870465.1">
        <property type="nucleotide sequence ID" value="XM_022016123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFS6"/>
    <dbReference type="GeneID" id="33557932"/>
    <dbReference type="InParanoid" id="A0A1Y1UFS6"/>
    <dbReference type="OrthoDB" id="3246235at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="307" mass="32240" checksum="E58FD0EC9BE99A3E" modified="2017-08-30" version="1">MPSCRITNHTAQPLNICLKQVTALHFENTVQPGQTIKFRPGKVWFTLEALVDDGTKKSRYSVLKSAATIAILSVAVGAVAATAGAALLPEAAALEAIAAASVAGSYLAKGMTVTKAALVSNSGTIAKISSTMLPKAIDKLTAEIGGLSALQREVLTIISSPSISSDVRHRATSLLKQLHGAYAKDKAEKRPGGASNNPNPIMDPTSKQMPAEAAPQSVTEGTGSGISSADPATDLGPLDEKEGAALEAELDAGKLDDRVEHTPIRTGEVLRVHGVYMNVKREFDIRVGAEGKLELWDAKANKRWGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFV0</accession>
    <name>A0A1Y1UFV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Supernatant protein factor, C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_627611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870967.1">
        <property type="nucleotide sequence ID" value="XM_022016019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFV0"/>
    <dbReference type="FunCoup" id="A0A1Y1UFV0">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFV0"/>
    <dbReference type="GeneID" id="33557828"/>
    <dbReference type="InParanoid" id="A0A1Y1UFV0"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012734001" evidence="9">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="169" mass="18983" checksum="053485C5744F8DDC" modified="2017-08-30" version="1">MILRSVHPLAVILALCWICNEITAHRIEIDPGEKACFYEQLQHKDRMSVTYEVGGATAGGHLDIDFYASDPTGKTFYSQYKQPTGSLSMEAASSGKYEYCFDNTMSTFSTKTLSFSVHGTLFSEDEEQIAPVEREIRNLGNSLQLVKDEQAYLVQREKIHRNTAESTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGP5</accession>
    <name>A0A1Y1UGP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavonol synthase/flavanone 3-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_459873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870743.1">
        <property type="nucleotide sequence ID" value="XM_022012843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGP5"/>
    <dbReference type="FunCoup" id="A0A1Y1UGP5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGP5"/>
    <dbReference type="GeneID" id="33554651"/>
    <dbReference type="InParanoid" id="A0A1Y1UGP5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="372" mass="41845" checksum="B2AB63E7817C2CE9" modified="2017-08-30" version="1">MAYSERVSELDFLHNTASLHTFKMTKPTVEIPIIDFEGLEDGSPEIAADIGRKFYAACREVGFAYIKNHGIPERDIQGMFDYSRRFFALPYDIKMTAPHPPAGDHHRGYSGVGMEQVSQMVFDEDKLEAMRNGKGGDFKESYDMGSETATHNPNIWLEDDYLPGLRAYSVAFQATCRALQMRTLRALALGMPEVPEDFFERYHTEGDNQLRLLHYPSAPRDVFDSGEKGRIGAHTDFSTCTFLFQDDCGGLQVESPRSPGVFIAAPPIPGTIIFNIGDFLMRWSNDSLKSTLHRVVAPPPREDETGMTRERYSIPYFCGANKSLTIETLPGTWSESKPKEYAPITAGEYVNMRLNATYEAGVKKLKKEALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGP6</accession>
    <name>A0A1Y1UGP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_626853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870766.1">
        <property type="nucleotide sequence ID" value="XM_022015936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGP6"/>
    <dbReference type="GeneID" id="33557745"/>
    <dbReference type="InParanoid" id="A0A1Y1UGP6"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8371" checksum="2A91C7C51275F683" modified="2017-08-30" version="1">MFGRLTRLTVDLVAISVLIAGVKKSTGYAPRTERIKDTALRRFFDSYFALGDTVFGMVCGFVVNSRYFKRTIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGQ7</accession>
    <name>A0A1Y1UGQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_628078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870356.1">
        <property type="nucleotide sequence ID" value="XM_022016081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGQ7"/>
    <dbReference type="GeneID" id="33557890"/>
    <dbReference type="InParanoid" id="A0A1Y1UGQ7"/>
    <dbReference type="OrthoDB" id="2562902at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21592" checksum="6D1BE4837F13E3D0" modified="2017-08-30" version="1">MPSVPFTDSRWTVLNPPEKDVSISEDGSTLKMISNHESDLYRTPKWEKYNASVYGFKHSLGKEGLTVSVDVELDHRDQYDQAGIYFHISNTLWFKFGLELNGDLFAGTVVTQPYSDWSLVPAKNHVPKTFTFTLHDKILMIYNDGVLAREVNCFGTGDETEAFVGVMTCSPKGGGITATFKDFKIDEGVIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGS1</accession>
    <name>A0A1Y1UGS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871299.1">
        <property type="nucleotide sequence ID" value="XM_022015803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGS1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGS1"/>
    <dbReference type="GeneID" id="33557612"/>
    <dbReference type="InParanoid" id="A0A1Y1UGS1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="717" mass="81329" checksum="BA9036308595FAAA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGU0</accession>
    <name>A0A1Y1UGU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_579800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871280.1">
        <property type="nucleotide sequence ID" value="XM_022013409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGU0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGU0"/>
    <dbReference type="GeneID" id="33555217"/>
    <dbReference type="InParanoid" id="A0A1Y1UGU0"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="416" mass="45528" checksum="FBCBD85D85B7A007" modified="2017-08-30" version="1">MPSSGSSADKMVFAHFMIGIVSTYTQQDHENDQSLAKSKGIDGFALNIGVDPYTQQQLTLAYAAAEAVGFYCFISFDFNWWSTGDTAGVANMLKQFISSPAAYKVDGKPFVSSFIGDGFNWGACAAAVGEPLYAVPFFQPTPSLATDDGLAGSFSWAAWPGQLDNVPVDQNMTISRDEDYMDILTPAGKTYMAPVSPWFFTHYGKEVSYSKNWLFYSEELWKYRWDQILQLGQKGVNLVEIVTWNDYGESHNVGPFNTPHTNDGAALWASGLSHTSMLDLSVPYIEAFKAGLPVPVVTQEFMVYWHRPTLKDVECDSTDNCGSKPTGWEYVADSVFVATVTKNGAMVTVTSGDNAPVTQKVSGGIQIFQVPMSAGDQQFSMKTSWGMSTSGSSNVTVLDTCWNGIYNFDFHSGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH06</accession>
    <name>A0A1Y1UH06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_625441</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871297.1">
        <property type="nucleotide sequence ID" value="XM_022015801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH06"/>
    <dbReference type="FunCoup" id="A0A1Y1UH06">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH06"/>
    <dbReference type="GeneID" id="33557610"/>
    <dbReference type="InParanoid" id="A0A1Y1UH06"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX37259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="131" mass="13912" checksum="8774D2F458BCCBCB" modified="2017-08-30" version="1">MAALRLALKSLPRAGSSSVLLAARPIAPLALRLPVPSLSLARGYAASAGLSKEDITQRIMEVIKDFEKVNAAKLSTSSSFTNDLGLDSLDSVEVVMAIEEEFGIEIPDDEADAITTVQQAIDYISQTPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH26</accession>
    <name>A0A1Y1UH26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_469705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870875.1">
        <property type="nucleotide sequence ID" value="XM_022012874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH26"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH26"/>
    <dbReference type="GeneID" id="33554682"/>
    <dbReference type="InParanoid" id="A0A1Y1UH26"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="28808" checksum="9CCCF811AA10B326" modified="2017-08-30" version="1">MLTIANDTTPPGLGEPLNLILSADSDAAVLVHSASNGGFLNYMLSTNLGEECLGQHLGAYQLANLGDGKGDVPQVQELRWNFGNPYVGTCQETLDGGLHLRYWIQNNTGAYFLASSIEKPASEYHDIPPDGYNIGRDEIVGNLTGTYIPPRTVSSSSTFQGTTSYANYTYQTSVQYVSGLLQNSSSALRVSHHPPKRHLMLTTHAVGVNHNQTVAVNGYPAIDGLVAVLTVKVTSSPKATTTGRAPLSKESSVGFLGSALAIVLLSVFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH88</accession>
    <name>A0A1Y1UH88_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_447112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871430.1">
        <property type="nucleotide sequence ID" value="XM_022012803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH88"/>
    <dbReference type="GeneID" id="33554611"/>
    <dbReference type="InParanoid" id="A0A1Y1UH88"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="195" mass="22222" checksum="DB3EC89CCCAC1D5D" modified="2017-08-30" version="1">MAFRAMLSHESTLEPDYRARLTLSLQASNVISTNLDRAQPHELFPRIGGRYQACVRLSKLGLSVAWQPHLNYEHQHHPNMSSVWTPQSRIVQLFAENQSKSQGKRSQNSFEHGAVSTTTGTGLPKGFSKHYLRGELPEMFYAVRRSRQAYHTLSLWRYAWTTRLTLFLTGRLTSTSISSKTATAPPLNPIRVKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHB8</accession>
    <name>A0A1Y1UHB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_627555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870955.1">
        <property type="nucleotide sequence ID" value="XM_022016011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHB8"/>
    <dbReference type="FunCoup" id="A0A1Y1UHB8">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHB8"/>
    <dbReference type="GeneID" id="33557820"/>
    <dbReference type="InParanoid" id="A0A1Y1UHB8"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="243" mass="26380" checksum="7C5FE5C29AFFE0F2" modified="2017-08-30" version="1">MSMVNIRQIELVSNPAKFDDEYHFRIKFEAIAPLQEDLEWRLIYVGSAKSEEYDQELDSCLVGPIPAGINAFDFLAPAPAHHLLPSVEPEEILGVTVIIITASYRDKEFVRVGYYVNTYYEDEAMMETPPATVEWDKLYRNVLIARPKVTRFQNPWDTGAASPFDAPLQQEAGQSSSGGGSNYMLDSAPLPPPVTKAAPALPSAEESDMSGGNGSDHNNGFGSGISNGHASGHGGGMDVEMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHL5</accession>
    <name>A0A1Y1UHL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Voltage-dependent anion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_651437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871033.1">
        <property type="nucleotide sequence ID" value="XM_022018337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHL5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHL5"/>
    <dbReference type="GeneID" id="33560146"/>
    <dbReference type="InParanoid" id="A0A1Y1UHL5"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="409" mass="45723" checksum="A36385BFF3243023" modified="2017-08-30" version="1">MRSLHVRTWSWQMFNVNLGTGGFAIVLASIPHKFRGQHAIGTVFFIIDIVVFIVNVVMLSLRAIHFPHLFALSFKSHSEGVWTPVSAVALSTLLTNTMLYGIPYCGPWLLIVCEVWYWVYMFLALCLTLAYKRNFRTISRKLSEISPPDALEVYPLMFCGVVGATLATKLAERYARRAFTVAIFSYVVSGTPRPFGNVLIASGLGFFNGLLILSVYVAHDLMIKNTSSSVLPSHLISVGVPGFTAYTTINLGHAALTLWRENDIFAGAGEGGPDPQLAGQIFFCISIWFCLLLVGMGAWLLMGFSWNAFWSWTTNPRRPIFRRWHYTWWGWTFPLTGFVGSLGRLGSYLPSRAFSILNIILVCFMGLMWLFNIVGTIVIIWKGELPGGEETIEMTRRQSDSDDEGGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHL8</accession>
    <name>A0A1Y1UHL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_622344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871535.1">
        <property type="nucleotide sequence ID" value="XM_022015466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHL8"/>
    <dbReference type="GeneID" id="33557275"/>
    <dbReference type="InParanoid" id="A0A1Y1UHL8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="155" mass="17142" checksum="451A297F4B1D4A8C" modified="2017-08-30" version="1" fragment="single">MITNRSEMETQYSQHVRQGVPEGTARLACRTRFQYCGNRTDPHHLPTCPTWSECLTFCNAHKCEDQCRVSIAIAEHSADWTDEDPQLSDWDVIGSLHQGSVENDTNTTAAEAAEAGRIEEAADKILNMSLGNLALECRPLGPADVHSDLATEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHR9</accession>
    <name>A0A1Y1UHR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_387960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871600.1">
        <property type="nucleotide sequence ID" value="XM_022012653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHR9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHR9"/>
    <dbReference type="GeneID" id="33554461"/>
    <dbReference type="InParanoid" id="A0A1Y1UHR9"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="264" mass="28818" checksum="75D95D5826A8B127" modified="2017-08-30" version="1">MSRPTMSALRSLSLLRSSSTTTTLPLSSRSFSTACARLMASSPQSGPGSLRPPPAKGASSGGNMLDASSPQSRHANETMPGSAPAANPGGTAEDGVVDYSTGQSAIDKAAHLFFLTEMARGAWICMEQFFRQPYTIMYPFEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAITIESEAREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVETQNAEFSTETREELLYNKEKLLSNGDRAEAEIAANLQADHFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHS6</accession>
    <name>A0A1Y1UHS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FRG1-like family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_589334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871559.1">
        <property type="nucleotide sequence ID" value="XM_022013776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHS6"/>
    <dbReference type="FunCoup" id="A0A1Y1UHS6">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHS6"/>
    <dbReference type="GeneID" id="33555584"/>
    <dbReference type="InParanoid" id="A0A1Y1UHS6"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33098" checksum="85411F4144700B91" modified="2017-08-30" version="1">MSSSGVVSKKLKFKGDKPKKKKRHHREVEDEDGDVEFQAMASADPKGWIFPSEPVEVSGPAFILLPTEPLTCLAYDPQRQRVIAAPVEIPEAPEGMDDLSPSEVLAVVEPSDINHVWVASRLSGSEEVISLRTTAGTFLTASPSGVLTAVVASRGPLEAFKPMPVSSSSPFPSFSLWTSSEKYISVTPGPSLGGKIELRADSESVGERESFRIKCQREFVLKAKMGTEGEKGKRRMGTIGGGGGAAAVGGSVEDEIKRNKQAQTWGAGRVVVSDQDRSELKRAKKEGRLAEAMLDRRAALKSDRYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHU8</accession>
    <name>A0A1Y1UHU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871104.1">
        <property type="nucleotide sequence ID" value="XM_022018188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHU8"/>
    <dbReference type="GeneID" id="33559997"/>
    <dbReference type="InParanoid" id="A0A1Y1UHU8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="709" mass="79025" checksum="DD300C3E615E90EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIA9</accession>
    <name>A0A1Y1UIA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation protein SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_641895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871787.1">
        <property type="nucleotide sequence ID" value="XM_022017457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIA9"/>
    <dbReference type="FunCoup" id="A0A1Y1UIA9">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIA9"/>
    <dbReference type="GeneID" id="33559266"/>
    <dbReference type="InParanoid" id="A0A1Y1UIA9"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="6">
        <location>
            <begin position="54"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="5">
        <location>
            <begin position="252"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="425" mass="46435" checksum="0EAD963A7D714D3F" modified="2017-08-30" version="1">MLDRRKDESILKVWKGKGVPHVNSVRNRISLIHPHLWRGKPFRELTHAKRKTGGRDETGRIATRHVGGGAKQRIRTIDFYRFIPGIHDVIRLEYDPGRSSHIALLKRRDNDAKPLTPNETTEERKVAWQVMHGEGKGRGKFPSEAKKAVLSGWSYITAPDGLRAGDTVRSFRMGVPQDYVEGWNDLRNSGAIRRAADKAMEAAEAGVDEDLNDEYDIDDDPASPQTVNPPAVSHADAEIGPRALALFRTEAMQPGNVLPLYLIPPGTPIHNIALNPLAKMTLVRSAGTTAELVGHTDLNGDSLGGLDVLKIGGQMRWDGSVTKTNGWALVKMASGEIRRISPGACATVGRVSNHQHNQISLGKAGRARNLGRRPRNRGVSMNAVDHPMGGGKGKGKSGKESTSIYGWTSKGRRTRRASDKGGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIM2</accession>
    <name>A0A1Y1UIM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative mating factor receptor-coupled G protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_642210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871384.1">
        <property type="nucleotide sequence ID" value="XM_022017472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIM2"/>
    <dbReference type="FunCoup" id="A0A1Y1UIM2">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIM2"/>
    <dbReference type="GeneID" id="33559281"/>
    <dbReference type="InParanoid" id="A0A1Y1UIM2"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="39102" checksum="3F9285A6ADAEAA33" modified="2017-08-30" version="1">MATVSQADIQERISAARREADGLKDRIRAAKDQTGDTSLRAMANDTPPIPRITMKPRRTLKGHLAKIYALHWAADKRHIVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLRGAGPGAPPGQAKVARELSAHSGYLSCCRFLNDRQIITSSGDMTCMLWDIEQGVRTMEFNDHTGDVMSISLAPNANLFVSGACDSTAKVWDIRTGKAVQTFTGHESDINAVQFFPNGDAFATGSDDATCKLFDLRADRELITYGYQDITCGITSVAFSLSGRLLFAGYDDYNCNVWDTLKGERVGVLAGHDNRVSCLGVSGDGIALCTGSWDSLLKVNTSSATTGSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJK4</accession>
    <name>A0A1Y1UJK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_339749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872084.1">
        <property type="nucleotide sequence ID" value="XM_022012522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJK4"/>
    <dbReference type="GeneID" id="33554330"/>
    <dbReference type="InParanoid" id="A0A1Y1UJK4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012327354" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8016" checksum="C64228C039EBA669" modified="2017-08-30" version="1">MDWRHSQNIRLCSRLALVLPCLTSAASAVTRISSANPFLKLLLSMPTCNEACMAQPARLLDGGALGLRQTLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJP7</accession>
    <name>A0A1Y1UJP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872212.1">
        <property type="nucleotide sequence ID" value="XM_022015266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJP7"/>
    <dbReference type="GeneID" id="33557074"/>
    <dbReference type="InParanoid" id="A0A1Y1UJP7"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14278">
        <property type="entry name" value="UBA_NAC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="1">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="129" mass="13675" checksum="57A781839F0E30DB" modified="2017-08-30" version="1">MAASSSTGRVPQGEVIIDFADGGSFIKNKLDDAVLTLERRRLEREEQGKAQKAMEALKVGSGEGTVGSTAGEPKSSDVDFVVAQVGCSRAEAETALREEKDMVKALIRLVKPRQRARSVDGGAEPSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJS0</accession>
    <name>A0A1Y1UJS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RIC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_578084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872154.1">
        <property type="nucleotide sequence ID" value="XM_022013302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJS0"/>
    <dbReference type="FunCoup" id="A0A1Y1UJS0">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJS0"/>
    <dbReference type="GeneID" id="33555110"/>
    <dbReference type="InParanoid" id="A0A1Y1UJS0"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="805"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111090" checksum="A8D35AE63CFCFD1E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJU8</accession>
    <name>A0A1Y1UJU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872181.1">
        <property type="nucleotide sequence ID" value="XM_022018026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJU8"/>
    <dbReference type="GeneID" id="33559835"/>
    <dbReference type="InParanoid" id="A0A1Y1UJU8"/>
    <dbReference type="OrthoDB" id="2595795at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="293" mass="30913" checksum="CF8F217F5A1FA954" modified="2017-08-30" version="1">MPKTMATSVAVHPPTVHPTRDHGLARPTSKHVNLSPPHHHGRSASTASPPAIERRSESLMALTTTATRRPPPAALPHPDKPSDPSIPFCTHWRDYYPGPPLDPETILPKPTSKQRFYSTKWKLDNPNPKTREGAKAFYGSGMGMGYPGMMGGMGGMGGMGMGGMGGMGMGMGYPGMMGMMSGMGMMPGMMGGMGYGMPRYMPGGMYGGMGGYGGYGGMYDPMMGYGTPPAALFVDDNPDAHRIEHAYRQSMPDSYGVGLGMMGGMGGGMGVNAMPGSQMLLYGRGMGYGGWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKF3</accession>
    <name>A0A1Y1UKF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_578025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872453.1">
        <property type="nucleotide sequence ID" value="XM_022013294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKF3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKF3"/>
    <dbReference type="GeneID" id="33555102"/>
    <dbReference type="InParanoid" id="A0A1Y1UKF3"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="2"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="494" mass="53405" checksum="72C8C63804BFDB6A" modified="2017-08-30" version="1">MPPFPFPLPTTSLISYANLLHDTSLSFTAELAEATSARTTLQLALKALDENNPSASALSVVDAVQGYLPYLQSIIHSLDSDLLLPKSELSFTWTPSLTSYPLKTPALTLPSIHAEHLFVLLVYALSLSNYANSILRSLPVFESIQDSKGKSKAGGAAQSVVGRLTAEDEKKITVGLGRAVDLLCQASGIATYVADKICPVFEGAKKGAGRNGKLKWPVETGAEAFRGLAMVFLADAHVTAIRKLLLPVLTHSLFSPPGPPLPSNHPSPSLLAKLYLHTASLYESARAFFKVRGGESSSNRKLFSRDKKTGDTEPHDTTEGDPIPELQRYLRKESLLASALARKWLGVDAGENSKEPQTGEALAWVKDAQSRLEELEDSAVREKMKGFSLSRGGDKKKEARKARKGRVERELEDVRAWIASYQALNDKVSFQPVPPSSSLVVPSGRQVFNAKTFVPPPNKFGSTFKVPLDGSTPDSEGAQNASPTEAYAGQGNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKW8</accession>
    <name>A0A1Y1UKW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ceramide synthase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_370533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872544.1">
        <property type="nucleotide sequence ID" value="XM_022012609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKW8"/>
    <dbReference type="FunCoup" id="A0A1Y1UKW8">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKW8"/>
    <dbReference type="GeneID" id="33554417"/>
    <dbReference type="InParanoid" id="A0A1Y1UKW8"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="196"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="412" mass="48396" checksum="D6F9DE7D8336D430" modified="2017-08-30" version="1">MATRPDNRRRSSSITQALRRVPLNQQGDKPLTPTNEEVKPLPAGKPRRKAGSSSFSYASKGFWNDIKTGRWMLVPASSFKILAAEFALWAAIEVMLTRLDTTSKTPFNPLSFIRSHPSGHHWNPFSYLNLDAQHTYPNPMSYFLFPQGLLPNGMARKSWADFVFVAQHIITWSFVRQFWCVLILPVIAKALRVKRSKIMRFTEQGYAIVYFGIMGTIGVYVMKGLPTYWYQTEHFWLEYPHKSMTYELKAYYLLQAAYWVQQLLLLVARIEKPRKDFKELVAHHIVTLWLIGWSYTIYLTHIGNAIYVTMDVSDIFLALAKCTNYVNETASIPVFAFFVLVWTYFRHYLNIKILWSVYSQFHLIPASERQVFDPLNDKWMPPWMKWQIFTPILLLQFINLFWYFLILRILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKX8</accession>
    <name>A0A1Y1UKX8_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872632.1">
        <property type="nucleotide sequence ID" value="XM_022015432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKX8"/>
    <dbReference type="GeneID" id="33557241"/>
    <dbReference type="InParanoid" id="A0A1Y1UKX8"/>
    <dbReference type="OrthoDB" id="2563880at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
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            <begin position="1015"/>
            <end position="1134"/>
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            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="850"/>
        </location>
    </feature>
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            <end position="937"/>
        </location>
    </feature>
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    </feature>
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            <end position="1075"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1091"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1148" mass="123111" checksum="A7317A9203597E76" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKY5</accession>
    <name>A0A1Y1UKY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_650057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018088.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UKY5"/>
    <dbReference type="GeneID" id="33559897"/>
    <dbReference type="InParanoid" id="A0A1Y1UKY5"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="489"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="622"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="669" mass="71652" checksum="142C79601A9380AA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULC7</accession>
    <name>A0A1Y1ULC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872713.1">
        <property type="nucleotide sequence ID" value="XM_022014935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULC7"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULC7"/>
    <dbReference type="GeneID" id="33556743"/>
    <dbReference type="InParanoid" id="A0A1Y1ULC7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36231" checksum="C0D0776C620B5439" modified="2017-08-30" version="1">MSYKAPPTGTYVPTLSFWKDRWNETPDLGTFRRHLERLSDDGVRGVTLFSYFGEGPYVSAVERGQFLEIASETLKPKGVIILVECSSESLQETSQKMADAKKGGADYAFLSVPMGYLDELDLEDIFEYFAEVSEWSDLPFVVRAPSGDVKISFSPEFIDRLASIPNCVGCLMPAFSPAIQGVAEKFAGGDDFAIFVTYPGDVGPKRLRIRLQGSIGNITPVTLVKFYDDPDGRVLETINAILTTKVLRDIATKVTALKYAMTRVRGYGGTCRPPLPVPHRELTARVDPILPSLAGDFAQRRWMALDGIDIHDESTGSGLRRAGTFTPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULH1</accession>
    <name>A0A1Y1ULH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_617828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872761.1">
        <property type="nucleotide sequence ID" value="XM_022014949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULH1"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULH1"/>
    <dbReference type="GeneID" id="33556757"/>
    <dbReference type="InParanoid" id="A0A1Y1ULH1"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="4">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="326" mass="35424" checksum="EACCEEC55266913A" modified="2017-08-30" version="1">MDAGPSKSSTQPEPVDSLISSESGSGLNISLHPLPILNISDHYTRARLTSPDHPEKLIGALLGTQSNRDVSISNSFELVYQMEHGAAGGDVDMSEGANRSPNKGSNLNIDFLTRRGDDFKEVFPTLDIVGWYTIGQTPTADHARLHRQFLEKVDSPLFLLFDPSQLGDGLPFSVYEASFADTSSSSTFTAAGTKFIKLDYAIETGEAERIAVDGISRGDAGAQGDESGVVGNLTTLRNAIGMLHERISILTAYITGVINKTAEPDQSILRQLSSLVSSLPTIDSVGFQEEFMTVRCDRHRLSYLIVDLISSCRNTAMFNWPNTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULY9</accession>
    <name>A0A1Y1ULY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_641634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872426.1">
        <property type="nucleotide sequence ID" value="XM_022017433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULY9"/>
    <dbReference type="GeneID" id="33559242"/>
    <dbReference type="InParanoid" id="A0A1Y1ULY9"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="289" mass="32712" checksum="F9C31D39556911E6" modified="2017-08-30" version="1">MAAAAYLGGPITALVLLILETQNDYVRFHAYQSALLTTPLLALILFFHLVISLPAFLQILLIIGSVGITLWTSFRAWKDAQEGLSRYWLPYIGEVAERWVSEEKNYLSLPLWPTLILTFLLGIGVGTLSSSHRQITHQQQQDGFTSSAFRIDKSQFLPAPPLPERPSYLPEPVQPKVSGMVVPNALHYVYGLKPVKEGEKVEELPYYAYLAIRSAIINLRPEMIFFHHQNVPTGPWWDEIVPHLTLIKTQVPDSYLGRKLSHFAHKADVLRLLAMKYSGGIYLDIDMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM57</accession>
    <name>A0A1Y1UM57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873001.1">
        <property type="nucleotide sequence ID" value="XM_022017957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM57"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM57"/>
    <dbReference type="GeneID" id="33559766"/>
    <dbReference type="InParanoid" id="A0A1Y1UM57"/>
    <dbReference type="OrthoDB" id="4641034at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="116" mass="13222" checksum="6453B40CD756C5A2" modified="2017-08-30" version="1">MPMEKPEWKEVGGPDSWNIPPGEFTVFGTVWVWPEHAEHVNILYSKITSVALADPGTVYYCISRDQDDPAVFHFFERYQDRASFDAHNEHPLVKELLASGWTKDIKAVFAKAVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMW0</accession>
    <name>A0A1Y1UMW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873253.1">
        <property type="nucleotide sequence ID" value="XM_022015180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMW0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMW0"/>
    <dbReference type="GeneID" id="33556988"/>
    <dbReference type="InParanoid" id="A0A1Y1UMW0"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="20686" checksum="6FB2DA91816943DC" modified="2017-08-30" version="1">MSGKDQYTASAGKSVSLSQKLDDLHAFIKKHKTVMLVTRSPSGSLHSRVMVPADITKDMKIRFIYDRDSYKDKEVENDSHVNVAINGMEGNDGWASISGKAGRVEEEGLIAKLYNPTLKAWFGDKGDGVHTGGPEDPRMAIIEVKPDEIRHYHQTRSSIGTAVDVVASAISGSTATPGEVRTITSDELASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMX7</accession>
    <name>A0A1Y1UMX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_617494</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872697.1">
        <property type="nucleotide sequence ID" value="XM_022014925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMX7"/>
    <dbReference type="FunCoup" id="A0A1Y1UMX7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMX7"/>
    <dbReference type="GeneID" id="33556733"/>
    <dbReference type="InParanoid" id="A0A1Y1UMX7"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX38834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="179" mass="19792" checksum="F4BB0A31E84ED146" modified="2017-08-30" version="1">MFSSEIARLRKLGVQGLLFQALNFLTVVASGLAMWKALCLVTNSESPIVVVLSGSMEPAFYRGDILFLTNPADTPYEIGDITVYKLPGGDIPIVHRVIESHITNTTQRLLTKGDNNTSDDLVLYSPGMEWVERKHVIGKVRGFLPYVGYVTIAMNDFPQLKYALLGSVGLFLLIQKDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN89</accession>
    <name>A0A1Y1UN89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872789.1">
        <property type="nucleotide sequence ID" value="XM_022017924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN89"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN89"/>
    <dbReference type="GeneID" id="33559733"/>
    <dbReference type="InParanoid" id="A0A1Y1UN89"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="314" mass="34408" checksum="74235F56DA8A1CE3" modified="2017-08-30" version="1">MAGPSEMSYRIFLSETPFRSPPRIHNQFYKDILVRNRNPPPTHAGQTSSEEYEKMISVGDTLLHAIVACTLHTAFPEMTVKTAQQYKVQLTSIDTLSRLSKKLTITRSGVFDDPTPPRDAANVLKAYVAAVYLGHLKDGTKRAGDAVNILEAWLSPVFVSLASNLEVQPQAVASTEEILCERSEGVPHGLEIQEAILEISDDTNTSPTSLDISKLHDLRNKNILDFTAKCEAQKVGTWQSVIRGRHRGVEFCPSIVRAQKKDAERAAAHLVLRKFGLNKHKALAKSLIGSGLKGGSKAKEKTPGQQTSETAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNG0</accession>
    <name>A0A1Y1UNG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_618158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872859.1">
        <property type="nucleotide sequence ID" value="XM_022014997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNG0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNG0"/>
    <dbReference type="GeneID" id="33556805"/>
    <dbReference type="InParanoid" id="A0A1Y1UNG0"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="55" mass="6132" checksum="05C180147894F584" modified="2017-08-30" version="1">MGIKVGINGFGRIGRIVMRNAIEHGDLDVVAINDPFIPLDYMVRRDRASVYAILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNV8</accession>
    <name>A0A1Y1UNV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative heterokaryon incompatibility protein HET-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_614753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873515.1">
        <property type="nucleotide sequence ID" value="XM_022014641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNV8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNV8"/>
    <dbReference type="GeneID" id="33556449"/>
    <dbReference type="InParanoid" id="A0A1Y1UNV8"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012621071" evidence="2">
        <location>
            <begin position="25"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="771" mass="83645" checksum="18520EAC98186B07" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP05</accession>
    <name>A0A1Y1UP05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_614850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873534.1">
        <property type="nucleotide sequence ID" value="XM_022014651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP05"/>
    <dbReference type="GeneID" id="33556459"/>
    <dbReference type="InParanoid" id="A0A1Y1UP05"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012372546" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="146" mass="15900" checksum="FD4455E5A16D05C7" modified="2017-08-30" version="1">MFTAALLMLAPLAAMASPIARTDATSQRIVLKSNTKQCVTAYGLAPQAGDILAIAPCEEPANQYYLHQFFLTEGIDSTAPVQLASTNLCIDAGSDAPSEYTSLTLQECNGSKQQSWYWFGASELEINSKFLARSCRESWLTRHSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP77</accession>
    <name>A0A1Y1UP77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_615231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873635.1">
        <property type="nucleotide sequence ID" value="XM_022014698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP77"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP77"/>
    <dbReference type="GeneID" id="33556506"/>
    <dbReference type="InParanoid" id="A0A1Y1UP77"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35562" checksum="43ECF49BAEE8AB83" modified="2017-08-30" version="1">MYPHLHVLLPSSSPGIALEARLYLSDVISSPAAAVEIEYCPVPFSASARSRPVDVGHPSNEQSTKLNAWLKSRAVQRLIVACHPWGKLGGSCLDPVISQHLVTSISGQHIDDSGLEAGASLTRISLARGMPNLQTALLTWNVRGVGVSQGSLGLLGLSNRTNERDLEALEDWAFEQFSVLKDYRRMGYSWGSWTVVTPPRSSAIGLLSSVLLVSPPLSIFTLLALPFVPIPNQSFSKSLEALMTSSNSGPDSRRHANTWLAYGANDEFTSRETYAKWGEDHRAMLSTGALVMRELEDAGHFYRHTHEGQWLLRVFVDWLAGDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP90</accession>
    <name>A0A1Y1UP90_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873636.1">
        <property type="nucleotide sequence ID" value="XM_022017845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP90"/>
    <dbReference type="GeneID" id="33559654"/>
    <dbReference type="InParanoid" id="A0A1Y1UP90"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="204" mass="22545" checksum="AD2CFBF039650033" modified="2017-08-30" version="1">MANLRDRITIRAFCDPYEPTISLPTPSMNPYAGSYDSSITSSLDSPSWAPCSPVIASPTWQPSSPSPPDQRLYEHTSAVYAPSGQMWPANNDYSYVGPEDQSAMLQRPITPAKRVRSTPESSPAWVRSTYRERNQSPCPTRATQDASLVYGNADLTEKSKKTAAPPLAKSFSGYQLANRLKPARKGERRTIRASRPTVFDDQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPB7</accession>
    <name>A0A1Y1UPB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rec8 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_649472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873260.1">
        <property type="nucleotide sequence ID" value="XM_022017994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPB7"/>
    <dbReference type="FunCoup" id="A0A1Y1UPB7">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPB7"/>
    <dbReference type="GeneID" id="33559803"/>
    <dbReference type="InParanoid" id="A0A1Y1UPB7"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF51">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN REC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="614"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="664" mass="73327" checksum="8A13B8E21F9E975D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQE4</accession>
    <name>A0A1Y1UQE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_617195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874075.1">
        <property type="nucleotide sequence ID" value="XM_022014895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQE4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQE4"/>
    <dbReference type="GeneID" id="33556703"/>
    <dbReference type="InParanoid" id="A0A1Y1UQE4"/>
    <dbReference type="OrthoDB" id="2594973at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="128" mass="13955" checksum="3966FB14CFBD0CA0" modified="2017-08-30" version="1">MRCVGPRTTADAISCGHSTLEKMGDGATRTVEPIEVLCRNLLTVVRRGGKWICVSYSTTRFQHLHRGGSAGDMSISGTSDPPRQGWKVIAKRSLRETSGQRTIKDGSGERIVYEPSTSVSAYILEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQG5</accession>
    <name>A0A1Y1UQG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_678900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873592.1">
        <property type="nucleotide sequence ID" value="XM_022019018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQG5"/>
    <dbReference type="GeneID" id="33560827"/>
    <dbReference type="InParanoid" id="A0A1Y1UQG5"/>
    <dbReference type="OrthoDB" id="2576470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="213" mass="23216" checksum="FC4F40F9EB2FFC5B" modified="2017-08-30" version="1">MPKTTHHNKPGSRKSGSATKPTFTKVTKAAREGAPAPAPNESTQEPTPEIPKDLFLQIIVAKLNTSKTCDWFELSKVVILPGLKSGKVVWAESETSLTPTNLRETPTCISDHAETKPPFKSQIAKRRASTLSVDDAIAPMKKTRKTTKAMVGLPDIPDTPDSICARFKRSSRKSISYREDLLTDDEFSGIEDDEEDPDGASGTGDSMDESVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQJ7</accession>
    <name>A0A1Y1UQJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_617122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874054.1">
        <property type="nucleotide sequence ID" value="XM_022014884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQJ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQJ7"/>
    <dbReference type="GeneID" id="33556692"/>
    <dbReference type="InParanoid" id="A0A1Y1UQJ7"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="97375" checksum="41DCCE716C21C163" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQV4</accession>
    <name>A0A1Y1UQV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inhibitor of apoptosis-promoting Bax1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_610848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874147.1">
        <property type="nucleotide sequence ID" value="XM_022014224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQV4"/>
    <dbReference type="FunCoup" id="A0A1Y1UQV4">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQV4"/>
    <dbReference type="GeneID" id="33556032"/>
    <dbReference type="InParanoid" id="A0A1Y1UQV4"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="290" mass="31948" checksum="1AF0FB085745177C" modified="2017-08-30" version="1">MALPPKYTDDPAPEAPTIKTYGATPNTSQANEPLLAQSASAPRAGGMPGSSTGNTWMDQPSEDDIPDDFKVGVAVIDCDAAIRLAFIRKVYSILFIQLLATAGVSVVLSLPQATSFMQQHGWIIWIPVLGSFASLMGVYWKRHQHPANLILLGLFTMFEAMMVGTVVSYYESRIVLQALFITMGIFIGLTLFTFQTKWDFSSLGPFLFAGIMGLLTMSLVQIFLPFNANVDLAIAGFSVMLFSGFVLYDTQMIMKRLSPDEHIVGALQLYLDFINLFLAVLRVLNNQNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQY8</accession>
    <name>A0A1Y1UQY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_1395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874140.1">
        <property type="nucleotide sequence ID" value="XM_022012008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQY8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQY8"/>
    <dbReference type="GeneID" id="33553816"/>
    <dbReference type="InParanoid" id="A0A1Y1UQY8"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="358" mass="39392" checksum="123D0D162E8E3AC0" modified="2017-08-30" version="1">MQDESSQVQVIHEGRHASIVLWKRSPGQSIIVKAFQQDSIPLEILVIRKLPRHRNIIYEIKDVFTQDFGISIALPCLPVSLNDVLTSPLDGRPAVPQVMAHQLCAGLAFLHTRRVAHRDIKPDNVMLDSDGTVVIIDFGSVWTDNEMFRGTSPPDRMDYQVGTGPYRAPELLFGPTIYDPFAVDSWALGCVIGEMLLASDSGRAPGTLFDAAFGDLGLAGSIFRLTGTPTEQTWPDFGSLPDAGKFAFDYREAVPLHRRIHAQPEAIDLVSKLLQLDPSTRLSPAQALVQPWCSLLASPPNLSRSRPDDAFIGAARLGHSPIQDRAMQPDAAEGHTDDQIVRDMSLDRHSDASHTPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR93</accession>
    <name>A0A1Y1UR93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_7587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874239.1">
        <property type="nucleotide sequence ID" value="XM_022019241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR93"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR93"/>
    <dbReference type="GeneID" id="33561050"/>
    <dbReference type="InParanoid" id="A0A1Y1UR93"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="265" mass="29098" checksum="00E9384B3892A118" modified="2017-08-30" version="1">MVQKQPRRARGHRDSRVSSESESDSDGQLTPEASPSPPSTPGNNDGSARHPGLVSPITDSDSDAHPVASREHPRRSQAPTPESEDNSSDDNRPTPPSTRSTSKAPTLRKTIISSGEEEEDNEPPPRPSRKSSATSQRAKSAAPSRYKAGTANRRPPRPTKTSGEGAEFDSGDETVESQRKRYEERQQRQPSSIGSPWRALKRSWRWFWGWEGWILVRAYIAIPIALTISCLMLAIGATGPAPGITWWWFCISNDIKLGGIGYCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URF0</accession>
    <name>A0A1Y1URF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_611184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874218.1">
        <property type="nucleotide sequence ID" value="XM_022014247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URF0"/>
    <dbReference type="FunCoup" id="A0A1Y1URF0">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URF0"/>
    <dbReference type="GeneID" id="33556055"/>
    <dbReference type="InParanoid" id="A0A1Y1URF0"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="161" mass="17841" checksum="B95643CA1ED2C498" modified="2017-08-30" version="1">MSDSLHRSIIDTMRVLPKNKLFAKTQTIPGYGHFLTPLRKLILDYSDWSPVHDGLRSYLKGPFVKVAQANPDVEFVVRMVHRNGNGLLRGHYVNGRDKVICVNKLTQSEVAKKVDILLNASGLQIRSMKNLQLQHAPGAESARGIWSSLHAAKGSAGAFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URI4</accession>
    <name>A0A1Y1URI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_616235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873879.1">
        <property type="nucleotide sequence ID" value="XM_022014809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URI4"/>
    <dbReference type="STRING" id="4999.A0A1Y1URI4"/>
    <dbReference type="GeneID" id="33556617"/>
    <dbReference type="InParanoid" id="A0A1Y1URI4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52988" checksum="E643D51140BCDE26" modified="2017-08-30" version="1">MGQTKPEYLQPYTSAAPSHYLRHKNGWPHFITFVLSFSSDDAPSMPFLRKRLEDMQVRYPDTRLSLVERPRPESHTLYWSPVSWHQQDDAWPINHILQELDSAPASSLDAYRIAIHLAEQRSLVDCPLFVVHRLVGPRQTFICLSVSHTLTDGIGASNMLRAIIEPELEQFSDESQKGFFNGNLGKPPQVAPLKPYEPFKPDIKGENRDDLAKKDAPIWPASADDFKIHPSSDLPSQFVDVHFSADTIKSLSTKAKSVQIATLNTVFLSTFVMAVIEVMGIKDRRLQSVVPVSFRKKAENPLFFGSFTTALDIITHCTPKTSTWSFIREFSVPANKQVAEAIEARQKPKVDDDRKTKSPVFDAESAMQRDLDRLKSDAAYMDSIVWSNLARLSWLDNVHGCNDVLWGQSTAMFFAPICMSVVGWKGGMRSVCGFKEGSGFTSEQVATIIARWEEIVQEAVDADVKGDVLDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US47</accession>
    <name>A0A1Y1US47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_612097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874461.1">
        <property type="nucleotide sequence ID" value="XM_022014349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US47"/>
    <dbReference type="GeneID" id="33556157"/>
    <dbReference type="InParanoid" id="A0A1Y1US47"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="640" mass="72329" checksum="1835FFE8E656A4C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI1</accession>
    <name>A0A1Y1USI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_616615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873940.1">
        <property type="nucleotide sequence ID" value="XM_022014840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI1"/>
    <dbReference type="STRING" id="4999.A0A1Y1USI1"/>
    <dbReference type="GeneID" id="33556648"/>
    <dbReference type="InParanoid" id="A0A1Y1USI1"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="298" mass="32826" checksum="9ADE115588065127" modified="2017-08-30" version="1">MAMASTATMADSGPSRAAQSEPWIQDDTTPLFVAAAVTVLTATGAAAGASIGMFNERNPFSASATMGGRWFMASSTFYGLREYIISPFLTRYEVSSTHAILNQQISAKRQGKLPDLNDPTLELTRWQTRTQRVLDSGLTGGLVGGGAVWIIGGPRRAVRGGFSGMVAGSILQFSANSLRMLKRDIFDPPKPRLTPNTIPLSPSNLPVDTQMPSTPVNPSEQPNQSLWKRFTHATVKTLKAWSPIKKRTNEEMLVMYQAKRKALDERLIEIEAEELELYERIQEWQRQAESSGSTRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USX0</accession>
    <name>A0A1Y1USX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_640543</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874303.1">
        <property type="nucleotide sequence ID" value="XM_022017354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USX0"/>
    <dbReference type="FunCoup" id="A0A1Y1USX0">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USX0"/>
    <dbReference type="GeneID" id="33559163"/>
    <dbReference type="InParanoid" id="A0A1Y1USX0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="147"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="151"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="533" mass="60545" checksum="EE64B9AF0087CDFD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTF6</accession>
    <name>A0A1Y1UTF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BRCA1-associated protein 2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_647405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874154.1">
        <property type="nucleotide sequence ID" value="XM_022017651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTF6"/>
    <dbReference type="FunCoup" id="A0A1Y1UTF6">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTF6"/>
    <dbReference type="GeneID" id="33559460"/>
    <dbReference type="InParanoid" id="A0A1Y1UTF6"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="329"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="503"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="68617" checksum="09612CE3E7EEF473" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTI2</accession>
    <name>A0A1Y1UTI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_606552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874415.1">
        <property type="nucleotide sequence ID" value="XM_022014021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTI2"/>
    <dbReference type="GeneID" id="33555829"/>
    <dbReference type="InParanoid" id="A0A1Y1UTI2"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299390" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="219"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="299" mass="30310" checksum="AFA433D799B2F8B3" modified="2017-08-30" version="1">MLASRFLTLVSLIAAPLALASPTSTETAELDERTFGGLFGGGGLLGGGGGGGGSGGGLGLDLNLDICLTLDLNLGGLLGGLVKRTGGGFGGFQPHTGYGNWGQHHPGGTCGDLSQINNCYKVGHACDEHCVCVPPPPAVCTDQCAILKCQAKGQATNTDCSCKQQCDCQDQFNCWQQGGKLSSNCQCVVPSKRWHRRDLPTTCAAGYSSCPVPGSAGSECLNTLISMESCGGCTSLGQGTDCSAIEGVDSVSCVAGSCAVSSCQPGYEVSSTGTTCIRSDDTAEILVGALKSAEQLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTM0</accession>
    <name>A0A1Y1UTM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874455.1">
        <property type="nucleotide sequence ID" value="XM_022018796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTM0"/>
    <dbReference type="GeneID" id="33560605"/>
    <dbReference type="InParanoid" id="A0A1Y1UTM0"/>
    <dbReference type="OrthoDB" id="2687798at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="332" mass="34238" checksum="09D5075AE2428C1A" modified="2017-08-30" version="1">MYRLAISRSIRAAESTARVVAIRSASTTQGHTTAKAQDPGHKDKDVQSASATQGMSNKAASQASTNGQSQPFDAARQGGVGGESKVAPEGKGSFADQVGGQKGASSGGHKGGHEKTGADTLVGKVLDAFGGQNPKRQFHTWSSARNKDIPGADPKGARKPVDDSVHGDQNPHLKHSEGGYSGSAQSGNASADPHLPSRTKSKPQHSSNPFGSTPGASQSRSLHSSPTTGVKGAEKYSGVHEPEPSKAGYDSPSEPLPTNLKSSYPTNDPSATPAPPNVTPSSKVKKSSTSADPAHETLSQAAKEGTLGDRNPQPHPDAGRKGNDKAWKDRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTY9</accession>
    <name>A0A1Y1UTY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-glucoside:hydrogen symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_659644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874766.1">
        <property type="nucleotide sequence ID" value="XM_022018888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTY9"/>
    <dbReference type="GeneID" id="33560697"/>
    <dbReference type="InParanoid" id="A0A1Y1UTY9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX41087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="544" mass="60459" checksum="F245EE31817F3F2F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUG3</accession>
    <name>A0A1Y1UUG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_613659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874893.1">
        <property type="nucleotide sequence ID" value="XM_022014524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUG3"/>
    <dbReference type="FunCoup" id="A0A1Y1UUG3">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUG3"/>
    <dbReference type="GeneID" id="33556332"/>
    <dbReference type="InParanoid" id="A0A1Y1UUG3"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="689"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX41214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="750" mass="83748" checksum="B9D259B7BE634F1A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5K9</accession>
    <name>A0A1Y1U5K9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_654261</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000027">
        <property type="protein sequence ID" value="ORX33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867664.1">
        <property type="nucleotide sequence ID" value="XM_022018779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5K9"/>
    <dbReference type="GeneID" id="33560588"/>
    <dbReference type="InParanoid" id="A0A1Y1U5K9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055163">
        <property type="entry name" value="ALK/LTK-like_GRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12810">
        <property type="entry name" value="ALK_LTK_GRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="ALK/LTK-like glycine-rich" evidence="16">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="116" mass="12352" checksum="143712B34D9E69EF" modified="2017-08-30" version="1">MPVQPKPLSLQRQLPAPGTYYISAYGASGGPGQVQALPRYKEPRHGGLGAMINGIFYSKKGYGLTVAVGQHGGSFTSGSFANHLSYSPEPNDYKHGYYGSSRLTMIPTGGLDKGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U629</accession>
    <name>A0A1Y1U629_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_684197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867817.1">
        <property type="nucleotide sequence ID" value="XM_022019209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U629"/>
    <dbReference type="GeneID" id="33561018"/>
    <dbReference type="InParanoid" id="A0A1Y1U629"/>
    <dbReference type="OrthoDB" id="2562239at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="328" mass="36493" checksum="FF39FE4C7D1A76D8" modified="2017-08-30" version="1">MSFQQGSLDIILEPGENTLEDINFTGGFPTSRDLAPSILFIVLYALTLPVLIWRIVSPQYRSLLLLRPAMFFTCRMTSLIIRAIMSKVSSYSLGLLVAELVLISVGYLFLIEPVIIAWKRLISAQYHSSSSRHPPTWLNAVKNGLLVALISTIVIFVVSGIVSSQSPAHPNLLQVVRILREISYILSLGISSLLLVLVIVTGKVFKLPVIRTAFLVSLAAGMVTTGAYRVAQTYSVNPDSPARSLAAFWVLQISVEYVIYTLFLTISLPKWFPAGKEEVDTAGVCNNDLEIGLVNHRATVSQEVKLRKRPWYLKGPVTRFLVRDRYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U668</accession>
    <name>A0A1Y1U668_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_639655</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867850.1">
        <property type="nucleotide sequence ID" value="XM_022017261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U668"/>
    <dbReference type="FunCoup" id="A0A1Y1U668">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U668"/>
    <dbReference type="GeneID" id="33559070"/>
    <dbReference type="InParanoid" id="A0A1Y1U668"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="37"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="679" mass="75822" checksum="F72A1CCA08BCF442" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6B5</accession>
    <name>A0A1Y1U6B5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative mitochondrial aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_595551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867877.1">
        <property type="nucleotide sequence ID" value="XM_022013849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6B5"/>
    <dbReference type="FunCoup" id="A0A1Y1U6B5">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6B5"/>
    <dbReference type="GeneID" id="33555657"/>
    <dbReference type="InParanoid" id="A0A1Y1U6B5"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="216"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="717" mass="80688" checksum="5AFA6A1D38E68A7B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7C5</accession>
    <name>A0A1Y1U7C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_637731</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868217.1">
        <property type="nucleotide sequence ID" value="XM_022017039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7C5"/>
    <dbReference type="FunCoup" id="A0A1Y1U7C5">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7C5"/>
    <dbReference type="GeneID" id="33558848"/>
    <dbReference type="InParanoid" id="A0A1Y1U7C5"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="179" mass="20400" checksum="9866D177E76833BE" modified="2017-08-30" version="1">MIKIWSVKKNEEAAAKKKPKMTAAQLRVQKDLTELELPDTMKTHFPDPADVLNFTLTITPDEGIYKGGQFNFTFAINPNYPHEPPKVRCTQKIYHPNLDLEGNVCLNILREDWKPVLNLSSVMVGLQYLFLEPNPDDPLNKEAAEDLRRNRQSFISNVNTSMRGGSVKGERFDSVLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7K0</accession>
    <name>A0A1Y1U7K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_653688</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868280.1">
        <property type="nucleotide sequence ID" value="XM_022018691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7K0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7K0"/>
    <dbReference type="GeneID" id="33560500"/>
    <dbReference type="InParanoid" id="A0A1Y1U7K0"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="598" mass="67281" checksum="B06ADB1FE80EE69C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7N2</accession>
    <name>A0A1Y1U7N2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_193885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868329.1">
        <property type="nucleotide sequence ID" value="XM_022012142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7N2"/>
    <dbReference type="GeneID" id="33553950"/>
    <dbReference type="InParanoid" id="A0A1Y1U7N2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="195" mass="20516" checksum="37E792949CF23B11" modified="2017-08-30" version="1">MSVTAPTSPITDRAAARISPLSPNRSLYEGDSSSFAYRRYSSSRLSDTRRSLGAEEENTSASNGGGPAGSSSASGTNHPVDSAAGARDPLARDGTHVAPRWQAGPGYGAVNWREGFGSSNERRIAEEEALDPNSVPGSPDIDELDDQDESASTSAAGAGPTGSTAGTDDRPKRRSRRNPVKKEMDEPPNKKRRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7R4</accession>
    <name>A0A1Y1U7R4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867866.1">
        <property type="nucleotide sequence ID" value="XM_022017209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7R4"/>
    <dbReference type="FunCoup" id="A0A1Y1U7R4">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7R4"/>
    <dbReference type="GeneID" id="33559018"/>
    <dbReference type="InParanoid" id="A0A1Y1U7R4"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="302" mass="32702" checksum="F073BD703461E949" modified="2017-08-30" version="1">MSIQKLLVVGGNGFLGSAICKAAVGRGWEVSSMSSSGKPYATPAGHAPKWVDAVQWHAANAFEPSSYSSLVDSSTAVVHTLGILLEDAGYKKAVRDGNVFGVLGAIAKGVTGGQSSNPLKTGTERRLGYEGMNRDSALHVLDTMMASSSKNKSRPFVYISAADAFRPIVPERYVETKREAEREIFRRCQEDPARGIRPVFIRPGLMYHPHVRPISTLPAFLLSVSASLPLPNIFASRSLLGSSVTSLKTHPIHVDHVAEAILRSIDDPERVGVVDVELMRSWAGFQDAEEAVRRRSGLESIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7R8</accession>
    <name>A0A1Y1U7R8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_653744</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868341.1">
        <property type="nucleotide sequence ID" value="XM_022018698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7R8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7R8"/>
    <dbReference type="GeneID" id="33560507"/>
    <dbReference type="InParanoid" id="A0A1Y1U7R8"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="665"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="805"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="973" mass="106024" checksum="BCB3CF4ED709B7AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U806</accession>
    <name>A0A1Y1U806_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_636836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868421.1">
        <property type="nucleotide sequence ID" value="XM_022016936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U806"/>
    <dbReference type="FunCoup" id="A0A1Y1U806">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U806"/>
    <dbReference type="GeneID" id="33558745"/>
    <dbReference type="InParanoid" id="A0A1Y1U806"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="394" mass="45258" checksum="6B92886B32C33BF9" modified="2017-08-30" version="1">MSRSQLPSQGESSRPRSSVGRHDDSIRRQKILVLGWRKAGKTSCIKTVFEHVPPSEVAYFDSTQKFEKIDYDTIIPLQIWDTPSNFELETLDVPLSSFSTIIYVMDIQADDSYHEAMLPFVRILLRAYLSNPAVKFAVFIHKAESLSEDYRGENYAEIQRALAEELEDFPYTSLQQYSSLNFSDPSVTNIIINSIQSEVRFDMTSVHDVSLREAWSRVLQGIMEMLPSVESLLINFTGSSGMDNTYLFDMESRVVVASDNRGRNDATMQLVTEYLDKFLQFADLYKCLGKRKDDGEDLENGDMSNGRDNGVPDDDEEEDEPGSWWDQEDPDAPWMTQSTKLMPNTTIALWQFTPHLVLVILVRTDTWQTRRGMIEYNLTFLRQGVRRILMEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U859</accession>
    <name>A0A1Y1U859_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_654001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868016.1">
        <property type="nucleotide sequence ID" value="XM_022018736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U859"/>
    <dbReference type="FunCoup" id="A0A1Y1U859">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U859"/>
    <dbReference type="GeneID" id="33560545"/>
    <dbReference type="InParanoid" id="A0A1Y1U859"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7722" checksum="3AC7953AD120D745" modified="2017-08-30" version="1">MPFTCGDIVKIIFAVIFPPLGVFLERGCGADLLINILLTILGFIPGKSTRTILRARTLTIPQESSTPCTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8H2</accession>
    <name>A0A1Y1U8H2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_639714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867750.1">
        <property type="nucleotide sequence ID" value="XM_022017272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8H2"/>
    <dbReference type="FunCoup" id="A0A1Y1U8H2">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8H2"/>
    <dbReference type="GeneID" id="33559081"/>
    <dbReference type="InParanoid" id="A0A1Y1U8H2"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="62034" checksum="AA9DB3AAB966C0AF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Q0</accession>
    <name>A0A1Y1U8Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_604588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868683.1">
        <property type="nucleotide sequence ID" value="XM_022013984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Q0"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Q0">
        <property type="interactions" value="710"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Q0"/>
    <dbReference type="GeneID" id="33555792"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Q0"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="13">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="326" mass="36268" checksum="6E7952ED4B4C232C" modified="2017-08-30" version="1">MAEDPSGWSLTESDPQVFTQLLKDLGVKGLQVDDLYSLDSDTLGPLRPIHALIFLFKYVGGDEGESSSGIEVDSGENGVWFANQVINNSCGTLAALNAVMNIPPQSSEHPSESIELGPELENLRDFGSAMGPLDLGHTLSSHPLIREVHNSFSKSSPFSMDPAAFPEREREDAYHFVAYLPVNGVLYELDGLRRNPIMHAAVEDDWLDQARETIEARIATYPAGSLMFNLLAVRSDPLPRLTRLLNDPTTATQEKMTMQDQLYQERTKNERGAVENTLRRNNLLPVVFELFKTLGQSGKMGPIIEEARAKGRTRRERAKQRGEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Q3</accession>
    <name>A0A1Y1U8Q3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_583274</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868666.1">
        <property type="nucleotide sequence ID" value="XM_022013612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Q3"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Q3">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Q3"/>
    <dbReference type="GeneID" id="33555420"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Q3"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="15">
        <location>
            <begin position="95"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="16">
        <location>
            <begin position="265"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="342" mass="36027" checksum="2D91E9F9F7172C82" modified="2017-08-30" version="1">MSTQHSSSGSISVPFSATTGPSAQGQKSRFGVDSTMSLLVDSLKDRLLMAVPKKGRLHEKCLELLSGADIKYNRAHRLDVALVQNLPIALVFLPASDIPRFVALGSVALGITGQDVIAESTHAEDITQLLPLGFGKCALQVQVPVSGPIQSVEGLSGGRIATSFEVLAGAFFKDVDAKLGGQQTTKVEYVGGSVEAACALGMADGIVDLVESGDTMRAAGLHAIHTLITSEAVLITQRVPHESITPALAPIIPLIKSRFAGVLAAKKFVYASYNIQRAKLDAALSITPGRRAPTVSPLDEEGWVAVSAMVERKKMAEVMDELETVGAEDVLIFALDNCRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Y4</accession>
    <name>A0A1Y1U8Y4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868746.1">
        <property type="nucleotide sequence ID" value="XM_022016868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Y4"/>
    <dbReference type="GeneID" id="33558677"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Y4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="436" mass="47010" checksum="143F7914D63B5563" modified="2017-08-30" version="1">MLPGSETSASAAVSAAQSSHSPFNMPSPLSDFDMSPVPSPRVRSRAGVHTRSHSWCAPSPESPNDPTSSNARHPTSLSSEMTCKEFSETFKATETPVQRVSKRRPTTRGKKRGVDGSTHSSPSRPSQSTRSRSRSYSKSISPKQSLDSVHRREPIGDTSISFDSDHLVTPAPQASEHRRRIAPLRSSRSSLFATGSTPHPISIPIYAYRDKAPSRDSSPVPAPRNDSSPLKKPRTSLGGEIINFHYSSDSDSENETPSPPLRTRARFNSLLGPSPLHKSFSSSMSPPSPSGSLPKSVSASILPIRATRTPSGTQSQLGLPFRSERSLSSPSLGLSTGNFSPNSDLLSPLRARTKILSEVEGLETELNKVFALVHGKGLGLGAGGRGRRIGSGLRQSKGVDDAEEVRVEDESPLPRRATNREPRTREDHMEVDTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9D3</accession>
    <name>A0A1Y1U9D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_636677</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868394.1">
        <property type="nucleotide sequence ID" value="XM_022016922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9D3"/>
    <dbReference type="FunCoup" id="A0A1Y1U9D3">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9D3"/>
    <dbReference type="GeneID" id="33558731"/>
    <dbReference type="InParanoid" id="A0A1Y1U9D3"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="25423" checksum="0B5ED957C8B02144" modified="2017-08-30" version="1">MSGSNAAPMAPISRETRPSIVGGDEPESPYPIQLRGSVTKGFGRGARELGIPTANLPDSSLPPLNDLHLTGIFYGFARVHSSPSTSKSVSGYMASAPERSQDEPSTTLSPETISSLPSRTAPYPPAADAEPPAAEPKTLSAEDSRVWPMVMSVGWNPYYKNEKITAEVHILHPFAHNFYGHDMSVLVTGYIRPELDYVSKEALIEDINTDARVALNSLARPAYAALASDPFLAPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9W3</accession>
    <name>A0A1Y1U9W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_653077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869062.1">
        <property type="nucleotide sequence ID" value="XM_022018603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9W3"/>
    <dbReference type="FunCoup" id="A0A1Y1U9W3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9W3"/>
    <dbReference type="GeneID" id="33560412"/>
    <dbReference type="InParanoid" id="A0A1Y1U9W3"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="174"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="780" mass="88819" checksum="56305D3AF16D333A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA10</accession>
    <name>A0A1Y1UA10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_635491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868610.1">
        <property type="nucleotide sequence ID" value="XM_022016814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA10"/>
    <dbReference type="FunCoup" id="A0A1Y1UA10">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA10"/>
    <dbReference type="GeneID" id="33558623"/>
    <dbReference type="InParanoid" id="A0A1Y1UA10"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="58"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="282"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="664"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="718" mass="79011" checksum="007CFE4C33F8FFE3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAS6</accession>
    <name>A0A1Y1UAS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_634028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869356.1">
        <property type="nucleotide sequence ID" value="XM_022016692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAS6"/>
    <dbReference type="FunCoup" id="A0A1Y1UAS6">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAS6"/>
    <dbReference type="GeneID" id="33558501"/>
    <dbReference type="InParanoid" id="A0A1Y1UAS6"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="14106" checksum="6DC31C2E6C7189EB" modified="2017-08-30" version="1">MPPKQSAAASGSQKLTPQEVPAAFQRYRTELQNLAQKIGELESELEEHALVLSTLQPLVKTAPTRSCYRLIGGVLVERTVTDVVPALETNYNGIKEVLESLVKNYKGKEEDFVKFQNDYGIQMPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAX6</accession>
    <name>A0A1Y1UAX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_634427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868909.1">
        <property type="nucleotide sequence ID" value="XM_022016726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAX6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAX6"/>
    <dbReference type="GeneID" id="33558535"/>
    <dbReference type="InParanoid" id="A0A1Y1UAX6"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="187" mass="19905" checksum="279FB1B1327DF770" modified="2017-08-30" version="1">MIQLLLDQRPNLEAKDTMGWTALMVASAAGRIEAVNELLEAGANVDAVNEKGQTSLHYAASKGNVQIGRALIAKGADINAKDRASQHPLHRAATTGSEAFLKILLNPPEGRPKTRLNGADRAGNTPLHLAMESGHGEAAAILIEAGADRERTNGDGQVPEEIDGVGGQEQKRVREYLVSRVGTRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBE5</accession>
    <name>A0A1Y1UBE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_635718</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868668.1">
        <property type="nucleotide sequence ID" value="XM_022016835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBE5"/>
    <dbReference type="FunCoup" id="A0A1Y1UBE5">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBE5"/>
    <dbReference type="GeneID" id="33558644"/>
    <dbReference type="InParanoid" id="A0A1Y1UBE5"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="15">
        <location>
            <begin position="47"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="14">
        <location>
            <begin position="392"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="85"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="511" mass="54095" checksum="1AB34E32EF5FC4AB" modified="2017-08-30" version="1">MFTRTPMSSNLLRPLTNPSSSHSLSRGLIRTVPLGSSRGLATANEPYDVAIIGGGPAGYVAAIKSAQLGLKTVCVEKRGSLGGTCLNVGCIPSKAMLNNSHIYHQTQHDLKKRGIDVGDVKLNLPAMLAAKESSVKTLTGGIETYLFKKYGVDYIKGAASFASPSKIDVSLTEGGDTQVEAKNVIIATGSEVTPFPGIEIDEKKIVSSTGALDLTEVPKKMVVIGGGIIGLELGSVWSRLGAEVTVVEYLGAVGAGMDGEVGKQFQKILAKQGLKFKLNTKVMGAEKDGDNIKLKVEAAKGGKEETLDCDVVLVAIGRRPVTQGLNLEAIGVELDKRGRIVIDDQFNTSAKGVKAVGDVTFGPMLAHKAEEEGIAAVEIIKHGHGHVNYDAIPSVVYTHPEVAWVGKNEEELKAAGVNYKIGKFPFAANSRAKTNQDADGFVKFIVEKDTDQVLGCHIIGPNAGEMIASATLAIEYRASAEDIARTCHAHPTLSEAFKEAALSSYDQPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBH0</accession>
    <name>A0A1Y1UBH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caspase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_663244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869078.1">
        <property type="nucleotide sequence ID" value="XM_022018904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBH0"/>
    <dbReference type="FunCoup" id="A0A1Y1UBH0">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="GeneID" id="33560713"/>
    <dbReference type="InParanoid" id="A0A1Y1UBH0"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="143"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="48275" checksum="EF1E042214922071" modified="2017-08-30" version="1">MSWSSFPGQSQHGQYSNNPPPPQWGQAPPPPNYGYNSLGQNQYYPPPPTQYNAPPPPHQGGGGWAPPTGAPPPQQYHQTAAGYRPPNESQQGQGAPFGPPPSEPGAPYTLRPPTQQQQYGPQFQNGGGGQSRPFFQYSQCTGRRKALCIGINYFGSSSQLAGCINDARNVQKFLIERYQYRPEDIVMLTDDAQNPRQIPTRANMIQAMQWLVAGAQPNDALFFHYSGHGGQTKDLDGDEDDGYDEVIYPVDFKQSGHIVDDDSDTNRHEIMVRPLPPGCRLTAIFDSCHSGSCLDLPYIYSTEGVIKEPNLLAEAGQGILGAGMSYLRGDLGGAISGVFSLGKQMMNQNSGARERTIQSKTSPADVVMWSGCKDSQTSADTQEAGRATGAMSYAFIAALTKYPQQSYVQLLNTIRDELRGRYDQKPQLSASHPMDTNVLFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBV0</accession>
    <name>A0A1Y1UBV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_652734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869230.1">
        <property type="nucleotide sequence ID" value="XM_022018542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBV0"/>
    <dbReference type="GeneID" id="33560351"/>
    <dbReference type="InParanoid" id="A0A1Y1UBV0"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="3">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="100" mass="10322" checksum="3589784A4B2C4D2F" modified="2017-08-30" version="1">MSSGAISQSSSAATTSSNETSPSMSTSDDHGQKQPEWKDCTACRLTGAATFTGIGSYAIYQGYDQGAFAKVRPRGAPRSAQFTVAIGIVMIGLGLGRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBZ1</accession>
    <name>A0A1Y1UBZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-induced GTP-binding protein Mx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_657487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869222.1">
        <property type="nucleotide sequence ID" value="XM_022018865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBZ1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBZ1"/>
    <dbReference type="GeneID" id="33560674"/>
    <dbReference type="InParanoid" id="A0A1Y1UBZ1"/>
    <dbReference type="OrthoDB" id="2583551at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="28"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="659"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="746" mass="84811" checksum="D5EBFC5D6BBB1452" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC85</accession>
    <name>A0A1Y1UC85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_582487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869322.1">
        <property type="nucleotide sequence ID" value="XM_022013561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC85"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC85"/>
    <dbReference type="GeneID" id="33555369"/>
    <dbReference type="InParanoid" id="A0A1Y1UC85"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="43"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="196"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="419" mass="47036" checksum="D455068F29990400" modified="2017-08-30" version="1">MRPVQRYRWSTGGILKSFRYACTLAEPPEIPLPRIQPKPGTDMRVLYIGAGNINFGSEEGPWNHSQRLEQILGARLNVVGVVDPMTARAESVLEAKRLTVARPAYQRTTVFPTIQEAAKALSSSPPHIVIVGSPPAFRGQMQQPNNAEEQLSTAFPSAGMFVEKPVSTGAVEQATMVGKFLESRKENIVSVGYMLRYSAAVQKMQQIIKDNGLTVMMTSGRYVMAYEASRKLAWWNKAVDCGPIVEQATHFVDLSRYFGGEIDLPSIAAHSIEWYERPGQLSKIRVDESKIPEDQRIPRFTSATWKYDKGAIGHLEHGVALQGQTFSTEFTVFADGYQMKLIDPYNRPTLYLRQPGSDTEQIMTFHDDDPFLSEMASFIDTVEGVEPKIPILSSYEDAVRTYEATWSIRWASEKTRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCF0</accession>
    <name>A0A1Y1UCF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-sugar transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_581827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869885.1">
        <property type="nucleotide sequence ID" value="XM_022013526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCF0"/>
    <dbReference type="FunCoup" id="A0A1Y1UCF0">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCF0"/>
    <dbReference type="GeneID" id="33555334"/>
    <dbReference type="InParanoid" id="A0A1Y1UCF0"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="663" mass="70884" checksum="F82059DCCA64F5C8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCW4</accession>
    <name>A0A1Y1UCW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_633160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869131.1">
        <property type="nucleotide sequence ID" value="XM_022016603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCW4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCW4"/>
    <dbReference type="GeneID" id="33558412"/>
    <dbReference type="InParanoid" id="A0A1Y1UCW4"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF84">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="329"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="667" mass="70551" checksum="381B715AF853984E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD13</accession>
    <name>A0A1Y1UD13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_609183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870070.1">
        <property type="nucleotide sequence ID" value="XM_022014145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD13"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD13"/>
    <dbReference type="GeneID" id="33555953"/>
    <dbReference type="InParanoid" id="A0A1Y1UD13"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF7">
        <property type="entry name" value="PROTEIN STB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="859" mass="94557" checksum="80A8A7419F0C597C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD23</accession>
    <name>A0A1Y1UD23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1680 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869606.1">
        <property type="nucleotide sequence ID" value="XM_022016552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD23"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD23"/>
    <dbReference type="GeneID" id="33558361"/>
    <dbReference type="InParanoid" id="A0A1Y1UD23"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="50"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="575"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="78717" checksum="8F3A1B0460C136DA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD35</accession>
    <name>A0A1Y1UD35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870051.1">
        <property type="nucleotide sequence ID" value="XM_022018401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD35"/>
    <dbReference type="GeneID" id="33560210"/>
    <dbReference type="InParanoid" id="A0A1Y1UD35"/>
    <dbReference type="OrthoDB" id="2561733at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="601" mass="65892" checksum="18B31A588B026450" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD48</accession>
    <name>A0A1Y1UD48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_512747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870082.1">
        <property type="nucleotide sequence ID" value="XM_022012967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD48"/>
    <dbReference type="FunCoup" id="A0A1Y1UD48">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD48"/>
    <dbReference type="GeneID" id="33554775"/>
    <dbReference type="InParanoid" id="A0A1Y1UD48"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122804" checksum="CC18FCCBD4CBE35F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDC4</accession>
    <name>A0A1Y1UDC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869711.1">
        <property type="nucleotide sequence ID" value="XM_022016342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDC4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDC4"/>
    <dbReference type="GeneID" id="33558151"/>
    <dbReference type="InParanoid" id="A0A1Y1UDC4"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="170" mass="18603" checksum="0F95A73B88396E17" modified="2017-08-30" version="1">MSLLRSPAPPAHMLRASMAARRALSSSPVPRQEVVTPAVGTVGSLPPPRRGGFRGGILGFLFGFSLAGSLALYYLNQEREVASGLLIASIDELQQSTGKITSHLDRLQQVEKEVASLKSSMAQRDDVVKVRGEMKKVYDGLHLELLDMRAHVWGVEQDLQKVVKTESIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDG6</accession>
    <name>A0A1Y1UDG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_630651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869728.1">
        <property type="nucleotide sequence ID" value="XM_022016350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDG6"/>
    <dbReference type="FunCoup" id="A0A1Y1UDG6">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDG6"/>
    <dbReference type="GeneID" id="33558159"/>
    <dbReference type="InParanoid" id="A0A1Y1UDG6"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="423" mass="47383" checksum="EC8332EAEB972E35" modified="2017-08-30" version="1">MDNTPRQLFQTASNVYVLQQPWAFVKELGQGAYGCVSSARNAHTGETCAVKKVTNVFTKKILTKRCLRELRLLHHFRGHKNITCLYDMDIIFDPPGSGLFSEVYLYEELMEADLHAIIRSGQPLSDAHFQSFLYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFQPGAVQTDQGQAGFMTEYVATRWYRAPEIMLSFANYTSSIDMWSVGCILAELLGGKPIFKGEDYVDQLNKILNLLGTPTEDTLRRVGSPRAQDYIRSLPIKARVQFKVLYPNAQPLALDLLTKLLTFDPAKRIGCQEALEHPYLSVWHDPADEPLCEVPFDFSFEREESTHGMRDLIVDEVRSFRYLVRQQSAPAPPRTHELPPVPAASQQPGAGIGPAYSDDPNVGADVDEHPSSALERQLGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDT4</accession>
    <name>A0A1Y1UDT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_652375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869425.1">
        <property type="nucleotide sequence ID" value="XM_022018478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDT4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDT4"/>
    <dbReference type="GeneID" id="33560287"/>
    <dbReference type="InParanoid" id="A0A1Y1UDT4"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="757" mass="84349" checksum="4C875AE2E8758495" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE07</accession>
    <name>A0A1Y1UE07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_632311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869505.1">
        <property type="nucleotide sequence ID" value="XM_022016509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE07"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE07"/>
    <dbReference type="GeneID" id="33558318"/>
    <dbReference type="InParanoid" id="A0A1Y1UE07"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="77"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="548" mass="58595" checksum="D92DB47CD5FE2D2C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UED8</accession>
    <name>A0A1Y1UED8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_651653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870514.1">
        <property type="nucleotide sequence ID" value="XM_022018366.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UED8">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UED8"/>
    <dbReference type="GeneID" id="33560175"/>
    <dbReference type="InParanoid" id="A0A1Y1UED8"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="880"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1676"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2374"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2408"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2578"/>
            <end position="2606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2418"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2578"/>
            <end position="2590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2606" mass="290761" checksum="9AAFF743C1128210" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UED9</accession>
    <name>A0A1Y1UED9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_494795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870499.1">
        <property type="nucleotide sequence ID" value="XM_022012939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UED9"/>
    <dbReference type="GeneID" id="33554747"/>
    <dbReference type="InParanoid" id="A0A1Y1UED9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="149" mass="16661" checksum="F353240F8943B42A" modified="2017-08-30" version="1">MSTLTHLIIYFQTNLPSDPPKLLRRHVCNGLSEIRFSRTSERSQSMSCTSASQVKLTQSQILMRIMIALGARSSYHPAIIPGGDVAFPFTLGLSREAPCRALARTVLERFYELNIRKQPTIESIQIAASVYLITRSEPETGRITCSLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEJ4</accession>
    <name>A0A1Y1UEJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_500195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870581.1">
        <property type="nucleotide sequence ID" value="XM_022012951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEJ4"/>
    <dbReference type="GeneID" id="33554759"/>
    <dbReference type="InParanoid" id="A0A1Y1UEJ4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="248" mass="24885" checksum="0E07CBB32BC745E8" modified="2017-08-30" version="1">MTSPFNPFINPSTGLTPVPAGSSPFPLPSFPSPFPVFGSQPLGQSPLAQSGGLGAGTAAGAGPSTNAGLGLGQTPFLGSTPNAVQTNGQSPFPVFNIQPAAESTSPFTFMANAAGAGTPSGGILATGTPGTGPGGGLNVASGSRLPSLAWNNAASRRMAPPASSTGAGSTRAGVEDMMRGLGEAEKMMERAIVVATEIQRLEGSTFEDNQGKEKSEGMELGPSGLPKLEELVFECEFCAYSSLSCDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEK6</accession>
    <name>A0A1Y1UEK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="5 10">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_580957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 10"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870553.1">
        <property type="nucleotide sequence ID" value="XM_022013476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEK6"/>
    <dbReference type="FunCoup" id="A0A1Y1UEK6">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEK6"/>
    <dbReference type="GeneID" id="33555284"/>
    <dbReference type="InParanoid" id="A0A1Y1UEK6"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="201" mass="21842" checksum="5DFC18925263468C" modified="2017-08-30" version="1">MDRSASVSRETSETQITCSVNLDVEPGVKEQVIEVSTGIGFLDHMFTALAKHGKMSVKLSCQGDLHIDDHHTAEDCALALGEAFKKALGERRGIARYGYAYAPLDESLSRAVVDISSRPFFECHLPFTREKVGDLSTEMIPHLLQSFAFAAGITLHVDYIRGTNNHHIAESAFKALALALRMAITRTGGNDVPSTKGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEW4</accession>
    <name>A0A1Y1UEW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_651073</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870652.1">
        <property type="nucleotide sequence ID" value="XM_022018260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEW4"/>
    <dbReference type="GeneID" id="33560069"/>
    <dbReference type="InParanoid" id="A0A1Y1UEW4"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX36583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="109" mass="12109" checksum="18A573CB9917B2E3" modified="2017-08-30" version="1">MTSQADDPSSLPPAHQLLLQKQREHLGLLQLRDASKDLLERVEKLAEMNHIMADGGEAIGQVMKNWPHVFGILNLFDKPPGETRADEEAEPIPTLVRIPYTSTEEPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF34</accession>
    <name>A0A1Y1UF34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase Rpb7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_630368</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870276.1">
        <property type="nucleotide sequence ID" value="XM_022016321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF34"/>
    <dbReference type="FunCoup" id="A0A1Y1UF34">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF34"/>
    <dbReference type="GeneID" id="33558130"/>
    <dbReference type="InParanoid" id="A0A1Y1UF34"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="174" mass="19328" checksum="B520223F183782A0" modified="2017-08-30" version="1">MFFLRQLSHTILLHPSYFGAQLEDYIRKKLYEDVEGTCSGKHGYIISVVQIISTGEGKILPSTGQARFRCTYTAVVMKPFKGEVVDGKVANVNKMGFFAMVGPLQVFVSSHLVHADMKFDPNASPPCYRSSSTDETITKDTKVRIQIVGCRVEANDIFAIGTIRADYLGQLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF44</accession>
    <name>A0A1Y1UF44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_626835</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870760.1">
        <property type="nucleotide sequence ID" value="XM_022015934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF44"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF44"/>
    <dbReference type="GeneID" id="33557743"/>
    <dbReference type="InParanoid" id="A0A1Y1UF44"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="227" mass="25240" checksum="87FC47B6BE1252E7" modified="2017-08-30" version="1">MSLIHALVARGTTVLAEHATGGAELKPAAQITILSKIPPNNSKLTYVWQDRLIHYVSSDGVIYLVMADDSVGRRMPFGFLAEVERKFTSMFSSDMVISAGGHSLDHEFEPELKKLMDQYTANPPSDPLKQAKTDLDNVKDIMVQNIDSILQRGERLDLLVDKTDTLAGQAYAFRRGARSVRRQQWWRNQRITVLTGVVCVLLFYILLAQFCGASLTECGADHSGEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFF6</accession>
    <name>A0A1Y1UFF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_627072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870827.1">
        <property type="nucleotide sequence ID" value="XM_022015959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFF6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFF6"/>
    <dbReference type="GeneID" id="33557768"/>
    <dbReference type="InParanoid" id="A0A1Y1UFF6"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="552"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="980" mass="105796" checksum="F705E1411505FB43" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG81</accession>
    <name>A0A1Y1UG81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871091.1">
        <property type="nucleotide sequence ID" value="XM_022015718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG81"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG81"/>
    <dbReference type="GeneID" id="33557527"/>
    <dbReference type="InParanoid" id="A0A1Y1UG81"/>
    <dbReference type="OrthoDB" id="2564865at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="845" mass="91621" checksum="0C1BF497D486DFAE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGG6</accession>
    <name>A0A1Y1UGG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_656282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871107.1">
        <property type="nucleotide sequence ID" value="XM_022018839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGG6"/>
    <dbReference type="GeneID" id="33560648"/>
    <dbReference type="InParanoid" id="A0A1Y1UGG6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="156" mass="16237" checksum="6D8721EDA6D573CF" modified="2017-08-30" version="1">MALRMDDSDKLANNVKPGGMQSTGEHAQGVLDTAASYLPGQSKPGDALNDDAASPNMTHDTGRQGGLDAFKTSGNQGPIDYLKTKMDQGASNVQTDKSATQQLRDTMTPGNAGIGEQPNQGPGLMDRAAGAMNSVKESIMGPGHDSPVSVTRHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH84</accession>
    <name>A0A1Y1UH84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-1-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_625783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871387.1">
        <property type="nucleotide sequence ID" value="XM_022015840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH84"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH84"/>
    <dbReference type="GeneID" id="33557649"/>
    <dbReference type="InParanoid" id="A0A1Y1UH84"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="25973" checksum="71CA6A9B28E82037" modified="2017-08-30" version="1">MGHKSETTAKCLLFDMDGTLIDSTPAVDSVWEAIAKKYDLDLKEVLKTCHGRRTVDSLKKWCGITDPEELEKEVNHFESMIVTRSKELKDEGKRGLEILPGVKEMLETLNDSHKPIWAICTSATSAYAGDAIPSTGLPKPPHLITAEDVHEGKPDPAPYIAGAKALDVECKDCIVFEDAPSGIKSGVNSGARVLAVCTSHKRDQIENLGAEWIVTDLTKVKIRVEDSIVHLEIDETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHJ8</accession>
    <name>A0A1Y1UHJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I phosphodiesterase/nucleotide pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_680950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871045.1">
        <property type="nucleotide sequence ID" value="XM_022019101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHJ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHJ8"/>
    <dbReference type="GeneID" id="33560910"/>
    <dbReference type="InParanoid" id="A0A1Y1UHJ8"/>
    <dbReference type="OrthoDB" id="2118639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="505" mass="53907" checksum="E61942280E429D1E" modified="2017-08-30" version="1">MLALHLLLAQPAAARVLPRDIVDPGAPALTYPLTGMSPVGNPPFYSPENVNAAYQHAVYLSIDGMHQSDLEWYVSTFPQSTMASLLQNAIEYTNARCPSPSDSAPGTVSPATGCSPRTHGVYYDDAYDGSLYPPGSNCTGPIGTQTGWDETLDLNNTVLNGGGGFNESMFPLQLTASGYCAAVKPWDFLRVNTMFEVIREQGLVTAYTDKHPAYSMLNGPSGLGLTDGFFPEINAVSGQQETEGYDDLHWSALTNWTMGNYANGTSGLGVPSVYGANFQSVSVSQKAYGYNSELVPTANLTQAFRQVDTRLGQLVDTMKSVGTFDSTLLIIYAKHGQSPINSTLVRKIPHPTLLNVIGVPTVQDASDDASYIWLQDKNDAAQAKANILANATAVGAAEVWIGADIVANGFGNPWFDSRTPDVIIKTEPGVIFTTGKKIAEHGGLNADDHDVVLFVSNPVISASKCDEVVYTRQIAPTFIKALGFDPLLLAGVRAEGTLPLPGVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHP2</accession>
    <name>A0A1Y1UHP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_673725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871044.1">
        <property type="nucleotide sequence ID" value="XM_022018943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHP2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHP2"/>
    <dbReference type="GeneID" id="33560752"/>
    <dbReference type="InParanoid" id="A0A1Y1UHP2"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="386" mass="42249" checksum="1AF19B01BD185928" modified="2017-08-30" version="1">METSKERTIVVLGASYGGFRAAQILAESLPPEWTLIVLERNSHMNHVYVFPRCALMAEYAPRAFIPYDNLFPALSPERCRAVLIHATVLGMTSHSVRFQRHGASETEKMDFTYAIYALGSGMPGPVNIWTSDHGLGNGSTGTKRHGITWMEQQSQMFVNARDVLIVGGGALGIQFATDLKELFPHKDVTLLHSRYRLLPKYPVAVHDMCVKRMADMGILTVFGQRVHTWPVNKPGRKKVQTETGAVYEADIVLCCTGQKPQIAILAAMSPLSINQETGRIAVLPTLQLASPRGQLLSHIFAVGDCADTGAIQAGNTAYRQAEVAAKNILGLVKGLQTGDVPELQNYHPGKPMIKLSLGIKTLMNATGEKIEVTENGKEDLDALSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI48</accession>
    <name>A0A1Y1UI48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Smg-4/UPF3 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_623055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871717.1">
        <property type="nucleotide sequence ID" value="XM_022015544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI48"/>
    <dbReference type="FunCoup" id="A0A1Y1UI48">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI48"/>
    <dbReference type="GeneID" id="33557353"/>
    <dbReference type="InParanoid" id="A0A1Y1UI48"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="380" mass="40085" checksum="B3706968AB5B4885" modified="2017-08-30" version="1">MSPAGPSKTEPAIRSKLVIRRLPPNLPENIFWTSVEPWVHAETCLWKRFVPGKAGDGRDQRPVFSRAYVLMASPEALVNFHRGFDGHLFRSKTGEEYQAVVEFSPVQKTPYKAKVKTDARQGTIEEDPDYKSYLDSLSAPPTAPAEEVSKPSGSAPVPTSTPLLDHLRALKKAKKKKDPSVKEAALSAVTKAAAKRAPQQPNVVMVAGPGRDVKVAPAEEGKKKNKKKAKGEAAGSGPKDAAKGSKQQQDAAAPPPSISRSTAPAKEKAQQDPSAQPARGLTKASNDATNPPREAGARGRGRGRGQGQVHEGSGRSARGAVMEILSKNAEGEKGGGRGGRSRGRGRGTPSSTVAAPGPARGEEASASETSLAARQERIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIZ8</accession>
    <name>A0A1Y1UIZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_624229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872008.1">
        <property type="nucleotide sequence ID" value="XM_022015671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIZ8"/>
    <dbReference type="GeneID" id="33557480"/>
    <dbReference type="InParanoid" id="A0A1Y1UIZ8"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025442">
        <property type="entry name" value="DUF4185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13810">
        <property type="entry name" value="DUF4185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013073194" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4185" evidence="2">
        <location>
            <begin position="231"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="401" mass="43782" checksum="B42E4F8C8675FF40" modified="2017-08-30" version="1">MLAQVLVALATSALTLAAPTKTENRRSAASPSIASVETVAITLNPHLQRDSCISASELINDRVLWLCRDTLILEDETLNDYQDLPVSSTVGWSDMSNGSPLLVPIPADQGDKPITQPFSKQLTLYGQNESSPFLYYAADQCPSSGQCDGPGAVRNVEWPDAPLYITNTASDGTVTGYMYSTRGVTGDNQPATTLYEVTYTPGDDPLALPTATMIAEEFFPRFAWNYGAMGGIIDDGYLYLWGVTYDFGVFNNNQTVGLARVPVGSITNINDYQYYYPSTSTWSSVQPNIYDASANVNIDGIFGQGTFFYSSYYGRYVYVGQLGTIDGEMLIAAATASSPEGPWSAQSNQYQIDPDYSYSLAAHPEMSGNLPSNQIYLTYTQNVKYDNDNQYVTPLLIMTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ60</accession>
    <name>A0A1Y1UJ60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871574.1">
        <property type="nucleotide sequence ID" value="XM_022018108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ60"/>
    <dbReference type="GeneID" id="33559917"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ60"/>
    <dbReference type="OrthoDB" id="2565232at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="454" mass="48971" checksum="F9EA6FBCC706F2E5" modified="2017-08-30" version="1">MVSPAHGQELNSLPSTPLTPSLSIVDSIESDSAPRTPASMNILLDAVDVEPRALRDDRTDSSSNVSGSELGDDDTIRLLVDPHATPTQEGRYQSSSEGVEGEQAGADDDMFPSTASHESQATRQRVDQIRPPQPAHDPSEPVRITSGPPVGWRSTIPASPPLSTQDPLTQTRVSPVSGEAPANAGLDQQHDLRRSRETFIPGQVNSRLSMTVKGRTVSGAMQHAMHRVEQTDQASDSAGYKGPGERPSSFDLQSTTTSQQDEEIWMSYVRDQLAALFPDFFDPSEYSSSHDGGSSAIMAQARSQAEGIARDEVAQRLDSNQSQEKGGTAIDIGWNVIQDRGHRRALTSNRVPSVTNVKIGMRDESTSVGTNTGELGNGSEDDDGRPPTGDDIDREIQSRSGDLSSSQIMTPEALTLIRSIDHLFRGEVREDGHIFESSNLVRLNLSVSEKIPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJN2</accession>
    <name>A0A1Y1UJN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_393229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871701.1">
        <property type="nucleotide sequence ID" value="XM_022012671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJN2"/>
    <dbReference type="FunCoup" id="A0A1Y1UJN2">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJN2"/>
    <dbReference type="GeneID" id="33554479"/>
    <dbReference type="InParanoid" id="A0A1Y1UJN2"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="124"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="343"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="575"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123168" checksum="9AE2E5639736571D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJP3</accession>
    <name>A0A1Y1UJP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_679962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872124.1">
        <property type="nucleotide sequence ID" value="XM_022019059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJP3"/>
    <dbReference type="GeneID" id="33560868"/>
    <dbReference type="InParanoid" id="A0A1Y1UJP3"/>
    <dbReference type="OrthoDB" id="2589196at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="199" mass="22356" checksum="B034059624E5C433" modified="2017-08-30" version="1">MSYIPRNRFQASDCLEGHVLIGVFLSVSSIVVLCLTSFSIPYIKNIFFLSTSTGYKYGTLGYCQFGSCSRRRIGYETGREIIHWLTQTLVLFPIAALLIFLGLWGLVWSLWGPSKNSIWFRIPTAVGALTALVAEIFALVLFVTARNRFHESAIDTAYGPALWLGIAGFICAATSAFFCGPPYTARYMYRAHRDYPTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJS7</accession>
    <name>A0A1Y1UJS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_650981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871423.1">
        <property type="nucleotide sequence ID" value="XM_022018243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJS7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJS7"/>
    <dbReference type="GeneID" id="33560052"/>
    <dbReference type="InParanoid" id="A0A1Y1UJS7"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="220"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="220"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="934"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109732" checksum="85BCAC44634734F9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJT8</accession>
    <name>A0A1Y1UJT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_620454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872252.1">
        <property type="nucleotide sequence ID" value="XM_022015284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJT8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJT8"/>
    <dbReference type="GeneID" id="33557092"/>
    <dbReference type="InParanoid" id="A0A1Y1UJT8"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="455" mass="49722" checksum="793D46DB90834470" modified="2017-08-30" version="1">MSAASKMPVPTPRQFRILALPLARLPRTASTTQIKPAPTDASSPTPPLSPHSVDGASESSGTSSHGEGSTASASSSSPPANTSHPSSSSTPLLFFHVIQPSPSPSQSPPPLTTRILSKASDTWIKLGEKDPKSWMHWFYRKGESLMDRIEYEEWALKAVHEGRGVKVLKEGEEKTKTQEIIEIPLLKPTLTEKGVQLPTMLPKLHRMLIHRIPYHRKMMIRSLLFTPVTFPFAIIPVIPNFPLFYVLWRAWSHYKAWRGAFYLERLLKLGMIKEQTSEELTKVYASKGQVVPEPGSENRAPDQTFSETSVSIKSSSTTTTSPDGTHEAQSTEKIPSQAKGAGPAPDGTSTPESMVFSPPQNSTDKPTTGSTPRPTPAPRHPSLLLSPSQVPLLAKTFDIKGQELMDVVRAVEQADGRAWAADKKRGGESQQGDAAQPSGSDDKKPGTNWRGNLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJX3</accession>
    <name>A0A1Y1UJX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_641552</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872275.1">
        <property type="nucleotide sequence ID" value="XM_022017428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJX3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJX3"/>
    <dbReference type="GeneID" id="33559237"/>
    <dbReference type="InParanoid" id="A0A1Y1UJX3"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="14">
        <location>
            <begin position="723"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX38353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="805" mass="88038" checksum="EA24FC47B44912A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJY0</accession>
    <name>A0A1Y1UJY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_680041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872214.1">
        <property type="nucleotide sequence ID" value="XM_022019065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJY0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJY0"/>
    <dbReference type="GeneID" id="33560874"/>
    <dbReference type="InParanoid" id="A0A1Y1UJY0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43705" checksum="7E632FBD01BA0483" modified="2017-08-30" version="1">MHTVPPGSNSPTAGSTISEIMLRHDTGHKDDNTDTFNDGATETDNRSLMTFCKSIPFTCRDVRTMAHHMDSDSATFSMTSSMENAIFREDAGRRFQATNDDYSLPADELEFARLDYQHFGLKARASPTQLYHDKNYLAPIPEALKDDGTGQRKRGLDIGAGTGIWAIEMAQEFPSVDWTALDLIPVQRDGTPDNLHFMQEDASIGIGFPDDYFDCVHARALIAGMRNWPKFIEEVIRVTRPGGLVVFIEPNLPMGLYKSTAEETRAVTPGAYAFADVMARAFTRRGYDINAASKTILSVLKANDLVDRVEQVEASFPCSPWAVEPNWKKSGIMMKFNAISVPETTKVLIMDAMEMPQYQVEALGKAYVEDIEAGHRLVYPIYHNWAWKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK87</accession>
    <name>A0A1Y1UK87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_620748</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872331.1">
        <property type="nucleotide sequence ID" value="XM_022015319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK87"/>
    <dbReference type="FunCoup" id="A0A1Y1UK87">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK87"/>
    <dbReference type="GeneID" id="33557127"/>
    <dbReference type="InParanoid" id="A0A1Y1UK87"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000001">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="35823" checksum="B3EF64CE205AFA9B" modified="2017-08-30" version="1">MASAAYANIKLFSGNSHPELAALIAKRLHIPLARATVVQPGSGETKVTITESVRDFDVYILNTCAGEVNTSLMELCIMIHACKIASARRITAIIPHFFYARQDKKDKSRAPITAKLVANMLREAGCDHVITMDLHASQIQGFFDVPVDNLYAEPLMVDYIRNHFDDVRDVVIVSPDAGGAKRATNIADKLNVDFALFHKERKRANEVSRMVLVGSVKDKVAILVDDMADTCGTMGLAARNLIESGAKKVYSFATHGILSGPAIKVINESGMEKLVVTNTIPLADRAAECSKIEQIDVSHVLAETIRRSHFGESVSYLFHEVPYSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKB8</accession>
    <name>A0A1Y1UKB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_578083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872361.1">
        <property type="nucleotide sequence ID" value="XM_022013301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKB8"/>
    <dbReference type="FunCoup" id="A0A1Y1UKB8">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKB8"/>
    <dbReference type="GeneID" id="33555109"/>
    <dbReference type="InParanoid" id="A0A1Y1UKB8"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="51"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="315"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67765" checksum="868726E280D65001" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKH2</accession>
    <name>A0A1Y1UKH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_361537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872421.1">
        <property type="nucleotide sequence ID" value="XM_022012581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKH2"/>
    <dbReference type="GeneID" id="33554389"/>
    <dbReference type="InParanoid" id="A0A1Y1UKH2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="99" mass="11612" checksum="A37322302F17AC56" modified="2017-08-30" version="1">MTKGLCFFFDSVWLIGLLDASHSKFLYKQSPSQLFIIFFPILRFNHLTHLIRTRHPRHILTIDESGSVIFTRNDIFASTYRILDRGRDLTDPHTLISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULB0</accession>
    <name>A0A1Y1ULB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPI transamidase component PIG-T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872198.1">
        <property type="nucleotide sequence ID" value="XM_022018031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULB0"/>
    <dbReference type="FunCoup" id="A0A1Y1ULB0">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULB0"/>
    <dbReference type="GeneID" id="33559840"/>
    <dbReference type="InParanoid" id="A0A1Y1ULB0"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012056149" evidence="3">
        <location>
            <begin position="17"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="577" mass="64411" checksum="FDC07C3364DB52D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULC2</accession>
    <name>A0A1Y1ULC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_294140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872711.1">
        <property type="nucleotide sequence ID" value="XM_022012401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULC2"/>
    <dbReference type="GeneID" id="33554209"/>
    <dbReference type="InParanoid" id="A0A1Y1ULC2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46571" checksum="05291AC6A24E7D4B" modified="2017-08-30" version="1">MLQSKVRARRARVYKIPDTPPKTSRPLPLDILRRIFSFLDPIHDAKARPALAISLRVSHAIHDLVAPLLYREVSLHWLVNQDVVWKAGTQDTYYKIRKRNPAPRYTLPAHYIQYIRHLYVHHHTHKNIRSACRLQLPPALVHMDILELEIATRNRYARTRRDWCNDITPHSRRNGNVNRCPGIRFFRPRTLLLICEDLFVNDSDEAFCDVSRLPEVTLQALRRLVIRPRRCALEDIFHGYGADDHLRFGKIPTSTQRIDVVFEPSIAGLRRPRNGGPPSILDRQRLQTVMFEDLLSLMFAAPRREPPGYQVTIVGIGYLGDDIDPLHDPGASGRCSEAIQVAVEARVRMIAITKHGDSPETRATLDKMRFLDLRTYAAELRGIDKHILSAECWNHSELDPLFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULK5</accession>
    <name>A0A1Y1ULK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_620582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872288.1">
        <property type="nucleotide sequence ID" value="XM_022015299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULK5"/>
    <dbReference type="GeneID" id="33557107"/>
    <dbReference type="InParanoid" id="A0A1Y1ULK5"/>
    <dbReference type="OrthoDB" id="2332199at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="290" mass="31417" checksum="DB6D5FC2C7DCEDF8" modified="2017-08-30" version="1">MSQPRPSVEPLLPRPATATQDSDNADEDEFQPQGLLSNMGISISTARWLAPASFIFDFACQMYGMNSSPNMKQIHDRHPAAFSPQPFAIAGFFGPQQIAQLLWLRELYRSDAEVERGTVRYVPWYALGNAMIGIWMFLWNGDNMKGADIPVIINTLTQVYYMLYLRDPAPNTYQAKLTNIINITFAGIGILDIFHNTSVAWFEGVTPNALTTIGTMAAAPLTALFSPLLFGACIAYDLFGVAIGQHQLAQKALDGLGGGGGEGWAKLMGGLGLGVAAIVGARGWGGARWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULP4</accession>
    <name>A0A1Y1ULP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_620697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872318.1">
        <property type="nucleotide sequence ID" value="XM_022015312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULP4"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULP4"/>
    <dbReference type="GeneID" id="33557120"/>
    <dbReference type="InParanoid" id="A0A1Y1ULP4"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="84"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="469" mass="52170" checksum="0AEF8AB0C52DCE3E" modified="2017-08-30" version="1">MSTEADDTEQHQAPAPAYSALPSQKTRKSLSAKLCWIIIFLLGAFAVLLLSSTRRDSLSPFEQLRTLFSSQNRHTVLVPEMSAKKHVGYFVNWGIYGRKYPPQQIPYQHLTHINYAFGNVNKESGEVVLSDSWADVEIHYEGDSWNDSGTNLYGCLKATYLLKKKNRNLKVLLSIGGWTYSPNFAGIVNPQWRQNFVRSAVKLVEDVGLDGLDLDYEYPKTSADADGYVRLLHELRQGLEELAASKGRPRGQYQLSIAAPCGMDNMQVLNVKAMGQVLDFWNLMAYDFAGSWDSVAGHQAALFSAYPGAPSIDAAVRFYTSQGVHPSRLVIGMPLYGRAFANTDGIGASYSGTGEGSWEAGMWDYKALPLPGSEEVNDHRLGASYSYDRGKRLLISYDTPAIAIQKAHFINQNGLGGAMWWELDADKAEDTGLNLVRTVKEQFGQLEYRENDLHYPGSKYENLRNGMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULS1</accession>
    <name>A0A1Y1ULS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_624409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872062.1">
        <property type="nucleotide sequence ID" value="XM_022015699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULS1"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULS1"/>
    <dbReference type="GeneID" id="33557508"/>
    <dbReference type="InParanoid" id="A0A1Y1ULS1"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="140"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="377" mass="41814" checksum="2BCD7424A6CFCBCE" modified="2017-08-30" version="1">MSSTTMSPVKVGIIGYGNSARVFHLPHILSVPELSLVAFFQRARASNDDKPKSSDDYPNCKHYHDFDKFLADENIELVVVTTRDDSHADLSIAALEAGKNVVCEKPLGQTSEQVLRMLEAQKRSGKILFPFQNRRYDSDFRTVQRVIQSGALGDIHEMALHYDWDLPAWIAGMGDKPYTPGAGMMFGIGCHKLDQALALFGRPSTVTGFYRALRPGAGDSKIDDTFTIVLHYPKSGPHRNLEVVVKCNVINKTKHQFAYFVRGTKGSFLKLGEDPQEAQVQSGMKPSDEGYGEEDEDIWGDLASEDRANDSQVKRGSLWCGKVKSEKGSWGMYYRDVAKAVRGDPVVVKAETSADGIRIIELARESAEKGRSMVFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULV1</accession>
    <name>A0A1Y1ULV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_620987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872396.1">
        <property type="nucleotide sequence ID" value="XM_022015348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULV1"/>
    <dbReference type="FunCoup" id="A0A1Y1ULV1">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULV1"/>
    <dbReference type="GeneID" id="33557157"/>
    <dbReference type="InParanoid" id="A0A1Y1ULV1"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="46637" checksum="C2A95C7D6FB9F0B4" modified="2017-08-30" version="1">MASKKSRLDLLLRVRYLNPIPQPPFPPKLFNLSTNVNRLGEPSYLDDLVSSTPLPMLVDSEMGMPVDLNVYERVWNGNDEELGLAETQDLAAEDLALIAPFEDVKPQINGSGSAAGSTDVTWMRNSALFTRKAVSGSKSLTAIAKDEEVDASTAAQIMSIEQTFSEFDSQDVTQLKHPDPKRSRLRVVEQYEILPEDEAWSNSYIMMRYPERPTASTSANPHAEASSSRLNRAVLRPVMEDDQQIMQFLLPEEDTLPRLEHSFVDPIGNESYEQMKELTMNDPNDPQIDSVFPSALYDQIRTYEVVSQTRPQKEVLITIVEAGDPAKAQGAYYKEIGTRAQLRKTRAKRQGEGDETQEPLWDKSRVGFRHPHEDLISQRATAQAMVSDPGWIEAQLRGLGDGDNEAVGQGEAIKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULW7</accession>
    <name>A0A1Y1ULW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose mutarotase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_576867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872911.1">
        <property type="nucleotide sequence ID" value="XM_022013220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULW7"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULW7"/>
    <dbReference type="GeneID" id="33555028"/>
    <dbReference type="InParanoid" id="A0A1Y1ULW7"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801863" evidence="4">
        <location>
            <begin position="25"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="402" mass="44612" checksum="36884F80F47183B2" modified="2017-08-30" version="1">MKFTNLVSFAALSASTLFPSVAQAWNQGSVDGTDPFQPYTIYAYGINATFIGYGSRLTSLFVHDKNNIPREVVVGYDDPHQYLIDTETNRTFFGAIVGPYANRIKNGTFNIDGETFHVPENEHDGEDTLHGGFDGYDTRNWTMTQYNTSSITFTLYDSSGTGGFPGTKISHVTFSLSDATANSRGKLTGRMVTVALDQPTPVMLASHIYWNLGAFQSTTILNDTLWMPNANRIISIDGIEVPTGGLQSVKYPFQSPSVPLNFTYPKQVYEGVLYSQQCGTGCTGIDNAFILDRPPYDGPESTSDVQLQWQSPDTGITLKLRTNQQSLQIYTCNGQNGSIRSHASQGNPKIEKYGCLVVETQQWIDGINQPEWGQLDRQIFGAMTGPAVNWLEYEFTTEEWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM49</accession>
    <name>A0A1Y1UM49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_621352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872478.1">
        <property type="nucleotide sequence ID" value="XM_022015375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM49"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM49"/>
    <dbReference type="GeneID" id="33557184"/>
    <dbReference type="InParanoid" id="A0A1Y1UM49"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174">
        <property type="entry name" value="DUF946 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48174:SF5">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010995087" description="Vacuolar protein sorting-associated protein 62" evidence="2">
        <location>
            <begin position="22"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58402" checksum="99989B87BF176AAA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM56</accession>
    <name>A0A1Y1UM56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-lactaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_577591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872496.1">
        <property type="nucleotide sequence ID" value="XM_022013268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM56"/>
    <dbReference type="FunCoup" id="A0A1Y1UM56">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM56"/>
    <dbReference type="GeneID" id="33555076"/>
    <dbReference type="InParanoid" id="A0A1Y1UM56"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="345" mass="37645" checksum="AA6D73C104D9038D" modified="2017-08-30" version="1">MPVISKGNLVLVTGASGFVGSHVSQHFLKGGFKVRGTVRSESKGEYLKKLFKNDGDFDYVIVDDIAKDGAFDEAVKGVDAVAHTASPFYVTNIKSTDELIQPALHGTTGILKSIQKNNPDVKRVVVTSSVSAIMCVASKKAPYTYTEKDWNVDSVGIVEEKGVDAPGLHIYNASKTLAERSLWDFVEKNKPNWEAVTINPPVIFGEIIHECPTPEKLNTSVARVYEWAAGKKTEKDLPAAGGNWVDVHNVAEGHVLALTKPDAAGERFIVGNGPFAGQDICDVIHKRFPDLKDVPVGKPGTHDEITKDANVFDGSKAHKELGIQYVSLEDSVYQTVKSVRERFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMF9</accession>
    <name>A0A1Y1UMF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_650005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872578.1">
        <property type="nucleotide sequence ID" value="XM_022018076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMF9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMF9"/>
    <dbReference type="GeneID" id="33559885"/>
    <dbReference type="InParanoid" id="A0A1Y1UMF9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011833673" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="543" mass="58911" checksum="CDCEDE368DF05E26" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMH6</accession>
    <name>A0A1Y1UMH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1754-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873113.1">
        <property type="nucleotide sequence ID" value="XM_022015110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMH6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMH6"/>
    <dbReference type="GeneID" id="33556918"/>
    <dbReference type="InParanoid" id="A0A1Y1UMH6"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13581" checksum="0AE3F307E67594F4" modified="2017-08-30" version="1">MSDYAHRPGGKLKLKGEGEKKKKKKSHSSSDRAKVDAEISQKEKERERETQEVEERPTGRKMTDAERRFEEIQRKRREERALKNAKMSHKDRVQEFNQRLDSLSEHHDMPRIGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UML6</accession>
    <name>A0A1Y1UML6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_618996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873112.1">
        <property type="nucleotide sequence ID" value="XM_022015109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UML6"/>
    <dbReference type="FunCoup" id="A0A1Y1UML6">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UML6"/>
    <dbReference type="GeneID" id="33556917"/>
    <dbReference type="InParanoid" id="A0A1Y1UML6"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="93" mass="10516" checksum="A4FE32BDDD8CEA55" modified="2017-08-30" version="1">MSATAGAQVPQAQFDAATQRELQEFIDQEQAKAKMAATVHELTDTCWKKCVTGSISSKFSRNEVSCLENCVDRFLDTSFYILNEVKQQRNQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMS4</accession>
    <name>A0A1Y1UMS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain-containing oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_619156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873155.1">
        <property type="nucleotide sequence ID" value="XM_022015131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMS4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMS4"/>
    <dbReference type="GeneID" id="33556939"/>
    <dbReference type="InParanoid" id="A0A1Y1UMS4"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF64">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="325" mass="36201" checksum="D96095DF8FB1A778" modified="2017-08-30" version="1">MSSYDGQTKASDLVRELAPHIHGKTILITGASSGLGATYVETVIKSPRPPARIILTVRDQSKGQAQVKKWSYINSDVNLQVISLDLARFKSVREAAKRVNELEFAIDVLVNNAGVMAIPYEKTEDGNEMQFQANHLGHFLFTNLILNKVLESKSGGRIINVSSDGYRLGHVRYSDHDFHNGKSYDKWMAYGQSKTAQLLFSEELARRYGSKGLQAFAVHPGVNMGTSLSRHVNEKEAETFFGSLTAIDQLQGHPQAWAGLKPVSPDQGVATQVLLSFSQDFKDYNGDYFEGCQPLPKDEVYPWALGERESRKCWALSEKLVGERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMS7</accession>
    <name>A0A1Y1UMS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plectin/S10 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_649396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873182.1">
        <property type="nucleotide sequence ID" value="XM_022017982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMS7"/>
    <dbReference type="FunCoup" id="A0A1Y1UMS7">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMS7"/>
    <dbReference type="GeneID" id="33559791"/>
    <dbReference type="InParanoid" id="A0A1Y1UMS7"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="155" mass="17354" checksum="1E4E2CFBA7436AE3" modified="2017-08-30" version="1">MLISKQHRRTIYENLFKEGVLVAPKDYNRATHPNIADVSNLEVIKLMQSLTSKGYVKTQFSWQWYYYSLTDEGLAYLREYLHLPSEIVPQTHMKPARPAGRPGLGGRPGGDGAYRAPRGDREYRRRDDAGGEDKEGPGAGYRPRFGGVGRGAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMV9</accession>
    <name>A0A1Y1UMV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_328804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873254.1">
        <property type="nucleotide sequence ID" value="XM_022012504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMV9"/>
    <dbReference type="GeneID" id="33554312"/>
    <dbReference type="InParanoid" id="A0A1Y1UMV9"/>
    <dbReference type="OrthoDB" id="2575565at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="486" mass="56144" checksum="FFFAAC445F972428" modified="2017-08-30" version="1">MKHHVPYRGAFYTRSRWSTENGVVVYNARWQMYRAYLQLLRLIPDPHLWAYLQPRFRKLCAIERPASKELPPEPDLVGSVAEIEEAYRVWRLAVRNHHEEAIGWTTSLSECKKELNRLRAAVATHPHALLRLIQDAYGQTPSSPLRKELLWAVSESSPPEPQSDEIYELLGEDRTPIPAALEPLAAKREIPNRGVKIRTQRPYHQGKAQNLTAWQRRWSILSPPIYLPKGSGVSCGWEDKGIVVGMRALAGVGNVWLRDRHFRVTDPGRLAKLIPKRLTILDGPHQLPTFQLLSPIMRRIFPIKITKPTLREPPYPQPERHETRNERHLWAGAVPLTSRILRTAYESVWLRLNFTRPVSHDNLDRWVKCSYEEMKAWEAGEDIPASSQPSSGSAPTRPHKFGTITSQEEEALRGSPRRSSGVEDTVYKSAGGDRLLASRIKFQQWQSTRLEEMRRLKEPQNWLFMQTTLLRWMARWEQMQQLSSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNE6</accession>
    <name>A0A1Y1UNE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872877.1">
        <property type="nucleotide sequence ID" value="XM_022017938.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNE6"/>
    <dbReference type="GeneID" id="33559747"/>
    <dbReference type="InParanoid" id="A0A1Y1UNE6"/>
    <dbReference type="OrthoDB" id="2565141at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1771"/>
            <end position="1787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1801" mass="195952" checksum="DA067402D4EA9149" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNI3</accession>
    <name>A0A1Y1UNI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_614360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873405.1">
        <property type="nucleotide sequence ID" value="XM_022014589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNI3"/>
    <dbReference type="FunCoup" id="A0A1Y1UNI3">
        <property type="interactions" value="783"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNI3"/>
    <dbReference type="GeneID" id="33556397"/>
    <dbReference type="InParanoid" id="A0A1Y1UNI3"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="321"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="10">
        <location>
            <begin position="411"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="627" mass="68496" checksum="699A36299DE9AE89" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNR4</accession>
    <name>A0A1Y1UNR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_614520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873444.1">
        <property type="nucleotide sequence ID" value="XM_022014607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNR4"/>
    <dbReference type="GeneID" id="33556415"/>
    <dbReference type="InParanoid" id="A0A1Y1UNR4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="61" mass="6668" checksum="9D859D899887A981" modified="2017-08-30" version="1">MGGDTLFTPGLGIQKSRDASKRLSLKEMSSLKSCRSSLMWLLIPKPCSSSKDLSQCLSCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNW3</accession>
    <name>A0A1Y1UNW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative endoplasmic reticulum vesicle protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_614684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873494.1">
        <property type="nucleotide sequence ID" value="XM_022014629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNW3"/>
    <dbReference type="FunCoup" id="A0A1Y1UNW3">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNW3"/>
    <dbReference type="GeneID" id="33556437"/>
    <dbReference type="InParanoid" id="A0A1Y1UNW3"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012756372" evidence="8">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="24"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="217" mass="24587" checksum="7DCFF0F0698EBA5B" modified="2017-08-30" version="1">MRSWVPSPLVVSVFLLLHLRFAQAVKLELQAERNPKPRCIWNFAAAHSLVIVTANAPFEVGQRIDIDILDGSERGNVYLSKRDIKGETRLAITTHESADVGVCLRNYVQGSSSGKTSRTVELDVDIGADAVDYNAIANQESLSILEVEMRKLEAVTKEIVDEMGYLQRREMRMRDTNESTNERVKNFSILILIGIIALGVWQLIHLRSFFKRKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP99</accession>
    <name>A0A1Y1UP99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_619182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873159.1">
        <property type="nucleotide sequence ID" value="XM_022015135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP99"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP99"/>
    <dbReference type="GeneID" id="33556943"/>
    <dbReference type="InParanoid" id="A0A1Y1UP99"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="35817" checksum="C534C189C498B439" modified="2017-08-30" version="1">MVKTPLVKLEPTGQQMPLVGLGLWQIPKDRCADAVYEAIKAGYRLLDGAGDYGNEREAGQGVQKAIDEGLVKREDLFITSKLWSNFHAEDKVEPACQMSLDLWGLDYFDLYHIHFPIAVKYVDPKVRYPPGWSYDGKGTIILEDAPIYKTWAVMESLVDKKKARNIGISNFRGVLISDLMTYARIPPAVLQVEMHPLLVQEQLIQLCKAYKIHITAYSSFGGPSYGPQPKIGSLFEEEHIVAAGKAHKKTPAQVLLRWSTQRDIAVIPKSNHSERLAENLACCDFDLTEKELKDITALDQDFRFNDPGKVDPRMAIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPH4</accession>
    <name>A0A1Y1UPH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_648549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873716.1">
        <property type="nucleotide sequence ID" value="XM_022017855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPH4"/>
    <dbReference type="GeneID" id="33559664"/>
    <dbReference type="InParanoid" id="A0A1Y1UPH4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013050459" evidence="3">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="134" mass="12590" checksum="2DBEB6828BA647D7" modified="2017-08-30" version="1">MRVLQLALLGAAAVLAQEPSGSPLVDVPDEIANATTTAKDLPPPTEGIVGAGVSGASFTSAADSNSTTSVDPAASTAAEAGTASVVTPSGSDPSGSASASASGAASPMASLDMFTLVGPAMMIVGAVGAGFAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPL7</accession>
    <name>A0A1Y1UPL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_587054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873697.1">
        <property type="nucleotide sequence ID" value="XM_022013749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPL7"/>
    <dbReference type="FunCoup" id="A0A1Y1UPL7">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPL7"/>
    <dbReference type="GeneID" id="33555557"/>
    <dbReference type="InParanoid" id="A0A1Y1UPL7"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF330">
        <property type="entry name" value="SNF1-ACTIVATING KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="132"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="819" mass="90221" checksum="127B69DA84068A49" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPL9</accession>
    <name>A0A1Y1UPL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_575976</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873748.1">
        <property type="nucleotide sequence ID" value="XM_022013163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPL9"/>
    <dbReference type="FunCoup" id="A0A1Y1UPL9">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPL9"/>
    <dbReference type="GeneID" id="33554971"/>
    <dbReference type="InParanoid" id="A0A1Y1UPL9"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012734007" description="GPI mannosyltransferase 1" evidence="14">
        <location>
            <begin position="30"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX39963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="452" mass="50966" checksum="12B2381D44060041" modified="2017-08-30" version="1">MRFSSNLSILTLSLFIHLVLILYAHHVDSHPEQFGGLKYTDVDWRVVIDGARLIVNGGRRRGRSVDDGDPARAQGWIVDALNLKIGDPYARQTFRYTPLLPLVLSPALIHPLLGKAFLTLLSLSIPVVLLSRPSHCRPSKGLVHALWTLNPLVVNITTRGSPEAIIVLLVICTVSALVQNSVTTFKQRENPSSRWEKVAALLYASSISWKIYPVIYAPAIWAHLAKRHRGWFASEIWLFGTWTLFSMLVINLPLWSIWGQPFLDQTFLYHLSRLDHRHNFSPYYYPIYLSISESSMSTPTSSSILSALSAFSQHPLASFVPQMGLATFIGLYLTQKTSLEFAIFLQTVTFIAFNKVCTSQYFTWFIPLLPSVIPHLRLSARRTAVLLSAWVGGQALWLSTAYRLEFLAQSVHLQLWASGLVFFMINVWIIGSLVDSWAEADTRHVEPKQPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPX2</accession>
    <name>A0A1Y1UPX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_258255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873895.1">
        <property type="nucleotide sequence ID" value="XM_022012303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPX2"/>
    <dbReference type="GeneID" id="33554111"/>
    <dbReference type="InParanoid" id="A0A1Y1UPX2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="138" mass="15435" checksum="56830760851EF435" modified="2017-08-30" version="1">MISLLRKAQTVLLRCRAILMPRLVAFPCGPIDVTTRLDAHNHHALSCLRTATPTTRVSALCVSFRYQSCIAHHITTSISTPQHCSPPRSHRVRRKCLTVRQSKRPLFVLDSLVNAQAPTLQSSCPGSCSRMHRRSRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ74</accession>
    <name>A0A1Y1UQ74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-mannosidase A</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_607269</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873995.1">
        <property type="nucleotide sequence ID" value="XM_022014059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ74"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ74"/>
    <dbReference type="GeneID" id="33555867"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ74"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012643672" description="Beta-mannosidase A" evidence="13">
        <location>
            <begin position="19"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="15">
        <location>
            <begin position="30"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="14">
        <location>
            <begin position="974"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="803"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX40210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1067" mass="115656" checksum="B7F5981030C60A72" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ94</accession>
    <name>A0A1Y1UQ94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_616515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873927.1">
        <property type="nucleotide sequence ID" value="XM_022014835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ94"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ94">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ94"/>
    <dbReference type="GeneID" id="33556643"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ94"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="280"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="516" mass="58349" checksum="34C6845FC945FD75" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQN4</accession>
    <name>A0A1Y1UQN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_575852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873579.1">
        <property type="nucleotide sequence ID" value="XM_022013151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQN4"/>
    <dbReference type="FunCoup" id="A0A1Y1UQN4">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQN4"/>
    <dbReference type="GeneID" id="33554959"/>
    <dbReference type="InParanoid" id="A0A1Y1UQN4"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="37517" checksum="38425A10A95BC113" modified="2017-08-30" version="1">MSNETGEIDLDSVIDRLLEVRGNRPGKAVQLQEYEIRYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWADPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDDTLLCSFQILKPAEKKAPKYGGAYGAAGRRKSLLSQRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URB4</accession>
    <name>A0A1Y1URB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_247646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873771.1">
        <property type="nucleotide sequence ID" value="XM_022012277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URB4"/>
    <dbReference type="GeneID" id="33554085"/>
    <dbReference type="InParanoid" id="A0A1Y1URB4"/>
    <dbReference type="OrthoDB" id="3259746at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666033" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="28793" checksum="A4F03DD0C3E89F79" modified="2017-08-30" version="1">MSASHIASLFLLPLVLGSKWHRRDFDSYAGAPVNNITVSADNVVQCSSATVSWTNTNPPVDLAIGIGGYYVGTSWLTTIHVDSDDSTSWTVNVASGDTLIFQVTDSDGAVAYVQNIEVQPSDDDSCLSDQSGPSSAYSSASASATDDGDDSQAASATPSSAESDSAASDSPAASATTTTHAQAQAQAQTQSPSTQSDARPSPTTVISGLGTVPTSTTSRKASAVVTMGSKAATSLSASASASQSGAAQAEQANKTGASLPRFDVPSIMGPLVSVLLVASSAFVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URB7</accession>
    <name>A0A1Y1URB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_261372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873932.1">
        <property type="nucleotide sequence ID" value="XM_022012313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URB7"/>
    <dbReference type="FunCoup" id="A0A1Y1URB7">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URB7"/>
    <dbReference type="GeneID" id="33554121"/>
    <dbReference type="InParanoid" id="A0A1Y1URB7"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="79"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="35614" checksum="B6FE963007AEA654" modified="2017-08-30" version="1">MRISKWTFNVIGHNPKWGETHVRWWPVEVGQRHSCHYTSCLRFMLKYHSLTSRCTQLRRAFSVYKQLNMKVTPVQARSDNWMYLVMDEATNEAAVVDPYNAEKISEQAKEAGVKVTMLLTTHHHDDHSGGNLKFLSLHPGIKAYGGSDKAPGTNHIVKDGDSLKLGQNISIKALHTPCHTQDSICFFLHDKKTDQKGVFTGDTLFLAGCGRFFEGTPEEMHKALSYLGQLPSDTVVYNGHEYTAGSARFGLSVEPDNARLQALAKSATQDSCTTGKSTIGDEKEWNVFMRVDTHEAKKATGESDPVAVVGKLREMKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URG8</accession>
    <name>A0A1Y1URG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_611136</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874211.1">
        <property type="nucleotide sequence ID" value="XM_022014245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URG8"/>
    <dbReference type="STRING" id="4999.A0A1Y1URG8"/>
    <dbReference type="GeneID" id="33556053"/>
    <dbReference type="InParanoid" id="A0A1Y1URG8"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="57"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="242"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX40532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="348" mass="37609" checksum="5C4B2A62D55E34EC" modified="2017-08-30" version="1" fragment="single">MHLGRLSLVPRPAYSIMSSSSAQAASRLSTIHRHLSDGAGSQSGEGRRPAQSNVQHLTVFGAGLMGAGICQIGAQSGLKVVLSDVTDQALENGLNIIRKSLARVGAKTHPDTVEKFTRSIMDNIETTTDAAKAVAHADLVIEAIIESLKVKRDLFGFLDKHASASCIFATNTSSLSVSDIAESCSKDRQANFAGLHFFNPVPAMKLVEIIRTPHTSESTYQTLYSLTKRMGKSPVTCKDTPGFIVNRLLLPYLMEAIRMVERGEATPEDVDLAMELGAGYPMGPFKLLDFVGLDTTSYIASGWREKAAANPGTISSDLVRPIPFLEDMVKQGRLGRKSGKGFYDYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URI5</accession>
    <name>A0A1Y1URI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_611740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874352.1">
        <property type="nucleotide sequence ID" value="XM_022014303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URI5"/>
    <dbReference type="FunCoup" id="A0A1Y1URI5">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URI5"/>
    <dbReference type="GeneID" id="33556111"/>
    <dbReference type="InParanoid" id="A0A1Y1URI5"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="466"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="791"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="942" mass="106889" checksum="772E8F83C28DD777" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URK2</accession>
    <name>A0A1Y1URK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_268346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874022.1">
        <property type="nucleotide sequence ID" value="XM_022012333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URK2"/>
    <dbReference type="GeneID" id="33554141"/>
    <dbReference type="InParanoid" id="A0A1Y1URK2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="150" mass="16835" checksum="44360F0DED14F00C" modified="2017-08-30" version="1">MNKKDGGICVTNYIQDDVQHLPESILRPIRDIINRSEAGQPVHPEDLQNMLYELPPAWLELQSQNFLTYLTDAEGTAYSLGNFKAVVARRGVGGLLLHLIGDPASPKLRRKIATGSFNHVYPWLANVLARNPSLVKKKYRPLFNNPVTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USH2</accession>
    <name>A0A1Y1USH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_658739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874256.1">
        <property type="nucleotide sequence ID" value="XM_022018884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USH2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USH2"/>
    <dbReference type="GeneID" id="33560693"/>
    <dbReference type="InParanoid" id="A0A1Y1USH2"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="34956" checksum="8162EDB1C0E75EFC" modified="2017-08-30" version="1">MLLSLLFAPVASALTLPPILSQGTGCGSPLPSGQTPGSVTNVTIESGGLTRSYLVFVPPTYDPLLPTPLILSYHGGLQTAMDQLELDEFTKPYFNNDSFVIYPQGIDERWQGVPGDHVNDLGFTTDILNSVQSSYCLDLTKIGASGKSDGAGFVNLLACDATLSSRIAAFAPVSGAYYIDKLPCYPDTITIPCNASRSDVPILAFHGGADNIIAYDGGERKDECLPSIPHWIREWAARDGLSETNTTVPFAEDAVIYKYGSTTNCTSGGLVNLVYDSVNGHDWPSTQPNIDNTHLPPYHPVSFNATPMILDFFSQNPLPLWYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USP4</accession>
    <name>A0A1Y1USP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_34553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874710.1">
        <property type="nucleotide sequence ID" value="XM_022012537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USP4"/>
    <dbReference type="GeneID" id="33554345"/>
    <dbReference type="InParanoid" id="A0A1Y1USP4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="293" mass="32919" checksum="4E6FDAE8330F9EE3" modified="2017-08-30" version="1">MNGVKILSVFPHHDHCSLAAGGNLPCRAIWDGSKGFLWKAEEDAAIGRPSLSRSRELESGQSVGSHKSWMFWVERRLLSTEWFVFDHYFAVWEGRACRKRSGWVSRSTTRLVDPSGRDIRIGLARRTPPRAASGDQSACPARKLFLESSHTLAHNHSAPLYRRLVVSAFPRDRRRQQSRQTSIPPLSPSPSPWIPEPICASQVSTRYSVLSSVSHVLEDQLYRFFSRTVHPSPLARRIRLLLSVGEDPTRVESCARAFTPWQVVRSPVICPSELVLVGGHVGHSCERCEGCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USR3</accession>
    <name>A0A1Y1USR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874145.1">
        <property type="nucleotide sequence ID" value="XM_022017648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USR3"/>
    <dbReference type="GeneID" id="33559457"/>
    <dbReference type="InParanoid" id="A0A1Y1USR3"/>
    <dbReference type="OrthoDB" id="2595549at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="586" mass="63276" checksum="E287504D0A0E0D31" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USU8</accession>
    <name>A0A1Y1USU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein MSH2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein Msh2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">MutS protein homolog 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_613143</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874769.1">
        <property type="nucleotide sequence ID" value="XM_022014473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USU8"/>
    <dbReference type="FunCoup" id="A0A1Y1USU8">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USU8"/>
    <dbReference type="GeneID" id="33556281"/>
    <dbReference type="InParanoid" id="A0A1Y1USU8"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051053">
        <property type="term" value="P:negative regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000925">
        <property type="entry name" value="DNA mismatch repair protein MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX41090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="961" mass="107711" checksum="89B4F3C90631496F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USZ6</accession>
    <name>A0A1Y1USZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874235.1">
        <property type="nucleotide sequence ID" value="XM_022017667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USZ6"/>
    <dbReference type="GeneID" id="33559476"/>
    <dbReference type="InParanoid" id="A0A1Y1USZ6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="300" mass="32870" checksum="D89526F6308B0757" modified="2017-08-30" version="1">MRGGPRSSKISRGVGSKPTDLVDGRERMTDDHLPCHDERVTPPIYPGLSKAYNARHEDSLYNSWANAFHSSDAIHDDTDLNDELRPTPNLYHISDIPLTTCNDYHEAAHPRSHSQTLHNHMYNNAATPVLLHGPVISSSTLSIVSPLSPGSPLSSSLELWKTYTRGLSIAERLESSSDLSMAGRADSAFDPIRPWTDGVPSDLAESDPRDDPVQRFPRYEGEQSRPLSAQLDPSPSPAQSARPHSSPSQRSARKLRKAMIVEGDWDMLREGVWAPAISLPNVAASPMFPDIAVACKSGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT40</accession>
    <name>A0A1Y1UT40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutaminase</fullName>
                <ecNumber evidence="9">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_596848</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874868.1">
        <property type="nucleotide sequence ID" value="XM_022013869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT40"/>
    <dbReference type="FunCoup" id="A0A1Y1UT40">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT40"/>
    <dbReference type="GeneID" id="33555677"/>
    <dbReference type="InParanoid" id="A0A1Y1UT40"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 12" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="434"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="520"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="546"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="11">
        <location>
            <begin position="569"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX41189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="600" mass="64659" checksum="D606C10A95023543" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTI4</accession>
    <name>A0A1Y1UTI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_575050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874606.1">
        <property type="nucleotide sequence ID" value="XM_022013102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTI4"/>
    <dbReference type="FunCoup" id="A0A1Y1UTI4">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTI4"/>
    <dbReference type="GeneID" id="33554910"/>
    <dbReference type="InParanoid" id="A0A1Y1UTI4"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="205" mass="22429" checksum="94880AE988EAE0BB" modified="2017-08-30" version="1">MLAVYTGLCSLCSRPSSTLGSNLQALLDASGTPRLPNAQVTFVLSSRSNAYGLTRAQNQSIPTSVCALKTYLNRHPGATREDYDAEVARLVVESKPDLVVLAGWMHILSDRFLDIVNVPCINLHPALPGAFDGAQAIERAYEAFKRGDIHHTGVMVHRVIKEVDRGEPLVVRQVDIGPGDSLEDLETRIHKVEHEIIVEAARLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUC9</accession>
    <name>A0A1Y1UUC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874735.1">
        <property type="nucleotide sequence ID" value="XM_022014467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUC9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUC9"/>
    <dbReference type="GeneID" id="33556275"/>
    <dbReference type="InParanoid" id="A0A1Y1UUC9"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118289" checksum="2BCF200FEA1CA9E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5C5</accession>
    <name>A0A1Y1U5C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_654306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000034">
        <property type="protein sequence ID" value="ORX33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867600.1">
        <property type="nucleotide sequence ID" value="XM_022018786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5C5"/>
    <dbReference type="GeneID" id="33560595"/>
    <dbReference type="InParanoid" id="A0A1Y1U5C5"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
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        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="3">
        <location>
            <begin position="245"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="409" mass="46002" checksum="821B2CEC347F4D3B" modified="2017-08-30" version="1">MDITFESFAKLIYRLSHPPQARSRENRTFTPADIFTSWLNHLDRPLPPGSGKHVLRILFPHEGCRRRYGMKEMKLACELERILRIKGLSRWDSAGSPGGGSGCLGLEVQRVCKERTTSRVSSLTLAEIDLRLDQLASYSPFSQLEVPPCDPPSQTDILSHLFRDSNLSSYASGLLIQIILQDIRPFLDPLPKLALRNATSLLRMKSTHGPPQLDLLSAMRAWDPRMADMFVDGKGDLDWYSEAQAIFRAQLGLLNALALLGFAHARLKPQWARRLERTNLMNPDFIADSLHHFYLLHSSLEAGRPLPVNTSILERLVYHSQSSDGTRTNAWKGDSEPNFEQREEDQALAALGQKLTWNLCHDEQMSIFAATTVAMTYVASGLEELTREIADLVGETSLAGLDRARERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U659</accession>
    <name>A0A1Y1U659_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867835.1">
        <property type="nucleotide sequence ID" value="XM_022018748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U659"/>
    <dbReference type="GeneID" id="33560557"/>
    <dbReference type="InParanoid" id="A0A1Y1U659"/>
    <dbReference type="OrthoDB" id="2596916at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="354"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="389" mass="41573" checksum="D973C514046557B7" modified="2017-08-30" version="1">MSSSISSTSSLSGLASSSSSPIAKRMMAARTSHSMDISNSTGGPSRPRPPRTCLSSPGGCIVGTGGGGGGGSSSRRPIPRSVSASAKSPSRLPNTDTMSYFPPFESMGSTSDSEEGDHDHEANLTAAPQVDPRAHGKGRSLSSLAGIMSFLSPGSTTSHSPDSAAVHALSQRFTNKRRVLEPMTSAEPPVSRLPTSQHKRRFGSEVEVENLLSRRRDRVVSNVVKMDELAVESLVGDRGMLTLPSHPSWRYPIPSPPVAAVVSSGEISLDAFAKPIENPIKPTSRRSSSASAKSHHSSDCDQVEDDLSPTISTSVQSLSNPETPKEKSVPVKITFISPDDRASPKGGSLKEEKWWKERHDDWDLKVKRGTTIDGRRRQSWGVQQVQQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6W5</accession>
    <name>A0A1Y1U6W5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_198560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868070.1">
        <property type="nucleotide sequence ID" value="XM_022012158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6W5"/>
    <dbReference type="FunCoup" id="A0A1Y1U6W5">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6W5"/>
    <dbReference type="GeneID" id="33553966"/>
    <dbReference type="InParanoid" id="A0A1Y1U6W5"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="375"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="648"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="882" mass="95794" checksum="B557A75E7D59EDF2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Z1</accession>
    <name>A0A1Y1U6Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_638679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868108.1">
        <property type="nucleotide sequence ID" value="XM_022017143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Z1"/>
    <dbReference type="FunCoup" id="A0A1Y1U6Z1">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6Z1"/>
    <dbReference type="GeneID" id="33558952"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Z1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="28517" checksum="3DE3AEA20D69C310" modified="2017-08-30" version="1">MSRSSYDRYLTVFSPEGRLYQVEYAIKAISGAGITAVAVRGKDTVAIITQRKVPDKLLDPDTITHIFQITPTIGCVMTGLIADARAQVQRTRSEAATFRYKFGYEITPAALAKRMANINQVYTQRAGMRPLGISMILIGVDEELGPQIFKLDPAGYFTGYKATASGQKQTEASNFLEKRWKGIEADKTVLDRGAVLEAAIECLSTVCATDFKASEIEIGIASISPDEPHPEGKAGAGGIGKFRQMSEEERGEWLVRVGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U726</accession>
    <name>A0A1Y1U726_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868101.1">
        <property type="nucleotide sequence ID" value="XM_022018715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U726"/>
    <dbReference type="GeneID" id="33560524"/>
    <dbReference type="InParanoid" id="A0A1Y1U726"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="160" mass="17291" checksum="8B977ACE9B7BC89F" modified="2017-08-30" version="1">MTVLGASAAIMGSRESEIRMLPSCSHLEPVQTLPDLLAQSTGDKRSRTQSHYQGIPMSVIVSDPTLDEGGPRSHSKSPVRQESSGTLQSACMGLVSRPMITPKRLRLSRCFQQLRLVQADRSDPPTGKSSGAGGVLLDEGTVEDHNEESEDDEEDVTFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7A7</accession>
    <name>A0A1Y1U7A7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_653608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868198.1">
        <property type="nucleotide sequence ID" value="XM_022018679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7A7"/>
    <dbReference type="GeneID" id="33560488"/>
    <dbReference type="InParanoid" id="A0A1Y1U7A7"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="72" mass="8229" checksum="3A103202AB1156C4" modified="2017-08-30" version="1">MPSPWTPEDRARLFAWVEQNGAGNWTQAATQIPGRSAKQCRDQWVQILAPMIKRLCNLPSVPKSKKNVKMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7C9</accession>
    <name>A0A1Y1U7C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_654156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867779.1">
        <property type="nucleotide sequence ID" value="XM_022018757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7C9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7C9"/>
    <dbReference type="GeneID" id="33560566"/>
    <dbReference type="InParanoid" id="A0A1Y1U7C9"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34798" checksum="CE0F096F3888922A" modified="2017-08-30" version="1">MSSIELDAEAISALHIPAVGGKITEKLRDGLAKVQRVQTRHRVNIVDHWGGSQFFNGAKVLEIGCGQGDMSTVIATAVGSAGAGQITAWDPAPGSYGAPLTMSEAHETLTSNKELDNLKFVIDSPIDTVLTSEASYTHAVLVHSLYYFESEAVLLETFRRLATNTPAIKYLCLAEYALRADIVEQVPHLLSVLAQAAVHALHSDDKATNKSPSSNVRTVVGPGRIIELATEAGWKLCTKDDGSSHEATFTPDADLQDGSWEAQTVGDKSWELDIRGEGNQTRKSAASALEAFQNSTATSLTSLRATSRKTATMPVWCAVFERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7E0</accession>
    <name>A0A1Y1U7E0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAM signaling pathway protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_654131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867752.1">
        <property type="nucleotide sequence ID" value="XM_022018753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7E0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7E0"/>
    <dbReference type="GeneID" id="33560562"/>
    <dbReference type="InParanoid" id="A0A1Y1U7E0"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="225"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="839"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1237"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1280" mass="140040" checksum="247A31823E9818F4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7N3</accession>
    <name>A0A1Y1U7N3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_193777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868328.1">
        <property type="nucleotide sequence ID" value="XM_022012140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7N3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7N3"/>
    <dbReference type="GeneID" id="33553948"/>
    <dbReference type="InParanoid" id="A0A1Y1U7N3"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="884"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117650" checksum="443999E7E618CBF7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U801</accession>
    <name>A0A1Y1U801_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867956.1">
        <property type="nucleotide sequence ID" value="XM_022013710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U801"/>
    <dbReference type="STRING" id="4999.A0A1Y1U801"/>
    <dbReference type="GeneID" id="33555518"/>
    <dbReference type="InParanoid" id="A0A1Y1U801"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="147" mass="16120" checksum="4D03E2656F4052CA" modified="2017-08-30" version="1">MPRLLTPYLRPAWSMPCEPSSSASCLSPSNSNMDMPVPVSRSNAIASKGWMSLVPGLESLLELIPPILLAVPKKKVSHRKKMQKLAGKGLVNKTNFKTCPACGNIVLMHNLCPNCFFSINKGWKMERRGESFPTEFTSEAGVKNASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U874</accession>
    <name>A0A1Y1U874_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_172355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868491.1">
        <property type="nucleotide sequence ID" value="XM_022012092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U874"/>
    <dbReference type="GeneID" id="33553900"/>
    <dbReference type="InParanoid" id="A0A1Y1U874"/>
    <dbReference type="OrthoDB" id="10668225at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="298" mass="32616" checksum="CA373601336886D5" modified="2017-08-30" version="1">MDSVPFLRRLSMDSRRPDSSVIFPRYGEGTRPNSMALTASRPASIAVASEMSEEDLRAVFRQNLHSPNLQFASRVPTPESTPRKNHKLIKTTFSNAILCRVCHANVKKSGLLCQTCGMICHTTCATKAGMTCDVKLQLVLLARQEEMLSMAGLETTTSFHSPQSTQTRGQRGASSPAPMSPAEDADHDNETIGAGKLFAGLRARRESAKGPSRIRRLSRRSSKAVPDDLTAAECFSAEPSEHRRDNATRFQTEMRHLHHHEGVASSAATKSQNNLQIDVLPASSRELEPSGKSDCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U887</accession>
    <name>A0A1Y1U887_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868529.1">
        <property type="nucleotide sequence ID" value="XM_022016984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U887"/>
    <dbReference type="GeneID" id="33558793"/>
    <dbReference type="InParanoid" id="A0A1Y1U887"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="193" mass="21297" checksum="7DFE7B02AC189915" modified="2017-08-30" version="1">MLSDSDSDEEDMERLYDYYKTYNEKITHAFHEQLDPIIEDELVGLPSVYLTPPTPEMLPVSPDDDSISQGQELLETPPSLTLEGTWRDASDSPSSSILPSPNPQSRIGLGLEMEESTAPSISLSKTDWADMDDDFPMVFPSSEYAPPTAEPHSALQPGLELELDRSSPTSVPASTICWADMDDDVPMVFPDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8I5</accession>
    <name>A0A1Y1U8I5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_653128</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868613.1">
        <property type="nucleotide sequence ID" value="XM_022018613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8I5"/>
    <dbReference type="FunCoup" id="A0A1Y1U8I5">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8I5"/>
    <dbReference type="GeneID" id="33560422"/>
    <dbReference type="InParanoid" id="A0A1Y1U8I5"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="122"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="379"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="509"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="685" mass="76769" checksum="A9727FDBA4F643BA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8N3</accession>
    <name>A0A1Y1U8N3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_684183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867802.1">
        <property type="nucleotide sequence ID" value="XM_022019208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8N3"/>
    <dbReference type="GeneID" id="33561017"/>
    <dbReference type="InParanoid" id="A0A1Y1U8N3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22183" checksum="9C0D75969147D551" modified="2017-08-30" version="1">MPAEPKTPTKTPRTQPYPTPDSRSKSSIPWGGVKVDRATPTRVIVIESEDEGDGEQSNGLAENDNDEGTETWSPPQTPSSSPESSGGSVFEIDSEEEVKPSMEPESEDDVKPKIKNPRAGAKRGAANQAKVKKEPSGRPRGSGGPGGGSKGTPWTAEQDWALFQMRYPKAPVKWSDVAQAVGRDAKSCSNRDALFAKKLPGLIKGLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Q1</accession>
    <name>A0A1Y1U8Q1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_206499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868166.1">
        <property type="nucleotide sequence ID" value="XM_022012180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Q1"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Q1">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Q1"/>
    <dbReference type="GeneID" id="33553988"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Q1"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="9">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="364"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="445" mass="46916" checksum="4B5AA1DF7A8122C6" modified="2017-08-30" version="1">MADTTQPNEADTTHGSTEVPAADTADLQSQAEKLIAEGKKAIALKQWEEGVAKYADALDLRRQLVGEFDPSMAPLLLSYGKALYELAFSQAGVMGKEEVEKQAGGETIRAEEGGSGNFVFSADPVSDDDEVEGDGQGNGVEESGPSATRPTEVESEGDAEVGINGAGEEAEEVDEPEDDYNAAWEVLDVARTIYSKMVQGREGSDAREDRLNLAECYLALGDVSCETENFTQAVQDYTSALEIKSALLPSSARSLASVHYQLATVLEFTPNRRADALKHVESAVTGFKARLAELASDSEQSDEVKKLSEKEKEKEVEDVKALIGDLEVKIEELKAAPPAEDLVSESINHLLGSDALGSALGSMLNGSSSGSGGPSGSSVGDAPVNDLTSMVKRKPKKAPVPANGSMNKVEAEAEGVSENGTIAGVKRSAESDAQNGDADKKVKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8W0</accession>
    <name>A0A1Y1U8W0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_637892</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868272.1">
        <property type="nucleotide sequence ID" value="XM_022017063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8W0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8W0"/>
    <dbReference type="GeneID" id="33558872"/>
    <dbReference type="InParanoid" id="A0A1Y1U8W0"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011824475" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="804" mass="88153" checksum="E0BCF0E94E933BEF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9F2</accession>
    <name>A0A1Y1U9F2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_124059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868884.1">
        <property type="nucleotide sequence ID" value="XM_022011970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9F2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9F2"/>
    <dbReference type="GeneID" id="33553778"/>
    <dbReference type="InParanoid" id="A0A1Y1U9F2"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="349" mass="39175" checksum="B19331989E2AE0D0" modified="2017-08-30" version="1">MPFDGSCVGFLGYSILERYVKYTEGFIPIPGMGIEPKPYLLWGSRLTRIYRVSIWMTVFAFSAMSAVHLEEILYWVYMIRACRKNGSAHWFQTIWFKIWVAGSVICTGIFFGCTGINPDFAKIETNLYLSASLVSLVLVVGSGWTSYLFPQFIAEARRLGANQDVLGRLLYVNVLNNLRTTFRVAYVVILLTLSVDGLTEAQKINNNRFALDVLMIAGYFSIFAAETISLWVSCLLPSSPLIVLGPPTPQECPGVEAGPVASLRSSGGTSTRQCHRQDRGRRRPNGKCMGRSGRSTQLGARPSVRVQSRERHVYQGSRPSLRTASTQGTWCSEWKRYNLSTRRPLLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9L4</accession>
    <name>A0A1Y1U9L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_643262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868963.1">
        <property type="nucleotide sequence ID" value="XM_022017533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9L4"/>
    <dbReference type="FunCoup" id="A0A1Y1U9L4">
        <property type="interactions" value="923"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9L4"/>
    <dbReference type="GeneID" id="33559342"/>
    <dbReference type="InParanoid" id="A0A1Y1U9L4"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="192"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="471"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="546" mass="60612" checksum="FCF84BCC0FF6A38E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9P7</accession>
    <name>A0A1Y1U9P7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_634776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868984.1">
        <property type="nucleotide sequence ID" value="XM_022016757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9P7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9P7"/>
    <dbReference type="GeneID" id="33558566"/>
    <dbReference type="InParanoid" id="A0A1Y1U9P7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="239" mass="26679" checksum="FE58B6EA63802181" modified="2017-08-30" version="1">MVKRGIDVGSGSGIWALEMAKEFPEVQWTGLDLFAIERRPSQPSNVEYVKGNVLTGLDFPDGHFDIVHARHLITAVQNWRPVIDELVRITKPGGLIISVEICFPITVYNGTEEDTLKLAPGFAACHNVFMAAFKARGTDLLPGYTVATLLREHASVKETGQLESIFPFTPCTDDPNAIEAGRIMKENVLSMPESTRQIFMSKPGVTEEQFQQIKAGFTNDIERGIPLAAKLWHNWAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA38</accession>
    <name>A0A1Y1UA38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rec8 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_635604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868640.1">
        <property type="nucleotide sequence ID" value="XM_022016828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA38"/>
    <dbReference type="FunCoup" id="A0A1Y1UA38">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA38"/>
    <dbReference type="GeneID" id="33558637"/>
    <dbReference type="InParanoid" id="A0A1Y1UA38"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="545"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="609" mass="66858" checksum="95D1987B356C1B01" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAD5</accession>
    <name>A0A1Y1UAD5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_652694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869188.1">
        <property type="nucleotide sequence ID" value="XM_022018536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAD5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAD5"/>
    <dbReference type="GeneID" id="33560345"/>
    <dbReference type="InParanoid" id="A0A1Y1UAD5"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="358" mass="39293" checksum="8851FDDF4E89C1B7" modified="2017-08-30" version="1">MQQEKDVEGSEKARQDGNTSFKKGKWSEAIGHYTNAILKNPTDPVGYTNRAAAYLKLDKYEDANRDCTSAIEIQPENLKALYRRSLALKSLGRLDEALRDISLVCKLDRGNAVAKEERKEIRELVEALEKKSQQFKPPQKTPPISPESRPIAASIEEIVEETSQPTVPSHESSQTTPIQSIPKPSFSDLKRSRAAKPAFTTAKLPAHTPDASKPPITTPLHHDILPIASSPAPRLFVPPADPHSTSPGSGLTLLRHLSPPQLGWTAIQHYPAQNVPIILGPLLEPDTLAQLFSALKHGLDGSSDSAVALDEARARILIVMKGLLDLPRWRVNASMLSRSERELGRQVWAQAGGQGQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ7</accession>
    <name>A0A1Y1UAJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_572648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869279.1">
        <property type="nucleotide sequence ID" value="XM_022013053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ7"/>
    <dbReference type="FunCoup" id="A0A1Y1UAJ7">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAJ7"/>
    <dbReference type="GeneID" id="33554861"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ7"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="343" mass="36627" checksum="6633272FC7623D5C" modified="2017-08-30" version="1" fragment="single">MPLESCMLVLDNSEYMRNGDYPPTRFRAQAEAVSTIFNSKTESNPESAVGLMTMAGKAPSLLVTPTNDLGKLLSALNKSTIGGLSDFQTAVQIAQLALKHRENKNQKQRIVVFVGSPLEDSQESLVKLGKRLRKNNVLIDVVTVGEEGMENDEKIAAMVEAAGGNDHLVSVPPGPGLLSDIVRQSPILYDADRPGGDAMDGDDFDPSMDPELAMALRMSLQEAEQNAQRQAQAQAGPSTSSAPEPVPQAAGAPAGASSSAPIQVDSTPASRPTTGTNPDAIMEEDEEDEDEMLRRAMALSRGEDVMMGEGGDDDEEDEDEEAAIARAIAMSLEQQEGQQDKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB15</accession>
    <name>A0A1Y1UB15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_637334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868553.1">
        <property type="nucleotide sequence ID" value="XM_022016992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB15"/>
    <dbReference type="GeneID" id="33558801"/>
    <dbReference type="InParanoid" id="A0A1Y1UB15"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="727"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="800" mass="89311" checksum="F76FCE429F412221" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBK1</accession>
    <name>A0A1Y1UBK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_635405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869108.1">
        <property type="nucleotide sequence ID" value="XM_022016809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBK1"/>
    <dbReference type="GeneID" id="33558618"/>
    <dbReference type="InParanoid" id="A0A1Y1UBK1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="577" mass="64475" checksum="6DBBE3CDDC63D6E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCI9</accession>
    <name>A0A1Y1UCI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GPI transamidase subunit PIG-U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_77616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869932.1">
        <property type="nucleotide sequence ID" value="XM_022019245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCI9"/>
    <dbReference type="FunCoup" id="A0A1Y1UCI9">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCI9"/>
    <dbReference type="GeneID" id="33561054"/>
    <dbReference type="InParanoid" id="A0A1Y1UCI9"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="406" mass="44569" checksum="86512668C862B7FF" modified="2017-08-30" version="1">MTSRTLISDVSQRHKLVLVVATGILLRVYLLFGTSAHILLRDRPELSTPQTSHRSLKEGVFQRINLPLTPGSANSELYVAIFSHLIPFNHWSWALTWIAADLGTSIALLSFANSLSTGASLNDPAIVASYLLNPYSIAACIAQATTSLDNLCIVFIAALAVRGHRLASMITLGLTAHVSPYVILLLPSFVLIAKTRRPGSWLSSVLVSCAAYAGASYALRIPLWTRLLDLQVNLKDLTPNSGMWWYFFTEIFDHFRTFFLCVFQLHILAYVLPLQIRLKSDPSLVVLVMLGTIATWRSYPSLGDLGLGMSLLSCFPNVVSDLRHPLFTASVYLYTAILLPLLHALWLLTGTGNANFFYAATMVHGLNSSLAIVDIVGAVFRSSLRKAAGPVRPGRERYIVQLTGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCQ2</accession>
    <name>A0A1Y1UCQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_87597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869476.1">
        <property type="nucleotide sequence ID" value="XM_022019271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCQ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCQ2"/>
    <dbReference type="GeneID" id="33561080"/>
    <dbReference type="InParanoid" id="A0A1Y1UCQ2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="171" mass="19093" checksum="1C715CF41DD92278" modified="2017-08-30" version="1">MPHRMFFEASYILLHRPIVSPHDIATASGPAAVCLQHSSEATNLAVRFTRTFGEYLRYLPRYCWFVAASFDIVMLDSKIQSVQRLALDRLSLWLNTMTNNLLRAPSMRRSVQHISSRIYEVLARNPYLAQSPTGISILAHLRGQRGMGGGPSPLGAAANEGMGFFELLQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD34</accession>
    <name>A0A1Y1UD34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_629669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870090.1">
        <property type="nucleotide sequence ID" value="XM_022016240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD34"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD34"/>
    <dbReference type="GeneID" id="33558049"/>
    <dbReference type="InParanoid" id="A0A1Y1UD34"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="457" mass="51799" checksum="10BF632E5E979861" modified="2017-08-30" version="1">MSNTIAQWAAHASQSFSSAQGPAVVASIPLNDRHSAYHTLVQALSSVSDTAISTTSVLSYVSVRNETKDIFASFLVAILKYLQVFSNSSPDAERAIEAFRRLNAVQIEANRLYGMTGSDGGFIHAFMNPFMVMLCRHLIRTAKTAAAVSPHPPRSNLSSRSIRDTTRQTIEKTFQISSSVVSEGDWAASTSHQYLVGDIVWPLANMLWRIYAERKLHTQASGLAKTLGSLTPPENKRVSSRAMSLHQTDLCESYYWRGKLGVVLLDMRNAKFWLDKAWQMCPSDCHQQQRAILIRLLPVNLLLGYSPTMTLLQRYKLGDFMPLLRAFQSGNVVAFRRELLNCRDWYRHRSIWLILYERGEILVWRNLFRRALRLYYNLNPESPKNRCPTWVFLAASQRAFEGSNEVEVGNLAIEDIICVMSSLIDQVSRMSCMAAYFADIPAHRVSSWDIYLIPMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDB4</accession>
    <name>A0A1Y1UDB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_59223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bleomycin resistance protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869701.1">
        <property type="nucleotide sequence ID" value="XM_022013813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDB4"/>
    <dbReference type="GeneID" id="33555621"/>
    <dbReference type="InParanoid" id="A0A1Y1UDB4"/>
    <dbReference type="OrthoDB" id="4235865at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08349">
        <property type="entry name" value="BLMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000335">
        <property type="entry name" value="Bleomycin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19581">
        <property type="entry name" value="Glyoxalase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="4">
        <location>
            <begin position="31"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="154" mass="17735" checksum="EB651A56C553BE05" modified="2017-08-30" version="1">MITTTWIRCEKFTLNASTLIPLVPHSTMSIHFESVIPVLRIFDEVKAAEFYQGFLGFKCDWTHRFEEGFPLYQQVSRDGLVLHLSEHHGDGGPAIHVRVMMTGVDHFHKEVSSKQYKYLRPGCDKSEVTGMLEMKVTDPFGNRLTFCQREEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDC9</accession>
    <name>A0A1Y1UDC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_518837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870151.1">
        <property type="nucleotide sequence ID" value="XM_022012981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDC9"/>
    <dbReference type="GeneID" id="33554789"/>
    <dbReference type="InParanoid" id="A0A1Y1UDC9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="407" mass="45137" checksum="0127C872D45DDAEC" modified="2017-08-30" version="1">MSSIAESSETPVKLKRITACLHCRRQKLKCDVGKSKPCTRCKDEDVECVVRPRANAAILTDDLRWQQSVETRLQSVQKELEQLRHLSSRQSHHALPTPGTQTDGSNPIGTARSEPMQAIPPLPPHLLGLRNILAESLAALEFASHEASAEEAALLWEDFYSSLAIFHGFIAGPMITAPSPLLLTAIAAASSARSSESSTLSRHPIWVGLFERALASFLAGTRTRSWDDPVALCIARTWFWTADCSTTGLIYGAYLSTLSPSSADLRSRRVWDFILITAASHSVLHLDTIIIPERPPSLVPMREYPHVLFGALTELFDIIGELPRVMSGADGIIMSLLRPRETRHWSYAQHSILKTSITDVQRWGTKWITAIRGTSDDRLPGGRSRQFLLDLVAVYYQAAMLILYGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDF6</accession>
    <name>A0A1Y1UDF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTD kinase subunit gamma CTK3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_61499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869741.1">
        <property type="nucleotide sequence ID" value="XM_022014670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDF6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDF6"/>
    <dbReference type="GeneID" id="33556478"/>
    <dbReference type="InParanoid" id="A0A1Y1UDF6"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="30230" checksum="61E0CD9815AC2C79" modified="2017-08-30" version="1">MSFDAFEARLQFLQLLRKLNASSQSIQKVVSFAVKNGARCGDDLWECILDESAKGSLNTRINILYFLDSLLDTSLALGPPDAPYASLIARNLGKIVSRVVPETREGVLNAKAARQILESWRTRRLLESGTIDEAVQMLETRKPTTTEITKRSRDDAFSRSDILRRMEEDRERHKRLRERIWILPIPPLAKPPSASPSASSPFTPASPSTSQPADLVKAVVEQKMLPPPKPDRRVESALEVEFEQTWDGVSDLDEGDFDAMRGDAAILAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDG0</accession>
    <name>A0A1Y1UDG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870209.1">
        <property type="nucleotide sequence ID" value="XM_022018421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDG0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDG0"/>
    <dbReference type="GeneID" id="33560230"/>
    <dbReference type="InParanoid" id="A0A1Y1UDG0"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="2">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="3">
        <location>
            <begin position="407"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="811" mass="88234" checksum="47006A79CA0FA390" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDH1</accession>
    <name>A0A1Y1UDH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870210.1">
        <property type="nucleotide sequence ID" value="XM_022016293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDH1"/>
    <dbReference type="GeneID" id="33558102"/>
    <dbReference type="InParanoid" id="A0A1Y1UDH1"/>
    <dbReference type="OrthoDB" id="2828670at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012010937" evidence="1">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="153" mass="15968" checksum="AD3C4206F889A683" modified="2017-08-30" version="1">MFAAIGLLSLLGSALAGPISIGKRDDVHCGTTSDATLSDCQALVTPEIWNQVFNTGNVCHFTNPLANIYDGTALNLACHENCCVYYTNNQANPGSSLYQSSETLRQAAAGLLGCGDTSANKINGLDNLDGYAICISDGNGCGDCFDDADWAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDI4</accession>
    <name>A0A1Y1UDI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="13">dUTPase</shortName>
            <ecNumber evidence="5 13">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_630091</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5 13"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870212.1">
        <property type="nucleotide sequence ID" value="XM_022016295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDI4"/>
    <dbReference type="FunCoup" id="A0A1Y1UDI4">
        <property type="interactions" value="960"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDI4"/>
    <dbReference type="GeneID" id="33558104"/>
    <dbReference type="InParanoid" id="A0A1Y1UDI4"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000007">
        <property type="entry name" value="dUTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="15">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="182" mass="19035" checksum="EBCCE672A52C8B43" modified="2017-08-30" version="1">MSDASQPSVDYAVDLLIQLRSPEAKMPTAGSDLAAGIDLYAAESKVVPARGKALIDLGMSLAIPPGHYGRVAPRSGLASKHSIQTGAGVIDADYRGPLMVLLFNHSDEDFQVNPGDRIAQLILERISVPRLRQVESLEETARGSGGFGSTGGFGPAAKKQKLENGEGAVLPEPTEAIIEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDK7</accession>
    <name>A0A1Y1UDK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_523395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870221.1">
        <property type="nucleotide sequence ID" value="XM_022012993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDK7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDK7"/>
    <dbReference type="GeneID" id="33554801"/>
    <dbReference type="InParanoid" id="A0A1Y1UDK7"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="200"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="616"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="669" mass="73579" checksum="6479FF880D0EDE14" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDM9</accession>
    <name>A0A1Y1UDM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869790.1">
        <property type="nucleotide sequence ID" value="XM_022016382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDM9"/>
    <dbReference type="GeneID" id="33558191"/>
    <dbReference type="InParanoid" id="A0A1Y1UDM9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="200" mass="23224" checksum="C5887D3602936E00" modified="2017-08-30" version="1">MTYLALLSIYNAQPRHITLSCLVKQIEAHLKIIHLRSQSDEWQTIKMNREREMNGGDAIERITDAVVETHLARARTLLDDAQTEAFMVFGVCGGQMIKSLNRLERRLDKRTAWYAEYNRDSEHGSNGWRQDDEEDKSEDDAVDAIKAALANSTMDRTLHRTPYEDESSKENRHGRRRVSFTNKASKHRKDNGLHEREENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDU4</accession>
    <name>A0A1Y1UDU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_581341</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870288.1">
        <property type="nucleotide sequence ID" value="XM_022013494.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDU4"/>
    <dbReference type="GeneID" id="33555302"/>
    <dbReference type="InParanoid" id="A0A1Y1UDU4"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1138"/>
            <end position="1161"/>
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            <begin position="1245"/>
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            <begin position="74"/>
            <end position="127"/>
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        <ligand>
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        <location>
            <position position="533"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <ligand>
            <name>ATP</name>
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        <location>
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        <ligand>
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        <ligand>
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            <dbReference type="Pfam" id="PF16209"/>
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            <dbReference type="Pfam" id="PF16212"/>
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            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
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    <sequence length="1510" mass="169220" checksum="1978B6A16B16E267" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDV7</accession>
    <name>A0A1Y1UDV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_627984</name>
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    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="189"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX36231.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
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    </evidence>
    <sequence length="232" mass="24606" checksum="80036260806B07BD" modified="2017-08-30" version="1">MSEPADATATSVESSSAAAPSASVGSSAEGVQKLRLDTETRGHTAAERSDLCSPSPSASASASESDDNDDISKSVSRLERELDALRTPSGQKSLSDRLRFDDLPPISTSPPPSEADTEDSQAPEPASMTENEELSPSRSHNSDREWLQNKVDKEEAEGSTGLGPFIFVQGGENKRNTLLVPATQKARRKGVDAEEGQAKEVASTDASLVEDGEPSGSRSKLPARTFEHPPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE56</accession>
    <name>A0A1Y1UE56_9TREE</name>
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        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="ORF">BD324DRAFT_628291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870424.1">
        <property type="nucleotide sequence ID" value="XM_022016111.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UE56"/>
    <dbReference type="GeneID" id="33557920"/>
    <dbReference type="InParanoid" id="A0A1Y1UE56"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="512" mass="57837" checksum="751AB513DE653ADA" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEA3</accession>
    <name>A0A1Y1UEA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SEN1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_645965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870474.1">
        <property type="nucleotide sequence ID" value="XM_022017616.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEA3"/>
    <dbReference type="GeneID" id="33559425"/>
    <dbReference type="InParanoid" id="A0A1Y1UEA3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="7">
        <location>
            <begin position="89"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="10">
        <location>
            <begin position="1326"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="8">
        <location>
            <begin position="1466"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="9">
        <location>
            <begin position="1750"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1980"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1206"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2066"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="2106"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2135"/>
            <end position="2144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2144" mass="237216" checksum="57C568FBA40E8808" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEI3</accession>
    <name>A0A1Y1UEI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_494790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870500.1">
        <property type="nucleotide sequence ID" value="XM_022012938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEI3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEI3"/>
    <dbReference type="GeneID" id="33554746"/>
    <dbReference type="InParanoid" id="A0A1Y1UEI3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="137" mass="14563" checksum="1FA9EBAE47996D9B" modified="2017-08-30" version="1">MPAPRSTCEPCHRRRVKCDLPDQISGECSNCVKRGIKCPGLRVAGPRKPRKGTVVDQIQRDFGSIEVLNGDSTSPEAGPSNYASHSSSPAPWALTSGAQWAMASPPTPTSTENSLATIELSGELAMSMILNFNISHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEK4</accession>
    <name>A0A1Y1UEK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870559.1">
        <property type="nucleotide sequence ID" value="XM_022018376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEK4"/>
    <dbReference type="GeneID" id="33560185"/>
    <dbReference type="InParanoid" id="A0A1Y1UEK4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="256" mass="28364" checksum="263A562022188963" modified="2017-08-30" version="1">MAMATTPPSTPKQAVTASLRDLFTPPPTVHRDECGKRKFWKQRFPPLVVPADEPDAPLFSPYETSIRLPDSPSPMSNSLGTELDRHNGKRSRSVTAVDDESDDEIQYLHTVTAAPNRRRKLVKDEPGSSCTKGPLFMPQDEDDHHGPNSMPQAHATKKLASPVRSHTEPDDDYFEILGTPSTPLRQVDDGEARRDPDQSCRACGCTCRARSPVEEEERARPVPRGSGRRRLSRRVMGNLLGEFAAGEPTSACEIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEW2</accession>
    <name>A0A1Y1UEW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_630001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870183.1">
        <property type="nucleotide sequence ID" value="XM_022016280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEW2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEW2"/>
    <dbReference type="GeneID" id="33558089"/>
    <dbReference type="InParanoid" id="A0A1Y1UEW2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001312">
        <property type="entry name" value="Ras-related protein Rab-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="207" mass="22914" checksum="C1CBCC9FEEE0341F" modified="2017-08-30" version="1">MSDGLPMNLKLLLIGNSSVGKSSLLLRFTDDEFLSDEETSATIGVDFKVKSIEVEGRRYKLSIWDTAGQERFRTLTSSYYRGAQGVVLVYDVSSRQSFDELLKWFTEIDIHCGEGVVKMLVGNKVDKEASRQVTTDEGKTFAERMGTLFIECSAKTRVGVMEAFQELVMRILDTPSLWNRNSNGIRADNGTIQPGNESSGLLGGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEW5</accession>
    <name>A0A1Y1UEW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870680.1">
        <property type="nucleotide sequence ID" value="XM_022018266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEW5"/>
    <dbReference type="GeneID" id="33560075"/>
    <dbReference type="InParanoid" id="A0A1Y1UEW5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="285" mass="30957" checksum="3540033DEA08357D" modified="2017-08-30" version="1">MTTIARPSTPFPHTASLSHSASGSNHHKMTLPPTYHYTTPIHFAPKALPTPTPPSLLARTSSTGSNSSGHYIHLRRSSSARQSPAGEDLSRTPSLVPASPRRGSASSSLLVLTPPSTSTLLLPEVEEDADADDDVDDVEEMDAEESPELPKSRSAGFALPPPTYNWSDKPIEPDTTFDFDSSFSSSPASRLENWITTSNSVTPSNPFRRPALKRRDTPRPSIEQAPKSLKRPAFRRRSTPPPPPSSRASHLRLSPLKEVAESSLSTGQKLRSVITGSQWVVVDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF28</accession>
    <name>A0A1Y1UF28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein REV1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_656542</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870712.1">
        <property type="nucleotide sequence ID" value="XM_022018844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF28"/>
    <dbReference type="FunCoup" id="A0A1Y1UF28">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF28"/>
    <dbReference type="GeneID" id="33560653"/>
    <dbReference type="InParanoid" id="A0A1Y1UF28"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="143"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="15">
        <location>
            <begin position="441"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="830"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="961"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1106"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1115"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1126"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1266" mass="139871" checksum="EFD7EC4F9FE64562" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF51</accession>
    <name>A0A1Y1UF51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative negative regulation of gluconeogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_651106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870688.1">
        <property type="nucleotide sequence ID" value="XM_022018267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF51"/>
    <dbReference type="FunCoup" id="A0A1Y1UF51">
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    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF51"/>
    <dbReference type="GeneID" id="33560076"/>
    <dbReference type="InParanoid" id="A0A1Y1UF51"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="386"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="386"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="470" mass="52032" checksum="94572E193DD6B474" modified="2017-08-30" version="1">MPAGPPGSSSGQLILEEPLIRTPYELLRRSHRSAQRQVEKDFKIIQSGLNDLVKRASTAEPGPSSHDSVIKQLDQVGERVKGLKRKLDDLQPREDAPSVLKSRLKYVESLGKGEKTASEHSSLAPPETEAGTDRTLDRYIVDYLLRTGRVKAAQALAVHQGIEDYADIKLFAELTKIEKALIERRSVTEALAWCGENRGTLKKTKNDLEFALRLQEFIELCRHRDVTGAITYSRKNLAAWAPTHMQEIQQGMTLLVFGERTGVSAYRKLYETERWQHVRHQFRETFLNLYGLPTQPLLALALSAGLSSLRLPSCAPHVKPSTSPLSPKSPTVPLLPSAPSLHDLEQVLSTIGAGIDHLTAPIGGVPTSPEDDMHEHPETLVGNVDCPTCGEDMKILASEVPMSHHVNSTIVCRISGKVMDSQNEPMAFPNGHVYSSKALEEMANSNFGCVTCPRTRQTTVFTRLRKVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF52</accession>
    <name>A0A1Y1UF52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZIP zinc transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_581562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870273.1">
        <property type="nucleotide sequence ID" value="XM_022013512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF52"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF52"/>
    <dbReference type="GeneID" id="33555320"/>
    <dbReference type="InParanoid" id="A0A1Y1UF52"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012305031" evidence="7">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="498" mass="52918" checksum="55C30780AB686842" modified="2017-08-30" version="1">MVKASQVLFFTLLSSSGIQAQLVPVPFNPIATSLGPAPTESIGCLIRDGDWSCAAARQTVVSSRVQSTGTSNASPNSASSTSISPPPTESSSCVLHGDHYHCDEDHSDGTPTIGHPSIASSTQSSNCVWHEIHWDCFESPEEADPAHQADELGECIIHVGHTHGDCSAEQLACGVVLLEDYHMPLHIGSIFIVLITSGLGVLIPILTFWFRKGNDGSELDLESGARFGRETGIWGNVFFLARHFGSGIIMSTAFIHLLYHGFVMFANECVGDLLFESTAPAIAMAAAVLTFMLDLVGRRYMHSSGMEDTPQLPGIDKTEILPPANHGIGHGHHFDAALAAERSWQTLLLEAGIIFHSIMIGVTLGASSGDGWTTLLIVIVFHQFFEGSALGVRIALLSWLSKWKTLSMGLAFTVSCTVGIGIGIGVRGSFSQNGKASLLSVGILNSISAGILLYTAFNLLAEDFVNGPLRRAGLFKVVSALAAFFAGLVAMSVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF85</accession>
    <name>A0A1Y1UF85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_464180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870800.1">
        <property type="nucleotide sequence ID" value="XM_022012858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF85"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF85"/>
    <dbReference type="GeneID" id="33554666"/>
    <dbReference type="InParanoid" id="A0A1Y1UF85"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="57"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="190" mass="21042" checksum="264A4156E1A97299" modified="2017-08-30" version="1">MAMSRDDTKRYPYLLAAATVQSSPSTGTSGANQLEEDVDMDDERVDAHARPGLARPTYLAIDTNIFLDKLRLVKALHTFLSTTLAGCILVPSAVINELDSLSKSDIVAGVSPEGDVHLSDLARVATAWLLQVARKPKEERVIRCQKWSERLDTELRKGDDKILDCCLFFAREAKVSLWTNDQNLSLLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFF9</accession>
    <name>A0A1Y1UFF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_627151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870852.1">
        <property type="nucleotide sequence ID" value="XM_022015969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFF9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFF9"/>
    <dbReference type="GeneID" id="33557778"/>
    <dbReference type="InParanoid" id="A0A1Y1UFF9"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="161"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="466" mass="51301" checksum="829D00F4AFDAD6C8" modified="2017-08-30" version="1">MSYTSLLTPVASSSKGVIRGIMPPNSSSASFIRLPCRHRTLCTERVLLRSPPVTSAFYYRSSSSTPSRRPKLPEITSEGSSRITPVSPRPEVRPPDATPAEGTQTPPLTARPSLMERLKNPSPARLRFLKILGWSMLFSAAVHVGLVIYVMKNDSGELSPDEHMPRVVSKITRLSPRHRYIEIPVDPESCKQFGDQAMGMDGEKLKSEKGAVAVQHVTIKSPAIQVERSYTPINDVQEDGLLKMVVKRVKGGEVGRIVFSAKEGERIWVRGPITTFAINPYQFDRIVMISTGTGVAPFLQFLSKFNPSSSPFPSNDLERDDLNPLNTSSSPSQPLPKLLLLHAMPSEDHAEADWPVSTGCIPRLESKFGPLLDVRRFPSGDVPSSSISSALGMGDGPDHHSTWLPWKGSAKSEPLKRDERVMVLVSLPPAMMDPVCGRMTSEFQQGELTGILKELGLKPHQVWKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFM9</accession>
    <name>A0A1Y1UFM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_651333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870922.1">
        <property type="nucleotide sequence ID" value="XM_022018316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFM9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFM9"/>
    <dbReference type="GeneID" id="33560125"/>
    <dbReference type="InParanoid" id="A0A1Y1UFM9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="539" mass="59423" checksum="DE3DD3C9523C4DCD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFS4</accession>
    <name>A0A1Y1UFS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formin homology 2 domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_592002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870054.1">
        <property type="nucleotide sequence ID" value="XM_022013810.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UFS4">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFS4"/>
    <dbReference type="GeneID" id="33555618"/>
    <dbReference type="InParanoid" id="A0A1Y1UFS4"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="259"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="914"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1662"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="718"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1663"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1698"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1741" mass="191828" checksum="BD279DE4819FA072" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG00</accession>
    <name>A0A1Y1UG00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_479323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871017.1">
        <property type="nucleotide sequence ID" value="XM_022012899.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UG00"/>
    <dbReference type="GeneID" id="33554707"/>
    <dbReference type="InParanoid" id="A0A1Y1UG00"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39223" checksum="DD59933366B2E714" modified="2017-08-30" version="1">MDLASTSSPETVKTHLDDRDDSDTFERTPEGLGFMDASKSVLELSWELFPPGHSSLSPSIAPRRRRGTVRSEAVKPIQVQVNLQQDLGLLKASKGDTGSVLWRSSYYLAHNILRQHHFAPSSSSLPLINAATLAKTRILELGSGTGLLAIVLQNLCGQFTASDRWENLKLIKRNLELNKVKARDLDEGGQRSPTSLKSTRKPSLARHTSHDRHKFQDDSNGGSQAKHDQILLEEIDWLAISQERKSDQKSSSQAQARPMPAYDLILCVDCIFNEHLAQPLVDTLVKYCPKGGQTIVWVIVELRSSDVLSKFLETWFNDPSGPWTIVRLSHASMGDWNGRRPRWVGWVGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG68</accession>
    <name>A0A1Y1UG68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_629123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870607.1">
        <property type="nucleotide sequence ID" value="XM_022016176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG68"/>
    <dbReference type="GeneID" id="33557985"/>
    <dbReference type="InParanoid" id="A0A1Y1UG68"/>
    <dbReference type="OrthoDB" id="4725912at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26553" checksum="94DD41DCAF35A34E" modified="2017-08-30" version="1">MSDQPPPSSGLPDYSEVDKAKTDSVAEENLDTTPSVPYSSHSLKVDYQWRKKEVKISMASDTTDKPVYIADYHWMTNPTLVIKRCSDDLTIGTGNSQAISINPSYTFGDYNGELRASSRFLTRYTFESQHYKVKPEILHWSANMGIKNWDFTCFDKDEVPVAKFHSNVWYIKKIGLLDFYEPCDENQSLREEIMVVAMTMYNQMLIRINSPLSILGMIPNPKPHKEEEVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGE1</accession>
    <name>A0A1Y1UGE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_626371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870645.1">
        <property type="nucleotide sequence ID" value="XM_022015889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGE1"/>
    <dbReference type="FunCoup" id="A0A1Y1UGE1">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGE1"/>
    <dbReference type="GeneID" id="33557698"/>
    <dbReference type="InParanoid" id="A0A1Y1UGE1"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="180" mass="19902" checksum="D0B7403E9EC94F85" modified="2017-08-30" version="1">MASLSSTFARRSILKAVGTAPTLRCAPSLLLCQKRFATTEAVSSQDEIAILNNQRLKRPISPHLSIYQPQMTWYPSMFHRLTGVALSGGLYLSALAYLTHPYFPALDSAHLVQLVHDSPVWLKGSIKMLFALPFTFHSFNGIRHLLWDVGYGLTLKGVYAGAYAVIGLTTVSSIWLAFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGT9</accession>
    <name>A0A1Y1UGT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_650885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871319.1">
        <property type="nucleotide sequence ID" value="XM_022018226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGT9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGT9"/>
    <dbReference type="GeneID" id="33560035"/>
    <dbReference type="InParanoid" id="A0A1Y1UGT9"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="48"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="262"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="41191" checksum="EC26EDF263CE5003" modified="2017-08-30" version="1">MPPPSGAKWCTPCPKPFSDHVYKTVQGVDVPLRIWPAENPSDEPLPWLLWIHGGGWAGGYHTRMVGWVHPAFHGRQYHIVSVGYRLIPHVGFNEQVEDLVDSFKWCREHLPTMISVDLERYAVAGDSAGGYFSSLSPHIFSPAPKAIINIYGPTNFTGPWANPTPLSPEELDAAFSKIEFLDSDRKREQLDAYWAERDPSKAMTVAPWWWEFDIPQGEHEAYHGVTSVNRGDEERLVMDVYRWVAATRTRITNWFRKEDFNSQEEYDKFVRKASPLFGITKDHPPTFILHGTADTAVPIEQNYVYEKTLKEAGVPVNSRYDEGGEHSFDARILDEKSEDWQMYIVPAMDFIDQHVKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH13</accession>
    <name>A0A1Y1UH13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871378.1">
        <property type="nucleotide sequence ID" value="XM_022015833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH13"/>
    <dbReference type="FunCoup" id="A0A1Y1UH13">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH13"/>
    <dbReference type="GeneID" id="33557642"/>
    <dbReference type="InParanoid" id="A0A1Y1UH13"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="445" mass="49418" checksum="77655B4B5BB67FA8" modified="2017-08-30" version="1">MPKALKSSKPRHDPLHVELAQDDTYRKFGRSAVNGKKKAKVVEEEDEEQVGEDARMSKKILDLARDQQAEIAREIALNDDEEDDDLEDDDTPGPSTRPRPMEMPSDDEEKDEDAEDSDVELDIDPEDHATLDALAPEQNGRTLADIIFNKMAGGAVSQGAAAEEEDEGPPDPRKGLNPKVVEVYTKVGFLLSRYKSGPLPKALKILPSLPHWAQLLALTGPTQWTPHATFACTKIFVSNLKPSDVRVYLEGVLLDQCREDMRMNNGKLNVHLYEALKKSLYKPAAFFKGILFPLCETACSLKEAAVVASVLAKVSVPVLHSAAALLRLASMDYSGPNSLFIRILLDKKYALPYKVVDALVFHFIRLANSSRSKDGDDKLPVLWHQSLLVFVQRYGSDLTPDQKDALLDVIRVRPHASISPEIRREIINSVERGAPRPDDDDVAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH67</accession>
    <name>A0A1Y1UH67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dbl homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_579738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871410.1">
        <property type="nucleotide sequence ID" value="XM_022013406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH67"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH67"/>
    <dbReference type="GeneID" id="33555214"/>
    <dbReference type="InParanoid" id="A0A1Y1UH67"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="307"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="534"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="769"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="920"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="839"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1269" mass="144725" checksum="F63F2A0F4DEFAF14" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHA1</accession>
    <name>A0A1Y1UHA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">mRNA export factor elf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_627650</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870976.1">
        <property type="nucleotide sequence ID" value="XM_022016021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHA1"/>
    <dbReference type="FunCoup" id="A0A1Y1UHA1">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHA1"/>
    <dbReference type="GeneID" id="33557830"/>
    <dbReference type="InParanoid" id="A0A1Y1UHA1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="456"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="698"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="995"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1021"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1106" mass="118997" checksum="935797DD62FEAC67" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI83</accession>
    <name>A0A1Y1UI83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_622870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871676.1">
        <property type="nucleotide sequence ID" value="XM_022015523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI83"/>
    <dbReference type="GeneID" id="33557332"/>
    <dbReference type="InParanoid" id="A0A1Y1UI83"/>
    <dbReference type="OrthoDB" id="2576031at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="355" mass="39448" checksum="18A81CEA84C9C191" modified="2017-08-30" version="1">MEDQPEASGSSSRAARPSSNEVRLGRRVLELEHERDTLLAEIRDLRSRRSSEGASSSSLAAQTSSQPRMAIPDELLPTLTLLRNHIRDLTRDNEALRYTFVGISSNPSALNERDAGPSRSLVDLGEVVVRVRELMQENEELGQMIIEAGRSSDEEWQKLIADARKVIESLESDLEQHANIVESQRAEIDRYKAEIESLRSPASSSSRPRFSGGSSYSPLSHDMGTEYGSSSSHVHGQGRNQRSMTNESRNSNRSKDGRPSSGHGSRGNMNRRQDGDRERDKDRSGPRDKGRSSDRRQSNTGNTQRQIGQNPRVGPSETRDEQDGLESELRGLNIRDAQSKPAPQQPKRTRGPGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI94</accession>
    <name>A0A1Y1UI94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_625206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871244.1">
        <property type="nucleotide sequence ID" value="XM_022015777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI94"/>
    <dbReference type="FunCoup" id="A0A1Y1UI94">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI94"/>
    <dbReference type="GeneID" id="33557586"/>
    <dbReference type="InParanoid" id="A0A1Y1UI94"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="82"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="748"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="988" mass="110243" checksum="AB1F54C79A33A2E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIE9</accession>
    <name>A0A1Y1UIE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosylmethionine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_651352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870944.1">
        <property type="nucleotide sequence ID" value="XM_022018321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIE9"/>
    <dbReference type="FunCoup" id="A0A1Y1UIE9">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIE9"/>
    <dbReference type="GeneID" id="33560130"/>
    <dbReference type="InParanoid" id="A0A1Y1UIE9"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000017">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="483" mass="52567" checksum="A8AF3E0F05C5B90A" modified="2017-08-30" version="1">MTVPAEITVTPEDATFPGPFEGPEKLLEVWFAPSFDLLPEPSTPLKKRVPTHELDKLDLSSTNGESGDGAATGGIGSSVKRKGLRIVPRAVWEEMLDIVKCKVLSVVEGDELDAYLLSESSLFVAPHVLILKTCGTTLNLLGLHRIIEIAREYCGFTNIWRCFYSRKSFFFPERQSGPHKDWRDEVTFLDSVFCSAGSAYTVGPMNRDHWLLYLTSPDTLPLLPSDSSLSNSSFRLSLPCPGRPPPTYQDQTLEILMTHLSPSARAPFFHAEATSSGSSLTGHELGLGISTRLGIDKLFPAYETTLDSYGFDPCGYSANAVIGSGMPEASSVPGKPGGGYFTIHVTPEEGWSYASFECNVPLPMASSSSTPSITPSSSNDSVSRPHLTQLIRNVVGIFQPSRLSITLFVSTPPSSSSSSSSSSGTDQGPTSTSETEARAWQAFSMDLLGEGYTRKDRIGYEFDGYDLVFACFEKRGWVEEKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIQ8</accession>
    <name>A0A1Y1UIQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_650462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871908.1">
        <property type="nucleotide sequence ID" value="XM_022018149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIQ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIQ8"/>
    <dbReference type="GeneID" id="33559958"/>
    <dbReference type="InParanoid" id="A0A1Y1UIQ8"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="523" mass="55516" checksum="08C89C57C1A70CBE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJL7</accession>
    <name>A0A1Y1UJL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_620135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872173.1">
        <property type="nucleotide sequence ID" value="XM_022015251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJL7"/>
    <dbReference type="FunCoup" id="A0A1Y1UJL7">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJL7"/>
    <dbReference type="GeneID" id="33557059"/>
    <dbReference type="InParanoid" id="A0A1Y1UJL7"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="533" mass="59392" checksum="47FAADBC0780379F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJW9</accession>
    <name>A0A1Y1UJW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_649723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872270.1">
        <property type="nucleotide sequence ID" value="XM_022018038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJW9"/>
    <dbReference type="GeneID" id="33559847"/>
    <dbReference type="InParanoid" id="A0A1Y1UJW9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="153" mass="16971" checksum="99D8C636EA4D28FC" modified="2017-08-30" version="1">MTSQHSTKQTATYSYSIGTLHTGTAGAPTVHRVSEEGNPLVFIVKPSEGFEEIEITDEHRTELADIDAELGEVAERFLKEEIERCRSQRGAPDLEASTQAICRALTNYADSHNKLSSALWELGPADTFDELMTVGEYSTWKEYLENGAQESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJY6</accession>
    <name>A0A1Y1UJY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative death-receptor fusion protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_623421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871801.1">
        <property type="nucleotide sequence ID" value="XM_022015580.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UJY6">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJY6"/>
    <dbReference type="GeneID" id="33557389"/>
    <dbReference type="InParanoid" id="A0A1Y1UJY6"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="599"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="4">
        <location>
            <begin position="844"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1452" mass="160237" checksum="92D09BA72B1AE2CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK43</accession>
    <name>A0A1Y1UK43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872343.1">
        <property type="nucleotide sequence ID" value="XM_022015323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK43"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK43"/>
    <dbReference type="GeneID" id="33557131"/>
    <dbReference type="InParanoid" id="A0A1Y1UK43"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF26">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="901"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="542"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1161" mass="128502" checksum="7D109C058880BF71" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL02</accession>
    <name>A0A1Y1UL02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872096.1">
        <property type="nucleotide sequence ID" value="XM_022018011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL02"/>
    <dbReference type="GeneID" id="33559820"/>
    <dbReference type="InParanoid" id="A0A1Y1UL02"/>
    <dbReference type="OrthoDB" id="2562958at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="43105" checksum="480028D9CE902689" modified="2017-08-30" version="1">MSGPATASPLVEAFYSTVTQALCVGAVVKGCDYSLRRWLAVSTLTPPEVALHPSEPPKNAKWKLRAIGLSIFAFFMAFEGGLIFGAQRIKSEFWLNALWAGIEGLLITLVLFTSSLIFFPARIELSYIANKLDPGAIVLKEKREDTVWPRIFGAAGVSALCIYLSSQNIRALQPVVVAAWVLMCLATANMPKMNVKWANIVLMGYITVVPVIGIVLGGLITLVLGFFGENGETAAPSEPKPELYGWLGRVMIMVMSGLPCMMAGVLISLALRFDHAQTRSFIALRGEPGQAAIIPTSSPDFAKPMFRASVAALTASLVVAEVLTSIFEPTHSVEMAWIFMTIPTVCAVQLITAKRMGTLKDWWKYEEIWIPSKEDVAKIAQDIEAVAPVEEKPAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULG8</accession>
    <name>A0A1Y1ULG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_296883</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Preautophagosomal structure membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872754.1">
        <property type="nucleotide sequence ID" value="XM_022012411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULG8"/>
    <dbReference type="FunCoup" id="A0A1Y1ULG8">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULG8"/>
    <dbReference type="GeneID" id="33554219"/>
    <dbReference type="InParanoid" id="A0A1Y1ULG8"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000003">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000347">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="16">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="15">
        <location>
            <begin position="208"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="14">
        <location>
            <begin position="302"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX38891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="394" mass="43721" checksum="3CBB9D3AAA42E3F6" modified="2017-08-30" version="1">MTRVSRLDLLPLNNNLFSRELEERERRLGQAHLDTFSFRSSLAAFAMSTHSAQSSTNLFRRLAWQSSIHLFIRLADGEPGAGSGSDRYYMQAPRHSYLPLLLPEIRENLVELALDDQQLADTDEKDWWFEEEVEEGSSVFVSQGPCRWHWPLDLIELYSFISRSAASSSDPTASSSTSASSSKSRPLRLLLHLSNPPADKLLLNNTVEACKTQYINQVKEADFVRWRNTTKVTNLRRADLEAGWDGIVQDDYDLYMRMASRILPLPIAAGAPSPSIPSRPPSTDPGSSGPSKPESAYTTRALPVKLYLPDNAPVIQEVVPPMTADGMPLSILALLRQHLPLLFPALNEKGSPYDLAIPVAQGIEIPPEAEVAWLSACMCGVDGWLRIGIQLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULJ5</accession>
    <name>A0A1Y1ULJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_620651</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872306.1">
        <property type="nucleotide sequence ID" value="XM_022015307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULJ5"/>
    <dbReference type="FunCoup" id="A0A1Y1ULJ5">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULJ5"/>
    <dbReference type="GeneID" id="33557115"/>
    <dbReference type="InParanoid" id="A0A1Y1ULJ5"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="397"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX38384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="47699" checksum="25C092C1FB731AE5" modified="2017-08-30" version="1">MLLQLLRPSRTTVHKQIQAQINSLTMSLSSKLSIKDLDLKDQRVLIRVDFNVPQDKELNITNPARIVAALPTIKYAIDNGAKSVILMSHLGRPDGSPNSKYSLKPVASKLSELLGKDVKFLDDCVGEKVKEEVLAGKDGQVFLLENLRFHVEEEGKGKKGDEKIKADPENVKKFRDDLTALGTVYINDAFGTAHRAHSSMVGVELPQRAAGFLMKKELEYFAKVLENPERPFLAILGGAKVADKIQLIDNMLDKVNTLIICGGMSFTFKKTLDNVEIGQSLFDEEGSKKCKELVEKAKKNNVKLVFPVDYVTADKFDKDAKTGSATDESGIPSDWMGLDAGPKSRELFSQAVSEAKTILWNGPAGVFEFPAFAGGSNALLDACIKAAKGGAQVIVGGGDTATLVANAGKEDELSHVSTGGGASLELLEGKTLPGVAALSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM19</accession>
    <name>A0A1Y1UM19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_680259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872456.1">
        <property type="nucleotide sequence ID" value="XM_022019074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM19"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM19"/>
    <dbReference type="GeneID" id="33560883"/>
    <dbReference type="InParanoid" id="A0A1Y1UM19"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="18"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="578" mass="64219" checksum="07DA621CE065F553" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMG4</accession>
    <name>A0A1Y1UMG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_655690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872247.1">
        <property type="nucleotide sequence ID" value="XM_022018821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMG4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMG4"/>
    <dbReference type="GeneID" id="33560630"/>
    <dbReference type="InParanoid" id="A0A1Y1UMG4"/>
    <dbReference type="OrthoDB" id="3357304at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="709" mass="76494" checksum="D9E0D3AC21004560" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMN4</accession>
    <name>A0A1Y1UMN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal recognition particle, SRP9/SRP14 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_619251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873186.1">
        <property type="nucleotide sequence ID" value="XM_022015150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMN4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMN4"/>
    <dbReference type="GeneID" id="33556958"/>
    <dbReference type="InParanoid" id="A0A1Y1UMN4"/>
    <dbReference type="OrthoDB" id="360923at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.10:FF:000008">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="157" mass="16246" checksum="D25DFA2C8F29D500" modified="2017-08-30" version="1">MVYIKSWTDFETAATDLYAKGPTKVRYLVKFLPKTGQLALKLTDDTTCIKYKTFSSIILNRFESLNLRLLSQMTNSRPRIQQSTLSGTAGGAERATSPGLEGDDPMTGAGSQPPEPASTDKASGGAAATPSKKGTAGSTGGGAGGGGGGKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNL6</accession>
    <name>A0A1Y1UNL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_614482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873433.1">
        <property type="nucleotide sequence ID" value="XM_022014599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNL6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNL6"/>
    <dbReference type="GeneID" id="33556407"/>
    <dbReference type="InParanoid" id="A0A1Y1UNL6"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="138"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="229" mass="26407" checksum="D3A97514F3BECCB7" modified="2017-08-30" version="1">MWLRRLEWATDEQLDRISEIWSTSLRDAWIVQANHGFDQTIVSRAFRYRAQVGVTDACVWVAGEKEGEIQGAMHVFPKGCDIWVSKTAKSAWPTWQDAMDPQVYAWKLREVSPRLDDLYDRACRKYNTTLKESIFLSVIGVDTKAQRRGIGEALMSVLKKEAVKLNTIICLACGEEDTVRWYEKAGFEDVLSDAMDIRGRQGRVHVMLWRASMEGRSTNPRHCSEWSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNP0</accession>
    <name>A0A1Y1UNP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_614517</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873443.1">
        <property type="nucleotide sequence ID" value="XM_022014606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNP0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNP0"/>
    <dbReference type="GeneID" id="33556414"/>
    <dbReference type="InParanoid" id="A0A1Y1UNP0"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="4"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="912"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="708"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="788"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="957"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="969" mass="107981" checksum="E7E4CD74168CE5FD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNQ1</accession>
    <name>A0A1Y1UNQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_618702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873030.1">
        <property type="nucleotide sequence ID" value="XM_022015070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNQ1"/>
    <dbReference type="FunCoup" id="A0A1Y1UNQ1">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNQ1"/>
    <dbReference type="GeneID" id="33556878"/>
    <dbReference type="InParanoid" id="A0A1Y1UNQ1"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="27639" checksum="07A37686ED31A80B" modified="2017-08-30" version="1">MRLTPDVVSKTPSHLNALKERELDLRGLQIPVIENLASHQGTYDTLNLTDNSLTVLGNIPLSTRLQALHVGRNQISSISVSLPANIPNLVTLVLSDNVISSLATLAPLESLTHLQHLSLTGNPITQHEHYRLFVIWKVGRGSLRTLDFKRIKDSERAAAKKLFVDSTTSLPNALANRLSTSTAAVSGSTGLTKGSAGGAGAAGGGPLKGGKGRLMTPEEKKKVVEALTRAKTADQVRKLERMLAEGLIPEGEEGVPVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP39</accession>
    <name>A0A1Y1UP39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_322411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873137.1">
        <property type="nucleotide sequence ID" value="XM_022012482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP39"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP39"/>
    <dbReference type="GeneID" id="33554290"/>
    <dbReference type="InParanoid" id="A0A1Y1UP39"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000005">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="114" mass="13526" checksum="91C815B31129B7A9" modified="2017-08-30" version="1">MSKYNQKPFTQEEKRKAIEQYSEKIQYSARYSNDEWEYRHVIIPKPLLRFTPPGVCPEDVWRGLGIRQSPGWEMYMRHDPEPHVLLFRRPKNYDLIHPPFSAVGAARLVNVGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP45</accession>
    <name>A0A1Y1UP45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_607387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872748.1">
        <property type="nucleotide sequence ID" value="XM_022014068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP45"/>
    <dbReference type="GeneID" id="33555876"/>
    <dbReference type="InParanoid" id="A0A1Y1UP45"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="193" mass="22215" checksum="72F3350EA5A27A57" modified="2017-08-30" version="1">MITQPFLSLLYFPSVQLTRRSQIDLFPPCNLHAHLVVSTYCKTQASVHQSYPFLIEGPCTYKTESLAQVEEAYQVLQQTEDSVATSANPKAPSALFTLEQFDALNQQIIKMQGLLQMLEMQCQDSMDHLKKHVPDAMPLILIPSKAQQLPCLDPCNIWEDAQRWKTYLREHINRFIEAHLMVTQAHCNRLMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP49</accession>
    <name>A0A1Y1UP49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_619163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873157.1">
        <property type="nucleotide sequence ID" value="XM_022015133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP49"/>
    <dbReference type="FunCoup" id="A0A1Y1UP49">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="GeneID" id="33556941"/>
    <dbReference type="InParanoid" id="A0A1Y1UP49"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="404" mass="43240" checksum="B13E1163833AD99C" modified="2017-08-30" version="1">MSKPNLFAPTPVGSRPASPPPGYPMESETDRDRRDAQSLLMSQLGGADRAKENAQGRNDVGPPSTRDQALPILSYCAASIMMTVVNKYVVSGANFTMTFLLLAIQSSVCVLAVWSVKRMGMINFRDFDKNDAKVWLPVSSLLVAVIYTGSKSLQFLSIPVYTIFKNLTIILIAYGEVFMFNGMVTGLTLVSFALMVGSSIIAAWADISSAFRSPAPIDPYTGLETPALRATIGSINAGYIWMALNCLASAGYVLFMRKRIKLTGFKDWDSMFYNNLLSIPILVVASIIIEDWGTESLAKNFPASNRVLLLSAMAFSGAAAVFISYSTAWCVRVCGSTTYSMVGALNKLPVAASGMLFFGDPVSFGNVSAIGVGGLAGIVYAVAKTNQARVDAANRSRVLPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP61</accession>
    <name>A0A1Y1UP61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_617845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872768.1">
        <property type="nucleotide sequence ID" value="XM_022014954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP61"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP61"/>
    <dbReference type="GeneID" id="33556762"/>
    <dbReference type="InParanoid" id="A0A1Y1UP61"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="62"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="247" mass="28170" checksum="C35DCAEA7AF3F72B" modified="2017-08-30" version="1">MGGSFSIAAEPSKAPFVEPTGINPADKTADLSDPLHRYGQYLTTCLPKYIQQFSVYKDELTIYIPPSAVVPVLTFLRDHSQCQYKAVMDITAVDYPTREMRFEIVYNLLSVAHQSRIRVKTYADEITPVPTAVGVFNGANWYEREVWDMYGVFFDGHPDLRRILTDYGFEGHPLRKDFPLTGYSEVRYDEEKKRVVYEPLQLTQAFRNFQDAASPWEQVGAGDAKAHPENFKLPPPPPPEDAKDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPF2</accession>
    <name>A0A1Y1UPF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylenetetrahydrofolate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_304217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872878.1">
        <property type="nucleotide sequence ID" value="XM_022012436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPF2"/>
    <dbReference type="FunCoup" id="A0A1Y1UPF2">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPF2"/>
    <dbReference type="GeneID" id="33554244"/>
    <dbReference type="InParanoid" id="A0A1Y1UPF2"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000022">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NAD+), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000401">
        <property type="entry name" value="Related to MTD1-methylenetetrahydrofolate dehydrogenase (NAD+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="2">
        <location>
            <begin position="185"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="362" mass="39634" checksum="D097BB8964768560" modified="2017-08-30" version="1">MADTAPQGLLVTAGKVHVPFKTELLNTLASPRFSTKPPHLVGILATRKEDARTYAEFTKRSCEQVGITFELRLVGEAREGMDHGGVGIDVEEAILEANNDREVDGIMVYYPIYGGRQDQYLQSVLSPLKDVEGLNHQFLFNLYHNIRFIHPLTLRAPSSASTLPLASPASGIERAPEGTVKSVLPCTPLAIVKVLEHIGVYNRMLEYGDRARGKVITVINRSEVVGRPLAALLANDGARVLSVDIDSIVEFSKRPSSSTQSSQFNAHHIVSTLPDDFKLANALAISDVVISAVPVQSYKVPTKDLKDGCICVNVAGEKNFEKDVRERASIYVPSVGVMTIAMLQRNLLRLCEYQDEAKRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPF6</accession>
    <name>A0A1Y1UPF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_641440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873257.1">
        <property type="nucleotide sequence ID" value="XM_022017420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPF6"/>
    <dbReference type="FunCoup" id="A0A1Y1UPF6">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPF6"/>
    <dbReference type="GeneID" id="33559229"/>
    <dbReference type="InParanoid" id="A0A1Y1UPF6"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="711" mass="77300" checksum="57E001CDB7B7A67B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ64</accession>
    <name>A0A1Y1UQ64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_614682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873492.1">
        <property type="nucleotide sequence ID" value="XM_022014628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ64"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ64"/>
    <dbReference type="GeneID" id="33556436"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ64"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="278" mass="29435" checksum="D5937449E2C35EDE" modified="2017-08-30" version="1">MALQTPSLSLYITNIESKVKKPELRSQLYALFTPYGRVIDVTAKKHDGGRGQAFVTFDDQASATSAMRGLTGESFYGKPLSITYSKKPSNATLSRLDPSASRDAAAIKAAKLVVSRAQGEYEQLEKEREDEEAGRGGGGGGAGAKRDLEDGEGGDASGRNTKKPKVEEDEAMEIEMDEDEDEGAAASSSGGVALLCSNLPPECNEMVLSALFGQYAGFTKASPLSSSTSLPSSHSKQNPGAKSFRVTFGSKAEAEAALQPTKGYLMQPGWEMNVSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQA1</accession>
    <name>A0A1Y1UQA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_616997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874025.1">
        <property type="nucleotide sequence ID" value="XM_022014871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQA1"/>
    <dbReference type="GeneID" id="33556679"/>
    <dbReference type="InParanoid" id="A0A1Y1UQA1"/>
    <dbReference type="OrthoDB" id="2581067at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="184" mass="19521" checksum="AB81D94D164FCECE" modified="2017-08-30" version="1">MDHLPSLTFSSGQLAVSSNFWPISQPTPDVPWIINGTNYVSWICGGASGIPSFDIQLLNHNKSIMVGFIPIALRVPMARLPTGQKNFGGELQIELGEDIPTGDGFSLVFLSSLHGQVYAKSKPFSILPAAPSNYTEPVLPTATVTAILDTLPNPTQQWALTLNGIDPDALETQAAAIAGNVGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQF9</accession>
    <name>A0A1Y1UQF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_615029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873582.1">
        <property type="nucleotide sequence ID" value="XM_022014673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQF9"/>
    <dbReference type="FunCoup" id="A0A1Y1UQF9">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQF9"/>
    <dbReference type="GeneID" id="33556481"/>
    <dbReference type="InParanoid" id="A0A1Y1UQF9"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000021">
        <property type="entry name" value="Ornithine decarboxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="10">
        <location>
            <begin position="113"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="522" mass="56663" checksum="1145E0B63CF28DB4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQH1</accession>
    <name>A0A1Y1UQH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_607304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874068.1">
        <property type="nucleotide sequence ID" value="XM_022014061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQH1"/>
    <dbReference type="GeneID" id="33555869"/>
    <dbReference type="InParanoid" id="A0A1Y1UQH1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="609" mass="66650" checksum="955671640BCF9C0F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQI2</accession>
    <name>A0A1Y1UQI2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Allantoicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_269449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the allantoicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874034.1">
        <property type="nucleotide sequence ID" value="XM_022012335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQI2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQI2"/>
    <dbReference type="GeneID" id="33554143"/>
    <dbReference type="InParanoid" id="A0A1Y1UQI2"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="6">
        <location>
            <begin position="205"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="780" mass="85642" checksum="B620E3DE6FC3527E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQI9</accession>
    <name>A0A1Y1UQI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_607317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874088.1">
        <property type="nucleotide sequence ID" value="XM_022014062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQI9"/>
    <dbReference type="FunCoup" id="A0A1Y1UQI9">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQI9"/>
    <dbReference type="GeneID" id="33555870"/>
    <dbReference type="InParanoid" id="A0A1Y1UQI9"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="467" mass="49484" checksum="7B52A308ACA36458" modified="2017-08-30" version="1">MHPIAQVARRQAAASLHRHVVQRGFHISATSSALTKFQMPAMSPTMTEGGIASWKKKEGDSFAAGDVLVEIETDKATIDVEAQDDGILAKIIEQDGAKGIAVGTPIAIIGEEGDDLSGADKLASEPSKASASQTDPPKKDSGAEKADPEKETKPGTASGQTTPALQTPSDQTKYGSGGGTDAPKAPEKPGSGGDKPKFFASPLARKLALEKGVPLGEIKGTGPQGRILKGSASSAPAEYEDVPLTNMRRTIGKRLLEAKQQIPHYQVTVEINMDRINKLRELFNKAGEGKTKLSVNDFIVKASALALAEVPEANSSWMGESIRKYSRADICVAVATPNGLITPIIKDVGSKGLATISAETKSLATRARDGKLKPEEYQGGTFTISNLGMFGVNEFNAIINPPQSCILAIGTTTQKLELAPEEAKGFKAVSVMKATLSSDHRTVDGAVAARWMKAFKEYMEQPLTFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQM4</accession>
    <name>A0A1Y1UQM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874074.1">
        <property type="nucleotide sequence ID" value="XM_022014894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQM4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQM4"/>
    <dbReference type="GeneID" id="33556702"/>
    <dbReference type="InParanoid" id="A0A1Y1UQM4"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="560"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="800" mass="87283" checksum="6756F56AB197F760" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR37</accession>
    <name>A0A1Y1UR37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_575934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873681.1">
        <property type="nucleotide sequence ID" value="XM_022013157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR37"/>
    <dbReference type="FunCoup" id="A0A1Y1UR37">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR37"/>
    <dbReference type="GeneID" id="33554965"/>
    <dbReference type="InParanoid" id="A0A1Y1UR37"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="411" mass="46528" checksum="35C97800339C6234" modified="2017-08-30" version="1">MVSESQRPPLYTIPIDQRPPHGPLFSKVFFPLVFNVAQICINSTHFLALPLLLIPFGIGRRWFRNVIDYTKDGYGRLIILITVLFGPTTFVITSDAPVSNLVEHDDHGRLIRLVLPDRLVIVGNHQTYLDWMYIWILACYSGNASGIIILLKASLKKVPVVGWGMRFFRFIFLERSWAADKANLTRALQNLAKQARLNTPDETTGLVRSRREPLWLLIFPEGTITSDEERAKSVRYAKKEGVDDFKTLLHPRSTGLLFCLRTLLPEIPDLQMLDLTIGYPGVPYGKYPQEWYGLASTFFRSVPPPTVHIHMHLYSDLASPSGPIPSLHGESAEIPPSESRDFELWMRKLWTDKEKRMEGFYRDQHFEGSEALSVPVRQLKWYHNIAAFGAGGIVSVGAIAAVAYGIAKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URD2</accession>
    <name>A0A1Y1URD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_575940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873791.1">
        <property type="nucleotide sequence ID" value="XM_022013159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URD2"/>
    <dbReference type="FunCoup" id="A0A1Y1URD2">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URD2"/>
    <dbReference type="GeneID" id="33554967"/>
    <dbReference type="InParanoid" id="A0A1Y1URD2"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="21306" checksum="71F36E89B3E076B0" modified="2017-08-30" version="1">MSSSGSLKRKVVVMGSPNVGKTSLTQQWIAPPTYNESYFPTIEATSHKIINFEGVEYDCEVIDSAGQDEYTLFPSKYAVGVHGYLLVYSINSRQSFEMIQTVHDKILDFAGVEKVPCVVVGQKVDLSGSERRVTFAEGEALAKKLHASFIESSAKDNKNVGKAFEVLLREMQKEYNPAPEKKKSSWWGWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URQ2</accession>
    <name>A0A1Y1URQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_640583</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874409.1">
        <property type="nucleotide sequence ID" value="XM_022017357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URQ2"/>
    <dbReference type="FunCoup" id="A0A1Y1URQ2">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URQ2"/>
    <dbReference type="GeneID" id="33559166"/>
    <dbReference type="InParanoid" id="A0A1Y1URQ2"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="290"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX40730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="332" mass="36414" checksum="E09A30E95DD44DBB" modified="2017-08-30" version="1">MTSVAPVVTFKKGPSRRPQQSRNRAPSPTADEGQASSEAGPSTSSVVRPSKKNVANPLVQGTKRRRELNENGEEGDAGLDDFDYKAEEGLSGAKGDVYATRSTEWDLEAGGEAKIDGKKIKLNEDGEIDDGLYHGAAGYLKTINKRTDVLDKKMQTGPIRATTSIRTVTLVDYQPDVCKDYKETGFCGYGDSCKFLHDRGDYLAGWQLDKLDPNGGVPQEEEEEIEEVPFACLICRKEFTEPVVTKCGHYFCMKCAIERFQKSPKCYACGASTSGIFNKAEKILAKLEAKNKRKKEERGIVDEDDDGGIEIGGDEEEEEEGERGDSPALSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US25</accession>
    <name>A0A1Y1US25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_270409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874051.1">
        <property type="nucleotide sequence ID" value="XM_022012338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US25"/>
    <dbReference type="GeneID" id="33554146"/>
    <dbReference type="InParanoid" id="A0A1Y1US25"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="509" mass="55371" checksum="0BD8B09C3F029096" modified="2017-08-30" version="1">MSGQQQSPSRPAVRRHSSQVRFSRGDRSPIGTLTSEESSQGDSGTLRGRAQAPSHTRGHSDFNDINTYPVASETSHSGYTNPYYNSEADETELDTRSQRDSAQSSETIVAADHNRGGLRDSYTSTPPRIQTRRATNPTNMVPPSDKRQDISTPPATMRGNGPMNLPTGGRPSMATPPAPAPYVEEMLSPKSMPSEWGSPASQWQPQPPSPSPARPPSALKQTSASPIPTGPPIPGSTAGFMGQGFRQFDQPGPIYAPPPFPPSTPAASHEPIAPQQGTDPGSEPRFSLREWQEYQQRQQWAQNVGRHDSDETLTGGYPVNTEKPSVPRGSEAMHLEPVGPNEQTGMRRRTTREVEGNDEVHHVKGGVFSQLLRLAGRSNTLKNRNMSIGASSQGTSGELPIMENLGIRSRANSFTSTIFPMDELEPDDPRVTGKKPKPKDPNWDDLAYVQTTGVVRKRKGSIQLHVAGETRVRFALADSRHSHPPTIHLEARKSIDGIWSAISSGRIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USE2</accession>
    <name>A0A1Y1USE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_616276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873890.1">
        <property type="nucleotide sequence ID" value="XM_022014818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USE2"/>
    <dbReference type="FunCoup" id="A0A1Y1USE2">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USE2"/>
    <dbReference type="GeneID" id="33556626"/>
    <dbReference type="InParanoid" id="A0A1Y1USE2"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="113"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="62692" checksum="B6D90887ED0C0365" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USG4</accession>
    <name>A0A1Y1USG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_612723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874647.1">
        <property type="nucleotide sequence ID" value="XM_022014429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USG4"/>
    <dbReference type="GeneID" id="33556237"/>
    <dbReference type="InParanoid" id="A0A1Y1USG4"/>
    <dbReference type="OrthoDB" id="2575467at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35871" checksum="6654A796C811083F" modified="2017-08-30" version="1">MSAQNPPQGVQPQAGPSTAYHGPVAPSIPAANLQALVLRLTHAIHDIDAFQNLLAAGAHNGTLPTWDNILERYTLLLSRVQALSTYIHRPPPQTATPHPTEPPSTDPILSKYLVHPLNPLAPVGTEQGDQINPIARDIFEWVLSTLPNPSLSAFETQLLAPGQRTDSQTAWMTMDELKGLSEQQANDLSKELRDRLMRESRRAEAMREEIERKEEEMDWEMRILEGDNDDDTIAEGQASAKTEAEGDAKPDVEGAKKEQEEDLFGDGEDDFVMMDGPATSTNKDAPKPTPKKPEEDPQERWRLADYITYMDTGRLPQVKVTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USG7</accession>
    <name>A0A1Y1USG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_647404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874153.1">
        <property type="nucleotide sequence ID" value="XM_022017650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USG7"/>
    <dbReference type="FunCoup" id="A0A1Y1USG7">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USG7"/>
    <dbReference type="GeneID" id="33559459"/>
    <dbReference type="InParanoid" id="A0A1Y1USG7"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="229"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="46794" checksum="2727D3D4A2CD181E" modified="2017-08-30" version="1">MVGLGIGARLSALRHPAICFKTIRQPSPSFGPCTRRQLSTSRSFQERLGKITPKRIAIPLGSSPGIVSDGTGPSLSIWRPIIFCLVLGGGAYAGAAIYTNAETDTWARRLGDGAWWRRGTSGRASDSEIFRAKRLDQAKEAQQTINTITSNITFLPKFLQTIILRTSVMILEGELNTPPATLVPLEIIGTMAFITLAWRGRRTEGFMRRWFLHRPVVFSTSAKKKWQESITLFTSILSHQTLPHLAFNCLALYSFGGAAYSFLSAPPPGTTPLLSSTYTPHFLAFLLAAGLTSSLASHLWTNLFRLPRLLRALANPARISSPQALAAHEAILPSLGASGAIYAAVTLTACAYPNSGVSLIFFPFFAIPIGMGVGGMVMLDVIGLIRGWKMFDHVAHLGGALFGVIYYSYGRQAWVWVRRTLGGERKPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USR5</accession>
    <name>A0A1Y1USR5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874742.1">
        <property type="nucleotide sequence ID" value="XM_022017751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USR5"/>
    <dbReference type="STRING" id="4999.A0A1Y1USR5"/>
    <dbReference type="GeneID" id="33559560"/>
    <dbReference type="InParanoid" id="A0A1Y1USR5"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="378" mass="41420" checksum="253463FF61AE29F2" modified="2017-08-30" version="1">MHEGPATSGSTSSSKTPSTSFTPPDWTPSSRYSRGSFIAFAGCLWRCEVDHTSSDGERGIPPNNLHLWTPFAPMFAPRPPNSANAEQPPSYGYPYYPAHQISSASAEEKHDEVFASDSEDDSGHWTVIDRGGSEDLVASRQATAMEEKHVAKSRPELEAELHGDRVWKSAGIGIWSFSLDPNEEQNKASVWREWNDRPSKDAWIKAARARTRVYNDALQTPKPVVMWKLVEGGESFPSDAIPVGHEADGQTLFAARSLYAGGLHLGKASHTMFKGSSISFAGKELITDTFEVLCGPRDPRTLQWKKYRHGEKAVVGNWQPVEGGREADGRALLISRAEHAHGLHPGKILVGDDHACLGYGGGEVWVRPFEVLAYSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USR7</accession>
    <name>A0A1Y1USR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_678454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874738.1">
        <property type="nucleotide sequence ID" value="XM_022018992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USR7"/>
    <dbReference type="GeneID" id="33560801"/>
    <dbReference type="InParanoid" id="A0A1Y1USR7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="104" mass="11837" checksum="BAF38D5EC1A3A31C" modified="2017-08-30" version="1" fragment="single">MPKLTFRFSLRRIHMSRPRMPRITITGMMSPSAHSPAVATAREKSSRGLSIRRRFAAPHLPTLVLRSKCSSITPSQVGSLMSVNSRPRVWTFARIEYCTMHFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USY1</accession>
    <name>A0A1Y1USY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_40998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874797.1">
        <property type="nucleotide sequence ID" value="XM_022012708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USY1"/>
    <dbReference type="STRING" id="4999.A0A1Y1USY1"/>
    <dbReference type="GeneID" id="33554516"/>
    <dbReference type="InParanoid" id="A0A1Y1USY1"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX41118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21166" checksum="E47563C7A28505A2" modified="2017-08-30" version="1">MSRLLGAYQSLLTNRPFMGNMLTSAVLFATGDIIAQQGIEKKGWKNHDVARTGRIIFWGGGLFAPAVTVWFRQLQKIPIQSKWGGAIVRTSLDQFLFAPVVVTGFFTVMTLLEGKDMNAVKQKWNAQFVPTLQANWGVFIPTQLINMAFVPLQYRLLVINAVNIPWNAYLSLQAAKKGPVEEIKEKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU05</accession>
    <name>A0A1Y1UU05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_612521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874585.1">
        <property type="nucleotide sequence ID" value="XM_022014401.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UU05"/>
    <dbReference type="GeneID" id="33556209"/>
    <dbReference type="InParanoid" id="A0A1Y1UU05"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="775"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1652" mass="177253" checksum="24CB0E34EDD339AF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU72</accession>
    <name>A0A1Y1UU72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874783.1">
        <property type="nucleotide sequence ID" value="XM_022017761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU72"/>
    <dbReference type="GeneID" id="33559570"/>
    <dbReference type="InParanoid" id="A0A1Y1UU72"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="779" mass="86059" checksum="098E461B3AF361D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUN8</accession>
    <name>A0A1Y1UUN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_678328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874594.1">
        <property type="nucleotide sequence ID" value="XM_022018985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUN8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUN8"/>
    <dbReference type="GeneID" id="33560794"/>
    <dbReference type="InParanoid" id="A0A1Y1UUN8"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013344954" description="SH3 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="54180" checksum="04EB16400870922E" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5E1</accession>
    <name>A0A1Y1U5E1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Thioredoxin-like [2Fe-2S] ferredoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_640352</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000030">
        <property type="protein sequence ID" value="ORX33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867616.1">
        <property type="nucleotide sequence ID" value="XM_022017342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5E1"/>
    <dbReference type="FunCoup" id="A0A1Y1U5E1">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5E1"/>
    <dbReference type="GeneID" id="33559151"/>
    <dbReference type="InParanoid" id="A0A1Y1U5E1"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="250" mass="27741" checksum="2AC699E7740A260F" modified="2017-08-30" version="1">MASVASLTRTGRSAVSRNLPARAFTTSLSARSDSLFVHRDTDYNNPDIPFEFDAENLKMAKEIIARYPPQYKKAAVMPILDLGQRQNKGWTSISVMNAVAKLLEMPKMRVYEVATFYTMYNREPVGKYFVQLCTTTPCKLGGCGSDIIQKTIEEKLGVHGGESTKDGKFTYIEVECLGACSNAPMMQINDDFYEDLTPESTVKILDALSKGERPKPGPQSKRYKSENSAGLTTLTGKPYGPGEFCQPEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U649</accession>
    <name>A0A1Y1U649_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_639621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867837.1">
        <property type="nucleotide sequence ID" value="XM_022017254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U649"/>
    <dbReference type="STRING" id="4999.A0A1Y1U649"/>
    <dbReference type="GeneID" id="33559063"/>
    <dbReference type="InParanoid" id="A0A1Y1U649"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24153" checksum="6AF324D551444A9A" modified="2017-08-30" version="1">MALPRSLSFQRLGSGPQVLEVYLCPTCPFSGKIARALSANVLPLITKGGKYEGRVSLIPRLYPQPFHYTAQFQCEALVWIGTKYPELYWDYFLQIYEHIEEFGNVPAQNMTPLQTREKLFSIAQTLLEKNGKLKGPASQVHASFMDSADAVKRKAGDEYAKAVEAMLKSGVKLGRQNGIHVTPTVLFDGIRDDFVSSSWGKEEWEDYLAKKMQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6E2</accession>
    <name>A0A1Y1U6E2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_584868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867922.1">
        <property type="nucleotide sequence ID" value="XM_022013713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6E2"/>
    <dbReference type="FunCoup" id="A0A1Y1U6E2">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6E2"/>
    <dbReference type="GeneID" id="33555521"/>
    <dbReference type="InParanoid" id="A0A1Y1U6E2"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="580" mass="62498" checksum="54DBA3376BF734E0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6G5</accession>
    <name>A0A1Y1U6G5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_218598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867927.1">
        <property type="nucleotide sequence ID" value="XM_022012205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33554013"/>
    <dbReference type="InParanoid" id="A0A1Y1U6G5"/>
    <dbReference type="OrthoDB" id="2575033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1455"/>
        </location>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33608.1"/>
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            <dbReference type="Proteomes" id="UP000193218"/>
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    <sequence length="1455" mass="157692" checksum="29EC2150524783EB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6W2</accession>
    <name>A0A1Y1U6W2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="9">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="9">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN2</name>
        <name evidence="12" type="ORF">BD324DRAFT_640333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="9"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="InParanoid" id="A0A1Y1U6W2"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="500"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1078"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="858"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="860"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="967"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1020"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33274.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121234" checksum="6C54F2815D2EE962" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U805</accession>
    <name>A0A1Y1U805_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868420.1">
        <property type="nucleotide sequence ID" value="XM_022016935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U805"/>
    <dbReference type="GeneID" id="33558744"/>
    <dbReference type="InParanoid" id="A0A1Y1U805"/>
    <dbReference type="OrthoDB" id="3641682at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892156" evidence="1">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="194" mass="20011" checksum="41D6718F8E2BDA60" modified="2017-08-30" version="1">MLSITSAPLLVSLIASVSASPIGEVQKRCSPDGEITLASTSNPVAGDGNPHQNYYHEQISDTVTCASGDCSVSVSDTVTLSYHSDVSLNNWISGGFDVAQSFSMGSDYACNAGANDEVCVWISFGTTAYTVGSRDTCGNIYDVGVLQSPNKNGQGSTFYCVTGKDCRTKGQGYWEGGCAGGPQGNCGNGQVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8C5</accession>
    <name>A0A1Y1U8C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_637413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868567.1">
        <property type="nucleotide sequence ID" value="XM_022017004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8C5"/>
    <dbReference type="GeneID" id="33558813"/>
    <dbReference type="InParanoid" id="A0A1Y1U8C5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="113" mass="12073" checksum="3D2AE304B2F791A1" modified="2017-08-30" version="1">MAATTTTTYRTRRSPMTLSIAAFLTLLSAHEAMHLSFVWIDPLNFPFPRFSSPRFSSGSPRSGSLSSIVSTTSVGTLNHFGSSLAISDGNPPMAVTTRASGTRSTLESLTMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8D0</accession>
    <name>A0A1Y1U8D0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868569.1">
        <property type="nucleotide sequence ID" value="XM_022017005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8D0"/>
    <dbReference type="GeneID" id="33558814"/>
    <dbReference type="InParanoid" id="A0A1Y1U8D0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="242" mass="26556" checksum="D0B56B9BE6B9026D" modified="2017-08-30" version="1">MSESAGTTDAIEDFSKNTYKSLEDLVAKRGGQSTDKFGTHCEDVRIGPDTTDPQDTAFVVQNSDIAGITEVISLTDTHSNRGLMIFGIHNYLPDKAKWYSVQHDFYTAVPDDGSVTLTGDYTAFEPSTFKINPPDFPARHLHQAYLMHDQNQRSASPIWILLSDGPSETVGGLRNVMLAKHLVDTVRSLSQSNDRQSSWPSNWPIAGEEYCAQHSNTEDGLTTQGSKAQEESVPHHAGGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8E1</accession>
    <name>A0A1Y1U8E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">BD324DRAFT_585178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8E1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8E1"/>
    <dbReference type="InParanoid" id="A0A1Y1U8E1"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000131">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="176" mass="19963" checksum="B6970E4CF0529B3A" modified="2017-08-30" version="1">MLSSPINFPKWIEENKHLLKPPVGNKCIFKGDNMLTMVVGGPNSRVDFHINTTEEWFYQYQGAMTLKVVDEGKMRDIIIGEGEMFLLPANTPHSPRRTANTIGVVIELIRPETEIDTMRWYCPSSSHSSTDLVVIKESTFHCKDIEVQIKSAIEEWVGDEEGRRCKKCGEVAPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8M2</accession>
    <name>A0A1Y1U8M2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_643383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868653.1">
        <property type="nucleotide sequence ID" value="XM_022017540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8M2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8M2"/>
    <dbReference type="GeneID" id="33559349"/>
    <dbReference type="InParanoid" id="A0A1Y1U8M2"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="4">
        <location>
            <begin position="28"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="38310" checksum="E04AEED94F2B5C98" modified="2017-08-30" version="1">MAIQPSPEAGPSTPPNGRLPNYKLCHSLSGHSRAVTACCFSADGSELISAGADGTVNIWDPKVGAHKSSFQAHRAGINDISLSPDSLYLATASDDNTILVFHTTSTSTARHPTPLRRLVGHTAPVLSVAFSPKSNLVVSGSIDESAIIWDVRGGRVLRTLPAHSDMVWTVGWDNEGGMVITGSADGLIRLWDASTGQCLKTLDNESNSPFSYAAFTPSSTFLLSSTLSSTIRIHNIYTSKVLKTLRAPGTLVSERFPCPVVIIPALEGSTPLDRPDKPDAPRLGYSVDSRAAWIGSGSENGKFVIWELSSRRVIQVLETPEPSTIPSPIVAVAASPDGRTIVTGHLEPEKVIRIWRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8W8</accession>
    <name>A0A1Y1U8W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_683437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868754.1">
        <property type="nucleotide sequence ID" value="XM_022019185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8W8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8W8"/>
    <dbReference type="GeneID" id="33560994"/>
    <dbReference type="InParanoid" id="A0A1Y1U8W8"/>
    <dbReference type="OrthoDB" id="3345311at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="87"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="289" mass="32553" checksum="80626AE7343CBF28" modified="2017-08-30" version="1">MDSDLEGQLSQEDVTRILTYLDLPQSAGLPLAPLNFLRAHLAQLPYELALPFAKITTPRQRSSIKSIKSRRLIYASSEPKPLELTAERGRLRWPLLWERMGGSSLPPPSVNVDEEESWVEQNFLPGRENAQHVKKLGGFLRSLEEEREMMEVVAARRVERRLDDVGEEFDEESDEEEGTTNAPGISSVPGPNANTMVPPGIVVQINQQEQEDVRRAFEKHLTELFVDGLDTVDYTRIDFAEPPGGDVTAERDQEDAYFAEQEPSDAVDRTEPARSVSMPNQNGQGEYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U914</accession>
    <name>A0A1Y1U914_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_189002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868284.1">
        <property type="nucleotide sequence ID" value="XM_022012132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U914"/>
    <dbReference type="STRING" id="4999.A0A1Y1U914"/>
    <dbReference type="GeneID" id="33553940"/>
    <dbReference type="InParanoid" id="A0A1Y1U914"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="30741" checksum="A9AEFEC758AA0BB8" modified="2017-08-30" version="1">MEEGRGRQPLVSTGRGGAGNLLRSPSRGVDPEVRVGDERGREVRRDMSVERVIHSGRGGAGNIRSPSRDTRDRGTEDREDALQARLIAEERGRAHGGISTGRGGVGNIAGRDKSRSRSAVRDVADTDSTTPGRKGGASEVHASGRGGWGNINEERDSLDEEKLAAQEKHDAEIRSKHQADEVGKRIASGRGGGGNISAASPRPSDQTKEQQEEQAAHAKVHAQDKLRGVNTGRGGAGNIHREANGDHERGRNKVNGGGGGGGSVLGNVFRSLSRAARGDRGNERSSERAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U929</accession>
    <name>A0A1Y1U929_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle, SRP19 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_638000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868295.1">
        <property type="nucleotide sequence ID" value="XM_022017068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U929"/>
    <dbReference type="STRING" id="4999.A0A1Y1U929"/>
    <dbReference type="GeneID" id="33558877"/>
    <dbReference type="InParanoid" id="A0A1Y1U929"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39887" checksum="78EC085ACF091410" modified="2017-08-30" version="1">MPTIEDYFDDDTDLPLPSSSTARHLPNTGRHGALIREVDDDGSSEEELDMSTVAEQSRGVFGENVKAPPPSSTGKGKMTMREEPSSPVRQDGGMPDINPNTPMGGFMGDMMKLEKAEQERMEKLRKQFGNTTMAMDPSEYKGWNTVYPLYFDAKRSVQQGRRVPRKDSMWWPQAAQIAKCCRILGLPSVLEPDHCHPADWENPGRVKIRIMKDGRFFNPIVKNRTQLYRQLASQIRQQNPDYAYEPKPKREPKEKKETKVTSTPKPKSKSKATGNARPPPPKLPSRAPLAPQPFPDLESRLPLHSPVHSTGVAVSAVKRDLENEKENKKKGITAEEGGKEKAPKMKRVVVRGPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U987</accession>
    <name>A0A1Y1U987_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_636546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868854.1">
        <property type="nucleotide sequence ID" value="XM_022016906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U987"/>
    <dbReference type="STRING" id="4999.A0A1Y1U987"/>
    <dbReference type="GeneID" id="33558715"/>
    <dbReference type="InParanoid" id="A0A1Y1U987"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="250" mass="27718" checksum="EE845E37E7055574" modified="2017-08-30" version="1">MPQIKYLLFDCDNTLVLSEPLAFESCTELGNLILKQHLPADPAPFQYTESELQEEFVGLNFRGLVTTLGQKHGFEVPPTELDDWVSRELESTTSKLAARAVPCEGVMEVLDKLQSEHKYGLAVVSSSAMSRVQAALKKTDQTKYFGDRVFSAASMEPPTSKPDPAVYLHACEKLGVKPEECVAIEDSKSGATAAMRAGIHVLGYVGPYYDDGGIEKVKQMEKTLTQDCKAEGVMHHWKDFEDWIRKIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9D6</accession>
    <name>A0A1Y1U9D6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868015.1">
        <property type="nucleotide sequence ID" value="XM_022013702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9D6"/>
    <dbReference type="FunCoup" id="A0A1Y1U9D6">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9D6"/>
    <dbReference type="GeneID" id="33555510"/>
    <dbReference type="InParanoid" id="A0A1Y1U9D6"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="221" mass="24432" checksum="F8253BDE09DE5DDA" modified="2017-08-30" version="1">MSSWMGFWGSRKNSREATKDAIVGLRQQVLMLEKREEFLQKKIDEELKKARANATSNKRLATAALRQKKAHENELDRIAGTRLQLETQANALESANLNAETMVAMKTGADALKGIHSTLKVEKVDQTMDAIREQMDHANEISEAISNPVGMAGQYDEDELNAELEALEQEELDDRLAGAERAPIHAPVSPTGVHTGPTITATAEEDDEEAQLRQLQAELAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9J7</accession>
    <name>A0A1Y1U9J7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_634550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868943.1">
        <property type="nucleotide sequence ID" value="XM_022016742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9J7"/>
    <dbReference type="GeneID" id="33558551"/>
    <dbReference type="InParanoid" id="A0A1Y1U9J7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="89" mass="9168" checksum="A8A11930D4CE50BE" modified="2017-08-30" version="1" fragment="single">MALRTFGTIAADPSFFLSRVSLIVMITVESNCTAVFGPPALDQYAMAETGFFVAASLFGQASGGSAFLALGTVGVLVVDLDAIGRVYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAM8</accession>
    <name>A0A1Y1UAM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_633833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869295.1">
        <property type="nucleotide sequence ID" value="XM_022016666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAM8"/>
    <dbReference type="GeneID" id="33558475"/>
    <dbReference type="InParanoid" id="A0A1Y1UAM8"/>
    <dbReference type="OrthoDB" id="2751476at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="311" mass="33113" checksum="862B2FA842F1762E" modified="2017-08-30" version="1">MSQPSTTTATGADPASLPPLPTDHLSHPDQWATGAEPATDKQKGFIKVLEKQHPENVPEGGVDVEIMQKGEASEVIQKLKEGQSLGDEEEKPAGEVEKKNGVTHGEEVQTKQNDSAATGERPVPDVVEQKQTDAHVASSLEEAEAVSPAADKSAKSFEQVVSEQGAKKAEANAQPPSSSLPPPSSSQTSSSEKVDFSGVDKNPTKQATLDDMMGGKAKAERDDKTIKSEEIKEAEAKTHEEIKDGQEKDETVSNGQGDSVKGTNGHVEKQNGHSSTVWESDGSEPRAKRKEQDKVSGDEDVQSSKKVKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB03</accession>
    <name>A0A1Y1UB03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_631855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869408.1">
        <property type="nucleotide sequence ID" value="XM_022016472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB03"/>
    <dbReference type="FunCoup" id="A0A1Y1UB03">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB03"/>
    <dbReference type="GeneID" id="33558281"/>
    <dbReference type="InParanoid" id="A0A1Y1UB03"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="612"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="752" mass="81792" checksum="60A376AF044BDA14" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB55</accession>
    <name>A0A1Y1UB55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868593.1">
        <property type="nucleotide sequence ID" value="XM_022017017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB55"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB55"/>
    <dbReference type="GeneID" id="33558826"/>
    <dbReference type="InParanoid" id="A0A1Y1UB55"/>
    <dbReference type="OrthoDB" id="2896281at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="214" mass="24620" checksum="A0C98C14C7ABF419" modified="2017-08-30" version="1">MDGLTILSVVDEDLPRLAEISFHARQDNPLTRAKWPEEISMDPKTRKDNFTSRFIFDYSSSRSTYLKATLNSEIIGFIVWDDPQDPKVHRINDCISHEQYLRGADMTLLRSMGARHNEAESEVDSPHQYLSDINVAKEAQGKGVGSQLLDWGLRLAQRRRQPVFCLSSDEGFRLYSKRGFEVVRWVEFQTSSGDIIKERVLWKPCKPSQEEDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBA8</accession>
    <name>A0A1Y1UBA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869513.1">
        <property type="nucleotide sequence ID" value="XM_022016515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBA8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBA8"/>
    <dbReference type="GeneID" id="33558324"/>
    <dbReference type="InParanoid" id="A0A1Y1UBA8"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28502" checksum="7BBC9FB81376A7A8" modified="2017-08-30" version="1">MTYLTEHLTFGPSTSSNENAGALPGPGSHLVISDCLASPATFTLYHLLQAAIGRRLPVIFIDIRGEGKKSLEAVLRRLGTAMPKSSEIFSYISPVSFPSTNVEAPEPCLFDEEGRHDLKPLYARIASRISDQDTLVILHGLSDIMSMGIPTQDVHRFVRAVDAAVRKASCILVTTLHADGLAEGSLTNDQVLLEKLLRSATAWWRVEELQSGRSGDVHGEISSHPLATNGNETSVPKSHPLQYRLEMNTVKVFAKGTGRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBD3</accession>
    <name>A0A1Y1UBD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_635198</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869069.1">
        <property type="nucleotide sequence ID" value="XM_022016795.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBD3"/>
    <dbReference type="GeneID" id="33558604"/>
    <dbReference type="InParanoid" id="A0A1Y1UBD3"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1483"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="818"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="958"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1538"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1619"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
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        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="837"/>
            <end position="872"/>
        </location>
    </feature>
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        <location>
            <begin position="881"/>
            <end position="894"/>
        </location>
    </feature>
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        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1539"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1650"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1672"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1690"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1703"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1721"/>
            <end position="1731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1800" mass="193424" checksum="E042509D40A44C19" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBV3</accession>
    <name>A0A1Y1UBV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_652074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869685.1">
        <property type="nucleotide sequence ID" value="XM_022018434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBV3"/>
    <dbReference type="GeneID" id="33560243"/>
    <dbReference type="InParanoid" id="A0A1Y1UBV3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="348" mass="38601" checksum="CA19C00AA1991789" modified="2017-08-30" version="1">MESSIPLTELPRWMKWLLNQRPDLAGIPITALIVPGTHDTATYGEGTSPTKLGRFNWQCQNLNIYQQAQIGVRYFDLRFLADDRDSAFPYWPHHGDAVRTGDLLAPALGGDISQTTIVGQITRFLAENPDEIIILSCDVQPADNIHWPRALCDALGGTGRLVESPDWATATDNPYPPVRAAVPTIGGVLKTTGRVILSGSVDLRMFSDHDERRLVERYVWQSPGAAIFSSLYDEPIWKSNQPVNIQTAIENWIHANDTAISHRAHFYNAQCQLTPSANNFWDVLKGLTDKSMSISPAKLAPGMNSYLREKVCTSDLWIKKASIMTIDFADAETCTAIVNMNLARFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC35</accession>
    <name>A0A1Y1UC35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_634330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868887.1">
        <property type="nucleotide sequence ID" value="XM_022016714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC35"/>
    <dbReference type="FunCoup" id="A0A1Y1UC35">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC35"/>
    <dbReference type="GeneID" id="33558523"/>
    <dbReference type="InParanoid" id="A0A1Y1UC35"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="28170" checksum="3E8A67ABCBC06ED5" modified="2017-08-30" version="1">MRPTLPSLIHILVPVKRSIDYAVKIRVASDQKGVDTSVKHSMNPFDEIAVEEAIKLRERSKELVESITAVSIGPAKSVDTIRTALAMGADTGIHITTPENVTVEPVSVAHALKAVVEKNKYDLIIMGKQAIDDDSGSTGGMLAGMLGWSQASFASKLEVESSGAVKVTREIDGGLEKLETKLPVIVTTDLRLNEPRFATLPNIMKAKKKKIESFKPEDLGLDFKPRMETISVSEPPVRQGGQKVESVDELISRMKSAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCB9</accession>
    <name>A0A1Y1UCB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trafficking protein particle complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_634700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868967.1">
        <property type="nucleotide sequence ID" value="XM_022016751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCB9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCB9"/>
    <dbReference type="GeneID" id="33558560"/>
    <dbReference type="InParanoid" id="A0A1Y1UCB9"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="707"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1151" mass="127899" checksum="F0CB6B8C8657B875" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCF3</accession>
    <name>A0A1Y1UCF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_73851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869892.1">
        <property type="nucleotide sequence ID" value="XM_022019231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCF3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCF3"/>
    <dbReference type="GeneID" id="33561040"/>
    <dbReference type="InParanoid" id="A0A1Y1UCF3"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="477" mass="52535" checksum="D74BD323A180090B" modified="2017-08-30" version="1">MSRTAYIWSTELQTVADQLPANVGRSSMVHGLIHALDLLEDRHHDGARSGAQQNAEQIDADAEVEQDEDEYEDQEREEKPIAAPIPSLSGRATIVSPYERFASETELKRYHDAAYVDYLLGDHSPAAAAAAAESDSDTGASSSSRPRKRMKSDVHGLHYDCPPFPSLSRYATLVAASTLTACDLIANDLTDVAINWDGGRHHAMRNRASGFCYVADAVLGILHLVKTGRSKRRKGRPRVMYLDLDFHYGDGVAQAFLSPTAYPVVIPDGRKPPRPPQVLTLSVHHSAPDFFPPGNKHSKLTEGNTPHPFTLSIPLKSFPSASTYERVWGSIESVRMAFEPDYVVIQLGTDGLPGDRIGQYGNWSIDQPGGIRCCIDRVKSWNLPLCVLGGGGYHHPNTARAWAVATAALIDKELPLQSSIPDHEYFPDYSPSFTFELSQAHVRDENDSQHLEAVNQVFSTISERIGDIVRAHTPKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCM1</accession>
    <name>A0A1Y1UCM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_631710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869957.1">
        <property type="nucleotide sequence ID" value="XM_022016456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCM1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCM1"/>
    <dbReference type="GeneID" id="33558265"/>
    <dbReference type="InParanoid" id="A0A1Y1UCM1"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="189" mass="21107" checksum="11B687E5C32B1DDF" modified="2017-08-30" version="1">MPPPPDTREDASGSRTMTIEATQQPESGPSEPHHRALDSNHTVGVLKLRGAPVRKQRVMWTDETVDNEGMGKKKSKICCIYHRPKAYDESSTESDSSCSEGESHSHQRRQRTSGKQASRRKRRDVVEVEQSTSSESEGGHGDGRAKSSKRSPRRHHAHDHGDHDHPSHSHKPNKYDHQEKPSSSDAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCM7</accession>
    <name>A0A1Y1UCM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869446.1">
        <property type="nucleotide sequence ID" value="XM_022016485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCM7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCM7"/>
    <dbReference type="GeneID" id="33558294"/>
    <dbReference type="InParanoid" id="A0A1Y1UCM7"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="3">
        <location>
            <begin position="97"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="767" mass="81777" checksum="83466AFD0B7901B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCR9</accession>
    <name>A0A1Y1UCR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_632306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869504.1">
        <property type="nucleotide sequence ID" value="XM_022016508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCR9"/>
    <dbReference type="GeneID" id="33558317"/>
    <dbReference type="InParanoid" id="A0A1Y1UCR9"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39252" checksum="4D6578B5DB509C69" modified="2017-08-30" version="1">MSAGSSSTMTQTLLDGQFPSEEFMSGVLRLRGSHLTPSTTAFPELDKNGYTVVKGVISREKAAQYVQRMYQWLESFGTGFKANDRSTWHINKVIPFNKGGLFSRYGAGHEQYAWDIRAEPELIKVFAKIWGTEELLVSYDASNISLPYPAEEMEGDVSAPWPHVDQSPNRRFKHCVQGIMNLEENGPNDGGLMVLTGSLPLYNEFFETHEHLQPEGGWSWKDSYPFTEADMQWFYDRGCKWIKVEAEPGDVILWDSRCVHYGAAARGDRPRVATYVCYKPAAEITPEMKEARKIATEQLIGTSHDPLLFRMTGTKILGDAIPNERREPLVRPVLTERMQQLAGVKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD27</accession>
    <name>A0A1Y1UD27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_629658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870087.1">
        <property type="nucleotide sequence ID" value="XM_022016239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD27"/>
    <dbReference type="GeneID" id="33558048"/>
    <dbReference type="InParanoid" id="A0A1Y1UD27"/>
    <dbReference type="OrthoDB" id="2564793at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="852" mass="92242" checksum="89EE9508FD19152A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD64</accession>
    <name>A0A1Y1UD64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_629804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870127.1">
        <property type="nucleotide sequence ID" value="XM_022016259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD64"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD64"/>
    <dbReference type="GeneID" id="33558068"/>
    <dbReference type="InParanoid" id="A0A1Y1UD64"/>
    <dbReference type="OrthoDB" id="2576496at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37432" checksum="3DE6B873F25986CF" modified="2017-08-30" version="1">MLIFIEMMSTCSVNGKGVIRHLTDPKSATSIASLATWANLVLVAPLVRSTGSGRCSCPDCLFEGPHFDDLMAHISRRHPDATPDDFVPGLIHHRPLRLPRSVSDLPPLPSRARITGEFMDDLCGEVKGFAGERSYKARRSVERNCFSGRRPRKDDFADKKGANAAISAFIENSRRISTAMGGQQESPAEADAADVPPTAKSAPLTAAEAKEMGVDLVDVSQSISAATEQAKREAEKDEAQTTGSDSRSSSTSRADIEPVKRKRGRPPKLHVTLKLSESPAERFSLESPPSTSSESSSGSETASEFKLKRALDLTALVSPDGGESGRKRSARLREKQGLGTFDEEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD72</accession>
    <name>A0A1Y1UD72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_629791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870120.1">
        <property type="nucleotide sequence ID" value="XM_022016256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD72"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD72"/>
    <dbReference type="GeneID" id="33558065"/>
    <dbReference type="InParanoid" id="A0A1Y1UD72"/>
    <dbReference type="OrthoDB" id="3358078at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="985" mass="107204" checksum="05D9332F15742591" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD96</accession>
    <name>A0A1Y1UD96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_581569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870121.1">
        <property type="nucleotide sequence ID" value="XM_022013513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD96"/>
    <dbReference type="FunCoup" id="A0A1Y1UD96">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD96"/>
    <dbReference type="GeneID" id="33555321"/>
    <dbReference type="InParanoid" id="A0A1Y1UD96"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="157"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="50859" checksum="AC85DDF61B74A7D8" modified="2017-08-30" version="1">MGDPDNPLSTARPRATPTSIPPLSRPGSSTPSSSFPSLKQSSVSRKKPEGLSITRSIRPAPSPPTDGSPALTGKKGSIGWVSETDRLRQDIERLQLSSKSSSSLDSPESSSPTAPTTPTHLAQSDSSSSSRSKKSSSSKAKRTKDKNGDDLVKDEDLDIMQDLGAGNGGTVTKVWNKKRKCIMARKLILVDAKPSVRKQILRELQIMNDCSSPYIVGYYGCFPVDVHVGIVMEYMDATSLDHIYRNTGPVPIDMVGKVAEAVLRGLMYLYDVHRIIHRDIKPSNILANTAGDIKICDFGVSGELINSIANTFVGTSTYMSPERIQGAPYTIKSDVWSLGISLIELAHGRFPFSDSADEALDFDPDPTLSASTQRPTLSNKPGNPRGGARAMSILDLLQHIVNEPAPKLGTSRRDFPSEAVEFVRGCLDKDPSIRQSPQELLKSKWIVDSQVTKDQLKAWTRQVAPSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDE1</accession>
    <name>A0A1Y1UDE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_629805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870128.1">
        <property type="nucleotide sequence ID" value="XM_022016260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDE1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDE1"/>
    <dbReference type="GeneID" id="33558069"/>
    <dbReference type="InParanoid" id="A0A1Y1UDE1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="616" mass="68056" checksum="1287BDFE4D2092AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDH8</accession>
    <name>A0A1Y1UDH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_652157</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869771.1">
        <property type="nucleotide sequence ID" value="XM_022018447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDH8"/>
    <dbReference type="FunCoup" id="A0A1Y1UDH8">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDH8"/>
    <dbReference type="GeneID" id="33560256"/>
    <dbReference type="InParanoid" id="A0A1Y1UDH8"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000017">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="483" mass="51986" checksum="29669C30D1C1DB3F" modified="2017-08-30" version="1">MTRTKSYAEAISLLNTCQSNAAAIEAVRKSGGRLQELGIPEMLDYLRRIGYKPDDLNALNVIHVTGTKGKGSTSAFAERIVRSHLPSSSKVGLYTSPHLCAVRERIRINGEPLSEEVFAKYFFEVWERLENDPKTLTPTTPVFPIYFRLLTLLAFHTFLSLGVDATVLEVGIGGTYDSTNIVPKPITTGVSSLGMDHTAILGNTIEEIARNKAGIYKLGVPALSVPQDRAGQVLENYANEIHAPFQVVPIIPETSLGIRGDHQRINASLAVGLAKSFLASPQGGNQTFSEILPESFVKPLAETKWPGRCQRVPRGKVTWLLDGAHTTESLTSCGEWAWSEAKPTALIFNCSGGRASDQLLGSLLQAGASKCGQSKEELGSTLDTVIFCTNVTYTSGAFKGDLTSNAIDPNDLSQLATQHALRDAWLALNPCFPPEQVHVVASIEHAVNIINSQNKAEVLVAGSLHLVGGVMEVAGLQDALGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDJ0</accession>
    <name>A0A1Y1UDJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_630789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869758.1">
        <property type="nucleotide sequence ID" value="XM_022016365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDJ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UDJ0">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDJ0"/>
    <dbReference type="GeneID" id="33558174"/>
    <dbReference type="InParanoid" id="A0A1Y1UDJ0"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="257"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="338" mass="36662" checksum="E212DDF8E68E7CE4" modified="2017-08-30" version="1">MAGDKSQLLEMGFEEARVNWALRATKNAGLQPAMDHILANMDNDVPEAGGPEGEEDGLSGSGEDLVARSIKCSDCGKIFRSQNSASLHAEKSGHENFEESTEEVCVLHSSAHDGSLSADYAAFPDAVQIKPLTDEEKKAKIEELRAKLAEKRATQSKEDAKEAKANEKIRRKAGQDFGKIKEDLEVKEIAKDVERRKAEKLADQKARAAIKAQIEADKKERAEKAAREKAARAGQSSTDSPAVQQPLAKPSAAVKSSDNPDTRLQIRLSVGGQPLTKTFPSDNTLIDVAEFVASENLAYDVSTVTFASTFPRKTYSRDEMSKTLKENGLTPSAVLMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDY5</accession>
    <name>A0A1Y1UDY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870361.1">
        <property type="nucleotide sequence ID" value="XM_022018345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDY5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDY5"/>
    <dbReference type="GeneID" id="33560154"/>
    <dbReference type="InParanoid" id="A0A1Y1UDY5"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF132">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="514" mass="56394" checksum="3999D41EF74A79DB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDY9</accession>
    <name>A0A1Y1UDY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_627892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870310.1">
        <property type="nucleotide sequence ID" value="XM_022016057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDY9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDY9"/>
    <dbReference type="GeneID" id="33557866"/>
    <dbReference type="InParanoid" id="A0A1Y1UDY9"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="61585" checksum="7227B62BE057A057" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE02</accession>
    <name>A0A1Y1UE02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_74630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869900.1">
        <property type="nucleotide sequence ID" value="XM_022019233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE02"/>
    <dbReference type="GeneID" id="33561042"/>
    <dbReference type="InParanoid" id="A0A1Y1UE02"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="154" mass="16238" checksum="24690810AABCBC5E" modified="2017-08-30" version="1">MSTAVMMPAEATPLPSPQTHIDSTGATGCPIGVDTIHLSADKTTPIDEVPDASGDITMTAARPTEDADLQDQCALVAPTITTDGTSASKVDHPPLDNAHDPIAVVCGIAPLANSAPSHDQPLRQWLNQLSLQGPLYRLPRPRLNRSLRPPLSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE11</accession>
    <name>A0A1Y1UE11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_628150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870379.1">
        <property type="nucleotide sequence ID" value="XM_022016090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE11"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE11"/>
    <dbReference type="GeneID" id="33557899"/>
    <dbReference type="InParanoid" id="A0A1Y1UE11"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="312"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="596" mass="65265" checksum="43D6A8E1F5DD884E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE22</accession>
    <name>A0A1Y1UE22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_608980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870389.1">
        <property type="nucleotide sequence ID" value="XM_022014135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE22"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE22"/>
    <dbReference type="GeneID" id="33555943"/>
    <dbReference type="InParanoid" id="A0A1Y1UE22"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="290"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="353" mass="38271" checksum="17FAD0A488596B39" modified="2017-08-30" version="1">MATDYFSTDPIVAPQDSSSGRLGVSGSGGGGLTPGHPINGFLSPNFWLFQTASEGTHPNQSMTNLSSGSDTPMSVGGGTIETRNSSLSTTATQQSPFNSAVSIPGSTDQSPAIHPSQLESVNFTNPFHHHQPEGAASASSSSSSSVPQVGMKFDRPNAIHTSLLVSPRKRGKATSQSLPTLITTTQMETSMDSPESYEISTPDIKPVVHHIRPPLRSEANAVASSSSSSGQGHSRRTSTAKRRMSSMDSLMEEPDEVDSEHEQYEISEGVERDGMIWGMKVEDYRALTARERKRVRNRISARTFRAKRKEHLSSLETTLNAKETKLRLATDEAARLRKQVADLKKRLSKYEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE37</accession>
    <name>A0A1Y1UE37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_608976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870383.1">
        <property type="nucleotide sequence ID" value="XM_022014134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE37"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE37"/>
    <dbReference type="GeneID" id="33555942"/>
    <dbReference type="InParanoid" id="A0A1Y1UE37"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="32"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="570" mass="61555" checksum="6BE6CFF1469DFCA1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEL2</accession>
    <name>A0A1Y1UEL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_629077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870601.1">
        <property type="nucleotide sequence ID" value="XM_022016172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEL2"/>
    <dbReference type="FunCoup" id="A0A1Y1UEL2">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEL2"/>
    <dbReference type="GeneID" id="33557981"/>
    <dbReference type="InParanoid" id="A0A1Y1UEL2"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="447"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="644" mass="69633" checksum="6B24931F3B95462F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEY5</accession>
    <name>A0A1Y1UEY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_642750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870203.1">
        <property type="nucleotide sequence ID" value="XM_022017502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEY5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEY5"/>
    <dbReference type="GeneID" id="33559311"/>
    <dbReference type="InParanoid" id="A0A1Y1UEY5"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="771"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="842"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="109"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="399"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="636"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="105060" checksum="760D65B80717A2FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEZ4</accession>
    <name>A0A1Y1UEZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L1p/L10e family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870236.1">
        <property type="nucleotide sequence ID" value="XM_022016305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEZ4"/>
    <dbReference type="FunCoup" id="A0A1Y1UEZ4">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEZ4"/>
    <dbReference type="GeneID" id="33558114"/>
    <dbReference type="InParanoid" id="A0A1Y1UEZ4"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="352" mass="38405" checksum="6EF5DBDA505E1A14" modified="2017-08-30" version="1">MPPKSKPASVEASSSKVQAPLPDSFSQKQAKKAVDALLAHHEKVVSEREETELIPREDHIWLIVNTKRGNTKRKLMPKRVQLPHPPLPPPPITAVGLIVKPPQRTYKDLLVSPEHNIRFINRVVDTDKLRGKWKPFEARRNLAKENDLWLADERIVPSLPKLLGKTFFDAKKVPIPVNLKRKDLKAELGRAISSTYFHPSTGTSHSVRIATPPSSTSAQTLENFLAALPVVIGLIEDGWDNVLSVGIKTSSSILLPVWNSPLADRFKGKTTEENETPEPAVKSEKKRKIDAGESSTKKAKADPLVAAASKPVKTTETSSKADKIVKKAGKKSSSVGTGGTGKKAKTAILGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFA6</accession>
    <name>A0A1Y1UFA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_459889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870738.1">
        <property type="nucleotide sequence ID" value="XM_022012844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFA6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFA6"/>
    <dbReference type="GeneID" id="33554652"/>
    <dbReference type="InParanoid" id="A0A1Y1UFA6"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="831"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
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            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="694"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="751"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="950"/>
            <end position="1015"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="134"/>
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        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="278"/>
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            <begin position="294"/>
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            <begin position="330"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="767"/>
            <end position="786"/>
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    </feature>
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        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1015" mass="107646" checksum="9EA15D4FA4334656" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFB3</accession>
    <name>A0A1Y1UFB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor IIIC subunit delta N-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018284.1"/>
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    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTF3C4"/>
    </dbReference>
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        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
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        <property type="entry name" value="TFIIIC_Znf"/>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="697"/>
            <end position="754"/>
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            <begin position="88"/>
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    </feature>
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            <end position="790"/>
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    </feature>
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        <location>
            <begin position="850"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="866" mass="94414" checksum="81BC73337AF99180" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFP6</accession>
    <name>A0A1Y1UFP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N1221-like protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018323.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFP6"/>
    <dbReference type="GeneID" id="33560132"/>
    <dbReference type="InParanoid" id="A0A1Y1UFP6"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="146"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="563"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150771" checksum="36B6FCEB742C171F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG74</accession>
    <name>A0A1Y1UG74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_422240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871066.1">
        <property type="nucleotide sequence ID" value="XM_022012733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG74"/>
    <dbReference type="GeneID" id="33554541"/>
    <dbReference type="InParanoid" id="A0A1Y1UG74"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="917" mass="104149" checksum="AF75C34F3604D5C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG89</accession>
    <name>A0A1Y1UG89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_505681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870627.1">
        <property type="nucleotide sequence ID" value="XM_022012956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG89"/>
    <dbReference type="GeneID" id="33554764"/>
    <dbReference type="InParanoid" id="A0A1Y1UG89"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="143" mass="16506" checksum="12F7A77457864D5E" modified="2017-08-30" version="1">MAGGRRLKFSFVCLRVCFWREGVPREREQLKRDCRANCGSFGLECIDASVSGRTVYRVYKGDLYDSQNTSVLRDTRREKHRGSRYHRQDQMNRWIVAGKSLSRHLISGREPVQLGLPICTDRLKGRAVHENGALQLFYGSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG91</accession>
    <name>A0A1Y1UG91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870204.1">
        <property type="nucleotide sequence ID" value="XM_022016289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG91"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG91"/>
    <dbReference type="GeneID" id="33558098"/>
    <dbReference type="InParanoid" id="A0A1Y1UG91"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="791" mass="87478" checksum="7578C32BB061D48C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGD9</accession>
    <name>A0A1Y1UGD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_455163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870666.1">
        <property type="nucleotide sequence ID" value="XM_022012828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGD9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGD9"/>
    <dbReference type="GeneID" id="33554636"/>
    <dbReference type="InParanoid" id="A0A1Y1UGD9"/>
    <dbReference type="OrthoDB" id="205569at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="425" mass="45864" checksum="F5BDF17D6BF2DE2F" modified="2017-08-30" version="1">MAKKSANPVDAFRKAQRAKELKKNKEIRKKSRESQAVKQDTRELESEIKQLKSKLGANAQTRLADLEKELAKINKIKENYVAEHPEARDRVFRTHERSAPKRDEATQEVHNELYDDSGRLRDPTRSIYYDPVYNPFGVPPPGMAYKERTPEIGADDSEDDSEEEDSDDEIVLPAGPPPGQDDSDSDDSDDIPLPSGPPPPRVNAPGLPSQLPIPFAGPPISMGFGVSPPFPPQTGFRPEPPAPSFPHNARHRPPPNVQDPLSDGPTQTYQGYRMAKHDLPARPSDPAGPSSSSAGIISSAPQINIAAAGQSKESASANAGSGEISAAPVMRDLRKEATAFVPRGVKRKKEIGGMTVNAAPGSGMLDADGDEIRVKREEVGGGLLGKLKGVLSNGQQSSVSPPKSKTNARVDDDYQKFLDGLGDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGI8</accession>
    <name>A0A1Y1UGI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_566417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871180.1">
        <property type="nucleotide sequence ID" value="XM_022013038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGI8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGI8"/>
    <dbReference type="GeneID" id="33554846"/>
    <dbReference type="InParanoid" id="A0A1Y1UGI8"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="67" mass="7758" checksum="1D467DAA3A4E790E" modified="2017-08-30" version="1" fragment="single">CSICNRDPPKYTCPRCSYRTCSLTCSKAHKAKFECSGERDPTGYIPLKDVNHGIWADDYKWLEEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGS4</accession>
    <name>A0A1Y1UGS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871260.1">
        <property type="nucleotide sequence ID" value="XM_022018213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGS4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGS4"/>
    <dbReference type="GeneID" id="33560022"/>
    <dbReference type="InParanoid" id="A0A1Y1UGS4"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="324"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="687" mass="75103" checksum="4218AA2C2F147DF5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHC9</accession>
    <name>A0A1Y1UHC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_627602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870965.1">
        <property type="nucleotide sequence ID" value="XM_022016017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHC9"/>
    <dbReference type="FunCoup" id="A0A1Y1UHC9">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHC9"/>
    <dbReference type="GeneID" id="33557826"/>
    <dbReference type="InParanoid" id="A0A1Y1UHC9"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="279" mass="30610" checksum="131254101FEC3A83" modified="2017-08-30" version="1">MNFFNGLSQNATRLLIGAAVGTAVVQSAIYDVPGGYRAVLFDRFSGVKPTASGEGTHFLIPWLQRSILYDVRIKPRNISTTTGSKDMQMVSLTLRVMSRPDMNQLPKIYQNLGLDYDERVLPSIGNEVLKATVAQFDASELITNREIVSARIRDDLLNRAREFGIMLEDVSITHMTFGPEFTRAVEQKQIAQQDAERAKFVVEKAEQERQAAVIRAEGEAEAAATISRALNKAGDAFVAFKKIESSREIAASLSGSRNVSYVPASSGNLLIQVPTTPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHI5</accession>
    <name>A0A1Y1UHI5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871500.1">
        <property type="nucleotide sequence ID" value="XM_022015448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHI5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHI5"/>
    <dbReference type="GeneID" id="33557257"/>
    <dbReference type="InParanoid" id="A0A1Y1UHI5"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="376" mass="42637" checksum="4A2901487FD04C6B" modified="2017-08-30" version="1">MGEHRAMLPRHIEASQISALLDSLGEPQPDHIEPLQVTAEYHAIFILSYRSPKADWILRVSGAHIPEIKTRNEVGMMKTISEKTTIPIPRVVHFDASTSNSLGHEYTILERASGISVDKVYDTLSELTKHALMQQLLEVLVQLDALQWNFIGGLAAQDDGSVVPGPVVDETFWQTSDIAEFWGPAESVETLNVQGPFTTFVDYCNAHLEKYIHMIKTHESMRWLRDLIPRLQATITMATDRAIALNDTRLILAHRDLHFANIMFDPETERISSVLDWEFSNIVPAARWNPAHAFLWNGQAGPRSLEEKARLYADFERQCKQRQILVDYKFTPLQEAIQQVVTYVRALTEVCPRAQQKDSVAGWRRSAEEALESLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHP9</accession>
    <name>A0A1Y1UHP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_622513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871568.1">
        <property type="nucleotide sequence ID" value="XM_022015481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UHP9">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHP9"/>
    <dbReference type="GeneID" id="33557290"/>
    <dbReference type="InParanoid" id="A0A1Y1UHP9"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="84"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="412" mass="43947" checksum="974B27DE71872E2D" modified="2017-08-30" version="1">MASRAASSLSRLSLRSTSSSSSPASTSLLHLPQSAKLSTSTSSKLISRNALASTPLARVSRAAPKYLVGQGQRAASSEQGGGTMTVREALNAAMEEEMLRDETVFILGEEVARYNGAYKVTKGLLDKFGEDRVIDTPITEAGFAGIAVGAALAGLRPVCEFMTWNFAMQAIDQIVNSGGKTYYMSGGNVPCPVVFRGPNGAAAGVAAQHSQDYCAWYGSVPGLKVVSPWSASDCKGLLKSAIRDPNPVCVLENELMYGVSFPMTKEEMSDDFLIPIGKAKVEKEGTDVTVVAHSKMVTHALEAAEKLEQEEGIKAEVINLRSIRPLDIETIVSSIKKTNHLVTVEGGFPAFGVGSEILAQVCESPAFDYLDAPPERITGADVPTPYALTLESLAFPDTPLIAKVLKRHLYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHQ0</accession>
    <name>A0A1Y1UHQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_622372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871539.1">
        <property type="nucleotide sequence ID" value="XM_022015469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHQ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UHQ0">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHQ0"/>
    <dbReference type="GeneID" id="33557278"/>
    <dbReference type="InParanoid" id="A0A1Y1UHQ0"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="14385" checksum="E324928CDEF5A4C8" modified="2017-08-30" version="1">MSNLSDDTLRRILQQIEGQAVSATRSLSVVRAQIQSRERERKILTLTQRELADVPGECKMYKGVGKMFVLQSRKDVDGTLSAQEKTVSEDLTNLAKKSKYLQKQADEANAQLNDIFRSQLRAQEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHX7</accession>
    <name>A0A1Y1UHX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_624784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871134.1">
        <property type="nucleotide sequence ID" value="XM_022015733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHX7"/>
    <dbReference type="FunCoup" id="A0A1Y1UHX7">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHX7"/>
    <dbReference type="GeneID" id="33557542"/>
    <dbReference type="InParanoid" id="A0A1Y1UHX7"/>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="107" mass="11741" checksum="ED353059FE1F3C4F" modified="2017-08-30" version="1">MSDAKATDSKADATTAGSLVEKKEEDGKKKLPQLGALEDDDEFEEFPASAEQSGNILDAMTKKDPNGPGDQLWEMNWDDDDVDDEFTKQLRTAIAERNGASDEAMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI00</accession>
    <name>A0A1Y1UI00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_622655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871606.1">
        <property type="nucleotide sequence ID" value="XM_022015495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI00"/>
    <dbReference type="GeneID" id="33557304"/>
    <dbReference type="InParanoid" id="A0A1Y1UI00"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="172" mass="18633" checksum="00C431ED53D047D3" modified="2017-08-30" version="1">MTEQTPLVTSQESQLTTKYSSTSIFPNSRGKKAFLGALGLATSLLAIQQSGIGRFGGHGGDLDCSTPPPPSESTCPDWRDQIPVSEVRILPSLIDCPGSSSQGYIEKWVKMGFFEHFRVCVENGTTCNMRDVSCPCHRNRLSRLKGDSADGSYPHLSSASSIAKVMDLHLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI11</accession>
    <name>A0A1Y1UI11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_622951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871690.1">
        <property type="nucleotide sequence ID" value="XM_022015529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI11"/>
    <dbReference type="FunCoup" id="A0A1Y1UI11">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI11"/>
    <dbReference type="GeneID" id="33557338"/>
    <dbReference type="InParanoid" id="A0A1Y1UI11"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="341" mass="38605" checksum="1A03CDA30B59D0B5" modified="2017-08-30" version="1">MLTRAGNRLVASSSRSLLVPLSRPISTIAPALERHAGTRRSLRRDDTSHRYRSRPPSRFSPGPSLDYPDYEPGEPIGGRVIPSRPVVIPPDPDGVLQDSHAARELLAHDTLVIVRQIEMLNIFVGFEQANRYAIQTTEGELVGFLVEEEQSIVSTMTRQFLRTHRPFRAIIMDRHGNPILWIRRPFQFINSRIYVRAAGEENGPLVGEAQQEWHPWRRRYNVFQTRRGGETFSQFARIDGGFWAWDFWLKNKDDQLVASINRNFRGLGRELFTDTGQYVIRFDAAGTELDMPPGAAFEVQGQKLILPSGPDGSLTMDQRAMTLATAVSIDFDYFSRHSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI30</accession>
    <name>A0A1Y1UI30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_650237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871669.1">
        <property type="nucleotide sequence ID" value="XM_022018118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI30"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI30"/>
    <dbReference type="GeneID" id="33559927"/>
    <dbReference type="InParanoid" id="A0A1Y1UI30"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="258" mass="28110" checksum="F614A80A4A70F605" modified="2017-08-30" version="1">MPPQELVVVPKTIHNVLNQMRSKIFMTAYNPTGARQGTKYLRKKPMGQKFLEYYPDTIIRPSQANSSKSHAMYPGWTGLIPGIPYGKMQKATFKEKPDTVPGPSKASIATSSPASPDASVSAPSSLEGAADLSTVAETSSSSSSSSLSTTTVSSETNSSAATTPQTQETQIQNENATATRQEMLAALKAAGIRPDSMYFGADNFFGAAPPEEYWPTAWQADWKERYRIKKLTRRRRIGKITPKKGEGKRSQLGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIF1</accession>
    <name>A0A1Y1UIF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Las1-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871365.1">
        <property type="nucleotide sequence ID" value="XM_022015827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIF1"/>
    <dbReference type="FunCoup" id="A0A1Y1UIF1">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIF1"/>
    <dbReference type="GeneID" id="33557636"/>
    <dbReference type="InParanoid" id="A0A1Y1UIF1"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="467" mass="52260" checksum="7DF5E7F6891CFBB8" modified="2017-08-30" version="1">MARPRRVPWASKSDLVDMYELLFSPESDAPTRARGMARMSIYISSPSCPAFLPLLHSLISAAETPEPRTAEERHRMRLVCAMAIVRFVNGLVDPLQTGPYARPIAHLAISLRLPPSLISLRHRATHEDLPPLDTLLGAVKQAIQYLHDSSFVPLISQDPSSTTAQMARGGGGDRPADKLIKRWKRVNKSRLREKEVGSENASGREIQSIKRDLERIDKAELVEALVSQGGLVPLAESKRPSQDGMAPSDASLQIWSPLLSSLVELHPDFIDTLSHRILDGVSPISEPLEPKTTETRDRDGSYRWGLATWLLHLWTKDDEAALSLEAKRDLWKTLLGCLVTNDPHLRRLYSQLLVLDSTLKPIALGELLRFTGAGDDMQLDGEENLKGLEEVDQPRPRVLENGNLEAKLAEMDDRLRRVKSLREQVDDRRIRSVVDDDSVASSSDPPGWRRLSRLEWSSRPIGQRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIP4</accession>
    <name>A0A1Y1UIP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871905.1">
        <property type="nucleotide sequence ID" value="XM_022015628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIP4"/>
    <dbReference type="GeneID" id="33557437"/>
    <dbReference type="InParanoid" id="A0A1Y1UIP4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="21881" checksum="E87CF122F508FD86" modified="2017-08-30" version="1">MICGYTVDLDRAATFTETFLAESFRPVISEINQRLSEDRSWAWVLSKYNAKSARRRARPVHRDRRGGYALMTQSVPGDNPKTKNDRSKYSKGREANSKGMQAPKGKRSGSDILKARCYNTSLNDIEDAWAMITIAEDPALHWADLSNDEPMDWPDEVIPWTGDDDLEHNPILHHTEPFLRMSGSWQLRSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU3</accession>
    <name>A0A1Y1UIU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_650511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871957.1">
        <property type="nucleotide sequence ID" value="XM_022018158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU3"/>
    <dbReference type="FunCoup" id="A0A1Y1UIU3">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIU3"/>
    <dbReference type="GeneID" id="33559967"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU3"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="2">
        <location>
            <begin position="324"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="574"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112181" checksum="5DF87BFB0CBAE3F3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ17</accession>
    <name>A0A1Y1UJ17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallo-dependent hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872028.1">
        <property type="nucleotide sequence ID" value="XM_022015680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ17"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ17">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="GeneID" id="33557489"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ17"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49485" checksum="FFC888FF3BB2F638" modified="2017-08-30" version="1">MRFWYLTKATRLSTHKAIRSLRMSSSSQNQPSRQTPTPTPTQTPDHDPPNWMTLKLPPAHILSHLTDAHCHPTDLDQPASAYDATSLGAVAAMATEPENQPKVRSVALARPWKKGDTKPSSSGSRIIACFGYHPWFSHRYTLQSPPPSKEEHYTSLFFPQHDSSTPPPTKKGQLLGLLLPFLPDPIEFGPLISQLSSDIRDSVSAGNLTMLGEVGLDGGARLRWPTSARHLHPDAETDDREGDNWNVLTPFKTSMAHQIAILERQFEVAIQHGVNVSLHSVAAAGPTFDTLVKMRDRHRNRFTNRINVDIHSGGGFSPDHWKQTERNLLNVYASPSIFVTSRSSHAAELIRTISKDRMLVESDSHDLTLCTRAVWGATEWIARCRGWKLEDENTPAWTLDEVIAKEEQEEQEGARTEERDEVWAVRTLERNFARFMNMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ26</accession>
    <name>A0A1Y1UJ26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_622405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871544.1">
        <property type="nucleotide sequence ID" value="XM_022015470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ26"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ26"/>
    <dbReference type="GeneID" id="33557279"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ26"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="334"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="163"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="340"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="51220" checksum="F5FAD206B73FB440" modified="2017-08-30" version="1">MAPIQVKKICCIGAGYVGGPTCAVIAAKCPHIEVTIVDLNKARIDAWNSDHLPIYEPGLDEVVKGARGKNLFFSTDVDKAIAEADLIFVSVNTPTKKSGIGAGFAADLNYLQLATRRIAEVSTSSKIVVEKSTVPCRTADAMRTILEANSKEGCKFDILSNPEFLAEGTAIADLFAPDRVLIGSLQTQSGLDACQALMSVYANWVPKERILTVGLWSSELSKLAANAMLAQRISSVNALSAICEATGASIDEVAYAVGRDSRVGPKFLKASVGFGGSCFQKDILNLVYLSESLHLPEVARYWRAVVEMNEHQKDRFARKVVDTLFNTITGKKIAMLGWAFKKDTGDTRESPAISIANHFLSEKARITCYDPQVTSEQMWLDLTDYGSIPAEPIKPHFSVCQSAEEACANAEAIVICTEWDEFKELNWEKIYENCPRPAFVFDGRLMLDRKRLQKIGFTVVTIGTGDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJD8</accession>
    <name>A0A1Y1UJD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adhesin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_655995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871601.1">
        <property type="nucleotide sequence ID" value="XM_022018832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJD8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJD8"/>
    <dbReference type="GeneID" id="33560641"/>
    <dbReference type="InParanoid" id="A0A1Y1UJD8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="75283" checksum="6231AB840BF4F3A1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJG6</accession>
    <name>A0A1Y1UJG6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871631.1">
        <property type="nucleotide sequence ID" value="XM_022015506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJG6"/>
    <dbReference type="GeneID" id="33557315"/>
    <dbReference type="InParanoid" id="A0A1Y1UJG6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="97" mass="10884" checksum="BA3D853D1476F825" modified="2017-08-30" version="1">MLVPLRGALRSNVGHAVTQKSRCKTQREQLGGPSSGLADRLVIRRKVKPMTRTPSRWHLLQVKKEFQKFADRLKKTLLTLILGIGSGRPVCQSLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJQ4</accession>
    <name>A0A1Y1UJQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_672555</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871721.1">
        <property type="nucleotide sequence ID" value="XM_022018939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJQ4"/>
    <dbReference type="FunCoup" id="A0A1Y1UJQ4">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJQ4"/>
    <dbReference type="GeneID" id="33560748"/>
    <dbReference type="InParanoid" id="A0A1Y1UJQ4"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="370"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="479" mass="53838" checksum="E5ADBB22A4618A71" modified="2017-08-30" version="1">MDSYQTPLSSRYASKEMSKLFSNATRFGTWRQLWLSLAIAEKELGLAISDKAIEQMRANLELDEAQMKVAAEEEKKRRHDVMAHVHTFGTVAPEAAGIIHLGATSCYVTDNADLIFLRQGLSLLLPKLAIVISRLTTFAERYRDLPTLGFTHFQPAQLTTVGKRATLWIQELLWDLRNLERAKNDLGFRGVKGTTGTQASFLALFEGDHDKVEQLDERVTELSGFPYAYPVTGQTYSRKIDADVLGPLSSFGATVHKICTDIRLLANLKEIEEPFEKDQIGSSAMAYKRNPMRCERACSLARHLMSIYQNTVMTSSVQWLERTLDDSANRRVTIPEAFLTADILLSTLQNISEGMVVYPKVIGRRISQELPFMATENVIMAMVKAGGDRQVCHEKIRVLSHQAGAVVKEQGGENDLIERIKADSYFEPIWSQLEALLDPSTFIGRAPQQVDKFVRDWVQPALKPYAEDLKHIQSAELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJV8</accession>
    <name>A0A1Y1UJV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872260.1">
        <property type="nucleotide sequence ID" value="XM_022015288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJV8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJV8"/>
    <dbReference type="GeneID" id="33557096"/>
    <dbReference type="InParanoid" id="A0A1Y1UJV8"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29387" checksum="B35282DB9B854874" modified="2017-08-30" version="1">MRIHLSVNSHQLDPSSGAGPSSGPLAKIGGELVLIELQGELSWEGEQSGKVVGVLGLDRPDKPTLHLGEHHLLHGKITTLQKPYAVIRRQLETVPMDDEEGDRANQSDDGEAADDDHDDEDDTTPDKKLRSKHGQGNDDEEDEEDEEPLFPLSDPIRTPHHTGAPPSSSPIYPPSVARDYSSELGFSSPARWDAEDEQEDEDEEAQTTRAALEIQRLTAQKRRGKRKRGEKQVRTKHYEVVGVVWKKVVFALRPEPIVTATVLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK05</accession>
    <name>A0A1Y1UK05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_626286</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 14"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871493.1">
        <property type="nucleotide sequence ID" value="XM_022015880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK05"/>
    <dbReference type="FunCoup" id="A0A1Y1UK05">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK05"/>
    <dbReference type="GeneID" id="33557689"/>
    <dbReference type="InParanoid" id="A0A1Y1UK05"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011825321" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="322"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX37455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="502" mass="55263" checksum="5CF820C4063586BF" modified="2017-08-30" version="1">MRYSTLLSLLATFTAGALASDVIDLTGGTFKSEVNGEDLALVEFFAPWCGHCKNLAPHYEEAATELKSKLGVKLAKVDCTEEAELCKEFGVNGYPTLKVFRNGVPTDYAGPRKADGIISYMVKQSLPAVSEVTPSSHDEFIKQDKVVLVAYGDESHPVPAAFAEYANSARDTYLFGQYLDSSLPSIPESPSLPAIVLYKQFDEGHNVLSTSEVSSLTADSLAEFIKSNSMPLVDEISPENFGDYAERGLPIAYVFAEPDDTATREQFIEEIKPIVKEFKDKVSFVTIDAVRFVDHGKGLALPGEDWPAFVIQELAEQSKYPLDTKFSAKNVEAHLRAYVDGKLSPKIKSEPIPKTQDQPVYHLTADGWDALFGDDSKDVFAEFFAPWCGHCKKLAPVWEELGEKYQNSKNVVIAQMDATLNDIPPTAPFKVAGFPTLKFRPAGSSDFEDYMGGRTLEDLIEFVEANKKSEGPLSTEEAVEERSDEDSAVAGEEEEVVEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKD7</accession>
    <name>A0A1Y1UKD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_413359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871984.1">
        <property type="nucleotide sequence ID" value="XM_022012717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKD7"/>
    <dbReference type="GeneID" id="33554525"/>
    <dbReference type="InParanoid" id="A0A1Y1UKD7"/>
    <dbReference type="OrthoDB" id="2575102at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52062" checksum="95DC388B328B5EA3" modified="2017-08-30" version="1">MVRLAGLGLDPTGIVFHDSSRVIKQASFYRNSAVETNLISFYLGTVPTHTDIFDREKARNLFPRFATLPESLMDDETAYVFACLCKAADMRVQERWSGTDIPESDRKQFQDLAIGYYHLACEAVGQASIPSILTLSALQYLTTFAAARGSRTQTMNLLQKMGWQVHQLGLCKKATANLYDLSDGAGQLLASVLYMDSQCGILLDLSSQILTSELDWDPSIDTPPPISATSLKVMRLEADFLDLSTKIDFQNDVHLVLRTESNWSSFLKSVHIQHTTEKEGMRHSFLGWALIRVSMLSIMLRSPLLYHETLGSSSLSIVARSASTVLRVYWDLTLIGKLEPCWPQLRRITTCIQLVILTCAEGHLHPTEARDLLSIGIDLVRKHEPVSDTAVQMAASFQNAKNKLLHGLSVSQLSPSDPLGDLSSVGTGHEAGSGNPNAEMDWPSFFAGLTDMDTNPFTEESPFDLLDKGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKE4</accession>
    <name>A0A1Y1UKE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872445.1">
        <property type="nucleotide sequence ID" value="XM_022018058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKE4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKE4"/>
    <dbReference type="GeneID" id="33559867"/>
    <dbReference type="InParanoid" id="A0A1Y1UKE4"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="348" mass="36042" checksum="FB9C86A7E0D5E400" modified="2017-08-30" version="1">MSFAPPAGPPPPPRHPIGSSTNRQAARQDSVDQAVLDEEPPPAYHSVVSGGASDAVLDAGPSRMDFSGPPPLPERLQAVGTGSGIAHHVTGVGEGYGRRPPHATGFESPFADQFQSSQGTSSYPVSERFEAPAGPPPGKSSGGYAGPSTHSSRPPSPPSHPSSSGGAGSSSRPGSDLTPTDVPTPGRPLLHNGMMLVYPKGHFCTKCYNTGYKANDPRNPHEADWRKYGKHYTSALAHSYSVSSGPGASSAADNFQRPLPNHQPAGPGSMYGGAAPPPSPNKWNTYPGHSVPTHQHAPPPGSWQGHPGPGQGNLMMHPPQPHLYPSHTMTPPPGAIVLQAGDPRIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKF0</accession>
    <name>A0A1Y1UKF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rad9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_600435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871971.1">
        <property type="nucleotide sequence ID" value="XM_022013918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKF0"/>
    <dbReference type="FunCoup" id="A0A1Y1UKF0">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKF0"/>
    <dbReference type="GeneID" id="33555726"/>
    <dbReference type="InParanoid" id="A0A1Y1UKF0"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="575" mass="63493" checksum="4088CCC5157047EF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKI6</accession>
    <name>A0A1Y1UKI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_649925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872485.1">
        <property type="nucleotide sequence ID" value="XM_022018063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKI6"/>
    <dbReference type="GeneID" id="33559872"/>
    <dbReference type="InParanoid" id="A0A1Y1UKI6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="278" mass="30916" checksum="986405202AC826D6" modified="2017-08-30" version="1">MKGLGYPSPPVRLYTYPESGEENGLPDQIELTRHTKQVPEGFESDWDRALTLLDSFGSERGWDSRNESHQEALLKAIAAEMVGSKPTELLFNQRDGTITTRSVSDRSEALYEWPKHRPGTPGLVSVRLSTVGRLTFAQVFDSYLKGKKLRIDDLSVQDSQDSLRRTVSIKIKPMQTQGEGEATMTAGHAEDLNAFAGLLSYAPDDSRVHSGLRLATETASIDVAACLRFKRDRVLHTENDELIPTTLERVVPFLQLVLTTDPNEEVMEILNQSGGSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKV9</accession>
    <name>A0A1Y1UKV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872099.1">
        <property type="nucleotide sequence ID" value="XM_022015218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKV9"/>
    <dbReference type="GeneID" id="33557026"/>
    <dbReference type="InParanoid" id="A0A1Y1UKV9"/>
    <dbReference type="OrthoDB" id="3366352at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="78968" checksum="3FD53BC873A08A40" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKY4</accession>
    <name>A0A1Y1UKY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_599677</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872640.1">
        <property type="nucleotide sequence ID" value="XM_022013908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKY4"/>
    <dbReference type="FunCoup" id="A0A1Y1UKY4">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKY4"/>
    <dbReference type="GeneID" id="33555716"/>
    <dbReference type="InParanoid" id="A0A1Y1UKY4"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="11">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="562" mass="61936" checksum="B2D7BEC8EE5CA060" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULC6</accession>
    <name>A0A1Y1ULC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-3 sterol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_641213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872704.1">
        <property type="nucleotide sequence ID" value="XM_022017407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULC6"/>
    <dbReference type="FunCoup" id="A0A1Y1ULC6">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULC6"/>
    <dbReference type="GeneID" id="33559216"/>
    <dbReference type="InParanoid" id="A0A1Y1ULC6"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="300"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="48156" checksum="C655B32226C388BB" modified="2017-08-30" version="1">MPGEESYLIIGGCGFLGRWIVDQLVERGETKVAVFDIVQRHFDNNITFFTGDLSNAADVENAIVKSGATSIIHTASPHYTAPADILERVNVTGTSNVVDMCLKHNVRKLVYTSSGAVYLDGIHQLISADERLDYAEKPLDVYNTTKIEAEKIVLNANDRSGEGLLTCCIRPCGIFGPGDQNNIKQWHRVVLNGQTKWQIGDNMNINDFTFVGNVARAHILASDRLAESYPCDRFRDPLPSIDLSVGERRVPTSEARPLGPNTSPSEKDLEVAKRFASKEYDPNDLRPVLRNRMDHFSEQSNLEDESASVPVAGQAYFVTNGEPVYFWDFARTVWKHFGPLPTSYWVLPVALGYIVGLLSETFAKISGRQPGMTRYNISQVVQNRYFSIEKSRRLLGYEPTVGIQEGIQLMADWYKEELAKKGEPESKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULH8</accession>
    <name>A0A1Y1ULH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_576560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872764.1">
        <property type="nucleotide sequence ID" value="XM_022013196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULH8"/>
    <dbReference type="FunCoup" id="A0A1Y1ULH8">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULH8"/>
    <dbReference type="GeneID" id="33555004"/>
    <dbReference type="InParanoid" id="A0A1Y1ULH8"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="92"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="568" mass="60380" checksum="06BF5672658774E2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULM7</accession>
    <name>A0A1Y1ULM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_620897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872369.1">
        <property type="nucleotide sequence ID" value="XM_022015335.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1ULM7"/>
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    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="407" mass="45826" checksum="287C0644B54E3231" modified="2017-08-30" version="1">MTMMDVQSLVNALRRRYAAPRVDPEWVRQCAQALIEDGQQATLEAVHDQFLWSNLAHSTLPSNATPADPSSSQSALLFVEPTLLQIESITEIGSSAFQLQNTVNMRRVVIEGRTRIRRIDDPADGEEVDDANMPVYPRGMLRFELSDGRSKVRAIEYKRLNGLKLGETPLGCKLLVHRVRSVRGILLLQPENTDIIGGMIEDLEAKQAECFISSLKARMDAAARREAQPTVPVRRTRAAPRATTRPPPPRPARQETATQRMVPGPSTPNTSSRPQRAAGQFASARIGRMYDQIAHPDRDAVIGAAEGSDDEFESFHVDESFFRRVDQAERQAERQASRGRNDIHQVESDEFDDIDVDDSFIRQIDEVEMRSWNRRQVQKRGRGDLDTEDLEDFDSGKENKPIVIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMA1</accession>
    <name>A0A1Y1UMA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872528.1">
        <property type="nucleotide sequence ID" value="XM_022018068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMA1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMA1"/>
    <dbReference type="GeneID" id="33559877"/>
    <dbReference type="InParanoid" id="A0A1Y1UMA1"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="155" mass="17531" checksum="1121D7D3F26C5335" modified="2017-08-30" version="1">MVLSISSRRLMKELKEIETKGTPPGIQLLKADDMETWIFLISVLGDETVYKGETFALKLKFEPGYPIDYPQVTFLSDDQYQPPLHPHVYSNGHICASILGSEWSPVLTALSICITIQSMLASCKKKERPPGNDRYVRSAPLNPKLTRWAYEDDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMR4</accession>
    <name>A0A1Y1UMR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_588785</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872347.1">
        <property type="nucleotide sequence ID" value="XM_022013769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMR4"/>
    <dbReference type="FunCoup" id="A0A1Y1UMR4">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMR4"/>
    <dbReference type="GeneID" id="33555577"/>
    <dbReference type="InParanoid" id="A0A1Y1UMR4"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="17">
        <location>
            <begin position="86"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX38425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="405" mass="46268" checksum="4473B296B47B0D83" modified="2017-08-30" version="1">MASQKDENIQVVGHERFGFDSRAETKTLRSLYLSPSANKDLDANSQNQEYGSQSTYDKASNTVKYTTLANFPPVRLLPNSERKRILVTGGAGFVGSHLVDRLMLLGHEVTVLDNFFTGSRTTVSHWVGHPNFELVRHDVVEPFLIEVDQIYHLACPASPPHYQYNAVKTLKTSFQGTLNMLGLAKRTKARFLISSTSEVYGDPEEHPQREDYWGHVNCIGPRACYDEGKRVAESLTYGYSRQDGVEVRVARIFNTFGPRMNPYDGRVVSNFIIQALKGEDMTVYGDGSQTRSFQYVHDLVDGLILLMNSDEERPVNLGNQDEFTILEFAEAVRDIVEKVQKEKGNPLAKRVNIIHKEIPQDDPQRRRPDTTRAKETLQWQPQWSVRQGVEEMVRYYYTQIEEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN55</accession>
    <name>A0A1Y1UN55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_577371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872749.1">
        <property type="nucleotide sequence ID" value="XM_022013253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN55"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN55"/>
    <dbReference type="GeneID" id="33555061"/>
    <dbReference type="InParanoid" id="A0A1Y1UN55"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="529" mass="57459" checksum="84CBECE922FA3D03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNT8</accession>
    <name>A0A1Y1UNT8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase I associated factor, A49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_576075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873486.1">
        <property type="nucleotide sequence ID" value="XM_022013171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNT8"/>
    <dbReference type="FunCoup" id="A0A1Y1UNT8">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNT8"/>
    <dbReference type="GeneID" id="33554979"/>
    <dbReference type="InParanoid" id="A0A1Y1UNT8"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="434" mass="47903" checksum="CDF9FF4C6F6DCC6C" modified="2017-08-30" version="1">MSSAERSKKSHKRKSVAVEDGMEAGPSTLNVTVTEPSSSLGPVFVNFPSIRPSKDTPFRLYSRDADSGEELALQATLLAGDTEDVDFVSSNRNHGGSNESSDCQYLPAVYDPDAGTLQIHASSPLYLMVHRSKRMTNVALQMEKADDYRTKRNNLGEVFGTRKAKSQIRAEERNKLNADAMQDVRGHLMETIGAKEAEAEALPSELIPTPNTSTDDPAQVYPRESMISDGEWSCIDASTLLKQKDDRSRALLLPYRRSRFIETKMREVSGSAISSSLKKSSMRMCFFLSSLMALNDRSGDIARSTTAELGSKFSAIPAPLLNGLLERFTESLGNKRKITDKLQTKLLAWICVAYLHLSDFKADVTSIAKDLSFQPAKLINIFKSLGCRIDIPSPEEREQLGVTLDGAKALRKAVLRAPVQFPKPKTRAPARGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNU2</accession>
    <name>A0A1Y1UNU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_317908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873070.1">
        <property type="nucleotide sequence ID" value="XM_022012469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNU2"/>
    <dbReference type="GeneID" id="33554277"/>
    <dbReference type="InParanoid" id="A0A1Y1UNU2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="166" mass="18166" checksum="973976BB82F5A7A5" modified="2017-08-30" version="1">MDSQQVDSSDATKNSCKSGLDARAVWLCMRFPSFEKVLFSDQKDSKAFPTATAANSEQQVLSLIARLGYLTGRSLQARTPSELEAYISLVSTDIDALVDRFSRMSQAYPLPEEPWLASAEVSVGPGGIDAIWVLSRPRGEYDIKQKLRTISADTLAAAVRYQTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP57</accession>
    <name>A0A1Y1UP57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_325540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873190.1">
        <property type="nucleotide sequence ID" value="XM_022012487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP57"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP57"/>
    <dbReference type="GeneID" id="33554295"/>
    <dbReference type="InParanoid" id="A0A1Y1UP57"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29903" checksum="30F47E45CDA874D1" modified="2017-08-30" version="1">MVPAIDRTEQGAETVTEVVRNEQRPIRVLVTGFGPWASNTVNPSNSVASKLPSHLPGTSGRPPIEVIVKSPIPVSYHKIHESIPKLLEDVQADYVLHMGLHGGRPTFDLELSAPRTGFVHPDVDTKCWTLEEGDKVVPGQSVLPYQLDKNAKDDDGSNVGAEPSEDGEQSWPDRLETQLKRDKVVEIWQERCKEVPNSQVTGNDGVGTFCCGFIYYTSLAWYKKQNVKGEGQKTGPVLFLHMPNLQEEHEVEMGKQVVIRLIEAIVEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPI7</accession>
    <name>A0A1Y1UPI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_327969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873239.1">
        <property type="nucleotide sequence ID" value="XM_022012502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPI7"/>
    <dbReference type="GeneID" id="33554310"/>
    <dbReference type="InParanoid" id="A0A1Y1UPI7"/>
    <dbReference type="OrthoDB" id="2587036at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="145" mass="16048" checksum="F89171780D809EFC" modified="2017-08-30" version="1">MLLSPLLCHESLSQLVESGPHTALLASPHGSVVASARRPEGERDETNDDDDEEEEEEEEDEGPWLDEPERMRLLLGLASQWTTDESPRIECELGRLYIRSIPLAPEETLPANSGVPSIRSPYIGNFLLVLNGSSETPWTVLADKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPP7</accession>
    <name>A0A1Y1UPP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873332.1">
        <property type="nucleotide sequence ID" value="XM_022017374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPP7"/>
    <dbReference type="FunCoup" id="A0A1Y1UPP7">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPP7"/>
    <dbReference type="GeneID" id="33559183"/>
    <dbReference type="InParanoid" id="A0A1Y1UPP7"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="543" mass="57541" checksum="2AD93170BB1522F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPT5</accession>
    <name>A0A1Y1UPT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_648679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873853.1">
        <property type="nucleotide sequence ID" value="XM_022017873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPT5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPT5"/>
    <dbReference type="GeneID" id="33559682"/>
    <dbReference type="InParanoid" id="A0A1Y1UPT5"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF144">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="162"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="521"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="896"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="105955" checksum="82A3299D8EEB51DB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPW0</accession>
    <name>A0A1Y1UPW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_606883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873329.1">
        <property type="nucleotide sequence ID" value="XM_022014035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPW0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPW0"/>
    <dbReference type="GeneID" id="33555843"/>
    <dbReference type="InParanoid" id="A0A1Y1UPW0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="553" mass="61147" checksum="6B294C306EE06D3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPW2</accession>
    <name>A0A1Y1UPW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal S13/S15 N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_616255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873885.1">
        <property type="nucleotide sequence ID" value="XM_022014815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPW2"/>
    <dbReference type="FunCoup" id="A0A1Y1UPW2">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPW2"/>
    <dbReference type="GeneID" id="33556623"/>
    <dbReference type="InParanoid" id="A0A1Y1UPW2"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="151" mass="17005" checksum="2C0E278F648A6AE9" modified="2017-08-30" version="1">MGRMHSKGKGISASALPYRRSQPSWSKATPEEVCDQIFKFARRGLTPSQIGVILRDSHGIPQVKFVTGNKILRILKTNGLAPSLPEDLYCLIKKAVSVRKHLERNRADKAAKFQMILIESRIHRLARYYIKTQQVPPTFKYEAATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPY4</accession>
    <name>A0A1Y1UPY4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_679149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873876.1">
        <property type="nucleotide sequence ID" value="XM_022019029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPY4"/>
    <dbReference type="GeneID" id="33560838"/>
    <dbReference type="InParanoid" id="A0A1Y1UPY4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="24106" checksum="72AE173954A354CF" modified="2017-08-30" version="1">MIQYMSHDPKDPSETPKPKSQGLLARLKVKLMPKKKKKNRASGGVESTDAGMPPLADAPDSTGIHEAADMPDASLPLDSSHKEPNRNVQTGQPDLGQHTNSRDHSTQGGQTVQTAQVSHTTQTTAPAPAQAQGPPTHVPTLHLPPAAVAPPTPHQTSQSAPGGTGHLGHHGGHSHHSLGDAGVGAAVAPAHGGHSDSNTCSYSHTHSHSHDAGTSSYNSSYGGAGGGSGGYSGMSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR60</accession>
    <name>A0A1Y1UR60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_678740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873410.1">
        <property type="nucleotide sequence ID" value="XM_022019011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR60"/>
    <dbReference type="GeneID" id="33560820"/>
    <dbReference type="InParanoid" id="A0A1Y1UR60"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="60493" checksum="7659008C57EDFC77" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR71</accession>
    <name>A0A1Y1UR71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_9230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874257.1">
        <property type="nucleotide sequence ID" value="XM_022019278.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UR71">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR71"/>
    <dbReference type="GeneID" id="33561087"/>
    <dbReference type="InParanoid" id="A0A1Y1UR71"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="183"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="285"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="379"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="535"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="624"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="707"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="782"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="861"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="935"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="1240"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1310" mass="138370" checksum="4C743C390DF2F65D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URE5</accession>
    <name>A0A1Y1URE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_574695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874208.1">
        <property type="nucleotide sequence ID" value="XM_022013080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URE5"/>
    <dbReference type="FunCoup" id="A0A1Y1URE5">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URE5"/>
    <dbReference type="GeneID" id="33554888"/>
    <dbReference type="InParanoid" id="A0A1Y1URE5"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="130"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="302" mass="33177" checksum="34D67F504F51C4E2" modified="2017-08-30" version="1">MRIGSASTTALVRRIPHLSSRQAPLQPPCNRAFAYRRCLADSTSKPQRACPSCQAHLPVTTTPCSECQKLLPFPSGLSHHSILGERAPFPLPATPFSAVSADLSCVSLSLSSLGLSEPILADSSSSITFDIPAELSTIPSHGYVLDVREARNKMLHRQRELHPDKFASEGEVIVQLARDLSGRVNEAYSVLADPLKRADYILSVHSSATEESDSLDDPMLLAEIMEAREDLENAETKDEVDRLGEENQERIESTIAQITEAFSQQPPDIVGAKGLAVQLRYWRGLEDAIRDWEPGKSQVMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URN9</accession>
    <name>A0A1Y1URN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S11-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_678053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874281.1">
        <property type="nucleotide sequence ID" value="XM_022018970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URN9"/>
    <dbReference type="FunCoup" id="A0A1Y1URN9">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URN9"/>
    <dbReference type="GeneID" id="33560779"/>
    <dbReference type="InParanoid" id="A0A1Y1URN9"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34658" checksum="12509622AA6CD811" modified="2017-08-30" version="1">MALRTALSGSIRPVYRITPFASEHLIASTSRAGFHSSTSKREDSKPPSSSSSSQGPQAAPRAQRAPVQTTTVLQDAPPPPPPPPAVARFPFGETPAPRTKPKPSASFTLHPDQPSQVYPKQRRDGSAFEPEPTASRSSSKSTSSPSNPLPNLFGEKKAPRIPMASAMKEIKGGSMLSDNPRYAPITNLPDDESLTHTLYINSTRNNIQLSLQDALGKLGPTISGGTGRTFKGQGRSSVEAAHQATVKMMDRVLEYSRKLPDARIRLRLTFRGMQGSGRETVFNAITGPTGDDFRPFIGRVEDRTPLRWGGRRPRKARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URP1</accession>
    <name>A0A1Y1URP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_617144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874062.1">
        <property type="nucleotide sequence ID" value="XM_022014889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URP1"/>
    <dbReference type="GeneID" id="33556697"/>
    <dbReference type="InParanoid" id="A0A1Y1URP1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="81" mass="8932" checksum="80A257E3B3E834EF" modified="2017-08-30" version="1">MSNTSEAPLYKSTVFSTTSGQWLDTEQGQTLYAKYYDGSVDTNGPIAYVSSSQQFKHSTAPTRTRTNSSGSIIITERVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US24</accession>
    <name>A0A1Y1US24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_612037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874441.1">
        <property type="nucleotide sequence ID" value="XM_022014336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US24"/>
    <dbReference type="FunCoup" id="A0A1Y1US24">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US24"/>
    <dbReference type="GeneID" id="33556144"/>
    <dbReference type="InParanoid" id="A0A1Y1US24"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="253"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="406"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="563"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="733"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="940"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1244" mass="137572" checksum="690CBFBAA628CCD0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTT4</accession>
    <name>A0A1Y1UTT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_606724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874706.1">
        <property type="nucleotide sequence ID" value="XM_022014025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTT4"/>
    <dbReference type="GeneID" id="33555833"/>
    <dbReference type="InParanoid" id="A0A1Y1UTT4"/>
    <dbReference type="OrthoDB" id="3224257at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="628" mass="67872" checksum="D0F8A9BCD9FE8FBD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTZ5</accession>
    <name>A0A1Y1UTZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide exchange factor in Golgi transport N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_613164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874776.1">
        <property type="nucleotide sequence ID" value="XM_022014474.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UTZ5">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTZ5"/>
    <dbReference type="GeneID" id="33556282"/>
    <dbReference type="InParanoid" id="A0A1Y1UTZ5"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="195"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1264"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1589"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1655" mass="178403" checksum="60C24D7C24CE1F36" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5N1</accession>
    <name>A0A1Y1U5N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_654235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000025">
        <property type="protein sequence ID" value="ORX33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867688.1">
        <property type="nucleotide sequence ID" value="XM_022018771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5N1"/>
    <dbReference type="GeneID" id="33560580"/>
    <dbReference type="InParanoid" id="A0A1Y1U5N1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="294" mass="33451" checksum="76F5D98FC4FD0900" modified="2017-08-30" version="1">MGTEDEIPHPWSPLESRALQWIVTCTDHPIAHERPSLPSHGKPTPESTLFPQLVQVEAIAPSTLFDSSPPVRQNLGMDWNDLRAEEDPQLCQLVLVPHATHPWILSPSSYPPDLQAYYTMNPRSNTATIERILSRVLKENGRLHVQLTRLPAHRNILIPSTIPTPERPSYWAIRVSCLISQQTQDTIWNSVHDALDSGCKVSVKGNRRTDAQFQPFHAGVLFRSSQLNQPWVTNDLLQKRGPASAQQVRRQKMLHVLRSVDKLANGPVQRVLNHIDRLTWRRHHAISTQFRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5T7</accession>
    <name>A0A1Y1U5T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal L28e protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_639930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867724.1">
        <property type="nucleotide sequence ID" value="XM_022017297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5T7"/>
    <dbReference type="FunCoup" id="A0A1Y1U5T7">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5T7"/>
    <dbReference type="GeneID" id="33559106"/>
    <dbReference type="InParanoid" id="A0A1Y1U5T7"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="165" mass="17958" checksum="1A06A4E93AB67F61" modified="2017-08-30" version="1">MSADLHWLLLRKWNSFQHPGVKGGPTLSKEHGNLRNIHSHKYSGLSNHNSVSIFADKNGAITFTKLKKDVAPNKVRDARSSSTLRRTTGSRRANKIAAVETAGKGYRADLRQAAVARISALSRANARTAAPRKEFPAKTRGKKSVSGGSKAQSGKKEDDDVIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5W5</accession>
    <name>A0A1Y1U5W5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_610656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867718.1">
        <property type="nucleotide sequence ID" value="XM_022014207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5W5"/>
    <dbReference type="GeneID" id="33556015"/>
    <dbReference type="InParanoid" id="A0A1Y1U5W5"/>
    <dbReference type="OrthoDB" id="3359404at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="209" mass="23107" checksum="9646927919C6CB10" modified="2017-08-30" version="1">MASLRTSLNTVRNLLTPRHLSLQATNNQLSTTPGPNSMLRRSLHQSRTSKLASPTSSTSTSSSRLSSTPHVSNGPRPTGSTASSSSTSSTGGSSSGKKPPSRHLIWYREIVPAMLPIIFLSSTIFLSLTLVRTHLSHRKSLEESTAKIQELELQLAKLRREQRIAREREKRERERILPLLVGRVLKKVGVVGHEEEMEVGAEEDERLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6D6</accession>
    <name>A0A1Y1U6D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_639307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867881.1">
        <property type="nucleotide sequence ID" value="XM_022017217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6D6"/>
    <dbReference type="GeneID" id="33559026"/>
    <dbReference type="InParanoid" id="A0A1Y1U6D6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="58488" checksum="FABBEAC46BFEB5DF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Y9</accession>
    <name>A0A1Y1U6Y9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_654265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000028">
        <property type="protein sequence ID" value="ORX33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867641.1">
        <property type="nucleotide sequence ID" value="XM_022018780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Y9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6Y9"/>
    <dbReference type="GeneID" id="33560589"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Y9"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="6"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="590" mass="65364" checksum="1089EB321A86557F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U790</accession>
    <name>A0A1Y1U790_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_684309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000023">
        <property type="protein sequence ID" value="ORX33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867706.1">
        <property type="nucleotide sequence ID" value="XM_022019212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U790"/>
    <dbReference type="GeneID" id="33561021"/>
    <dbReference type="InParanoid" id="A0A1Y1U790"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="232" mass="26096" checksum="3684D5172D2BA0C9" modified="2017-08-30" version="1" fragment="single">MSQTKRQANPPKTSVQRVERPLLLLRLKGCGCEQCQHLETFQERLTSRDKSFDVVRNPVSHPDVDGRELWPQVRNLTGNDSRIILLTWGYSGTGKSTLIRSLLSYAKDESSAPVHIVEILGSKIYDLVKAMRLRGSQRWKPSQVTEKKKEQCVVENDSFAETVPPGRITEDFMKQIEGVREVASTMNNQASSRSCLLIFIGSNIVLGDLPGTERSEEVTDLKDPRSGRVLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7C2</accession>
    <name>A0A1Y1U7C2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_637717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868211.1">
        <property type="nucleotide sequence ID" value="XM_022017036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7C2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7C2"/>
    <dbReference type="GeneID" id="33558845"/>
    <dbReference type="InParanoid" id="A0A1Y1U7C2"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="30373" checksum="5C6944584C81DF6B" modified="2017-08-30" version="1">MIRTIYISRHGARQDWINPDDSISVTGMYHDPSLSEYGLSQVEELGDFLSHPVDDLPVPDMIFSSGFYRCLQTARPLAAKLGKPVHVELGVGEWFSKASEGSGLHSRPHAVETLSKHFAPTMLEPRYKSTVYPSRRGEDVEELRQRIKLFLGAFIKRIESEYPDVQTISIIAHAATVIVMGQVLLDDETKNIKAGTASTSCYTRDNADGPWAQRLNGETSYLSGGEVRNWSFDEVKYRDGKVIEDRGDGKPFTEVDELPVGLGKDFERYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7I6</accession>
    <name>A0A1Y1U7I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_684210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867831.1">
        <property type="nucleotide sequence ID" value="XM_022019210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7I6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7I6"/>
    <dbReference type="GeneID" id="33561019"/>
    <dbReference type="InParanoid" id="A0A1Y1U7I6"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="39510" checksum="93AFAAB4561B0955" modified="2017-08-30" version="1">MSDIGAQSDAAKRAAARKAKILARGNAGLQKLAQTARGEEADKLYGEDSRPTSPSSESTSASSPTSGANVKSAPKASSWASTGSGARAGAGAGAGAGGFGGMSEEQQRMQQDLAAMFGGFPGMGGPGGPGGGAGAGGEGMPDMSRLLAQMMGGMSGPPGQGQNLLGDLDDPAGLGTGGPFGGAGAGAGGAGGMPPMPPGMAEMFSGLNGGGAGGGFPGMPGMPGLGGGGGGGGSISKSQRYFPLIHAGLMLLLGLFTVIWWEPSLRGARLAGKIDPWWARRWAGLAGRAGVVDGLREGLLGGVEVLPLFWAFTTVQLILHTTRIMILKSPPPPHSLISTFLPLMPPAISRPLITGSRYVSLLSQLYKDGALLIFIIGMTTVLGQWRSTGVAPSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7J5</accession>
    <name>A0A1Y1U7J5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_585049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867823.1">
        <property type="nucleotide sequence ID" value="XM_022013719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7J5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7J5"/>
    <dbReference type="GeneID" id="33555527"/>
    <dbReference type="InParanoid" id="A0A1Y1U7J5"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="309" mass="33451" checksum="1A3DF8A32758A9D4" modified="2017-08-30" version="1">MVYQPASWDGRETSLLTQYLAYIPSADFDTLDAYMKNRNSALFNQDGIPGQLAAQINTAYPLAATVDGPGGSKDSTSSDGGDNGKTRKIIIGVCVGIGGMLWIGLVFWIYKRVKRSNETSVHRRLSEHMSMFGDFRRSEYAGRRVSRAPSLSPSEIDGRPSSFYASPLENDRSMRQVQGDPFADGMATGVSGYSAYTGATGTTGGGDTPTNYGPSVFGNSWFAQPGGRKDMPHPPVPGMTGGGRRSPPTMRQSQNPFEDIVTRSFLTTSGSMEGINRRAPGVSKGMISQPILQQHSLEWDEQEHRGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7P2</accession>
    <name>A0A1Y1U7P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_194161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868338.1">
        <property type="nucleotide sequence ID" value="XM_022012144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7P2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7P2"/>
    <dbReference type="GeneID" id="33553952"/>
    <dbReference type="InParanoid" id="A0A1Y1U7P2"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="555" mass="62258" checksum="91DC64CA10F41BA6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Q9</accession>
    <name>A0A1Y1U7Q9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_638178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868336.1">
        <property type="nucleotide sequence ID" value="XM_022017088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Q9"/>
    <dbReference type="GeneID" id="33558897"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Q9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="176" mass="19625" checksum="020DCD2683450C64" modified="2017-08-30" version="1">MHHIEKDKRPVCTGVPRRPVPSLHLRSLLGQSVPVLPGVDSTIRRRMLRSGRSVKCTREMRCQGCGGLESTLSFVETFNVLKSGLDEPCRSEQDGSTEEDTDDVHCHFGSHRCKVEAHYADTDTRERKEGMEDDSSGGESCGLVDIVGSLHPELVILQLLIRIGPAWIHLLHSLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8D1</accession>
    <name>A0A1Y1U8D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000023">
        <property type="protein sequence ID" value="ORX33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867714.1">
        <property type="nucleotide sequence ID" value="XM_022018768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8D1"/>
    <dbReference type="GeneID" id="33560577"/>
    <dbReference type="InParanoid" id="A0A1Y1U8D1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="277" mass="31434" checksum="03A5E64BE9153365" modified="2017-08-30" version="1">MSSPYRARKLRPLTGDRERKGNQVSDFKTDVILSENKLRRCLPIERSFTSYSLPQNQQHALRLIRMGHGMPRLVLPITLCCPTVLPDNARLYPFLLRSLPVLKLDSQVKTLHRWALGAKQNGANSIRRIMNWRLDMSGDDMNELMNDLGSKAVCPAFIWQPRIQCCACSSSGMACLIGSTGPPIGLEQGAVSITCLGCIAQNTPCRFHLSFDRGDHEETWPDIDIYARPMVDSTHPIRLEETIWWDKDGTCIRIPHSFPAGWAQQQWLRLNDIEEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8L4</accession>
    <name>A0A1Y1U8L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_583273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868643.1">
        <property type="nucleotide sequence ID" value="XM_022013611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8L4"/>
    <dbReference type="FunCoup" id="A0A1Y1U8L4">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="33555419"/>
    <dbReference type="InParanoid" id="A0A1Y1U8L4"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44459" checksum="313994CD50572B9C" modified="2017-08-30" version="1">MLPLPGSSKRRARPSYPYPPQSPSTTSLINLLRTRTRLTNLAVFILCLTLIISLLFNVSGYLAGSERRMRSSSMGYGYGYDGVEDAKTHVPASIEATIDRDPKLGLLDHLILVPGHALWIGHDAVSVEDDEDWILEPIQKGGSVKTYIQHVREGVKQLKEDEKALLVFSGGATRPPPSPLLTESQTYLSLAQTLSLIPSTPFPPHSTASNHDPLPLNARTTTEEYALDSYENLLFALARFKEFTGRWPVKITVVGYGMKRRRFEQLHRAAIRFPLEHFDYVGIDDEGDTTEHYAGELQYGFGPFVHNPSGCHPPLSTKRLLRNPFIRYHPYHTSVPELSDLFEWCPPTRSVDLPAAEQEGWDLKDGGAVVEGFEIFRGWVPWDEDLTTWDRERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Y3</accession>
    <name>A0A1Y1U8Y3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vesicle fusion-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_639334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867884.1">
        <property type="nucleotide sequence ID" value="XM_022017220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Y3"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Y3">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Y3"/>
    <dbReference type="GeneID" id="33559029"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Y3"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="779" mass="87742" checksum="8C5284346E2EE138" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9C7</accession>
    <name>A0A1Y1U9C7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21 22">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BD324DRAFT_583173</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868875.1">
        <property type="nucleotide sequence ID" value="XM_022013600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9C7"/>
    <dbReference type="FunCoup" id="A0A1Y1U9C7">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9C7"/>
    <dbReference type="GeneID" id="33555408"/>
    <dbReference type="InParanoid" id="A0A1Y1U9C7"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0010">Activator</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="18" id="KW-0779">Telomere</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="10"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ORX34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="302" mass="33499" checksum="8C07644602726CBF" modified="2017-08-30" version="1">MTISASHHLLDQAMLIKQGAEAKVYSLDSLLPQPTIYWPPSGPSKPSSTAQIQQTTAPKCSVILKYRFKKQYRHPALDLSLTRSRLAFEARALARCTRAGVVVPHVMWVDDRNGVIGMERIDGWSVREVLGGGAEGEMTVEEEDEEEIGEMEMERSKDQVDSINADETESEGWTALRSKGVTKEHLMTSIGRAIAKLHGTAIIHGDLTTSNMMVRFTPNGSEPYEIVLIDFGLSSTATLPEHYAVDLYVLERAFASTHPQSEGLYAGVLAAYAEGLGEKKWRPIQTKLKEVRLRGRKRDMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9I5</accession>
    <name>A0A1Y1U9I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_643537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868445.1">
        <property type="nucleotide sequence ID" value="XM_022017555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9I5"/>
    <dbReference type="FunCoup" id="A0A1Y1U9I5">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9I5"/>
    <dbReference type="GeneID" id="33559364"/>
    <dbReference type="InParanoid" id="A0A1Y1U9I5"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="160" mass="18287" checksum="90E124EA53D50794" modified="2017-08-30" version="1">MTQYTISKGTKEDVAVYEKEPDAVVTNHDQLVENIFNKGYANIFVARVKTEDGSRGEAVGFALYFFTFSTWLGVPGLYLEDLYVKPDHRANGLGKRLFGELGAVAKERGCGRVEWRVLKWNQPSIDFYVKRLKAESLDEWDTMRLEGSEAIARLVQMRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9L3</accession>
    <name>A0A1Y1U9L3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcription initiation factor TFIID 111 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_653502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868512.1">
        <property type="nucleotide sequence ID" value="XM_022018662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9L3"/>
    <dbReference type="FunCoup" id="A0A1Y1U9L3">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9L3"/>
    <dbReference type="GeneID" id="33560471"/>
    <dbReference type="InParanoid" id="A0A1Y1U9L3"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="7">
        <location>
            <begin position="340"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc knuckle" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="808"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117745" checksum="DB85686058DFC0D7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9U3</accession>
    <name>A0A1Y1U9U3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_583980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868592.1">
        <property type="nucleotide sequence ID" value="XM_022013649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9U3"/>
    <dbReference type="FunCoup" id="A0A1Y1U9U3">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9U3"/>
    <dbReference type="GeneID" id="33555457"/>
    <dbReference type="InParanoid" id="A0A1Y1U9U3"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="308"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="623" mass="68365" checksum="C4475BCF54B2A4BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAG4</accession>
    <name>A0A1Y1UAG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_582738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869244.1">
        <property type="nucleotide sequence ID" value="XM_022013578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAG4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAG4"/>
    <dbReference type="GeneID" id="33555386"/>
    <dbReference type="InParanoid" id="A0A1Y1UAG4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF646">
        <property type="entry name" value="HAEMOLYSIN SECRETION ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="276" mass="30493" checksum="F4440584AA1AE37F" modified="2017-08-30" version="1">MKLEVHNLSFTYPGTTKKALRGINLVIEPGEQLAIVGLNGGGKTTLVKVLMGLYDAKGSLSVNDLPIESYDPVSIHKRTSCLFQDFGQYELTLRENVGIGDLRYLEEDAKLELALERGGASEVVTKTGLDGPLDPWYAPDRKQKAQALSGGQWQRVALARAFLKSDDADLVVFDEPSSSLDPKAEAELFQKIHSLSMRGGRKITTIYISHRFSTVRRADKIAVVENGTIIELGTHDELMRLGGRYQELFKLSKDGFEDSYPGRNNQEAPFTSSESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAM2</accession>
    <name>A0A1Y1UAM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_604852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868857.1">
        <property type="nucleotide sequence ID" value="XM_022013989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAM2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAM2"/>
    <dbReference type="GeneID" id="33555797"/>
    <dbReference type="InParanoid" id="A0A1Y1UAM2"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="51649" checksum="B2C6E2B7602222EA" modified="2017-08-30" version="1">MTEQALKGPKASGKVLSNTKTRGEALDRARMDKQVVKAVMVSPLIVPWPSIPNHLQKAVLSSLPTLIPDSIPAYHVDRARCKHFNQAQRRKEKKRQKAAVDKQLEEENHGEDPRLSTPQRPNDNSFRDSQAIGKADDKPAHPPPKIPEAPDVLQHLIFGINETIKVLERSIDDLKLRLMLMADAINGNLQLATTSLPLNSNGLLPTAPSDSSARTQGISMTESLGARLYPPAFIIVPLLSISPQTLVSAIPQYCATYNALVYQWIQLGKIIETRMKKDQRTIIGEPREEIRVVALGDVELEIARMVGLRRVACTAVRSSHPDLKILSELLPKSALHPPRHQITLPHPTSNVRVHCAQRDRGPAQRGQGPGSSAAVPDEAHDMSPLIPEVHYTPLTIKGITTSAPVDGQARKAKRLEEVRARRKVVKERRRAMRLKEMKLGVKGLKVASNLKSKQNGKTRRSKPAASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB05</accession>
    <name>A0A1Y1UB05_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868543.1">
        <property type="nucleotide sequence ID" value="XM_022018668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="33560477"/>
    <dbReference type="InParanoid" id="A0A1Y1UB05"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="152"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="915"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1018"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1074"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1351"/>
        </location>
    </feature>
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            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="166"/>
        </location>
    </feature>
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        </location>
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    </feature>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1294"/>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1404" mass="156800" checksum="D8215E05CF731CDC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB09</accession>
    <name>A0A1Y1UB09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868949.1">
        <property type="nucleotide sequence ID" value="XM_022018586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB09"/>
    <dbReference type="GeneID" id="33560395"/>
    <dbReference type="InParanoid" id="A0A1Y1UB09"/>
    <dbReference type="OrthoDB" id="2563640at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="128" mass="14216" checksum="FD86729F8C835ED5" modified="2017-08-30" version="1">MPRVMKALSCKQAPKPYTKPEADEVPSSGDSGENSHAPRETSKEERSLMPTTEPKGSAKPVNRPWTVEELKVIFHFVVKHGAPGSEQGWEGVVPGRSGAQARSLWRTQLMPRLEDAIKFKAKEHTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB31</accession>
    <name>A0A1Y1UB31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_637434</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868573.1">
        <property type="nucleotide sequence ID" value="XM_022017008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB31"/>
    <dbReference type="FunCoup" id="A0A1Y1UB31">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB31"/>
    <dbReference type="GeneID" id="33558817"/>
    <dbReference type="InParanoid" id="A0A1Y1UB31"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="506" mass="56600" checksum="33C54B4B9FC1433F" modified="2017-08-30" version="1">MATLSEPKDNKDVQASARQRGASTMDFKSATTGVAAKTMRNELNRMVSGVTEPSKKKMFDAEMQSFFLLFNRFLTERAKGEKLDWEKIKAPKPEQVRPYKVLPNVDPAILNKLAVLKLNGGLGTTMGCVGPKSVIEVRDNMTFLDLSVRQIEHLNSEYNVNVPFILMNSFNTDDDTARIIQKYQNHNINILTFEQSRYPRVDKESLLPCPREAASDKANWYPPGHGDIFDAVTNSGLLDKLIAAGKEYIFISNVDNLGAVVDLNIFQTMIDSQAEYVMEVTDKTKADIKGGTIIDYEGKVRLLEVAQVPKDHMDEFCSTRKFKIFNTNNIWCNLKAIKRVMDEDALNLEIIVNNKVTEQGQAVIQLETAIGAAIKHFESAIGINVPRSRFLPVKSCSDLLLIKSKLYNLEHGVLTMDKSREFGGTPVVKLGDHFKKVANFEKRFKSIPNITELDHLTVSGDVWFGKGIRLAGTCIIVANEGNKIMLPDGTNLENKLITGNLNIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBC8</accession>
    <name>A0A1Y1UBC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_653162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868648.1">
        <property type="nucleotide sequence ID" value="XM_022018621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBC8"/>
    <dbReference type="FunCoup" id="A0A1Y1UBC8">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBC8"/>
    <dbReference type="GeneID" id="33560430"/>
    <dbReference type="InParanoid" id="A0A1Y1UBC8"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="42"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="473" mass="50265" checksum="E94E2794860751E3" modified="2017-08-30" version="1">MADAINDPAAAAASASMVVPTEEVKVDLTKLNALSPEVISKQATINIGTIGHVAHGKSSTVRAISGVQTVRFKNELERNITIKLGYANAKIFKCNNPACPPPGNYKSFPSSKDSDPKCERPGCGGTMELQRHVSFVDCPGHDILMATMLTGAAVMNGALLLIAGNESCPQPQTGEHLAALEIIGVDPKNIVILQNKMDLVRQSEANEHYESIKKFVEGTTARLAPIIPVSAQLKFNIDAVVEALCKVAPPNYDFTADPRMVVIRSFDVNKPGAEVDELKGGVAGGSILQGVFKVGMEVEIRPGLITRDANGVCTCRPLRSRIVSLLAEQNHLQFAVPGGLIGVGTLVDPALCRADRLLGMVMSAVGKGPSIYTEVKAEVFLLRRLLGVKTDDSKKAKVTKLVVGENLFVNIGASQTGGRIVALKGGDVTIALTTPACTEKGEKIALSRRIDKHWRLIGWGKVKSGGVLAEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBD0</accession>
    <name>A0A1Y1UBD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_635096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869048.1">
        <property type="nucleotide sequence ID" value="XM_022016784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBD0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBD0"/>
    <dbReference type="GeneID" id="33558593"/>
    <dbReference type="InParanoid" id="A0A1Y1UBD0"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="397"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="74132" checksum="FC7627D5AB0E1222" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCA3</accession>
    <name>A0A1Y1UCA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Malate synthase</fullName>
            <ecNumber evidence="2 8">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_633970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 8"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869342.1">
        <property type="nucleotide sequence ID" value="XM_022016685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCA3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCA3"/>
    <dbReference type="GeneID" id="33558494"/>
    <dbReference type="InParanoid" id="A0A1Y1UCA3"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="9">
        <location>
            <begin position="159"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="11">
        <location>
            <begin position="410"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="544" mass="60428" checksum="418F4AEF0C8D95A0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCB8</accession>
    <name>A0A1Y1UCB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_631038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869823.1">
        <property type="nucleotide sequence ID" value="XM_022016397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCB8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCB8"/>
    <dbReference type="GeneID" id="33558206"/>
    <dbReference type="InParanoid" id="A0A1Y1UCB8"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="854" mass="92864" checksum="26CE490DC7358EED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC0</accession>
    <name>A0A1Y1UCC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_70208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869854.1">
        <property type="nucleotide sequence ID" value="XM_022019222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC0"/>
    <dbReference type="GeneID" id="33561031"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="166" mass="18372" checksum="2D35BB09CA78F0A1" modified="2017-08-30" version="1">MLPPGRLTMFSTRLTHRADNPAPPEPTIAIFMLCMVLSDSQSYSEKAPRHFISGCGVTLKGTDRKASLKLSKAGSQRVFLPVTCPNSYGRGVQRRRRGRSEAKRIWQVKSIKGCIVGSFGDEGDFDRHRQSVERQITIKGSFKYGTLGVLVTSLGGVGVRVERIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD20</accession>
    <name>A0A1Y1UD20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_643119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869181.1">
        <property type="nucleotide sequence ID" value="XM_022017527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD20"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD20"/>
    <dbReference type="GeneID" id="33559336"/>
    <dbReference type="InParanoid" id="A0A1Y1UD20"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="342" mass="36173" checksum="CE5FE8C7B0B82268" modified="2017-08-30" version="1">MSLSYLQHESTPVLPESVWALAWTPLDHIISGSADGHIRVHSATDLSVPLQDAGSHPLAITSLSVTEDGRRSLSTSLDGTVVLFDPLEGRDLDRLDTSREKVDGDRELPAFSCAVHPSMKCWAWSGRSSKIAMRSISQADHAESSTNGDGVGRSLLSGETKLVETGKGKFGMDLKFSPDGQMLALATESGHVIVLDTETQAIIATYQSHAMATRTISWSPDSQWLLSGSDDHLIVIHDVRAGSKSGAGGRGEGAVGMMQGHQSWVLSVAASPDGKLLGSGGADGVIKLWDIGQRTAVYSNSSSAEVWGFDWQPVSANSNASGKQFAIGEDNTVSLYRAAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDF1</accession>
    <name>A0A1Y1UDF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_652820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869321.1">
        <property type="nucleotide sequence ID" value="XM_022018559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDF1"/>
    <dbReference type="GeneID" id="33560368"/>
    <dbReference type="InParanoid" id="A0A1Y1UDF1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="655" mass="72957" checksum="33306546609464BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDL8</accession>
    <name>A0A1Y1UDL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_682390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869780.1">
        <property type="nucleotide sequence ID" value="XM_022019150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDL8"/>
    <dbReference type="GeneID" id="33560959"/>
    <dbReference type="InParanoid" id="A0A1Y1UDL8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="21355" checksum="E53880CDD95B28DF" modified="2017-08-30" version="1">MSNLSQTGSNNEMILDTETDPNGLAVSDEEVENTASGNNVVQATMLDTLTRLSKPAHSVDEFDNLKTTIHTAFMTQHDTQYQQEGLRLKGQGCSLQESKSRAEELWVQILDSERFKDLSQNPSQWNCSEPLVIFRTEPNGSSGEVAGAVTLRLYHKSVPVKTLVLRERIPQMDVYDGSDIDELLGPPPRGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UES5</accession>
    <name>A0A1Y1UES5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_580987</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870623.1">
        <property type="nucleotide sequence ID" value="XM_022013478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UES5"/>
    <dbReference type="FunCoup" id="A0A1Y1UES5">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UES5"/>
    <dbReference type="GeneID" id="33555286"/>
    <dbReference type="InParanoid" id="A0A1Y1UES5"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11600">
        <property type="entry name" value="HDAC_Clr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="76"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="13">
        <location>
            <begin position="432"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="719"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="756" mass="82143" checksum="8FC71628DFEA85AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEU0</accession>
    <name>A0A1Y1UEU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_626414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870650.1">
        <property type="nucleotide sequence ID" value="XM_022015892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEU0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEU0"/>
    <dbReference type="GeneID" id="33557701"/>
    <dbReference type="InParanoid" id="A0A1Y1UEU0"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049017">
        <property type="entry name" value="Nab2_Znf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21803">
        <property type="entry name" value="Nab2-zf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="543" mass="57601" checksum="F4FC6027FB69B109" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF26</accession>
    <name>A0A1Y1UF26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_580489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870687.1">
        <property type="nucleotide sequence ID" value="XM_022013440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF26"/>
    <dbReference type="FunCoup" id="A0A1Y1UF26">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF26"/>
    <dbReference type="GeneID" id="33555248"/>
    <dbReference type="InParanoid" id="A0A1Y1UF26"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="235" mass="26030" checksum="70477FC5305473DA" modified="2017-08-30" version="1">MTSKWVPLEASPDVFNEWSRSLGLPDSPLSFQDLFSLDEEFLQFVPKPVKAVLLLFPQRGKLAEARKEEEERGEGKWDGDVWYIKQTIPNACGSIGLLHALLNLPSSGEYALKQDSPLIHFKTASVPLSPLDRAKLLDKADFFEAAHTVAAQSGQSAVPQGEDVDVDTHFITFIEAENSKGEKRVVELDGGRNGPFDRGLCNDLLKDVAKIVQDKYIAQSDEINFTMLVLAGDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF27</accession>
    <name>A0A1Y1UF27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_460250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870740.1">
        <property type="nucleotide sequence ID" value="XM_022012849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF27"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF27"/>
    <dbReference type="GeneID" id="33554657"/>
    <dbReference type="InParanoid" id="A0A1Y1UF27"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000054">
        <property type="entry name" value="Chromosome 16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="30"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="463" mass="51453" checksum="F9599B055A4612DE" modified="2017-08-30" version="1">MSTNIQDYVEILNAEQYVQVEKLAEHARHGITPKVRGEVWLYLLKVLSADKTSEITSIISMNSLYQSLESDLPSDLQILLTKTALAHHARRFHQPTYAGLISSITAESSRGSNNSKTSAQSAGNGLKMNTTPAQPFDQGNNGAGSWMGNEPSSSSNRSRGSTVASQSRPSGSTSQGHSRDPSGRVHVLEQFSSTASQRSTDHPTDKSERSERSERVERQDRVQRQDWIERTNVGPVDDGTTTLRSQVSRFLPPPPTTPPTRQAYLSTLIEVFGKYHNSQRAKGKDRETRRLSSGLDDTEANWVYLATPFICCLSRPTAIYLGFEKLAERMESFPPLPSQLASLLLLVRQALPELFSFFEDEQVPYVQVAMGWLKSLLSREMWLGDVLRLWDAYLASTDMFALHCYVCVAVLATCKETLEELDGSEVKLMLMDLPPLDVDRLLQDAASLRVSFPLPVPAADDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF92</accession>
    <name>A0A1Y1UF92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_74856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869909.1">
        <property type="nucleotide sequence ID" value="XM_022019236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF92"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF92"/>
    <dbReference type="GeneID" id="33561045"/>
    <dbReference type="InParanoid" id="A0A1Y1UF92"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="204"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="335" mass="37289" checksum="B88E42D1A85B065A" modified="2017-08-30" version="1">MSLPFLELPPLCSTPARPISHSSMINSSTINRTATGQPSLLPLQPLLNSNDANSGRYTLAPLVSNHASANTGSSHHYGKVPVTPGGQMITLPFTPSPTCNIARNANSTFTRTTSCFSIGSNTSNNSTMATPPSDDSADDLPVSPEQSIRLAGLKPPARYPGALPESFSRQDPVPGDESDNEDDESKKQKGAPSQNPWDYMRPLKKKERRRFTRRELEAIETLWWVEKAPNKYQRQRIGAWLGVKTKHITVWFQNKRQESKKHAKEQQETLDKSVKQDLEDTKTETHRPRLHHEPDAARMTRVPVNGDRSPLISFPALNLQLRPSATRFSRLPTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFJ6</accession>
    <name>A0A1Y1UFJ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870909.1">
        <property type="nucleotide sequence ID" value="XM_022018314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFJ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFJ6"/>
    <dbReference type="GeneID" id="33560123"/>
    <dbReference type="InParanoid" id="A0A1Y1UFJ6"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF120">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="632" mass="71433" checksum="B98EA38385230837" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFK1</accession>
    <name>A0A1Y1UFK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_471811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870900.1">
        <property type="nucleotide sequence ID" value="XM_022012879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFK1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFK1"/>
    <dbReference type="GeneID" id="33554687"/>
    <dbReference type="InParanoid" id="A0A1Y1UFK1"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="2">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="3">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="732" mass="78107" checksum="22C9EC56A40A17CF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFM6</accession>
    <name>A0A1Y1UFM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GS catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_651347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870939.1">
        <property type="nucleotide sequence ID" value="XM_022018318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFM6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFM6"/>
    <dbReference type="GeneID" id="33560127"/>
    <dbReference type="InParanoid" id="A0A1Y1UFM6"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="123"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="449" mass="49300" checksum="353784DC33970051" modified="2017-08-30" version="1">MQLDQSGLLSHFLHSNPGIRKIRYQTKTYGNVTLDRFLTVARARQMAAESTIQGQAINVVCQTLRNFATTGHMDMDFEAGDDLWVPDYTTIKRCALYKDYASCMVNVIETQYINSSTPFALCPISTLRKAQEEAKAKGYNLLMGSEIEFYFLTDPDAEEVVPVTGSPLYNTAASRHPVFKVVDEAVDVLEANGLAVWGYHQEGASSKYEISLGPADPVTTIDNMIYASEVIKDLAYKHGYHVTMHPHAFPGKWPTAGQHWHVSVDKEGSKPGDAFLAGLLDHFPSVSAFLRGGYDSYQEGRRFWYGGGPVMWSLGNAAPIRRFGDSHFEARVGDALSNPYLQAAAIIAAGMDGIHSQMPLTMGPCEGRLGAGGSAAERDQKLKTLGVTKTLPETLAAAVKDLKGDNGAWLTYSFGQPLLNAYFKVKEDEAKNSGSMEEAVRRQAILRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFR9</accession>
    <name>A0A1Y1UFR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_627659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870979.1">
        <property type="nucleotide sequence ID" value="XM_022016024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFR9"/>
    <dbReference type="FunCoup" id="A0A1Y1UFR9">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFR9"/>
    <dbReference type="GeneID" id="33557833"/>
    <dbReference type="InParanoid" id="A0A1Y1UFR9"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="124" mass="13233" checksum="ECA2DDDB6476B68F" modified="2017-08-30" version="1">MSAPASNAAAAAASTSRLTRFMNSDVGPKTIFFWAPLAKWGLVAAGVKDLGRPAEKLSVSQNVALMATGFIWVRYSFVITPVNYSLAAVNACVGLTGLGQLYRIWDWRRSNPEAAKLADAARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFX7</accession>
    <name>A0A1Y1UFX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_651654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870515.1">
        <property type="nucleotide sequence ID" value="XM_022018367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFX7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFX7"/>
    <dbReference type="GeneID" id="33560176"/>
    <dbReference type="InParanoid" id="A0A1Y1UFX7"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="90" mass="9961" checksum="A41969123A98C572" modified="2017-08-30" version="1">MTLSSRTSSMRLASTIPGPLAASASAAQNQASKQDAGSDLDTGMLRLRAIKLYKELHRLGRDYPDPEYHFNRRLRRAFESKSTLGASYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGA8</accession>
    <name>A0A1Y1UGA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_673853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871096.1">
        <property type="nucleotide sequence ID" value="XM_022018944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGA8"/>
    <dbReference type="FunCoup" id="A0A1Y1UGA8">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGA8"/>
    <dbReference type="GeneID" id="33560753"/>
    <dbReference type="InParanoid" id="A0A1Y1UGA8"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="36017" checksum="A128AD9BA6608C11" modified="2017-08-30" version="1" fragment="single">AEQETEEEEKDPNRIPDNACETLYLQNLNEKVRIPVMKDTLSLLFKPYHPLLPVIAHRNLRMRGQAFVTFSNIEEANQARKDVAEFPLYGKPIQISFARGRSDSAVQKFEGDEAFEEHKKKRLEEKKKKRRDNPLRRKAAEKMKAGGSLESGAPAAKKQRLQMPDEYLPPNSVLFIQNLPEGTTSDDLREVFELHAGLVEIRTIPAKKDIAFVEFSDEGAATVAKEALHNFKIDGETKMKVCSALKENNLLRNKTLILSAGHICEKVRCTSVFACSQPHGSAQSWQQLVRRSTKIEHLLLDAHKGDTILDASSHELPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGD3</accession>
    <name>A0A1Y1UGD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_630271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870254.1">
        <property type="nucleotide sequence ID" value="XM_022016313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGD3"/>
    <dbReference type="FunCoup" id="A0A1Y1UGD3">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGD3"/>
    <dbReference type="GeneID" id="33558122"/>
    <dbReference type="InParanoid" id="A0A1Y1UGD3"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="6">
        <location>
            <begin position="165"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="343" mass="37133" checksum="A95F0CAB11F67D81" modified="2017-08-30" version="1">MDKTLFVTLLVIFIFVFVIPRLTGRSGKKIEMGPNVTVIQSTAQFDNIVKSLSASQLLVIDFSAEWCGPCHAIAPVFDSLANRYKHVKFVKIDVDHQRLLSSRFAIRAMPTFKFLKGGREIAELKGASPPQLTALVNQHAGPAPPPSATASASASTPQPAAGSASSKPSAPESQSLHSNITSKDLSCLNESSAHPLTSILGTNAGPKGDSYLESDVDAELLLSIPFNEPCKLKAISIFSGVCPSQAPKTIKLFINHLSMDFGDAETLDPAQEITLKPEDVKGDKIDLRFVRFQNVRSLHILVKDNQEDEETTRIDSIDIFGTVGENLDSKAALPRLGDPEDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGG5</accession>
    <name>A0A1Y1UGG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransferase ChoActase/COT/CPT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_630438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870294.1">
        <property type="nucleotide sequence ID" value="XM_022016331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGG5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGG5"/>
    <dbReference type="GeneID" id="33558140"/>
    <dbReference type="InParanoid" id="A0A1Y1UGG5"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="740" mass="82531" checksum="E1A29ECE0BBF8218" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGR0</accession>
    <name>A0A1Y1UGR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_650859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871291.1">
        <property type="nucleotide sequence ID" value="XM_022018221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGR0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGR0"/>
    <dbReference type="GeneID" id="33560030"/>
    <dbReference type="InParanoid" id="A0A1Y1UGR0"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="888" mass="97607" checksum="CE7B2DE3B1E3513D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH10</accession>
    <name>A0A1Y1UH10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871381.1">
        <property type="nucleotide sequence ID" value="XM_022015836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH10"/>
    <dbReference type="GeneID" id="33557645"/>
    <dbReference type="InParanoid" id="A0A1Y1UH10"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="328"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="960" mass="104880" checksum="A72AB024A79FEEB0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHD3</accession>
    <name>A0A1Y1UHD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translational initiation-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_681330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871480.1">
        <property type="nucleotide sequence ID" value="XM_022019115.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UHD3">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHD3"/>
    <dbReference type="GeneID" id="33560924"/>
    <dbReference type="InParanoid" id="A0A1Y1UHD3"/>
    <dbReference type="OrthoDB" id="771227at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="405"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="826"/>
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        </location>
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        </location>
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            <begin position="23"/>
            <end position="41"/>
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        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
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            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
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        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1429"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1455"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1477" mass="160628" checksum="41F6C63793A32A95" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHG2</accession>
    <name>A0A1Y1UHG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_505671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHG2"/>
    <dbReference type="GeneID" id="33554763"/>
    <dbReference type="InParanoid" id="A0A1Y1UHG2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="330" mass="35637" checksum="76628DC71BE83E2D" modified="2017-08-30" version="1">MAPFSPLPPCYPSHVSRPNQSFEPPSRPFAHIFGQTVPAPAGKRRRVAPSSPLILSHPCAPESKGWMVGLALICTLVVVWLVSLPNGEGFERSLEAHESERNGVISGPRRLLDELLNPDDGYDGHHAMIATLEKDKSDGFLPLEGDALNYTSNEAQDKRKITIGNGPEFQPLPFGMILMPSEPTDGSAVFEPDTMNGGPAELEDADAPKAQGLEHRWLELDLPTNDSPWMTERPMDVEETDDSPSSDSETGPTVNDTQGSSYPSLTESSTAVPIDKGSSEPTGTMETLDPVVVLALPGSLRRRSSPHAGRSRRRTGGNKRRAAKSSQAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHW0</accession>
    <name>A0A1Y1UHW0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_622493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871566.1">
        <property type="nucleotide sequence ID" value="XM_022015479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHW0"/>
    <dbReference type="FunCoup" id="A0A1Y1UHW0">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHW0"/>
    <dbReference type="GeneID" id="33557288"/>
    <dbReference type="InParanoid" id="A0A1Y1UHW0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="31964" checksum="8155DBFD9ECB3E1B" modified="2017-08-30" version="1">MAPSFVSDLSGRVKLLDGTTIPQFGLGVYEMNDQETYDAVKWALEAGYKHVDTAEWYENEGAVGRALKEYLGSTNTPRSEIYITSKLMHNRTYESALADLKTSLKTTGVEYFDLYLMHSAIGGPEIRKNVWRALVDAQKEGLCKSIGVSNWGAKHIQELVDAGSPLPVLNQIDLHPFMRHPDIVEICEKLGILLEAWGPLARAKRFDHPSLIKIAESHQREPAQIMLRWGLQHGFIIIPKSVSQKRIVSNAQIFDFELSPEQMKELDGLDEYFVTDWDVVDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI64</accession>
    <name>A0A1Y1UI64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_650781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871212.1">
        <property type="nucleotide sequence ID" value="XM_022018202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI64"/>
    <dbReference type="FunCoup" id="A0A1Y1UI64">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI64"/>
    <dbReference type="GeneID" id="33560011"/>
    <dbReference type="InParanoid" id="A0A1Y1UI64"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="117" mass="12801" checksum="8D2202ADDE9E07F7" modified="2017-08-30" version="1">MSQSGPPAEAKQAQAAALQELDAAQKKKRAIDTSLANLEASIYAFEGSYLEETMATGGNIIKGFDNYLKPPTATVSKKKQDITEGDRLFSTSSVSYMQSLEARKQFEYETLTLAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI74</accession>
    <name>A0A1Y1UI74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sas10 C-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871224.1">
        <property type="nucleotide sequence ID" value="XM_022015768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI74"/>
    <dbReference type="FunCoup" id="A0A1Y1UI74">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI74"/>
    <dbReference type="GeneID" id="33557577"/>
    <dbReference type="InParanoid" id="A0A1Y1UI74"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="584"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="659" mass="73607" checksum="5FCC58F5DC53ADBA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIZ0</accession>
    <name>A0A1Y1UIZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871939.1">
        <property type="nucleotide sequence ID" value="XM_022015647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIZ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UIZ0">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIZ0"/>
    <dbReference type="GeneID" id="33557456"/>
    <dbReference type="InParanoid" id="A0A1Y1UIZ0"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="306" mass="33990" checksum="4FA194B85316DDA7" modified="2017-08-30" version="1">MSRASSSTLRSLAVSSSSRIYAAPTCLPRRSFASQAKPMSGQVSSVDKRVLEGVDGFIPQRNMEVICDWQRGLWSRLQEEVRNNPELLEVKQKWDKSGLDMTYMVSQTAKNQSTALAYNWSALLLNNSFFLENINAYEPQEVPHMYEPLLDKVSAYADGIVGGCWLWLVKAGDKSYDVDIVPTFGSGTFLVSNRAQRGREDLPVFGTPYNSTDTEGAARRDDRPAQAGLGAGSAPNRSVNTNRLMSGGVDYTSFPAPLAVLNLFEHAYLGNKYGVWSRAAYARDWWKTLDWNKIQQRAGRYGGAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ70</accession>
    <name>A0A1Y1UJ70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_622553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871584.1">
        <property type="nucleotide sequence ID" value="XM_022015487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ70"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ70">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ70"/>
    <dbReference type="GeneID" id="33557296"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ70"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115623" checksum="5B2544FCB67EDB15" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJD6</accession>
    <name>A0A1Y1UJD6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_389912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871644.1">
        <property type="nucleotide sequence ID" value="XM_022012658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJD6"/>
    <dbReference type="GeneID" id="33554466"/>
    <dbReference type="InParanoid" id="A0A1Y1UJD6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="335" mass="36769" checksum="DB6CFA59555931E8" modified="2017-08-30" version="1">MTAVQPSPTALYFPHSSQVPHRRPTLSCKPQYQRRPSIHLHQQAQSQPSAPCSRNESISAWQSALLSPSPSPPLVDIRYSTMVPVPEASRKPSEDIVKREYFSPPVYRSPPPLPRLDTATRVNESQETRGPFSNTSTPLRKVRTTPTNGHGFYPTPVSVTERPDAARASGDSRMDHDLPLQYQSASSASQNPTRQAQPPQQQQHQQQHPMYRSPALSPDRPAFFDAHTQQGFPGNLRSTFSPRQTPYLSAHRADSPGPGPQPYATHRPKLSIHPYAPPVNPDARYHSAGASRLALPFGQLTDFYGSPGSAISPGGIKAPLKRGESRSSRGSTLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJN7</accession>
    <name>A0A1Y1UJN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_341421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872121.1">
        <property type="nucleotide sequence ID" value="XM_022012524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJN7"/>
    <dbReference type="FunCoup" id="A0A1Y1UJN7">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJN7"/>
    <dbReference type="GeneID" id="33554332"/>
    <dbReference type="InParanoid" id="A0A1Y1UJN7"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43091" checksum="F5E4E2C9493DD59C" modified="2017-08-30" version="1">MKEEPIPFVPRAGTAEEAEQETVHEVYEAISTHFSQTRRKPWPLVVAFLDSLPRDTIGLDLGAGNGNHLPLATYPPEEHPTGPEEEEKYDLRVAASSQSSDQTLKRTAEARESNARPGRFSIALDHSAGLLKFAKGQLVSGGECIRGEMGFKGWRGGVFDWAINIAAIHHLTTHERRKDAVVAVIRPLVLRSKAPFSRFMLYVWAYEQSSGSKRKMGAAADSTPQAEQGGSHTGSSRHSAPGEEMDASSDMANLAISNVSGADTSSNCTDNHLTNPKIQDVLVPWVYQPPPVKRTDASTTSTETMKDSEKKLYHRYYHLFIKGELSDLVRQAAKEEGFVCVDARPDSLVSACDGGTGARTDALEIGTRWLRIRGEGYEADNWWLEGEVGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJP1</accession>
    <name>A0A1Y1UJP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872202.1">
        <property type="nucleotide sequence ID" value="XM_022015262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJP1"/>
    <dbReference type="GeneID" id="33557070"/>
    <dbReference type="InParanoid" id="A0A1Y1UJP1"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22090" checksum="A349B564189CEC96" modified="2017-08-30" version="1">MRTPYPRVRHIEGYSDEAFNACLKVLTAAFADHPFMLMKNGHDPELLRLDLSIPIASGLQKKLVYVTGHNDHDISAVIIISPPAPPKPSDTTVKTSPQLNSDNEPDYAEKNREEYKAKLPAYIKEYMETVKAEDYKEFVKTIGEELWLGGYRIGVIGTYPSAQGQGYGSALMREIMNMAAEKKSWIALASWTHDTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJR1</accession>
    <name>A0A1Y1UJR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_589530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871693.1">
        <property type="nucleotide sequence ID" value="XM_022013779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJR1"/>
    <dbReference type="FunCoup" id="A0A1Y1UJR1">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJR1"/>
    <dbReference type="GeneID" id="33555587"/>
    <dbReference type="InParanoid" id="A0A1Y1UJR1"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX37706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="433" mass="45757" checksum="2AFE09E5B3A74C79" modified="2017-08-30" version="1">MSKLTTKRHPELLSCNFNQDFSCIAVGHKKGYTILNCDPFGKVHSKNDQGATGIVEMLFCTSLVALVGAADTQPNNSPRKLQIVNTKRQSTICELIFPTSVLSVKMNRKRLIVVLESEIYIYDISTMKLLHTIETGPNPNAVCSLSSDSEHSYLAYPSPSAASTTPMPSTMSVPGPPPAPTTGDVLLFDTISLSALNVIQAHKSPIACLALNSTGTMLATASDKGTVVRVFSVPDAKKLWQFRRGSSSARIWSINFNLMSTLLAVSSDSSTIHIYRLAGPGKGSKGGAMGGGGGGSGDASNDGGERSPTLSEAPSTPVPGSSPPGSGHTATSSLKRRSYHIGKSFVGGVGGYLPRSVSEMWEPQRDFAYIKLRSNQGRTVVAMSGTVPQIMVLSSEGLFQAYNIDLENGGECSLMKEFALLGTDDAGAISGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJT1</accession>
    <name>A0A1Y1UJT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_588643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872242.1">
        <property type="nucleotide sequence ID" value="XM_022013767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJT1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJT1"/>
    <dbReference type="GeneID" id="33555575"/>
    <dbReference type="InParanoid" id="A0A1Y1UJT1"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000020">
        <property type="entry name" value="Pre-mRNA cleavage factor Im subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="241" mass="27381" checksum="AD1752023F0DB749" modified="2017-08-30" version="1">MVDMKIASFDEVIIYPLSHYATVEREAQPEEDTSVPTRVSRLETQYAETGIRRSVDAVMVVLHHGVPHVLTLQVANAFYKLPGGYLDSSETDAEGLITRLNEQLGIPKDHAGQLCGPENPNAAYHMNPSGDWIVKECLSSWWRPNFDTFLYPYLPAHIVEPKEIKRLYLVELPFQKVFAIPQNMSMRAIPIHEFYDNASRYGPQFAGLPYLLSKYWLPGHGKAFKAATEHSVFKQQEPSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJU0</accession>
    <name>A0A1Y1UJU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_620146</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872174.1">
        <property type="nucleotide sequence ID" value="XM_022015252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJU0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJU0"/>
    <dbReference type="GeneID" id="33557060"/>
    <dbReference type="InParanoid" id="A0A1Y1UJU0"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="154"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="328"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="440" mass="47874" checksum="C8D3935397368290" modified="2017-08-30" version="1">MAAESRQAPFDGPWVKRAKGMDEWLQQHKVVASATTASLVSTFTGFPLDSLKSRLQSSRENFPLHRLASEVIREEGVGGLWRGFPLPLLTISIVRTVSFTIYTSTKRILNSEPDLTGGTASLINPATPSSSSSRAQTPWVDVHLGVFNRDTAADVATTSMIAGGASGAVVCIGSAPFELVKVRRQLEYQIYRESHPAAFPQAPAHVPPPNLSLSHHPSGTSASPSTHLPDVAKPIAGPSTVPRPPPFVPPTTLQAVRMIIDTAGPGGLYTGWRLHFLRDTLGTALYFAEYDVMRWFLGRKRVSYGPGKGKGRDEEQGDVPEWARSWLPKGLIPFMCGSVAGVTSWAVIYPVDAIKTKAQLRALSGLPRRTPLHQFLRMVRGPDKDNPKPLITGIARLYRGLGVSMARSMLTHGLLWTIVDLASGYIDTRPCERLAESWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJZ2</accession>
    <name>A0A1Y1UJZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871483.1">
        <property type="nucleotide sequence ID" value="XM_022018256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJZ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UJZ2">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="GeneID" id="33560065"/>
    <dbReference type="InParanoid" id="A0A1Y1UJZ2"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="685" mass="75858" checksum="DFE73A93B09DD436" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK09</accession>
    <name>A0A1Y1UK09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872315.1">
        <property type="nucleotide sequence ID" value="XM_022018044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK09"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK09"/>
    <dbReference type="GeneID" id="33559853"/>
    <dbReference type="InParanoid" id="A0A1Y1UK09"/>
    <dbReference type="OrthoDB" id="2395160at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011988061" description="Polysaccharide lyase 14 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="145"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="398" mass="42395" checksum="4F46FF50EC230527" modified="2017-08-30" version="1">MRRSTSLYTLGLLIASTSSSFATTIEQLVEQWSVTEGNFTFPMPSQSLMKREDAASYLYSAWDLSGRISWGTSDISFVSDPAGSSNSTNARRQVASTTTTSYTHHHHSSSSVLSPSSTAAAASETSSSASSSTSSSSTSSSSSSSSGDTVLRIEYPQGSYSNNTGGTQFNANPLNGTFERMILAYDIYFSSDYQWVQGGKLPGLKGGPETFGCSGGSETDGTGCFSTRLMWRTNGMGEVYAYIPTMSIKNFCSDTGIICNSDYGTSLDRGSFSFVSGQWQTIYLVVVLNEVGVANGVVQLYYNGVQAMNFQNLELRSASSLAGINGMFFSTFFGGSDSTWATPTEQFTYFKNIQLYAGSGESTASGQKIGSASSISSRFSMLPVVTAVVAGCFLTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK56</accession>
    <name>A0A1Y1UK56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nicotinamide N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_577859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872362.1">
        <property type="nucleotide sequence ID" value="XM_022013281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK56"/>
    <dbReference type="FunCoup" id="A0A1Y1UK56">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK56"/>
    <dbReference type="GeneID" id="33555089"/>
    <dbReference type="InParanoid" id="A0A1Y1UK56"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="251" mass="27802" checksum="2D6F17E8EDB6592A" modified="2017-08-30" version="1" fragment="single">PESPLPPPYSFATYTVPADRTLSPLQGGNQIITRLVGSHPLWGHHLWNTARVLTDYLLEHSSLVKGKKILELGAGAALPSLVAALKGANQVTITDYPDQELLDNMQWNVDTNVPLDIRPQTHVKGFLWGADPTPLMNGPEDRYDLLILSDLVFNHSQHKALISSVNSLLSLDLPSNGEMTPCVLIFITHHRPHLADADMAFLPALAESGDGWGYEQVVTEWTGVMFDEDPGDEKLRGTVKGFRAWRRRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK65</accession>
    <name>A0A1Y1UK65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_620889</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872365.1">
        <property type="nucleotide sequence ID" value="XM_022015333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK65"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK65"/>
    <dbReference type="GeneID" id="33557142"/>
    <dbReference type="InParanoid" id="A0A1Y1UK65"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15587">
        <property type="entry name" value="PHD_Yng1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="440" mass="47877" checksum="E63524C28FDE5060" modified="2017-08-30" version="1">MPRKSLPAAASTPQRGPAPQRANTSVKRSTRQASPTPTRPKRRRRGQEHASDEEGEENSASVREVESEDAKPDANGKISLGPEKELEAWQDFAADHYEMIEQLPLELHRTFRLLRELDETCVAQTNDLETVIRRYIAKRMGIQAAERIELETNVPVIESAAPIPDGQGGLLAPPDGAEEGTEEALEVESRRAFPEEGKGQEGDVEMECDAVGQAKDPSADQGKDEEEGKTDTRASELLPDIGRLAREMVRNGEEKVALAVGAYNAIDRHIRALDSALSAHEASILLGLRPDTNPSAAVEPGMVLLDGIGKNPGEDREQVTIGMGGGTARKKKGKKNQATNGASDLPDATTELPGPLFDLEVDPNEPRYCYCNNVSYGQMVGCENDECPLEWFHLGCIGLTQPPTGKWWCNICKPKTDVDPGGGGGQKHKHKRGKGWSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKP8</accession>
    <name>A0A1Y1UKP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_574360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872550.1">
        <property type="nucleotide sequence ID" value="XM_022013057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKP8"/>
    <dbReference type="FunCoup" id="A0A1Y1UKP8">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKP8"/>
    <dbReference type="GeneID" id="33554865"/>
    <dbReference type="InParanoid" id="A0A1Y1UKP8"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46408" checksum="34B2C39A643A70D8" modified="2017-08-30" version="1" fragment="single">MSQSQQINRPASSTDVAPTPQNTPLDTTVLSNRPANLGRPQVEDIGENEEEDGAEEDVSGVNPASLLAKNPALLALAQAKFDELIGRSSGYIESLPASVRRRIDGLKGVQVEHSKIESEFQLAILDLEKKFLEKYTPLYDRRLAIITGKVEPTDEEVEAGKKSDEDSEDEDEEEEGAKIENLDEDGKKAEGDENVQGVPEFWLTALKNHVPISETITDRDEEVLKVLLDVRLSYLSDEKSNGQPGFKIHFTFGPNDFFSDTELTKTYYYQEKVGYGGDFVYDKAIGYDIKWKEDKDLTKKVEIKKQRNKSTGRTRVVRKVVPTDSFFNFFKPPQPPTPETLESEDVDEDELEELDARLETDYQLGEEFKEKIIPRAIDYFTGKALRYEEDYEDEDLEEFDEDDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL00</accession>
    <name>A0A1Y1UL00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras guanine nucleotide exchange factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_650066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018089.1"/>
    </dbReference>
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        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL00"/>
    <dbReference type="GeneID" id="33559898"/>
    <dbReference type="InParanoid" id="A0A1Y1UL00"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="944"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1407"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="328"/>
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        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1416"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1546" mass="169242" checksum="A5724EFA9545EC8F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULE8</accession>
    <name>A0A1Y1ULE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="187" mass="20795" checksum="9F7387CD70BD69E4" modified="2017-08-30" version="1">MSSLLPQYNTRRVSDEEEQRPLNSWKDDDRAMSSPPPPSYPPGRDHASGSGSKNKTITYTFVPRWPVKGKTESVLGLAGGKDATLEMVLRAFPVLNNYPPGRIEFLAAVSPETKLEDVHGWSRIMDEAWDEFTTDAPSRLKIQVADLPGQARRREIRTCAFITLAACSPFAVFALFILIIYLNVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULH0</accession>
    <name>A0A1Y1ULH0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_296794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULH0"/>
    <dbReference type="FunCoup" id="A0A1Y1ULH0">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="GeneID" id="33554218"/>
    <dbReference type="InParanoid" id="A0A1Y1ULH0"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25407" checksum="4184A6740103CCD4" modified="2017-08-30" version="1">MSTTVLISGANRGLGFGLVERYAARDSYTVIATARNPSSMPVVKTGNGSQLIVVEMDQAQVDGPEKMIEQVKSKGISKLDLVICNAAIMTNESFAKIRDIDPKVFEEHWRVNATVRLMEKDGKFIFMSSGAAILDREAEASKPDVTYGITKAGANFLARMAHFEEPHLVIFALSPGWVQTDMGNRAAVLSGREGGKAVISVAESCDGMVKVIDDATRDSMGGKHMRYDSTVSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULZ4</accession>
    <name>A0A1Y1ULZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_679566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872926.1">
        <property type="nucleotide sequence ID" value="XM_022019046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULZ4"/>
    <dbReference type="FunCoup" id="A0A1Y1ULZ4">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULZ4"/>
    <dbReference type="GeneID" id="33560855"/>
    <dbReference type="InParanoid" id="A0A1Y1ULZ4"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="455" mass="49176" checksum="FD2EAA19AEF6F1A6" modified="2017-08-30" version="1">MSQPQELILSACAEASSSSSRPGTTGQPSIYLHDLSTCTQAASLKPSSKNGIGGGVLALQEGKAIVNVWTWQKDQLQLKLHMPEKLSCFTVSPNGCWAAGGSSSGHMYLWEISSGSLHSSFTVHYRQITSLTFTPDSRLLLSSSLDASSHVFLVSQLVDPSLPLPKPYGSFSDHTLPVLSVCVSRSSSVAGGRAFTCSEDGTVKLWDLYPPFTLLSTFALPAGSTPVQVVVDPMERFFYVAANIESRGQAWHVPLYKHKEDARSDNNVEAVGGGGFGEPPVKLGPLIFESKSAFTSMTLSISASHLLVGTDSGEVSILSIPSHQLVRTLNLSGPVTHLSTMLRPPDLGVSNPDRWTPLEVKAFERLRVGKSNREAQDVVMALGPSTKHELLTSLRPPRARGSMARGSGDVHIQKTNEHLAEILDENKRLRASLDKAVKINDKMWKGVVDLHLMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM86</accession>
    <name>A0A1Y1UM86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_577257</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873024.1">
        <property type="nucleotide sequence ID" value="XM_022013247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM86"/>
    <dbReference type="FunCoup" id="A0A1Y1UM86">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM86"/>
    <dbReference type="GeneID" id="33555055"/>
    <dbReference type="InParanoid" id="A0A1Y1UM86"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="16">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="368"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="174"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX39161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="640" mass="69959" checksum="9DCFA337BCC86E6F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMA9</accession>
    <name>A0A1Y1UMA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_312530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873002.1">
        <property type="nucleotide sequence ID" value="XM_022012461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMA9"/>
    <dbReference type="GeneID" id="33554269"/>
    <dbReference type="InParanoid" id="A0A1Y1UMA9"/>
    <dbReference type="OrthoDB" id="2591432at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28716" checksum="D729B17A0CB205A7" modified="2017-08-30" version="1">MASPAAQAPLMPSLYAILSPSFHQTLVSQLSLMAIHSEPYHIQDDMFISTLGQGSTERTLRFRTQTESPPNVTPRQSRINGEIEMNGDLKGKGKGKALDEFPKYSLAYVSPALSGREYGEMNVRAVLGMDVTGMSDRDEIWDFVECLGLRHSHSYTRSGLLFYIPLPHPAFTLRLTITHLIPVDNPSPKTAPSESELGRAPPAQAEFSTKSSKPYIVQLSPSRSVQTVPPRGEPSLVDIMNMMRDVAGRVDMLDWGTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMC1</accession>
    <name>A0A1Y1UMC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_641695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872548.1">
        <property type="nucleotide sequence ID" value="XM_022017439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMC1"/>
    <dbReference type="FunCoup" id="A0A1Y1UMC1">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMC1"/>
    <dbReference type="GeneID" id="33559248"/>
    <dbReference type="InParanoid" id="A0A1Y1UMC1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="281"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="375"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="379"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="498" mass="56444" checksum="E3BDAC0AE9F6DE64" modified="2017-08-30" version="1">MTMRRHLPRNATQSQGPHTRRASRTRANDENAMPSQTLRAKASMSHLGPAQKSNALNASSAPLKKTAAATTATGVKAGAKRTALGGVVSNAQKEDQEDDGKKPVKVKAEPRAPLQSRTNDTNIAQTRPIAPVPHRSKPVTVLASNFEASRIKSEDDVSEMDVDNRRTDDLSTAMPLEVKLDAGESEVEDVSEGEEEDEEEEDDEDWLRATDEEVIAAQEQLALVRSTFKDDIDMFDTTMVAEYADEIFAHMENLEEQVLPNPRYMDFQTEIEWTMRTTLIDWLLQVHLRYHMLPETLWIAVNLVDRFLSVRVVSLVKLQLVGVTAMFIAAKYEEILAPSVDEFVYMTENGYTKDEILKGERIILQTLDFTVSSYCSPYSWVRRISKADDYDIQTRTLSKFLMEVTLLDHRFLRCKPSMIAAIGMYLARKMLGGDWNEAFIYYSNFTEAQLIPGAALLCERLVEPDFESVYVYKKYSNKKFLRASTFARDWAQNNTTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMK8</accession>
    <name>A0A1Y1UMK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transparent testa glabra 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_644852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873102.1">
        <property type="nucleotide sequence ID" value="XM_022017602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMK8"/>
    <dbReference type="FunCoup" id="A0A1Y1UMK8">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMK8"/>
    <dbReference type="GeneID" id="33559411"/>
    <dbReference type="InParanoid" id="A0A1Y1UMK8"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="390" mass="41688" checksum="4FB20EE1D9F7D5A6" modified="2017-08-30" version="1">MASSRLLQYGAQYPLYGVGYSHSTSNPLRTALTTLVTGPTNKLLVVDPTQQAGQDFRQIASVGIGFPATKVGWEPAGLSGYSDSGAELLATTGDVLRIWDLSKDWESNGKGFVGRNGWTEEDHVLRARSVLTNSKSPQMSLPPITSFSWNPVKPSTIVTCSIDTTATLWDINTSQALTQLIAHDRAVYDLAWLPQSPDIFVSVGADGSLRAFDLRQLEHSTILYESSHDTPLARIAFSNSEQHMLACFGMDDNKTLILDMRSPGSPVAELGGHQGALSAIGWGAPGDSPGASSGGWIASCGDDCQVLMYDLCSTLPTPRAPSRNPSSRNSYTLSPPATPSRRSTPSPAPSVDIRPVKAWTADAQVNNLAFSDAGDWLSCVSGSKLTMLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UML0</accession>
    <name>A0A1Y1UML0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_377757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872628.1">
        <property type="nucleotide sequence ID" value="XM_022012625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UML0"/>
    <dbReference type="FunCoup" id="A0A1Y1UML0">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UML0"/>
    <dbReference type="GeneID" id="33554433"/>
    <dbReference type="InParanoid" id="A0A1Y1UML0"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="153" mass="17693" checksum="968D7018B0DF30D5" modified="2017-08-30" version="1">MGGEGWLFLFAVLMAAVLLFTMVFFIIMFSDLECDYINPIDLCNKLNQFVLPEMIAHAFLTLLFLLSGQWLAFILNAPLVAFNVNKIMSKNHMYDATEIFRTLSGHKKESFIKLGFYLVSFFYYLYRMILALISGTSLRWLISLWSTLTASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMW6</accession>
    <name>A0A1Y1UMW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_569374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873263.1">
        <property type="nucleotide sequence ID" value="XM_022013046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMW6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMW6"/>
    <dbReference type="GeneID" id="33554854"/>
    <dbReference type="InParanoid" id="A0A1Y1UMW6"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="109" mass="12787" checksum="BB158F2C4CF8D091" modified="2017-08-30" version="1" fragment="single">PKPIPKTHGILVATLEMHANFVENLEFYSQWCYLSARSFGMPACRPDRLPRTKELITVPKSPFVHKKFQENFQKLTFKRMIRVYDTSPQTLDLWLRYIARNSLGGITMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNE8</accession>
    <name>A0A1Y1UNE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_575469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873375.1">
        <property type="nucleotide sequence ID" value="XM_022013128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNE8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNE8"/>
    <dbReference type="GeneID" id="33554936"/>
    <dbReference type="InParanoid" id="A0A1Y1UNE8"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF1">
        <property type="entry name" value="BNR_ASP-BOX REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013050481" evidence="1">
        <location>
            <begin position="16"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="382" mass="41146" checksum="C1FE68C84381D95E" modified="2017-08-30" version="1">MIHLVALSLTSVALAAPTTGATPWGYFTNNTIMTTSGNASVSYPRFTELQNGSILATTAYRGPQPPYFPIFRSDDGGASWEHVSDLRDQVEGVGFTAQPAITHLTFPLGGYPEGTILAGGNIFGLNFTRIDLYASTDGARTWEFVSHVAEGGRANTTNGATPVWEPKFLPWNNSVIAYYSDQRNPEHGQQLSHQVSYDLKTWGPVVTDVALEPYDARPGMTNIAHVQSVNKWILVHETPIGNSSSYGVNYPVHYKLADTPVDFGPSPDIPLVVNNKTAPNASPYVVWSKDGGPLGTIIVSDADNTGVFTNTAGGDPDKWELHGTPAGAVYSRAVEILRCLPNHLLIYGGDTYDGAMEGAHEPFSVTSVNLEEVLAAPEYSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNF5</accession>
    <name>A0A1Y1UNF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_649140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872910.1">
        <property type="nucleotide sequence ID" value="XM_022017941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNF5"/>
    <dbReference type="FunCoup" id="A0A1Y1UNF5">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNF5"/>
    <dbReference type="GeneID" id="33559750"/>
    <dbReference type="InParanoid" id="A0A1Y1UNF5"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="116"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="421" mass="46052" checksum="7FCE8FAC57FD3BB6" modified="2017-08-30" version="1">MPNHPEEGQFEADPRVHIDKLSGRYQYEDDETGQEFEWSEPAKAWVPVIDEDQWKQQQAAYSVAGVDESTPANAVLAREERIASKRKKDPAAPKVNARASSSKTQAPAQPSAPKNTAVWVTNLPPDTTPEKLASVFSKAGVLMIGDDGEPRIKMYHDDDGRFRGEALVMYFKEGSVSLAITLLDDTELELGAGHGTMKVREAQYGSGAQDTTSSGAGASGSNGQNKAESSSTLAQNGTENGEAKKKKRGPTAEEKQRMTKRIRRMQDKLTWHSDSDSDDAGAPAEGAPKPGANRMNRVVVLKGMFVPADLEKNPALLLELKEDVRDEAETLGTVTAVTLYDKEEDGVMTIKFAEAVSAEACVLKMNGRFFDGRKIYAGIYGGRERYRKSGVGDLDEDSDKEAERLDKFAQWLVDGDEDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNH5</accession>
    <name>A0A1Y1UNH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_644329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873327.1">
        <property type="nucleotide sequence ID" value="XM_022017590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNH5"/>
    <dbReference type="FunCoup" id="A0A1Y1UNH5">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNH5"/>
    <dbReference type="GeneID" id="33559399"/>
    <dbReference type="InParanoid" id="A0A1Y1UNH5"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118729" evidence="10">
        <location>
            <begin position="18"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="529"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="637" mass="69240" checksum="741366C69E8FEEF4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNN5</accession>
    <name>A0A1Y1UNN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_618644</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873010.1">
        <property type="nucleotide sequence ID" value="XM_022015060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNN5"/>
    <dbReference type="FunCoup" id="A0A1Y1UNN5">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNN5"/>
    <dbReference type="GeneID" id="33556868"/>
    <dbReference type="InParanoid" id="A0A1Y1UNN5"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="217"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="547" mass="58850" checksum="2253A1E1299384F9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNS5</accession>
    <name>A0A1Y1UNS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872979.1">
        <property type="nucleotide sequence ID" value="XM_022015048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNS5"/>
    <dbReference type="GeneID" id="33556856"/>
    <dbReference type="InParanoid" id="A0A1Y1UNS5"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="187" mass="20532" checksum="32D46DAB4B11037D" modified="2017-08-30" version="1">MVKKLSPEFINVVSKLFEALPSDGSPIDDEVLMQLHAFFGPMLGSAVQLIDRREVVRVVLPAGRHIYQITSATGSPYTLYAELPARPSVPAVHSSKQDSSLSPDDDESTVPEKAKASPEPQPDNDTSAEQSVQTMAEPSRYSADLVRHSYIRALNRSMQGMYCPCAGYGYNTLAGDRNFLVSHKMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNX5</accession>
    <name>A0A1Y1UNX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_678850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873533.1">
        <property type="nucleotide sequence ID" value="XM_022019016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNX5"/>
    <dbReference type="GeneID" id="33560825"/>
    <dbReference type="InParanoid" id="A0A1Y1UNX5"/>
    <dbReference type="OrthoDB" id="4689996at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012575879" evidence="1">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="139" mass="14788" checksum="AB6811EF5F1B2159" modified="2017-08-30" version="1">MYPSVVATLALAASALPALGLVSNVIAPSTGVCGQNISVTLQGQESLTNNLVFGAAWGVKPASLKNCTSCLGYKAGYQDLSKNEKLPFGRNETFQVEIPDLPNGEYYFVTTIPYEVGESGGVQLRTWNQSFTITGDCMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNY1</accession>
    <name>A0A1Y1UNY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_618739</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873039.1">
        <property type="nucleotide sequence ID" value="XM_022015076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNY1"/>
    <dbReference type="FunCoup" id="A0A1Y1UNY1">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNY1"/>
    <dbReference type="GeneID" id="33556884"/>
    <dbReference type="InParanoid" id="A0A1Y1UNY1"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="674"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="866"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="891" mass="97984" checksum="56F0F4A3C69217BE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP20</accession>
    <name>A0A1Y1UP20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_648372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873527.1">
        <property type="nucleotide sequence ID" value="XM_022017827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP20"/>
    <dbReference type="GeneID" id="33559636"/>
    <dbReference type="InParanoid" id="A0A1Y1UP20"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="65" mass="6955" checksum="1C3C97A65E6D40F4" modified="2017-08-30" version="1">MSRLRESSWASVPIHLRALGLIGSEVIANAAIWTAAGVCFGKEDEILGLALLAWASDGNRSQTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPD2</accession>
    <name>A0A1Y1UPD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nuclear mRNA splicing, via spliceosome-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_619263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873189.1">
        <property type="nucleotide sequence ID" value="XM_022015153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPD2"/>
    <dbReference type="FunCoup" id="A0A1Y1UPD2">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPD2"/>
    <dbReference type="GeneID" id="33556961"/>
    <dbReference type="InParanoid" id="A0A1Y1UPD2"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="316" mass="34228" checksum="61EDDFF33C98FA06" modified="2017-08-30" version="1">MAPSRGTTENLEYPTKQIQLLDAHTGPVNVVKYNNGAKYCLSGSRDRSIRLWNPSAGKEIKCYQGHAQEVLALDIAHDNAKFASCGGDKMVFVWDVAAGTIIRRLQGHFGKINAVAFNQDSQVLASGGFDAKVMLWDMRAVSRDPIQTLKEATSSITSLTIPAKIPEIITGSLDGCIRSYDLRMGKMTDDVVGAPVSSVTPSPTSPKDTLLVSSMDGKLRIFDRANGAVLQTFSGHKVGDMRSKAAWGYGEGLVMTGDEEGRLWAYSVLDAKPIESSPKPIHKRGITWIESKPNGKEMITAGNDGMIKVWAKPDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPU6</accession>
    <name>A0A1Y1UPU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_655414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873028.1">
        <property type="nucleotide sequence ID" value="XM_022018816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPU6"/>
    <dbReference type="GeneID" id="33560625"/>
    <dbReference type="InParanoid" id="A0A1Y1UPU6"/>
    <dbReference type="OrthoDB" id="2594909at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="217" mass="23514" checksum="19F154FEFC6F1BC0" modified="2017-08-30" version="1">MSSADFADPLKGPNGVIGGYGWNVAPCHDALGPERTKRMAAKIEEGRLGKRKKLPKDENAWDNLSSHPSAFLTTKDGKPRLFPFPLGKAGGSQGLRGELWWEAGNAAHVWAKRLSNIKLLMGIIVVGLFHRKAAVVALAGLIYYVFATELAGMLKPKEKDPDDDPPTRRRKVPTTPGMAMTYLYEPTGNGGVREAGSIPVNAPSNRLMTSTDSRYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ02</accession>
    <name>A0A1Y1UQ02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_258163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873896.1">
        <property type="nucleotide sequence ID" value="XM_022012302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ02"/>
    <dbReference type="GeneID" id="33554110"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ02"/>
    <dbReference type="OrthoDB" id="2575946at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="129" mass="14193" checksum="316BB35878A2240B" modified="2017-08-30" version="1">MPATQVGGSSSSLSSSSRFQNEPNATVPPAVAAATSSTLPAKLAKNKRLPATMITPQGQVVPSSKKHAGNVSKKKKRRVEEGKEKALERSGKLEEKVKIREEKRTQLTADRRRNERERRKLGSEVRSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQY4</accession>
    <name>A0A1Y1UQY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_615220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873631.1">
        <property type="nucleotide sequence ID" value="XM_022014695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQY4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQY4"/>
    <dbReference type="GeneID" id="33556503"/>
    <dbReference type="InParanoid" id="A0A1Y1UQY4"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="355" mass="39596" checksum="B107C39E0F9B7B87" modified="2017-08-30" version="1">MATVQSMPGGSDLHHAVDKLVSGSSDPFNIMEHREIFQRRALEDVTINSNDSAMMMNPHNPLLLKEESEAEKATFRKLKYTYIEQGAKVNFVMNITGDEPMGLQPGENEGLQITNKEKKAALKAVKDEVHGVRDEAISLAKDNALRHERVSSQVSEAQALQKKIRDMELELARIKANYPSGKRVTIAQAQDILEQQTEEMQKLITDTEEANKKRDEVREQVSSASKDLQRLMKDKEREEARALEVQSGREAGDTKVDEQCRWLMSSITFYKSLMGIRNVKAVSEYQLHLEYAVPSTTEGDSVVLLLNFDSLSKRLAGAEIMGSDADISEPVNVAVATNDIPGLIADVLVLVRQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR00</accession>
    <name>A0A1Y1UR00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_586539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873360.1">
        <property type="nucleotide sequence ID" value="XM_022013744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR00"/>
    <dbReference type="FunCoup" id="A0A1Y1UR00">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR00"/>
    <dbReference type="GeneID" id="33555552"/>
    <dbReference type="InParanoid" id="A0A1Y1UR00"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="36692" checksum="924E46335380275A" modified="2017-08-30" version="1">MASSSSSALIRSCRQFRSLPSPSSSSSFTFSARPLRSPRPSPTPIQLSFRRCYAASPFPTASEKKLFRPINVLVMLVPFVTFGLGVWQVKRLRWKLDLIDDIQRNIEKDPLVLPPNINLSALPDFAFRRVLLKGKFEGPPLFMGPAVEQGIPGWNIVLPFSRSSTGGSTILVNRGFLTEAKVKAIKDGTDRPPGIKEDGQSEEVVLQGMLTKKWDEGRGRWTPENNPEGNQWFWKDIISMASWVSKENRKVEPVFVDVLDDGKSPLTYMMAQGEPIGRPPTVEIRNQHATYAVIWFTLSVSTAAMTVYLLRTRGRSALKSRPSMRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR24</accession>
    <name>A0A1Y1UR24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_4495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874182.1">
        <property type="nucleotide sequence ID" value="XM_022012813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR24"/>
    <dbReference type="GeneID" id="33554621"/>
    <dbReference type="InParanoid" id="A0A1Y1UR24"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="201" mass="19996" checksum="8B22AD9BF4F792C8" modified="2017-08-30" version="1">MLKFVDRYCNVGCGALDMSNSVFPECCTPLAAGATAPPDCSSVMSSRSAEGTTCPYPTDIGTTDFPDTYSYQPTSSIPQSQAGQSAVASESPVPDGGCASTVWVTSTTTTECSTSCATSEAYSSAAISETSSIDQGMSGIGASASTSSNPPPAPSPTSPPPASSATSEVVVNPSCTPCALSSIPLVQPSEGCLGDSCPSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URC8</accession>
    <name>A0A1Y1URC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_227575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873480.1">
        <property type="nucleotide sequence ID" value="XM_022012227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URC8"/>
    <dbReference type="STRING" id="4999.A0A1Y1URC8"/>
    <dbReference type="GeneID" id="33554035"/>
    <dbReference type="InParanoid" id="A0A1Y1URC8"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="231" mass="25888" checksum="1CEEA42DE5B0B100" modified="2017-08-30" version="1">MSLGVNRLNDRAQKSTISSSYNAIAQKYHDWASPRPTTDRADYIDRLSHILPKDAKILELGCGSGVPATQQCVKLGYDVTGVDVSSKLIEIARREVPGATFHVSDMISFTPPNGERFDCIMAFYTIWHLPPDEEELILRKAATEWLKPGGWLLFNLMTVKGELKMDEWMGQTMISWGLGEDGNRELVKKLVDEGLIEPESKDGTGSQGEIKVEKVGRFDEGMHWFLLQSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URD1</accession>
    <name>A0A1Y1URD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_648769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873952.1">
        <property type="nucleotide sequence ID" value="XM_022017881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URD1"/>
    <dbReference type="STRING" id="4999.A0A1Y1URD1"/>
    <dbReference type="GeneID" id="33559690"/>
    <dbReference type="InParanoid" id="A0A1Y1URD1"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="159" mass="17587" checksum="BCAF2DACA551652C" modified="2017-08-30" version="1">MSFPSSLAGPARSAYRQIIRAARTTFQDDPIHRSQFMSPIRMTFASPTLTPPAHISDPSAKPEEEPCPCNEHPPEPKAAASSSSTHISTEEIAKRISEWKEVALFLRRNVVQGEQDESGSFRLRVTPETELGVNESIRSAERRPKATKEQMAAVFAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URJ1</accession>
    <name>A0A1Y1URJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_647504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874258.1">
        <property type="nucleotide sequence ID" value="XM_022017671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URJ1"/>
    <dbReference type="STRING" id="4999.A0A1Y1URJ1"/>
    <dbReference type="GeneID" id="33559480"/>
    <dbReference type="InParanoid" id="A0A1Y1URJ1"/>
    <dbReference type="OrthoDB" id="2623028at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="60099" checksum="24B9694590D91748" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US34</accession>
    <name>A0A1Y1US34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA photolyase, FAD-binding/Cryptochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_575162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874522.1">
        <property type="nucleotide sequence ID" value="XM_022013109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US34"/>
    <dbReference type="STRING" id="4999.A0A1Y1US34"/>
    <dbReference type="GeneID" id="33554917"/>
    <dbReference type="InParanoid" id="A0A1Y1US34"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="44"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="464"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="64998" checksum="9EE4652F91B36BA1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US89</accession>
    <name>A0A1Y1US89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_574782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874538.1">
        <property type="nucleotide sequence ID" value="XM_022013086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US89"/>
    <dbReference type="FunCoup" id="A0A1Y1US89">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US89"/>
    <dbReference type="GeneID" id="33554894"/>
    <dbReference type="InParanoid" id="A0A1Y1US89"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="34"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="409" mass="45043" checksum="BC445112CA291765" modified="2017-08-30" version="1">MARRAVSAWANVPQGPPDPILGVTEKFKADPSPNKINLGVGAYRDGKGNPFVLPSVKKAEKQLVRAGANHEYLPITGLASFNKLAAELAYGKDSAPLKEGRLAITQSISGTGALRIAAAFLGRFYPESKTIYVPTPTWGNHIPLAKDSGLEVKHYKYFDKSTVGLDFEGMKADIEAAPEGSIIMLHACAHNPTGVDPTESQWKELSEIIKQKKHFPFFDMAYQGFASGDIVKDAFAVRYFVEQGHQLLLCQSFAKNLGLYGERVGAVSFVCADKEEKARVDSQLKIIIRPMYSNPPIHGARIVSAILGDEKLYNDWLSEVKKMADRIISMREKLYTNLVKLNTPGEWGHIKSQIGMFSFTGLTPEQVDKLAEKASIYMTRDGRISMAALNKKNIDYFAKAVSQAVKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT01</accession>
    <name>A0A1Y1UT01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_607336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874120.1">
        <property type="nucleotide sequence ID" value="XM_022014065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT01"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT01"/>
    <dbReference type="GeneID" id="33555873"/>
    <dbReference type="InParanoid" id="A0A1Y1UT01"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="535" mass="59398" checksum="090CF8477E4446B7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT67</accession>
    <name>A0A1Y1UT67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_613657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874892.1">
        <property type="nucleotide sequence ID" value="XM_022014523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT67"/>
    <dbReference type="FunCoup" id="A0A1Y1UT67">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT67"/>
    <dbReference type="GeneID" id="33556331"/>
    <dbReference type="InParanoid" id="A0A1Y1UT67"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="56"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX41213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="300" mass="32344" checksum="9BFDF09700F826EF" modified="2017-08-30" version="1">MTVSEATASAQDMEVDSSSKAESSATAFKRLHPGPYLSKFLAKGYRPDGRKVTAWRDVKINKGSVSTADGSALVRLGDTTMVCGVKAEIAEPLATSPRSGYIVPNIDLPALCSPKFKPGPPADEAQTMSNWLFDLITSSRTVDPQSLCICPGKAVWALYIDVVCINYDGNAFDAAVLAVMAALGNTRLRSATYDDITAKVTCSDDFHSLALGRLPLSCSFGIFKSAYLLPDPSSFEAPLIHTTLTIALDEENRACLVRHEGLGGTDTKSGQDVLDEAWSIAEERVREIRRLLDDHPATNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE6</accession>
    <name>A0A1Y1UTE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_606641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022014022.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UTE6"/>
    <dbReference type="GeneID" id="33555830"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE6"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="826"/>
            <end position="878"/>
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    </feature>
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            <begin position="891"/>
            <end position="928"/>
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        </source>
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    <sequence length="1231" mass="129669" checksum="E01246B0E63EB632" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
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                <person name="Bowen B.P."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
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                <person name="Ramamoorthy G."/>
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                <person name="James T.Y."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">NRRL Y-17943</strain>
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        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <end position="93"/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1UU59_9TREE</name>
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                <person name="Labutti K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="467"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="508"/>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="609" mass="65608" checksum="E64AEC61F43FD1DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUA4</accession>
    <name>A0A1Y1UUA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_19906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874444.1">
        <property type="nucleotide sequence ID" value="XM_022012162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUA4"/>
    <dbReference type="FunCoup" id="A0A1Y1UUA4">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUA4"/>
    <dbReference type="GeneID" id="33553970"/>
    <dbReference type="InParanoid" id="A0A1Y1UUA4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000085">
        <property type="entry name" value="Probable ATP-binding cassette (ABC) transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="305"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="579" mass="62648" checksum="95BBB98B279F53F4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UV83</accession>
    <name>A0A1Y1UV83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 14">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_574406</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 14"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874804.1">
        <property type="nucleotide sequence ID" value="XM_022013058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UV83"/>
    <dbReference type="FunCoup" id="A0A1Y1UV83">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UV83"/>
    <dbReference type="GeneID" id="33554866"/>
    <dbReference type="InParanoid" id="A0A1Y1UV83"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000006">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX41125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="457" mass="50392" checksum="02B88B77192B5291" modified="2017-08-30" version="1">MEHSEGIEKPLAPGKPRKRFVGTSKASSRAPRRIANQIPDDILNDPVLDEAISHLPSNYNFEIHKTVHHIRRDGIKTVALQMPEGLMVYGCAIADIIEEFTGALPLLLADVTYGACCIDDFTAKEMGAEMIVHYGHSCLIPVSQTTLKTLYVFVEIGIDTAHLSLSVRKNFPSSRSAFHRMVLESVDAAKMPIAMDDDSPTRLALVSTIQFVASVQTLRTDLESELPSLDETGENALIKREGNVWRGKYDITIPQSKPLSPGEVLGCTAPKLKDVDALIYVGDGRFHLESIMIANPAIPAFRYDPYSKKFTRETYEHQEMRTVRSDAVRAAKRGLESSGPGSWAVVLGTLGRQGSLSVLKTITSSLPSHDPPLLLLLSELSPVKLALFPDLTAFVQTSCPRLSIDWGYAFDRPLLSPYEASVALGRIKSWSDGDYPMDFYSDNSLGPWTPRHKPIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5R4</accession>
    <name>A0A1Y1U5R4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000023">
        <property type="protein sequence ID" value="ORX33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867708.1">
        <property type="nucleotide sequence ID" value="XM_022017312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5R4"/>
    <dbReference type="GeneID" id="33559121"/>
    <dbReference type="InParanoid" id="A0A1Y1U5R4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="460" mass="49606" checksum="2FAE80C5CD79A612" modified="2017-08-30" version="1">MFAASSSTSTSSASDSRRSESVLEELRRLGWTWTVDKDKVSNFKHPDVQCTHKGETVFQDVPVIHSLDQGGGISTSSCSRHSKSKTACASSHLDVRLFPDADGRLIRRPLQDSDFPDGKWSRDASGRRNKKAARESKRTRGPEVEKADRKRVKLEASRGIAGKSHDSHEVTDPAEDGSTSRSAHARTIILPRLSDDRTRLGPSDDSFGKPASPSSMESSRLASDVDGDAPPSSTVHRRLSPAEIASSLPSSAISREVSATRERSVSSEKSSHHAPGRQEFVASLSIPDTSTETSAPHSITPIAAASSSASSMKRPDEDPAPASASGPPSPSPETPANDEPPPQASSSRLMAERSPATSRPSHSRAVSTSLNEGSTSDKGPATGSLPEAPGVSNHSTASADLNPENHGLSSEQIENNYPPEEDPYLELEWYRLKFPKLMRRLDWLSQEVVRLRRLQAENQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5V6</accession>
    <name>A0A1Y1U5V6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_284753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000023">
        <property type="protein sequence ID" value="ORX33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867711.1">
        <property type="nucleotide sequence ID" value="XM_022012375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5V6"/>
    <dbReference type="GeneID" id="33554183"/>
    <dbReference type="InParanoid" id="A0A1Y1U5V6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="34312" checksum="E5B36C01DF9FABF2" modified="2017-08-30" version="1">MSSPSEAQLPPTSPEAQAPGHAAAITTSTEESKTPPGSPYPWNPKVLEPGNRLDSPLLSSHDPAMNTGETTAQLDPFAISLGKSVANVSVRPSAEGQKASGQQKPKIATNTSEKARPPSTATRYWNSTVVSENRVKEGRLRRALLEKRMEDSKRLREQGLKKAKAMSFTSHIVNGRLEKEVKSKTTIPDKVKQGGLKPVFGSFEGAATKSSKAVISRRAQEESVPMSIKDEAEAAHDSDIKEEADAIPGTGANASATGMGIEQGAHVSEYAHDVSGDLVVKLERIAVSTFSKGQSSSGQSDVRPTFKAVQDAELAGGQGDGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6C0</accession>
    <name>A0A1Y1U6C0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_654010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867871.1">
        <property type="nucleotide sequence ID" value="XM_022018737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6C0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6C0"/>
    <dbReference type="GeneID" id="33560546"/>
    <dbReference type="InParanoid" id="A0A1Y1U6C0"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="426" mass="46416" checksum="769241BDE9CE093B" modified="2017-08-30" version="1">MGPASAIQKDVHLNTAPGSSEDQLKLDPYRPIASTLQRSLQRFLPDDSSLRTQSSLPILMNLDASSYASRVSGKTLILDPHQASSSSSELVSGKKRNRGDPDAKGKARAEHESRAETMTDLGLDGFRKVKTRLGGGVKRGMKMDYNALLPLHYLHTLYLIQLFALLPVPRNLVPYTSTSTQGRSRQTPRLPEGMTNDGITTLLSKAEFTGMEMSIVSSRNSSLVGLKGIVVEETAMTFALVAPDSKVRIIPKEGTLFRVHFPAYAPESSGIVPPPPAQTESSIRRQNKINDQTAANLEAERLNDGTFHTLSQHLAICPRIQIDILGSSFLYRSAERAGRKFRPAQGRGGGSGWGENWVKAEWSEVLQAMEQASKGARQGTTETLVSNECEMDVASGEKGVGATGRKKRNKSRRKDPPAGGSHQVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6F5</accession>
    <name>A0A1Y1U6F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_584838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867901.1">
        <property type="nucleotide sequence ID" value="XM_022013711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6F5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6F5"/>
    <dbReference type="GeneID" id="33555519"/>
    <dbReference type="InParanoid" id="A0A1Y1U6F5"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="121" mass="13588" checksum="88795856B22CDA41" modified="2017-08-30" version="1">MVSSGGQGCMKRVVAFVDVRTAEGDEAGVIFSDMLRSLGARVISRLTDNVTHVIYKSGRQTTLSWWRRQDEETRPFIVGIGWVTKSKEKGEKLDEGAFAVNVEDEDVFSKVSKRERMQEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6L9</accession>
    <name>A0A1Y1U6L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SCO1/SenC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_639089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867968.1">
        <property type="nucleotide sequence ID" value="XM_022017188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6L9"/>
    <dbReference type="FunCoup" id="A0A1Y1U6L9">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6L9"/>
    <dbReference type="GeneID" id="33558997"/>
    <dbReference type="InParanoid" id="A0A1Y1U6L9"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="47"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="9">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="24943" checksum="70CA815B3B007D88" modified="2017-08-30" version="1">MLTDSKPATWKAALLFVATGAGLYFYFENEKEKLRLKKIAEQSTKSIGKPSIGGPFNLVDADGKPFTDQDLRGKWTLMYFGFTHCPDICPEELDKMGAAVDLIEQKHGLGAVLPVFISVDPARDSVPQVKQYIQDFHPRMIGLTGDYESVKRACKSYRVYFSSPPNVKPGEDYLVDHSIFFYLMDPLGQFVDAFGKATSAHEVSVKTMDAMKRWEAAGGNKAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Y1</accession>
    <name>A0A1Y1U7Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_166659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868419.1">
        <property type="nucleotide sequence ID" value="XM_022012071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Y1"/>
    <dbReference type="GeneID" id="33553879"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Y1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="25526" checksum="BAECDACB5C888507" modified="2017-08-30" version="1">MDAPNLADHSGGSAQRSSGPLVLTDAIELIADPRTSQHGASGPPSSATNDPQDQPRSISPVPSYRTYRSRADTFTQQNAPDRAIQQSSTHLIPLTPIKWTRPTLSFIIQNNPREFTYLALLVFILVATMSGWIVFMVLVPGAGLGTAVGADGPNFNTTNQAISIFGLNGLNDNIADSDFNDPFDDIDSADILETGLSGGGSLRRRRDEPPDSDSSDENDGADSGDLGNTALLSVNAGFLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1U855_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868498.1">
        <property type="nucleotide sequence ID" value="XM_022018658.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U855"/>
    <dbReference type="GeneID" id="33560467"/>
    <dbReference type="InParanoid" id="A0A1Y1U855"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="271"/>
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            <begin position="294"/>
            <end position="304"/>
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            <end position="512"/>
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            <begin position="702"/>
            <end position="726"/>
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            <end position="746"/>
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        <location>
            <begin position="805"/>
            <end position="814"/>
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        <location>
            <begin position="815"/>
            <end position="824"/>
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            <end position="841"/>
        </location>
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            <begin position="1100"/>
            <end position="1110"/>
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            <begin position="1784"/>
            <end position="1796"/>
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        <location>
            <begin position="1802"/>
            <end position="1823"/>
        </location>
    </feature>
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        <location>
            <begin position="1824"/>
            <end position="1833"/>
        </location>
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        <location>
            <begin position="1885"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1917"/>
            <end position="1949"/>
        </location>
    </feature>
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        <location>
            <begin position="1952"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="1987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2041" mass="220683" checksum="A357A0482AB912DA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8B3</accession>
    <name>A0A1Y1U8B3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_286293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000024">
        <property type="protein sequence ID" value="ORX33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867702.1">
        <property type="nucleotide sequence ID" value="XM_022012379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8B3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8B3"/>
    <dbReference type="GeneID" id="33554187"/>
    <dbReference type="InParanoid" id="A0A1Y1U8B3"/>
    <dbReference type="OrthoDB" id="10260248at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
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        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP" evidence="1">
        <location>
            <begin position="78"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="35884" checksum="F889435BF1843FE4" modified="2017-08-30" version="1">MVVGYPVSFVTPFLTTSEVLKPDQYHDSNHPHIVSSATVETYGHSHAPMTIRIGNGGLGPSGLVGHLAERFLQDRQLTEQVKFEWVCNHSRHSQVALQAGIVDVAMTYERTEEARAEAEGWSISKGVFCHDHFLLVGPRSNPAGLPSAATIQEALARIAAGNMCFHTRGDGSATMHQEHALWETAGVPFELRSRSSWYVRHPLTPREALVKANEQGAYLLTDRATFLPAVKLGEIQDMAVYVEAGSNMMNSCALGIRSSERRTIVLDFVNWLQEDRAQDILASYAQDWEMGLPLVTPREAPEFVSQHELRHRFAPHSESQSGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Y7</accession>
    <name>A0A1Y1U8Y7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_637992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868292.1">
        <property type="nucleotide sequence ID" value="XM_022017065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Y7"/>
    <dbReference type="GeneID" id="33558874"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Y7"/>
    <dbReference type="OrthoDB" id="2575673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="458" mass="50030" checksum="EE7964D84EB393CD" modified="2017-08-30" version="1">MLSPSFIHDEGGRQRYWKAQNMTPTLFTTGQSRWALQILVVVLSSIALASSAPAIGGGERMYSGAQGDIRGLTVILASVGIGGVGILRGLSLSLPRPWRIYLDRIEFSLITMLWVCWTSATMAFCAFILRRGMCSLSVSEVDLPTCPLLTFELALLHFISVSCLALLLVILTTVTAPTYLFSLSPSVDDSSEEAQDPESVGIFVMWDLALASPPPSPRIKPSAPNYGATLTDRPSNPYAEIPVAKKDKFADGRVMLYLPLLLGGVGVALGTVWTMIVTRYVVVTGFILSVGILTTVFSASFLAIHYRQRREKSNDDAWILRHDRAMEVGSAGALFLLWPLSAIIYTLFPPTPNRPCMNPATSLDSPLDLPKTRTEILCVIASVTISIAWMASWIILWRIMGLAFPMPEVGRTPSFTGTDEERSLLRSGEMPAPAPRPQVKYGRLVAGEVFELGDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9G0</accession>
    <name>A0A1Y1U9G0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_634347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868894.1">
        <property type="nucleotide sequence ID" value="XM_022016719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9G0"/>
    <dbReference type="GeneID" id="33558528"/>
    <dbReference type="InParanoid" id="A0A1Y1U9G0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="89" mass="9631" checksum="FE580B1DDD75F7F8" modified="2017-08-30" version="1">MNLLRLACVGHGLTSSTAALHVKVTDSPGLGVRFYPGVAENHLSSLSRREGGCGISRAEKWNSHQDPSLPLPLPRPVHHSLMSNRRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Q4</accession>
    <name>A0A1Y1U9Q4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tim-barrel domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_653504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868514.1">
        <property type="nucleotide sequence ID" value="XM_022018663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Q4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Q4"/>
    <dbReference type="GeneID" id="33560472"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Q4"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="2">
        <location>
            <begin position="151"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="4">
        <location>
            <begin position="502"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="782" mass="89642" checksum="008900DF10651B5A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA04</accession>
    <name>A0A1Y1UA04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_683292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869101.1">
        <property type="nucleotide sequence ID" value="XM_022019179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA04"/>
    <dbReference type="GeneID" id="33560988"/>
    <dbReference type="InParanoid" id="A0A1Y1UA04"/>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012237350" description="Tyrosine-protein kinase ephrin type A/B receptor-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="33580" checksum="7F7AA3D29AA095F0" modified="2017-08-30" version="1">MLSFAQTLTCLSLLALTVSRAVPGSETHPVKRTFCALIGCDVNQYCTEFGCVTCDAGSSPVQEGGLLCSPWFDLGSAPSSTTQQSSSPTSGWSWKKSTVDERTFFCTGYCQSCPAGTYSSDGSPCQQCPWGETSQQGASSCYPIPSSNSPSPSSTSSTMSPITSTTSEGPRPTRSSSHMVTPTSRSSSSSTPSPSTTSTKTIHSSAASSSAKSTNKTSTVVVLSSSTKSIQSSAISTKSDQSSTHSSKPAQSSMPSKSLQPSSASSAAPSQSSIPCGGGKVESGKCVCPGCSTLINGQCTCPWGQELWNGQCVCPSGQHLKNGQCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA36</accession>
    <name>A0A1Y1UA36_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_582709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869127.1">
        <property type="nucleotide sequence ID" value="XM_022013576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA36"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA36"/>
    <dbReference type="GeneID" id="33555384"/>
    <dbReference type="InParanoid" id="A0A1Y1UA36"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000193">
        <property type="entry name" value="Glycogenin glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="837" mass="91595" checksum="10B103DD48864893" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA93</accession>
    <name>A0A1Y1UA93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_635878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868689.1">
        <property type="nucleotide sequence ID" value="XM_022016843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA93"/>
    <dbReference type="GeneID" id="33558652"/>
    <dbReference type="InParanoid" id="A0A1Y1UA93"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="222" mass="24391" checksum="B257D553D9641B04" modified="2017-08-30" version="1">MTAHSDHNSSAYSHPLSHDDEHFTVAASSPSDVTSHEDTPKHQSPNNGSPSEDPPQYTDCQDTSRPSRIDGLLLVSCDVDSTEIFEEPKRIFGIKISSGKVPTGVSTFTPRFRTRSLIHSLGTKYFDEEEGIPQQMYDHDMQPRTARSEEQDAVAANLRKMTEKVLSATKPQSTNVLWSKVIPGGTFDDLSGHCDEEALKTLGWDYDLASDPVSFSSGCSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAA6</accession>
    <name>A0A1Y1UAA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_108909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869179.1">
        <property type="nucleotide sequence ID" value="XM_022011925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAA6"/>
    <dbReference type="FunCoup" id="A0A1Y1UAA6">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAA6"/>
    <dbReference type="GeneID" id="33553733"/>
    <dbReference type="InParanoid" id="A0A1Y1UAA6"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17666">
        <property type="entry name" value="PTP-MTM-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="865"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="425"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="956" mass="106339" checksum="95DA41F115E6482A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAA9</accession>
    <name>A0A1Y1UAA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_633405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869184.1">
        <property type="nucleotide sequence ID" value="XM_022016621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAA9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAA9"/>
    <dbReference type="GeneID" id="33558430"/>
    <dbReference type="InParanoid" id="A0A1Y1UAA9"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="121"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="261"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="46337" checksum="1B7CA133ED2003ED" modified="2017-08-30" version="1">MRRGLSSLYNLSSQRFTSTSTKVTSLRTSRMAYPSTSSSPSEILSILPDKFESARMSGELFYFPSTAKNVQSSGRRFNICCSPALLNKEKAKADILASVASESSPDHKRQRIEKQNNDGGADQSSGHKSLQNPTEPFKPPYSPDLYVGHLEGIDGEPGMSILLNKYAVLRDHILLCPTSYEPQNLPPSPSQLALAYLFLLAASRHTKPRRMMGFYNGGPVAGASQKWRHIQLIEVPDGRAPVEDWVQSMRFESDDEPLILPHVPYLHIVHSLSKLRHLPFSLSANDLEQVVEILAPALMRCLDLVFQALRVGKVEGETGWNLLLTLDHLHLIPRTKADYQLSAPHTTHVDLNACAYAGLFLVRSEEEDQTLLQAVEPQGGLDVVLRHCGVSREHGEQAIEAMNAHKGMLEDMQQLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAK0</accession>
    <name>A0A1Y1UAK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial alpha-L-rhamnosidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_604875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868383.1">
        <property type="nucleotide sequence ID" value="XM_022013991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAK0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAK0"/>
    <dbReference type="GeneID" id="33555799"/>
    <dbReference type="InParanoid" id="A0A1Y1UAK0"/>
    <dbReference type="OrthoDB" id="6503935at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF2">
        <property type="entry name" value="B, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="1">
        <location>
            <begin position="380"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="807" mass="92151" checksum="8F36E220BC24B15A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAL9</accession>
    <name>A0A1Y1UAL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_636388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868820.1">
        <property type="nucleotide sequence ID" value="XM_022016893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAL9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAL9"/>
    <dbReference type="GeneID" id="33558702"/>
    <dbReference type="InParanoid" id="A0A1Y1UAL9"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="311" mass="32547" checksum="686A691768F7DB90" modified="2017-08-30" version="1">MMTTTIDDQDPKLAWYGASCLSGAERIITDDTKSDLYYDAGLPHGLTADMPPSHGSTGNGEYCIIAWHGTDIAGIYGISVDGQDAQFYSGYASSDTFQQVLFATSGLAEGDHTIRLSNENARNTEQYPAYIWFDVDYAVFTGTLMDASSTANVPGPTTSTTPITSSSIATSTSTQQSSSTDAPPSSSTSFDSTPSTSTSASSSTSPSALSGFSLYPSSSRRLNGVGGPTSNQPQTSGTPVVPTTTGQPSSSVSSGSDNQDSGKTSNRTTAIAVSVTIIVVAVVVIATVGILWFLRRKRRRREEQEETNGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAV1</accession>
    <name>A0A1Y1UAV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_582456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869384.1">
        <property type="nucleotide sequence ID" value="XM_022013559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAV1"/>
    <dbReference type="GeneID" id="33555367"/>
    <dbReference type="InParanoid" id="A0A1Y1UAV1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="530" mass="56985" checksum="72C07246D56EE2F1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAV9</accession>
    <name>A0A1Y1UAV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_634332</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868888.1">
        <property type="nucleotide sequence ID" value="XM_022016715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAV9"/>
    <dbReference type="FunCoup" id="A0A1Y1UAV9">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAV9"/>
    <dbReference type="GeneID" id="33558524"/>
    <dbReference type="InParanoid" id="A0A1Y1UAV9"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="43136" checksum="3F0544EDFB41FC18" modified="2017-08-30" version="1">MTRTSHRAHPTTSFPVYCLDWADDQTLLMGGGGGASRSGIENKLKACKVSKDGRNVKYTTELRLSSEEDAPMTMAVDRKSGQLVTGINSAEASVKAGSNEHCRVYSYQDEFALVRGRKTIEAEWSDDYPYQKITCLSPSFEFVAVGTTTNSGTEGQVAILRFPELEPVHVLRPDGELVDVDWGGADGDWLAITTTSALLLYRVKEGEKSDRKFELKQTISPPSLDANPVIYRSARFSQDSILHAILNVSKVKNRGAPKKSFVVNYGLAPLPEDGKGKEKATDLDQWDIITRREVASKQITVFDVSGNGKLLAYGCADLSVGILDAKTLSPLLKILHAHSFPPTALRFNPSATLLVSASADHTIRAIVVPASFDGLSMTVILLVALLTLILALLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBK3</accession>
    <name>A0A1Y1UBK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869611.1">
        <property type="nucleotide sequence ID" value="XM_022016557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBK3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBK3"/>
    <dbReference type="GeneID" id="33558366"/>
    <dbReference type="InParanoid" id="A0A1Y1UBK3"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="425"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="578" mass="62851" checksum="CFDDAE36AC23CBFF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBM1</accession>
    <name>A0A1Y1UBM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubby C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869633.1">
        <property type="nucleotide sequence ID" value="XM_022016566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBM1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBM1"/>
    <dbReference type="GeneID" id="33558375"/>
    <dbReference type="InParanoid" id="A0A1Y1UBM1"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF161">
        <property type="entry name" value="TUBBY C 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="199" mass="21415" checksum="B9779A2F23D6C895" modified="2017-08-30" version="1">MALAPVNPPLGVFQHYYAGRPTTLVLKEKIMSWTGDDFSVKDTDGNVVCRCSGQAFSLRERKIITDPNGNELFHLRKKQLAIHSTWIGEDAGGSEIFAITKHFSLGTKMRAKFTNVSTGARETISIRGGILSQSADITIGEDGSGPAVARIERKLFSLGEWAGQQTYTVTVAQGVDLALIAAICICFDEAKHEASAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBP9</accession>
    <name>A0A1Y1UBP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_683449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868768.1">
        <property type="nucleotide sequence ID" value="XM_022019187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UBP9">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBP9"/>
    <dbReference type="GeneID" id="33560996"/>
    <dbReference type="InParanoid" id="A0A1Y1UBP9"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="279"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="39745" checksum="0CAEC7EDBFE0C19F" modified="2017-08-30" version="1">MRPLSLDEYKRYGRQMIQSEWGLPGQLKLKRATVAVVGAGGLGCPVLQYLAGAGVGTIRIVDHDEVDVSNLHRQVLHTTDRVGRNKAESAAMAIEALNPHVKAVSIPKAVHNNNAIELLSGIDILIDCTDRPETRYLLSDTAVRLDIPLVSGAAIASSGQWAVYGGVMNGKRRACYRCMWPAVIGDGGGRCSDVGVWGPVTGMVGCGMAGEAIKEILGHGDGYMHMMRLGTPLRSIKLRSQRPTCSCAGGEAPEIRVGECSTKTTTAVERVSPKELHAIQDSVTIVDTRPPTEFGICALESSHNVPLADILAHPDEMTRRYPGQIVFVCRQGNDSLLAAEKVQEAGGTVKDLRGGLVAWSRDVDPEFPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBR3</accession>
    <name>A0A1Y1UBR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tubby C-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_99333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869632.1">
        <property type="nucleotide sequence ID" value="XM_022019295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBR3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBR3"/>
    <dbReference type="GeneID" id="33561104"/>
    <dbReference type="InParanoid" id="A0A1Y1UBR3"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="187" mass="20512" checksum="FC04B5EF2AD6B2A0" modified="2017-08-30" version="1">MSFAIPPVNPPLGIFQNYYAQQPTTLLLKERIRSFTGNDFGIKDVNGNVVCICKGKVMSMRDRMDPMGNVLFHLRLKLAAMLPLWKGEDASGNELFEVSRTWSFRPKVKARFINAATGAPTVISVRGGYLAMNADLAIGEEGEGPMVGHIDRVLFAKSQWGGAQTGVDLSLMAAICICFDEITQKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBU7</accession>
    <name>A0A1Y1UBU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_632979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869662.1">
        <property type="nucleotide sequence ID" value="XM_022016581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBU7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBU7"/>
    <dbReference type="GeneID" id="33558390"/>
    <dbReference type="InParanoid" id="A0A1Y1UBU7"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="184" mass="20351" checksum="4657FDD27C01F904" modified="2017-08-30" version="1">MAFGSSSILSLRLTRDGLLGKVKSIQGQTRAFSKSAFHGESSSSGSSSKRSRTELLPDFNPFHKTIIRRPKSPPTDGPSNLLTPLHNHHGTSTSARGYHIVRPLSGDYPVYTKIRKGGHWTTIIKGVRGNVEAFQQDLNAYFKATHIDPLKVPSRAVLRPTNLHLVMKGKMAGQIVRWLKSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCB7</accession>
    <name>A0A1Y1UCB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_634094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869380.1">
        <property type="nucleotide sequence ID" value="XM_022016704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCB7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCB7"/>
    <dbReference type="GeneID" id="33558513"/>
    <dbReference type="InParanoid" id="A0A1Y1UCB7"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="35320" checksum="6DEF2D9BD4852A7E" modified="2017-08-30" version="1">MSRAAVHSCTLNTGAKMPAVGVGCWFQRPVEAENQETYDMVANALKYGYRHIDTAFGYGNEQAVGKAVRDSGIPRQEIFVTTKLTNSYHGKVQQGFEESFKALNIDYIDLFLVHWPQGEDPETGKTIPKGQSPTFVDTWKNMEKLVGPRCKAIGVSNFSVKNLEILLKEAKVVPAANQVESHIYLPQASLDKYCKDKGIVLTAYSPLGQPASGKSSPILDEPLVKELAKKYDTQPGTILISWVAQRPNWNTVPKSSNPARLKANFEIVKLDQADHDALSAIHKESGKTTSLVDYAEKMKKERVVFGWSVEDMGWENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCN2</accession>
    <name>A0A1Y1UCN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869464.1">
        <property type="nucleotide sequence ID" value="XM_022018487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCN2"/>
    <dbReference type="GeneID" id="33560296"/>
    <dbReference type="InParanoid" id="A0A1Y1UCN2"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118721" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="235"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="353" mass="37346" checksum="B8980BA7381EDEA4" modified="2017-08-30" version="1">MPVVIVLAALIWSSGSALAQTYGDDLSPVLTVCDQSAGQQMSAEVGTTKDFAGLSSSGQCTTATTTPDNNYEFCPNPFLISFIADSTSDNRFECTESLAEYCGASDSTTNNCPTGTECIYTTDYADDSTFWSCGVVCGYEGDSQICSDAGAKLLNGNYVTYCDTISDQCGICSSANELQPGNTDTGGCATPVSAYPATSSGTWRKRAQMKALDMASVENLGCPTGTKKCGTEDSFECVDVMNDLHSCGSCPNEGGIRCDTLPGIIMGDITCQAGLCTSTTCAEGYELWERSCVLPSVAASFREIASRSPTPVSVEELSIQKKKAESENAFSYPIANRKDVAIKHWQTVEIIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD53</accession>
    <name>A0A1Y1UD53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_602546</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870117.1">
        <property type="nucleotide sequence ID" value="XM_022013947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD53"/>
    <dbReference type="FunCoup" id="A0A1Y1UD53">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD53"/>
    <dbReference type="GeneID" id="33555755"/>
    <dbReference type="InParanoid" id="A0A1Y1UD53"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX35988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="509" mass="54614" checksum="F5769D253A1788A2" modified="2017-08-30" version="1">MFFCAISGSPPTVPVVSKTSGTVYEKALIERYIDENGTDPISGEALTREDLIDVKAKPSTLPPRPANQTSIPALLTALQSEYDGIMLESLEIKKSYQSSRQELANALYREDAATRVIARLMKERDEAREALTSLQKTMGFAPSQPAAAEASEDVEMPAERAEGALPSEVESKIMETNQALSSVRKKRKAPAGYATPDQVKSYAQINHVPSLHATKPPGISALDVASNGKTILTGGADKVVQVFDLEESKVVGTLKGHTKPITHVAFREDPNGLLALSASADKHVRVWGEDGGKWGSKANLGGFKGDVTGLAVHPSGAYVAASSTDSTWQLFDLETAQSVMTYSAVPGIDGSFSYASFQVHPDGVLHAGGTKEGTVRVWDARQSSSLAATLESHPSDLTTLSFSENGYYLATGSSADPTINIFDLRKLSILSSWKLPAENQVSEVRFDKSAQFLSVAGTDLRVYANKTWDELLKFEENAGLLTGARFVKLGSEIVTSGMDRTVRVLGTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD68</accession>
    <name>A0A1Y1UD68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_651871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870091.1">
        <property type="nucleotide sequence ID" value="XM_022018405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD68"/>
    <dbReference type="FunCoup" id="A0A1Y1UD68">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD68"/>
    <dbReference type="GeneID" id="33560214"/>
    <dbReference type="InParanoid" id="A0A1Y1UD68"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="507" mass="53254" checksum="D398A66C25CED66B" modified="2017-08-30" version="1">MSSSGKRSFHSSASSSASAKDPYNVLGVKKDSSASDIKKAYYQLAKKWHPDSSKEPGANEKFVEIQQAYDILSDETKRQAYDRYGEASTQEGFDPNAFAGGAGGFGGFQDFGSAFGGRPGSAGDLFESLFGGAFGGGGPGGPFSAGGRGRPMRGDPIEVAVQISFLEACNGASRKLNITPVVDCHTCSGSGLKTGQKRTQCTTCRGTGSQTFQVQGMFMSTTCQTCGGEGSSIPRNARCGDCEGVGRVKEKKEVVVDIPAGIEDGMKIQIPGMGDMPLSASAGGSRGDLNVRVNVKASPIFRRQGTNLYHDAKVPLHVAMLGGRVRIPTLEGDVEVKVREGTQNGEEAVMKGRGVKSLVGGRLDRERRGDLIISWRVQIPRSLTTFQRKILQAYADDVSGLTPNISFDVPPPSTPEQPLRGTTTNGMPSSQQHSSTSSYRPSSSSSSSSSSPSSSSKPSSTSEADLQWPDHTSDKHDDSLAGKAASAIGGALGWVDRLLGGGSGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDD0</accession>
    <name>A0A1Y1UDD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_651938</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870162.1">
        <property type="nucleotide sequence ID" value="XM_022018417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDD0"/>
    <dbReference type="FunCoup" id="A0A1Y1UDD0">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDD0"/>
    <dbReference type="GeneID" id="33560226"/>
    <dbReference type="InParanoid" id="A0A1Y1UDD0"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000008">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="52"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="251"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="455" mass="50641" checksum="A265BD0DFB99F3EF" modified="2017-08-30" version="1">MPAGSVREIVHLQTGQCGNQIGAKFWEILSDEHCIQPDGSFKGTSDIQLERINVYYNEAAAGKYVPRAVLIDLEPGTMDSIKSSKLGSLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRREAEGCDCLQGFQITHSLGGGTGSGMGTLLISKIREEYPDRMMCTFSVVPGPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLASPKYEDLNHLVSLVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTAWGSASYRSVSVPELTQQMFDAKNMMAAADPRHGRYLTVMCIYRGKVAMKEVEDQIQAVQTKNSGYFVEWIPGNVAAAQCDVPPRGLKMSSTFICNSTSIQSLFKRIGEQFSAMYRRKAYVHWYTGEGMDELEFSEAESNLQDLVSEYMQYQEAGADDEMYEEEMPVGEEELEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDK9</accession>
    <name>A0A1Y1UDK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_646197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870259.1">
        <property type="nucleotide sequence ID" value="XM_022017621.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UDK9">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDK9"/>
    <dbReference type="GeneID" id="33559430"/>
    <dbReference type="InParanoid" id="A0A1Y1UDK9"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1856"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2027" mass="219133" checksum="E9842764ADBB9D66" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDV0</accession>
    <name>A0A1Y1UDV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_582139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869445.1">
        <property type="nucleotide sequence ID" value="XM_022013544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDV0"/>
    <dbReference type="GeneID" id="33555352"/>
    <dbReference type="InParanoid" id="A0A1Y1UDV0"/>
    <dbReference type="OrthoDB" id="3353982at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="78263" checksum="95A375143C8AAD4A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDX2</accession>
    <name>A0A1Y1UDX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small-subunit processome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_631336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869870.1">
        <property type="nucleotide sequence ID" value="XM_022016422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDX2"/>
    <dbReference type="FunCoup" id="A0A1Y1UDX2">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDX2"/>
    <dbReference type="GeneID" id="33558231"/>
    <dbReference type="InParanoid" id="A0A1Y1UDX2"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="317" mass="36129" checksum="91244C9EB69A85F4" modified="2017-08-30" version="1">MVKPTLKSTFARRNHKERAQPLHRQRLGLLEKHKDYVHRARDYKSKQDRIKKLREKAAFKNKDEFYWGMVKGKTKDGVAIADRGNEALSVDVVKLLKTQDAGYIRLQIAKDEKTIGKLRRELEVTAPGASSSEWDAAAELAEVEKLAEMGVVLQPRESQSSKRKGKGRAPPTGHVLFADGRDEFEAESSTALRPMVTSTDTGSEQEPLDLGWVNDTPKQKTKPQKEPTVDPEPNAEEEARAHRMSLLTSLSAHLNRIKQLRQAEQKLQATKSLMGKGAARKVRNAGWVEDDSQHEDRNGERKRWEGKVWKWKLERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE57</accession>
    <name>A0A1Y1UE57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_651570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870431.1">
        <property type="nucleotide sequence ID" value="XM_022018355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE57"/>
    <dbReference type="GeneID" id="33560164"/>
    <dbReference type="InParanoid" id="A0A1Y1UE57"/>
    <dbReference type="OrthoDB" id="10258744at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010342">
        <property type="entry name" value="DUF938"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20974:SF0">
        <property type="entry name" value="UPF0585 PROTEIN CG18661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06080">
        <property type="entry name" value="DUF938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="243" mass="27164" checksum="29AB311CDC522913" modified="2017-08-30" version="1">MAYPNINSIPGTQQRNLGPVTEALLPLVEELLAVYSDSEVTPRVLELASHPYTHILSWAKRWPSVEWWGSARDTEQIRDIEAVLGSTPTDDRPPSNLRHPIRLDIQSESDWTNLRALLDGQSIQLGGVIMLNLIHCCPLGVPEEIFKHLSGDISSSDVDESLLHSSSSWVAAYGPWKNDDGTYKSDADKAFEESHIRSSDPSLGLRSIQSITSMAERHGFIEDKRVKMPAGNVFVVWRRRVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE75</accession>
    <name>A0A1Y1UE75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_628440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870451.1">
        <property type="nucleotide sequence ID" value="XM_022016119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE75"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE75"/>
    <dbReference type="GeneID" id="33557928"/>
    <dbReference type="InParanoid" id="A0A1Y1UE75"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="58"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="322"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="589" mass="63001" checksum="2ED7742EA1D15D26" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEQ5</accession>
    <name>A0A1Y1UEQ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870609.1">
        <property type="nucleotide sequence ID" value="XM_022018385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEQ5"/>
    <dbReference type="FunCoup" id="A0A1Y1UEQ5">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEQ5"/>
    <dbReference type="GeneID" id="33560194"/>
    <dbReference type="InParanoid" id="A0A1Y1UEQ5"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="266" mass="29226" checksum="D217C57A2BF66023" modified="2017-08-30" version="1">MSKISPTVLQNYVAEGDQANLFSTVDFGELTMLTRPPIFIPRAETAYIMDHLADILLEHPVMSTLERPLRILDLCTGSGSLALMLAHRLRSKAHLTAVDINPEAVTLARENAALNGLTSHVDFVVQDFTTSDLGEASFDLVVSNPPYIPHGEWETLSPSVKDHEDPRALIGDPQDFPAQSREHPISESSDGQGLYFYRKIAQKLPLFCKSSILRQSRGLPLLAVECGATQADDVQHIFKTQTSGLISSTTVVKDQFGQDRMVIGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF87</accession>
    <name>A0A1Y1UF87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_681488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870789.1">
        <property type="nucleotide sequence ID" value="XM_022019122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF87"/>
    <dbReference type="GeneID" id="33560931"/>
    <dbReference type="InParanoid" id="A0A1Y1UF87"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="103" mass="11171" checksum="08ED85069A205600" modified="2017-08-30" version="1">MSVTAPIFDKADPKSKQLFPYHLPLTQEWAEEKSFFGNTMMMGSGAGMFLKNPLIVYAALIISVITLVGSSPLRAPKDMQSPLMGIGLGLMGLITVNLPRLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF93</accession>
    <name>A0A1Y1UF93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_608784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870782.1">
        <property type="nucleotide sequence ID" value="XM_022014121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF93"/>
    <dbReference type="GeneID" id="33555929"/>
    <dbReference type="InParanoid" id="A0A1Y1UF93"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="109" mass="10841" checksum="5BAFD70191FF8AB8" modified="2017-08-30" version="1">MSTSATAPVPASSAQCSCSNKTDGQTCGCQQAGECQCSPDSCNCASCPTHKGSNACGGKDGCTCKAGDCNCEDCPKSNSNKTKTVCNCGGDEGVCKCEKGNCACANCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFH1</accession>
    <name>A0A1Y1UFH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_656627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870872.1">
        <property type="nucleotide sequence ID" value="XM_022018846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFH1"/>
    <dbReference type="FunCoup" id="A0A1Y1UFH1">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFH1"/>
    <dbReference type="GeneID" id="33560655"/>
    <dbReference type="InParanoid" id="A0A1Y1UFH1"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="533"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="754" mass="82302" checksum="A3F55A28936D23CD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGB5</accession>
    <name>A0A1Y1UGB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_600634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871057.1">
        <property type="nucleotide sequence ID" value="XM_022013920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGB5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGB5"/>
    <dbReference type="GeneID" id="33555728"/>
    <dbReference type="InParanoid" id="A0A1Y1UGB5"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="303" mass="33547" checksum="4B16177034504512" modified="2017-08-30" version="1">MTVDKSLKIAVTGGAGHVGTGVVKLALAQGHSVVAIDIGPRGKLEPQARYEYKQVDVVDLQAYKAAVDGCNAIIHLAAALFKKVKREDGSMTINLEEEEQARVHNTNVAMSYNTLCIAAVLGIDRVVMASSINSIGMLYCKEPKYDFVPIDESHAFRPEDAYSVSKQICEVQADSYARKFPHMRIATLRFHFVAPMDLVDADKMHKHGGAWKDLWGWVSLDDTAEACLRGLTAPTSTFPLGHETFFIVAPTHAQQCDSLELLKTKYPDIKDVRKELIGNTGFFDCSKAERMLGWRASGFEWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGD2</accession>
    <name>A0A1Y1UGD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Microcystin LR degradation protein MlrC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_579375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871120.1">
        <property type="nucleotide sequence ID" value="XM_022013376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGD2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGD2"/>
    <dbReference type="GeneID" id="33555184"/>
    <dbReference type="InParanoid" id="A0A1Y1UGD2"/>
    <dbReference type="OrthoDB" id="4131805at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009197">
        <property type="entry name" value="MlrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012702">
        <property type="entry name" value="UCP012702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microcystin LR degradation protein MlrC N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Microcystin LR degradation protein MlrC C-terminal" evidence="1">
        <location>
            <begin position="298"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="55480" checksum="BF63F7CF09B606C4" modified="2017-08-30" version="1">MYRKPVIAIAGLACETSTFSPARTQASFFHPQRGDEIFDYRANPFLRAGQPLREAAEWKPALTGHALPGGIVTRKGYEELAEEIVTRLKDMGPLDGLWFDIHGAMVVEELEDAEYDLLRRIRQVVGSKTIISASMDLHGNVSQDLVHQLDLITCYRMAPHEDTIETRERAVKNLVDQLVEDRPLPYKAWLPIPILLPGEQTSTRMEPAKRIYAAVSDVEARENILDAAIWVGYAWADEVRNQAVVVVTGWNENDCVRGAEDLARPFWAAREEFEFVAPTGSLDECLDAALETRGPYMISDSGDNPTAGGAGDVTWGLTKILSRPEFKDESGPSLIYAFVPGPEAVETAVKAGVGATVTVTAGAVIDNLHAPPVTFTGKVHSIKHGDRHAEIEVVFQVGSVYAIITKLRKPYHKEHDFTELNLEPRKAGIVVVKIGYLEPELYAIAQSGTGWMLALTPGGVDQDLPRLGHKKIIRPMWPYDKVFDDDPDLTAKLIPMSNRPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGK0</accession>
    <name>A0A1Y1UGK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_626691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870726.1">
        <property type="nucleotide sequence ID" value="XM_022015922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGK0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGK0"/>
    <dbReference type="GeneID" id="33557731"/>
    <dbReference type="InParanoid" id="A0A1Y1UGK0"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="43"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="263"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="364" mass="41318" checksum="65B73205CBDA8B4F" modified="2017-08-30" version="1">MTSAIPDDFSDHVFATKHSVPLWLRVYPAPSSSSTSKGPKPWLLWIHGGAYCSGQHYQLRNWILPLFHARGYHVVANAYRFMPYVDMEDMVQDCQDAFEWCRANLADLLKDKGEIDLDRCVVGGDSAGGGLATLLVHLIPRARRPRAVINVYGVVDLVIQQDKYDHEPEPTEKWAGDVSEEALQAFYTDQDPSHAVTATTNMWNLSFLPQDTVDKGREAIYAALKDLWRVSDEEWVNDERVQRQWDIKGYNGYKKEMVTLALRITGETSTEERVDKLKTYSSTYLMDKEESYPPTVMLSGTGDNAVPVEESKSLAEKLKKKGVEVLELYCPGQDHGWDNIYTKVGDQGWDEYIEPIGKFLDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGM2</accession>
    <name>A0A1Y1UGM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Heat shock 70 kDa protein C</fullName>
            <ecNumber evidence="5">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transcriptional coregulator SSA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_625261</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871248.1">
        <property type="nucleotide sequence ID" value="XM_022015781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGM2"/>
    <dbReference type="FunCoup" id="A0A1Y1UGM2">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGM2"/>
    <dbReference type="GeneID" id="33557590"/>
    <dbReference type="InParanoid" id="A0A1Y1UGM2"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000056">
        <property type="entry name" value="Putative Hsp70 family ATPase KAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11 22" id="KW-0346">Stress response</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX37210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="679" mass="74193" checksum="66220D8AA4BFF99A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGX2</accession>
    <name>A0A1Y1UGX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871349.1">
        <property type="nucleotide sequence ID" value="XM_022015821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGX2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGX2"/>
    <dbReference type="GeneID" id="33557630"/>
    <dbReference type="InParanoid" id="A0A1Y1UGX2"/>
    <dbReference type="OrthoDB" id="2587928at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013208765" evidence="2">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="456" mass="47919" checksum="61296B4FDAEEF426" modified="2017-08-30" version="1">MTLRWTALLICLPLAVASCITNSSSTAQLQALLQEGGEGYKLELCRNQIYSLTDVLSYTAAGQEISTEKYPKDESRATLKVAGFNVTCAVKATANGLDGIALRNVQIDGNRGNEPIYTAPQANIEFGGMNSGQLIEYVRSYDPRGWSCMHIAEGPFTCRGATIQYNDIGPCGSEAFQQWADGISLSCQESLVQGNTIVDATDGGIVIFGAPDSVIRDNLIHVKTRTLLGGINMVDVLPWRPEGNFSNVLVENNHISGGFATDIGNDTMGMNNASAIIKIGIGIGPQVWWSDGRYGRNQTTGATIQGNQFSGAFAFAMAISGARDDVIRDNSFVGNVSFIGSYGPNCTVGGETPNSPVPLLEDPSLTTNLDISVPSPASSILSMAPGSGAFQTGRALGLTCFMPPASDSVSWPYGGGQVNAQPTKSGGAGLLIQPTLFGLCFTVAVAVLFTSVGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH02</accession>
    <name>A0A1Y1UH02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_625716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871371.1">
        <property type="nucleotide sequence ID" value="XM_022015830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH02"/>
    <dbReference type="GeneID" id="33557639"/>
    <dbReference type="InParanoid" id="A0A1Y1UH02"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="69" mass="7347" checksum="381480F120F2E7F4" modified="2017-08-30" version="1">MPTKGSTDGGPLVVFLSLSACYPRAGTLSSPLFSTLEFLIDRVSALLKDKHTPSNELSLTCTDMESVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH76</accession>
    <name>A0A1Y1UH76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma interferon inducible lysosomal thiol reductase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_625933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871420.1">
        <property type="nucleotide sequence ID" value="XM_022015853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH76"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH76"/>
    <dbReference type="GeneID" id="33557662"/>
    <dbReference type="InParanoid" id="A0A1Y1UH76"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012575878" description="Gamma interferon inducible lysosomal thiol reductase-domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28170" checksum="2B91E84DA9DA8316" modified="2017-08-30" version="1">MLLYGLLSSLSLVSALPSLWDTVQKPFSNALANPITHDPSRVNVTLYIMSRCSDSRICESVFEDVLRTKGIEDKINFGIQMVTQGRNESDPTGISCKHNTIECLGNAQHLCLFEHLPLQTFVAVLACENFESSFPGDIGSVAYTRHCAEASKVDWWQSGVGQCIQGKKAKKDDGKKATKKGILGKEAKELLQSNAEITWSRNITRACTIEIGSTLRTGGKRTCVVDDHIWTGCDDGHSAQDFVRVIEEEYKALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHA5</accession>
    <name>A0A1Y1UHA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_681331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871481.1">
        <property type="nucleotide sequence ID" value="XM_022019116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHA5"/>
    <dbReference type="GeneID" id="33560925"/>
    <dbReference type="InParanoid" id="A0A1Y1UHA5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="30289" checksum="A7814FE85689D463" modified="2017-08-30" version="1">MSTPHSNDSRSADGYSALEVSVPDLTAALENKRAQAAETLPSFWLTKELLESRKHPLRQKWRRTSCTIACMLEGTEDLIGQYGSNNFLEYLASVKKAIPTGYTSPDEKPVGNSAEGISTPEDPIETLTLLTHLVATGRELAEALRDAEQGDIPSDDEAEYEDEEDEEDEEDEVSKATFYDPYQDFWETCNRYASSLNAIRLHAEEVFNEAHGSAAQQSKPKRGIKESNRVSADIHESSASGLTVSGATHKRVKSVSFESTESGGKETRESSHLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHY1</accession>
    <name>A0A1Y1UHY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_641785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
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    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="589"/>
            <end position="615"/>
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            <end position="324"/>
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            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
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            <end position="445"/>
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            <end position="489"/>
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            <begin position="498"/>
            <end position="517"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="615" mass="64311" checksum="35AF6235DE3D29D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHY8</accession>
    <name>A0A1Y1UHY8_9TREE</name>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Cuniculitremaceae</taxon>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
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                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
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                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
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                <person name="Magnuson J."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="289721at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="784"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="769"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIF5</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BD324DRAFT_650375</name>
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        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
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                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018135.1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013095921" evidence="3">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="562" mass="60069" checksum="97850AC195F3A65B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIK1</accession>
    <name>A0A1Y1UIK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_406660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871880.1">
        <property type="nucleotide sequence ID" value="XM_022012699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIK1"/>
    <dbReference type="FunCoup" id="A0A1Y1UIK1">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIK1"/>
    <dbReference type="GeneID" id="33554507"/>
    <dbReference type="InParanoid" id="A0A1Y1UIK1"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="30998" checksum="827494BB824E1E8C" modified="2017-08-30" version="1">MEELSTGSESDYANSWISWFLSTKGNEYFAEVDEDYILDRFNLTGLNSEVVQDYNRALDLITDSLDEEALDEEGREVVETSARFLYGLIHARYIVTSRGLAKMLSKYRKGDFGRCPRVYCYHQPLLPVGLSDIPYQKAVKLYCPKCEDIYSPKSNRHGCIDGAYFGTTFPHMLFMVYPQMVPTKGQPVGGAGGSVAEVSRNMMAIANSNRDGGAPSAIGSVSTASSALQAERYEPRMFGFRMHEEARLARWRGAKREEQIARLENLEKIQSQQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIM6</accession>
    <name>A0A1Y1UIM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871900.1">
        <property type="nucleotide sequence ID" value="XM_022015624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIM6"/>
    <dbReference type="GeneID" id="33557433"/>
    <dbReference type="InParanoid" id="A0A1Y1UIM6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="348" mass="38114" checksum="8173A198AD68D865" modified="2017-08-30" version="1">MRISSGRLRTHAYGTYINRETRSHPLFQSPSFSQKTSNMTSATTSHGKWTVNAQQLVTSSADIEHRAWSVGQQEPQTETFDLDSGSQAKGESLGLQKKGNTIWREAGTFGMSLSGFALEDDIEQGARKAWALVRIPPVDPDNLAEEGTIDTAQLTLFFGTPKDGGRFLQDSNARISSRSLYSISLGNRNGEDPELIKFNLGIQSSLMKDGQQTVAAEYYPGLHMFQLASASASDGLSHIRAVYVRPRLGSGADNRIRVLQYAEDGSTTGSWLNVGQIHRNNPTQPVDTETEADTQPEATSRVFVDFKLEYSVSPPEDRSKDEDSPGPYNTHGGNLSDLLESLSIITAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIN4</accession>
    <name>A0A1Y1UIN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_601102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871392.1">
        <property type="nucleotide sequence ID" value="XM_022013926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIN4"/>
    <dbReference type="FunCoup" id="A0A1Y1UIN4">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIN4"/>
    <dbReference type="GeneID" id="33555734"/>
    <dbReference type="InParanoid" id="A0A1Y1UIN4"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="29"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="486" mass="53072" checksum="9AD0EFBD93D9F12E" modified="2017-08-30" version="1">MDIISFLTGKLTPYLLRRTKTPRKMGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPKYMVTVIDAPGHRDFIKNMITGTSQADCAILIIASGTGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTAKWSEARFNEIVKETSGFIKKVGYNPKTVAFVPISGWHGDNMIEATNNMPWYKGWEKEGKGGAKVTGKTLLDAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVNFAPSNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCSDSKNDPAKEAASFTAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFEELIEKIDRRNGKVLEAAPKFVKSGDAAIVKLVSQKPICVESYTEYPPLGRFAVRDMRQTVAVGVIKSVEKTDGKGGKVTKAAEKASKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIR5</accession>
    <name>A0A1Y1UIR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871927.1">
        <property type="nucleotide sequence ID" value="XM_022015640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIR5"/>
    <dbReference type="FunCoup" id="A0A1Y1UIR5">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIR5"/>
    <dbReference type="GeneID" id="33557449"/>
    <dbReference type="InParanoid" id="A0A1Y1UIR5"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62452" checksum="438977ACA81729AB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIS0</accession>
    <name>A0A1Y1UIS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">VIT family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_624455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871043.1">
        <property type="nucleotide sequence ID" value="XM_022015704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIS0"/>
    <dbReference type="FunCoup" id="A0A1Y1UIS0">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIS0"/>
    <dbReference type="GeneID" id="33557513"/>
    <dbReference type="InParanoid" id="A0A1Y1UIS0"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="325" mass="34515" checksum="ADE887613A7CB7DA" modified="2017-08-30" version="1">MAIPITRPQSDITPVWTFSEGAGTPTRAQQLENLLRSEVALEEKCGLEERKTSNVCCKELKDDDERHLISPEIVRDIVIGLSDGLTVPFALTAGLSSIGSSRLVVTAGLAELCAGAISMGLGGFLASQAELDHFHYLRRQTHNRVTRSCAGQMEREVHSILGPFGVTESVSRLVAEQLSNLESLEAVEGIEKVKASSALREQGGDAASTSLGLTAFLLKIGEGMDEVPVSRLWVSAFTIGMSYFIGGLIPLIPYMAHANTRDGLIVSAAVTGAVLFVFGAFKTYFTGAKGGWRGYLYGAMSTLIVGALGAGAAYGLVRAMDVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIT1</accession>
    <name>A0A1Y1UIT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC3/GANP/Nin1/mts3/eIF-3 p25 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_624489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871053.1">
        <property type="nucleotide sequence ID" value="XM_022015707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIT1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIT1"/>
    <dbReference type="GeneID" id="33557516"/>
    <dbReference type="InParanoid" id="A0A1Y1UIT1"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="317"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="517" mass="57991" checksum="A3FC4DB3B3DCE314" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU9</accession>
    <name>A0A1Y1UIU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871899.1">
        <property type="nucleotide sequence ID" value="XM_022018147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU9"/>
    <dbReference type="GeneID" id="33559956"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="314" mass="34865" checksum="800DFD4020D37C6A" modified="2017-08-30" version="1">MSLKEITSEKINIHPESTTAASTFGLESPVNILYAPSSFWVSISNLELSQRGRASGQTGQVLALLTLPDLVEDLVDEEGNHEASLLLLFPSGDEEWKDETRYDGAFLFDPSARVAADIFSHVQDESRKAGVEQVDFEMGVKSRLFAVTDEIDLSLSLFPNLRAFDLSEPQRDPLSDNYLYRAFLLPSTIDDEGRRRVTEITGDATSVTIRPVWHRADGSVECREENSDTEDTSPQATHESLSVKPTLQSESRHSRRGLFKLTLEPAEQPPDWKLNKSAKSSGSDEAVNRGSGQVTRKYTFGLDSARRAKISVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJJ3</accession>
    <name>A0A1Y1UJJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoplasmic reticulum Oxidoreductin 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_390935</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871661.1">
        <property type="nucleotide sequence ID" value="XM_022012660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJJ3"/>
    <dbReference type="FunCoup" id="A0A1Y1UJJ3">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJJ3"/>
    <dbReference type="GeneID" id="33554468"/>
    <dbReference type="InParanoid" id="A0A1Y1UJJ3"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801860" evidence="20">
        <location>
            <begin position="20"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="102"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="141"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX37674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="62108" checksum="5E672552D7828134" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJL2</accession>
    <name>A0A1Y1UJL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_344219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872160.1">
        <property type="nucleotide sequence ID" value="XM_022012534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJL2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJL2"/>
    <dbReference type="GeneID" id="33554342"/>
    <dbReference type="InParanoid" id="A0A1Y1UJL2"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="160" mass="17646" checksum="964D96AC66570EA3" modified="2017-08-30" version="1">MAALSTKYVSEYVSSLDLSTHARTVALFGGSNGIGEGVARKLASLGCRIIILGRDEINVDNMKREAKAMKPRGEMAEISFIKVDLLTESGMKDAVKKLKEEVGLHALDCTMLFQNGRPTGKVELTSDGILRMLIHDPYLRHEKGYAVQSLSRFVIFSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJL3</accession>
    <name>A0A1Y1UJL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_622890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871681.1">
        <property type="nucleotide sequence ID" value="XM_022015524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJL3"/>
    <dbReference type="FunCoup" id="A0A1Y1UJL3">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJL3"/>
    <dbReference type="GeneID" id="33557333"/>
    <dbReference type="InParanoid" id="A0A1Y1UJL3"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000440">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="225"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="450" mass="49833" checksum="D055221D87220A2E" modified="2017-08-30" version="1">MPPKADWEKYDRKLTDEKEEKIVALDESDIQILKTYGQGPYSLALKKIENELKEIQKRVNEKMGVQESDTGLAPANLWDVVADAERLKAHALPVARCQTIIKGIESTPDRPLNPQDGAGAGNPEGDKYVISIKQVAKFVVGLADTVSPTDIEEGMRVGVQPVNYKIMIPLPPKIDPSVTMMQVEERPPITYDDIGGCKEQIEKLKEVVELPLLDPDRFANLGIEPPKGVLLYGPPGTGKTLCARAVANRTDSTFIRVIGSELVQKYIGEGARMVRELFEMARSKKACIIFFDEVDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDARGNIKVIMATNRPDTLDPALLRPGRLDRKIEFSLPDNDGRTHILKIHGKSMSVERDIRYDLIARLCPNATGAELKSIATEAGMFAIRARRKVATERDFLDAVEKVIRQGTKFSSTALYAQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJU5</accession>
    <name>A0A1Y1UJU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_623274</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871761.1">
        <property type="nucleotide sequence ID" value="XM_022015563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJU5"/>
    <dbReference type="FunCoup" id="A0A1Y1UJU5">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJU5"/>
    <dbReference type="GeneID" id="33557372"/>
    <dbReference type="InParanoid" id="A0A1Y1UJU5"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="205"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="394"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="614"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
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            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX37774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="749" mass="82471" checksum="26A9E4FBCB3A260A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKK1</accession>
    <name>A0A1Y1UKK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_680862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022019099.1"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
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        </location>
    </feature>
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            <end position="406"/>
        </location>
    </feature>
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            <begin position="144"/>
            <end position="387"/>
        </location>
    </feature>
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            <end position="331"/>
        </location>
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            <end position="363"/>
        </location>
    </feature>
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            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="406" mass="39399" checksum="C8AE38DBDF42D7A3" modified="2017-08-30" version="1">MLFSLALAGSLALTASGMPTSAFERSTGQCGSKGCVINGISILDCTTITLGSLAAGDTCTPCPNACDSNSNQSCTVNGIGILDCANIDIGNILNQLTLGLLKRDESPADSRDRKRDSTSCAINGISILDCTTINLFDILGGGGGGGGSSGSNTCPSSSSSQLPPSSSSQAVPSSSKAPPPPPPPSSSSKAAPSSSKAPPSSSSTAAPSSSKVAPSTSKVAPVSSSSKAPPPSSSSKAPQSSSKAAPPSSSKAAPSSSKAAPSSSSKAPLSSSKAPASSSKAAPASSSRSPVPSSSSSSKAPVHSSSSSLRPSTSKEAPVSSSKAHSSSSHSTPCSTNTAMPSSSKPAPQPSSSSKKPKPSTSKAGAVSSSKAPGTCTPKPKCTPTTITVVPPAVTVTVSTTITVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKL2</accession>
    <name>A0A1Y1UKL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871993.1">
        <property type="nucleotide sequence ID" value="XM_022015663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKL2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKL2"/>
    <dbReference type="GeneID" id="33557472"/>
    <dbReference type="InParanoid" id="A0A1Y1UKL2"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="27488" checksum="48C02A2DAD1E648E" modified="2017-08-30" version="1">MTSVIPPSVPTVKWTGVDIGPWSSVLQAFHTAIKSHWKVPIEIEYIELNILEDTRNIVNGSGNTAHPSSSSSSSSSPPPHPPPSSSSSSSPLSDLLESSSASLPPHLITLLFTITELFTQSRQRTLALLRSLSACPSGTLFLVCDSASDLADFELGTQGRKWPVYMILDMIMGVKSSQGTKATSSSSSSTTTTTTTTSSSSASSSPSVSASSEPTWELIHSENSRWYRLPDGLGTHWPVKLENTRYWSRLYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKP2</accession>
    <name>A0A1Y1UKP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_370511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872545.1">
        <property type="nucleotide sequence ID" value="XM_022012608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKP2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKP2"/>
    <dbReference type="GeneID" id="33554416"/>
    <dbReference type="InParanoid" id="A0A1Y1UKP2"/>
    <dbReference type="OrthoDB" id="2596760at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="784" mass="84602" checksum="B207A717F73F4C9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL04</accession>
    <name>A0A1Y1UL04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUR7/PalI family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872584.1">
        <property type="nucleotide sequence ID" value="XM_022018077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL04"/>
    <dbReference type="GeneID" id="33559886"/>
    <dbReference type="InParanoid" id="A0A1Y1UL04"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36835" checksum="D1DF1A8C92E1D330" modified="2017-08-30" version="1">MPAKPNQRTTFGPDVAERNRVYKHSLRKTPYWITLVFLIAATALTLLNIYGTDLIHVKLRNQGPLDFETKYGLYQRCTRKSQTPNSTLLWPSHPLPDPNFKVQARIEENDAPVTDGEGEGWQCQDFPSRSECAEFGEKFCVLWSTSGYSAQLSLLPCALSLLSLLFIFLKRGERTARARARRHAWKLVSGAMLLHCNLQLLEISLVLHVFRTDDRFAAKNTHLDSSFTFGVISAIVSAVAAAMLTFTGLAARRGKSWAAGTSARKSRRHKRSKSGRVVPVPEGQTIPRDQRVPIGEVEALMPEERADERTALLEGNDGSAAGGSGQRATDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULM2</accession>
    <name>A0A1Y1ULM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_679470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872813.1">
        <property type="nucleotide sequence ID" value="XM_022019041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULM2"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULM2"/>
    <dbReference type="GeneID" id="33560850"/>
    <dbReference type="InParanoid" id="A0A1Y1ULM2"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="658" mass="72603" checksum="F6DA2B3C13267D13" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULT9</accession>
    <name>A0A1Y1ULT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">BD324DRAFT_599280</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULT9"/>
    <dbReference type="FunCoup" id="A0A1Y1ULT9">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULT9"/>
    <dbReference type="InParanoid" id="A0A1Y1ULT9"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023394688" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023394689" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="500"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="113"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="535" mass="59169" checksum="BFF14964D4FC19A4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULZ7</accession>
    <name>A0A1Y1ULZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_621136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872428.1">
        <property type="nucleotide sequence ID" value="XM_022015360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULZ7"/>
    <dbReference type="FunCoup" id="A0A1Y1ULZ7">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULZ7"/>
    <dbReference type="GeneID" id="33557169"/>
    <dbReference type="InParanoid" id="A0A1Y1ULZ7"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="304" mass="34594" checksum="82426345A77B8C23" modified="2017-08-30" version="1">MADEVDGWVAQLMQCKPLGEPEVKKLCDKAREILMEESNVQPVRCPVTVCGDIHGQFHDLSELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRDRVTILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDVFDYLPLTALIDNQIFCLHGGLSPSIDTLDHIRSIDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGFSWSQERNVVTIFSAPNYCYRCGNQAAILEVDDALKYTFLQFDPAPRAGEPLVSRRPPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMC6</accession>
    <name>A0A1Y1UMC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_649662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872207.1">
        <property type="nucleotide sequence ID" value="XM_022018032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMC6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMC6"/>
    <dbReference type="GeneID" id="33559841"/>
    <dbReference type="InParanoid" id="A0A1Y1UMC6"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="656" mass="71807" checksum="88C5D1566C8E358F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMD0</accession>
    <name>A0A1Y1UMD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="6">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_376444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872599.1">
        <property type="nucleotide sequence ID" value="XM_022012623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMD0"/>
    <dbReference type="FunCoup" id="A0A1Y1UMD0">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMD0"/>
    <dbReference type="GeneID" id="33554431"/>
    <dbReference type="InParanoid" id="A0A1Y1UMD0"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="8">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="7">
        <location>
            <begin position="149"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="9">
        <location>
            <begin position="388"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="568" mass="64263" checksum="82447FC7F76C6A21" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMZ8</accession>
    <name>A0A1Y1UMZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_362583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872427.1">
        <property type="nucleotide sequence ID" value="XM_022012584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMZ8"/>
    <dbReference type="GeneID" id="33554392"/>
    <dbReference type="InParanoid" id="A0A1Y1UMZ8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="89" mass="9773" checksum="9E4ED4A69BAC0263" modified="2017-08-30" version="1">MQSSSLLHIPHSLIAGWLLMKHSVMVNGTITLSIFPGTLPDDTLTKFKSYPTELSFGQCGTGTRSKKLTSWTGTASRQEDSMRTMLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNN2</accession>
    <name>A0A1Y1UNN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Velvet factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_655361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872939.1">
        <property type="nucleotide sequence ID" value="XM_022018813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNN2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNN2"/>
    <dbReference type="GeneID" id="33560622"/>
    <dbReference type="InParanoid" id="A0A1Y1UNN2"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF15">
        <property type="entry name" value="VELVET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="5">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="197" mass="21463" checksum="D0D896D9CE0C7E4E" modified="2017-08-30" version="1">MNLSSVDHGALGRTYRITPIQQPERSAAFQGAYLSRLPLSPPLIIQLDVWNEAGELIIPYEELPFLVCSISLETPSGSSASHIQDPNSGEVVSLLYGTLVTTPTEMLDQSGAMGVYFAFPDVSVRVEGNFRLSVNLLRITGPALIEGMNSGNALHTCCTNSFDIVPSRDYVAPPVTDLTRHFDAQGLIRFGLPRAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPG6</accession>
    <name>A0A1Y1UPG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_607700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873267.1">
        <property type="nucleotide sequence ID" value="XM_022014077.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPG6"/>
    <dbReference type="GeneID" id="33555885"/>
    <dbReference type="InParanoid" id="A0A1Y1UPG6"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1743"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2037"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="973"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1239"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1281"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1313"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1387"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1495"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1530"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1564"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2066"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2082"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2109"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1772"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2142" mass="227987" checksum="11C0F9B5ABED23A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPM3</accession>
    <name>A0A1Y1UPM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_607507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872948.1">
        <property type="nucleotide sequence ID" value="XM_022014074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPM3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPM3"/>
    <dbReference type="GeneID" id="33555882"/>
    <dbReference type="InParanoid" id="A0A1Y1UPM3"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012869705" evidence="2">
        <location>
            <begin position="24"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="130"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="457"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="620" mass="67878" checksum="733213EEE72558E7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPM7</accession>
    <name>A0A1Y1UPM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative adaptor complex subunit medium chain 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_615931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873795.1">
        <property type="nucleotide sequence ID" value="XM_022014771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPM7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPM7"/>
    <dbReference type="GeneID" id="33556579"/>
    <dbReference type="InParanoid" id="A0A1Y1UPM7"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="190"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="459" mass="50637" checksum="3947BD16BA1942F7" modified="2017-08-30" version="1">MMTRIDGLIILDPIGKPLITSHFSLHPPTYPSIHIDTFNHLRKQSIARSKVLDSVIGVNAIDNDGRELGTGLCWLEREGLKFLVPISEELNPLFAFSFLSSFLATLEDYLGDITENSIKENFEVVYMLIEEMLDEGHPMTTETAMLKDIVLPPTLVRKILNVAGVSGIQSPTSPFTAPIPWRRQNIRHANNEIYFDIEESMEAIVDRRGSVLSSSVWGRVNAKSRLSGNPDLLLTFSNPKLISNCSFHPCIRYSKWEKNGVLSFIPPDGRFKLLEFQVPPMRVQLPLQLVPKMSIEENGGGQFSLTLTSRTNHRPIQDIVVSIFLGYGTNGVSATATGDKRAGGGDAHGPGAPVLGTKSEVGDGYVGGGTWEFDPHTQVMKWTISSLVSTERPPTLTGSFTSSETHSTPSPAFDIAFTIPNHSYSGLKVDQLKVSGDVNYKPFKGIRQIARAGKMEVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPQ7</accession>
    <name>A0A1Y1UPQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_648625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873796.1">
        <property type="nucleotide sequence ID" value="XM_022017864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPQ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPQ7"/>
    <dbReference type="GeneID" id="33559673"/>
    <dbReference type="InParanoid" id="A0A1Y1UPQ7"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="439" mass="46657" checksum="C7C3F1F4A50B8BF7" modified="2017-08-30" version="1">MSHVYSFIAPSSAPATLFDVSISSDPSASSSSSSSSLTSIAVNHASHAPIGSVKRICKTSDGSIVLADDAYRLSVLSARPEEVDWEPEVITQHEVSHRKGDLWSGLIPVSSGFISSLSSGKITYNGLDSALAGESSNSHIVDGHVLALASPRPSSNTFALAGKEIDVSIRDVERTFASSSRSQNGEGGSSKKRKTELVEGEIWRAKNMPNNSLQLRPPVHHLCLAYLPLPSGSESGDSTHLVSGTKAGTLRRYDTRQRKPVSEHKLAREGGIGAIAPVNEHEVFFADRGNFVGCADLRTGKLMYSYPGLTSSAHHLVYLNGSPVHPTSDDNSYDEVGHTLREGLLASISPDATLRLLSTVPPREPASKGNPQGGKAKVVGVAGGVGLGSFIYTGFKYRPVVQEEGNEESERAGGSEEGDEDVWNDMDTADSDEDEDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPS3</accession>
    <name>A0A1Y1UPS3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_251378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873816.1">
        <property type="nucleotide sequence ID" value="XM_022012288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPS3"/>
    <dbReference type="GeneID" id="33554096"/>
    <dbReference type="InParanoid" id="A0A1Y1UPS3"/>
    <dbReference type="OrthoDB" id="2587714at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="424" mass="47930" checksum="9CC96F25D5C65866" modified="2017-08-30" version="1">MQEGRNSPNKRRRTSDRLGEATIAVKRRKCAVAPTSQNRVHLTHDALLYFRDHLQEHGLKGVAAQLLSANQSFFNLFLPVLDYERLVLHSQNADTLCRVFHRVCPSGDPPEGLDSCTSSHSKCRLLKTCRYLTIEDPPALEALIKAHKPCFDGAKSDGRLLAQTHHKLFPNVTHLSVKGPLAWKLALDYYSDSSHDQAWRKIRSLIKIINPLHLCIYFQRPVFPGYLVMDPPIDPEAHLDAATPEEVDRWIAENKTARFGISEIVRVLDQSWDLESITCHNVTEEDFPTVYCPSHRVIFRPLYRAIGDLRTLRCIETRVSQMTEAVRQLGDDDYSFEFVGLENIGGGSAKRLYMAENQRLTDPSKDSCAEDELLNKLVLNPTHPNTLIAQVWGRLSLKERAAAQPHVKFSSVAEACPCRCCGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPS4</accession>
    <name>A0A1Y1UPS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_616097</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873843.1">
        <property type="nucleotide sequence ID" value="XM_022014792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPS4"/>
    <dbReference type="FunCoup" id="A0A1Y1UPS4">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPS4"/>
    <dbReference type="GeneID" id="33556600"/>
    <dbReference type="InParanoid" id="A0A1Y1UPS4"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX40058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="25827" checksum="00CC0ED015DF748D" modified="2017-08-30" version="1">MVRSTTIFRVSDALPLAASVDDENTEKALTEYKQQSKLVFRRLNANSEPACSIESGQYTLHYLIVDKVIYMCICDSSYPRKLAFSYLDELSKEFQNSYGDKIDSVTRPYAFMGFDTFISKTTRLYRDSRTLTQGGGPTAGPSSQLDQLNENLKDVTRIMTKNMEDLLWRGDSLDRMSHLSTSLRAESVKYRKAARNINLQALLRKWAPVGGIGFFFILFAWWRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPZ7</accession>
    <name>A0A1Y1UPZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_641367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873078.1">
        <property type="nucleotide sequence ID" value="XM_022017419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPZ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPZ7"/>
    <dbReference type="GeneID" id="33559228"/>
    <dbReference type="InParanoid" id="A0A1Y1UPZ7"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56687" checksum="6C5AAF7222B5E493" modified="2017-08-30" version="1">MTEKMSEDGSLSSSLSQSSADSIILSPMSIESESRLLKSPSEILHRVLCTSGADDPFAIAQAAKTCSQLRSFIYDNPDSALWRDIYLQRYDDPKRAGAFCSPRPPPNWRKQVQDRELVSRMLRTWDKDDLVSHLDLIASTLLDLYLDLPATTAPSSSDEDPLETDESPNGILLSSLLQSEGFRDLYFEHSTTETKPLLRPLRAQPGNPNRQVQRRAVNADLMRLHVLLSPDFSDEEVHRQQRGWLREMVYGASNYSVENDWGPFNPDGTVDWTLVDAVGSVMMGNAKDVLFMGEDTWRQALPPMSYGIEPTRGWGFNDLSNVEDWAGVEGVWCGSYAFLDLADLSYTDWITLNEPGLIQLRRSLNTLDLTRYHEAVGDLMRLELVIDREGYKPEPMPRIETNLPTSSLLPPIYFHGSSVQQSSAITFASNSSASFVRGVVQLTADDPPQVRWTLVIRYGGEDRWRLECVQVGGRGSKRGFFGIWTDALKEEHSPNGPVWYWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ27</accession>
    <name>A0A1Y1UQ27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_616513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873926.1">
        <property type="nucleotide sequence ID" value="XM_022014834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ27"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ27"/>
    <dbReference type="GeneID" id="33556642"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ27"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="354" mass="39347" checksum="77CA12F6C2578084" modified="2017-08-30" version="1">MRRIPQQIPELVGRLIKSEHISKQPTWYAAAMANPPPTLPPYESRPRPPLHINDGRASGSNTTVEGRPIPSQGLKFNALQIERLSKKQPKYGARIVTKPRKIVYPEDRLRLQFFKDFPFEAMRPVSLVEMRTVEMDKGVTGTAWKTLRQRGAYPTVENVVAFVLNLIESHGYLYSAAYTEATKQFVELRAMHEMSTLAAELEARHYGAEFNIDPFTRAHMKENKALDAHLSATQRGERVVSTRIKWKNPRKTRWGTELHPDAVTQGPFTGGQAYVEAWRRRAIPKAASSKAAQSPSSEGPSGQKPLRVAAADEAHTGEAGDAATGETVDIQDSVLQTIPTPNSPTPQNAQASDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ84</accession>
    <name>A0A1Y1UQ84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873401.1">
        <property type="nucleotide sequence ID" value="XM_022017810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ84"/>
    <dbReference type="GeneID" id="33559619"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ84"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012847275" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45265" checksum="62830F06E04CB230" modified="2017-08-30" version="1">MWSALLLLLFTNPAVGTSVQPRAIIDPTIKTATLYGVIAQYEPNYLDRDSCGTTAWGDRVLYVCRDTEIYVDRENTTKGTAAFFSSSASYINKNADGSLPFEPYNSSAYGDYGYEMGFKYRLPTYGNNHNMSFYPLQADEDPQDNGGNTTAGTRFVIWPDSPPLVSPQNTSSSSSTCGDGKIRAYTWIKKAEITDHLSVVIPYPATSLYRLDYDPAVQGHGDTLPEVTIVQEEFFKENEWNYGTYGSVSGNGYSYLYGQPLAAPNVSLARVPQGSEENVSDYEYFVGGQWTSTMPALNDSASWLPETFGAQGSFYYSEVWQCYVWIGQPQNNIAFDVLISTAPAPEGPWTGPKLIYTENDHLTGFHYTIQANPALLSSPTENAMWVSYTQAISGYGYNTILYKFDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQF0</accession>
    <name>A0A1Y1UQF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_640943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873572.1">
        <property type="nucleotide sequence ID" value="XM_022017384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQF0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQF0"/>
    <dbReference type="GeneID" id="33559193"/>
    <dbReference type="InParanoid" id="A0A1Y1UQF0"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="743" mass="78616" checksum="08461F2980C18048" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQH8</accession>
    <name>A0A1Y1UQH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator of RNA polII, SAGA, subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_648818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874007.1">
        <property type="nucleotide sequence ID" value="XM_022017893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQH8"/>
    <dbReference type="FunCoup" id="A0A1Y1UQH8">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQH8"/>
    <dbReference type="GeneID" id="33559702"/>
    <dbReference type="InParanoid" id="A0A1Y1UQH8"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="419" mass="45845" checksum="F4E3B6C9E7554022" modified="2017-08-30" version="1">MSDSGPESRDEASNAVVESGHHVSPRQNGMMTHQPEAGPSRPPPPPLPPMVEKLFATDIQLIKQELHDALGEAGLAYWKTLNGYLLGQIGKSELEVMVRGWLKGSKVQLHNQFMMALLYHAGIPHAPSSGGKKRKRVGPEDPDYDVNEYIIEPKARVQQWMQGIGGRERARIRRAVIGRQGQDEDTAGEADPSSNKNWGIQAGNTMPPLAVSAKQLPASHQLSHRLSQLAKAYDLNLAPDALSAIGEFMAVELDAHLSDILHAYVHLAARDRIGSDTLHVPPGLNPDLDLDVKVEDGGMTKPDLDRLRDLFTLNPGLHPSTSPALYKLASSLSQAEAEYNSSPLKLERKPSLTPEIDVTPQVNGDRAGPMMKKLVNDGLVKVDNVKKGEDGEVGGKKDKKHNLHWRYEDPALILKDVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQL6</accession>
    <name>A0A1Y1UQL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative beta-glucan synthesis-associated protein SKN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_271651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874064.1">
        <property type="nucleotide sequence ID" value="XM_022012342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQL6"/>
    <dbReference type="FunCoup" id="A0A1Y1UQL6">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQL6"/>
    <dbReference type="GeneID" id="33554150"/>
    <dbReference type="InParanoid" id="A0A1Y1UQL6"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="164"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="580" mass="62763" checksum="214C5BB24A39232D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQR3</accession>
    <name>A0A1Y1UQR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_614981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873571.1">
        <property type="nucleotide sequence ID" value="XM_022014669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQR3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQR3"/>
    <dbReference type="GeneID" id="33556477"/>
    <dbReference type="InParanoid" id="A0A1Y1UQR3"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="138" mass="15110" checksum="666B260408310CE3" modified="2017-08-30" version="1">MSMFRIASRRLALSASFPKRQFASSSFVAASRHGNDPEVLGREKARNLKGTQDSSTPFKEGAPGWNEHLASDSEAAVKADHHTKHEKPTKELQDATVAQTHAHHDKGGHKHGVEHHDAKHQKAQTGSEEAVKADRGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQS4</accession>
    <name>A0A1Y1UQS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873712.1">
        <property type="nucleotide sequence ID" value="XM_022014739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQS4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQS4"/>
    <dbReference type="GeneID" id="33556547"/>
    <dbReference type="InParanoid" id="A0A1Y1UQS4"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="398" mass="44915" checksum="05DB6E58FD54EE73" modified="2017-08-30" version="1">MSIGTPALYPLNIPSAPPSSSFSDNMSELESVSIESATHRRPFPSSSLPSTPLLRSTPALDQQPSPTDTILQTPEFKATSPGISQHAHLKSFASMPSPLMMDKLSIPLLPHRSIKRVADQSPPRTPKGHPLEASRRVYTISNPYTTTAARILRVPRRLRPLALFSFCAFVFCVVYLNHVMSTTPAVAPVVQQQSYVFMEEARIQRVPTRVRPHLAFQNTYEELAALISFVTSTTANSLPDLNPERPIDPSTVLDFDPSHENARDDLDLLVEHVNTVYPLVLFGKMRDPWHREIRKILHSYRIYPEPLIVDVDQRRDHHVFVPLLQRLLDTPDLPQVLIRGQVIGSYHEILAMKDSETLVPTLEGYGLSVRDLKKRKGVRERERVENERILGPAPIEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URC6</accession>
    <name>A0A1Y1URC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_607169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873829.1">
        <property type="nucleotide sequence ID" value="XM_022014054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URC6"/>
    <dbReference type="STRING" id="4999.A0A1Y1URC6"/>
    <dbReference type="GeneID" id="33555862"/>
    <dbReference type="InParanoid" id="A0A1Y1URC6"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="560"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="765" mass="82268" checksum="C19ECE6E8A43C389" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URT9</accession>
    <name>A0A1Y1URT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_574524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874440.1">
        <property type="nucleotide sequence ID" value="XM_022013065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URT9"/>
    <dbReference type="FunCoup" id="A0A1Y1URT9">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URT9"/>
    <dbReference type="GeneID" id="33554873"/>
    <dbReference type="InParanoid" id="A0A1Y1URT9"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="316"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="445" mass="50173" checksum="FB1820416CCC671C" modified="2017-08-30" version="1">MSRFKISAALWDRIHHFASFPQTGVSLQQMILFGQHPSQGTLLKASQFLSEELPIRLAHRVVELESLPYGISETPSITKVKEWYAQSFEELVTFPRPKLPPEIQEMLRVQPKDDSQFPSATLNPSLDPLMHEGPVGSNLISERGGYIGQMGLNGSGSSGPRLRIPIERRYFSPPSPDITYPPEVHEYNDQFTDLLQNIKRRHDPTVTTVAQGVLEWKRNQKAGRIDQSIQEWLDRFYMSRIGIRFLIGQHVALNTLQPHPDYVGIICTKSNVHDICHEAIENARFVCEDHYALFKGPPIQLLCPKDLTFPYVPGHLSHICFELLKNSLRAVVERYGVANEDEFPPIKVVVVEGSEDITIKISDEGGGIPRSAIPLIWTYLYTTMSDEGLEANIESSDFKAPMAGFGYGLPLSRLYARFFGGDLRLISMDGYGTDVYISLNKLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URY9</accession>
    <name>A0A1Y1URY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874482.1">
        <property type="nucleotide sequence ID" value="XM_022017702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URY9"/>
    <dbReference type="GeneID" id="33559511"/>
    <dbReference type="InParanoid" id="A0A1Y1URY9"/>
    <dbReference type="OrthoDB" id="2553298at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="12"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="198" mass="21439" checksum="4D492299BBE998EC" modified="2017-08-30" version="1">MPKELTRNQVSNGLTYVANTPSFLKNFGKPPPSPPPAERFDHSESSGRPGREPLPERPRDGKWAKGSDDEKDDTNNPDSDDEWGEIYGGGGEDGPQVVVLKEGRHLSADEVKRERRRAAGKPSKSPSPEAAALPAPNEKETAKPKTQIIKTASTSSKRKLVGKEESKPDALTAAVAKPKKKKKMDKGLLSFDEADGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US30</accession>
    <name>A0A1Y1US30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_678261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874520.1">
        <property type="nucleotide sequence ID" value="XM_022018982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US30"/>
    <dbReference type="GeneID" id="33560791"/>
    <dbReference type="InParanoid" id="A0A1Y1US30"/>
    <dbReference type="OrthoDB" id="2565352at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="879" mass="95934" checksum="6836188A149BEE8F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US43</accession>
    <name>A0A1Y1US43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_612140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874478.1">
        <property type="nucleotide sequence ID" value="XM_022014359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US43"/>
    <dbReference type="STRING" id="4999.A0A1Y1US43"/>
    <dbReference type="GeneID" id="33556167"/>
    <dbReference type="InParanoid" id="A0A1Y1US43"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF122">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="42"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="631" mass="69929" checksum="2FB7A8AEDE934038" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI9</accession>
    <name>A0A1Y1USI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation efflux family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_575009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874286.1">
        <property type="nucleotide sequence ID" value="XM_022013098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI9"/>
    <dbReference type="STRING" id="4999.A0A1Y1USI9"/>
    <dbReference type="GeneID" id="33554906"/>
    <dbReference type="InParanoid" id="A0A1Y1USI9"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="76"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="279"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="40368" checksum="4AA51B8E9D18A57F" modified="2017-08-30" version="1">MCSGSESYWIFILLASFPTITLRRKNKKRIGKKLAAFYSAQNDHIQDMLKPLSTLSAEGEQSAEDMALKVKIAVNASLIANVCLAALQLYAAISSGSLALFASCIDAVDPVANLILYMAHRASDRAEEKKWPVRGSRFETSECKAVYAFIMAAVNLILIVESIQNLVTYDGSETKKFHVPSIIAVGVAFVTKLFLFLYCLAIRKASSQVQVLWEDHRNDLLTNGFGILTSAGGSKLAWWLDPMGAMMIAVTIIIVWSRTIHEQFTYLAGIVAPVEYQNLAMTFSPDIRQVDTCRVYHSGPNYFVELDIVLPPEMPLWRAHDIAQDLQDQVEALPDVDRCFVHVDHEVSHKPVSGIEGMYGIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USK6</accession>
    <name>A0A1Y1USK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="6" type="ORF">BD324DRAFT_611572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USK6"/>
    <dbReference type="STRING" id="4999.A0A1Y1USK6"/>
    <dbReference type="InParanoid" id="A0A1Y1USK6"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="427" mass="46289" checksum="313859AF01367076" modified="2017-08-30" version="1">MADRQRGVQIHRPIIYGSHARLLTDAERELSTQGHTHRWTVFLTSAASPPPKAGVEDDFLPGGADDLSYLIKKVTFKLHETYPNPSRVLDKPPYVVSETGWGEFVIQIRIQFVNEAAEKPMIFQHGLKLHHWGKPIEDMTTTEGSVSVATGVINGSSTPSAAGGVVTGSVPPLSGAEKKDGEADSEVKAETSTPRPDIVMGEDEDTKADPETSAEASGSQPPPSAAETHHTRAHTHAQVIAEQRVSAAAKWPVLAWQYDELVFSDPPLAFYNLLNEHPPTKLPAKNRRPRDQREQFESKKKAKTKNAIASSSRQATVEPVSTPATQAVGTPAADASGANGAAAPARTERQQSSAATPAPTSAIVGIPGEFGSADVPLEFTTEMEKAEWNKLHTTRTKIIDEMDRWRSKLIEHEKELAKLKEEMTSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USN5</accession>
    <name>A0A1Y1USN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_654638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874700.1">
        <property type="nucleotide sequence ID" value="XM_022018801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USN5"/>
    <dbReference type="STRING" id="4999.A0A1Y1USN5"/>
    <dbReference type="GeneID" id="33560610"/>
    <dbReference type="InParanoid" id="A0A1Y1USN5"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="611"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1270" mass="134060" checksum="620BCCACC014FFD5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USP6</accession>
    <name>A0A1Y1USP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_640689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874661.1">
        <property type="nucleotide sequence ID" value="XM_022017361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USP6"/>
    <dbReference type="FunCoup" id="A0A1Y1USP6">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USP6"/>
    <dbReference type="GeneID" id="33559170"/>
    <dbReference type="InParanoid" id="A0A1Y1USP6"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="326"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="444" mass="49740" checksum="62AD269F4FF0CA6B" modified="2017-08-30" version="1">MTARIEPIPPPFFSPYLDDQCNKINSKPVPWEGYQRAKLLSADELNLLKSLAKIPTAQRPTVYASSGAQYARLYIDLLRKLQRVDTVQAVLVSINDMLVSDPSSTIPLFHSLATKENPDDPYAPIVKCLAMEEEFVILTSLKILGVLIATDSREFPYNLTGTLLASLQGLLNGSRIPLWEVAAQVLSAVLGTKQFRLAVWEEEQCISGLVKMLKTTSNPQNQYWAVSCLWQLSFERIAAEGMNKRYDIVALLTGVAKAAVKEKVLRVIISTFRNLLTIAPSQSLPSFFTSKVLQFVITLQDRKWSDEDIPEDLSYLKSELSARLENLTTYDELISELDSGHLVWGPVHESEDFWKENAMRIGQESGGKAVKRLVELLKNSREPVVLAVAAHDLGFYIRYGGDKAKQIVTDLGGKTRVMELMTSQDPDTRYQALMCTQLLMSQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USQ0</accession>
    <name>A0A1Y1USQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_34684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874717.1">
        <property type="nucleotide sequence ID" value="XM_022012543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USQ0"/>
    <dbReference type="GeneID" id="33554351"/>
    <dbReference type="InParanoid" id="A0A1Y1USQ0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="28247" checksum="3371A20CA450CD30" modified="2017-08-30" version="1">MLLRVVRPEPTSTAKPTTKSEGKRFRQEPILGDYEWVNVSDAGTIRPEGDFKGSSHGRGTKHYIRSDPSDCSENPLGDMPGSRRYRLDSSSDSGEFPVRLWEFHQLTGIDEQDRRPSRSDASCPGTRAISDSLRSLNLENTQRVVKSGMSVLRLVNYGGSHSKLDDAVGQFQASLNTAGLVLAEKAEWDEMEGTRSADRSRKDALTKSQKALKVAQLEIDRLTSMTEHYRNHADRLWSETCGVSYPPRTTASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT10</accession>
    <name>A0A1Y1UT10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Capsular associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874838.1">
        <property type="nucleotide sequence ID" value="XM_022014499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT10"/>
    <dbReference type="GeneID" id="33556307"/>
    <dbReference type="InParanoid" id="A0A1Y1UT10"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="73254" checksum="092608D36C2B8A32" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTX4</accession>
    <name>A0A1Y1UTX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_575252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874555.1">
        <property type="nucleotide sequence ID" value="XM_022013116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTX4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTX4"/>
    <dbReference type="GeneID" id="33554924"/>
    <dbReference type="InParanoid" id="A0A1Y1UTX4"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="489" mass="53766" checksum="2DFD6E9A4EE0908D" modified="2017-08-30" version="1">MIQPDPSFSIHLALPRRSWHLPLDDRLRAFSKRFCPTWLLYPFLALWCMAFILLIRQQYYVGNIGVISCDAAVWADWPPDTCGIDGFACLDQLEEGTYRCLGGCQGVPLGNPRWVGGVSVDGIPLVIGGNDSIYRADSWVCPSAIHAGLVSPTLGGVITVKPLPFIWGHSDFTSSKAHGIQSVGFEPKYPGAYRLVSAPLNGNLDLHPIISTVNALCLAIVTLFLRPSPPILFSILVVLGWFQLTLISDPASFPPDWGWVAGGIPLVLLTAYWAYRVAFQRTLTAFRDLPLDTTIWQGAGYWIGLESSTIFAKLPISRLGYGGLSADGVIALVLILIVVLIVVLIQAWQMRRYGLLQYYLIRYLPLAPILLILAFIPGYTLRIHHYLYCLAAIPVLSLPNRVSLFGQAFILGLFLDGVGRWGWASILQQTTSLIGDANTGTYVPFPLNTSTITDISWEPITQNLTEMGYTGVAVMVDDILRAIVNSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU56</accession>
    <name>A0A1Y1UU56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_648057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874846.1">
        <property type="nucleotide sequence ID" value="XM_022017771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU56"/>
    <dbReference type="GeneID" id="33559580"/>
    <dbReference type="InParanoid" id="A0A1Y1UU56"/>
    <dbReference type="OrthoDB" id="2561307at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15648" checksum="C656E90D34F723F3" modified="2017-08-30" version="1">MPLDVEGVRELFAPLTKADWPGFMTRVRDDVSWTVGNGVIHSFPVAGTHNKEAFLKAFKPLSECFDDPIPMNVTNIIPYPDGSGAAVELTVKVKAKDGSPFDNFYCWVTEFDDASPPKVKTVRAYLDTALVKSVMEKNGHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUI1</accession>
    <name>A0A1Y1UUI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_613773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874913.1">
        <property type="nucleotide sequence ID" value="XM_022014534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUI1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUI1"/>
    <dbReference type="GeneID" id="33556342"/>
    <dbReference type="InParanoid" id="A0A1Y1UUI1"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX41234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="334" mass="37644" checksum="E61E6E9F56A5E5A2" modified="2017-08-30" version="1">MIGSRRGPAISPLADAPLLSNGQPKPSPNTPYFPPSDTSTYRDLLLFEERLKMNAEMLRRRRRRYAAFLWTFVTALLYLAHWLIFLPPATMLSLRALQATVAVVFITLALFFASGMYEEKIRYAHSYINHSNRGLRQLNMHLNMRRQRPPLPAFLPEFLRPAPVIKPPSHLPSKPFNGSTIASRRPSHNATVMAQIPPSSNPRGELIFSSRVDKGFREGYERYRAAFERRREEKAREEARRNRKLWFRRKALNETPINRIMTPTPPASRRNTPPPGVNGATSAASSGTVPGVRRGRSPSPGPSSLGKVEANGQQNDGASSRRSRSNSEGNKYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5S0</accession>
    <name>A0A1Y1U5S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative proteasome subunit alpha type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_639888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867719.1">
        <property type="nucleotide sequence ID" value="XM_022017296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5S0"/>
    <dbReference type="FunCoup" id="A0A1Y1U5S0">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5S0"/>
    <dbReference type="GeneID" id="33559105"/>
    <dbReference type="InParanoid" id="A0A1Y1U5S0"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="263"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="34310" checksum="AA0B3FE7DDB8F979" modified="2017-08-30" version="1">MFRNSYDSDNVTFSPQGKLHQIDYALEAVKQGSAAIGLRSKTHAVLLTLKRSTGELATYQKKLIRIDDHVGVAIAGLMSDARVLSNFMRQQAMQSRMLYGRPIPVGRAVQGISGRAQNNTQQYGRRPYGVGFLVIGRDETGPHLFEFSPAGTTFEYYAHSIGARSQSAKTYLEKNFESFENASLPELINHGLSALHDTLQQDKFLTIQNTSIAIIGPSSDEVEDISISGAAKRGNFRVWENEHVDRLLRAWRRSRGEPEDGPQEAAPAPEATTEGGAEATDSTAATGGDSSSTEAASAPASGDAPSSGTGGSGDDVEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6T1</accession>
    <name>A0A1Y1U6T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endothelin-converting enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_584453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868052.1">
        <property type="nucleotide sequence ID" value="XM_022013683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6T1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6T1"/>
    <dbReference type="GeneID" id="33555491"/>
    <dbReference type="InParanoid" id="A0A1Y1U6T1"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="297"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="700"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="100911" checksum="D6449F1F16FB6DC2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Y6</accession>
    <name>A0A1Y1U6Y6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868090.1">
        <property type="nucleotide sequence ID" value="XM_022017133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Y6"/>
    <dbReference type="FunCoup" id="A0A1Y1U6Y6">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6Y6"/>
    <dbReference type="GeneID" id="33558942"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Y6"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="52"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="163" mass="18217" checksum="FE9BA6D7F87A0EA4" modified="2017-08-30" version="1">MLYRLLRPQKSSLSQCEAIIRTVHSSMSFSLPYKYITADELAKILKAKPASDVKDIAVVDVRDDDFAGGNIVSAVNVPSSTFHDSVGGLVKRLEKCPSVVFHCALSQQRGPKAARIYAETREASLSSPPTQQIYVLRDGFTGFQSKFRNDPELVEKFNKYYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Z0</accession>
    <name>A0A1Y1U6Z0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868061.1">
        <property type="nucleotide sequence ID" value="XM_022018712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Z0"/>
    <dbReference type="GeneID" id="33560521"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Z0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="365" mass="41072" checksum="2C771E8C35878A10" modified="2017-08-30" version="1">MLFLEFLPTITSVRTAKSQRRSLEAVVRRRLKDIATEWTESLQDSVQAINDESEDYQASIASLKLSFNAWMTYPAVRQLADYCTDHAGTWDGKSDIQITGQPSEEIEASECHAYTLTMSVTSRRGDTEHVLHLPVTMEDQPDSGWRFKIDKDKVKFRCINHMTNMSQFHGSPQLPPQEFSTLKSRVESLLRSAADTIETSTEQPLIAEGGLDAESIRSLIWSLGSWTRSRDIPTRFCLEYQSHGGTLIGNPSIKLSWVWDQPRESPGSSLLRFGLGVESDYNEFLRVLSVPVNGMQDRAGWEFRIPHKDDFDQDRSDQDEEGKRVGWVYFPRGTSFTQAMEAFRTGNSSGNGGLGGRSEGGTNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U786</accession>
    <name>A0A1Y1U786_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868177.1">
        <property type="nucleotide sequence ID" value="XM_022013669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U786"/>
    <dbReference type="STRING" id="4999.A0A1Y1U786"/>
    <dbReference type="GeneID" id="33555477"/>
    <dbReference type="InParanoid" id="A0A1Y1U786"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="558" mass="60622" checksum="BA2013359EA376D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U813</accession>
    <name>A0A1Y1U813_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_658250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867994.1">
        <property type="nucleotide sequence ID" value="XM_022018879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U813"/>
    <dbReference type="GeneID" id="33560688"/>
    <dbReference type="InParanoid" id="A0A1Y1U813"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="371" mass="41294" checksum="5F56719165E6EBD6" modified="2017-08-30" version="1">MRGRDPDQLPTSVTHQVPIAVEMVQLGRPENPEDRHATAARAYRQGYLDASSAYLSGPSAHSNTPSFLRDLAREYPYTTIATVGALGSFTLLTSGYLASKVFRRAVGVTRTGTSEAIWVTRVDDLERRLVTQVQSSSRDRAREMDTVRREILSSLSAHATVGTMCAIEDKLADVVKQIERSSSDHQKGLHKLLSQLEANNRDRRIELNGLRTELMGELQRGSQDDHGEQLDKIFDQMVASNRDRRTELHGFRSEIMGELQLTRSTSPGPQVTLSAQQAADFEGFRTEIMDMLQRMEHNMKKMTPTAKVHPPQPGVAQMDEVELARVLKETTEGIFGSKKSASSNDDGDRGRLSFSHYRSILTGHGRGSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8K0</accession>
    <name>A0A1Y1U8K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein SEC72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_583396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868634.1">
        <property type="nucleotide sequence ID" value="XM_022013621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8K0"/>
    <dbReference type="FunCoup" id="A0A1Y1U8K0">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8K0"/>
    <dbReference type="GeneID" id="33555429"/>
    <dbReference type="InParanoid" id="A0A1Y1U8K0"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24884" checksum="0341C5C40986F847" modified="2017-08-30" version="1">MPPGMGPPMQIPVNPAMQTLLDSLPHHPVPIFLANVQIPNSQPPQINTIAVCPEHKQSICEACGVDFNGLNYMHQFLRGAPDEAIPPPPNVQPPPQRAEMIKNMKEQGNTAFKEGKFPIAIQHYSKSADMALSRAPWELAAVSREETAIALCNRSAAFAIAGAWQNALADAEAVVALKRPWGKGHFRKARALLGLERLEDARQAIIDGLQFEPNDDVSPHFLHSSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U962</accession>
    <name>A0A1Y1U962_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_638975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867945.1">
        <property type="nucleotide sequence ID" value="XM_022017180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U962"/>
    <dbReference type="STRING" id="4999.A0A1Y1U962"/>
    <dbReference type="GeneID" id="33558989"/>
    <dbReference type="InParanoid" id="A0A1Y1U962"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="365" mass="40954" checksum="78F32D1A47FBE4A0" modified="2017-08-30" version="1">MYWYLSFLRPPPKSVSVTEDCIQITPQIANDLRTELRYVPTDIGYVWQRVQPASSQDDALEHLTTWTPPQSTYKTLSVPLPTDVKPGQSWRLGLETMNPDGPNVPSLASFACPNPPIVPVWSAPIQFIQGAAPAVKQDRIQREWMIAEDTLRVIEQTSFDLDKKIWDSGLALSAWLWYHLIDHADRLPNDDGEKLLSRLRDPEDRTILELGGGTGLVSHVLRQAFDKLGCPIVTTDLDTAIPLMEENIALNRTRGQGPIKAQILNWDEPLPSLQDPWPSIIIAADVTYNTASFPSLLRTLCSLMKPTSAVEAPMLLLAYKERDPGERELWEMLRKEGIRMTNVDVIQGAEEEGVVELWVGSVESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U973</accession>
    <name>A0A1Y1U973_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_638213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868344.1">
        <property type="nucleotide sequence ID" value="XM_022017089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U973"/>
    <dbReference type="GeneID" id="33558898"/>
    <dbReference type="InParanoid" id="A0A1Y1U973"/>
    <dbReference type="OrthoDB" id="2690228at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="494" mass="52934" checksum="11369D92EB6798AA" modified="2017-08-30" version="1">MVSPLEKEISAAVCKWDFCTDTFASRDALQTHLTAHWKAEVPERVRVKRQKVSLGRWEAADEEQGLERLLPFKQSGDITTTTEGTTLSYVYPPSFPSQAPTLPSFLEDDNSDEIHDSTTKVGKEKARVEKTDSVSGAITASASSISNIVSSLEITTSQAADLFTQPYQPFTPPSSQYTEDVLPSPQVSFAEIYSSQISQMEQNVPGSQEATQALADDLSQLDSLEASAESDEWGCFLEPSQPGKSPMISSSPYVAPSQALPTQTRAGSPIQAETIAMSQIVKSIPMSQESPPGPSLSQMVKSPKTPSKGRSKPASPSRRGKAFVPPRSTQSPQGPKDEPISPATKNVTGKPPSSSPGRKTTASRSSTSSGPVRKRPTWIWITESPELSRKAAPSHSPASHSAAEESLSVENIIHPACGDPTKNIEIGLPPTLRENTSVFNVATPRQRSDSYSRSSLKFGMPYGQGGETATPAAVSSAITPPGSRDVGFTWAQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9K4</accession>
    <name>A0A1Y1U9K4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_168878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868464.1">
        <property type="nucleotide sequence ID" value="XM_022012082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9K4"/>
    <dbReference type="GeneID" id="33553890"/>
    <dbReference type="InParanoid" id="A0A1Y1U9K4"/>
    <dbReference type="OrthoDB" id="2562727at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24289" checksum="3BF499B91AC99A03" modified="2017-08-30" version="1">MPSPLVVRYSGAVLLFIVGAVVLGISVHVEHSTRVLGFKSHTFTYDAFVGAWTILAEIVLAVTRHFFSQTVLATFLVEISVLCLSMIFWLAAGIDTTLFTSEDRSVCKHIDDLFDLPEFENADPQVIQAAKKIFQSACSELHAQLAFIWIGFIVTTLLLGYLVVHALRMKHHGVPNVFQKTLKLSNYIENAPRDPFADPSGNYGVVGAGIAQDEARSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9K9</accession>
    <name>A0A1Y1U9K9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_634611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868960.1">
        <property type="nucleotide sequence ID" value="XM_022016750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9K9"/>
    <dbReference type="GeneID" id="33558559"/>
    <dbReference type="InParanoid" id="A0A1Y1U9K9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="165" mass="18377" checksum="43258023CBA3F978" modified="2017-08-30" version="1">MGCNPYMPRGNPSQMHAAHSPFTPPSLSYGWAFCIASSLLLPLMLLSGVSVNVPLGFAVIVTDRPMPPPASAALFQLWQRDENTLKITKMACRFPIFSFFFIQTARVFFKVDWLSSPSGASSPAHLSLWVCSRRMDESNKGRERKRKKKKTAKTPKLRATSENGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9M2</accession>
    <name>A0A1Y1U9M2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_634721</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868972.1">
        <property type="nucleotide sequence ID" value="XM_022016753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9M2"/>
    <dbReference type="FunCoup" id="A0A1Y1U9M2">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9M2"/>
    <dbReference type="GeneID" id="33558562"/>
    <dbReference type="InParanoid" id="A0A1Y1U9M2"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="505"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="588" mass="64420" checksum="E7D86FC203661629" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9M5</accession>
    <name>A0A1Y1U9M5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative X-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_171940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868485.1">
        <property type="nucleotide sequence ID" value="XM_022012088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9M5"/>
    <dbReference type="FunCoup" id="A0A1Y1U9M5">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9M5"/>
    <dbReference type="GeneID" id="33553896"/>
    <dbReference type="InParanoid" id="A0A1Y1U9M5"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="533" mass="58206" checksum="1637D98553189D05" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Y4</accession>
    <name>A0A1Y1U9Y4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_635283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869081.1">
        <property type="nucleotide sequence ID" value="XM_022016799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Y4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Y4"/>
    <dbReference type="GeneID" id="33558608"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Y4"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="513" mass="57014" checksum="45513EF7BE0EA755" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA68</accession>
    <name>A0A1Y1UA68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869134.1">
        <property type="nucleotide sequence ID" value="XM_022018526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA68"/>
    <dbReference type="GeneID" id="33560335"/>
    <dbReference type="InParanoid" id="A0A1Y1UA68"/>
    <dbReference type="OrthoDB" id="2560796at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="161" mass="17345" checksum="7F6FFC7AF7AA089F" modified="2017-08-30" version="1">MPSSSAPGVSSSERKAIEAAQEKKKKAAKAKAEKLEAYKKKAAPDTVEELVEVGELESKWFKEGEWKPEWALVEFNDDACLANVTKAGKAKDGFFVPAGSILPLGASLPDMTVLKYGGYFPAGTSFQGGVMIPLHARMVNILPEETKEVPTMVDEGLCVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAF5</accession>
    <name>A0A1Y1UAF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869247.1">
        <property type="nucleotide sequence ID" value="XM_022018546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAF5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAF5"/>
    <dbReference type="GeneID" id="33560355"/>
    <dbReference type="InParanoid" id="A0A1Y1UAF5"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52432" checksum="7657B7FA8D17BDE0" modified="2017-08-30" version="1">MVSSSTNPAMDLATAMESHESPGADDPLECEQNPKSTVEMSRLLQLQRTTSAGDSRLLKKGSAESASLAAEDGHSSTGVEELKKALEKATAELAAKRAAEDALVAEQERQKRVEAKRKADREEYHKAGMAAWERRLDEERRAQERAMAILEEKKAIEAKKEREWDPLARKTVYARVPKWDDIPDWGDSTRCHLMELPNEILDLCFGFIEGETDLVTADYVALAGCSRFFRHCLDDDFFFEICHHSRMDLPQLPQPPVNAFYTPSGDRSTWTDAQVEVHDMERRQWQLTTLQNALNIRVCQLKRQFHRSTTTSSVLFRGTKALAIIDGRIAGQPSEDGKEEENIEAAATRLWAHATDPADNKKYAEEVLHTEIEQSAKRLWAKATDPNTRLMAIAKTLLDDPDADVEEQEYPFVVRYNQDGQALPHDYWPSKWRNRAAESVNAEWITKSDAMREFKVTEAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAW1</accession>
    <name>A0A1Y1UAW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_122604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869397.1">
        <property type="nucleotide sequence ID" value="XM_022011962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAW1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAW1"/>
    <dbReference type="GeneID" id="33553770"/>
    <dbReference type="InParanoid" id="A0A1Y1UAW1"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="212" mass="23338" checksum="456E442DC57D40BF" modified="2017-08-30" version="1">MSWEEKWANGRTHWDQGLAHPSLVALLKSDEGRKLVPTQGVAVIPACGRGYDVHLLATHGLRAIGVEISPTGAEAARKWLREQADGLGQYDIVDADFFKWAEDSSSPKANVLLDYTFLCALDPHDRPKWKTAMSAAASPATEATLITIMFPLNSNRGPTEGPPFALSLDLYHELLDDRWELVYLTDIDKGSGMGRHVGPAGDEKLGIWKYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB12</accession>
    <name>A0A1Y1UB12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_82774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869418.1">
        <property type="nucleotide sequence ID" value="XM_022019258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB12"/>
    <dbReference type="GeneID" id="33561067"/>
    <dbReference type="InParanoid" id="A0A1Y1UB12"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="522" mass="55758" checksum="0CB399B44DFED1A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB38</accession>
    <name>A0A1Y1UB38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869448.1">
        <property type="nucleotide sequence ID" value="XM_022016486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB38"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB38"/>
    <dbReference type="GeneID" id="33558295"/>
    <dbReference type="InParanoid" id="A0A1Y1UB38"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013186265" evidence="2">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="244"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="503" mass="56935" checksum="F4D5EAC45C65BFC7" modified="2017-08-30" version="1">MLLLKQVLLLGAVSLVSSVRATLDYEEVLSAIPFKGDSKAGKVYDQVIEQFSAEAIENRHLLHARISNLFPDSAVTVTSDPEFQLLPYAASVPDRIIIREKEDVQALKDVVFSRAHRRRSDTSSVHESVRFAGYDIEWQDQSLQAFIVAWHEDYSLYVQWHLIGDASAAHDLIRECSKWTAEPQNVIWVFNDGFWQPDAALWTAVQKASWSSVILDEEFKDRLINDYRSFFKSEETYKSFEVPWKRGLILLGPPGNGKTISIKAIMKDVDVPKLYVKTFHTWQGDEVGIREVFQRARAEAPCVLVLEDLDSLITDMNRSFFLNEVDGLEDNDGLLLIGTTNHFERLDPALSNRPSRFDRKYNFGNPSWAERRKFALFWQHKLSKNKQIDFPDSLVDKVADGSDNFSFAYLQEGFVASLLTLAGIDDPASRPEFATILMKEINKLREQLRQGNDKSFDNSTLGFDGESGGIGGGGGADPRWLKELQVMRGLQFPVGQVQFGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB60</accession>
    <name>A0A1Y1UB60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869468.1">
        <property type="nucleotide sequence ID" value="XM_022016495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB60"/>
    <dbReference type="GeneID" id="33558304"/>
    <dbReference type="InParanoid" id="A0A1Y1UB60"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="73" mass="8100" checksum="7352DBD714B9701F" modified="2017-08-30" version="1" fragment="single">MLYSSSSPPRLSLSLTFHKSPNSIYPFPLLWSFSSASFFIRRRRRPPAALPLPCVLLASLCVLTSPLAPPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBQ1</accession>
    <name>A0A1Y1UBQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_633000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869668.1">
        <property type="nucleotide sequence ID" value="XM_022016586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBQ1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBQ1"/>
    <dbReference type="GeneID" id="33558395"/>
    <dbReference type="InParanoid" id="A0A1Y1UBQ1"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="561" mass="63119" checksum="AA34D629F3843E65" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBU3</accession>
    <name>A0A1Y1UBU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_633591</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869223.1">
        <property type="nucleotide sequence ID" value="XM_022016636.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBU3"/>
    <dbReference type="GeneID" id="33558445"/>
    <dbReference type="InParanoid" id="A0A1Y1UBU3"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1121"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="455"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1270"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1596" mass="174660" checksum="A566EF1E145E077E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBV1</accession>
    <name>A0A1Y1UBV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_652678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869172.1">
        <property type="nucleotide sequence ID" value="XM_022018534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBV1"/>
    <dbReference type="GeneID" id="33560343"/>
    <dbReference type="InParanoid" id="A0A1Y1UBV1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="29900" checksum="252AA465C2D190E1" modified="2017-08-30" version="1">MKRTIRWYWTPLTPSTDFLSRLLLQTALGRHRLTRHLIRWAPLLAPHDPTALHAALADAERRLEEVTSLLTQERAVWAEKEQAWQARSAAWKQGNWIGQTRQDTGEDDIEKTNNAFETEEEEEDGEFEDLGELFILCANLKQLERDKGRMMEVLAVTTQRQPDYHQEPCNVDDREQSQGDDTGLLAQASSRITELVEEKQVLQGRLDEAFKTISERDMHILHLEESTEDHLQALYIQLAKLQSSLAPAREGYVNGSLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC81</accession>
    <name>A0A1Y1UC81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_631029</name>
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    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869822.1">
        <property type="nucleotide sequence ID" value="XM_022016396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC81"/>
    <dbReference type="GeneID" id="33558205"/>
    <dbReference type="InParanoid" id="A0A1Y1UC81"/>
    <dbReference type="OrthoDB" id="2564483at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1208" mass="131291" checksum="B0F4F8B8071EA679" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCL9</accession>
    <name>A0A1Y1UCL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_632058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869454.1">
        <property type="nucleotide sequence ID" value="XM_022016488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCL9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCL9"/>
    <dbReference type="GeneID" id="33558297"/>
    <dbReference type="InParanoid" id="A0A1Y1UCL9"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012146632" evidence="5">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="99"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="268" mass="28575" checksum="A327016B5C52CA3A" modified="2017-08-30" version="1">MRSILICLLLNTATQSIATARPTVRQDSSVTVLSASQISEWTIPAYLASAAYCPGNTIQSWNCGPACGNVSEPNGIVTGGDGDFVQRWFVAQTSDGTTVLSISGTNTSSIESIGIDIDFPLVEVDETFFPDSTGVELHQGFYGAFKRIQGGILAGVVAQARQGDILVVGHSLGAALTQITATYLQKQFPARVVTAKSFAPPRSGNKAWADYVDVTLGSNTGHMINYADDVPHLPPRPWHFQHASGEIWILKDGTTYEACGGRENPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDD1</accession>
    <name>A0A1Y1UDD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_633857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869301.1">
        <property type="nucleotide sequence ID" value="XM_022016669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDD1"/>
    <dbReference type="GeneID" id="33558478"/>
    <dbReference type="InParanoid" id="A0A1Y1UDD1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440525" evidence="7">
        <location>
            <begin position="38"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="441" mass="47843" checksum="F985E7D4AED6DE5B" modified="2017-08-30" version="1">MLVKTPTGTWLPAWVPQNTMVLMVLLLLCSMVQSATGGYDGSCLNGLNILPAYANYFVLDAATEGLNTAAIFLGAIPANLVGGMITDYFGRRLTIFWFSLGTLVGVILQGAAQNVAMFVVARVVLGFCSGVDGIAAAVYLNETFASRWRTWGAGTLNNFYYIGALIAAGITLGTSKWPNSTWSWRLPSLLQGIFSIICILILPFVPESPRWLVGQERLEEARIVVAQTNSNGDMDDPVSIAVYKEIVDTLHWEKTAGRSMSPLDMFRDKASRRRLLIGASPGVLTSSTGNIIASYYLGDELNTAGITSVLAQLKANVVLNVWCFACAVAGTQFIARWGRKPSAIVCQTLLIVTLYIIGGLSKVYADQTAVNPNGATHAVVYGNVACIFLFQGFYSLVYTPILNLYPVEVMNYSMRANGFAFMQFLLNCCALVLVYVMPIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDI5</accession>
    <name>A0A1Y1UDI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_630251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870247.1">
        <property type="nucleotide sequence ID" value="XM_022016310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDI5"/>
    <dbReference type="FunCoup" id="A0A1Y1UDI5">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDI5"/>
    <dbReference type="GeneID" id="33558119"/>
    <dbReference type="InParanoid" id="A0A1Y1UDI5"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="91"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="415" mass="46363" checksum="D3BF097212D220BB" modified="2017-08-30" version="1">MTRIFTVVGNFWGTKTLIESLSQRPLRSTLPSVRYLQTDADKSEPIGELPKSKSEKFKVRLDSESFHSYRCDVPAAESETSKEEMMEMYKNMTTMRRMEQAADALYKQKLIRGFCHLAIGQEAVSVGMEAAITPDDRVITAYRCHTFAVMRGGTIKGVLAELMGRVDGMSYGKGGSMHIFTPSFFGGNGIVGAQVPVGAGVALAQKYLKNKTVTFALYGDGASNQGQVFEAYNMAKLWNLPCVFVCENNKYGMGTSAERSSQNTAFFTRGDQIPGLQVNGMDILAVKRACEWAKEWTTSGKGPLVLELVTYRYGGHSMSDPGTTYRTREEIQEVRSSRDPIAGLKRYIMDWGVESEAKLKAIDKAAKEEVDKAVEEAKQSPYPDLKEFWTDIYYKGTEPPFMRGREKEEVHHYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDN9</accession>
    <name>A0A1Y1UDN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869800.1">
        <property type="nucleotide sequence ID" value="XM_022016387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDN9"/>
    <dbReference type="GeneID" id="33558196"/>
    <dbReference type="InParanoid" id="A0A1Y1UDN9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="257" mass="28124" checksum="F85319F5D2B85054" modified="2017-08-30" version="1" fragment="single">MDKVKQGAEQVMNKVCGSILQEASPPHPVNSPYDSTTTTKKANLTSQETREDSAATTTTHTVKEAIKEALEATTTTLTDREVTKEALEATMTLPSVPEEATRRDSEETTTVIRSGLVTTTLSDPEATLALTLATNLELEDTEDKDKTRPLVLETKQVDSTLPTRADSVVTRTAPSVVTKVVTTLDPTRTARSEVNRTTRLEASKATRLAETKAVTTSTLTRTTITSVRDRESFTVRKFETIRSNERRSAAMIYEGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDR3</accession>
    <name>A0A1Y1UDR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Pom152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_631845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869405.1">
        <property type="nucleotide sequence ID" value="XM_022016469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDR3"/>
    <dbReference type="FunCoup" id="A0A1Y1UDR3">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDR3"/>
    <dbReference type="GeneID" id="33558278"/>
    <dbReference type="InParanoid" id="A0A1Y1UDR3"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="3">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="5">
        <location>
            <begin position="196"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="490"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="583"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="788"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="902"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="6">
        <location>
            <begin position="1089"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1262" mass="139523" checksum="ADBB123AD9F570EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEP5</accession>
    <name>A0A1Y1UEP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870113.1">
        <property type="nucleotide sequence ID" value="XM_022016251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEP5"/>
    <dbReference type="FunCoup" id="A0A1Y1UEP5">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEP5"/>
    <dbReference type="GeneID" id="33558060"/>
    <dbReference type="InParanoid" id="A0A1Y1UEP5"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="85" mass="9528" checksum="CE81B71EC1691116" modified="2017-08-30" version="1">MSELRYTANTQLEQLHARYTGTGHADTTKYEWMTHQHRDTLASIAGHPPLLAYLAIADGECQARSKFEVIEKMLQPCGKPPGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UES1</accession>
    <name>A0A1Y1UES1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870135.1">
        <property type="nucleotide sequence ID" value="XM_022016262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UES1"/>
    <dbReference type="GeneID" id="33558071"/>
    <dbReference type="InParanoid" id="A0A1Y1UES1"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="51539" checksum="1A05A310D208DA1B" modified="2017-08-30" version="1">MVISRSIFSTSSSTTSSAVHSSAGSSRSVMVSISSTSSKAVSSSSTISRSSSTSSTSSTSSTISSSVASSTSSNIAPPIWSGSYHALPRVTSSPQIQAGSYQRLTSLVPQVLQNAISISTHSWELGILANSLTEVFYPRLAPFSYDYSAPGSSSAIPWSVLDVMTQTLSGYSWSGAPSTRGAPATPLSMYLSSSTSPVGMTNSPLVDGQGALGDPCSLGAGTWIMAEFFGASDVRNVYGSRPGQDFAWAVGNQYQHLEAGVRNSQGTLSQREGYFELWADMGYMIPPFLAYIGMATNSQSMLNDALSQWALECNAMLNTSTGLFDHVPTWDNRPWATGNGWMLMGFMRVVASINSAGQSGQFAQTISNYVGSVTWVFYNLFGNMGSDNLIPNYMKGSGDGTGDASGSAMVAAAYYRFRVLEPQKIAPWLDSRASDLFDAVVNQVDSSGWLHHVVNPEYPWTVYAGQSPEGQSALGLMWAARTAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UET2</accession>
    <name>A0A1Y1UET2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-containing amine oxidoreductase-domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_629890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870153.1">
        <property type="nucleotide sequence ID" value="XM_022016269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UET2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UET2"/>
    <dbReference type="GeneID" id="33558078"/>
    <dbReference type="InParanoid" id="A0A1Y1UET2"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="62292" checksum="DBEE0C5AD97A46BB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEW9</accession>
    <name>A0A1Y1UEW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_452116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870637.1">
        <property type="nucleotide sequence ID" value="XM_022012822.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEW9"/>
    <dbReference type="GeneID" id="33554630"/>
    <dbReference type="InParanoid" id="A0A1Y1UEW9"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1606"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="595"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1453"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1676"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1453"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1475"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1681"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1699"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1785" mass="191444" checksum="E010E064CA76782C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEZ0</accession>
    <name>A0A1Y1UEZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_602686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870205.1">
        <property type="nucleotide sequence ID" value="XM_022013951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEZ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UEZ0">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEZ0"/>
    <dbReference type="GeneID" id="33555759"/>
    <dbReference type="InParanoid" id="A0A1Y1UEZ0"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="167" mass="18848" checksum="3AB0B4C0515E4790" modified="2017-08-30" version="1">MLIYQDIITGDEMCSDSFDMKEVDGIAYECDCAMIIVKEGDVDIGANPSAEEAEEALENGAEQKNNVVHSFRLQATSFDKKSYLTYLKGYMKSVKAKLQETNPERVEAFEKGAAAFAKKIVGNFKDFEFYTGESMNPDGMIALLNYREDGTTPYFTFWKDGLKEYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF11</accession>
    <name>A0A1Y1UF11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870233.1">
        <property type="nucleotide sequence ID" value="XM_022018424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF11"/>
    <dbReference type="GeneID" id="33560233"/>
    <dbReference type="InParanoid" id="A0A1Y1UF11"/>
    <dbReference type="OrthoDB" id="2575740at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="338" mass="35665" checksum="F34099CB059837A1" modified="2017-08-30" version="1">MSNSRPAPYMVALSGWPEPVYIAGPPLGSSRSGTPGPSSGGGEYREGVSRVDIEHHAGKGESSLLPFHLRARPEAWPPAESIFSKTCMYNNDPNKECLVPDHPNHIAKYAQQRSSVIGTPTRAESPAQFPTSSARSTPHPSPPGSRRGSPKPQHLHMPHNSSPLTVSLQDESSSHSSAQCNKSFSDPRYAPHAAVLTNRPALELAPSWASSSVHSGPHHQPSVHPHSTGVGVRVPAGQRGTGILVMRAVPDVYPAPSVPGIAGMAAEMSRTASSGSRRKSRADSGRNPALEVATEVYPRDPDSAILWSSASRKSSMASISVKQQLGAAGEGGMELDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF40</accession>
    <name>A0A1Y1UF40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_651098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870678.1">
        <property type="nucleotide sequence ID" value="XM_022018264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF40"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF40"/>
    <dbReference type="GeneID" id="33560073"/>
    <dbReference type="InParanoid" id="A0A1Y1UF40"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="46"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="467" mass="51477" checksum="EBC3E7C60B522509" modified="2017-08-30" version="1">MQATYSAPAGRAGPSRLNHTARLPRTARKPFVCADHKPQRPDGRFRVVIISSGSVASVKIPDIVGSLSRNHNIDLQIVATKASLHFYNQAKVDEAVRRVLGPGSQSVTDNPTLADDSTGVRVWTDEDEWSDWNQLGDPILHIELRRWADLVLVAPCSADMLAKIAGGLCDNLATSLLRALSPDTQTILFPAMNTHMYSHPLTANHLNLIQEKLGYMVSGPQGGGKLACGDEGPGKMTDWRDIVTIVEDLAVMHRAKFAEARVFRELGPGTHPNPNITYGITSDSVQARRPPLLDPEKVADFEGRSAFRWNGNQPGLGKTQDDPSSSRYLPINVEKTTEAKMDRATAVRTNHLSKLDAMQVDVPSKHPSADETSSSQSAMMLPWLRDYIVEKQTNNTAGSRLERKTEEIMDSRFAPLRTHAHQHDSALAWNGDQAGLSIERNGPLEFTEPYRMAPIPPIDPEETTRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF71</accession>
    <name>A0A1Y1UF71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_580383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870779.1">
        <property type="nucleotide sequence ID" value="XM_022013437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF71"/>
    <dbReference type="FunCoup" id="A0A1Y1UF71">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF71"/>
    <dbReference type="GeneID" id="33555245"/>
    <dbReference type="InParanoid" id="A0A1Y1UF71"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="669" mass="71091" checksum="A5DAD89E265FCD68" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG16</accession>
    <name>A0A1Y1UG16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_581331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870144.1">
        <property type="nucleotide sequence ID" value="XM_022013492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG16"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG16"/>
    <dbReference type="GeneID" id="33555300"/>
    <dbReference type="InParanoid" id="A0A1Y1UG16"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="11">
        <location>
            <begin position="730"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="815" mass="86873" checksum="C54B5DC088809B37" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG17</accession>
    <name>A0A1Y1UG17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_627700</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870988.1">
        <property type="nucleotide sequence ID" value="XM_022016030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG17"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG17"/>
    <dbReference type="GeneID" id="33557839"/>
    <dbReference type="InParanoid" id="A0A1Y1UG17"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="14">
        <location>
            <begin position="320"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="15">
        <location>
            <begin position="430"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="619" mass="69572" checksum="E9F6503CFF16E43F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG82</accession>
    <name>A0A1Y1UG82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_422423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871070.1">
        <property type="nucleotide sequence ID" value="XM_022012736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG82"/>
    <dbReference type="GeneID" id="33554544"/>
    <dbReference type="InParanoid" id="A0A1Y1UG82"/>
    <dbReference type="OrthoDB" id="2581252at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052848">
        <property type="entry name" value="CHCH_domain-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031731">
        <property type="entry name" value="CX9C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47106:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16860">
        <property type="entry name" value="CX9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS import disulfide relay-system CHCH-CHCH-like Cx9C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="111" mass="12400" checksum="5423082111152630" modified="2017-08-30" version="1">MDASYNLVASKCAKQMAQYQNCVLANQDKAWSEICSKESDALTACAEDKVPQLKALKQTCGEHIKSYAECIKTHGHASENQVVQECQNVMRDLWKCTEEVMDKLGSDARLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG85</accession>
    <name>A0A1Y1UG85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_656903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870625.1">
        <property type="nucleotide sequence ID" value="XM_022018852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG85"/>
    <dbReference type="GeneID" id="33560661"/>
    <dbReference type="InParanoid" id="A0A1Y1UG85"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="394" mass="43464" checksum="D8BEBCABC7A88012" modified="2017-08-30" version="1">MSSPIASSSTATHAQPIHGFVGPLSTFPTRPRRASSPFSDASPATPISACAFIFGSHEPARADEFESSLTSPLTPRTSFTSAGSLTRHKSGSDKGSRRALFYIADAEDRDDDQEEHEEDDDEEEEEISHRWGGTQQPSSRAVAVAASYGQRQMFKAVTQSGDRTHSLKALQRRRTPLYPQDGLRRRLNESDESSASTHSPLLLPFFGPTETDSTSCGLKRRPAIRRKRSQSSIYDSMSLSTDSPLWPPSETSHLEGRCTPDGIPFYSLQAHPLRPRKAATIDIHTISTRLGSPVLDRDSEFARHLIDERRITTSPSEDDLTSAQRRSRPASLTIISEESASSPIGWVRRLSKRGRKAKKIGLDGDEKLGGCANSTQAVTGHKRRFSLPSLRFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG96</accession>
    <name>A0A1Y1UG96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_522658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870214.1">
        <property type="nucleotide sequence ID" value="XM_022012991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG96"/>
    <dbReference type="GeneID" id="33554799"/>
    <dbReference type="InParanoid" id="A0A1Y1UG96"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="25436" checksum="9272D2DFF5EB5867" modified="2017-08-30" version="1">MPDDQYELLHGDPSSRTSSDSRVDEASEDTEGTESSNGDDRLVMEGDYLPAQESCTRSLARGVRMTFKSTAGSIMNGLSRTSAALGSCADGTCNGVWSCFVPIRTYHTISARNYWAGGLIQSAETIATCPIMKWDGRPYVDVTVNGASCLLKSTVMCPFVCAGLILLWPGQSQEDCQDCFCDCCPDALEEGKSKYPPTRANDTQTVVREPPAPRDEVMQTSGQSALGDTEGITSAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGE4</accession>
    <name>A0A1Y1UGE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_427163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871161.1">
        <property type="nucleotide sequence ID" value="XM_022012754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGE4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGE4"/>
    <dbReference type="GeneID" id="33554562"/>
    <dbReference type="InParanoid" id="A0A1Y1UGE4"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="4">
        <location>
            <begin position="158"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="3">
        <location>
            <begin position="306"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="741"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123544" checksum="E3B3F42586B87ED3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGJ3</accession>
    <name>A0A1Y1UGJ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_600855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871218.1">
        <property type="nucleotide sequence ID" value="XM_022013922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGJ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGJ3"/>
    <dbReference type="GeneID" id="33555730"/>
    <dbReference type="InParanoid" id="A0A1Y1UGJ3"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33390" checksum="4DD2E16731144460" modified="2017-08-30" version="1">MLLNLPPELILKIHLHALNPSFPSTHPQIHSILTRPTPSFAATYLLSLYETNGPSDILTRSLRHPICNTDVAQELRRMWDRRRGHSPLKAWGASTRSRSNPADGPDDREATSDPTAPPLTCSELPRRIFRSPLPEANPLLHYLFDHYSPSPNSHKGYPLCRAVLNSDYALIDFLLRHGADPALKSNLVLEIAIKKNDLKAVRMLIERKSEDVPFDDVSGTEHGRDRGRKKRRKLSDRVSITPRLVQIALQCGSQDIVHYFVEDKGVIPPLHGILAMSSPTKPVRLGRVRPFGSPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGL4</accession>
    <name>A0A1Y1UGL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_625165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871239.1">
        <property type="nucleotide sequence ID" value="XM_022015775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGL4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGL4"/>
    <dbReference type="GeneID" id="33557584"/>
    <dbReference type="InParanoid" id="A0A1Y1UGL4"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="948"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="254"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="980" mass="108803" checksum="B22E2668A2D5C9EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGV8</accession>
    <name>A0A1Y1UGV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870805.1">
        <property type="nucleotide sequence ID" value="XM_022018297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGV8"/>
    <dbReference type="GeneID" id="33560106"/>
    <dbReference type="InParanoid" id="A0A1Y1UGV8"/>
    <dbReference type="OrthoDB" id="2576006at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="45803" checksum="81D0C90D30C64AB1" modified="2017-08-30" version="1">MTLPSIGPNTSDRELTSSHRIELDQLSQTLKSVREQLAPPSTLFPKIDALSVEPSRVHHSTPAPLPTWSPSPGLTAPSTPRRTSRDQIGSLRPKFSTRLSSALRLSKNLSNIGKRKKSSFQIESQGLLADLNDASPLGTPSPPLSSPGTESEPISAPGSCRKHSAVSDTTLVDRDSATSLLDTLAPLISGIQQASKRITESTFDQIENEAVENRQRFTTLCAETVTFLISLIGEKRSPCLEIDHEEDMRKLMVMALVKKVEFEIQAVSQNLDASVTPDLLPVASPSLLSTPPQVTALSRSRSRSRSSSSASSSIAGDHPSNPFVLHTTSLQSGHHAKPPARQSTPGHSLGVDSELTLGGRKQSVSIPIGSGDPAGANVNPPAHPGSFYAFVGGAQSSLWATNVRLASFQNSLLFSPSPIAVRRVVGYGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH25</accession>
    <name>A0A1Y1UH25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871388.1">
        <property type="nucleotide sequence ID" value="XM_022015841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH25"/>
    <dbReference type="FunCoup" id="A0A1Y1UH25">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH25"/>
    <dbReference type="GeneID" id="33557650"/>
    <dbReference type="InParanoid" id="A0A1Y1UH25"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="222" mass="23782" checksum="B1301B09830217B7" modified="2017-08-30" version="1">MASLPQYYNILNVSPTATADEIRAAYKRESLRTHPDRLPGNATAQQKRKATEKFQAVADAYYVLSDPARRAEYDSLFHSRPPGAFTDDGASEYEQDQASSSFFQNFSQYFGNSTNATGNAGTGQARPDPNGVFGDVFEEMLAPEVANVRPWWGYLGGASGAVMGYIVANVPGAIAGGFAGNRLGSIRDAKGKSVAQVFAGLGHSQKAEILRALAFKVLGSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHF7</accession>
    <name>A0A1Y1UHF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High-temperature-induced dauer-formation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_627728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870995.1">
        <property type="nucleotide sequence ID" value="XM_022016036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHF7"/>
    <dbReference type="FunCoup" id="A0A1Y1UHF7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHF7"/>
    <dbReference type="GeneID" id="33557845"/>
    <dbReference type="InParanoid" id="A0A1Y1UHF7"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="982" mass="107470" checksum="F46CD7E56E25014E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHN8</accession>
    <name>A0A1Y1UHN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_650144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871558.1">
        <property type="nucleotide sequence ID" value="XM_022018106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHN8"/>
    <dbReference type="FunCoup" id="A0A1Y1UHN8">
        <property type="interactions" value="244"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHN8"/>
    <dbReference type="GeneID" id="33559915"/>
    <dbReference type="InParanoid" id="A0A1Y1UHN8"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="457" mass="48576" checksum="2566A841079DA96C" modified="2017-08-30" version="1">MAESSSSGSSGAESIAIAARRAFEESQLVDPAERNVALRAIHKILNERREEVLEANQKDMEAASALVDQGKLSSTLVSRLDLSRAGKYESMLQGVMDVAALPAPTGLVTFAKELGPGLELHRVTCPIGVLLVIFEARPEVVVNIAALAIKSGNAAILKGGKESIHTSTLLSNLIAQALSSTSIPPTFIQSVSTRSQISSLLAQDKYIDLVMPRGGNELVKSIQNSTRIPVMGHADGICAVYLDESADEQTAIRVTVESKIDYMAACNSAETLLVHESILSSVWPKVAVALMEKNVALRCDPSSLDALQHIQLAAVNCTASTPSDYTTEFLGPTLAVKTVPSTAAAIQHINAHSSHHTDSIVTQSEASMSTWCRGLDSANCFINASTRFADGTRYGLGTEVGISTGKTHARGPVGLDGLVIYKYMMRSTVAGGSLISDHEKGGRGYTHTDISREKPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHQ2</accession>
    <name>A0A1Y1UHQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_599809</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871577.1">
        <property type="nucleotide sequence ID" value="XM_022013910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHQ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHQ2"/>
    <dbReference type="GeneID" id="33555718"/>
    <dbReference type="InParanoid" id="A0A1Y1UHQ2"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="205" mass="22811" checksum="05D433ECD75B148D" modified="2017-08-30" version="1">MSRAISTTCVLRRTSTLSHRIIRPVAVPDRDSTSFQTTSRPRLLSISARPSSSRSNRPSCIPLRALHVSSSSRSSSGGEASSKSLTASEYERISEQDMDTLHDELEELCEVYAPEDWEVEYSSGVMNLSVPSTGTYVINKQPPNQQIWLSSPLSGPMRFDYGPDGVWVHHRKSDVTLGRILDKELRDLLSETGVEESDWKGVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHY9</accession>
    <name>A0A1Y1UHY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_601451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870774.1">
        <property type="nucleotide sequence ID" value="XM_022013932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHY9"/>
    <dbReference type="FunCoup" id="A0A1Y1UHY9">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHY9"/>
    <dbReference type="GeneID" id="33555740"/>
    <dbReference type="InParanoid" id="A0A1Y1UHY9"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="10">
        <location>
            <begin position="158"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="416" mass="46595" checksum="BD553A35ACBD6099" modified="2017-08-30" version="1">MYFIEESRWRGVSEQDEEDNFWDLPAPEILPVREMLESLLGVNVLAPLVRCSKLPFRHLCSLYETHITHTPMILAQEFSRSQSARMSDFSTSSDERGVFWMEPKASASFSREVDENRGSNGSTSSNRGQRTYYEPGPSTRLPPMPIPPTKRSRLVRGALVAQFASPNAEHLADSAELVARYVDGLDINCGCPQSWAYKEGVGCALLRKPELVHDMIRQVKGRMGWNWPVSIKIRVDPELKLTDQLVKNALAVNVSHITVHGRTRFQKSSDPVSLEGIKFAVESTSGQVPCVGNGDIWSYQDVARMREATGVHGVMAARGLLANPALFAGYETTPAHAVEQFVNLSVDYGFIFPLFQRHLAYMMEAHLLRAERTWFNSLPSTISTIDYLSGRGLNVGRAQKMSPVWDARRGRTLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI16</accession>
    <name>A0A1Y1UI16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_651218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870804.1">
        <property type="nucleotide sequence ID" value="XM_022018296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI16"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI16"/>
    <dbReference type="GeneID" id="33560105"/>
    <dbReference type="InParanoid" id="A0A1Y1UI16"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="74540" checksum="512E38539B534CC1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIH9</accession>
    <name>A0A1Y1UIH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_680709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871818.1">
        <property type="nucleotide sequence ID" value="XM_022019091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIH9"/>
    <dbReference type="GeneID" id="33560900"/>
    <dbReference type="InParanoid" id="A0A1Y1UIH9"/>
    <dbReference type="OrthoDB" id="10448283at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36993" checksum="E2B19872A834FBD2" modified="2017-08-30" version="1">MPNTTSTNLANATTIANATQIANATVINTSMIKVPVTFSSPTPFTTTLEVAQTAITKIVTNVTQSVIETEIPVTIKDGAVTLVQTTIPVPVPSESAPAAKTPVAGIAALSAVLGVVIIMACIAVLLLLRKLRNAESSNEIDQHHLYSSPELDKTEEGPTVKQLQDQLTSVRRELASVMVLTPSTIRDRSDYARDLDLINDDIRQISMRITRNSSYSTAPKVRNVLCATLRSEILTRFDASLKPEDDAKFSEVMSRFPRKQSALLWKAMAVQNLPVADARPFAEKLVMQLSLAVGESVHKEELTAMTKNVLSLVRALAEDAKGYSLTVGKDGQQLGLIEPTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIL1</accession>
    <name>A0A1Y1UIL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_650364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871806.1">
        <property type="nucleotide sequence ID" value="XM_022018134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIL1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIL1"/>
    <dbReference type="GeneID" id="33559943"/>
    <dbReference type="InParanoid" id="A0A1Y1UIL1"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45020" checksum="CE7BBD14E436C995" modified="2017-08-30" version="1">MTSEHELRDLSECTLVAANHKQFLEWCTAGMVPWGAHLSPERYITDSERDFKEDWGKDGALQVWALVRRDDPQGSILSACATQRRTGLVKRKGSSEVEKSHVYGIASVVTPVQNHKRGYASHMLKLLHYILADPSLIPSFPELWGQPPQAPDRKVIPYGIASILWSDVGSIFYSKCTIGQTRPGWVMPETKQSEIIWKTRAPALQEGDERWERIRPTELPSIGQELRQSSVDALKSVDTSSKTVYTTDPSSVGLLDFIPLRGSWTWEDKDFNTADPCGLRFRSEYNGGSQDTIIIFGTFNASLGRRTLITYVHNLDPRDLSSLLRVIDAIAFPLDQKEGWIFGLEESRHAELIKAWQAESGREAKYGHRAEVMGHLLGVAYYGPEGEHELLDPQMYSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIY9</accession>
    <name>A0A1Y1UIY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871926.1">
        <property type="nucleotide sequence ID" value="XM_022015639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIY9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIY9"/>
    <dbReference type="GeneID" id="33557448"/>
    <dbReference type="InParanoid" id="A0A1Y1UIY9"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="211" mass="23297" checksum="8CAA4F38A62E9D6D" modified="2017-08-30" version="1">MIPRPLTNRNTVLLICDIQEKFRHAIYGFDSVVHTTLKVLKCAKLLEIPAIVSEQNPKALGSTVDTLVSEIQALPSHSTFSKTKFSMIIPEVEEELKKAKYENAIILGIESHVCVLQTTLDLLRSNISVYVLADGISSCNRQEVPIAMDRMRQAGAYITTSESILFELMNDAKTSVFKPLSAIAFNKDEKATTRETLETLLDGGAVPKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ21</accession>
    <name>A0A1Y1UJ21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_425839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871143.1">
        <property type="nucleotide sequence ID" value="XM_022012749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ21"/>
    <dbReference type="GeneID" id="33554557"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ21"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="364" mass="39107" checksum="DE25DF2DB6B0C746" modified="2017-08-30" version="1">MAQDVDEVDEIHPNAKEDEEIPSSHPRPTSWAGTSSPKEATASSKVVKPKSLPRPISPSPMRNRPPLLVPAASKLGKASGGVTPKPASKGATVKPQTKGKAESSKAKAGAEAGKKIEVKRVQKTKDPVGPVVHGKPVEAMTPHDETDEAKDRQKDRGLDQAKVQDARMETEKGSNLDESENVHKLEDDVDKAREQSRDRNANFQPEIKATKSGSAPKAKVSTRLSRDSPSEVSTQEIRTKSAGNAKTKSRTTSLSSAGSNETRSSKGRYTVEVVIPIKKARSGSDASDSRKSEPRGVKAAKSAKVTKRAAEGDRVPQKPSKMKGAKKEIAKAVKKGTTKSSKKAEDEEMLETQDQLDINMQEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJK5</accession>
    <name>A0A1Y1UJK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biotin-protein ligase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_625643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871343.1">
        <property type="nucleotide sequence ID" value="XM_022015818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJK5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJK5"/>
    <dbReference type="GeneID" id="33557627"/>
    <dbReference type="InParanoid" id="A0A1Y1UJK5"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27013" checksum="535B80E9C899C12E" modified="2017-08-30" version="1">MVEHPVAAVYRGPISSEGCPESLAKLLRHAPAGFKVHYLGPDEDEDVTAESLSKVDLFAWPGGGDEVKRDYKKVARYTKAIQDFIRDGGLYAGICLGAFLAKGEPSEGAFFNLLPSGSYVNCERFEKGSQVKSDKDSVIQTDWHFHSGPKKGTREKRWQYFQDGANIVLGADLKSEAMILGRYSKTGDPCAVVYRLGSGAVGLIGVHPEAEKDWYEDWDGHNPDGIQFDIGHDFVQTLWNLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJU4</accession>
    <name>A0A1Y1UJU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mis12-Mtw1 protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872245.1">
        <property type="nucleotide sequence ID" value="XM_022015281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJU4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJU4"/>
    <dbReference type="GeneID" id="33557089"/>
    <dbReference type="InParanoid" id="A0A1Y1UJU4"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="599" mass="65179" checksum="01F57976F818B5D6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK61</accession>
    <name>A0A1Y1UK61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_623545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="8">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871843.1">
        <property type="nucleotide sequence ID" value="XM_022015597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK61"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK61"/>
    <dbReference type="GeneID" id="33557406"/>
    <dbReference type="InParanoid" id="A0A1Y1UK61"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="67"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="502" mass="57385" checksum="DCD62B26041CCC55" modified="2017-08-30" version="1">MASDHPSAKAPAKTMLNLGNLPPKMKPQDMKLTQNQYPRTPSRVNPNQPPWPAYRGYHEYSFAHATMGVRLPTILGKAIDDVWKTLNQEYDEDKITDLIDCVHRMEDLMGDLQGNSKLRFIVDDGAGDVPLWNKEIAKFFRGKDFMNAPWLFAEAYKYRRLRECFSLSRYWVDYDVFFRQKCDTFSRSSQAVFELSTRFSEPQVLGPNLTEAEIKEKNKLIFLELTQVCLWGNSTDLSLLIDMTEEDIKKLQSTGGDHLAATEKNILGNDLHKLADYVSTIKNGRIDFVLDNAGFELYCDLVYADWLIQSGTCSQVIFHGKKLPWFVSDVTKKDWEWLLNSCTYGQLFGDAKDEEMESLRTLGRRWKQYEKEGKWKYEAHPFWCTGYTFWDLHSEAPDLFQYLSESNLVIFKGDLNHRKLTYDCHAPLTTPFPMAIGPLASEPGAPPICSLRTIKSDVVVGIPSGVGERLDEEEPGWKISGKYAVVLLSPGRSGEQPVYKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKC9</accession>
    <name>A0A1Y1UKC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_623851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871913.1">
        <property type="nucleotide sequence ID" value="XM_022015633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKC9"/>
    <dbReference type="FunCoup" id="A0A1Y1UKC9">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKC9"/>
    <dbReference type="GeneID" id="33557442"/>
    <dbReference type="InParanoid" id="A0A1Y1UKC9"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="708" mass="79698" checksum="260E317464E60AB3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKR0</accession>
    <name>A0A1Y1UKR0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872563.1">
        <property type="nucleotide sequence ID" value="XM_022018073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKR0"/>
    <dbReference type="GeneID" id="33559882"/>
    <dbReference type="InParanoid" id="A0A1Y1UKR0"/>
    <dbReference type="OrthoDB" id="2575571at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="44911" checksum="B950084E7484324D" modified="2017-08-30" version="1">MTTAMMTSSSSALHAPSSAHCSRNPSPTSSPSLLPLASSMAKSSPSHSPLPAPRLLPSTTTTSSSMTPSSTYNSSAPSTSNSNGYDPSRLTPPASPQMISSRSFARAPPVRPYQSPLLSRSTTGGGKPLKPVEGDTRAFAEQVVHLFRQRTDHSRRGQSEYRPEPRDDQGRKRQGRSLGGSLSDTWDGEKVEFIVDIPVWSPGSFQDLSTLHALRDTTLSHTHTLIAYLQSVHSLPASYRLLARSAAPSSVPGSPRAVPTSRPVSPAPTHTHLTVGWGCIRLSPGLASPTMPKKELKPHVRRSSVVVGKSRSRSRSYSKQQPASSRSPKASMDVPEFRLDLDSAIIDEPEDEEYFKIQLKEGYRSGGSAAGSVNGSDDDLEEESADSIIAREVERRKVKEGSAFLMTLFGQPALILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKT8</accession>
    <name>A0A1Y1UKT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_608065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872590.1">
        <property type="nucleotide sequence ID" value="XM_022014099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKT8"/>
    <dbReference type="FunCoup" id="A0A1Y1UKT8">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKT8"/>
    <dbReference type="GeneID" id="33555907"/>
    <dbReference type="InParanoid" id="A0A1Y1UKT8"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="383" mass="42450" checksum="2DB01E75851E167C" modified="2017-08-30" version="1">MSSKPFVAQWGVVGCGWISSEFVMDITRPTSLRKVSDVSHALAAVGSRSLPKAEDFISKYCPDGACGQKDGLVDFKPRAYGSYKEVADDPNVNIVYVGTMNTSHYDDAKMALEAGKHCLLEKPATLNAAEWKDLSGLAKSRDLFLMEAVWTRFNPVMLAIQQAVHIDKVIGDVHVVRSDHSMDLYGKQPDTHRCLSADLAGGPMLDVGPYPMVWSLMMLFRHPKNDMSPPEKVAGTMLLHSTGVDLATGWTMTFPKIKAIAYCTTNLFEDTDKKAHTRIVGSEGEIVVQGHTSRPVGYTVRRLIDPSRSDGKYHPDEVHDMGFEGFGLSWEADQVARCLKAGLTECPTMLHKETQMTMEIFDKLRLEGGYHYLPGLERIPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKY2</accession>
    <name>A0A1Y1UKY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_650046</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872623.1">
        <property type="nucleotide sequence ID" value="XM_022018084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKY2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKY2"/>
    <dbReference type="GeneID" id="33559893"/>
    <dbReference type="InParanoid" id="A0A1Y1UKY2"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011824474" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="216"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="50034" checksum="3DCA0993858E8C0F" modified="2017-08-30" version="1">MRTNALLALLGLLPCLLGSPLQPKSQLSFSSKDLSAQHVVDESIYMAMERYDDPVLALLSIQPELAETLAEKRLIQVFGDDGPVWMTEGDKLRLRRERKKFMDVTDFHDDSLHASAIVPQEPHMPPFTQHAWVKPCFEDVDTNHMRDVLTHMTSYYNRYYHHVNGARSATWLHNHILDIIKESPFQTYISLEYHTHWFMQPSIIARFEPPIRNASAPLTIIGAHQDSANYAFPLLPAPGADDDMSGSVSILEAFRVLAMRGFIPERGPVEFHWYAAEEAGLLGSQAIAKYKKDQQATIGAMMEFDMTAFIFRNATESINFIIEQSNSNLTNWAVDLSKEYIDLTTRVLSSMGPNAGSDYMSFTQQGFPAAFATEGDPSTKHSPMGDFDPYVHTDRDRMDVDNELGVFSIDHMAQFSRLAIAFAVEQAKWSTQHRRERDGTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKY9</accession>
    <name>A0A1Y1UKY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872564.1">
        <property type="nucleotide sequence ID" value="XM_022018074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKY9"/>
    <dbReference type="GeneID" id="33559883"/>
    <dbReference type="InParanoid" id="A0A1Y1UKY9"/>
    <dbReference type="OrthoDB" id="2576298at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="284" mass="31458" checksum="5A3D9FA03FDA0927" modified="2017-08-30" version="1">MSEPFDIPHLAQCFYAAMILPHLARQKSQRRGRRRRQLGLGDVFTITDAKDDHADEETTRTRGRTTTQVKPSTSSVSVRPSSLTASTSSSLSLGTLSQASSSLGSSISTNISSSTSSTSITLHSTSVSTITPIETSSAASGSLIFPNVIPSDFPVPHFRDEDHGEIGRGYLILRTNQLADSMIIFGMSLSFFFIFSIFLVKCSRLLERRQGNIKVDGMVSADMRWAEGREVIEKRIVYEPLGSERRRIMERARPENIRMSTMSQSERRRHLPSGQASEIGRQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL25</accession>
    <name>A0A1Y1UL25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_621950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872611.1">
        <property type="nucleotide sequence ID" value="XM_022015427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL25"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL25"/>
    <dbReference type="GeneID" id="33557236"/>
    <dbReference type="InParanoid" id="A0A1Y1UL25"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="98" mass="10753" checksum="A91038B9E414751D" modified="2017-08-30" version="1">MPKVDPDAKIQCPDAATLQIEIDILAQVLDLGEREDTWEKLEKGLIRFAGVTRGGGYKHLPLFVDALGRGRGRTALGPQVVACVSGDLRKRRMRNAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULD9</accession>
    <name>A0A1Y1ULD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.131</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Asparagine-linked glycosylation protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_617618</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872733.1">
        <property type="nucleotide sequence ID" value="XM_022014939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULD9"/>
    <dbReference type="FunCoup" id="A0A1Y1ULD9">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULD9"/>
    <dbReference type="GeneID" id="33556747"/>
    <dbReference type="InParanoid" id="A0A1Y1ULD9"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="331"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="591"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX38870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="799" mass="88881" checksum="80BDDCF3770E844E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULQ7</accession>
    <name>A0A1Y1ULQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_680209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872399.1">
        <property type="nucleotide sequence ID" value="XM_022019070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULQ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULQ7"/>
    <dbReference type="GeneID" id="33560879"/>
    <dbReference type="InParanoid" id="A0A1Y1ULQ7"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="180" mass="21067" checksum="D2D3C41E476541E8" modified="2017-08-30" version="1" fragment="single">MQAGISVLFDLLRLERQIMLKYVFFYGWEVTKDCPISRACFSQWYDAAFEDPERPGTVFKTAEHWFMFHKARLFDPDLCDKIIAADTPDEAKKLGRQVKNFDRKEWDKYADQVVQKGNELKFAQHADLRRYLFDTGSRTLVEAAPTDRIWGIGFSEDEAMDHVKEWGTNRMGLALTRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULW2</accession>
    <name>A0A1Y1ULW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_360422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872406.1">
        <property type="nucleotide sequence ID" value="XM_022012579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULW2"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULW2"/>
    <dbReference type="GeneID" id="33554387"/>
    <dbReference type="InParanoid" id="A0A1Y1ULW2"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="220" mass="24280" checksum="1206DCBE97DCCE88" modified="2017-08-30" version="1">MRGVAGSEYEGGLYHLRIILPHNYPMAAPDIILLTPNGRFELGKKICIDGLTSFHAGSWQPAWGVRTALTGLRSFWMQGGEALSAIGALDCSREERRRLAKLSQQWTCPTCQVSNNQLLLPTREGPVHAEKSRKEKTDETEIGRQERVEMPLTPSREESDPKEPILPPQQPTISPESPATGIVPQADSPVPSIRPVPKWIDIPLGILCAILGILVVRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULZ2</accession>
    <name>A0A1Y1ULZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_649114</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872882.1">
        <property type="nucleotide sequence ID" value="XM_022017939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULZ2"/>
    <dbReference type="FunCoup" id="A0A1Y1ULZ2">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULZ2"/>
    <dbReference type="GeneID" id="33559748"/>
    <dbReference type="InParanoid" id="A0A1Y1ULZ2"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="175" mass="19928" checksum="E654EE4EEFF188F1" modified="2017-08-30" version="1">MSRFAGRSLDRIWFYFFVMHIPISLAVDFQALYPPSWIVNTPLPAFIKWYMGWSRDPVILGALGGSPLWHWMKAFFWLEAVFQLPCWILGAWGMWTNDKRVYPLLLAYGASTATTLLPTLQALFTVPSTPPLSTLELANLLGCYVPYLLIPLGIAMDMSIRLHRIIAHSQARKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMX8</accession>
    <name>A0A1Y1UMX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_577472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872407.1">
        <property type="nucleotide sequence ID" value="XM_022013261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMX8"/>
    <dbReference type="FunCoup" id="A0A1Y1UMX8">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMX8"/>
    <dbReference type="GeneID" id="33555069"/>
    <dbReference type="InParanoid" id="A0A1Y1UMX8"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="41"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="522" mass="59442" checksum="704D16A82452E709" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMZ0</accession>
    <name>A0A1Y1UMZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_619681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873291.1">
        <property type="nucleotide sequence ID" value="XM_022015195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMZ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UMZ0">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMZ0"/>
    <dbReference type="GeneID" id="33557003"/>
    <dbReference type="InParanoid" id="A0A1Y1UMZ0"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="142" mass="16726" checksum="7113FE0DF0B04C46" modified="2017-08-30" version="1">MSYFMTHLHSGWHVDQAILVEEDRVVCIRFGHDHDPDCMAMDETLYSVSEKVQQFCVMYLVDITEVPDFTKMYEIYDPCTVMFFYRNKHIMIDLGTGNNNKINWPMTDKQELIDIIEVVYRGASKGRGLVVSPRDYSTRHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN30</accession>
    <name>A0A1Y1UN30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_333592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873323.1">
        <property type="nucleotide sequence ID" value="XM_022012517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN30"/>
    <dbReference type="GeneID" id="33554325"/>
    <dbReference type="InParanoid" id="A0A1Y1UN30"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="829"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="868" mass="94552" checksum="082484F328D9369A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNX3</accession>
    <name>A0A1Y1UNX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_614806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873526.1">
        <property type="nucleotide sequence ID" value="XM_022014648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNX3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNX3"/>
    <dbReference type="GeneID" id="33556456"/>
    <dbReference type="InParanoid" id="A0A1Y1UNX3"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="56"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="254"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="696" mass="78116" checksum="5F0D770C12FA6F24" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNY8</accession>
    <name>A0A1Y1UNY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF 4e-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873120.1">
        <property type="nucleotide sequence ID" value="XM_022017974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNY8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNY8"/>
    <dbReference type="GeneID" id="33559783"/>
    <dbReference type="InParanoid" id="A0A1Y1UNY8"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="71420" checksum="C0F1C7FDEADA1F99" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP13</accession>
    <name>A0A1Y1UP13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Intracellular protein transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_614875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873544.1">
        <property type="nucleotide sequence ID" value="XM_022014657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP13"/>
    <dbReference type="FunCoup" id="A0A1Y1UP13">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP13"/>
    <dbReference type="GeneID" id="33556465"/>
    <dbReference type="InParanoid" id="A0A1Y1UP13"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="428" mass="48625" checksum="5A3D86AC9E7EB3AA" modified="2017-08-30" version="1">MISAFFIFNQKGEVLISRLFRTDLKRSISDVFRIQVISNPDVRSPIITLGSTSFFHVRINNVYVVGVTKCNASAALVFEFLYRFIQISRAYFGKLDEESVKNNFVLIYELLDEILDFGYPQNSEIDTLKMYITTESIKSELAVREDSSKITIQATGATSWRRSDVKYRKNEAFVDVIETVNMLMSKDGAVLRADVDGQILMRAYLSGTPDCKFGLNDKLVLQKRGADQGPKSDDAVELDDCQFHQCVRLGKFDSDRSISFIPPDGEFELMRYRSTTNINLPFRLQTHVTEPTKSRVEYTIHLRASYDPKLNANNVVVKIPTPLNTTNVQAKVGVGKAKYVPGDNFIVWKIPKLQGSQECTLTAEAELATTTHRQPWSRPPIQVDFSVVMFTASGLLVRFLKVFEKSGYQSVKWVRYLSKANGSYQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP74</accession>
    <name>A0A1Y1UP74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_648453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873618.1">
        <property type="nucleotide sequence ID" value="XM_022017841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP74"/>
    <dbReference type="GeneID" id="33559650"/>
    <dbReference type="InParanoid" id="A0A1Y1UP74"/>
    <dbReference type="OrthoDB" id="2587581at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="84"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="635" mass="68925" checksum="19FDBF6B6D21320A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPE9</accession>
    <name>A0A1Y1UPE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_244216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873715.1">
        <property type="nucleotide sequence ID" value="XM_022012262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPE9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPE9"/>
    <dbReference type="GeneID" id="33554070"/>
    <dbReference type="InParanoid" id="A0A1Y1UPE9"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18905" checksum="A2FBD3EAACE2B665" modified="2017-08-30" version="1">MADNSILYISDLYWWTNADHIVEAAAKAGIKLARTDITFAEHKVNGKSKGNVLVECHSIHNSVKLFNWFRHNDFHGKRLVPSYYSPQPGPKQHFHSYGPRPATGTQALLAHGPTNAHGGINFNRVRPNVRSGVALKHTLRESGSANEFPAKYTRAPRTAFRPRRLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPL4</accession>
    <name>A0A1Y1UPL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_249543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873785.1">
        <property type="nucleotide sequence ID" value="XM_022012281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPL4"/>
    <dbReference type="GeneID" id="33554089"/>
    <dbReference type="InParanoid" id="A0A1Y1UPL4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012982707" evidence="2">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="216" mass="21685" checksum="5FEBADF73E24CB5B" modified="2017-08-30" version="1">MVYSRFISALVLLVGSGESVRRNPRTEICPAVALAAPFSQMEASAGGLAPSAPEGSAALPGPSGSDAGFDPQPSGGDTSLNPQPSGAENGLTAQPSGLETGLGPQPSGSGSGSGSGSGAGTGVQPGGEGEKQRQRPHWWNQFFSWSSDSGDGQGDTYHDNEQYSYTNAYSWTADGDGNTSGWTMQDGFTSGVEGVSTVQGGGGSVMPMSAVPTGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPP4</accession>
    <name>A0A1Y1UPP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_679068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873786.1">
        <property type="nucleotide sequence ID" value="XM_022019026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPP4"/>
    <dbReference type="GeneID" id="33560835"/>
    <dbReference type="InParanoid" id="A0A1Y1UPP4"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38100" checksum="D59033771AC00A2B" modified="2017-08-30" version="1">MPIQLKTQLVDSVQGSIKLLGGTERDLEWKDQLKREGWCVVKGVLSTGKAKQYEDGAYEFLESFDLGFDRHDRSTWVAERMPYFYKGGLIYAYGSGHEQFVWDVKQDPAVVNVFAEIWGTDELVVSYDGFNFSLPLPDRPEEDFKAWAHVDQSPLVTGFHCLQGIVNILPNGPEDGGLMVLKGSSALYKELWRAFDEHIGGWNKHDRHDHTPEQIQWLLDHGCEWHKVCADPGDLLLWDSRTVHYGATPTSTNPRLASYVCYKPARMVTPELKAKRRLAWDEKKETTHDPITFTANRREPPEDHPTFGHLKVKQLQEPRLTALGRKLAGLDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPR1</accession>
    <name>A0A1Y1UPR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_607140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873788.1">
        <property type="nucleotide sequence ID" value="XM_022014052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPR1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPR1"/>
    <dbReference type="GeneID" id="33555860"/>
    <dbReference type="InParanoid" id="A0A1Y1UPR1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF76">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="788" mass="87133" checksum="FF216769D12180B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPU3</accession>
    <name>A0A1Y1UPU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_616173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873863.1">
        <property type="nucleotide sequence ID" value="XM_022014800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPU3"/>
    <dbReference type="FunCoup" id="A0A1Y1UPU3">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPU3"/>
    <dbReference type="GeneID" id="33556608"/>
    <dbReference type="InParanoid" id="A0A1Y1UPU3"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="135" mass="15103" checksum="6DAE145BBD51826E" modified="2017-08-30" version="1">MSDKEADDDVGLPKATVFKLITEMLPPDMSCSKEAKEIIVECCVEWVKLISTQANTVCEESTKKTISPEHVTEALKQLGFEGFIEEVEESNKAFKQSQKERQRSAPDTNGMSQEELLALQERLFASSQARFEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ42</accession>
    <name>A0A1Y1UQ42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_259470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873904.1">
        <property type="nucleotide sequence ID" value="XM_022012307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ42"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ42"/>
    <dbReference type="GeneID" id="33554115"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ42"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="385"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="485" mass="52020" checksum="4EB2ABA65D0B93B0" modified="2017-08-30" version="1">MSSCVNSASPPPPNLTSAIQTTHLLYTTSPSPSYLPLEDIIDYSSFPFLDNVQDELSMDHLFSQVPQQGENRSSHNLPPPPHEPITSTRNSQVPYQGGQSPTESKADDQDVPMGVVEAREQTYPSALPIPIGGNLPLPPPPSVPYDLGPYANMYGYTPMVVSETSHPQPMMFHPYRFDGYRSPPRWANSPEHHSPQSISPPGSSHSPMNHPALSQSGSPIQAGSPPLVSPTSGLGSMSDVSPGSAVWAYNLPQAAGSVGSLGGYVNTPLTSISALPNMPSGSPPGSTTGSITRMFAGMPYYSAATGATPPKSALLLSGAHPARPKVHKKSGSTSRRDKEFSKSVSKPEIDSDVGGDEVEQDDQIPPIGKSIFTPEDLRSPNLTEEVRKARIKSEQRRRDELRDGFTRLREALPASNQRPSKSSILDRAVAHIQQVESANHYLMNQLDEATKDTKKLQESNAELVRALAASTQTRAPSSPGSSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQK6</accession>
    <name>A0A1Y1UQK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_238302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873622.1">
        <property type="nucleotide sequence ID" value="XM_022012251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQK6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQK6"/>
    <dbReference type="GeneID" id="33554059"/>
    <dbReference type="InParanoid" id="A0A1Y1UQK6"/>
    <dbReference type="OrthoDB" id="2564331at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18964">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="129" mass="14996" checksum="46B4A91F1C7FA1DB" modified="2017-08-30" version="1">MYQTRLCIKVDDKACSRHTNMCRARQRVITTEDDANVFLVEKIIGRKAISRNKDGTRNFVSLVKWLNYPVEDSTWEPKENIEPHTEALLARYEKERVEQNLSRAAKVVILKEYADHFDMDGNPLVKSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQL1</accession>
    <name>A0A1Y1UQL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_617369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874118.1">
        <property type="nucleotide sequence ID" value="XM_022014917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQL1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQL1"/>
    <dbReference type="GeneID" id="33556725"/>
    <dbReference type="InParanoid" id="A0A1Y1UQL1"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="700" mass="79919" checksum="64C47AD7E5364A9E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQP2</accession>
    <name>A0A1Y1UQP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative mitochondrial ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_615379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873672.1">
        <property type="nucleotide sequence ID" value="XM_022014714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQP2"/>
    <dbReference type="FunCoup" id="A0A1Y1UQP2">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQP2"/>
    <dbReference type="GeneID" id="33556522"/>
    <dbReference type="InParanoid" id="A0A1Y1UQP2"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="143" mass="16140" checksum="45B6CC0954E89530" modified="2017-08-30" version="1">MSYRQGQTALALHRVWHHASADGRVLGKFAARIALVLMGKHKPTYDPGVDAGDYVVVSDALKVALTGNKPTDKVYYHHSGYPGGLKTVPITRMRERRPEDIIRKAVSGMLPKNTFRKRRLERLRVYPGAAPQQDLDNIIKTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URJ4</accession>
    <name>A0A1Y1URJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_616266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873889.1">
        <property type="nucleotide sequence ID" value="XM_022014817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URJ4"/>
    <dbReference type="GeneID" id="33556625"/>
    <dbReference type="InParanoid" id="A0A1Y1URJ4"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="676"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="826" mass="92973" checksum="C657D13D51DCD23C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URN8</accession>
    <name>A0A1Y1URN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_616239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873881.1">
        <property type="nucleotide sequence ID" value="XM_022014811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URN8"/>
    <dbReference type="STRING" id="4999.A0A1Y1URN8"/>
    <dbReference type="GeneID" id="33556619"/>
    <dbReference type="InParanoid" id="A0A1Y1URN8"/>
    <dbReference type="OrthoDB" id="2587928at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012349927" description="Right handed beta helix domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="4">
        <location>
            <begin position="128"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="596" mass="65471" checksum="7EC4B4A3A3619509" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US19</accession>
    <name>A0A1Y1US19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_617203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874079.1">
        <property type="nucleotide sequence ID" value="XM_022014898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US19"/>
    <dbReference type="GeneID" id="33556706"/>
    <dbReference type="InParanoid" id="A0A1Y1US19"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="34688" checksum="9C1F0D9B5E8BD947" modified="2017-08-30" version="1">MENAHLPQLLSCYDPKSSHTCHRSLGRIQNLADEGKKRAGAGRWTPFVQKAPWYTFTFSLTLNWPRVEHSIKGEPSTERIDFKPCKLSHKPSLLTFDHNKQLASMSGSNQSAASTQAAMTSDFSLFTDDLVKQYAKDRALDPSVGTEPSLPGGPGLVLRIPISVVSDTLRNQPTQDGSRGVSYDNSTLKAIPEWKANMQTTAPGSYALPWIEVTGVALVIGKESQCPSTGCGKTANTIWAFSTGAEAPEGQQGKVVALESTCDTCPPPRDIRLTGPSTHMTKWRKPEGMTPVMLTQCSTDVDGKQCFYASEFDHEHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US37</accession>
    <name>A0A1Y1US37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_612065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874451.1">
        <property type="nucleotide sequence ID" value="XM_022014342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US37"/>
    <dbReference type="GeneID" id="33556150"/>
    <dbReference type="InParanoid" id="A0A1Y1US37"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="71" mass="7589" checksum="7FC7D0A832ACE54A" modified="2017-08-30" version="1">MPQLQSLECTNPCRRCTMGQIFLDAGGSRATLKGVVTVRAATKEGGHAYSPLSSYHFNSDTGSDDTAQSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US55</accession>
    <name>A0A1Y1US55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rapamycin-insensitive companion of mTOR, middle domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_640637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874540.1">
        <property type="nucleotide sequence ID" value="XM_022017359.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1US55">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US55"/>
    <dbReference type="GeneID" id="33559168"/>
    <dbReference type="InParanoid" id="A0A1Y1US55"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="274"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="777"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1169"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1407" mass="157563" checksum="423FD8271347EBCA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US90</accession>
    <name>A0A1Y1US90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_26447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874570.1">
        <property type="nucleotide sequence ID" value="XM_022012321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US90"/>
    <dbReference type="STRING" id="4999.A0A1Y1US90"/>
    <dbReference type="GeneID" id="33554129"/>
    <dbReference type="InParanoid" id="A0A1Y1US90"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="4">
        <location>
            <begin position="265"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="390" mass="42090" checksum="9971CBB33AA021B4" modified="2017-08-30" version="1">MSARASGEYTRPDVKRRLLVIGTGGTIASEPSSNGYTPLRNDHFYRRIRQHPLLSDPSGTSTPTLFSSPVLPVAVGVNTRYPELITPPLGDNEERVSYEILDLDKQMDSSEMTPSEWNIIAGLVEENWTDYDGFIILSGTDTLAYTSSILSFLFTNIGKPILVTGAQIPLSQPRSDGWANLLDSIYVAGVMNFAGIGVVFHHQVFQGNRATKTSPNHFAAFQSPCVPPLVNLNVKITLGGSITPRSSTLPPRLINLVTSPTVLSCSIHPGITGALLSAQIEAVPTCKAVILSAYGSGNLPISEENGALAALEAAVKRDILVVVISQCAIPNVYPLYTQGRTLLSKGVLPGHDLTHEAAFAKLLWLVSRKDLSFRQRQELFEIPIAGEMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USM6</accession>
    <name>A0A1Y1USM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874641.1">
        <property type="nucleotide sequence ID" value="XM_022017732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USM6"/>
    <dbReference type="GeneID" id="33559541"/>
    <dbReference type="InParanoid" id="A0A1Y1USM6"/>
    <dbReference type="OrthoDB" id="3342934at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012056141" evidence="1">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="19413" checksum="1C945BF458E45EF3" modified="2017-08-30" version="1">MLAHVLAFALVALFDPVASMPWRGHWQATTSTAVVQEGGVYDQAASTVPVVNPASSAPVDLGQGQIQVQASSVAQGVPLPSVSSGSAGGASGAGDIALVSTGTETHVVNLVNRCGQGTAVFQDVAGKTYTGSKTTYSGELISGLAWIKGAYGCGDKDGANCGDVEFTLKNGGIRVSITRSSRMVSRRIPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USR1</accession>
    <name>A0A1Y1USR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_641146</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874020.1">
        <property type="nucleotide sequence ID" value="XM_022017398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USR1"/>
    <dbReference type="FunCoup" id="A0A1Y1USR1">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USR1"/>
    <dbReference type="GeneID" id="33559207"/>
    <dbReference type="InParanoid" id="A0A1Y1USR1"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="19">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="18">
        <location>
            <begin position="195"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="337"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX40235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="397" mass="43804" checksum="09F074275D8B585E" modified="2017-08-30" version="1">MSDLQNPSSAQAGTSAETQPRQPLWLRCEKKPFEHRSALTPTTAKTLIDNNFEIFVERDPQRIFDDEEFEAVGCKMVPNNEWPSAPLEVPIIGLKELPLSTDPLPHTHIQFAHCYKHQGGWSDVLRRFAQGGGTLYDLEFLEDPQTKRRVAAFGFHAGFAGAAAGALAFAAQQQSGGQGKLAGLKPYANEAAMVKHVSEGLAGVEGGVENVKVLVIGAKGRCGSGAVDLFRKIGIKEDNIVKWDIEETSQKSGPYREILDVDIFVNCIYLSQPIPKFITSEFMAKESRRLAVVVDVSCDTTNPHNPIPIYDINTTFPEPTVEVDTQGVGKRCTVISIDHLPTLLPRESSEQFSKDLLPSLLQLPERASAPVWVNAEKLFRQKLEDARRDDEEKGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USX7</accession>
    <name>A0A1Y1USX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_6506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874215.1">
        <property type="nucleotide sequence ID" value="XM_022018174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USX7"/>
    <dbReference type="STRING" id="4999.A0A1Y1USX7"/>
    <dbReference type="GeneID" id="33559983"/>
    <dbReference type="InParanoid" id="A0A1Y1USX7"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="600" mass="67309" checksum="69939C8FBD9B73BC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USY3</accession>
    <name>A0A1Y1USY3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TAFII55 protein conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_613341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874808.1">
        <property type="nucleotide sequence ID" value="XM_022014487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USY3"/>
    <dbReference type="STRING" id="4999.A0A1Y1USY3"/>
    <dbReference type="GeneID" id="33556295"/>
    <dbReference type="InParanoid" id="A0A1Y1USY3"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="140"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="658"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="710" mass="75627" checksum="26D7D48C738E8128" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT56</accession>
    <name>A0A1Y1UT56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_647632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874393.1">
        <property type="nucleotide sequence ID" value="XM_022017690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT56"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT56"/>
    <dbReference type="GeneID" id="33559499"/>
    <dbReference type="InParanoid" id="A0A1Y1UT56"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012417710" description="alpha-1,2-Mannosidase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX40714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="524" mass="58468" checksum="BFBE9B08235A4B3F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT73</accession>
    <name>A0A1Y1UT73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_574831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874897.1">
        <property type="nucleotide sequence ID" value="XM_022013090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT73"/>
    <dbReference type="FunCoup" id="A0A1Y1UT73">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT73"/>
    <dbReference type="GeneID" id="33554898"/>
    <dbReference type="InParanoid" id="A0A1Y1UT73"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX41218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="113" mass="13088" checksum="58D512FBE3C5003D" modified="2017-08-30" version="1">MKVTILSYNSVAAWKWDTSTEPHKLCDYATNGDTDDYDDDDDECGICRLAYESCCPACKIPGDDCPLIWGECKHVFHMHCLLKWIDTESSKQQCPLDRRPWGKVDDWCFDCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT76</accession>
    <name>A0A1Y1UT76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_613419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874831.1">
        <property type="nucleotide sequence ID" value="XM_022014497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT76"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT76"/>
    <dbReference type="GeneID" id="33556305"/>
    <dbReference type="InParanoid" id="A0A1Y1UT76"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="862" mass="96833" checksum="AAC11D79E5F70889" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU73</accession>
    <name>A0A1Y1UU73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">BD324DRAFT_613562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU73"/>
    <dbReference type="STRING" id="4999.A0A1Y1UU73"/>
    <dbReference type="InParanoid" id="A0A1Y1UU73"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="268" mass="29575" checksum="14BF09BD9A680875" modified="2017-08-30" version="1">MLFIKTALIAVQGELMEFPRDRRPASPSADSVTSIESVGAANALSGLAPPREPTTVEGSESIINVSKQLGKEVRLKVDAGPGCGGIAWPSGEVLSQYIGYRYECDPSYLKGKKILELGSGTGLVGIAAGILEPTAEIWVTDQKQLLDLMERNVEYNGVSSNVHVDELNWGEQIPGHIPVNDLDMILAADCVYFEPAFPLLVQTLCDLIPIGKDIEMLFCWKKRRKADKRFFALLKKHFHSEHIEDARPGAKEQYSRDGVSLLQLRRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UV21</accession>
    <name>A0A1Y1UV21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Topoisomerase II-associated protein PAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_659627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874744.1">
        <property type="nucleotide sequence ID" value="XM_022018887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UV21"/>
    <dbReference type="FunCoup" id="A0A1Y1UV21">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UV21"/>
    <dbReference type="GeneID" id="33560696"/>
    <dbReference type="InParanoid" id="A0A1Y1UV21"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="343"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="832" mass="89601" checksum="0E6150144B97B1B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5K7</accession>
    <name>A0A1Y1U5K7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867630.1">
        <property type="nucleotide sequence ID" value="XM_022017335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5K7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5K7"/>
    <dbReference type="GeneID" id="33559144"/>
    <dbReference type="InParanoid" id="A0A1Y1U5K7"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="113"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="199" mass="21653" checksum="23C2697BCB32C110" modified="2017-08-30" version="1">MTDLRVGKDAQISSQSIARLTSQINIPCAQIVKMISPLPAPNRIVTGHADDGSSTITAEGPAQFSRLNTASLTQMSIAWDSLFPSPLSGEDTGKPGGGLPIYDSDKTRFWITDTPPHGQSPMHRTVSLDYGICIAGELTLLLDDGSERVLKPGDVVVQRGTMHQWFNRTDQWCRMAFICCGAKEPFVVNGSELKTEFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5V8</accession>
    <name>A0A1Y1U5V8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_279153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867756.1">
        <property type="nucleotide sequence ID" value="XM_022012364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5V8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5V8"/>
    <dbReference type="GeneID" id="33554172"/>
    <dbReference type="InParanoid" id="A0A1Y1U5V8"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="301" mass="32228" checksum="7E8759D750E29BBE" modified="2017-08-30" version="1">MKVFVTGATGRLGALVTQHLVERGHTVGGLVRSEASAAKIKGPSVEPIIGSLQDLELLTRMAQSHDAVINCAFDHSGDFDKASKEEAASAQAIIKGLEGSGKKFIFTSGFMIGQDWSSAERDETFMSNPSGLARTDTERMVLDSQKAGVTPIIMRLSAVTHTAKPPHWFLYAIHGISQSFGFLPYIGDGSQRWTTCNAEDASLLYALALETAEAGTHVHAVQETITVKDLVEAVGRKTGQKTGSITAEQAGPMGLVGMLMSVDQNISSKWTREHFGWTPKGQTLLEEIANAQEGFLSNGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U651</accession>
    <name>A0A1Y1U651_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maf1 regulator-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_275961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867825.1">
        <property type="nucleotide sequence ID" value="XM_022012353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U651"/>
    <dbReference type="STRING" id="4999.A0A1Y1U651"/>
    <dbReference type="GeneID" id="33554161"/>
    <dbReference type="InParanoid" id="A0A1Y1U651"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="531" mass="57368" checksum="04EAF207986BF7DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6E0</accession>
    <name>A0A1Y1U6E0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_654054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867918.1">
        <property type="nucleotide sequence ID" value="XM_022018744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6E0"/>
    <dbReference type="GeneID" id="33560553"/>
    <dbReference type="InParanoid" id="A0A1Y1U6E0"/>
    <dbReference type="OrthoDB" id="2592132at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="247" mass="26530" checksum="74EABA6E4957E839" modified="2017-08-30" version="1">MAGYVLGTGSGLLAAAAVYYTLSTSLRQATDSLQNDLHRSTALLSDSFDPQTPPAPSSYVGPSYPYTPRFTDTLRSRWNVAISRAFDGVRETDWAAMGLVVVDETGKVVKRLSTQLQNSETGQAVAKATPTSESVSRAADRVSEKAHRMVDDISSTAQKEASSVSHGLKSLWPKLTGAVQEVEKEAGVVSDEVKKLVHKGELEAQELDRLGAGVVGGNIREESFTGGTGRWVRAKRQVEGHLEGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U705</accession>
    <name>A0A1Y1U705_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_288649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000028">
        <property type="protein sequence ID" value="ORX33287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867642.1">
        <property type="nucleotide sequence ID" value="XM_022012386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U705"/>
    <dbReference type="GeneID" id="33554194"/>
    <dbReference type="InParanoid" id="A0A1Y1U705"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="539" mass="59086" checksum="71DE2860B05D5F59" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7E3</accession>
    <name>A0A1Y1U7E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_637771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868237.1">
        <property type="nucleotide sequence ID" value="XM_022017047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7E3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7E3"/>
    <dbReference type="GeneID" id="33558856"/>
    <dbReference type="InParanoid" id="A0A1Y1U7E3"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="459" mass="54234" checksum="BCD7790C960649E4" modified="2017-08-30" version="1">MRRLFPGSLLRQCRAPIGSRVLPPPPAVFVRAGSSKSVPLSNAKPRYDAEPDVATQRVTRTNDSLMRTTPHRVARRRKIWPVHRTRSERPLTDPDFRTEDSTEKRLPLRMETHFDNMRASGLLPGNDHQARRVYLEIMEDWRNRVRGHSSYFWDETKGRWTDESQEIFIWQRVKQRYPNLVYPKYDTPTSNIKELYLAGKAYPTLEEIDQTTLLYRYPHQDPTDRLSQLHSDMDVVDWDAVLKRIGTAQEDPQLWSKVKHTMTGYRIYLPNVQVVLRRNATPEDQPYDPMIATFRIPLSMTKTDLRSYLLACYGLEITFIRTDVRRGALTRSRDRRVVRQSGFRYNYKRAVVGLKEPFHYPDDIVELQSWGHQVGVGNLWKREAEEILEGTYGVESIKRERKEEAFRTFILHEDSTKYKSTKDVVLTPEQKLGRRVSRASRWRRRKKKMRTESLLIFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7E7</accession>
    <name>A0A1Y1U7E7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDP-alcohol phosphatidyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_639877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867799.1">
        <property type="nucleotide sequence ID" value="XM_022017293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7E7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7E7"/>
    <dbReference type="GeneID" id="33559102"/>
    <dbReference type="InParanoid" id="A0A1Y1U7E7"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000030">
        <property type="entry name" value="Cardiolipin synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="32301" checksum="C7A0F002538D1931" modified="2017-08-30" version="1">MLCPHCPPRRLLLLQELGRSLLARNPRPPPLPSSWKRQFHIARVQQTPRQIQRRLASRSVTKRIGQLCRAYGTVPESRKVEDPSQQPNEPELHESPYTLPNALTLARILACPWLGYEIIHEEYAWATGILFASGLSDWLDGYLARNWGGQSVLGSILDPAADKALMTTLVVTLAYSGLLPIPLAVLILGRDVALSISAFYFRFISLPRPRTLKRYFDPSIPSAEVKPTQISKINTALQLLLMGVTTVSPLIHLPLGTPLTLLQWTVAGTTIWSGFSYLGRSGVKILGKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7M0</accession>
    <name>A0A1Y1U7M0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_605407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868301.1">
        <property type="nucleotide sequence ID" value="XM_022014001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7M0"/>
    <dbReference type="FunCoup" id="A0A1Y1U7M0">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7M0"/>
    <dbReference type="GeneID" id="33555809"/>
    <dbReference type="InParanoid" id="A0A1Y1U7M0"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="137" mass="15467" checksum="3EA06A0389A2F6DD" modified="2017-08-30" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPQATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7U8</accession>
    <name>A0A1Y1U7U8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_636646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868387.1">
        <property type="nucleotide sequence ID" value="XM_022016918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7U8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7U8"/>
    <dbReference type="GeneID" id="33558727"/>
    <dbReference type="InParanoid" id="A0A1Y1U7U8"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="107" mass="11734" checksum="38276032D23AB1A1" modified="2017-08-30" version="1">MPAKKRCQYRVVYNIPAVPKPSSENTSDQPRSDAKPEMTANAPTQCPSAALKVIGECPHCHLAFCGTHRTPESHNCTGIQACREAAFQANKERLERERTVASKIAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U811</accession>
    <name>A0A1Y1U811_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_654290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000030">
        <property type="protein sequence ID" value="ORX33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867620.1">
        <property type="nucleotide sequence ID" value="XM_022018783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U811"/>
    <dbReference type="STRING" id="4999.A0A1Y1U811"/>
    <dbReference type="GeneID" id="33560592"/>
    <dbReference type="InParanoid" id="A0A1Y1U811"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="246"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="891" mass="98837" checksum="CD53E237D367B6A1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8B7</accession>
    <name>A0A1Y1U8B7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_584500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868055.1">
        <property type="nucleotide sequence ID" value="XM_022013684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8B7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8B7"/>
    <dbReference type="GeneID" id="33555492"/>
    <dbReference type="InParanoid" id="A0A1Y1U8B7"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="509" mass="55787" checksum="97A238B6547AA791" modified="2017-08-30" version="1">MILELSQSSKRVKRLWAKSQVRREPQHEREKLIRLCVAKASDYFTLMASGFALVSDGYQNNLPTIFNPIFTKLYGKEIYNSIVSTRVSNALLIGEIIGQLVVGLICDRVGRKTAMVGTTLMIVIGGILATAASGSTPAGMFWMLTVARGTVGVGVGGEYPACSTSASEAANEKFGRDRGKVFILLTNLMLSIGGPIVISLFLLIINGAHYKGTNDASDTHKLQYTWRILMGIGIIIPLSVFYFRLKMMNSKLYRRNALKKSTPVAIYGLVLKRYWKTLIGTAGTWFLYDFVTFPNGIFSSTIIAEVIPGAGLVRTLEWNLLFSILSLPGVFIGAFIVKYTGRRNLLIMGFSGYLIFGLIVGLAFDKIIKIHVLFIILYAFMQSSGNLGPGNMEGTISSESYPTSIRGTCYGISAALGKTGAAIGTQTFRPIQASLGKKYTFIIAACCGVVGVLLAFFFVEDKGKDRLEKEDEAWRQYLVEHGYGDLHMGDGSAADRSAADNREQEKLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9C1</accession>
    <name>A0A1Y1U9C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF962 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_123450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868873.1">
        <property type="nucleotide sequence ID" value="XM_022011965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9C1"/>
    <dbReference type="FunCoup" id="A0A1Y1U9C1">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="GeneID" id="33553773"/>
    <dbReference type="InParanoid" id="A0A1Y1U9C1"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25687" checksum="83BC553E18D887C6" modified="2017-08-30" version="1">MPTPHKLRSQGPAEDIDLDHPHGRDTEGSMFDIEYQMVQYGSYHHTTGNRLIHHVCVPAICWATLLMLAPLKVPGYSVTVLAKGFAFQPSFSLFLATFYQVFYFILEPTAAAAMMGLVALEYLTATYCYAFTPSWIPFQSSFNGSAVPFGVFVFVVGFLIQFVGHGVFEKRKPRLMDNLFQAFIAAPFFVWLELLFIFFNYRPELQAKLESKVETELRKLNSAKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9F3</accession>
    <name>A0A1Y1U9F3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_604971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868452.1">
        <property type="nucleotide sequence ID" value="XM_022013992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9F3"/>
    <dbReference type="GeneID" id="33555800"/>
    <dbReference type="InParanoid" id="A0A1Y1U9F3"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="899" mass="99210" checksum="6BAE2B5EF0BA3685" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9T0</accession>
    <name>A0A1Y1U9T0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_593880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869030.1">
        <property type="nucleotide sequence ID" value="XM_022013826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9T0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9T0"/>
    <dbReference type="GeneID" id="33555634"/>
    <dbReference type="InParanoid" id="A0A1Y1U9T0"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75712">
        <property type="entry name" value="Rad50 coiled-coil Zn hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="694"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="951"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117160" checksum="8DF6EA85FBE1B179" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9T6</accession>
    <name>A0A1Y1U9T6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydantoinase B/oxoprolinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_594682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868545.1">
        <property type="nucleotide sequence ID" value="XM_022013835.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U9T6">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9T6"/>
    <dbReference type="GeneID" id="33555643"/>
    <dbReference type="InParanoid" id="A0A1Y1U9T6"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="249"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="672"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="752"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1320" mass="143360" checksum="FDE637C0900142C3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9V2</accession>
    <name>A0A1Y1U9V2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_637400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868564.1">
        <property type="nucleotide sequence ID" value="XM_022017002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9V2"/>
    <dbReference type="FunCoup" id="A0A1Y1U9V2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9V2"/>
    <dbReference type="GeneID" id="33558811"/>
    <dbReference type="InParanoid" id="A0A1Y1U9V2"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="397" mass="43167" checksum="7EA35AF5BCA6419A" modified="2017-08-30" version="1">MMLITRGSTARALSRSIHQTKHVRSIHMLKDIPRPSSEDLQSRPRLLLSSSPSSQAESSSMAQRRFYPSHQLSKWSVDPRTILLIQKPRDERTAVAMGDLLRFLTSAFPHLRIIVEPHTAQDHPEFEDLIITAESDTALLPLHTDLVITLGGDGTILHTSNLFGDGACPPVISFSMGSLGFLLPFHINDMETVLQNALSGPVSVLQRMRLSCTPLDASGEILKCSMRVGESGWQVMNEVAIHRGRHPHLNVVDAYFDGEHLTEAVADGILLSTPTGSTAYSLSAGGPISHPDTDAFLLTPIAPRSLSFRTVILPGRGVVQLKISPLARSPAELSFDGREVCLLNPDESVIITKSPFPIPCIERGDGGAASGWVKDINSLLQFNTGFRNKSVMGHGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9V3</accession>
    <name>A0A1Y1U9V3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_605209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868602.1">
        <property type="nucleotide sequence ID" value="XM_022013996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9V3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9V3"/>
    <dbReference type="GeneID" id="33555804"/>
    <dbReference type="InParanoid" id="A0A1Y1U9V3"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF0">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="274"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="694"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="795" mass="88408" checksum="71B66B8613232E3C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ5</accession>
    <name>A0A1Y1UAJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ostalpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_646556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869255.1">
        <property type="nucleotide sequence ID" value="XM_022017629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAJ5"/>
    <dbReference type="GeneID" id="33559438"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ5"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="571" mass="63606" checksum="5327FEA4ABAE69A6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAU4</accession>
    <name>A0A1Y1UAU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_633955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869338.1">
        <property type="nucleotide sequence ID" value="XM_022016683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAU4"/>
    <dbReference type="FunCoup" id="A0A1Y1UAU4">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAU4"/>
    <dbReference type="GeneID" id="33558492"/>
    <dbReference type="InParanoid" id="A0A1Y1UAU4"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000015">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="13573" checksum="7982B80F809CE94A" modified="2017-08-30" version="1">MSWQAYVDDQLLSTGQISKAAILGKQGGIWAASKGYNLSQGEQNAITNTLFKKPDEARASGITLAGFKFMCIKAEPEEVIGRKGERGVFVVPTTQAVIVGEYEAPTQAGDANVVVTKLADYLKSVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB00</accession>
    <name>A0A1Y1UB00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_81552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869403.1">
        <property type="nucleotide sequence ID" value="XM_022019256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB00"/>
    <dbReference type="GeneID" id="33561065"/>
    <dbReference type="InParanoid" id="A0A1Y1UB00"/>
    <dbReference type="OrthoDB" id="3554264at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012914659" description="CHRD domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="69"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="223" mass="24820" checksum="610BDF62976E9BD3" modified="2017-08-30" version="1">MKFALVLVVCSTLVVAAPTWNDKQSWKDESRHHWEEKHKEWNDDHADWTGDHKSEHKDIHAAFPFEFTSILKAYAGPDQVVNNSQVAVPGLEKGFGMFQFGLNSHEDVICYNISVYIKGNYSSPAVTATHIHQAPKGRAGPPRIAFPNPQPHGNTSLDEYAWRYSLGCLQGPFKTGIVNNGTDTGAGFTVKDLEDTPWEFFADTHTADFPAGAIRGQIYGYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB24</accession>
    <name>A0A1Y1UB24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_604191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868959.1">
        <property type="nucleotide sequence ID" value="XM_022013975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB24"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB24"/>
    <dbReference type="GeneID" id="33555783"/>
    <dbReference type="InParanoid" id="A0A1Y1UB24"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="66"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="42884" checksum="4D17C5DA220E9825" modified="2017-08-30" version="1">MMAANKNGKRLVRRRSNVCNGTSTPIASASESSSASASASASASIWPTSAASESPSPSATNNNNGASASASPSPSASAGSSPWTLVDTWSGSNFFDNWNFWSWADPTHGDVDYVDVGTAWNNGLISINDQGDAIMRLETTNNLNRSRQSVRIHGNLVWTGGLVLMDARHMPYGCGTWPAWWQNGPNWPTGGEIDIIEGVNGFTQNQVSLHTAPGCYMPTDSNNFQKGTYTTGDYDSYDCSSADTANQGCGVRDQVDPNTYGQQFNTIGGGVYAMSWALDGINVWFFPRSQIPNDILNDAPLPSTWGTPMASFSSDSCSPYQYFYDHYNIFDTTLCGDWAGSDWVWQNAGYAGQDQSCAALTGYSNCVDYVRAQGSAFQDSFWQVSYVKYFNSTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB95</accession>
    <name>A0A1Y1UB95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_657323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869508.1">
        <property type="nucleotide sequence ID" value="XM_022018863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB95"/>
    <dbReference type="FunCoup" id="A0A1Y1UB95">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB95"/>
    <dbReference type="GeneID" id="33560672"/>
    <dbReference type="InParanoid" id="A0A1Y1UB95"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="13">
        <location>
            <begin position="98"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
        <location>
            <begin position="249"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="723" mass="80905" checksum="A35BB9DE67938308" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBD5</accession>
    <name>A0A1Y1UBD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_632301</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869502.1">
        <property type="nucleotide sequence ID" value="XM_022016506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBD5"/>
    <dbReference type="FunCoup" id="A0A1Y1UBD5">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBD5"/>
    <dbReference type="GeneID" id="33558315"/>
    <dbReference type="InParanoid" id="A0A1Y1UBD5"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="3"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="427" mass="47735" checksum="2BA0C7ABCE3C838A" modified="2017-08-30" version="1">MNYVQLEKLGEGTYATVYKGRSRTTSEIVALKEIHLDAEEGTPSTAIREISLMKELKHVNVVRLHDVIHTESKLVLIFEFCEQDLKRYMDTHGDRGALDLNTVKNFTHQLLTGIAYIHENRVLHRDLKPQNLLINRRGELKIGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDLWSVGCIFAEMITGYPLFRGKDNPDQLNAIMKVTGTPTAETLAQIKLNSPEIQMKNPLNKYPKQPLHALIPKAPRDAINLLEHLLQFEPTRRYDAHQAMAHPYFTSGPIAPPSIPASVSSSTASLALPPRVAQRASAASAAVQAQQQAAAAAAAQQQAAAQQAASQQQAQMMNQQQQQQQQQQQQQMMLMEQARQQQAQQGYYDPSQMQAQAQAQAAAQIQMAQAQARTMDPNGYYMNQDQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBF3</accession>
    <name>A0A1Y1UBF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_583206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869089.1">
        <property type="nucleotide sequence ID" value="XM_022013604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBF3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBF3"/>
    <dbReference type="GeneID" id="33555412"/>
    <dbReference type="InParanoid" id="A0A1Y1UBF3"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="525" mass="58068" checksum="AB4C04F45D03AA59" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBH5</accession>
    <name>A0A1Y1UBH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_593067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869583.1">
        <property type="nucleotide sequence ID" value="XM_022013820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBH5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBH5"/>
    <dbReference type="GeneID" id="33555628"/>
    <dbReference type="InParanoid" id="A0A1Y1UBH5"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="343" mass="36619" checksum="C93521205050447F" modified="2017-08-30" version="1">MTQSNGSSHAQPKWPNGPGVPLTTPFKPGNDEIDHEALASQVVRCAKAGLSIVLMGTTGEASMMSNAERKAAAATGRKALDEAGLKDAPLCVGTGGGSAQTTIELCKEAAEAGASHALVICPGYFAFAMGQQRQAILGFFKAVFDKSPIPVMIYNFPGAASGIDLTAEEICELAEHPNCFGVKLTCGNIGKGTRVALYTSSPEFLKRRGEVLKKHTETGQFQIGPGFVDTLLPALTARHTMCITSTGCLFPKTIRKLYLTAVKGLEGDMKSFQEARVLQDRLARADGISVATSFVGNKFFLDHYISKGLGGECRLPLAPITDATKKRVIEEFAEDWEFEQSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBK8</accession>
    <name>A0A1Y1UBK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_609674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869123.1">
        <property type="nucleotide sequence ID" value="XM_022014164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBK8"/>
    <dbReference type="GeneID" id="33555972"/>
    <dbReference type="InParanoid" id="A0A1Y1UBK8"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="493" mass="53674" checksum="A9C1A5AC45131D12" modified="2017-08-30" version="1">MGDYDGGGGGQARSVILLVGLSYYLIHKGELIRTIWLCGCLLDSFRALRTIRSNGRAVGLMTRRKAMREALRGWIVYILLGYSIPIVERLFSWIPLYGPLSTTLSLALVSTRSATSNMMYNSFIRGTVKKYEKPVDLTLSLIRSIWGLAALYLVEEPMMAARAVLGPLTGWSSTKAESRHVAQGDVNGDTVGSDGQALTGRIGQNLRINGSTFSHRTTDGPSGGHSDSLERHALGPRPEHSATQKSTISQLPPESLILPPSPDDLLEPTHQDTSVGTKLSSAVAPDLGPASDAHDLTKIAVRKHRPISTQTSTITGAEAPSEARLTVPMTNSHVERGLASSSSTRKLPRVLPRNIVRARTDLAQSDDKSARNMKALPLNRKLDHVTPKDITVVNTSRKTNTSGAPVNRPRQLSRVDQSRNSHPADPATSNLAHVSPRKRVRPRQDIYSGLESKRKRVEPDDVTNFAEKKASSKGNAAGQTDRLSKRVTVYKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBV4</accession>
    <name>A0A1Y1UBV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_633626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869233.1">
        <property type="nucleotide sequence ID" value="XM_022016637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBV4"/>
    <dbReference type="GeneID" id="33558446"/>
    <dbReference type="InParanoid" id="A0A1Y1UBV4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="170" mass="18562" checksum="EE2CBD852C901AC3" modified="2017-08-30" version="1" fragment="single">MCALHGWGIFAAHSSMYESGRGGQWYGSGYTNSSLAFRSVTVSVCLLLRFGSGIKPQRTPPDDGIDHEGRNSYGDGGSEFGAFFPPSSHLWWRGGGVKAAGSEGWGSAAADVPESTRSVHTRKRGEPALGIDHDPRGSWDRRFQVDSIMCRWYAMTDFAIQWQVTLSIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBX9</accession>
    <name>A0A1Y1UBX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_633498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869202.1">
        <property type="nucleotide sequence ID" value="XM_022016628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBX9"/>
    <dbReference type="FunCoup" id="A0A1Y1UBX9">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBX9"/>
    <dbReference type="GeneID" id="33558437"/>
    <dbReference type="InParanoid" id="A0A1Y1UBX9"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="554"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="626" mass="69178" checksum="E3F7D72711B11647" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCG1</accession>
    <name>A0A1Y1UCG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_74660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869902.1">
        <property type="nucleotide sequence ID" value="XM_022019234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCG1"/>
    <dbReference type="GeneID" id="33561043"/>
    <dbReference type="InParanoid" id="A0A1Y1UCG1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012101361" evidence="2">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="183" mass="20528" checksum="4096FFB96A14E1BC" modified="2017-08-30" version="1">MLLAICGILLSTAWIGVTTPPTIWRSDSMMHRSEDSLEAPNVLIHKAFHDDQCLINSHCFQARDESVWATNTRYTANVFTCVTCPTMIPTIPTMNQMMCTTLQVPVKSPRLPAILMIILLYGFLDLQHWTSYDHGQPGTSTTEIRTNESPKTHPSKPHLPGHNLPLDLASSRRHRLTTVPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCI2</accession>
    <name>A0A1Y1UCI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exonuclease 1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_652366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869414.1">
        <property type="nucleotide sequence ID" value="XM_022018476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCI2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCI2"/>
    <dbReference type="GeneID" id="33560285"/>
    <dbReference type="InParanoid" id="A0A1Y1UCI2"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0228">DNA excision</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="3">
        <location>
            <begin position="395"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="631" mass="69764" checksum="2262A8187DE252DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDC7</accession>
    <name>A0A1Y1UDC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative mitochondrial inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_581112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870187.1">
        <property type="nucleotide sequence ID" value="XM_022013484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDC7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDC7"/>
    <dbReference type="GeneID" id="33555292"/>
    <dbReference type="InParanoid" id="A0A1Y1UDC7"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000147">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial aspartate/glutamate transporter), member 12/13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="346"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="446"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="546"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="696" mass="76937" checksum="2BE7E30189B6FACA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDI2</accession>
    <name>A0A1Y1UDI2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase B complex non catalytic subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869740.1">
        <property type="nucleotide sequence ID" value="XM_022016358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDI2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDI2"/>
    <dbReference type="GeneID" id="33558167"/>
    <dbReference type="InParanoid" id="A0A1Y1UDI2"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="859" mass="96110" checksum="626D2CCA5880AC47" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE44</accession>
    <name>A0A1Y1UE44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CwfJ C-terminus 1-domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_632489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869535.1">
        <property type="nucleotide sequence ID" value="XM_022016522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE44"/>
    <dbReference type="FunCoup" id="A0A1Y1UE44">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE44"/>
    <dbReference type="GeneID" id="33558331"/>
    <dbReference type="InParanoid" id="A0A1Y1UE44"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="639"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="770"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="899" mass="101418" checksum="0EAC6CD1B6C75EB8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE97</accession>
    <name>A0A1Y1UE97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870482.1">
        <property type="nucleotide sequence ID" value="XM_022016129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE97"/>
    <dbReference type="GeneID" id="33557938"/>
    <dbReference type="InParanoid" id="A0A1Y1UE97"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="165" mass="17554" checksum="081C28A304CFCDC3" modified="2017-08-30" version="1">MTVTAPTTFTPSSPPDMASRHMDETPPPLVTPPAAAAAASNASKANTTVKRTMSSQSDGDRLTDENLQRQNKQISDANAEVDRETNAMPSIEQKKRTYSQDLYEYTKSLVDGVTKTGHSNGTSSTPSESNDDAHSLSLSTLSMKDQDDAAPAQASEEMAAVPAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UED2</accession>
    <name>A0A1Y1UED2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870521.1">
        <property type="nucleotide sequence ID" value="XM_022018369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UED2"/>
    <dbReference type="GeneID" id="33560178"/>
    <dbReference type="InParanoid" id="A0A1Y1UED2"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="20698" checksum="32BE6216EE2F33BD" modified="2017-08-30" version="1">MGSASSKAARRLPTTTPTAIRSVMPDLPSPAAEPLPSPSQPSETTARTRDDNVDMAGPSRLGPQVHSNEPFTGEKDDAIRRDALDPHFASNLSLLGPVYIKNSSEAVHSPALAQRTLAARRSQFHHLEGSPGPATLHASQLSDLLGALQAGHDKSDLCKHYGIDQAALDRLSRWTSVPLRVQSEYVQILRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEI9</accession>
    <name>A0A1Y1UEI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_628912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870564.1">
        <property type="nucleotide sequence ID" value="XM_022016156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEI9"/>
    <dbReference type="FunCoup" id="A0A1Y1UEI9">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEI9"/>
    <dbReference type="GeneID" id="33557965"/>
    <dbReference type="InParanoid" id="A0A1Y1UEI9"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001104">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.234, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="200"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="588"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="701" mass="77063" checksum="B40D0A317EDA732F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEM8</accession>
    <name>A0A1Y1UEM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_646091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870085.1">
        <property type="nucleotide sequence ID" value="XM_022017619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEM8"/>
    <dbReference type="FunCoup" id="A0A1Y1UEM8">
        <property type="interactions" value="661"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEM8"/>
    <dbReference type="GeneID" id="33559428"/>
    <dbReference type="InParanoid" id="A0A1Y1UEM8"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="550" mass="58596" checksum="EBDB70F21A7A9FBC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEP8</accession>
    <name>A0A1Y1UEP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_629074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870599.1">
        <property type="nucleotide sequence ID" value="XM_022016171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEP8"/>
    <dbReference type="FunCoup" id="A0A1Y1UEP8">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEP8"/>
    <dbReference type="GeneID" id="33557980"/>
    <dbReference type="InParanoid" id="A0A1Y1UEP8"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="202" mass="22537" checksum="C48F0D01BD2BA406" modified="2017-08-30" version="1">MTIFSLYIFDRHCDCIYYQDWNRTRPLRAPSTTNFKPGVHRLAPAQPSQTAGTRESIFSSGFSSGGIGTGITKAGNAMGSGAGASQRGLPFDEEAKLVYGVVLSLRNMVKKLSGRDEPLTSYSTPHYKLHLYETLTGYRFVLLSDPSSDSLRFVLRQLYTGAFLEYVVRNPLIDMDSRTEGIDNDQFRSAVDRHMKSLSVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF43</accession>
    <name>A0A1Y1UF43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_630304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870263.1">
        <property type="nucleotide sequence ID" value="XM_022016317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF43"/>
    <dbReference type="GeneID" id="33558126"/>
    <dbReference type="InParanoid" id="A0A1Y1UF43"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="94"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="686" mass="74460" checksum="85F58B9C3AA13793" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF47</accession>
    <name>A0A1Y1UF47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZPR1 zinc-finger domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_626796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870749.1">
        <property type="nucleotide sequence ID" value="XM_022015929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF47"/>
    <dbReference type="FunCoup" id="A0A1Y1UF47">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF47"/>
    <dbReference type="GeneID" id="33557738"/>
    <dbReference type="InParanoid" id="A0A1Y1UF47"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="56"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="331"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="546" mass="61013" checksum="C8F3522E71B122E2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF81</accession>
    <name>A0A1Y1UF81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_601370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870718.1">
        <property type="nucleotide sequence ID" value="XM_022013930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF81"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF81"/>
    <dbReference type="GeneID" id="33555738"/>
    <dbReference type="InParanoid" id="A0A1Y1UF81"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="438"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="636" mass="68923" checksum="472C32F89B48BC6B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFC8</accession>
    <name>A0A1Y1UFC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_651254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870839.1">
        <property type="nucleotide sequence ID" value="XM_022018300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFC8"/>
    <dbReference type="FunCoup" id="A0A1Y1UFC8">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFC8"/>
    <dbReference type="GeneID" id="33560109"/>
    <dbReference type="InParanoid" id="A0A1Y1UFC8"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="136" mass="15118" checksum="70230DADAFF053EA" modified="2017-08-30" version="1">MTVTSVVRDAVIAKRGSKTNESIVKTGRILLSTMAESDFVLLESEDGFTFSVPRKVACASNILKSMLDEEAAFSESTTNSCKIQYRGVIVLKIVEYLAYKVQYQDVNAEDITEDFSERIDPYIALELLTAADFLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL3</accession>
    <name>A0A1Y1UFL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_651314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870902.1">
        <property type="nucleotide sequence ID" value="XM_022018311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFL3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFL3"/>
    <dbReference type="GeneID" id="33560120"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL3"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="341"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="702" mass="76609" checksum="1E808D8326DF475A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFM8</accession>
    <name>A0A1Y1UFM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-mandelate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_642362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870868.1">
        <property type="nucleotide sequence ID" value="XM_022017482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFM8"/>
    <dbReference type="FunCoup" id="A0A1Y1UFM8">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFM8"/>
    <dbReference type="GeneID" id="33559291"/>
    <dbReference type="InParanoid" id="A0A1Y1UFM8"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="130"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="493" mass="54335" checksum="CCC7F1DBAB44FBA9" modified="2017-08-30" version="1">MAGGAALLYATEHEDPSAGPSRLRGDQRSISAFELGQHNRHDNLWVAIDGEVWDVTDFVQRHPGGSQILIDHAGKDVTKLFKGIHPAGTLEQNLREEQRMGRLDEDAIAKFRTMNGDEEDRIRKARDSLLGIDSIIVLDDFEKYARPVCPASAWDYYSTGVEGENSMKENSAIYDRVFFRPRVMRDVSDVDTSTKVLGVSSSIPLYVSPTARNGLVQPMGEVAVTKGAAAGGILQVLSHVASKSLEEVMKARSKGQQVAWQMYMKPDREVAAAEVRKAYELGAQSIWLTVDTVVLGKRTRERYTQVEKQPAPHGTKLTRVPCSREAQALTRHSRHDTNLTWEDIQMIKKNAPGLPVVLKGVGAWEDVVLAQQAGADAVVLSNHGGRQLDYANPPLKTLYDLNENAPQCLRRPDFQVFVDGGIRRGTDVLKALCLGANAVGLGRPFIYAAAGWGPDGVEKAIMILREELEISMRLLGVTNIDQLGPEYLNCSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG12</accession>
    <name>A0A1Y1UG12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_627841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871031.1">
        <property type="nucleotide sequence ID" value="XM_022016049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG12"/>
    <dbReference type="GeneID" id="33557858"/>
    <dbReference type="InParanoid" id="A0A1Y1UG12"/>
    <dbReference type="OrthoDB" id="2581368at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="281"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="596" mass="66303" checksum="0A55732DE051B5DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGE3</accession>
    <name>A0A1Y1UGE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870264.1">
        <property type="nucleotide sequence ID" value="XM_022016318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGE3"/>
    <dbReference type="GeneID" id="33558127"/>
    <dbReference type="InParanoid" id="A0A1Y1UGE3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="33461" checksum="C78CA7BD4AEBBD0A" modified="2017-08-30" version="1">MSSIPPFIKDSGSSFNYERQCDKGGSDKSLASCRILRKGLGTSIWFVQFYWPFGDERVTTTRIDLCNAWVTLYNERTRLWSIHEACVEVHQRKFWRKDCTSEQIDELKGMLAVASWLFHELDTFITLLDKFQSQTRIPVFLLPVPPHHSPLELGSSPYRTKPKTLSHELSTLPLLIVYQLDQIQSYTRRMPGWYEGVRKLFPPTWREGVGLPIIETNWSRWVKEQRRIEEESRRQPSSEQKKKSFLGIKFSKGSPSASSSSSSSSMPVQRASSPIGSIMERGKGKPPPYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGR6</accession>
    <name>A0A1Y1UGR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_579500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871197.1">
        <property type="nucleotide sequence ID" value="XM_022013383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGR6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGR6"/>
    <dbReference type="GeneID" id="33555191"/>
    <dbReference type="InParanoid" id="A0A1Y1UGR6"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="244"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="418"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="9">
        <location>
            <begin position="776"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="94056" checksum="FA54731F94608810" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH34</accession>
    <name>A0A1Y1UH34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_625715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871370.1">
        <property type="nucleotide sequence ID" value="XM_022015829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH34"/>
    <dbReference type="GeneID" id="33557638"/>
    <dbReference type="InParanoid" id="A0A1Y1UH34"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="53" mass="5869" checksum="C8258CC32311156A" modified="2017-08-30" version="1">MRLWVLDPSPPSSLVAFCSLLQDPPVLDILAFPCEREGRVMEGCTKGDPENTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH46</accession>
    <name>A0A1Y1UH46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUR7/PalI family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_473117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870916.1">
        <property type="nucleotide sequence ID" value="XM_022012882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH46"/>
    <dbReference type="GeneID" id="33554690"/>
    <dbReference type="InParanoid" id="A0A1Y1UH46"/>
    <dbReference type="OrthoDB" id="2559670at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23615" checksum="256995C8523F297E" modified="2017-08-30" version="1">MPVPDRTVGLPIHLLYPIISSVLLAVASFSSADSVWYVSANTPTETIRFAAQNYCGYNVSNLQITDKLGCIYRGWQYQIPDGYFGFDLPTDISKNFSKVVVTSVVAFALVVVAGVHHAYFIRYSFRKMPEPNKDKLWSLAQLHFVSIVVVFLFTWIAFIAQATIIGNSVGGDPQRSAVAIYWGQSTWLVLAAAILHTGWGYEAVRWRAAMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH70</accession>
    <name>A0A1Y1UH70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_627350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870905.1">
        <property type="nucleotide sequence ID" value="XM_022015990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH70"/>
    <dbReference type="FunCoup" id="A0A1Y1UH70">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH70"/>
    <dbReference type="GeneID" id="33557799"/>
    <dbReference type="InParanoid" id="A0A1Y1UH70"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="194"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="343" mass="37619" checksum="5FDACABE41D2064E" modified="2017-08-30" version="1">MGKERVAIIGSGNWGSAIARIAGQNAKIHADVFEERVPIWVFEEQVDGKKLTEIINTTHVNAKYLPGIKLPENVVAVPDVIESVKDATALVFVLPHQFLGGVLQSLEGKIEKGVKAISLIKGVDVEGSDIHIYADVIEKRLGVSCSALSGANIADEVAIDKFSETTVGYRKKEEGELWQRLFATPNFRVNIVADVAGVSLCGALKNIVAVAAGLVDGLEYGNNSKAAIMRIGLIEMKNFCLEFFDDVKVETFLEESAGVADLITSCLGGRNRKTAEAFVKTKKPFDQLEKEMLNGQKLQGIHTAKDVHNFLHSRNRIEGYPLFETIYQICWHDTPVDKLTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH73</accession>
    <name>A0A1Y1UH73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870903.1">
        <property type="nucleotide sequence ID" value="XM_022018312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH73"/>
    <dbReference type="GeneID" id="33560121"/>
    <dbReference type="InParanoid" id="A0A1Y1UH73"/>
    <dbReference type="OrthoDB" id="2594942at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="830" mass="90064" checksum="1BADC347A3B14918" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHE2</accession>
    <name>A0A1Y1UHE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ETC complex I subunit conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_626274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871490.1">
        <property type="nucleotide sequence ID" value="XM_022015877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHE2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHE2"/>
    <dbReference type="GeneID" id="33557686"/>
    <dbReference type="InParanoid" id="A0A1Y1UHE2"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="139" mass="15499" checksum="83A4C770561A743C" modified="2017-08-30" version="1">MFRASRVALAAAIKPMKASTGITGLHAVVDPLPTLKQHYQHTLNLLASLPNTSVYRQATEATTKHKMSIIDKANGDVKAVEKELGEMAEQSIQVAKDELKLAAKMLEWKPWEKLEEEAPPHQWRYFDPGSDEADVPSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHM0</accession>
    <name>A0A1Y1UHM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_384823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871547.1">
        <property type="nucleotide sequence ID" value="XM_022012639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHM0"/>
    <dbReference type="GeneID" id="33554447"/>
    <dbReference type="InParanoid" id="A0A1Y1UHM0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="223" mass="24612" checksum="E743065937F6D0AF" modified="2017-08-30" version="1">MPQRPRTDTGYSGNKGGLQEDQFPSGYDMEGDHRGNEGHARNRFETPRPRVHIAPRNLNIPPTIIEDRFSPLPLAQIPSDAVYAQQTYDPQPYEDPGNEYDKSVLPYSSSNPLSLRKPALDPDQYAFRSETPARRMIPRNRPSSVIPTSDARASVAPYPTALSKPGLAARMGIHTPVPRPGTAPGPRIFRKPTRHTKPAVYLTMIVLSFCLSSSSSSFNSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHM1</accession>
    <name>A0A1Y1UHM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">X-domain of DnaJ-containing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_626429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870654.1">
        <property type="nucleotide sequence ID" value="XM_022015894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHM1"/>
    <dbReference type="FunCoup" id="A0A1Y1UHM1">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHM1"/>
    <dbReference type="GeneID" id="33557703"/>
    <dbReference type="InParanoid" id="A0A1Y1UHM1"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="57913" checksum="AC8EC8DDB4336CD9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIL5</accession>
    <name>A0A1Y1UIL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_626012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871435.1">
        <property type="nucleotide sequence ID" value="XM_022015863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIL5"/>
    <dbReference type="FunCoup" id="A0A1Y1UIL5">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIL5"/>
    <dbReference type="GeneID" id="33557672"/>
    <dbReference type="InParanoid" id="A0A1Y1UIL5"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="287" mass="32869" checksum="93E28E16A0C83285" modified="2017-08-30" version="1">MITFRIKIGYPMLRMRAWRNSSISTLSSTHVMTILYHRLWLPIILAALVVRLWNAPQVLDLESLLQAGNGKEDHQERSVLVLTAHPDDEAMFFAPSILYLIESGWDVYGLCLSTGNATGLGEIRKRELVESYRILGVSADKVYHLDEPSLQDGMNIIWEPEAHILPYLQAHLEKQPVKHILTFDAYGVTQHPNHMNLPRAAQAIGPAVKVITLKSPSVLSKFTGVLWILYHKLFSRSDPDVAIVISSPRQWWAGIRGMLEHRSQLVWFRWLYLAFSRLMWVNELVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIP3</accession>
    <name>A0A1Y1UIP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871402.1">
        <property type="nucleotide sequence ID" value="XM_022015848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIP3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIP3"/>
    <dbReference type="GeneID" id="33557657"/>
    <dbReference type="InParanoid" id="A0A1Y1UIP3"/>
    <dbReference type="OrthoDB" id="6088208at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57398" checksum="EA08224CE7DF1A46" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJQ5</accession>
    <name>A0A1Y1UJQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871754.1">
        <property type="nucleotide sequence ID" value="XM_022018127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJQ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJQ5"/>
    <dbReference type="GeneID" id="33559936"/>
    <dbReference type="InParanoid" id="A0A1Y1UJQ5"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="117"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="32336" checksum="1174C5DEF4DF6CC5" modified="2017-08-30" version="1">MTAHLDLKPLTLNDIPDPESPEFAQFVDSYFAAGTKLADTIKSWTPHSSKKGVELSSLKSSNDQIRKALNISEFWCARTSYHTSESMKAMASGGKRIEEPNKGSNVNHGQTSAGTSVREVYERFRSGLFENHSEHERQYIEACQEAECLQVFKPQVAEVWRLTYSTPPPSSPRTFVALLLCRELDSTPGQRSFMNISVPFSHPSCVEKQGPEKSRARGRYVSVERVIELEQGGKVEWRMATSSDAGGNIPQFITNASLPSQIAIDVPSFIKWAMERFPDEAVTTTQANASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJQ8</accession>
    <name>A0A1Y1UJQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_620335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872222.1">
        <property type="nucleotide sequence ID" value="XM_022015270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJQ8"/>
    <dbReference type="FunCoup" id="A0A1Y1UJQ8">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="GeneID" id="33557078"/>
    <dbReference type="InParanoid" id="A0A1Y1UJQ8"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="323" mass="36228" checksum="67EEABEA363DBC0E" modified="2017-08-30" version="1">MDDTPDPLHQFFPETSSEDASSILYKTLNLPSTATAQDIRSAYRRLALRFHPDKQTSKSDKDKDELAKQFQQVGFAYAVLSDETRRKRYDTSGRTDENAFTDAEEMGWDAYFASLFQRIDRKMLDDDKAKYQGSDDEKVDVEEAYENSGGSLPNILASIPHSSHLDEQRLIDLINNLIDSGKLQSTKKWETTSKDKAARDKRKKKGEKEAKEAEKAARELGVWEEFYGSGEKGKRKGDSNVKQTAGEEGLAALIRKRQTDRAGGLDALAEKYARIEEEERAKKKAKKGGKASTSGTKEMTDEEFAALQAKMFGDKKGKKGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJT7</accession>
    <name>A0A1Y1UJT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_348944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872240.1">
        <property type="nucleotide sequence ID" value="XM_022012549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJT7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJT7"/>
    <dbReference type="GeneID" id="33554357"/>
    <dbReference type="InParanoid" id="A0A1Y1UJT7"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="75359" checksum="CE320B8983543E0E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK98</accession>
    <name>A0A1Y1UK98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator TACO1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872341.1">
        <property type="nucleotide sequence ID" value="XM_022015322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK98"/>
    <dbReference type="FunCoup" id="A0A1Y1UK98">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK98"/>
    <dbReference type="GeneID" id="33557130"/>
    <dbReference type="InParanoid" id="A0A1Y1UK98"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="2">
        <location>
            <begin position="128"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="300" mass="33371" checksum="35AC183936A27D1A" modified="2017-08-30" version="1">MTMTLRSHLMIWQCIQPVAGPSRTNLYASRTLLPIRTFVSTPVPNSGHNKWSKIKHKKGAADAAKSVLYGRIIRDLQNSLRPPNSLDPTINSRLADIMGKAKEVGMPKSVVERAISRAQSVLDGTGQSQTFEMMGPTSRDAYIVECLTDNPNRTIQSLRGIAKARQARITPVGFMFERKGSIIVQPATPQSDFDALFELVLEEGADDVKEVEGEESLEWEVVTPLELLSKITTSITSDPEKRFSVRSSDPAYIPLEYIEAPDEDAEPSDSDFDIEKASLFCSMLEEDQDVVRVWTNIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULG0</accession>
    <name>A0A1Y1ULG0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872299.1">
        <property type="nucleotide sequence ID" value="XM_022018039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULG0"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULG0"/>
    <dbReference type="GeneID" id="33559848"/>
    <dbReference type="InParanoid" id="A0A1Y1ULG0"/>
    <dbReference type="OrthoDB" id="3262547at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="454" mass="49525" checksum="EDB22F374487CF21" modified="2017-08-30" version="1">MPSLADSLAALSEHSKQISEACSHNTEPHGPFVQVQLYTSLFSLIRDASHKEVRLFKFVGEEGNGGRRIERRDGPLVTPLKKANKAEGVENLEAMLRAALKLVEDYGPMPRARSHIKDLIRTHDQHVDRMMELEELIELARQPRKVAPPPTSSPKGKAKVDIDEIIRAEEEALKALENSVASLRIQSRRSVSPEKVSPIAKAPRISVAVHTPGKTPTSSHQISNSLVSATPRRGAQPSRFSPLKLLTTPKVQKGRKSIFGRAGIRAPSGSAYTIPQIAPAVEEEEEGNETIRLASREEPPSPKPSPFKTPAKSSKVDYESQFVREGINKIQSTMPELLKDVDDPDAAIQQLGLLSESNPDAPPSPTSSASAPSQTTRLTPQTIMLAQFYLILLQSPDGTAVMNEVKEALTSIAQSRGWTDGPDLSTKVIYQSMAKKCTKIDRRGGNGGRISFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULL3</accession>
    <name>A0A1Y1ULL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_576995</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872803.1">
        <property type="nucleotide sequence ID" value="XM_022013230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULL3"/>
    <dbReference type="FunCoup" id="A0A1Y1ULL3">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULL3"/>
    <dbReference type="GeneID" id="33555038"/>
    <dbReference type="InParanoid" id="A0A1Y1ULL3"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="46"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="215"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="489"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="21">
        <location>
            <begin position="594"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="699"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1063"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX38940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131830" checksum="7A45C4B9FD2A87DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULP9</accession>
    <name>A0A1Y1ULP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase III RPC4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_650579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872032.1">
        <property type="nucleotide sequence ID" value="XM_022018171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULP9"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULP9"/>
    <dbReference type="GeneID" id="33559980"/>
    <dbReference type="InParanoid" id="A0A1Y1ULP9"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="525" mass="56623" checksum="57CA48E7B6081F41" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULU9</accession>
    <name>A0A1Y1ULU9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-3'-phosphate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_588837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872378.1">
        <property type="nucleotide sequence ID" value="XM_022013771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULU9"/>
    <dbReference type="FunCoup" id="A0A1Y1ULU9">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULU9"/>
    <dbReference type="GeneID" id="33555579"/>
    <dbReference type="InParanoid" id="A0A1Y1ULU9"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="198"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="376" mass="41143" checksum="635122D681A950C2" modified="2017-08-30" version="1">MAIQGEIFPDKGKGRSTSAAQEILRFSSHRFLRQRLVLCILSGRSIRVDNIRPDDVHVGLRDYEINLLRLVERITNGSTIDISVTGTSFVLHPGILPGGRHTHTCHLGRSIGYYLELLVPLAPFCKKPLTVTLHGITGSVNTDLTVDSIRTVTLPHLHMFGIEDMELKIIKRGSAPLGGGEITFSSPIVRHLKTIQVVDPGKIGKLRGIAYSTRVSPQFANRMVEAARGILNTFVPDTYLYTDVFKGEESGKSPGFGITLVAQSSTYTLHSAESSSATSRIPEEVGVRAARLLLKEVQSGGCVDSRHQWLVLLFMALGKEDVGKCLFGQLTSNTVQFMRDMQASLGVRFRITDAGSNLLLLSCLGVGYSNVNKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM53</accession>
    <name>A0A1Y1UM53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_679573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872935.1">
        <property type="nucleotide sequence ID" value="XM_022019048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM53"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM53"/>
    <dbReference type="GeneID" id="33560857"/>
    <dbReference type="InParanoid" id="A0A1Y1UM53"/>
    <dbReference type="OrthoDB" id="5964929at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="93283" checksum="B3E1F4BC820AFFBD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM55</accession>
    <name>A0A1Y1UM55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872994.1">
        <property type="nucleotide sequence ID" value="XM_022017954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM55"/>
    <dbReference type="GeneID" id="33559763"/>
    <dbReference type="InParanoid" id="A0A1Y1UM55"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="484" mass="52820" checksum="5D33D33E16911807" modified="2017-08-30" version="1">MNRDHLQVHLNAKSTTYALEASLPSCESGTPRTERNALASTFAVKPHAARIVVEGAPPIPTRRCRPLPPVPSDTPRPTLGRMPVWHGLHMTPYDGSRESAKRDFGSSLMQVPQSSPVDISLKTRLEFDLGQLFQRLECENRSIDSTSSALQLDLGPRCGAPEEEPPVQAPDAALGSDLSSPLTNDNVLRFDTIDAINCDEVESPLCALDIFSPRLPPAPVLRSLTDPHPISPLALPSTLGVDRKGERSYFTVTSSQDPTSSEGDNKVVSKAPLSSLGAPGLTANQSTLTTGSSWDLSSTQSSFSMGLGASMTSCSSRFLSLKERDHEAQSHTTLSEIVSRTQSATSQDELSTRRDWDDFGFPVPSRSFDALFEPSFRVRAGEQTKPVRDLLDKGDKAEEPWHSGYTSSELAFDIDGLPHISLPETLLEDPPDPPKTYQLLPRASIATDTYIEVGAWWNAAGLRGQNRSERRKSAMDYDSLLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM64</accession>
    <name>A0A1Y1UM64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_641679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872506.1">
        <property type="nucleotide sequence ID" value="XM_022017437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM64"/>
    <dbReference type="FunCoup" id="A0A1Y1UM64">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM64"/>
    <dbReference type="GeneID" id="33559246"/>
    <dbReference type="InParanoid" id="A0A1Y1UM64"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="41249" checksum="0ABEB7FBCF8E4095" modified="2017-08-30" version="1">MSFITAAAGPSRVTRAHTLVTFRRASHNQSGPKLAFAFDIDGVLKQGSHVLPQAKRALQRLSGVGPEISESGIVPFLLMTNGGGVTEAQRLASLSKDFEIDLAENQLVQSHTSLRDYVGKYRDEPVLVIGGVGDAGRRIAESYGLRQAYILQDLVAWRQSVWDRYVLTDEEKSFVKRDIDFSNVPLQAIFVIHDNGLDWALAIQVITELLTSDHGRMGTERYRDKGVSDGKEIHLVLTNPDIIWSNEYTLPRFGMGAFRLALEAVYKDKTGCPLPYEQFGKPHTATYEFAEKMLRRHLESRGEDPDQPLSVYMVGDNPESDIAGANAHGWSSMLVRTGVFRGGQPKYQPTQIVDDVEQAIDWAIERESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM69</accession>
    <name>A0A1Y1UM69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872962.1">
        <property type="nucleotide sequence ID" value="XM_022017947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM69"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM69"/>
    <dbReference type="GeneID" id="33559756"/>
    <dbReference type="InParanoid" id="A0A1Y1UM69"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="28372" checksum="EEEBB117DA2917BA" modified="2017-08-30" version="1">MVRRYMGQEPVPINGSDISEQLRGVMRNVPQPVALAVARTPSSAGEPSRYHGATLSSFTSLTLHPEPLVAFSLRLPSRLADFIRPGGKDIGHIPLYDPSSVSPSSATRSIPPQIPLPNNPPPHHSYASHSLTISLLAQCHAHLADRFARPGLDMSTAFSSTDFDLSKVPPGVKDALGILNCQVVMSLPLRDVSPPPSTGRMAETSPIDIQTGGDKVHGSELFICRVISVIQGDEGLVIDPLLYWRRKYISVQNQSEQPYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMB6</accession>
    <name>A0A1Y1UMB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_641698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872556.1">
        <property type="nucleotide sequence ID" value="XM_022017440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMB6"/>
    <dbReference type="FunCoup" id="A0A1Y1UMB6">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMB6"/>
    <dbReference type="GeneID" id="33559249"/>
    <dbReference type="InParanoid" id="A0A1Y1UMB6"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="322" mass="37200" checksum="DAE76049F754987E" modified="2017-08-30" version="1">MILLESHNVIVHDVLTDRFEKPSRADIQFVDYDNVRFHLSTPDSKTVLLLSMGIQCWPDLVKYGARDHLEKTFEGLLLSQGETEPEYDVSLRIDLEQIPQDPESRNALIDKIAHFKSTAMSAPFISAFEEQASLQANYKDAAGAQQMDVQPQEAKGDLKVVKYREEEAIFIQASHDRVTIIFSTVFKDETDRVYGRVFLQEFVDARKLGSLQNAPQVRYSNREPPLEIRHLPGLKNGEDWGYVTFVLFPRHFANPAQALATINRIQLFRDYLHYHIKCSKAYMHSRMRYRVAEFLKILNRAKPEVAVPQEKKTASGRTFRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMF6</accession>
    <name>A0A1Y1UMF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_375974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872596.1">
        <property type="nucleotide sequence ID" value="XM_022012620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMF6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMF6"/>
    <dbReference type="GeneID" id="33554428"/>
    <dbReference type="InParanoid" id="A0A1Y1UMF6"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="126" mass="13579" checksum="722224BAF4AA212B" modified="2017-08-30" version="1">MFSSYSSFCGLSVSESITVQLLGPTVTLFLGYLVLGETFERREVIAGFCCLIGTMFVSRPALLFESWSSGDTQAPSWGQSVPLDRSAGPGRTLGDRMVSVCWAVIAVFAASCGVCGTRQPIYCIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMH2</accession>
    <name>A0A1Y1UMH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase superfamily domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873121.1">
        <property type="nucleotide sequence ID" value="XM_022015114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMH2"/>
    <dbReference type="GeneID" id="33556922"/>
    <dbReference type="InParanoid" id="A0A1Y1UMH2"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF35">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="185"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="437" mass="49527" checksum="B800E3385175E02D" modified="2017-08-30" version="1">MPVGLRRIAIVLPLAYTGAWLGYYAYTDTLRRAHIRRRQREFNETIAGLPNGEIDYTKPATDIEKDALRKRFASLKFAGRYWNPYVEWREQGAWEWAFWKVILSTVTLKLFYNGGVPDERPIPDLPIERPDFAHLFGVSSGRSTPLSREEKGLGMTKSKVDLTDDLTITWLGQSTSYVTMDNLGILTDPALSDQPLNSMLAPHRLRPSPCTLDELQKVDVVLVSHNHFDHLDPEAIKTLGDSCEWIVPVGVGPFIRKHGVTRVKELDWWEETSHVLETKDKDICSFTITCVPLMHWSARSPLDTNATMWSGFHIRSHPPDNRPSRSFIHLGDTGHSPTLFSAIGRVLGPIDLAAIPIGAYEPRWHLHLQHTDPEGAVRMAMQLGVKKSIGVHWGTWLMSDEAYNQPPKDLEIAKRKLMFPVDRFIVTPAGRTVTIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMI3</accession>
    <name>A0A1Y1UMI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_649343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873123.1">
        <property type="nucleotide sequence ID" value="XM_022017975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMI3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMI3"/>
    <dbReference type="GeneID" id="33559784"/>
    <dbReference type="InParanoid" id="A0A1Y1UMI3"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33530" checksum="B80BAAD75C17038B" modified="2017-08-30" version="1">MATARLIESALYLSYRRITPRIVGPRPVLPPPQAGPSTRSLRLRPFSSSSPRHDQPKDDEIPYSEVHTVNDDGRLNGLVPLHRIRAAVNLQTHHVVLVSEDPPVVKVIAKTDLQAFERRREADLKTAKKLQIQEKEVQISWSAADGDIQTKLSQAKNHLAKGDRVLLIFAPRQGSKKRALPERMEHIVGLFDKGLEDTAEKWKDDEFKGRVVTSHWQPLKTVAAALKNKVLEQEDNKARSKDEKKEQRKREARARQELAMKRRREEEEETRRVLEARQRELDEIAAKEREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMM9</accession>
    <name>A0A1Y1UMM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873105.1">
        <property type="nucleotide sequence ID" value="XM_022015102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMM9"/>
    <dbReference type="GeneID" id="33556910"/>
    <dbReference type="InParanoid" id="A0A1Y1UMM9"/>
    <dbReference type="OrthoDB" id="2558924at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="235" mass="26492" checksum="10061C18593169E3" modified="2017-08-30" version="1">MSNPPKYETLHRDSLEETSLLSSDAAERGLSTSADPSLAYPPRHGESSTRKISVTYTFTPRYPVPGSEEHALAVLGETREESARICQRAFPTLADYPIDRIEFSVALKQTTDNGKPIGWGKITEDAWESLLYSPPERMMVRVIDAPGDAERRESCSTVSRECPLTPDRRQTRMQDMPLSLWPSHRSRPTVLWRVLSDQFCCQEMAGNGMMCLYDCPAYTDSIHTTHHRLVIVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMY6</accession>
    <name>A0A1Y1UMY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872707.1">
        <property type="nucleotide sequence ID" value="XM_022014931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMY6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMY6"/>
    <dbReference type="GeneID" id="33556739"/>
    <dbReference type="InParanoid" id="A0A1Y1UMY6"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="99"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="418" mass="46328" checksum="9E07DF40BF92869D" modified="2017-08-30" version="1">MTDQLPPISVGLMGTGEYTTGITPSGQSKSDKKIGVVGVTMFDLRRRGKVTDIIMAGTNGGKFPEIKQHFQKNIGDVYKGLDLSFRGFPEGNLRDAEAYKSALRALPKGSAVIIFTPDSTHFPIAAEALNLGHHVLVTKPATQKLEDHQKLIELAEEKGLVCFVEHHKRFDPAYNDARARAQKLGDFNFYCSYMSQPKFQLETFKSWAGIDSDISYYLNSHHIDIHCWMVEGRYKPTKVTASATTGIATSMGCDPKTEDTITLLVDWQNLEDSKQRGTAVYTASWAAPLKAGVHSEQRLHYMAAKGEIRVDQAHRGYSVVEDDIGKLDYNPFYVKYSPDENGFFDGQRGYGYLSLEKFIDAARSVSAGQSKASDYEGKGLPTVKAVVLTTAIIHAGRISLDEKRSVEIVDENGKWKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN04</accession>
    <name>A0A1Y1UN04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872727.1">
        <property type="nucleotide sequence ID" value="XM_022017912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN04"/>
    <dbReference type="GeneID" id="33559721"/>
    <dbReference type="InParanoid" id="A0A1Y1UN04"/>
    <dbReference type="OrthoDB" id="2564054at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010986956" evidence="2">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="163" mass="18142" checksum="671AFC00CDBC3273" modified="2017-08-30" version="1">MLPVPAASPLFLALFYSILFLATSPSSPFVDSPIPPALSSLSSSAPLPDRTWLSVNSGRVQDPHLAGYQPTYPFNETDPGSLLTSNDDQDPRTIDDEIPPNHVDWRYRGIGLIVDFGWKRSDAGIRWERGSVGLRKDTKEDRSFGFLTRFSRLLRRGVSHGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN25</accession>
    <name>A0A1Y1UN25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_649016</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872780.1">
        <property type="nucleotide sequence ID" value="XM_022017920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN25"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN25"/>
    <dbReference type="GeneID" id="33559729"/>
    <dbReference type="InParanoid" id="A0A1Y1UN25"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="231"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="419"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX38917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="623" mass="66827" checksum="D2673EE6F4C94843" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN45</accession>
    <name>A0A1Y1UN45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glicosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_617654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872739.1">
        <property type="nucleotide sequence ID" value="XM_022014943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN45"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN45"/>
    <dbReference type="GeneID" id="33556751"/>
    <dbReference type="InParanoid" id="A0A1Y1UN45"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="142"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="280"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="875" mass="98542" checksum="95BB7678E758545D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNF8</accession>
    <name>A0A1Y1UNF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_575957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873368.1">
        <property type="nucleotide sequence ID" value="XM_022013160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNF8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNF8"/>
    <dbReference type="GeneID" id="33554968"/>
    <dbReference type="InParanoid" id="A0A1Y1UNF8"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="40193" checksum="ACDF4CE31F99E7F6" modified="2017-08-30" version="1">MAYVNGYPTRSPNILQQSQQHSLHIPQPNHHSNLGSPAVSNSHTPEPQTNGGVKVQPLLCSGHTRPVVHLQFSNLLEDGTYLLISACKDGNPMLRSWLGDWIGTFLGHKGAVWSSKISLDTSRAVTGSADFSAKIWDCNSGEALHTFTHNHIVRSVALSPQPQPQYLLTGGNEKKIRLFDLGRPDAEPLILGSNPDGLSCDGTIRSLVWDEAQGGSVGVSAAEDGIVRWWDLRTLSQTGSLNLEDPITSMELAHGGGTLSVTAGNKVHFLDIMRQHPPVTVPLPHPPTSASLHPFLRDRFVAGSANDPWVRVYDLDSGQEKEVYKGHHGPVLCASYSPDGEVYASGSEDGTIRLWQTNPGKSYGLWQTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNG2</accession>
    <name>A0A1Y1UNG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_618273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872887.1">
        <property type="nucleotide sequence ID" value="XM_022015008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNG2"/>
    <dbReference type="FunCoup" id="A0A1Y1UNG2">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNG2"/>
    <dbReference type="GeneID" id="33556816"/>
    <dbReference type="InParanoid" id="A0A1Y1UNG2"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="316" mass="35097" checksum="15E5B8F6F4840AAC" modified="2017-08-30" version="1">MLYIIGLGLSDEKDITVKGLEAVKRCERVYLESYTSILMIPKEKLEAFYGREVITATRETVELESDDILRDADKVDVAFLVVGDPLGATTHSDLILRASDLNIPTTVIHNASILTALGATGLQMYNFGQTISLPFYTETWTPESWYDRLEENLQVGMHTLVLVDIKVREQSEENMARGRLIYEPPRFMSPHTAFKQILLTETSRNPPTGTTSSSEVTEDETSTAPRSTTLLPPDQTLALSLSRIGTSTQRIIAGTLSELAALPEEEFGPPLHSVVIVGKRLHPLELEFAGRWCVGGENGAWWKVGKDVYGVEKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNI6</accession>
    <name>A0A1Y1UNI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_641302</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872917.1">
        <property type="nucleotide sequence ID" value="XM_022017415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNI6"/>
    <dbReference type="FunCoup" id="A0A1Y1UNI6">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNI6"/>
    <dbReference type="GeneID" id="33559224"/>
    <dbReference type="InParanoid" id="A0A1Y1UNI6"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="74"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX39054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="380" mass="42455" checksum="CD098CBAB4C52342" modified="2017-08-30" version="1">MTIAKKEEVTGASGSKFTLKDLIGMGGGDGAPKLGRKTSAAGSQKGSDRGSTRGSERDYGDNTSTASLLKKYGICDKAAIGKGATAVVRLAHKWDRREEKLYAVKEFRKRRKNETEKDYVKKLTSEFCISSTLHHINVVETVDLVQDEAHHWCEVMEYCPGGDLYAAIKKGGMSSGEVECSFKQILLGIQYLHSMGVAHRDIKPENLLLDGRGHVKITDFGVSDVFRMCWEKKTHFSKGLCGSEPYIAPELFEQKEYDARLVDVWAAAVVFYCMQFQELPWRVAKSTDPTYKDYVTAYSPTKPLAEGQHHPTPPPLNNLVPRECRLLIKHMLDPDPKTRWGIDDVLKDKWMQGVEVCEEGKENSHSHSSAGMDIVKIVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNS1</accession>
    <name>A0A1Y1UNS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UV radiation resistance protein and autophagy-related subunit 14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_614626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873476.1">
        <property type="nucleotide sequence ID" value="XM_022014621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNS1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNS1"/>
    <dbReference type="GeneID" id="33556429"/>
    <dbReference type="InParanoid" id="A0A1Y1UNS1"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="90942" checksum="DFC44BA6342F5440" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNZ4</accession>
    <name>A0A1Y1UNZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_614915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873553.1">
        <property type="nucleotide sequence ID" value="XM_022014663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNZ4"/>
    <dbReference type="FunCoup" id="A0A1Y1UNZ4">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNZ4"/>
    <dbReference type="GeneID" id="33556471"/>
    <dbReference type="InParanoid" id="A0A1Y1UNZ4"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="80"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="397" mass="44676" checksum="01E5AD4982DE62D4" modified="2017-08-30" version="1">MSALQSALRILTRPCSSSFASLLLRRSANASRRPFASVGESQHNEQERKPQLLAPRGFVSESTDPWFNLSYEDWLLRNTPHDEPTLFVYRNKPCVVIGRNQNPWKESTPQWLREQDIPLIRRRSGGGTVFHDLGNVNFSIMLPRLLFTRNQGAELVAKAVRDRLGISSCTVNDRNDVIIRTTERDLKVSGSAYKIIQHRAYHHGTMLISSDLSNLGQALRSNSPQMETKGIPSFRSPVTTLNSHLSSGQHPITPEDFITAVTQEFSAVYTGSEESMVVQQVSEDQMNEPNVLRGVEELKSWDWTYGQTPEFTNLIESHIGDNQLTAKIASRKALITDIALTWSEATGSADRVLRQVEERLLGAHYESLLIDSDWSSLESSNDRQLAEQILASLREAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP79</accession>
    <name>A0A1Y1UP79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_238502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873623.1">
        <property type="nucleotide sequence ID" value="XM_022012252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP79"/>
    <dbReference type="GeneID" id="33554060"/>
    <dbReference type="InParanoid" id="A0A1Y1UP79"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="509" mass="55487" checksum="6AA15A5E751A2E24" modified="2017-08-30" version="1">MNLVWSIRFDFGALAPSSNRTFGQSSQTLKDVSGPPPGLLPSIREHTPFDMVLQNLATMAQTECLDGCLRHVSSSPFPLDNHIVQASGNNSGTNTTHQDLIDLFASPEPPPGHKTTNETHWAVDPSPYSLSQLTPTKLHQNMSSDHEDPNLISPRGVEYSPRYLDSYSSPCVASKNNSLHVEEEPYVPPSARLTAIHTMLDKHATSPETRMETAISKMLGIQTTALEEKLGLIVQNQARQQEQLDLLIQTVARIRGLSNQVECLNQTHAEQTPRLENMELPGLDEPLFEKSLEHSVSRSDLLSVVRKDSENSPLQSCIDPKAIEEKHRFVSDSLPDIEDRVTAGSSAKVTTEIEPDERGAAAANNETQSRRLAMAPPARLNSPCNTFTPRSLHASSTRSYTISSRAGSIFSAVSRSQRMSTRSSIGAAKERSQQGAGGDTHISHKASKITAKPSQTAETTHSAKRRRTLAPKLKLNGRRLAESDGKARGQGIWPKKGTNTAVGTLVGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQR1</accession>
    <name>A0A1Y1UQR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_607080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873692.1">
        <property type="nucleotide sequence ID" value="XM_022014046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQR1"/>
    <dbReference type="GeneID" id="33555854"/>
    <dbReference type="InParanoid" id="A0A1Y1UQR1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="226" mass="24484" checksum="FA79DB3F1C458C1B" modified="2017-08-30" version="1">MTNGNNAAKRMPSAALGGRQSRRLQMRNQPVPVSVAGERGAGERWGGTTFCCGSANYSDRRCGTRSIDECGREDGREEDSGERLPPESVDFGSNIDNVKRKYKPNGSVVVGMVEHRGSSRCERCQLDDLPCFQREGKATMKCKSCTSDHCSFHSGHAGSPLTRASGSAQIPKASSKALVHLEQSDSEDDIEQLEESDDEDQGSGKKRKRGRIFDTGSQPVSSLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQY6</accession>
    <name>A0A1Y1UQY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_576051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873679.1">
        <property type="nucleotide sequence ID" value="XM_022013170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQY6"/>
    <dbReference type="FunCoup" id="A0A1Y1UQY6">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQY6"/>
    <dbReference type="GeneID" id="33554978"/>
    <dbReference type="InParanoid" id="A0A1Y1UQY6"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="136"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="576" mass="64573" checksum="24B22A50D876CB36" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR31</accession>
    <name>A0A1Y1UR31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatase phospho-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_647465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874217.1">
        <property type="nucleotide sequence ID" value="XM_022017664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR31"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR31"/>
    <dbReference type="GeneID" id="33559473"/>
    <dbReference type="InParanoid" id="A0A1Y1UR31"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="246" mass="28074" checksum="5B9BDF2A42CC5B5F" modified="2017-08-30" version="1">MGKTLVVFDFDWSFVDQDTDRWVFEVLSTKLRRLLETRKSAGSQCTPDVVNDTMGDLAEEGFTKDQVLDALRILPFHPAMRRAVLGLRERNPNVEYLCLSNSNEVYISTILERHGLTDLFSNIITNPASWNSSNSNRLDIGRRVPANGPQHDCKVGCLANMCKGEELEAYISERGGRSSYEKIVYIGDGGNDFCPLLRMKEGDWALVRKNMELDARIKNEGEKEGLKVEVKKWSQAWQIDEYFQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URG9</accession>
    <name>A0A1Y1URG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874337.1">
        <property type="nucleotide sequence ID" value="XM_022017684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URG9"/>
    <dbReference type="GeneID" id="33559493"/>
    <dbReference type="InParanoid" id="A0A1Y1URG9"/>
    <dbReference type="OrthoDB" id="3365874at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19381" checksum="2AB39AD2E31FDFC4" modified="2017-08-30" version="1">MARGRAIDLKLPPTRARTQQRDYRARKAAHTRDLEEENARLRHVNAVLQDEASQLRSMYANFVSALEESQRDLMNAQRRLDAARDALTQLGTRYPPYTNYSSADTLVHTSHTNVTPSSHVTSPNSPWSSVRMAPTIDHPVDTPNPRSECQPGKLESPPDPSEECCFGLVVCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URZ6</accession>
    <name>A0A1Y1URZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_245855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873740.1">
        <property type="nucleotide sequence ID" value="XM_022012268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URZ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1URZ6"/>
    <dbReference type="GeneID" id="33554076"/>
    <dbReference type="InParanoid" id="A0A1Y1URZ6"/>
    <dbReference type="OrthoDB" id="2564849at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="295" mass="32752" checksum="89B8956DE0EB6E33" modified="2017-08-30" version="1">MSLHRYVVPPPLALAIEPAPPPKPHKDHKPDSKDSKDPQKDDKPAAAGKAGGTNDEDKHKNQIAEAGVKAGDIDKEEKPKAPLQTPTPEDSPVVPPSPGSMIPEPGTPRLGAEPPKDVAPVPGPREAVKPAGQQEMPKDRLSEEVKSPTTEDQQEVEQHIKVEPLWLLTPAPHRPLRTRLQLNPDKPYPPINTDPRGAYFKYARGVQAEWILIDVTKDGWLVDQWREKPEREALARLKGEADKQRDREVEALERRSKIRQVPKTSEEILLHLWNDLAEAPSYEVGSPAGEQVTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USG2</accession>
    <name>A0A1Y1USG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_616419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873910.1">
        <property type="nucleotide sequence ID" value="XM_022014827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USG2"/>
    <dbReference type="GeneID" id="33556635"/>
    <dbReference type="InParanoid" id="A0A1Y1USG2"/>
    <dbReference type="OrthoDB" id="2562097at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="357" mass="38352" checksum="EF9E95063AD7D889" modified="2017-08-30" version="1">MMTPAASRVAPTLRLNLVHTRNLHRQAISVRPTRSTVIRPAQFRSYAEGANSGASNNTQMFVILGAIAALGGGIYYMVKPISDAAYAAKGAVKTVQDTAGSAGDATSVIARAVLPPSALAVYDKLASQPGGLNGLLSSLKDKDLQGVIDEVKKIGGDDVKRVVEKVEAKVKDAKGNVQNVDWKALAKELKKELPKEQQNLVDLLIGYVPDKSDIDGMINKVKSEAADQLKQLEAASNKIWKEVEKAKKEGKGQADALIKGFKSATPDDLDDLVKQLKEAAKKAGLPADQIESWLKSKADEKNIDPEQLSKQLQSKLKTAEKFLPGQPKDLVKQVDQISPSAAKLLQQAMEQAGIMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USG3</accession>
    <name>A0A1Y1USG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_616494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873920.1">
        <property type="nucleotide sequence ID" value="XM_022014831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USG3"/>
    <dbReference type="FunCoup" id="A0A1Y1USG3">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USG3"/>
    <dbReference type="GeneID" id="33556639"/>
    <dbReference type="InParanoid" id="A0A1Y1USG3"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="328" mass="36667" checksum="11F53DD74D034D85" modified="2017-08-30" version="1">MPHSHHSHSGQFCRHAKDNLEQIVQEAISQGFELYGLSEHVPRCRTEDLYPEESGLTPEDLDQTFASFLREATALKGTYAAQITLLTGMESEHITSLDLEKVQSLIEDPRIDYIVGSVHHVHGIPIDFDKATWQRAISESYKRTHGTPLYQEDQTPASGAQVALFLPFLHAYFDAQFQMLQGLQPEVVGHFDLCSLYTPGISLCSLEPALRSKIERNVRYVTDYGGLFEANSAALRKGWTSSYPSEDVLGLIVSHGGKICLSDDSHGVAQVGLNYALMREYLVSKGVDTIWHLVSVDRAEHGDERVGNRGRVLARPVPGWQMGSFWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USK1</accession>
    <name>A0A1Y1USK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DExH-box splicing factor binding site-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_647882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874660.1">
        <property type="nucleotide sequence ID" value="XM_022017734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USK1"/>
    <dbReference type="FunCoup" id="A0A1Y1USK1">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USK1"/>
    <dbReference type="GeneID" id="33559543"/>
    <dbReference type="InParanoid" id="A0A1Y1USK1"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="5">
        <location>
            <begin position="216"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="460" mass="53567" checksum="C9384EE47928D124" modified="2017-08-30" version="1">MSGPISFTVKPPSAPHRPSPLGNGGYRSGPPSRRMFESGHDDEDNEDERSHHRREGRREERVEGFRNGRSHGEPKDEPLVIPSLPNRDWRQTVQRRTPSFRPEERKQDGEMITHERTGDGPQRSGIRIPVRTEMQTNGESSTTPTAVSAADESDAGSVVRSEPLSLEQQALAEILAGGHHTETEEERAQRELVIAMSEGKDMTEEEAYRRDVDTLPEESTLEDYAAIPVSAFGLAMVRGMGYDPKSEKGTVVHEPKIRPQLLGLGATPMDPSIRPTHSKHGSKSAKERQEERRTKTGRGFNAANLLVKQEREGSSSSITPSGSTLASPNGSERRRRREEGDRDYDTGREVKRERNDEDQASSRDRDRDRDRRHQRVYETEEERSERKARERRDRDRDREYETDEERAARRARERRERDRDYETEEERMRRKERERRDRDRYDDRERDRYRDDRDRRRDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USN2</accession>
    <name>A0A1Y1USN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_6416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874213.1">
        <property type="nucleotide sequence ID" value="XM_022017431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USN2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USN2"/>
    <dbReference type="GeneID" id="33559240"/>
    <dbReference type="InParanoid" id="A0A1Y1USN2"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="92" mass="10374" checksum="3121F47AB9F1A742" modified="2017-08-30" version="1">MTPVAVTTTTTTTSHPTPNGSVEVSKTVDVIVKDNKGKRVPNQRFERIKAQNVTYHHDGLKDNSFDARVSMESFMEDHGLMLPLDRRWSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USP7</accession>
    <name>A0A1Y1USP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_267175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874010.1">
        <property type="nucleotide sequence ID" value="XM_022012328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USP7"/>
    <dbReference type="STRING" id="4999.A0A1Y1USP7"/>
    <dbReference type="GeneID" id="33554136"/>
    <dbReference type="InParanoid" id="A0A1Y1USP7"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="651" mass="67796" checksum="2ABB98E610D9AB9F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USR6</accession>
    <name>A0A1Y1USR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_617052</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874030.1">
        <property type="nucleotide sequence ID" value="XM_022014873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USR6"/>
    <dbReference type="FunCoup" id="A0A1Y1USR6">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USR6"/>
    <dbReference type="GeneID" id="33556681"/>
    <dbReference type="InParanoid" id="A0A1Y1USR6"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="437"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="689"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1025"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1037"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX40245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116845" checksum="71ABE2652CBF68C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USU5</accession>
    <name>A0A1Y1USU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rds1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_678481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874767.1">
        <property type="nucleotide sequence ID" value="XM_022018997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USU5"/>
    <dbReference type="STRING" id="4999.A0A1Y1USU5"/>
    <dbReference type="GeneID" id="33560806"/>
    <dbReference type="InParanoid" id="A0A1Y1USU5"/>
    <dbReference type="OrthoDB" id="2098436at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012282227" description="Rds1 protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40108" checksum="EB78656EDCF874ED" modified="2017-08-30" version="1">MVFLTQAIAVLLAASKVQFVSAAPAPVPSGGVGVRSNDTPPVYGVMSDFDYQSFLLALNQEWIELDLFNYGKSRFSAEEFASAGLNADDVSLIQFKADQEVGHADLLSNIISIGGRTPAVQCKYKYDFDTVPDFVNFCQRLTRWGESGVYGFLSHLDSRPAAALLTQSIATEARQQMVFRQFSGAHPMPVFFETGISQSMAWSLLSRYLVECPAQNPKIEWQIFPWLSVTNESNLLQDGYLAAITHNRTSLSEPGRNITFRWDDTNQTVSYNNSYTTSIGGAINSSAPAFVAFVSQLNVTYAPLTVTGSNTGYAAQPGGVVFNNTLDPVINGTTFVALTDVDLYVTPYNLSLLNDHIFAWGLYQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE1</accession>
    <name>A0A1Y1UTE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_21317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874473.1">
        <property type="nucleotide sequence ID" value="XM_022012191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTE1"/>
    <dbReference type="GeneID" id="33553999"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="312" mass="32816" checksum="120F0D3E377959A4" modified="2017-08-30" version="1">MLGTSTRPTTPGTDDMFRSYPETPFTYKSPENSMRMGNNPSTDYLLARGEGSDIANAGFGFGGYPAPGYNRGGGDGEAYGRQQRFNQGLGMGLRSQSQESVTGVPLLQHAPQPDGEPRRARSRQGSTSTVGAPYPPTAYTQPVPHGYTPPGAPRQRSGSDLSYNGGGGSAGAPHQPQPWESNSDLSRSRQPSIGYGLPPGATMTGYNDSFAPSHVPRQGSASSQGQGQNRQSPPVQMDRYGSPGPILRHESPVSYSTPPPGSQDPRSQHPQGMRQPSASGPGGGMRPGGPRGPSGGGPPNQGRYEDPYGRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTQ2</accession>
    <name>A0A1Y1UTQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sucrase/ferredoxin-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_647808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874583.1">
        <property type="nucleotide sequence ID" value="XM_022017720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTQ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTQ2"/>
    <dbReference type="GeneID" id="33559529"/>
    <dbReference type="InParanoid" id="A0A1Y1UTQ2"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="393" mass="43218" checksum="BF407B43CA09A269" modified="2017-08-30" version="1">MQWIAKRSVLLQPGIRTFQLQRFYSTSAQDDPWPLPLPRSLAARQGLFLLALPAPPSAWPAKLEFASPLLSAASQVFKRNGLAVNAYYDGSGAAEHLPIEEETYPARLLFPDGRTFEYPEFRLDSLQDHNVMRDANYKPDPVKALATSSGRNVTGLQEIFVCTHGARDCRCSDRGGSLVAALRKEIERKGAVDAVAVREIAHVGGHKYAANAILAPSLDMLSNLTAEHAPALLSHIMTGRPLRSSLWKHWRGRYGLTEEQQGELWHQVDPGEAQTVSNAAGSSVRIRFETFEGDIKEVNARLGDSLLQIGKENGLPSLEGVCGGNLECATCHLYLPPTGSPPPVPEPSEEELDMLGYAIDYRDGQSRLGCQVKVTQELVKWIEDGGIIKLPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTT3</accession>
    <name>A0A1Y1UTT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_647528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874284.1">
        <property type="nucleotide sequence ID" value="XM_022017676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTT3"/>
    <dbReference type="FunCoup" id="A0A1Y1UTT3">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTT3"/>
    <dbReference type="GeneID" id="33559485"/>
    <dbReference type="InParanoid" id="A0A1Y1UTT3"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="268" mass="29474" checksum="D17A722D0079AA20" modified="2017-08-30" version="1">MVQNNQDLKRADVWFICHGVRIGPPTMFDFEGEGYKSWVKMGESVRASNPKGIVIVSAHWESDYTSDQGIVVSINSELDNPLIYDFYNFPKHFYEERFCSQSDPAIRKAVKDALTSEGVLIKEEKRGIDHGVWPPLKVVLGEKTTVPILQVSLPGDSSPVSTAKVGKALSAIRDQGYTVIGSGQTVHNLRDYFSGRPTPYTEPFLAAASAAVHSSDPVGQSIGLTKHPLYRSAHPTDEHFLPLVFAVAAADPGDKQHGRDKDTFALHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUG4</accession>
    <name>A0A1Y1UUG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_38881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874785.1">
        <property type="nucleotide sequence ID" value="XM_022012655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUG4"/>
    <dbReference type="FunCoup" id="A0A1Y1UUG4">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUG4"/>
    <dbReference type="GeneID" id="33554463"/>
    <dbReference type="InParanoid" id="A0A1Y1UUG4"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14280">
        <property type="entry name" value="UBA1_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="424" mass="43693" checksum="E13FA5095B3DFD9F" modified="2017-08-30" version="1">MVKITFKTVQNKLFTVEAEGSETVADVKRKIQDTQSFPSEHQKLIYSGKILNDAATVGSLNIKEKDFIVVMVSKPKATPAVAAAASSSTPASAPPAAPAMSTETTSTPSAAPSSTENSASVTAAGSTATAPDASNAPESTQAVPASATTGSTSSGHGLDGGSFVTGPALQQAIEGMVEMGFPRDQVQKALRASFNNPDRAVEYLMSGEMPTGEDEGPASLPTAPIPAAPSTATPSAPIQPSTQAPAVAPTSDAPTSRAQGSAENLFAAAEAAMNRDRGVPTPAAGAGAAGAGRGGQSEAMAAFANSPILQQLRQMVRENPAMIQPLLQRLMSSSPQIAQYINQNPQALYDFLGIDAGDDGDGDDDMLGQQTTQINLTQEEAAAVERLEALGFDRAMVLQAYMACDKNEELAANFLFENGDEDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUT7</accession>
    <name>A0A1Y1UUT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874915.1">
        <property type="nucleotide sequence ID" value="XM_022017783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUT7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUT7"/>
    <dbReference type="GeneID" id="33559592"/>
    <dbReference type="InParanoid" id="A0A1Y1UUT7"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="529" mass="58646" checksum="88D00DBA16BA5595" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5H3</accession>
    <name>A0A1Y1U5H3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_640344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Cytoplasmic vesicle</location>
            <location evidence="9 10">COPI-coated vesicle membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Golgi apparatus membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867637.1">
        <property type="nucleotide sequence ID" value="XM_022017340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5H3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5H3"/>
    <dbReference type="GeneID" id="33559149"/>
    <dbReference type="InParanoid" id="A0A1Y1U5H3"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000020">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="276"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="488" mass="53200" checksum="9A71E4331D08DB72" modified="2017-08-30" version="1">MVVLAASICTRSGKPLLSRQFRPMPRSRVDGLLASFPKLIPVNSQHTTVETADVRFVYQPFEELYVLLITNKASNIVQDLSTLNLLVRLISSLTPAMSEPAILHHSFDLLCAFDEVVSLGYKENVSLTTVRNILEGESHEEKIQEIIARNKEAEAKEELKRRAKQLEMQRREQQKRAVGGGGFGSSMGSGMAGGYQSAPRFEAPAMPEYRTPSPAPALSKPAFKGSGMKLGKKGKQSELSSLLSGEPEPEPEPEVHAAPEPEPVAVSADVLEKVDQESIHLTIKEQLSVTLLRDGGVKSFELKGDLDLRIAEPSLAKLRLTLAPNDYSELQFKQHPNVAKFSGSEKIIALKDANRSFPVGQGLGVLRWRMSAKDESNVPLSITCWPQPRGDGTSDVAIEYELEATHLTLRNVVISIPIPTDSLPSVTGDADWRAERNAFVWTIDTVDSENPSGSLEFKCDGDADAFFPVSVGFVAAGSLANLEVSQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U642</accession>
    <name>A0A1Y1U642_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_275984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867826.1">
        <property type="nucleotide sequence ID" value="XM_022012354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U642"/>
    <dbReference type="GeneID" id="33554162"/>
    <dbReference type="InParanoid" id="A0A1Y1U642"/>
    <dbReference type="OrthoDB" id="2596228at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="285" mass="31912" checksum="FE2EC6A03E53F57D" modified="2017-08-30" version="1">MSGSRLRTRYEAQMSDVVSAAGEMELMGETSINELRSPVNRTFAIDEEEEDEDVMGFEARERGRLFGEGDEEVLADGYMSNEDEEEEDDGDEEMLMGDGEGEEDDEDEEEEEEEEEEEEEGEDSEELGFGSETSSMVYDRNVDPVGWAKRLDELAGVMEMGEEEVRALKWGPVMGNGAPVPLLPLEDFKTVLNHHLTTTEWKYTSSPDLFPPIPSRQPLDTMTHLGLPLDLDSAVHPIRVLGRDWVGRRAERPIFDNVHEGDDDSEFGHDTFGLTGLGLSVDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U666</accession>
    <name>A0A1Y1U666_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_610594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867819.1">
        <property type="nucleotide sequence ID" value="XM_022014205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U666"/>
    <dbReference type="STRING" id="4999.A0A1Y1U666"/>
    <dbReference type="GeneID" id="33556013"/>
    <dbReference type="InParanoid" id="A0A1Y1U666"/>
    <dbReference type="OrthoDB" id="2596929at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="712" mass="75258" checksum="3197B62C3575FAA4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6A3</accession>
    <name>A0A1Y1U6A3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867867.1">
        <property type="nucleotide sequence ID" value="XM_022017210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6A3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6A3"/>
    <dbReference type="GeneID" id="33559019"/>
    <dbReference type="InParanoid" id="A0A1Y1U6A3"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="2">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="52704" checksum="ADB248436491835B" modified="2017-08-30" version="1">MQQARDFGVRLLVFHLGNTGQVDAEEHERVVAATAKRIRKLLKKVPEVDLAVETMTDRCCGETSHSLDAIQRFITLVNMPGRVKFCMDLCHVYMQFDLAETEARGEFLRAVEGLGREAIAAVHLSDSLEKHGTRKDSHTNLDFGYIGSDAFREILRHPSFSRVPIILETPGYFCGNRDRDQGVPAQIGCLERARHELEIQLINRITDATDEEWAADWISIRKNHRKEKAQIETKIRNLVMRTGGTLRDTLLANRAAVNGKLCAVGRHWAREGKGLSGSGRRHKKPRRSSQRAAHLSDPISSIRETRAMTVSSRRRQELRERKEARANAAQRPSFREESWVRGSSLFSDHSPEPDPWTFEGSKARKRNKRPKAGSTGMNWPRRVDIRDSPASASGGCPVELSPVNLGHPSLYDTLNGDRQPSPGPSRLRRELPGEEERLGSDATAIEEHVSECKAQKLRRRKDKGKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6V5</accession>
    <name>A0A1Y1U6V5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_638479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868060.1">
        <property type="nucleotide sequence ID" value="XM_022017120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6V5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6V5"/>
    <dbReference type="GeneID" id="33558929"/>
    <dbReference type="InParanoid" id="A0A1Y1U6V5"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="297" mass="33145" checksum="7DEB895B642A1D80" modified="2017-08-30" version="1">MTRGKVNRQTGLSDDQLYSLLSRPSAVSDINTISTFLSSPCHDLPLEDSVDTVFVLLGSSVLPLFAAVAQSILTRHGKTTLVISGGRGHSTQYLYDAVAGHPVYHTLADKIQGLSEAEVIQTLLLGFWPDLRLKLESDQLRLMIEDRSTNCGSNAMETKRVLQEAGISPERIHIIQDPTMHRRTLLCFMKAYGIDPTTAKNQRPDLRGWTFEPTIAASVTGVPRWDIQMNRLGGIERHDLWNYARFFSLIMGEIPRLRDDGDGYGPRGAGFIPHEDIPHDVESAWRRLNDEIAAIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6W1</accession>
    <name>A0A1Y1U6W1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_638558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868082.1">
        <property type="nucleotide sequence ID" value="XM_022017128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6W1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6W1"/>
    <dbReference type="GeneID" id="33558937"/>
    <dbReference type="InParanoid" id="A0A1Y1U6W1"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="79224" checksum="F10B0E47FBF02E44" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6X1</accession>
    <name>A0A1Y1U6X1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="15" type="ORF">BD324DRAFT_638604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6X1"/>
    <dbReference type="FunCoup" id="A0A1Y1U6X1">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6X1"/>
    <dbReference type="InParanoid" id="A0A1Y1U6X1"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="456" mass="51849" checksum="00BB553953B20B6F" modified="2017-08-30" version="1">MPRGWIQRLWLGGTLTLISWISFSCQIGIIWPWYGSVLSLDLLKLLVPFNLLVFMVFWNYRLCVTTPPGEVPRGWRPSLSNMEGVEVKKNSHAPRYCKMCNHYKPPRTHHCRQCKTCVLKLDHHCPWIVNCVGYYNQGHFIRFLVYVDLATSYHLAMLVRRVMDMTPRYAAEPTLFDILFLVFNFATCVPVWLCVGMFSMYHLYLVSGNSTTIEGWEKDKVATLVRRGKIREIKYPYNIGFIANMNSVLGSNPLLWLWPQAMKGDGLSFPVNPEAGDSDAQYQWPPQDPTRLPNPPPRSGQSAFTYGGESFNPALKPSSSSSSALEQIGIGELRNRRFSSTLSEGSEGSEASGSSPEHYLSDYDYDESLENGDKAVEEARRMQQPYPSDNNVRVRRGSEGYEVSSGAAAWNMDLEHQVAAHSAWDQPRGPVWLEQGRYNVYEPHAVDDDDDYDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U754</accession>
    <name>A0A1Y1U754_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868159.1">
        <property type="nucleotide sequence ID" value="XM_022018723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U754"/>
    <dbReference type="GeneID" id="33560532"/>
    <dbReference type="InParanoid" id="A0A1Y1U754"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="608" mass="67815" checksum="1D4AF720837AF4EF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7P9</accession>
    <name>A0A1Y1U7P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyhypusine synthase</fullName>
            <ecNumber evidence="7">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_638102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868320.1">
        <property type="nucleotide sequence ID" value="XM_022017084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7P9"/>
    <dbReference type="FunCoup" id="A0A1Y1U7P9">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7P9"/>
    <dbReference type="GeneID" id="33558893"/>
    <dbReference type="InParanoid" id="A0A1Y1U7P9"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003052">
        <property type="entry name" value="PRK03971.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="348" mass="38137" checksum="46913985AF52E048" modified="2017-08-30" version="1">MSEAGPSNTNAHASVLTPSEAIPPNAVHIHGPDLSDPIDLVDLLKSYEKIGFQATGLARAIQIVEKMRVQRSNAEEPLTLFLGYTSNLISSGLREVIKFLAKYKLVDCIVTTAGGIEEDFVKCLGPTVLGDFELDGASLRKRGLNRIGNLLVPNSNYCKFEDWILPILDKMVEEQEGEPKAKWSPSSVIRRLGKEIDNEDSVYYWCYKNDIPVFCPALTDGSLGDMIYFHTYKASTPLSIDIVQDIRLLNDMSIHAKKAGMIILGGGVSKHQIANAMLFRNGADYAVYINTGQEYDGSDSGARPDEAISWGKIRAGAESVKVYADATLVFPLIVAATFAKARWSTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Z9</accession>
    <name>A0A1Y1U7Z9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear fragile X mental retardation-interacting protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_636891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868437.1">
        <property type="nucleotide sequence ID" value="XM_022016946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Z9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Z9"/>
    <dbReference type="GeneID" id="33558755"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Z9"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="507" mass="54875" checksum="30CBB1178068CB49" modified="2017-08-30" version="1">MAYNPSYWNANGRPAQSWYGQSSQPGPSSQPYGYPASVQPVNLSGGYNPYAGYAPQATWGAPSPSFGQTLFRGGSSAYSHPSANPDPSRPAKRPKGQDQEDTPSHSRGVSAWRNCSVPGCGFVGPGDQVEIHEGDRHLIFPNGHRVERSEEEEKFAKRRGPAPVIEGTTITLQTDEDIAKWIAERKAKWPSARRVAEKEEERRSAIERGELPARGRGRGGRDARGGRGGRRNDPASQAEDWGRPVTPLDGVSERGPRGRGRGRGRGTPRGRDAGYGARGGAHGGSDRIVQHETSPARAPSHEPGPQGDMSARVEAQNAVKNTIGGLAAYDSASDEDEDASDDSSSTTLSDSEPTTSSDESDEEVEPAKANDSSQLRTIPAIADKPLCKFFAKTGKCRHGDRCRFAHVREVNQQNRNQAERHRPVAKRQNPFDRPGMLSALLATPIQNTLSQISQTIRFLVANDMLENVELKPGDAEALARRHDLITEVSPKSETFALDVPEAGQADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U820</accession>
    <name>A0A1Y1U820_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rossman fold oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_666222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867957.1">
        <property type="nucleotide sequence ID" value="XM_022018914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U820"/>
    <dbReference type="GeneID" id="33560723"/>
    <dbReference type="InParanoid" id="A0A1Y1U820"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29645" checksum="550FEB90053701BC" modified="2017-08-30" version="1">MSTAVIQGSSGGLGFALTQHVLKHTSLNVFALTHRSAKELQERLGHHERLTVLDRVDIRDEGTLEKAASTVRERQGNDSVRLIACFAGVLEPEKSLRMINPQTLLDTFQINCMGHLLTYKHFVPLIPSKKAFAELKWDEDPAKGLVAKTNSLCFSLSARVGSIEDNKKGGWYSYRASKAALNQFIRTLDHELVNKSSSGVAMAYHPGTVLTSFTRPILGAKAEPNPDKGQFSTDQAVEHLVSIMSKASREQEWGGRLWDYKGEQIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U840</accession>
    <name>A0A1Y1U840_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative B-type regulatory subunit of protein phosphatase 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_653965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867977.1">
        <property type="nucleotide sequence ID" value="XM_022018731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U840"/>
    <dbReference type="FunCoup" id="A0A1Y1U840">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U840"/>
    <dbReference type="GeneID" id="33560540"/>
    <dbReference type="InParanoid" id="A0A1Y1U840"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="728" mass="81621" checksum="087DA221C8CD045E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8D2</accession>
    <name>A0A1Y1U8D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_653541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868550.1">
        <property type="nucleotide sequence ID" value="XM_022018670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8D2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8D2"/>
    <dbReference type="GeneID" id="33560479"/>
    <dbReference type="InParanoid" id="A0A1Y1U8D2"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="6">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="166" mass="17605" checksum="E0566B4B9E34CC3F" modified="2017-08-30" version="1">MIVRTAANIGPSRVLYGVRTIASSSTSSTVASSSSSPAASTSRQSSPPRQSSSSSLKSPTAQSQSPPKTHHFVKLVRSTIGLQQVYKDTVRSLGLKRRHSVALVPFNKGFGGMLIKVKELIEVRNVTKQEGLDLLRRTKDRSEGAGVVPTGLAFGGSRSKSVEGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8E5</accession>
    <name>A0A1Y1U8E5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868566.1">
        <property type="nucleotide sequence ID" value="XM_022017003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8E5"/>
    <dbReference type="FunCoup" id="A0A1Y1U8E5">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8E5"/>
    <dbReference type="GeneID" id="33558812"/>
    <dbReference type="InParanoid" id="A0A1Y1U8E5"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="74"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="180" mass="20024" checksum="76A9B1B8D0150543" modified="2017-08-30" version="1">MSTMRAASQALRATVSSARQASSRSYILPAARPTTALQSRPAPVLGIRFKSTSSDWAKKPTITYDELKPITRQPTDDVLIIDVREPDEVMLGSIPSSVNLPMSEIQQALQKNYDASDFKRKFFFSKPLPGQNIVFYCRSGKRAGTAAEIAAENGYKNVRNYVGSWQDWSKREGLEGEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8W5</accession>
    <name>A0A1Y1U8W5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_637726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868215.1">
        <property type="nucleotide sequence ID" value="XM_022017037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8W5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8W5"/>
    <dbReference type="GeneID" id="33558846"/>
    <dbReference type="InParanoid" id="A0A1Y1U8W5"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="317" mass="34183" checksum="B2B61AD189032B36" modified="2017-08-30" version="1">MARSRSPSGSRSRSPVKRRAGSADVETAGDIEASGCPFLIRLFLSKGRHAPMIDFDDGKFPIRDEFQVYGWKTSTPTSLIALVYANLPPPYRSPLARFSFRHIYVDASARGLYKSNDLVSFTGRDLSATLEEKPESKGMDMELDQTIDSGGPGARRGRKVDEKTLDGYGFVTGDLLSVCVNVPEPKLHPGPNRPPLMGLSNGAGAGGPGDRIGGGFGRPDKFNGREGGREVHPSDKEGTWSRGEALPPAGRPIRGSAGRELLGERSGAGPRPSNGLGIRGAGTRHRSGSPPDGRDNGYRRRSRSPADRNRRESYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9J1</accession>
    <name>A0A1Y1U9J1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_634526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868941.1">
        <property type="nucleotide sequence ID" value="XM_022016741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9J1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9J1"/>
    <dbReference type="GeneID" id="33558550"/>
    <dbReference type="InParanoid" id="A0A1Y1U9J1"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="29716" checksum="D3AFE3C7A44A6424" modified="2017-08-30" version="1">MKLKRSGKAGISWPIQERSSDPVLEFFPQNSNLSWHYNWNKNYDSLLPETKPGLTIDAEFVPMIFAPDYLDNGVELQDGHRLVLGFNEPDHHDASVAVQTSVETAVEAWIRLARDRKPGVKLASPAVAHDIQWLETFFKLIPPDTKPDYLAIHVYTTTFVNLQERVEVYWKTFHLPIIITEFAMTSFSGAPPPRDVQQVHDFMGQATKWLDETVYIYRYAWFGACRNPANLHGVHPLNRLMDDDGRLTPLGHQYVSCGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9S7</accession>
    <name>A0A1Y1U9S7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative shk1 kinase-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_583708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868544.1">
        <property type="nucleotide sequence ID" value="XM_022013633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9S7"/>
    <dbReference type="FunCoup" id="A0A1Y1U9S7">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9S7"/>
    <dbReference type="GeneID" id="33555441"/>
    <dbReference type="InParanoid" id="A0A1Y1U9S7"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000020">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="40"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="442"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="605"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="476"/>
            <end position="477"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="557"/>
            <end position="558"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="6">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="872" mass="93061" checksum="63A1482068A8992D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Y3</accession>
    <name>A0A1Y1U9Y3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_604389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869080.1">
        <property type="nucleotide sequence ID" value="XM_022013981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Y3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Y3"/>
    <dbReference type="GeneID" id="33555789"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Y3"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="511" mass="57926" checksum="192896957B97D0FB" modified="2017-08-30" version="1">MTSAPLPRTFIDFEVGGEPKGRVVFELFADRVPKTAENFRALCTGEKGISPISNVPLHYKNSIVHRVIDEFMIQAGDFTKRNGSGGESIYGGMFADERLEGEGCQVDKAGLLVMANRGPNTNGSQWFVTLAPAPHLTGKHVVFGRVIHGFEIIEAIGKLATDDRDRPLSPVTIIHCGELELRKAPAKKLRTTSPTSSVERSPPRRRAASRSVSPPRRAIRSPQSDGERRERAHIDSEEDSEREERRRRRERKRREKEDRRESRKERKRAGREETEAELDARLEREEKEQLEKARLAKLEAMKKQIEEDRQRAQDSGEVVYKGRGAMRYLDPESAMAKRMPTNYDSRTPDIRARHPPRGFGGPRGGVNGSGPGEGGRWERGMDVRPNFAAEGERFRRGSERGDRASERDRQDRELDRYKVKGRSGTGDDIGREGRKRDWDDWRSGRGAMYGEGRRVDEQRRSSRSRTRSRSASPRRASLDHRSPSPKMRAESPLRGDKSDASGSDMVMEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA01</accession>
    <name>A0A1Y1UA01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_643341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869095.1">
        <property type="nucleotide sequence ID" value="XM_022017538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA01"/>
    <dbReference type="GeneID" id="33559347"/>
    <dbReference type="InParanoid" id="A0A1Y1UA01"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013322231" evidence="8">
        <location>
            <begin position="33"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="519" mass="56541" checksum="354056E1CFD17D62" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA74</accession>
    <name>A0A1Y1UA74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD324DRAFT_610040</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 25">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868680.1">
        <property type="nucleotide sequence ID" value="XM_022014183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA74"/>
    <dbReference type="FunCoup" id="A0A1Y1UA74">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA74"/>
    <dbReference type="GeneID" id="33555991"/>
    <dbReference type="InParanoid" id="A0A1Y1UA74"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="21">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="22">
        <location>
            <begin position="289"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="85"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="477"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="495"/>
            <end position="497"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="518"/>
            <end position="521"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="680"/>
            <end position="681"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="690"/>
            <end position="694"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORX34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="767" mass="85056" checksum="8E0A5F62FB99689A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ1</accession>
    <name>A0A1Y1UAJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_683537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868373.1">
        <property type="nucleotide sequence ID" value="XM_022019191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ1"/>
    <dbReference type="GeneID" id="33561000"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ1"/>
    <dbReference type="OrthoDB" id="2575973at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013095909" description="Hydrophobic surface binding protein A-domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="20510" checksum="9B476EF3857FED19" modified="2017-08-30" version="1">MLFAKYLLAALPLVGSAFGAPTAAKKDLAVVEDRDINILNIVSNFKQEIDGPVTLIKQGAGSTALTQNNLQEYLTTISNAIGSTTAQVQALQKRDLSEMTPEMQKRQADLVNEVGQLLAGVIQEVVEALQVIGADLAGIPIIGNLIASIIPGLNTLLIGVDLVLAGVLLVVQSLLGNVAGLLNGVLGGLGLGGLLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ6</accession>
    <name>A0A1Y1UAJ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_633665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869248.1">
        <property type="nucleotide sequence ID" value="XM_022016643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAJ6"/>
    <dbReference type="GeneID" id="33558452"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ6"/>
    <dbReference type="OrthoDB" id="2563792at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="267" mass="30233" checksum="29ECF6F712B2C859" modified="2017-08-30" version="1">MLALGTSTAIRFCKQGGSDFILNAFSQGVRHFDTAEDYFNEEVLAEPLGTTSGRREQAFITTKFGRHDKTAQNVRESLNKSLKKLRMDYVDLYLVHDPAWYKEGSLGEIWAAMEKLKEEGLCRAIGVSNFQEHHIEELARTWRIVPSINQVEMSPFCAHDAMFQGIQRACEKHGIVISPYTSLAPLHHKQHPPLDEAVQRIGRARGMSDTQVLLAWALQTGKGPVVTATAKLERVQDYLGTFAFVLQPEELEEISRVGKQVSYRRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAR7</accession>
    <name>A0A1Y1UAR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_653366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868859.1">
        <property type="nucleotide sequence ID" value="XM_022018647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAR7"/>
    <dbReference type="GeneID" id="33560456"/>
    <dbReference type="InParanoid" id="A0A1Y1UAR7"/>
    <dbReference type="OrthoDB" id="2572507at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="71" mass="7597" checksum="06D6207A9095BEAF" modified="2017-08-30" version="1">MDKTSYPPQPSIESTYVAMQPTKQATMNAAKPSDGVSKQSEETLRLRGGCPGAFGSEQTGEDPPCCWCGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAT7</accession>
    <name>A0A1Y1UAT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prenylcysteine lyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_652897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868869.1">
        <property type="nucleotide sequence ID" value="XM_022018574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAT7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAT7"/>
    <dbReference type="GeneID" id="33560383"/>
    <dbReference type="InParanoid" id="A0A1Y1UAT7"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012078748" evidence="8">
        <location>
            <begin position="25"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="9">
        <location>
            <begin position="206"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="582" mass="64891" checksum="D0A03BFE97287658" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAV6</accession>
    <name>A0A1Y1UAV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_634335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868889.1">
        <property type="nucleotide sequence ID" value="XM_022016716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAV6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAV6"/>
    <dbReference type="GeneID" id="33558525"/>
    <dbReference type="InParanoid" id="A0A1Y1UAV6"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040221">
        <property type="entry name" value="CDCA7/CDA7L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169">
        <property type="entry name" value="OS05G0300700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31169:SF8">
        <property type="entry name" value="ZINC-FINGER DOMAIN OF MONOAMINE-OXIDASE A REPRESSOR R1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Zinc-finger" evidence="11">
        <location>
            <begin position="207"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="458"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="64626" checksum="B0EAD502B4E386D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBQ0</accession>
    <name>A0A1Y1UBQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869660.1">
        <property type="nucleotide sequence ID" value="XM_022016579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBQ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBQ0"/>
    <dbReference type="GeneID" id="33558388"/>
    <dbReference type="InParanoid" id="A0A1Y1UBQ0"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="147" mass="16183" checksum="3BC2F183F952C30D" modified="2017-08-30" version="1">MFEKLKEKLGAHSKTHPLAAQRDEFLAADMNTPLERKAHFSHEVVGAAAGYEALRAFENHEAHSTGTKVTHARAKEIVAGLASGFVVKLVEDKGLPFTSEADKHKFIAEAQHTASRDSKRTLRESGIFDQNELDPIDNDEKHAAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBV7</accession>
    <name>A0A1Y1UBV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_682309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869692.1">
        <property type="nucleotide sequence ID" value="XM_022019145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBV7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBV7"/>
    <dbReference type="GeneID" id="33560954"/>
    <dbReference type="InParanoid" id="A0A1Y1UBV7"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="250" mass="27468" checksum="DA726697985ACC2A" modified="2017-08-30" version="1">MLSERDNSILVKIFDPEAQPESSARISANAVPLPGIPIDLFGELATRERRTLQPLNQDFPTPERIHQAIKELSSIIKSHPLYASAYVNRAQARRLQIQYDELFSPDAESMMVDIFADLDRAVDLAAPLRSLDQISAHQGNLLAAAHTHKGLLLLRAADITRGGAPAHGLPPALANMDADVLEEAASHELASGGRYGNTMAQQLAVKTNPYAKLCGSIVREAQRKEILETMRPHTFECVLVLPRCLADRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC52</accession>
    <name>A0A1Y1UC52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_630899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869792.1">
        <property type="nucleotide sequence ID" value="XM_022016383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC52"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC52"/>
    <dbReference type="GeneID" id="33558192"/>
    <dbReference type="InParanoid" id="A0A1Y1UC52"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="265" mass="29122" checksum="08F8F5B7AE2BA69F" modified="2017-08-30" version="1">MRFCFRPKSFILPVQSILQQLFKLFGHFVPLLSQQRPTMSQRLIPRAYSSLTAMSAASGSSFSSVMMIGGLRTFSSTSIPSRPPPNGFESFAGSLANILGSQAASSSSSNGSTPQTQTEAMLKDMGAAADGRRTNFHPGATISPSELTRERLFPGSFRPRRKPPLFGPQEGKARQRDPFILANSHPLEHTYNARLIQAFLDPMGRIKPRSETQLSKKSQKQVGKLVRRARSMGIISVWNNSPSKAGYGRMPSSGLSFDFEDDSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC63</accession>
    <name>A0A1Y1UC63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_582509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869302.1">
        <property type="nucleotide sequence ID" value="XM_022013564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC63"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC63"/>
    <dbReference type="GeneID" id="33555372"/>
    <dbReference type="InParanoid" id="A0A1Y1UC63"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="633" mass="69189" checksum="A6BFFDB184352D37" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCD1</accession>
    <name>A0A1Y1UCD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_72485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869865.1">
        <property type="nucleotide sequence ID" value="XM_022019227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCD1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCD1"/>
    <dbReference type="GeneID" id="33561036"/>
    <dbReference type="InParanoid" id="A0A1Y1UCD1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF13">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="156"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="281" mass="31124" checksum="264FB5520BE68787" modified="2017-08-30" version="1">MLQYTYDMMAENHPIYNTMQSFEQERARIYEQIDAGKLDFGAHRRGKELLAKITRLKQAIAQDVLADADVICTTCLSAAGSRILGQIDFPIVFLDEASMATEPLSLIPFMKGVSGSISCRPACADRCLKSSQVAIIGDHKQLPPVITSDAAKFGGLSMSLFERLVHEQYLKDSTVMLDTQYRMHPSIAAFASKQFYNSELKNGTTSVITGKPLKKFDPPVSKYLTTTSGEKRNVMFVDHDSVEMSSDDKSTVNYGEAQQGHWYHRAVCGSNSTTHCLSSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCE2</accession>
    <name>A0A1Y1UCE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_652257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869877.1">
        <property type="nucleotide sequence ID" value="XM_022018465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCE2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCE2"/>
    <dbReference type="GeneID" id="33560274"/>
    <dbReference type="InParanoid" id="A0A1Y1UCE2"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="720" mass="77549" checksum="5246BCE02AB50B98" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCE7</accession>
    <name>A0A1Y1UCE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylenetetrahydrofolate reductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_631379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869884.1">
        <property type="nucleotide sequence ID" value="XM_022016429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCE7"/>
    <dbReference type="FunCoup" id="A0A1Y1UCE7">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCE7"/>
    <dbReference type="GeneID" id="33558238"/>
    <dbReference type="InParanoid" id="A0A1Y1UCE7"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="309"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="639" mass="71648" checksum="8356C90F17BE30E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCL8</accession>
    <name>A0A1Y1UCL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IPP transferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_631705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869954.1">
        <property type="nucleotide sequence ID" value="XM_022016455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCL8"/>
    <dbReference type="FunCoup" id="A0A1Y1UCL8">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCL8"/>
    <dbReference type="GeneID" id="33558264"/>
    <dbReference type="InParanoid" id="A0A1Y1UCL8"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="563" mass="62463" checksum="8E267151140464A4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDC6</accession>
    <name>A0A1Y1UDC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870169.1">
        <property type="nucleotide sequence ID" value="XM_022016275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDC6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDC6"/>
    <dbReference type="GeneID" id="33558084"/>
    <dbReference type="InParanoid" id="A0A1Y1UDC6"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="702" mass="78081" checksum="BC8D2606C89D3901" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE23</accession>
    <name>A0A1Y1UE23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Muts domain V-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_631573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869928.1">
        <property type="nucleotide sequence ID" value="XM_022016449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE23"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE23"/>
    <dbReference type="GeneID" id="33558258"/>
    <dbReference type="InParanoid" id="A0A1Y1UE23"/>
    <dbReference type="OrthoDB" id="2596045at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="673" mass="74120" checksum="E5B5851CD81B6D9B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC1</accession>
    <name>A0A1Y1UEC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 9">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aguA</name>
        <name evidence="14" type="ORF">BD324DRAFT_656826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 9"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEC1"/>
    <dbReference type="InParanoid" id="A0A1Y1UEC1"/>
    <dbReference type="OrthoDB" id="6501611at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="11">
        <location>
            <begin position="502"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="13">
        <location>
            <begin position="632"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="12">
        <location>
            <begin position="952"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148443" checksum="7AD2514232E7C6D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UES2</accession>
    <name>A0A1Y1UES2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870143.1">
        <property type="nucleotide sequence ID" value="XM_022016267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UES2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UES2"/>
    <dbReference type="GeneID" id="33558076"/>
    <dbReference type="InParanoid" id="A0A1Y1UES2"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="37869" checksum="46F76594018D9992" modified="2017-08-30" version="1">MPRLQILQHKSYHPYLEKNKQRVREDEARAAAEELANEQRRVDAEASGRLDLLRRRAGSPSLDDNLPSTSSSRPGESSLLERHRKAKAKAEKEERKRKERLDFDFPSETARKARDGRREADGYDVDGDGREAIKWESGGHVNFFTDIEKSEAGPSLAEMAKKKDKDKEDPYTMYLARPDKETKPWYSDKDLRRIEEWESGDQAEERRARDRRKDQRSKSRNDPLTHITSLLSTHSSTAQKKPHVRVPPPGSDPQTARMAREQSERQRALALIAKTKAQTQNPWDSTPSTVVGRNWSDDFEREKDRAGRRYFTGGQYDTPERRRRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF10</accession>
    <name>A0A1Y1UF10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Velvet factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_609277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870225.1">
        <property type="nucleotide sequence ID" value="XM_022014148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF10"/>
    <dbReference type="GeneID" id="33555956"/>
    <dbReference type="InParanoid" id="A0A1Y1UF10"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="11"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="479" mass="53330" checksum="DDB1801A91FD1566" modified="2017-08-30" version="1">MTTASLGLDHSCVLRKYELQMRQQPVQARMCGVGEKSDRRPVDPTPIIQLKVIDTDADPLRRPDSGPHGMTYMQNPYYFLFACLVGDEDNELHVIDDGKTRFLTGTPVSSLYHLKDLDNSDAAFFVFPDLGVRKEGRYRLKLTLFEIIEQEVYYCTTTFTDTFSVFSAKKFPGMQRATDLSRSFAEQGLKIRVRKDVRKPTVKPKRKSTAQDSESESIPETKRARPHHSAEPRSYQPEYPYPPQPSYFYNTHGGAQPMPPPPVPYDPYRQQPAATYSFRGQPQPQPQPHPHPHPQHPPPRHSVARHSLPAGYPRAMPPGGGSTHGPHDYHAWQHQERSRAHASGARPITPDMHGQSRDYRRRSPAYSSPPPPPPAQQTSSSSTSVRSPRRSGRQDPLPGYRSTDGAKSPPSWRMSPNHRHSALPPLNIPPHTLSNGPDGRDVNPGMNGSDSTASPVSGGVRPNGGGKPANRMGLGHLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL9</accession>
    <name>A0A1Y1UFL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870912.1">
        <property type="nucleotide sequence ID" value="XM_022018315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFL9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFL9"/>
    <dbReference type="GeneID" id="33560124"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL9"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="587"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116791" checksum="EFB0FEFBCF29C8CF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFN7</accession>
    <name>A0A1Y1UFN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_489967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870448.1">
        <property type="nucleotide sequence ID" value="XM_022012928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFN7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFN7"/>
    <dbReference type="GeneID" id="33554736"/>
    <dbReference type="InParanoid" id="A0A1Y1UFN7"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="272" mass="30239" checksum="4D93D1ECEED86EB6" modified="2017-08-30" version="1">MSEDQDEVSIYCSLDHSSINDEGENTIVFIHGAFGDGSGWKDVVSHFKDQHLLLPDLPAHGVARHLDRFSVPRASRLLRELIVRKAHGGKAKVVGFSLGAQVAVHLCSTYPEVIDETVFVSGYGGPSSPTESPRRFLPYAAWMSQRVEYALPRGLIRYMMDGADMPRGDLSQHTLSLYRDIFTPEIKTDWPEPWPARTLIVVAGKGDLIPSADNPNVAKRLASIGQKGNVSTLAVTHPLMRHPWLLQDPELFARAVMAWFERAEIVDGFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGB2</accession>
    <name>A0A1Y1UGB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_579736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871100.1">
        <property type="nucleotide sequence ID" value="XM_022013405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGB2"/>
    <dbReference type="FunCoup" id="A0A1Y1UGB2">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGB2"/>
    <dbReference type="GeneID" id="33555213"/>
    <dbReference type="InParanoid" id="A0A1Y1UGB2"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="120" mass="14186" checksum="DB39AF3456E16759" modified="2017-08-30" version="1">MQAHEGVILPLPGADGSARSPERYGNIVRFQSELEFVQCLANPLYLKELYTQGLLDNAEMLNYLKYLDYWREPEYVRFIVYPTCLVYLTLIQQETFRSRLGDPAFIEELRRLGTRHHETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGC7</accession>
    <name>A0A1Y1UGC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871159.1">
        <property type="nucleotide sequence ID" value="XM_022015745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGC7"/>
    <dbReference type="GeneID" id="33557554"/>
    <dbReference type="InParanoid" id="A0A1Y1UGC7"/>
    <dbReference type="OrthoDB" id="2564338at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="51101" checksum="A09D0997515DDC44" modified="2017-08-30" version="1">MSRSSLIRDLSSRVVSSGPSQLRPCLAVASSSARPLAKRRISSTVSCQAAPVADEIARDTKRGVVQIPHPSLDAIHGSTRLLLKPSSLPSLVHAYAIVRAVEAHFQTSVVSVEVGMSPDLFMPSHRIHITLLKPVILEKPLHLITPLPEMTMEDVDLFGPSLEDIQRVLDSPGQVEDRDGDSGPISQLAEDAKLSFRVETLPAESRAPIPNPPKLPPGLYRDQLRRRQEKVAADVKIYAAVEKLKEVSNGEFDELLEKFSHFKSAASSPASQQQVGGQSLLNLPEEDPSAPAFDFALRKESARSSSVRSSTHSQRPDAEDPNSDARKRQSFNLSALPGRSASKLSAQPSKEDGAMVEWSRSAVAESQSTKRSKSSASTRAGKQAKPKPAEEEDLYVRLELMRKQEEKRAAAEAAERKAEKNREAKVLQEQRREAELDQQRQEEKANSTIGRMGRMLNDAAKRWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGE9</accession>
    <name>A0A1Y1UGE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_642076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871087.1">
        <property type="nucleotide sequence ID" value="XM_022017462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGE9"/>
    <dbReference type="FunCoup" id="A0A1Y1UGE9">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGE9"/>
    <dbReference type="GeneID" id="33559271"/>
    <dbReference type="InParanoid" id="A0A1Y1UGE9"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000187">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="165"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="612"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="252"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="850" mass="92928" checksum="405445F094D98F96" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGH8</accession>
    <name>A0A1Y1UGH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_608479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871117.1">
        <property type="nucleotide sequence ID" value="XM_022014113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGH8"/>
    <dbReference type="FunCoup" id="A0A1Y1UGH8">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGH8"/>
    <dbReference type="GeneID" id="33555921"/>
    <dbReference type="InParanoid" id="A0A1Y1UGH8"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="243"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="418" mass="45426" checksum="B8302601F00B8A80" modified="2017-08-30" version="1">MSPSSPASSSSSLPSSNVLLALPDGAIPSGHEDAKSHTISTIGGYPTFPPLSSQDKAPEEIRCGICHQAIPLLAQVYCPPEDGENDRTVYVWACARSSCQRRDGSVRAYRASLRNDEYAIDAAAKRAAAAKAAEAERERARKNPFSMPASGDGKSLFGSAQPLFGAPPSADLSNPPDISSLSLQPNASTSHAPPLPAYQPPQYLTTIDEYLAPPEDVDMDDDEEDQMDLRNERWEQLLPKHMDEVFERYVKRLKDADGGAGQVLRYELGGVPVPYSSKSPLYSRLFPGAPITRTPDAEEEPDFADFYNPESLPPCSRCGAKRVFELQLVPSLISILSPDKLTTTGKAPSKKERKQSEEERKKDLARIAAGLKGQGDEQEIGDMNWGSILVFGCEADCVGVGEEFVAVEWESFLSETSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGV2</accession>
    <name>A0A1Y1UGV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_650805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871237.1">
        <property type="nucleotide sequence ID" value="XM_022018205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGV2"/>
    <dbReference type="GeneID" id="33560014"/>
    <dbReference type="InParanoid" id="A0A1Y1UGV2"/>
    <dbReference type="OrthoDB" id="2591446at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="85" mass="9049" checksum="C95A11E0F4CC1907" modified="2017-08-30" version="1">MTPLTYFQVVCRILALLLLAPFALCIALDVTAYAIARTLHLSMSHQRVPRSPGSQVIPILTEGEIATFDDGFGVPNGSAAGSKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGZ5</accession>
    <name>A0A1Y1UGZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_466949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870843.1">
        <property type="nucleotide sequence ID" value="XM_022012865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGZ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGZ5"/>
    <dbReference type="GeneID" id="33554673"/>
    <dbReference type="InParanoid" id="A0A1Y1UGZ5"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="934"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="848"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1020" mass="108932" checksum="313650598C3E23EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH97</accession>
    <name>A0A1Y1UH97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_626033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871440.1">
        <property type="nucleotide sequence ID" value="XM_022015865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH97"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH97"/>
    <dbReference type="GeneID" id="33557674"/>
    <dbReference type="InParanoid" id="A0A1Y1UH97"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="74"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="456" mass="49416" checksum="1E476DB7B0D007EA" modified="2017-08-30" version="1">MTEVIRFTNGFLAMPDGTVSRYKWSLCHDLTLLIQAVKADLYISPSTGTIVSGQSSFFDSHRPPARTIDLGGNILAPGLIDVQINGAYGVDFSELNGDDADGGEERYIKGLETVASRILETGCTGYVATIITQKEEMYRKLLRLLQPRSPPNAAHVLGYHAEGPFLHPLRRGAHSQTLLMTAAPKAGSTPKDILEKVYGKEGLDQEGVKMITAAPDVEGVMDCIPDLVSRGVTVSIGHSDATLEVATEAMHKGARMITHLFNAMPPIHHRDPGVIGLLGAHDQRPYFGMIVDGLHSHPNTVRIAYGACPERCVLVTDAQSIMDPNLPDGVHDWRPGLKFRKDGYRVVIDGTETLAGSCSPFPYLLRNLCSFTGCTLPQALVTATLHPAQMLAGKIAQTKGQLKEGFHADLCVFDWDGYCRSTWVMGKEVWRDAQFGKPGEGNSLAGSRATTNGHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UID1</accession>
    <name>A0A1Y1UID1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_623414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871797.1">
        <property type="nucleotide sequence ID" value="XM_022015578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UID1"/>
    <dbReference type="FunCoup" id="A0A1Y1UID1">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UID1"/>
    <dbReference type="GeneID" id="33557387"/>
    <dbReference type="InParanoid" id="A0A1Y1UID1"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="149" mass="15543" checksum="2BE0E775B7354E1A" modified="2017-08-30" version="1">MDPSMAGPQVAQPPVPGAPAPGDTSSTAGKASPLFPPAVQHNVRVLSSLSTLSACFSGLVAGVLGLQNYTGFLLYLLTAVSSALVFGIINCHGNMGKYVAGSHVPLVGSDRIGVRKWRGWVGLMGLGQENFLGFLLFWIGGYALIHVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIH1</accession>
    <name>A0A1Y1UIH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_681645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870964.1">
        <property type="nucleotide sequence ID" value="XM_022019127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIH1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIH1"/>
    <dbReference type="GeneID" id="33560936"/>
    <dbReference type="InParanoid" id="A0A1Y1UIH1"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="295"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="46326" checksum="FA6A3744CCD1FABE" modified="2017-08-30" version="1">MVNGEVVAYNFASLICALFVLEKGADIFIDHTAIVALRTGIPKSAIALLTAGAEWEELAVVVISLARNRSSLAIGNVVGSAIANILGAFSLGLIFYRNPSGNPVLFERSSVVYSVALLGLTAIASALLAFGGHVQFKAAGGAFIALFVVYLSSISWLIFKGVTKAPEELSDSDSDSDDGSSDTTSENGVNEERQTRSRRGDLRPPSQNTGSRFHEELDVAPLTVGQATTVVEASTSKGINPPIPNSSETAEETIARLRRGSSRRSNVTNTTTSGASSNPDRSPKAGKARSLAYHFTVLLAGFLAVVLSGYVISNAASNVVDELGLSDVLGGVVILSIATTIPEKLVAVLSGYKGHMDIMLANTVGSNMFLLTLCLGIIWAATGGSYSGGDVKPAEIITMFASTVVLAVTVLLRGKLPRAVGVIMLMGYITFLVLEFTVIHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIM4</accession>
    <name>A0A1Y1UIM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin motor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_623652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871868.1">
        <property type="nucleotide sequence ID" value="XM_022015611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIM4"/>
    <dbReference type="FunCoup" id="A0A1Y1UIM4">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIM4"/>
    <dbReference type="GeneID" id="33557420"/>
    <dbReference type="InParanoid" id="A0A1Y1UIM4"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="102"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="962"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="590"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="764"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115185" checksum="0C638AE370785693" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIS4</accession>
    <name>A0A1Y1UIS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_650503</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871950.1">
        <property type="nucleotide sequence ID" value="XM_022018155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIS4"/>
    <dbReference type="FunCoup" id="A0A1Y1UIS4">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIS4"/>
    <dbReference type="GeneID" id="33559964"/>
    <dbReference type="InParanoid" id="A0A1Y1UIS4"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013186275" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="623" mass="71017" checksum="9EAABB8C0F3F1CB6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIW7</accession>
    <name>A0A1Y1UIW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871968.1">
        <property type="nucleotide sequence ID" value="XM_022018160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIW7"/>
    <dbReference type="GeneID" id="33559969"/>
    <dbReference type="InParanoid" id="A0A1Y1UIW7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="48927" checksum="CB175B1E777C4703" modified="2017-08-30" version="1">MSLMSLPDEILRNVVRQLDQVSQLVLAQTSRPLQYLAEEELYCSLADSFFCAHRQFDHERGLRAKHAKLLSSLKGCDHRRAYVKTLSVTLYPFVVQEPIAKTLKLTAGSLRSLRLEQTATCFPPPILSDLNITFQNLAPLPHLTHLELTLSFMVTPLLNQLLKLAPQLSSLTFRRPSLPHFDPRPFGLDTTLVLPHLKNFKAEKMSKSNLMVVVDLLRLLPSLEALSLSSITMLHDSKLWLPVVEHLRPRAIQSLQVGFSSMWDFDARGGFLHVKELTLRWDYDDCWFPLLQDICVPPLPMLESLTFEAIQGLQHKLLHGCQRARVDLSDGITSRTIPSSLVARIMAAPRLEQIFFLPPQQDYLQDPSVEHVEFVEIHRGSLRESGIEPGLALRVFSHVLDHGEGLQSHLREPHPPFKFNVNISEAFNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ00</accession>
    <name>A0A1Y1UJ00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent protein kinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_650577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872030.1">
        <property type="nucleotide sequence ID" value="XM_022018170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ00"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ00">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ00"/>
    <dbReference type="GeneID" id="33559979"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ00"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF124">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="485"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="555"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="856"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="840"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="857"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1142" mass="125095" checksum="26C0708D987905E5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJD9</accession>
    <name>A0A1Y1UJD9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coagulation factor 5/8 type domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872090.1">
        <property type="nucleotide sequence ID" value="XM_022018010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJD9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJD9"/>
    <dbReference type="GeneID" id="33559819"/>
    <dbReference type="InParanoid" id="A0A1Y1UJD9"/>
    <dbReference type="OrthoDB" id="5186230at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801858" evidence="1">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="298" mass="32657" checksum="9D2FB13C167BC09D" modified="2017-08-30" version="1">MFSLLALPLLAVAAAVPVSRQDSGGVKELWLFNDIRVSDANAIKTAGYDTVIMFQLGIFANASLAYYGDEKGQNDNPVLLVDGGVYVEDIGLADIVTGYKTGTTTIDRTEITIVSGNVFWQRIQAMVEANGTGPDTALYQNFAALKTAWNLDAINDDDEENYDVSSTVAFAQMLGQIGYKFTTAPYTNTFFWAQVGQGINDANLYDRSYLQCYDGGEGNDPGLWAFEVGMPQVPLLWVTNTDKPQDGNTPAQVQSQMQQWKDTYGSNIAGGGLWNDYDIYYNNNSYQTYAQALEAVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKH4</accession>
    <name>A0A1Y1UKH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUR7/PalI family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872475.1">
        <property type="nucleotide sequence ID" value="XM_022018062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKH4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKH4"/>
    <dbReference type="GeneID" id="33559871"/>
    <dbReference type="InParanoid" id="A0A1Y1UKH4"/>
    <dbReference type="OrthoDB" id="3365245at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="67372" checksum="30122F0D8F983AB1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKU6</accession>
    <name>A0A1Y1UKU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_621908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872595.1">
        <property type="nucleotide sequence ID" value="XM_022015420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKU6"/>
    <dbReference type="FunCoup" id="A0A1Y1UKU6">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKU6"/>
    <dbReference type="GeneID" id="33557229"/>
    <dbReference type="InParanoid" id="A0A1Y1UKU6"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="246"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="753" mass="83518" checksum="F7E52E50A3AB9E0F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKV6</accession>
    <name>A0A1Y1UKV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WIBG Mago-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_621921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872603.1">
        <property type="nucleotide sequence ID" value="XM_022015422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKV6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKV6"/>
    <dbReference type="GeneID" id="33557231"/>
    <dbReference type="InParanoid" id="A0A1Y1UKV6"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="38329" checksum="E831CE239917A93F" modified="2017-08-30" version="1">MSLPPVNPEKTASGIIQDPRTLERIVPTSKRSDGSVRKELKIRPGFTPQEDIGRFRSNRQVAADARKGLVPGSNRPPPPKQPDPDNVFAQPAKEKSKAQLKNEKRREKKRLEASNKDWDDDEDGDEHVLEDGQTAVEIPGSKEATGGGIYNPEDSFTPFSNHGTPDPPAIQPKSQGSNIPASKPSDGANINWADMDDSPVGISASPPSAPELASAIQASASTSKSNPSEAAANSRTAGPAAKRHPIQGGRDGPLGLAHPPPIEQSKSDKATSWRKEKPPAENPGKGAGAKSKGKSGNTKPAAGPKGAAEPPKPTSEPRVRKEVKIRQGGVNDIGSLASRVRSLVLENQKPAAPRAKKENAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKX0</accession>
    <name>A0A1Y1UKX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_670520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872076.1">
        <property type="nucleotide sequence ID" value="XM_022018932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKX0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKX0"/>
    <dbReference type="GeneID" id="33560741"/>
    <dbReference type="InParanoid" id="A0A1Y1UKX0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="512" mass="56013" checksum="828C0BC8AD950D89" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL19</accession>
    <name>A0A1Y1UL19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Siderochrome-iron uptake transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_641484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872116.1">
        <property type="nucleotide sequence ID" value="XM_022017423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL19"/>
    <dbReference type="FunCoup" id="A0A1Y1UL19">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="33559232"/>
    <dbReference type="InParanoid" id="A0A1Y1UL19"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000412">
        <property type="entry name" value="SIT1p Ferrioxamine B transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="595" mass="65088" checksum="41815F82E47BC694" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL64</accession>
    <name>A0A1Y1UL64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_641745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872651.1">
        <property type="nucleotide sequence ID" value="XM_022017443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL64"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL64"/>
    <dbReference type="GeneID" id="33559252"/>
    <dbReference type="InParanoid" id="A0A1Y1UL64"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="32"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="457"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="681" mass="74902" checksum="EA0313DE04623ADF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL68</accession>
    <name>A0A1Y1UL68_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_379965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872654.1">
        <property type="nucleotide sequence ID" value="XM_022012631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL68"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL68"/>
    <dbReference type="GeneID" id="33554439"/>
    <dbReference type="InParanoid" id="A0A1Y1UL68"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="440" mass="47662" checksum="564011798EAAF9D2" modified="2017-08-30" version="1">MATVLSRLYHELGLGSVWDSGRDVWLVLLARSARMFAYGANSLILALFFSQLSFSDFRIGVFMSLTLLGDVVLTVALTTTADRYGRRRTILLGSVLMVISGLAFVLVENFWILLMAAVIGVISASGGDFGPFRAIEESMLSQITTGKARNNVLAWYVTTASLGSAIGTETSGRMVDGLLSHGWSRLDAYHTIFGLYVMMGALNAVLVLLMGDRLEAARPVAPEDEMMLLEEEPGTKPQPQPQPQASSPWSLSLSTRTVMYKLWPLLALDSVADGMVSYSLTTYYLEQKFHTTTATLGDITSVSYFLAAASTIFAGPLANHIGLVNTMVFTHVPSSAAVLLFPLPSHLVLTVILFFIRTGLNNMDQAPRSAFIAAAVKAEERTAVLGLTSTIRTLAATAGPSITGILAQSGRFWLAFVVAGAFRLLYDFGLWALFINMKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULE6</accession>
    <name>A0A1Y1ULE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_620587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872289.1">
        <property type="nucleotide sequence ID" value="XM_022015300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULE6"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULE6"/>
    <dbReference type="GeneID" id="33557108"/>
    <dbReference type="InParanoid" id="A0A1Y1ULE6"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="252" mass="27833" checksum="154AFE5AF828FD7E" modified="2017-08-30" version="1">MYSVDIKMTLARLAKVMSSLGGLDSCLMLAQFSSPFIIALLLRLARLRASLARHVGVDKVGSEAQLYKRVEGITKAAGGISEARVIMRAFGLLPVILGLAKLHPKPIQSLQGITGALSSPKAIPTVQALSLAGYYSMEQLAWLGGKGVLDIAPLKIKQMSLWSVRCWAVYVFLELFKLNQTYSALRTRTRAIRSAKPKVSAKEAEGYEIPSVESTTVTEEKKPGVKNDNKQLDKEQLRKDWDTWRLSTLTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULJ7</accession>
    <name>A0A1Y1ULJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_620524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872278.1">
        <property type="nucleotide sequence ID" value="XM_022015295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULJ7"/>
    <dbReference type="FunCoup" id="A0A1Y1ULJ7">
        <property type="interactions" value="643"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULJ7"/>
    <dbReference type="GeneID" id="33557103"/>
    <dbReference type="InParanoid" id="A0A1Y1ULJ7"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="118"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="28539" checksum="D1827D467209646A" modified="2017-08-30" version="1">MFANQHNAYSSSQPYAASAEPLAFFNGANAAGSSSSSPYYSGSRSSLEGNMGVGGGGAGAGGYATGTMSSSARLGNMVSSGEGRWWEAFGTGGLDGEPSLMEELGINPSHILQKSLTVLNPLSRVDEHIMDDADLAGPFVFCFAFAFVLLLSGKPQFSYIYGVGLLGTTAIYLLLNLMSDNGIDAYRTASVLGYCLIPMIFLGSLGIGIGIDSAIGYILSVISIIWCTHSASQIFVSVLRMDHQRLLVAYPVGLLYGCFALLSIFNVNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULK2</accession>
    <name>A0A1Y1ULK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872725.1">
        <property type="nucleotide sequence ID" value="XM_022014937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULK2"/>
    <dbReference type="FunCoup" id="A0A1Y1ULK2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULK2"/>
    <dbReference type="GeneID" id="33556745"/>
    <dbReference type="InParanoid" id="A0A1Y1ULK2"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="185" mass="20880" checksum="93BA654E46E2B85B" modified="2017-08-30" version="1">MQGIESSAFFVNSRDQVMLFERKASEISSSGYKSASQLPVYLHELLGDLSHSLKPRLPAHVWTTVFRQDLARQVIINLYEPGQGITPHVDLINRYADGIVGVSLCGSASMTFEHIARPEERYHVFLPSRSVYVLRGSARYDYSHGIEGRALDLVNRGDGRIDTILRESRLSITFRWIKEGGDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULU2</accession>
    <name>A0A1Y1ULU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_649863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872419.1">
        <property type="nucleotide sequence ID" value="XM_022018054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULU2"/>
    <dbReference type="FunCoup" id="A0A1Y1ULU2">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULU2"/>
    <dbReference type="GeneID" id="33559863"/>
    <dbReference type="InParanoid" id="A0A1Y1ULU2"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="126"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="267" mass="28409" checksum="B9A35CCCB4E3E072" modified="2017-08-30" version="1">MAYDRVNSPSHQIIQADDDDLEALSFSHPSAAQASSSSAGVAAAGPSTAPGSGSQLNGGLSGKIGSGPTPGSTSRTGWGGVTIETRYTGESTLDEPVSATIMRDLRSIYAKLLQVVYPPKGGGSNELLRDWDLWGPLVICLSLAIILSVDAPTTQAMPVFSLVISLITIGSVVLTINCKLLGGKVSFFQSLCVLGYALAPILLASVISLLVHNLFVRIPISLACWAWSVWASMNFFNGTQLPETRIWLAVYPLCLFFFVLAWMIMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULX9</accession>
    <name>A0A1Y1ULX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_680224</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Prevacuolar compartment membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872416.1">
        <property type="nucleotide sequence ID" value="XM_022019072.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1ULX9">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULX9"/>
    <dbReference type="GeneID" id="33560881"/>
    <dbReference type="InParanoid" id="A0A1Y1ULX9"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000007">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299389" description="Vacuolar protein sorting/targeting protein 10" evidence="17">
        <location>
            <begin position="24"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1368"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="18">
        <location>
            <begin position="46"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="18">
        <location>
            <begin position="728"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX38494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1472" mass="163804" checksum="74A4C82225FFDD04" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM03</accession>
    <name>A0A1Y1UM03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">BD324DRAFT_649165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM03"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM03"/>
    <dbReference type="InParanoid" id="A0A1Y1UM03"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="963" mass="104009" checksum="9EC1384F11348233" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMI7</accession>
    <name>A0A1Y1UMI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_578018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872267.1">
        <property type="nucleotide sequence ID" value="XM_022013293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMI7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMI7"/>
    <dbReference type="GeneID" id="33555101"/>
    <dbReference type="InParanoid" id="A0A1Y1UMI7"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012643670" description="Chitin-binding type-4 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36753" checksum="1E920F8B31C4A423" modified="2017-08-30" version="1">MSCPTLVALLALSAPALAHMQMSWPYPLRSSFNPKNNWENIDYSMTNPLGVGQYPCKGYINNPREEMYPVTSWTAGSTVTITLDDGVTHKGGSCQLSLSYDDGKTWSVIQSYMGGCPIDSLSYDVEIPSDAPSGDAIFSWSWFNWEGNREMYQNCAVVTIQNGGSGLDPIRYPPPFVANVDAAPGCATIEGVSVVFPNPGANVRYGGEYRDSKPTKPTGFTGDCGAQSPIPSSSPSPPPSQSKPAHSSTAAAHSSAIASRPAPTRETLPSSPVSAAAQHEPSKSPGSTKCKRKVKGSVVRRTNVAKRHERLVRHYQHERLAPQVVGRAESDGSWGGSSQRSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMU9</accession>
    <name>A0A1Y1UMU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">S5 DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_576679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873246.1">
        <property type="nucleotide sequence ID" value="XM_022013203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMU9"/>
    <dbReference type="FunCoup" id="A0A1Y1UMU9">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMU9"/>
    <dbReference type="GeneID" id="33555011"/>
    <dbReference type="InParanoid" id="A0A1Y1UMU9"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="34895" checksum="F90C766CE928EC7D" modified="2017-08-30" version="1">MRLSRGALRQLAGTRALSTAPSAQHAAPVASSSSSTPSTSSSSSSSASSSSATPAEVESSRPPILPFFPIPRPPNFPGKFRPNNGEYPTVNFVNFPYPLWKPTAAKDLPKDTVGGDHREKNQKILAAMTGLEVKELNDLRRMLIKQQRVSHMTKKGRMRGMVAWMLVGDPNKGLVGLGRGAAKSGPAAVDKAFYQACKNMDYVDRYENRTLWGSGKELRGKFESSVVHLRARPPGFGLFVPHSVHKVLSMCGIKDASAMIVGSTHLVNVTKCVIQMLHGGANPPGFGSGFSTAGKVENKGHGMRTKTEIERARGRYGVNIGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMY8</accession>
    <name>A0A1Y1UMY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_621090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872417.1">
        <property type="nucleotide sequence ID" value="XM_022015357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMY8"/>
    <dbReference type="FunCoup" id="A0A1Y1UMY8">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMY8"/>
    <dbReference type="GeneID" id="33557166"/>
    <dbReference type="InParanoid" id="A0A1Y1UMY8"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="161"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="532" mass="60195" checksum="D0FB9A34C0DB59BF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNI0</accession>
    <name>A0A1Y1UNI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VIT family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_614330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873396.1">
        <property type="nucleotide sequence ID" value="XM_022014585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNI0"/>
    <dbReference type="FunCoup" id="A0A1Y1UNI0">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNI0"/>
    <dbReference type="GeneID" id="33556393"/>
    <dbReference type="InParanoid" id="A0A1Y1UNI0"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="403" mass="42710" checksum="C92BA4160ED347AC" modified="2017-08-30" version="1">MTLPSSSNSINNTNNSQNLSSSAQQPIALSRSPRGESSPSTFTPVWSVDPPPPRPPPESAPPLGARTSVHNLQAQLDHLTKGDEPLSEKCQVQQMHRETCCKELKGEDERHLIAPAVVRDIIVGLSDGLTVPFALTAGLSSIGSSRLVVTAGLAELCAGAISMGLGGFLASQAELDHYKYLQRQTHARVVRSCAAQMEREVHELLGPYGIKEVTSRLIVDQLAGLEGGGREHRSPKNSMGIEGVYTPAPPLPLAPSPPPRRNISRFNFQALFRSNDTAETGSIGPSEDIGLTPFLVKFGEGMEAVSISRLWISALTIGMSYFIGGLVPLIPYMAHADTRNGLIISASVTGLVLFIFGAFKTYFTGAKGGFGGYLYGATSTLIVGAIGAGAAYGLVRAMNVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNJ7</accession>
    <name>A0A1Y1UNJ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_614413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873416.1">
        <property type="nucleotide sequence ID" value="XM_022014593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNJ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNJ7"/>
    <dbReference type="GeneID" id="33556401"/>
    <dbReference type="InParanoid" id="A0A1Y1UNJ7"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012711280" description="FAD-binding domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="292"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="390" mass="41852" checksum="227E75D26EFC4F4E" modified="2017-08-30" version="1">MAAGSTLPVLISGAGLASLLFAQSLRRSKIPFVIFERDKSVSFRGQGYRLRLSSEGLQAVKDVVGPEEYERFYEICGKTSGGGMQKYNAVTGERMDDDAEQRIAPGTAQTIGIARGDLRKFLMEGCEDDIQWGKTVKSYELVEDGVFAVFADGEKSTKGSLLVAGDGISSTIAKQVSDGRLKVFDTGARGIHGQAPTTAFKDIGEGVFSFTDKRADNHTMSCITNVRSGDKDDPTKEFGFTIIASPGLIKAPGDNYSLVGEPAARLAQDLTSNWNKRFKPIFDQINVDQAAFWKITCSTETGVPEWDNVPRVTVIGDAAHSVTPAGGLGANTAMQDSALLGKLLAQNGGYADGITAEYEKEMRKYASEVVKKSYGLANESLGVGPLKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNP7</accession>
    <name>A0A1Y1UNP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_618682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873020.1">
        <property type="nucleotide sequence ID" value="XM_022015065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNP7"/>
    <dbReference type="FunCoup" id="A0A1Y1UNP7">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNP7"/>
    <dbReference type="GeneID" id="33556873"/>
    <dbReference type="InParanoid" id="A0A1Y1UNP7"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="50461" checksum="451C35DB284EE5E7" modified="2017-08-30" version="1">MKELNEHETAHDAPSAWQRAAWTRLFVSFMTFGLLNNVLYVIILSAALDLVPSTTPKGVVAFFNIFPALLAKVFWPILSRGTIRYARRVCLCTVCSWLGIAIIAFSSSVKPRLFGISLASLSSGLGELTFLQLSTTLPTPSSSRTALGAWSSGTGFAGIAGAGLWWLLRGLGVKGGLGLSSLLPLFFPLTYFVLLPSFSLLDEDAGAVYQPVPTDVGDSESTVSTYQPSEHPATSSSKKHKIQLTTMDKINLIKPLVLRFMLPLCIVYIEEYVINSGVAPTLVFPLPTTGLWSILFKSARDYYPFWSLTYQTFVFISRSSLSLGLPPLPRRLLPLPAIVQCGVLSLLSLQASKFVFSSPEYTPPAVPPLQGSDRTISFVFVLICLEGLCGGAAYVNTFYHVGREGEDGGEGLQGIRQKMEKEFRIGATGASDSLGILFASLISMPFELALCDAQVARGRTTCRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPC4</accession>
    <name>A0A1Y1UPC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_619648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873280.1">
        <property type="nucleotide sequence ID" value="XM_022015188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPC4"/>
    <dbReference type="FunCoup" id="A0A1Y1UPC4">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPC4"/>
    <dbReference type="GeneID" id="33556996"/>
    <dbReference type="InParanoid" id="A0A1Y1UPC4"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="192"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="363"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="472" mass="51603" checksum="A548FA56AC600E27" modified="2017-08-30" version="1">MSRPTLRDQLRALEDDDEASIDPENAYSSLDTVRIGQSNRDDYMDVGPSRLRGQLGDANQVLLGDKYAGTTVTRNKIFDDDEDEEQEGGGEDADSDDEEDESEDLRSEQDAEVEDHASGQRSGSEEDEGEDEESDGSNNDDEEEEEEDDDDDDEHDEDDPNSDPQPKASSSRLQASNSLDPVGALRAARAKDIERGRGIKRQKALFDGIVALRITFQKALAASNNILSTSPEHSQRKAEALDKLLALSDDLFELRKAILLPGTDTEEVADLGKRKRADASEDLLQASNDSLRLAEAQHSALVSILTKWYSKIQAATINVASKAAGSSKFLQSTKGQQSIVEVIQAGLSQAAGTTFMEHQEAGYRSLLREVIETRSVGGPDLSHLRREKKKKREAERGGSKGRKLRYTVHEKAQHFAVPVPLRDGWHEEQIDELFSSLLGGAGLQGAGTEGGVLSRDLGVDRGLTDLGGLRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPD7</accession>
    <name>A0A1Y1UPD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_648489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873654.1">
        <property type="nucleotide sequence ID" value="XM_022017849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPD7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPD7"/>
    <dbReference type="GeneID" id="33559658"/>
    <dbReference type="InParanoid" id="A0A1Y1UPD7"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012621075" evidence="2">
        <location>
            <begin position="24"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="59"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="290" mass="29869" checksum="E355416ABB148C55" modified="2017-08-30" version="1">MSKIPIFRYLFTVVTLFFTQSYAMPPPASMSAPAAAPSASVSSVGQSGGSGGGVYNQLIISYRDNLCLSIVGGNIASPKEGMAVQSLPCKSATTWNVNRGQTLITLAADVSLALDAKDLVDHGEVTLQKTSTNLPEQTWYFTNDNYIAVMNSTQCLDEGVNGVQLYTCQTNNDNQAWYVLPAENAPDPSMTYTDVTSTQSASVSTDTSLTISTGISTSSMASISVNTASAASLSASASAAPSGSATSQQLINGIQWNPFASDTRSGSIVSSAGASATSSATASGSISPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPI1</accession>
    <name>A0A1Y1UPI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_576189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873726.1">
        <property type="nucleotide sequence ID" value="XM_022013177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPI1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPI1"/>
    <dbReference type="GeneID" id="33554985"/>
    <dbReference type="InParanoid" id="A0A1Y1UPI1"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="3">
        <location>
            <begin position="184"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="409" mass="45400" checksum="F4F241BF89C667DD" modified="2017-08-30" version="1">MIPHRTIATTASAPDAMFSHPPPEPGSDFNVVMIGAGNIMFGSDEGPWNHSFRFEHKLGPRLKVVALIDPSTARADKVLEGKRQSFVESAYKDTKVFKTIEDYHASVQSKHSPTPHAIVVGCPPAYRGGTTKGTDLELHLIKLFPKTAYFIEKPVGTGTVKAAKEVTQELISNGNIVSVGYMLRYLRCVQKMKQIIHDNNLTIMATNARYSAAYEAIAKPAWWNKAIDMGPVIEQGTHFCDLSRYFGGDVDINTVNALSVEFYEKPGKLSKIPIDESKIPPELRIPRLTTAHWKYENGAVGSLTHAVALQGHAYACELEVWADGYHMRLVDPYQAPTLFVRRPGDDHEERHVYTDDDPFFSEVSSFIDAIEGGPDPHILSSFEDATKTYELTWAIRLASEASRAPMPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPY8</accession>
    <name>A0A1Y1UPY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_616435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873915.1">
        <property type="nucleotide sequence ID" value="XM_022014830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPY8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPY8"/>
    <dbReference type="GeneID" id="33556638"/>
    <dbReference type="InParanoid" id="A0A1Y1UPY8"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30097" checksum="9C02D129861C70D7" modified="2017-08-30" version="1">MAHEHPTNGVNGNGHVASDIASTFQRQGYYFAKGVFSPEELADLEVDFDRIVQQISSANEDINATWTGPEMKRLGGNDKVVLHTHNVQQYSAHWMKAFYHPKFLQVSKAILGEDIVLHHSKLFQKPSEKGAPFPMHQDWTYFPTIKDSMIAAIIHVSEATDEMGCLRVIPGSNEIGRMSNTSGQDQNDYLAAHPIESATPLPAQPGDVLFFHYFTLHGSMPNRSDKIRKTVLLQMYSGDDEVEAGNPHPNERLVLSGFNSKATRSIVNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ26</accession>
    <name>A0A1Y1UQ26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_576531</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873857.1">
        <property type="nucleotide sequence ID" value="XM_022013194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ26"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ26">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ26"/>
    <dbReference type="GeneID" id="33555002"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ26"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX40072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="59935" checksum="0C11ABB5DDEDCDC0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ53</accession>
    <name>A0A1Y1UQ53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_607253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873975.1">
        <property type="nucleotide sequence ID" value="XM_022014058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ53"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ53"/>
    <dbReference type="GeneID" id="33555866"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ53"/>
    <dbReference type="OrthoDB" id="2564927at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="858" mass="93760" checksum="6829E4D24CFDDA63" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ82</accession>
    <name>A0A1Y1UQ82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_229847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873512.1">
        <property type="nucleotide sequence ID" value="XM_022012231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ82"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ82"/>
    <dbReference type="GeneID" id="33554039"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ82"/>
    <dbReference type="OrthoDB" id="2591893at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41788" checksum="71885F827EE76607" modified="2017-08-30" version="1">MNKPKGHDIVHDALRYACLSLADADLAIKLKGRLKQHHATIYASSGDYWHQAVSQIQLAAELGMHLNDQDTGDVILAAVVILATRDRLAGWSEWEMPLSVGYRVLRELGGPDLYIASNPTRLRRFLVEQLVSIELLACLTAFKQPMIGDWYNHWLTEGGGDLEAVYGWDREAFLYGLRAITLCGDCVRLYILRTRCSDNPSKQVKELIETQIDNCKARISKFLDTSEAVRAMLQAIPNSAVRSRSICLQACVEICLLWILAEGNDTIEAKSMADRLSQRVEAIVQVADEAMARGDYAGMLLPLTWADGSVTPRQRELIMRLLNTLEANYHLDHESLWRITHIDWSAVEGFAPARWEEELRQMKIYFPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQA6</accession>
    <name>A0A1Y1UQA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_597098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873421.1">
        <property type="nucleotide sequence ID" value="XM_022013874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQA6"/>
    <dbReference type="FunCoup" id="A0A1Y1UQA6">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQA6"/>
    <dbReference type="GeneID" id="33555682"/>
    <dbReference type="InParanoid" id="A0A1Y1UQA6"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="75" mass="8597" checksum="A3DCF866E65F8954" modified="2017-08-30" version="1">MIIPVRCFSCGKVVGNLWESYVELLGAGVNEGEAMDKLGLKRYCCRRMVMTHVDLIEKLLQYNPFDKRDDMIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQD2</accession>
    <name>A0A1Y1UQD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_617037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874028.1">
        <property type="nucleotide sequence ID" value="XM_022014872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQD2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQD2"/>
    <dbReference type="GeneID" id="33556680"/>
    <dbReference type="InParanoid" id="A0A1Y1UQD2"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012305040" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="174" mass="17659" checksum="51DF26094E84E87E" modified="2017-08-30" version="1">MKYTLAAILTLAISAVAVQVTFPSETEGWETNGSQLVEWKSVSTDPTSCDIELTTPNNNTPTTIAKNVSVAEGSYIYTPSSPLQAGNGYRLNLVASGTISILAQSPQFNVTQGTSTVTPTSGMSQTSTSATHTSTTTSMSASASASHTSGAATHLTAPVSGLALLILGAVGAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQU3</accession>
    <name>A0A1Y1UQU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">10 TM acyl transferase domain found in Cas1p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_597559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873732.1">
        <property type="nucleotide sequence ID" value="XM_022013883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQU3"/>
    <dbReference type="GeneID" id="33555691"/>
    <dbReference type="InParanoid" id="A0A1Y1UQU3"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="759"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="391"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="921" mass="103097" checksum="CBD7905AB109B908" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR22</accession>
    <name>A0A1Y1UR22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative camp-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_640995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873671.1">
        <property type="nucleotide sequence ID" value="XM_022017386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR22"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR22"/>
    <dbReference type="GeneID" id="33559195"/>
    <dbReference type="InParanoid" id="A0A1Y1UR22"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000639">
        <property type="entry name" value="Related to serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="282"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="418" mass="47310" checksum="AE441541A22C56E0" modified="2017-08-30" version="1">MGAGCCKPEAIDFDGEVTLFHFYLLRSVGKGAFGKVRVVQHKQSKTLYALKYINKAKCVKMRAVANIVQERRLLEEIDHPFVVNLRYAFQDDENCFFVLDLMLGGDLRFHLDRTGSISEEVVRFYTAELALAIDYLHSKRIVHRDLKPDNVLLDERGHAHITDFNIAVHFSERRLLTGVAGSMAYMAPEVLTKRGYWAPVDLWSLGILAYELLFGKRPFRGRTNTALTNSILHEPLTWPDDAPTKCSSECMHAIRGLLERDPNKRLGYRGGLESIKTHPWFAGIDWEALYNKQVVPPFEPDSKKANFDATHELEELLLEENPLKARKRKEGQDVEQMSPEMRMMEEHFKVFDFSKGQRKSYYVQPPAGPPPSVFPSPSRPATPSDRIGIVSRSGLDVEGQIADGGGISKMRENGTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR33</accession>
    <name>A0A1Y1UR33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_616077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873832.1">
        <property type="nucleotide sequence ID" value="XM_022014787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR33"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR33"/>
    <dbReference type="GeneID" id="33556595"/>
    <dbReference type="InParanoid" id="A0A1Y1UR33"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="10" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
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    <feature type="chain" id="PRO_5012033515" description="ABC transporter domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1015"/>
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            <begin position="314"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
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    </evidence>
    <sequence length="1015" mass="107889" checksum="367AE257CD4E56C3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR91</accession>
    <name>A0A1Y1UR91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD324DRAFT_615861</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022014763.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0012507">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000139">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012734004" description="Small COPII coat GTPase SAR1" evidence="22">
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    </feature>
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            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    </feature>
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            <position position="29"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    </feature>
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        <ligand>
            <name>GTP</name>
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        <source>
            <dbReference type="RuleBase" id="RU003926"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORX39994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="189" mass="21458" checksum="4073F7DCD10FDF19" modified="2017-08-30" version="1">MWMLNWFWDILSQLGLTHKSAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHMQARRLWRDYFPEVDGIVFLVDSADTERFPESKVELDSLLGIESLATVPFLILGNKIDAVGAVSEEELRHQLGMFQTTGKGKIPLKDIRPIEVFMCSVVMRQGYGEGFRWLSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URM1</accession>
    <name>A0A1Y1URM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874369.1">
        <property type="nucleotide sequence ID" value="XM_022014307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URM1"/>
    <dbReference type="GeneID" id="33556115"/>
    <dbReference type="InParanoid" id="A0A1Y1URM1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="586"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="623" mass="71375" checksum="7E1BCEED060D1210" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URV6</accession>
    <name>A0A1Y1URV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_641114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873951.1">
        <property type="nucleotide sequence ID" value="XM_022017395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URV6"/>
    <dbReference type="FunCoup" id="A0A1Y1URV6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URV6"/>
    <dbReference type="GeneID" id="33559204"/>
    <dbReference type="InParanoid" id="A0A1Y1URV6"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05355">
        <property type="entry name" value="SDR_c1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="308" mass="33417" checksum="14692D5254C2A7C9" modified="2017-08-30" version="1">MGSDDKIITAFKELTNIKPQEQNLPGKDVNMDPYAEFTKLECWDDEGKPYLKEYQGSGKLKGKTAIVTGGDSGIGRAAAQMFAREGADVTIVYLPHEEEDAQRTKKAIEADGAKCLCVPFDLMKAENCKSVVDKHIEAYGKLDILVNNASKQIMEKDLADIDLENVESTFRSNILGMFALTKFALPHLKRGSSIINSSSVTAFKGSAAMTDYSSTKGAIVTFTRSLALQLAPKGIRVNAVCPGPVWTPLQPASRPSEQMEDFSVGTLPLHGRANMPSEMGPAYVFLASADSNAMTGQMMHLNNGQWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URY3</accession>
    <name>A0A1Y1URY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_575027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874472.1">
        <property type="nucleotide sequence ID" value="XM_022013099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URY3"/>
    <dbReference type="FunCoup" id="A0A1Y1URY3">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URY3"/>
    <dbReference type="GeneID" id="33554907"/>
    <dbReference type="InParanoid" id="A0A1Y1URY3"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="205"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="405"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="93369" checksum="C2E1AB3B190DAC21" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US02</accession>
    <name>A0A1Y1US02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_615701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873750.1">
        <property type="nucleotide sequence ID" value="XM_022014750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US02"/>
    <dbReference type="STRING" id="4999.A0A1Y1US02"/>
    <dbReference type="GeneID" id="33556558"/>
    <dbReference type="InParanoid" id="A0A1Y1US02"/>
    <dbReference type="OrthoDB" id="2574101at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012417714" evidence="3">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="218" mass="23538" checksum="80905AB9DECEF5E2" modified="2017-08-30" version="1">MLLSLALVALAGLLPSVSAYGYCGYGYYNDYDCNNGLSIGARIGIGIGIAVGVLLLFALCSYWRRKQLRRQFNKYRPPTLPFTNNNNSNNNNSSNPYANNPPPPAQAGSYYANGNQGSNWQNNQYGNNPPPPANVYQPSMAGAYGSGAKEMSSTGGRVTTPAAQGHEHGYEWEQAREAERQEREQANVQSPPGYDVASNTTGSTHYAPPSGPPPKRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US46</accession>
    <name>A0A1Y1US46_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 14">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_615910</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4 14"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873790.1">
        <property type="nucleotide sequence ID" value="XM_022014767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US46"/>
    <dbReference type="FunCoup" id="A0A1Y1US46">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US46"/>
    <dbReference type="GeneID" id="33556575"/>
    <dbReference type="InParanoid" id="A0A1Y1US46"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 14" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="16">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="17">
        <location>
            <begin position="245"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX40005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="403" mass="45246" checksum="D905ED88E71054AC" modified="2017-08-30" version="1">MTLSNGVNGTAHPTVTFEPNEHPHRRYNPLLGKHVLVSPHRTKRPWKGQTEAPVLTKLPAYDPECYLCPGNARSGGDRNPKYTETFVFENDFPALLSDPLPSMPDIHPSSDSSDSSNPTASFFESRPVRGRCKVICFHPRHDLTLARMDEEDIVHVVEGWRGIYEEEGAMLRSTGGGDEAEGHVQIFENRGAMMGASAPHPHGQVWSLSYVPDEPATTLYHLEKHAQTAPEPPADHPRGPDGRPSLLVSYAWEEVKRKERVVEIDEDSGWVAVVPFWATWPYEILLLPYKRHISSLCGLTPEETRGLAKVLKRVLVRFDNLFSCPFPYSMGIHQAPLPPLASKPDSSASIHFHFYPPLLRSASVRKFLVGFEMLGEAQRDLTPEQAAEKLRSVSDVHYLERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US79</accession>
    <name>A0A1Y1US79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_26100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874557.1">
        <property type="nucleotide sequence ID" value="XM_022012312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US79"/>
    <dbReference type="STRING" id="4999.A0A1Y1US79"/>
    <dbReference type="GeneID" id="33554120"/>
    <dbReference type="InParanoid" id="A0A1Y1US79"/>
    <dbReference type="OrthoDB" id="2576311at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="402" mass="43649" checksum="0C86C9FAA0A93F9E" modified="2017-08-30" version="1">MAGCMWCQLGNVSTWPDERDFSSQCDEYTFDGPGFAEAVQQIPLYAWKPWSGEQWAAAPASSSATLFISSTPTGTTTLSRSFPPATVTRTPTSTSPSSLTRSSSPSASATDASNDAPSSRTKWGSIIGGVVGGILAVILIFFLWRRHVRQKRQRDKEDLVIRYAPPKTSSSRGQSLLTFFGAAGFLDRSEKEKDAKRVTELMNDPKSFRSPRPAPKAPSIDDWRYTTTQDRMRARKADSDDSLSGQSGMSARQVLLEIHQSPIPTPGYSTDGRLLVHESQYDDDPLEGEDHQESNRGAWAGGSGPNAPLSTDFSQPRPFSASDVQTLPSLYEPQTGATRFTNTSLLTGDATQMSPDSRYPATEAGRGGSMIGETLGTGNRRAFGTSPPAPSHSQRPKKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USC1</accession>
    <name>A0A1Y1USC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase 1 beta subcomplex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_611113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874206.1">
        <property type="nucleotide sequence ID" value="XM_022014244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USC1"/>
    <dbReference type="STRING" id="4999.A0A1Y1USC1"/>
    <dbReference type="GeneID" id="33556052"/>
    <dbReference type="InParanoid" id="A0A1Y1USC1"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="65" mass="7576" checksum="C36B2FA24504A874" modified="2017-08-30" version="1">MPGPLYRDPWAAREAWRTQGVFDPKYMRRNMFPGLGIATVAFVAYVIYDDYLKPKVKHHAPAEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI3</accession>
    <name>A0A1Y1USI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_569244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874657.1">
        <property type="nucleotide sequence ID" value="XM_022013044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI3"/>
    <dbReference type="FunCoup" id="A0A1Y1USI3">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USI3"/>
    <dbReference type="GeneID" id="33554852"/>
    <dbReference type="InParanoid" id="A0A1Y1USI3"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001010">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="55"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="438"/>
            <end position="617"/>
        </location>
    </feature>
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        <location>
            <begin position="254"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
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            <end position="713"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="777" mass="82892" checksum="72C6AC77097B3737" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USJ6</accession>
    <name>A0A1Y1USJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_612763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022014438.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1USJ6">
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    </dbReference>
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    <dbReference type="GeneID" id="33556246"/>
    <dbReference type="InParanoid" id="A0A1Y1USJ6"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd06084">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
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        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="640"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="929"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1189" mass="126921" checksum="5F5D536E4FB4F4D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USW4</accession>
    <name>A0A1Y1USW4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_659672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874788.1">
        <property type="nucleotide sequence ID" value="XM_022018889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USW4"/>
    <dbReference type="STRING" id="4999.A0A1Y1USW4"/>
    <dbReference type="GeneID" id="33560698"/>
    <dbReference type="InParanoid" id="A0A1Y1USW4"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="373" mass="38575" checksum="7F66C52F8BCA12C2" modified="2017-08-30" version="1">MGPTSEFRAVPGSPRCRYFSSADLLLDPPQATMGTPMNQTSMSRLVSVNSIDDFCVFAPPEPNSVIGETEAEEVAWCIQQRNDARVIPDGTFQAIHFVKSPLYVQVMGWGDFTRINIQYGDEGGELDPHGATGLGNPVGGNVTSNITGQDVHYEEWMNYMAYNQFCIRICTAENSTYSAALECQHTLDEMGCEWVMPGDYTNNSFTSCDADAAYPPGLYPLANGSTSTFAQRYTGTYTNGAGSVGTFTVGETVTPQTPYSTPASSNCVTYSTIGNGIANVAIATEASNSTSASSTMTSGTASSASMTSTSSASGKSMSSGSGSASGSAKASGASSSTTSGAAMTRYAGINQGPAVAGACSVVALVLGAAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT16</accession>
    <name>A0A1Y1UT16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="8">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_575259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874353.1">
        <property type="nucleotide sequence ID" value="XM_022013118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT16"/>
    <dbReference type="FunCoup" id="A0A1Y1UT16">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT16"/>
    <dbReference type="GeneID" id="33554926"/>
    <dbReference type="InParanoid" id="A0A1Y1UT16"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 8" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="427" mass="47253" checksum="66447F4A505315CF" modified="2017-08-30" version="1">MSQKPWRRRHNPTPSTHTHTAIDILPTPELPSSSSRSSSLLSESNDPTSSSEQSPGQVSVPGAGDKLSFLSVYRAHMMIMTVHCILAVDFPVFPRRQGKCEDFGASLMDVGVGSFVFSLGLVSARKLVGSQVSNDNIFLKISQSIWKSLPTLVLGLVRVLMVKGSEYPEHVTEYGVHWNFFFTLAILPVIGISLRPVCQLVGWTQAGLLVAVLHQSALSSSGFNLQSWILSPDRNGLIEMNKEGLVSLPGYLAIYLLGVAIGQHVMRAAAPAKRVESATEKAEERIKRHYEQRRANLAMELVSFGLGWWSLLAFSRFMGVEVSRRMANSAYVLWVAGYNTLFLLGYLLLEIYLLEIPVPPHAVPPLLDAINRNGLMVFLIANLLTGVVNLSFKTMYLSNYQAMCILILYSIAVSAIAWTARYWKVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTB4</accession>
    <name>A0A1Y1UTB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_53264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874937.1">
        <property type="nucleotide sequence ID" value="XM_022013005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTB4"/>
    <dbReference type="GeneID" id="33554813"/>
    <dbReference type="InParanoid" id="A0A1Y1UTB4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="172" mass="19647" checksum="4BA6E42400626113" modified="2017-08-30" version="1">MTWKEYYLRCTSQLYHDRVWHVVFSLAISDRHPCAQVLLYKRSVYSHPTSSFLFLSIRFFFPPSVPSTHTLLDPTLVGSQQSHSRSTDTLRFHLDHSYTTPPCRSLSLAALAMPLLPDPLPLLLESSSETPSTQLHYASFRHIHIPSFRPCVNEFDQNSSVSLLSLDTRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTJ8</accession>
    <name>A0A1Y1UTJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exocyst complex component Sec10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_611086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874194.1">
        <property type="nucleotide sequence ID" value="XM_022014242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTJ8"/>
    <dbReference type="FunCoup" id="A0A1Y1UTJ8">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTJ8"/>
    <dbReference type="GeneID" id="33556050"/>
    <dbReference type="InParanoid" id="A0A1Y1UTJ8"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="916" mass="102063" checksum="20D529BB31564D14" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTQ3</accession>
    <name>A0A1Y1UTQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_585883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874485.1">
        <property type="nucleotide sequence ID" value="XM_022013739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTQ3"/>
    <dbReference type="FunCoup" id="A0A1Y1UTQ3">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTQ3"/>
    <dbReference type="GeneID" id="33555547"/>
    <dbReference type="InParanoid" id="A0A1Y1UTQ3"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="307"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="516"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="683" mass="74274" checksum="69EC9DE4D2BB8FEC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5Z6</accession>
    <name>A0A1Y1U5Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_585136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867784.1">
        <property type="nucleotide sequence ID" value="XM_022013720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5Z6"/>
    <dbReference type="FunCoup" id="A0A1Y1U5Z6">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5Z6"/>
    <dbReference type="GeneID" id="33555528"/>
    <dbReference type="InParanoid" id="A0A1Y1U5Z6"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="146"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="457" mass="50881" checksum="AFF7855E5A10790D" modified="2017-08-30" version="1">MLPSCTRCSLPATIRTVLKSASGLTASDPASDPASMSTLKGWIKSIRGHKNVSFISISDGSTYEPLQAVYRGVLGPEYSIGASVQLTGKLQPSRGRQEVEFLISKSSVLGPCDTMEYPIQKKNLPTKVLRDHAHLRFRTTQTTALMHLRDGILRDWHDWFESNAFTYIHTPVLTSSDCEGAGETFSLSSNVFPDRVNLTVSSQLHLEAPTHAVSRTYTLSPCFRAEPSATPRHLAEFYMLEGEVVVDTLDGLMDVVEDGIKSTLKSMLRGTTDRSERLRDALLAIRSSDVVRDTMADLNTTMYEPFARMTYAKAIKILTKHHAVTPFNHPPIPGHGLSLEHEKHLAADRPIFITHYPAAIKPFYMLPADNDTVACFDLLLPSLGEIAGGSLREHRLSHLEASLPSEEYAWYADLRRYGSIPHGGWGMGWDRWISWITGVDNVKDVVAFPRWVGHCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6M8</accession>
    <name>A0A1Y1U6M8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_639049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867962.1">
        <property type="nucleotide sequence ID" value="XM_022017186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6M8"/>
    <dbReference type="FunCoup" id="A0A1Y1U6M8">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6M8"/>
    <dbReference type="GeneID" id="33558995"/>
    <dbReference type="InParanoid" id="A0A1Y1U6M8"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="510" mass="56177" checksum="CB90DEB2640D04C7" modified="2017-08-30" version="1">MSDLASVKAAVKAWERSFKATHKRDPTKEDIKNDPGRIGEQYALYRKLSKLSSESQRSSSSGSQRPDSFRIVPSNGYPTTPTPPTRHRSVSRSSSRPTASSVEANRCLPSSQAGPSTPSRLITPKKSRPYSGPIHDPNPINPFAVTPVKTPASHLGSAGMFSTDRTASSSSPFIHASSPRKLRQVLEANSLRKVREREGLEEITPRTRARKRLRGEAVADTPVKDRPVRRKRGERRPTTEASSDAVSKGKGKLPLEDEFGPSPMRPEVDKTFTALFDEPDEGSEVVGLEDIRSRSSVMMGLFGRATVEIKKKPQIGEESPAPSLPLPVTEAAETVVIDAEELAHTPQRPCKVISFSDDEQDEWDPEGGHVTHQVVITGTRRQVCKPRDSLSDGTDGDDDGLDTPELYDNITEETSHTSIHPSSPPPLLSLLSIQSPRAKTTITEMRYKAIFDPSQAARLRAMKRGQEVYISGQGVDRDGDMEEENEVEGDDDWEEEPEGWKEAGIADEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Q4</accession>
    <name>A0A1Y1U6Q4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_638332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868019.1">
        <property type="nucleotide sequence ID" value="XM_022017102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Q4"/>
    <dbReference type="FunCoup" id="A0A1Y1U6Q4">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6Q4"/>
    <dbReference type="GeneID" id="33558911"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Q4"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="358" mass="40905" checksum="6DB162271675E9E3" modified="2017-08-30" version="1">MSLWVDKYRPRTLDELHYHDQLSARLRSLAASGDFPHILFYGPSGAGKKTRIMCTLRELYGPGVEKLRIDQRVFVTPSNRKLDVNVVQSNYHIELTPSDVGMYDRVVIQDILKEIAQTQQVDLNAKQRFKVVIINEADALTRDAQAALRRTMEKYMNNMRLILCAGSTSKIIAPIRSRCLLVRVAAPTDDEMSKVLHHVAKKERFHLPDPASDAIISSSSGNLRKALLVFEAMKMQRPDLSGDLDVAKPDWETYCGKVADAILSEQSAQKLLEIRGKLYELLSHCIPPTVVMKTISERLVEKVDDEVKKQIVHWTAYYELRMRVGSKKIFHLEAFVAKIMMVYKNYTLMGMMDDIDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6V4</accession>
    <name>A0A1Y1U6V4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000036">
        <property type="protein sequence ID" value="ORX33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867599.1">
        <property type="nucleotide sequence ID" value="XM_022018788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6V4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6V4"/>
    <dbReference type="GeneID" id="33560597"/>
    <dbReference type="InParanoid" id="A0A1Y1U6V4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="30407" checksum="07CBB307FFE4783B" modified="2017-08-30" version="1">MVDGVSDEDSLVAWELFLSAYSKGEYLHSCPDIPPLPPRLREMLEHPELAQYGKDNPHTPLFPSTYIDRETARIARDFFCAHGYLPPPRPTTEKSREACVLEYDLLSESQLTNIQEAVDILSGFFPGALISFSLFYKRVQQYYAFAGPQEYIDLFSLCKGGAIPVEDSLCAHAVLSAGKTVFIPDAKKDWRYRYNPYVLRGMEAYIGSPVRLSEDPTRPEAELITIGTLNVCFMNKTVEQVLGREEQAISTRRNKGRTSKNSDRKFSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U718</accession>
    <name>A0A1Y1U718_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000026">
        <property type="protein sequence ID" value="ORX33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867667.1">
        <property type="nucleotide sequence ID" value="XM_022017323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U718"/>
    <dbReference type="STRING" id="4999.A0A1Y1U718"/>
    <dbReference type="GeneID" id="33559132"/>
    <dbReference type="InParanoid" id="A0A1Y1U718"/>
    <dbReference type="OrthoDB" id="3182995at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="80122" checksum="610C20FB301ED51E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U760</accession>
    <name>A0A1Y1U760_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_584515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868160.1">
        <property type="nucleotide sequence ID" value="XM_022013685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U760"/>
    <dbReference type="FunCoup" id="A0A1Y1U760">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U760"/>
    <dbReference type="GeneID" id="33555493"/>
    <dbReference type="InParanoid" id="A0A1Y1U760"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="773" mass="85818" checksum="B0E4EB6DA05E8C56" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U798</accession>
    <name>A0A1Y1U798_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Thiamin diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_637656</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868188.1">
        <property type="nucleotide sequence ID" value="XM_022017029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U798"/>
    <dbReference type="FunCoup" id="A0A1Y1U798">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U798"/>
    <dbReference type="GeneID" id="33558838"/>
    <dbReference type="InParanoid" id="A0A1Y1U798"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="239"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="448"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="615" mass="67478" checksum="412ADE12E5DCF5EB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7B7</accession>
    <name>A0A1Y1U7B7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EXS family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_594834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868207.1">
        <property type="nucleotide sequence ID" value="XM_022013837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7B7"/>
    <dbReference type="FunCoup" id="A0A1Y1U7B7">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7B7"/>
    <dbReference type="GeneID" id="33555645"/>
    <dbReference type="InParanoid" id="A0A1Y1U7B7"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="226"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="517" mass="58227" checksum="A64C684609452F58" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Q3</accession>
    <name>A0A1Y1U7Q3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FYVE zinc finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_638238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868349.1">
        <property type="nucleotide sequence ID" value="XM_022017092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Q3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Q3"/>
    <dbReference type="GeneID" id="33558901"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Q3"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="899" mass="94347" checksum="F40C2BBFB1C9F52A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7R9</accession>
    <name>A0A1Y1U7R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868368.1">
        <property type="nucleotide sequence ID" value="XM_022018702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7R9"/>
    <dbReference type="FunCoup" id="A0A1Y1U7R9">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7R9"/>
    <dbReference type="GeneID" id="33560511"/>
    <dbReference type="InParanoid" id="A0A1Y1U7R9"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="535" mass="61447" checksum="6F8D55DCBE58A2FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7W1</accession>
    <name>A0A1Y1U7W1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868399.1">
        <property type="nucleotide sequence ID" value="XM_022016926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7W1"/>
    <dbReference type="GeneID" id="33558735"/>
    <dbReference type="InParanoid" id="A0A1Y1U7W1"/>
    <dbReference type="OrthoDB" id="2596052at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="889" mass="97167" checksum="6EA71B1B85DB5174" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U845</accession>
    <name>A0A1Y1U845_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_583988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868461.1">
        <property type="nucleotide sequence ID" value="XM_022013650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U845"/>
    <dbReference type="FunCoup" id="A0A1Y1U845">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U845"/>
    <dbReference type="GeneID" id="33555458"/>
    <dbReference type="InParanoid" id="A0A1Y1U845"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="41794" checksum="26804FAB8E442CB2" modified="2017-08-30" version="1">MEIIKPKKNAVLDVVDNVDDTDGYYRITPGEILDDGRYQVTITLGKGMFSAVVKAKVLKAVGQERRQDVVGREVAIKVIRSQEAMYSVGRKEVAILKQLNDADPDDKKHIVRLEHVFDHRGHMCLVTESMSMNLRDVIKRFGKDVGLNMRAVRAYAHQLFLSLSLMKKCNIVHADIKPDNILASENKGLLKVCDFGSASDASEGEITPYLVSRFYRAPEIILGLPYDTAIDIWSVGCTLYELYTGKILFPGRSNNHMLLLMMETKGKISHRHIKKATFRDMHFDESNDFISIETDKITGQAVAKTLVISKPTRDLRSRLVPPSSVQLKMKDDELKQLLHFVDLLEKCTQLDASRRITPREALLHPFLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U862</accession>
    <name>A0A1Y1U862_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GS catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_654254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000027">
        <property type="protein sequence ID" value="ORX33305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867656.1">
        <property type="nucleotide sequence ID" value="XM_022018777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U862"/>
    <dbReference type="STRING" id="4999.A0A1Y1U862"/>
    <dbReference type="GeneID" id="33560586"/>
    <dbReference type="InParanoid" id="A0A1Y1U862"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="112"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="384" mass="41964" checksum="789527C7100B8D15" modified="2017-08-30" version="1">MDDFLARHPGVKYIVYLTVDYGNVARCLLTTTSRARHIAATHGSVASASSMQFASWAITGTDDDVEQILEGSAHWRPHWETLRLAHRVDQAIVMCSLEEIKAGPAHELDRDPRTVLQRVIDEARREDGIECMVGYEIEFHLLDGPGPSGPNEGAYSMSVVREARFDVVLEMVDAIERAGISTWAIHPEVNKDEYEISLAPRDALGAVDDLIHAQNIIRGIARRHDLVATMHPQRAEQGPTIGNHTHISVNKCGDAFLAGLVEGLEGISAILMGGYDSFGGGRNAMLGDGKIGWSESKSTPIRRFSENHFENRVPDCLANPYLQLAALIGTGMEGVRGVGGGRRRSSLGQDHGTLPMGQASALDLLERNETMRRILGSAFETQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U881</accession>
    <name>A0A1Y1U881_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_638450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868053.1">
        <property type="nucleotide sequence ID" value="XM_022017115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U881"/>
    <dbReference type="STRING" id="4999.A0A1Y1U881"/>
    <dbReference type="GeneID" id="33558924"/>
    <dbReference type="InParanoid" id="A0A1Y1U881"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801857" description="Protein YTP1-like C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="33"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="149"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52946" checksum="24FA0630AD8CB25F" modified="2017-08-30" version="1">MAWRSLAFLLVCSVLRAVRAHEHHHDLSEIDLTIGFDWMIWTHMVIQAFVWGISFPLGMVLGMTKSKYHVPLQSTNVVLVFIAMWMGHHHGGREFPATVHGIMAKIIWWIMILQASMGIFLKFHVMEKTVRRYVVPVHGVLGKSFPVLGWTQMVFGAATALNFCRGGELGQCAAHYIMGSAFIGYAVILVIMLQLGGRWLAKVGCSQEMLDSSVITAWGIVNAFTEHHGGPWTHKDMQHTMLGVLWWAGGMLGIFLSRGGKRSFVPAVIIIMTGWGMSAHEQALMISSKIHGLFGYALIAAGVLRIVEVCFVLNDGPTPPGIVRVFQQLPPYLLVLGGVLFMSATDEEMHHADNLGIDHVSYALFDFSLSFLIYLVITFMVHMYQTTGQNALSAEEAANHPEGQESGYAKLRQRNVSQDDGPDGPEAYELAEQDDPVVFESVRGGQVNGHPPEMDERDEVDWLHKDTRNENRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8A3</accession>
    <name>A0A1Y1U8A3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000024">
        <property type="protein sequence ID" value="ORX33345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867692.1">
        <property type="nucleotide sequence ID" value="XM_022017313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8A3"/>
    <dbReference type="GeneID" id="33559122"/>
    <dbReference type="InParanoid" id="A0A1Y1U8A3"/>
    <dbReference type="OrthoDB" id="10663028at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="310" mass="34700" checksum="3E0C0E06B5CF5B13" modified="2017-08-30" version="1">MDGSDSETDQPTLRPGYRGHITLDNLSLDETSALGSDDGQRSKDLGASDSSVINPSTSTDDQVTSSFQDHDDSVDDDISVELHRLSLRAAVSSFHGQGQEGESILYNDMDMGTVLSLRAEDAPPIPFSSRTPASPTPFTSDRSEPTPAAFRNQRSKSRMPSNVVSASHDNQKDMLTAINARLECLVRCAKQPEFENRLRELDEDLHILLPSIREARPHPSTRQHWHNRGGFFLDLPLAYFLHHRHMVIAGKDVNIQQLKDYLEMARTYKNTMSTVAAFQAQYGETITWRPRDGSVGIWAKQQRKQNHSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8N6</accession>
    <name>A0A1Y1U8N6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_635737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868672.1">
        <property type="nucleotide sequence ID" value="XM_022016838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8N6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8N6"/>
    <dbReference type="GeneID" id="33558647"/>
    <dbReference type="InParanoid" id="A0A1Y1U8N6"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011002841" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="816"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111877" checksum="DC7647789B47D617" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9L1</accession>
    <name>A0A1Y1U9L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_582971</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868962.1">
        <property type="nucleotide sequence ID" value="XM_022013589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9L1"/>
    <dbReference type="FunCoup" id="A0A1Y1U9L1">
        <property type="interactions" value="724"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9L1"/>
    <dbReference type="GeneID" id="33555397"/>
    <dbReference type="InParanoid" id="A0A1Y1U9L1"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="93"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="755"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="816" mass="89900" checksum="441869F3B949A0D3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9R9</accession>
    <name>A0A1Y1U9R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_175038</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868534.1">
        <property type="nucleotide sequence ID" value="XM_022012098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9R9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9R9"/>
    <dbReference type="GeneID" id="33553906"/>
    <dbReference type="InParanoid" id="A0A1Y1U9R9"/>
    <dbReference type="OrthoDB" id="2587207at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002146">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="85"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="308"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="863" mass="95973" checksum="9EBBF6252A3C584A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Y0</accession>
    <name>A0A1Y1U9Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_635222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869075.1">
        <property type="nucleotide sequence ID" value="XM_022016796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Y0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Y0"/>
    <dbReference type="GeneID" id="33558605"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Y0"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="170"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="583" mass="63101" checksum="AD7C45420CCD279E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA07</accession>
    <name>A0A1Y1UA07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_183214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868203.1">
        <property type="nucleotide sequence ID" value="XM_022012118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA07"/>
    <dbReference type="GeneID" id="33553926"/>
    <dbReference type="InParanoid" id="A0A1Y1UA07"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="143" mass="15758" checksum="8BEF15580B8B9B6F" modified="2017-08-30" version="1">MSPILKRDISEHARQARKLASVLTGERAPSPEGSWNNEPSSSTLVSLDSPRIEPGNGSIATGRKINEILDRDRHVTDLNKEEDSGQVLGRVESDEHQRMLQSPWSGQVERMGFLDAHDDGLNTSWKAQGGQWADLKSLLMGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAC3</accession>
    <name>A0A1Y1UAC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_150936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868709.1">
        <property type="nucleotide sequence ID" value="XM_022012025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAC3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAC3"/>
    <dbReference type="GeneID" id="33553833"/>
    <dbReference type="InParanoid" id="A0A1Y1UAC3"/>
    <dbReference type="OrthoDB" id="2583551at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF215">
        <property type="entry name" value="DYNAMIN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="65"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="682"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="769" mass="86304" checksum="77E37AA6E127B132" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB16</accession>
    <name>A0A1Y1UB16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_631915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869420.1">
        <property type="nucleotide sequence ID" value="XM_022016477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB16"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB16"/>
    <dbReference type="GeneID" id="33558286"/>
    <dbReference type="InParanoid" id="A0A1Y1UB16"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="78"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="28458" checksum="C3D9D5F545D65BA6" modified="2017-08-30" version="1">MLRLHHRLVPLLSSSLSSTSSYSLQRPILSCTPLDQGHPLSTRNMSSRSSAENTSAKDIPTLHDLYAKDELQNSEEEDPVNSADEKLNSRISIWRGNIVHLQADMVVNAANKSLLGGGGVDGAIHRAAGPELLKECEGLGRAETGETKVTQGYRLPAKRVAHTVGPVYAKTKVDEKAAQLESCYRTSLELCAEHGGGVIGFSSISTGIYGYPIVDATRIALQTTRKFLETNENVTRVIYVTFSERDKGVYESLAPIYFPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB68</accession>
    <name>A0A1Y1UB68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_634803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868988.1">
        <property type="nucleotide sequence ID" value="XM_022016759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB68"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB68"/>
    <dbReference type="GeneID" id="33558568"/>
    <dbReference type="InParanoid" id="A0A1Y1UB68"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="5">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="420" mass="45075" checksum="BBFE62220474D142" modified="2017-08-30" version="1">MSISPPSSLLHLSRPSSLRPTPSTRRHRSSSIHSSGVENMSMSSSGSSSTSFRRFSLTDPTATAAPAPAASFSSSAASSSSSSHSSSSSRPLHPMSFSQISLHLPDSDGDQRACVAKRGSHTSTDILSTLAEGSVGLAVPRDRWQPDCSSALCSFPCCTALFAPPENRSYFALYRRRHHCRLCGLLFCADHTTQRAPVTVTDANGAQSIVSERVCDVCIPPPRDGGAGLSGQPSRRGSQTSSVTDSNRLSETILTPSEEVPILNASLVCSQVSSPVHASPEQLAPIQSWMDASGILSLYPLAVNASHSGRPPSNPSAPPLFTRRDKSPVQTLHQRRQAKHAELWIPEKWGYKREQFDVTYHQDFDGDSDAEEPAGGIVEDGPFRYRAPAKRAVNPARTPTLSRQSSVGELSKAPRVHVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB99</accession>
    <name>A0A1Y1UB99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_632304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869503.1">
        <property type="nucleotide sequence ID" value="XM_022016507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB99"/>
    <dbReference type="FunCoup" id="A0A1Y1UB99">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB99"/>
    <dbReference type="GeneID" id="33558316"/>
    <dbReference type="InParanoid" id="A0A1Y1UB99"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="40315" checksum="274BE609E5E5C75B" modified="2017-08-30" version="1">MAPRKSRSVKSSAPSPSPAVSSRASSRSRSKSKRQSTDDTDVIPEEEDVNLEHSGEEEEADEEDNEEAKGGASDTIVEEDGEEHEQGAEEPAVGDGVGEVDERQEDSDVKGKGKMSMQDRMAKLKDLRMRMNKSSADNRKDLIADHQKSKVTAKELQRLEKQRKLAQTLRLKAEAEENGEDLERKKAWEWSIEQNERWEAKMEESKRRSDTLFHNADDDAHKRYDKNIRTTKIDLVAYERQKEAALGLAPGTLVPAGATASSLKASSSSSRGLTAAEDLYRGADTLAYGDSKPSEDAIDRVVGKINSDMSKVKRKKKDDVDEEITYINERNKVFNKKISRYFDKYTKEIRSNLERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBK2</accession>
    <name>A0A1Y1UBK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_603494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869572.1">
        <property type="nucleotide sequence ID" value="XM_022013961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBK2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBK2"/>
    <dbReference type="GeneID" id="33555769"/>
    <dbReference type="InParanoid" id="A0A1Y1UBK2"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="536" mass="59658" checksum="1C4E076612B89695" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBK4</accession>
    <name>A0A1Y1UBK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869589.1">
        <property type="nucleotide sequence ID" value="XM_022016541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBK4"/>
    <dbReference type="FunCoup" id="A0A1Y1UBK4">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBK4"/>
    <dbReference type="GeneID" id="33558350"/>
    <dbReference type="InParanoid" id="A0A1Y1UBK4"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="302"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="553" mass="61453" checksum="5651D96D5B065FC2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBS6</accession>
    <name>A0A1Y1UBS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_609642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869642.1">
        <property type="nucleotide sequence ID" value="XM_022014162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBS6"/>
    <dbReference type="FunCoup" id="A0A1Y1UBS6">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBS6"/>
    <dbReference type="GeneID" id="33555970"/>
    <dbReference type="InParanoid" id="A0A1Y1UBS6"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="162"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="458"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="785" mass="85898" checksum="35706F651E68F611" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBZ9</accession>
    <name>A0A1Y1UBZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_652085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869696.1">
        <property type="nucleotide sequence ID" value="XM_022018438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBZ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBZ9"/>
    <dbReference type="GeneID" id="33560247"/>
    <dbReference type="InParanoid" id="A0A1Y1UBZ9"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="44"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="548" mass="60048" checksum="E531ADE873C7061A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC07</accession>
    <name>A0A1Y1UC07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869232.1">
        <property type="nucleotide sequence ID" value="XM_022018544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC07"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC07"/>
    <dbReference type="GeneID" id="33560353"/>
    <dbReference type="InParanoid" id="A0A1Y1UC07"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="424" mass="46276" checksum="CAD6C4DF07DA419D" modified="2017-08-30" version="1">MAAFPQTFTSTVSHWQATNRGPDALYGHGKTDSLPTGVVDYVIIGAGLSGASLAYHLSRPGVCDDKRIVVLEGKDVASGATGRNGGHIAPYSFASLSGFTRPLEAGGSGLTMDDALDIMKMEVRNLDLVTEIVMREKWDVDLWRGEKLEVVDTLEEKEVMDTSYEVWIEALKTRRDVPDWDWVTDEAEANRVSRHPKAIAFSRGKAGSVHSHKLCTAFMKSALASGRVDLFSWCPVQSIDKGPNEGWNVQCHERGVVRANEVIVCTNGYTRNLFKNHPISDHLSPYRGHATQVTPTLPYSGPGALKHTLCIENGPYLIFTPSSGWVFGVGYADIIRQKAGTHDDVMGATDDGIVPEGIKQWLASYCKEEFEGWGEEAPGEGAQRFWSGIQCASRDRLPLVGQVPGSPGLEEAVGVWEPSDPVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC22</accession>
    <name>A0A1Y1UC22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_633847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869300.1">
        <property type="nucleotide sequence ID" value="XM_022016668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC22"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC22"/>
    <dbReference type="GeneID" id="33558477"/>
    <dbReference type="InParanoid" id="A0A1Y1UC22"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276:SF0">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="174" mass="18356" checksum="51578D7DFEFA645E" modified="2017-08-30" version="1">MSQPSQADIFAALQAQSSSSRKRPPTQLISDLPEGEDAKASLTNGQGTNVTKIHCFRQGCGCVILAPGVGQWISADSNLIPSEDGSPFPGSNASPDNQSAYWHITGSPMSFDNIGFSKPSELKSLSLNAPGNASGKKVKWLSCADCDLGPVGWSFEGGTEAWLAVERVRYGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC25</accession>
    <name>A0A1Y1UC25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin associated protein KTI12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_583192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868877.1">
        <property type="nucleotide sequence ID" value="XM_022013601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC25"/>
    <dbReference type="FunCoup" id="A0A1Y1UC25">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC25"/>
    <dbReference type="GeneID" id="33555409"/>
    <dbReference type="InParanoid" id="A0A1Y1UC25"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000827">
        <property type="entry name" value="KTI12 chromatin-associated homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="282" mass="31354" checksum="425AF1FC93CC12A3" modified="2017-08-30" version="1">MALVTIAGYPCSGKSRIARMLADDFRARLQSSEYDGPKFEVVVVDDDSSHVPRSVYDDSKVEKSGRANLFSNVTRSLGQETITICDSLNYIKGFRYQMYCAAREASCRVCTVYVATPPERCTEWHEERGECSYKSTTFENLIMRFEEPSSMVRWDSPLVTISPDEEPPLEEIWNIVTKGEKKGPNAARPKPPPNTLLILTNTTHTITTSLLAHLNAGPATSTYIVPCPPAASAGSLTLHLPMRRVTLPEMQRLKRQAAGSWSESEVASAFVRFLETVWATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCB3</accession>
    <name>A0A1Y1UCB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_631119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869845.1">
        <property type="nucleotide sequence ID" value="XM_022016408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCB3"/>
    <dbReference type="GeneID" id="33558217"/>
    <dbReference type="InParanoid" id="A0A1Y1UCB3"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="346" mass="38501" checksum="4AFAF6249ACB91CC" modified="2017-08-30" version="1">MSAPPGDEDFTELSPSQAFRPRNPGVVRTPPGGHKPLPSQSTSSATPAAPVATAPEAMETDDAGTRQASSSRTPLKANQANTFETPGQGNEGEAGPSQDMDVEATRTPRSTRKNRPSAQKPMEDVSGMDLEGDESIEEGEYGRRWRKTMETLELATKAAAQKWTAKDLKQSFPSLAEDDSGEMDAIWLQAAQTMRERLLELGMDVMKHYKVPSSLQQIDQVVKEGETYAQEHRKDKHGRRDAWRPDITPEILTAATQLPLYDETHARIRDEYVLLHEDCRKRYLSILEKQARLDEMEGGVAEGIAELEKTISLLGGFPSEEMMVWMEESSAMTAGVRDQRRRQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCL3</accession>
    <name>A0A1Y1UCL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_581609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869906.1">
        <property type="nucleotide sequence ID" value="XM_022013516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCL3"/>
    <dbReference type="FunCoup" id="A0A1Y1UCL3">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCL3"/>
    <dbReference type="GeneID" id="33555324"/>
    <dbReference type="InParanoid" id="A0A1Y1UCL3"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="90" mass="10625" checksum="764590D80A3DB1E7" modified="2017-08-30" version="1">MIEVIANDRMGRKVRVKCLPTDTVGDLKKLIAAQTGTTAQKIQLKKWQVHPARWRLTRRRYTSFKDHVSLRDYEINDGMVRRLETPLELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCW3</accession>
    <name>A0A1Y1UCW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase of plants and bacteria-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_581435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870020.1">
        <property type="nucleotide sequence ID" value="XM_022013504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCW3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCW3"/>
    <dbReference type="GeneID" id="33555312"/>
    <dbReference type="InParanoid" id="A0A1Y1UCW3"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="306" mass="33951" checksum="1EC71DFA2C5DE058" modified="2017-08-30" version="1">MSFLTPPSHSPFQPLQPVQTPTNPPAGSLIITLVHPDPSRSPATAFFLLCVPDPCLFAYYSALFIHRHFTSSSSTGPIRWRHQHIELELEDKDGLAATSGGRIGISLHWIGNVMKDVNEGRRTMDSAAQEFKGVILHEMVHTIQHDGFGSTPGWLIEGFADYVRLLARLDPPHWKKAGQGNPDKGYETGYDVVAWFLCYLTGQEPPSVPYTGPDAYIPVNFAIPPPVTTQTPSQALPTRIAQDGQPNSPPPPGPPASRPRPRGPFPGLVHVIDSRLETSRWSDSWWVEMTGAPLDVLWREYLEYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCX6</accession>
    <name>A0A1Y1UCX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="5">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_94220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869574.1">
        <property type="nucleotide sequence ID" value="XM_022019285.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UCX6">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCX6"/>
    <dbReference type="GeneID" id="33561094"/>
    <dbReference type="InParanoid" id="A0A1Y1UCX6"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000004">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.480.20:FF:000012">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein,Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01540">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011786">
        <property type="entry name" value="CysI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02041">
        <property type="entry name" value="CysI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="627"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1362" mass="148077" checksum="1A6AB4CB209A7167" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCY3</accession>
    <name>A0A1Y1UCY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870012.1">
        <property type="nucleotide sequence ID" value="XM_022018394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCY3"/>
    <dbReference type="GeneID" id="33560203"/>
    <dbReference type="InParanoid" id="A0A1Y1UCY3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="82" mass="9321" checksum="3BEAD40746E1FD9F" modified="2017-08-30" version="1">MLIPKDQPVPPAQQGNSKQMDKIQATKQHIDEATAEFSKTIEAIHERGERLEDLRGQERSLEYPKSEFQGQGKSSQEKDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD58</accession>
    <name>A0A1Y1UD58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_514319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870099.1">
        <property type="nucleotide sequence ID" value="XM_022012971.1"/>
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        <property type="interactions" value="748"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005730">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
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        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="462"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="747"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1288" mass="139828" checksum="A19AF11F1C23A09A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD79</accession>
    <name>A0A1Y1UD79_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_643074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022017525.1"/>
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    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="517" mass="56982" checksum="7FE088B97625ABA3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDB3</accession>
    <name>A0A1Y1UDB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869281.1">
        <property type="nucleotide sequence ID" value="XM_022018551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDB3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDB3"/>
    <dbReference type="GeneID" id="33560360"/>
    <dbReference type="InParanoid" id="A0A1Y1UDB3"/>
    <dbReference type="OrthoDB" id="2576380at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012734000" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="57080" checksum="468D5EAA49B61829" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDC1</accession>
    <name>A0A1Y1UDC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_609780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869291.1">
        <property type="nucleotide sequence ID" value="XM_022014173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDC1"/>
    <dbReference type="FunCoup" id="A0A1Y1UDC1">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDC1"/>
    <dbReference type="GeneID" id="33555981"/>
    <dbReference type="InParanoid" id="A0A1Y1UDC1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="47"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="376" mass="40251" checksum="50ECB869B3827207" modified="2017-08-30" version="1">MMRSAVKSLSNPLRSTSVFPRTFATSAISSTPTSAFSAKKGSNGNYTVTMIPGDGIGPEIAESVKSIFKAAKAPIDWEEVDVTPVLVNGKTAIPQDAIDSIKKNTVALKGPLATPIGKGHVSLNLTLRRTFSLFANVRPCVSIKGYKTAYDNVNTVLIRENTEGEYSGIEHEIVDGVVQSIKLITYEASERVARYAFHYAQENGRGEVTAVHKAPIMKMSDGMFLTACRAVAKEYPKVKYTEDLLDRVCLRIATDPSPFAERVMVMPNLYGDILSDLSAGLIGGLGLTPSGNIGKDASIFEAVHGSAPDIAGKGLANPTALLLSSLMMLRHMNLHSHADTIEKAALSTIAEGKHITRDLGGKAGTKEYTDAILARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDJ6</accession>
    <name>A0A1Y1UDJ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_581495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870232.1">
        <property type="nucleotide sequence ID" value="XM_022013508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDJ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDJ6"/>
    <dbReference type="GeneID" id="33555316"/>
    <dbReference type="InParanoid" id="A0A1Y1UDJ6"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="485" mass="51702" checksum="044BBBF578710E3A" modified="2017-08-30" version="1" fragment="single">AYAPQLASKLDLSSTEINLIGVAGNFGMYLTGPLWGKFVDSRGQQMQLTGQRPLLCSSIVIFTGYFLVHSFYSGALPIRPDSSHHPTTIGLLGLAFAMFLSGSGGAGGLSAAVNAAAKSFSDQTRATASGLVLAGFGLSAFAFSTLGHVIFGGDAGGLLLLLSFGTGIPIFLGSFIVRAVPPATANGYEPVSALEEGEGYVSRNTSVELSRSRSPRPRHRHAEPEDGKAPLRAGHSYTPFELLFTSDFWIIGVILALLCGTGLMYINNVGSVALALTREGKVDYDPRVVSAWQAKQVATVSIWNCMGRIIGGIYSDFCKTRFGMERIWFLPVVAGLFIISQLSALNTTVVSNLWIVSTLLGLAYGSLFNVVPMLVLEWFGMGHFSQNYGWICVAPVIGGNVFNVVFGRVYDSNTVGRIGLPTGVSGTISELRRLVVKAAGEVGRHDCMCLVGEQCYGTAFKISALGCTVALGLSIWAGVRRRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE16</accession>
    <name>A0A1Y1UE16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_486364</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870391.1">
        <property type="nucleotide sequence ID" value="XM_022012916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE16"/>
    <dbReference type="FunCoup" id="A0A1Y1UE16">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE16"/>
    <dbReference type="GeneID" id="33554724"/>
    <dbReference type="InParanoid" id="A0A1Y1UE16"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="34"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="327"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="493" mass="54354" checksum="1C7F9BDBB335266C" modified="2017-08-30" version="1">MATTHVIGSSNPANHLSSGGSHSSSSSNIVGVHYKVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKSDAPQLRDEYRSYKILSGCVGIPQVYYFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSVKTCCMTARQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKGATTVHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFFYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIPELVDGYPQEFAIYLNYVRKLTFDETPDYDFLRELFLTAMKNNGDEDDQVYDWQLLNNGKGWETSSTAAASTTNEASRREGRTRPEKDYKDRMERMRSGPSGGPGASPLKQRKSAGQSGPLPNASNQAIVGVSAPSPLPTSRRQSAQGHPFASANPAHHDSARDGGREPYDPSNMAIPSQAGLQPIAPMTVNGQGGNTANSSQRMGEGDYQQQKGGNGFMRLISCGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE80</accession>
    <name>A0A1Y1UE80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_580813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870400.1">
        <property type="nucleotide sequence ID" value="XM_022013465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE80"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE80"/>
    <dbReference type="GeneID" id="33555273"/>
    <dbReference type="InParanoid" id="A0A1Y1UE80"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="329" mass="35777" checksum="52AB8ECED25B6E9E" modified="2017-08-30" version="1">MILKSGLIPPSPLSVFGAATDSLLSLPDDPCVAHTSRVTLIVAGSYVVAIAIREHVPILEKLLYPFKLLVVGMHELCHALAGVLTCAKIESIELDPNEGGSTRMRGGIPAITLPAGYLGSSLIGAALITVGFDTSASKVAAIVLLVLWAITLYWARRSWVAYATILMMAALIVITWLVAHSVALRFFILFIGVMSCLYAIWDIIDDTLARKVNSSDASEYAHLIGCCGSRFWGAFWLLQACVFFVAGILVGIVVFRDSWEQQRERADRFLGGKSTTASLVLTILRHSLNTAGTILVDQRANAMSVFCPYWTPHYRHPLLPPGGDRRDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEF5</accession>
    <name>A0A1Y1UEF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_642541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870470.1">
        <property type="nucleotide sequence ID" value="XM_022017491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEF5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEF5"/>
    <dbReference type="GeneID" id="33559300"/>
    <dbReference type="InParanoid" id="A0A1Y1UEF5"/>
    <dbReference type="OrthoDB" id="3356102at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013186273" evidence="2">
        <location>
            <begin position="18"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="427" mass="44167" checksum="E5CE16100A13AA1B" modified="2017-08-30" version="1">MLPILTLLSLIPSLVFAVPCVQFDTNWDLYAFGGNEDVKLGNSSSWSQPSVTPLSTSGRPPWTGQYTQCLQSQYNNAMYVLGADDSDLSKIYIYNFAEDSWSLQDTSAEPSNLGMSRSASVLDHDTNVIFTLTSGSGASLYQLDLSTIQATAGSSQAWSAVENPSFSTSGYTPVAAEASNHIHYFGVPDTAAGSADLFVVHYAYFQPTPQSYPTLNGGEAFPDSGGQAINVPNEANNAPDQMVFFPNDFSNSYVVTHWTNPGSYNSTSGVPFATDLINTTQILPAPSSQDQQASYAASPTDLVQIDTAGNIYYMTNAISSSYTVQSGASWTKMSYQLVGSGGSGGNTTSSSSSTSMTGGSSSTTGTSGSSETSAGASGSKTSGAASSGTSKSSSSTSGAAGVSASLGRWDLAGVVMTFAAVGGVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEI6</accession>
    <name>A0A1Y1UEI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDCD5-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_681955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870572.1">
        <property type="nucleotide sequence ID" value="XM_022019132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEI6"/>
    <dbReference type="FunCoup" id="A0A1Y1UEI6">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEI6"/>
    <dbReference type="GeneID" id="33560941"/>
    <dbReference type="InParanoid" id="A0A1Y1UEI6"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.140:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="161" mass="16734" checksum="3908A9381AE17BE7" modified="2017-08-30" version="1">MSNFQLPQGLRPAAPPSGAGPSGLSGGASGAGTAGGQGSSEQEQAAARERAQAQEEMKRTMIQAMLDSAARERLSRISLTRPQLAAQVEELLVRMGTSGQIRGQVSDDALKNLLEQVSNPPQAKTGAAPTVSTTGARTKSLGAGITIQRKRDDSDSDEYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEL7</accession>
    <name>A0A1Y1UEL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chondroitin AC/alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_609193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870083.1">
        <property type="nucleotide sequence ID" value="XM_022014146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEL7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEL7"/>
    <dbReference type="GeneID" id="33555954"/>
    <dbReference type="InParanoid" id="A0A1Y1UEL7"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="576"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="838" mass="91344" checksum="2E46A237EC45F245" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEU7</accession>
    <name>A0A1Y1UEU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_626446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870660.1">
        <property type="nucleotide sequence ID" value="XM_022015897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEU7"/>
    <dbReference type="GeneID" id="33557706"/>
    <dbReference type="InParanoid" id="A0A1Y1UEU7"/>
    <dbReference type="OrthoDB" id="2564476at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="80" mass="9285" checksum="B4D1F9F3DC59A291" modified="2017-08-30" version="1">MPTKRIRESTTVESDTSLMQTPPPKKTVRKSAYSDDEEERFIKALIEIAKDHMWQKVKNDPLLMYRGANGIRSHIEALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFC2</accession>
    <name>A0A1Y1UFC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_480415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870305.1">
        <property type="nucleotide sequence ID" value="XM_022012900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFC2"/>
    <dbReference type="GeneID" id="33554708"/>
    <dbReference type="InParanoid" id="A0A1Y1UFC2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="152" mass="16474" checksum="7B15D772D598A564" modified="2017-08-30" version="1">MTLTTIDSPAPQVSSRTAEDHVRPAPSVSIRRTTAMEPSSGLVESYVATGIRLPSARMLALSSSTPTMSPTVIKFQINVGSALRPVNWTTRPSQVDVRPPCSRTPPNRQGSEERGTALRSFGWTPRAAFRIVAAPRELENVGTKIRLSVSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFC4</accession>
    <name>A0A1Y1UFC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase C/P1 nuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_626938</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870791.1">
        <property type="nucleotide sequence ID" value="XM_022015948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFC4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFC4"/>
    <dbReference type="GeneID" id="33557757"/>
    <dbReference type="InParanoid" id="A0A1Y1UFC4"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF29">
        <property type="entry name" value="S1_P1 NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666032" evidence="8">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="393" mass="44025" checksum="C1BBA40944BF4198" modified="2017-08-30" version="1">MKAFTVAFAAAYLLPGALAWGAAGHEIVATIAQIHLHPSTRQRLCEILPERSKCHLATVAAWADTVRRYYPETAPMHYINPMSDHPSDHCEYGEHGWLNEDVNVLTGIMNETARIMAGQGDIPLRFLVHFMGDMHQPLHLTGRDKGGNGAMFLFEGHQRNLHSVWDSGLITKKIREISNYTSPLPSRQIEDALPGAIFDPYVRWIVWEGIRQWWRDELPEWLTCPADGDPFPHSSISDIPASTPDYLKNRISRTAFSALNAVLPAWITIPFQLKYPVQMHETHGFADQLLSTHPAILNGSVVSTLSPDPQLIKPVIPACPFSWSKPIHQLNCDIVWPKNYVPGRHIELDTKDYLGRIDSEKTLEKLLAMGGIRLASILNTILGDETAALNLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFT0</accession>
    <name>A0A1Y1UFT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870941.1">
        <property type="nucleotide sequence ID" value="XM_022018319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFT0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFT0"/>
    <dbReference type="GeneID" id="33560128"/>
    <dbReference type="InParanoid" id="A0A1Y1UFT0"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="428" mass="46677" checksum="92871720BCE24667" modified="2017-08-30" version="1">MSCGKDLLLLVWVHGFKGNEVTFESFPDRIKHLLETTHPSLKIVSKVFPAYQTRGELNAATLAFVDWLTSLVVELENDHGAGGGAGKARIVLMGHSMGGLLIADAARDIVANTRPGAPLWPQIIGVMAFDTPYLGLHPHTFKHGLSTAAGYYEQAKNIASAAGMLSPLAIGLGVGKWGKREDSTETGPTRAQTSAGTSKTTSTDTSIPQSASSTEPTKSSNWTIPRIPTPSTKALYGLGAVALGAAAAGTAYYRREDFLTGWKWGYEHMTFVKNLWDGEAMTKRLDDLYNLDTEHGVRFWNFYTYLPASQPKHLTSRTFIILPSTSHPLYPRFRPASNSLASDEVSAHMGMFNAKTNDGFYDLGLEVMRGMGERVEEAGVGTKTHTACWGVSEELEEALTKEYPSEKDALGNGWRVEDQDGKVVWVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGD7</accession>
    <name>A0A1Y1UGD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871169.1">
        <property type="nucleotide sequence ID" value="XM_022018194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGD7"/>
    <dbReference type="GeneID" id="33560003"/>
    <dbReference type="InParanoid" id="A0A1Y1UGD7"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="58710" checksum="22A409D9FEC464B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGP1</accession>
    <name>A0A1Y1UGP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_681110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871230.1">
        <property type="nucleotide sequence ID" value="XM_022019109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGP1"/>
    <dbReference type="FunCoup" id="A0A1Y1UGP1">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGP1"/>
    <dbReference type="GeneID" id="33560918"/>
    <dbReference type="InParanoid" id="A0A1Y1UGP1"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="594"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="668"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="758"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112784" checksum="68887C78BFF1B92B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGR7</accession>
    <name>A0A1Y1UGR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_625353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871266.1">
        <property type="nucleotide sequence ID" value="XM_022015786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGR7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGR7"/>
    <dbReference type="GeneID" id="33557595"/>
    <dbReference type="InParanoid" id="A0A1Y1UGR7"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="74" mass="8219" checksum="312840336D88357A" modified="2017-08-30" version="1">MSMLARTALRAPRQLVVRQQVRGLHFENELGKTIPTNTDNKVWTAMKIAMFAATGFGLPFYAVHHHLKKAAAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGX9</accession>
    <name>A0A1Y1UGX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_468822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870856.1">
        <property type="nucleotide sequence ID" value="XM_022012872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGX9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGX9"/>
    <dbReference type="GeneID" id="33554680"/>
    <dbReference type="InParanoid" id="A0A1Y1UGX9"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="51931" checksum="5A9C3FB636F36F5D" modified="2017-08-30" version="1">MTFSDAKRDDATAEDRSRHLSASSRQSASPTPPPSPPPWRSALGRAFFLLNSSFAHVSGENIANGANGDRYLALLKKSFRAYSDIPVGSDVLVEHAFPHGCSTKEIEWEVDIVPARGLLEGDQDIQYDLTGGRGDESPPIKAGNTRQVCWNCLAPGHSHTSCPQPRNHLLVRIMRDKFLAEKESMPTFAIPYMNSYSVTDEDKIRRLDLVDRFDPGRVSNTLADALFWIDPTLLRLPDETPGDKRDLEDGEVSDDFPERDQVLEIRGMRRRRAWPWINEMVRWGYPPGWIASKDPMIEVKRRIQQLPISTGDESEDDESDMLQVYGGIGSPLHLGDEAARSSASSSSPRSMSASSSSSSSSTSKPLLSPTQSVSSNMMLSPIVDPEPLPLLLPPQSCDQSAPPQPEDAIPPPPDQSATPPPPPPPNLPPPLPLPVSAPSAPRAQRWAKYDTDMFDSDRLKAFTTARPLPLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH30</accession>
    <name>A0A1Y1UH30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_642553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870496.1">
        <property type="nucleotide sequence ID" value="XM_022017493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH30"/>
    <dbReference type="FunCoup" id="A0A1Y1UH30">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH30"/>
    <dbReference type="GeneID" id="33559302"/>
    <dbReference type="InParanoid" id="A0A1Y1UH30"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="884"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="864"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1128" mass="126983" checksum="46DAE4B7475DEBFD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHB5</accession>
    <name>A0A1Y1UHB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_627688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870986.1">
        <property type="nucleotide sequence ID" value="XM_022016029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHB5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHB5"/>
    <dbReference type="GeneID" id="33557838"/>
    <dbReference type="InParanoid" id="A0A1Y1UHB5"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="477" mass="51359" checksum="EAA59295736150F5" modified="2017-08-30" version="1">MAFLGRPSGGDSPFAIGDRALRDHSSPQPPAQRNPTPRKNPGQRASVDGHPAGAGPGGAGSGGGGGGGGGGAAFMATPSPYGSVSDEARRRYEERYAKKKAEEAAKAEAEAREAEEKERQAQAAAQRPQGGQQGYGGPPQGFNGPPQQFFDPPPRQSSGYGQLPPPQQQQQQQSYHNGQRPPSLQPNPGPYSPNLQQPPQRWSNPNLPGGGGLSPQPQQAGFGGSQGHGSRPSSNQGHGYGGSQQGHGGPGYGGSHQGGHNPPPAGRMQWSANAVPPPSQQWNPQPKSPPPPPPPIAEPPRAEDAVLRTLFSQFDSSRSGSLNSYDLERLLAKDETMEAREDCVKMLMNIFDTDRSGSINFQEFEGLYRYIQDWHGIFLRFDRDGSGLIDRKELHQALLGFGFSLPLDMVRKLEKRFAPPPKPGHPPRKGISFDRFLMACVTVKHYTEAFRRTDVSGSGRITLDYNQYMDIILESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHU1</accession>
    <name>A0A1Y1UHU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_651141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870724.1">
        <property type="nucleotide sequence ID" value="XM_022018278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHU1"/>
    <dbReference type="FunCoup" id="A0A1Y1UHU1">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHU1"/>
    <dbReference type="GeneID" id="33560087"/>
    <dbReference type="InParanoid" id="A0A1Y1UHU1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="212" mass="23556" checksum="CBCE23AF05441A1D" modified="2017-08-30" version="1">MSKAQFLREYKLVVVGGGGVGKSALTIQFIQSHFVDEYDPTIEDSYRKQCIIDEEVALLDVLDTAGQEEYGAMREQYMRTGEGFLLVYSITSRSSFEEVSTFHQQILRVKDKDFFPVVVVANKCDLEFERQGRDLAKRFNAQCIETSAKQRVNVDEAFIAVVRAIRRYQRESGPPQPVAAPGKSVPGGVGGRTNEKADENVDKGCCGGCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI24</accession>
    <name>A0A1Y1UI24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_579078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871659.1">
        <property type="nucleotide sequence ID" value="XM_022013355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI24"/>
    <dbReference type="GeneID" id="33555163"/>
    <dbReference type="InParanoid" id="A0A1Y1UI24"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="782" mass="85579" checksum="9C2858E275CD6A88" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UID4</accession>
    <name>A0A1Y1UID4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GrpB protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_473246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870924.1">
        <property type="nucleotide sequence ID" value="XM_022012885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UID4"/>
    <dbReference type="GeneID" id="33554693"/>
    <dbReference type="InParanoid" id="A0A1Y1UID4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="231" mass="25633" checksum="E9B03D9448A760F1" modified="2017-08-30" version="1">MLQINVVPYNPEWPAHFEFIRAQLDDALADFLPKEKYEIIHVGSTSIPGLAAKPIIDLDIVVDAEDIMEATMALTANGYTYAYEANGIDRMVFRYDKHALDSGASKPTEDGTPRRAVYLNKRTGAALLNHLIVQRTLMNDPELRKEYGDVKLELVGEHSSIGAYGGKKNPVLSKILEKGATPEELRYIRSKPKRRIDEKLQAARKARIEADEKRVLADGKAEAGQADATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIV1</accession>
    <name>A0A1Y1UIV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_448824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871454.1">
        <property type="nucleotide sequence ID" value="XM_022012811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIV1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIV1"/>
    <dbReference type="GeneID" id="33554619"/>
    <dbReference type="InParanoid" id="A0A1Y1UIV1"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42414" checksum="5A807CC74571C853" modified="2017-08-30" version="1">MRLDEEHEHEILSRRHEEARTELAEGHGALNWVLVQRSDPEGQIYAGCDTYRIEALIKRKSKESIEDTFCYGITSVYTPVQHRKGYGRHLLRVLHYILARPRLPAFPLEWGDPPALAPKQRELVPWASFSFVCSDIGSEYYSKCTIGDSSEGFAVNPLEQNELHWKILPPEDEEGSFCRHGPGDDHREDDWLVLYDKDLPRIKSILREGQKRNLENRDTVDHSVFALDPEAGGVCDFVAQGGETGVREPWPILDKVEPRGVQRGDTVVMFARYDYQVPKDTLIISFVQKLTSDDLPSLLRVLDRLGTEVGLRNGWIWGLDPTSELVRSWEALPGRNTKVGLRQGNDAHLYGIARYEDQGGILVDQQMWIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ59</accession>
    <name>A0A1Y1UJ59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_421166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872068.1">
        <property type="nucleotide sequence ID" value="XM_022012729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ59"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ59"/>
    <dbReference type="GeneID" id="33554537"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ59"/>
    <dbReference type="OrthoDB" id="2564987at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965596" description="RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27202" checksum="E29DADC848D91CD7" modified="2017-08-30" version="1">MPARLSITLPLLVLSRGTLAVLFEKQGTSATVYYDLTNSFCTSEDSITGGGQWALGPNNQPTKCAPNAGYRSPAQIGSNSIVAFNQDLVWANRAKWCGKQVQIFDASGKEIHGPDGPFYIWDSCENCAKDDHIDLSAEAWSALGGECTVNNPSGISYKVLDTNIKQWRPDSPAGDNPDPVSSVGLSSASIQIVASAPVSSSAVQAAVGSSCTYGRYQCVGATLQQCNNVGQPARLDWQTIVPACANYCDVTRTPVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJH6</accession>
    <name>A0A1Y1UJH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)</fullName>
            <ecNumber evidence="3">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_619961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872125.1">
        <property type="nucleotide sequence ID" value="XM_022015234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJH6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJH6"/>
    <dbReference type="GeneID" id="33557042"/>
    <dbReference type="InParanoid" id="A0A1Y1UJH6"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="209"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="525" mass="57032" checksum="E98A02C1D44AFF54" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJR3</accession>
    <name>A0A1Y1UJR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_579666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871403.1">
        <property type="nucleotide sequence ID" value="XM_022013398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJR3"/>
    <dbReference type="FunCoup" id="A0A1Y1UJR3">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJR3"/>
    <dbReference type="GeneID" id="33555206"/>
    <dbReference type="InParanoid" id="A0A1Y1UJR3"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="453"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="679" mass="75121" checksum="023B55EAC880E2A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK28</accession>
    <name>A0A1Y1UK28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872330.1">
        <property type="nucleotide sequence ID" value="XM_022015318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK28"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK28"/>
    <dbReference type="GeneID" id="33557126"/>
    <dbReference type="InParanoid" id="A0A1Y1UK28"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="195" mass="21169" checksum="F5D6E4BD6659A1F4" modified="2017-08-30" version="1">MSSQPTYTYTVSSAAYALPLLHAARYLSHTVIGILLGKIDRGSKRVSVEDALPLIHHYTSLSPMMEVALELGAAAASERGMEVVGLYVVPKDDKNSGLGRVGERILGEMKGKFDASFAWLVDNEKLGEGSVPYTIYTISQSSTSPQALPSKSSSSFPSPFTLDSTPNLPARTLQAIRDEKIHRNLVDFDDHLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKB4</accession>
    <name>A0A1Y1UKB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mu homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_620806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872344.1">
        <property type="nucleotide sequence ID" value="XM_022015324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKB4"/>
    <dbReference type="FunCoup" id="A0A1Y1UKB4">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKB4"/>
    <dbReference type="GeneID" id="33557132"/>
    <dbReference type="InParanoid" id="A0A1Y1UKB4"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="436" mass="49827" checksum="D30691688A285E52" modified="2017-08-30" version="1">MASLVAILDVKGKSLIQRSYKDDVPPSCIERFLPLVLDMEEENVQVTPCFSDDGINYMHIRHNNLYLLALSKRNSNAAEIIFFLHRLCSVLTEYFKELEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLELQARPPMAVTNAVSWRSEGIRYRKNEVFLDVVESVNLLVNASGNVIRSEILGAVKMKCYLSGMPELRLGLNDKVMFESTGRAARGKSIEMEDVKFHQCVRLARFENDRTISFIPPDGEFELMSYRLSTPVKPLVWVEASVESHRGSRVEYMVKVRGQFKRRSTANNVEIYVPVPDDADSPKFRAAAGSVVYAPEKSAFVWKIKQLGGGRDYLMRAHFGLPSVRNEELDKRAPISVKFEIPYFTVSGIQVRYLKIVEKSGYQALPWVRYITQNGDDYVLRTISDAKSSSIIAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKL6</accession>
    <name>A0A1Y1UKL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_621518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872515.1">
        <property type="nucleotide sequence ID" value="XM_022015388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKL6"/>
    <dbReference type="FunCoup" id="A0A1Y1UKL6">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKL6"/>
    <dbReference type="GeneID" id="33557197"/>
    <dbReference type="InParanoid" id="A0A1Y1UKL6"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="835"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1209" mass="132044" checksum="178C2AF0C135F22B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKV0</accession>
    <name>A0A1Y1UKV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_577767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872089.1">
        <property type="nucleotide sequence ID" value="XM_022013278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKV0"/>
    <dbReference type="GeneID" id="33555086"/>
    <dbReference type="InParanoid" id="A0A1Y1UKV0"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="899" mass="101310" checksum="50027B8CDE6A8C56" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULB6</accession>
    <name>A0A1Y1ULB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_576636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872694.1">
        <property type="nucleotide sequence ID" value="XM_022013201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULB6"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULB6"/>
    <dbReference type="GeneID" id="33555009"/>
    <dbReference type="InParanoid" id="A0A1Y1ULB6"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="188" mass="20157" checksum="9F39B257D5EA575B" modified="2017-08-30" version="1" fragment="single">VEYYFSMQNLAMDFFLRQQMDSEGWIDIPVIASFNRVKNLTTDVGLVKEVMQLSTLLEVREDKVRLAYGESKRWVLPEAKPSVFPADPPSDPMVLSPHSDAATAELVNSISGLGIDAMPGSGTMNGAAVGSVPKMASGEVEHALMKNASTSSATSVLNGEEGGIKTDTETPGTSMSGDRVEELADEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULL0</accession>
    <name>A0A1Y1ULL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_294851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872732.1">
        <property type="nucleotide sequence ID" value="XM_022012405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULL0"/>
    <dbReference type="GeneID" id="33554213"/>
    <dbReference type="InParanoid" id="A0A1Y1ULL0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="212" mass="23217" checksum="0E993D960B5B2832" modified="2017-08-30" version="1">MMIMKWAIVVCPAFKVAEESIIHSIPYRSAPDSFSSSSITFVSRIVILICGPKADRHSAFIIDSSSSVVEGTHTFLKAKGSGTKCIDSEDPLIASSSLDIKTDFHPWIHVSTLEVGVEHKRNSAQPHRVSVLHTFQWEIGHPHLWSSNSVLTASLVSLTYLVLPLYSSKPINQSAPSENRPLILTSSSHTSFKGPDSRSPTLVPRGSLLFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULQ2</accession>
    <name>A0A1Y1ULQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_357063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872356.1">
        <property type="nucleotide sequence ID" value="XM_022012572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULQ2"/>
    <dbReference type="FunCoup" id="A0A1Y1ULQ2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="33554380"/>
    <dbReference type="InParanoid" id="A0A1Y1ULQ2"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="675"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="723"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="825"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="905" mass="96407" checksum="C8276981A9CA178A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULQ5</accession>
    <name>A0A1Y1ULQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_357896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872366.1">
        <property type="nucleotide sequence ID" value="XM_022012573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULQ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULQ5"/>
    <dbReference type="GeneID" id="33554381"/>
    <dbReference type="InParanoid" id="A0A1Y1ULQ5"/>
    <dbReference type="OrthoDB" id="2576541at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19184" checksum="5183FDF421E76080" modified="2017-08-30" version="1">MTTISTDEAGSTKIITQVVTSIPSSTPSTDSDAASNTYTSSNNEDSSSLSTPAIIGISVGAGVLVLSLIACAVWRMKRRHGDEDEAIRWPELNRHGDADTHHALPARVTGQHGIETNPLVSLSFKSSRAGRLIPFTATLLVQFFVHLRSILHRSPSLCPAHGSQRLWLRCRIVFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULR9</accession>
    <name>A0A1Y1ULR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor Vps9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872348.1">
        <property type="nucleotide sequence ID" value="XM_022018048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULR9"/>
    <dbReference type="FunCoup" id="A0A1Y1ULR9">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULR9"/>
    <dbReference type="GeneID" id="33559857"/>
    <dbReference type="InParanoid" id="A0A1Y1ULR9"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="284"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="69812" checksum="CC1F4108C81F8E82" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULT3</accession>
    <name>A0A1Y1ULT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872386.1">
        <property type="nucleotide sequence ID" value="XM_022015343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULT3"/>
    <dbReference type="GeneID" id="33557152"/>
    <dbReference type="InParanoid" id="A0A1Y1ULT3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="292" mass="31507" checksum="E47B51840F04EBA9" modified="2017-08-30" version="1">MSSITKAADSVDQKALTTRNFIISAQIQIDQRAQDEISSISSSSNSVHQYAQKTLNCMSAAQIRVNQQAQDAISKAADSVDQQAQEATSSISNSADSVDQHAWTTCNFISSAEIRVDQYAQDAISTISSASDRVEPPRPAVKTRPAEARPAATPVATRPAATAATRPAATPAVDRPAKKRRTVPKTGPRKPTGPPKPKCPLMSPSTSPVPVQPAPAPAPAPAPAPAMSAKDKIKAGDRSFANFTAAMEDDLSFEWWQTQYSMPGNDWDLRRWIMGGWEKAEELRNHRRLYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULY0</accession>
    <name>A0A1Y1ULY0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GC-rich sequence DNA-binding factor-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_679519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872872.1">
        <property type="nucleotide sequence ID" value="XM_022019043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULY0"/>
    <dbReference type="FunCoup" id="A0A1Y1ULY0">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULY0"/>
    <dbReference type="GeneID" id="33560852"/>
    <dbReference type="InParanoid" id="A0A1Y1ULY0"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="306"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="993" mass="110334" checksum="C59C7BA4E21EFF89" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMA3</accession>
    <name>A0A1Y1UMA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_649642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872187.1">
        <property type="nucleotide sequence ID" value="XM_022018027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMA3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMA3"/>
    <dbReference type="GeneID" id="33559836"/>
    <dbReference type="InParanoid" id="A0A1Y1UMA3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1100" mass="117571" checksum="CF55F330D88C65BB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UME9</accession>
    <name>A0A1Y1UME9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_621780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872568.1">
        <property type="nucleotide sequence ID" value="XM_022015405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UME9"/>
    <dbReference type="FunCoup" id="A0A1Y1UME9">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UME9"/>
    <dbReference type="GeneID" id="33557214"/>
    <dbReference type="InParanoid" id="A0A1Y1UME9"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="323" mass="35291" checksum="1E0F9665DF6BCC70" modified="2017-08-30" version="1">MSSAANHLLYILTDSNLPTGGFIASSGLESYVTHGFLKSTEGDARGSKGAATTGTTAKASKSDSIGEWITRFGTAEMDNYASTTVPYLNDAWTASTSYLAIDHPSDSDLPTVIDRLETLDNYHEASLLSHVARRASKAQGVAILMLYVRSFAGQQNQTQRVGPDEGTNARLADELVAKYKHRIRAGKAPGHLSICFAILCAALDLTREQCLHLHLYLHARSVLSSAVRLNQVGPYESTSLLATRFKDLVEVAMRSHGGAGTGLFRDQEDTSTIEGQTMPRKKVQQEFWAWAYDAETFGPATTWPLGEILLARHDLQHTRLFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMI0</accession>
    <name>A0A1Y1UMI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIP18 family-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_576689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873126.1">
        <property type="nucleotide sequence ID" value="XM_022013205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMI0"/>
    <dbReference type="FunCoup" id="A0A1Y1UMI0">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMI0"/>
    <dbReference type="GeneID" id="33555013"/>
    <dbReference type="InParanoid" id="A0A1Y1UMI0"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000014">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.16, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="4">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="203" mass="22682" checksum="B1D7A30764A01003" modified="2017-08-30" version="1">MSSSRPLDNVNPTIFAPTSASSSSRRPKNARALLWNDALDNYELDSSEEEREEIDSQEIFDLLRSITDPEHPVSLEQLRVVNPEDIHVAGNRVLVWLTPTIPHCSMSTLIGLSLRVRLLRALPPRFRVDIRIKPGTHQSEHAVNKQLNDKERVQAALENQHLLQVVEGCLATASQRGMPSLEVKAEEEQGSKPAARGTMPWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMP7</accession>
    <name>A0A1Y1UMP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_325543</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873191.1">
        <property type="nucleotide sequence ID" value="XM_022012488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMP7"/>
    <dbReference type="FunCoup" id="A0A1Y1UMP7">
        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMP7"/>
    <dbReference type="GeneID" id="33554296"/>
    <dbReference type="InParanoid" id="A0A1Y1UMP7"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="411"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="549"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="979"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1077"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="980"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="998"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1112"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1171"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1193"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1203" mass="131653" checksum="939A01CF6379C2B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMX1</accession>
    <name>A0A1Y1UMX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_294568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872720.1">
        <property type="nucleotide sequence ID" value="XM_022012403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMX1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMX1"/>
    <dbReference type="GeneID" id="33554211"/>
    <dbReference type="InParanoid" id="A0A1Y1UMX1"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="141"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="310" mass="33358" checksum="6CA615EB094D4EC8" modified="2017-08-30" version="1">MSGDSTTASSTRVAQSSPSAALKIKFSVKGKGLPSSVDLGGSGTKRPSRAAARKSSKRTKMVAMDVDLGSDEDELDVMEEGDDPTDELDSGQNSAQRSTSPSKMTARQRARGNKDLQETLLELPHGNEGSSKKQLILTEAERIQRREEVARRRKRQTEQKLQDEQDQTINRLLRAQTGRSRAKLDVPSPGEEGGTGGGGSGVGGSRYPSPSRRTTTAAPLENMIRWISSIQDDNVVLRVAAPAGKEDWIAVSDATLAEDSTDTKPVLRRDARGTCGVDGCDAERKYRSVKKFETGGCSMEHLRAVEAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNH4</accession>
    <name>A0A1Y1UNH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_608070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872597.1">
        <property type="nucleotide sequence ID" value="XM_022014100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNH4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNH4"/>
    <dbReference type="GeneID" id="33555908"/>
    <dbReference type="InParanoid" id="A0A1Y1UNH4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="562" mass="61519" checksum="18D7582D31555C60" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNX7</accession>
    <name>A0A1Y1UNX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_614666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873487.1">
        <property type="nucleotide sequence ID" value="XM_022014626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNX7"/>
    <dbReference type="FunCoup" id="A0A1Y1UNX7">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNX7"/>
    <dbReference type="GeneID" id="33556434"/>
    <dbReference type="InParanoid" id="A0A1Y1UNX7"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="159" mass="17843" checksum="4B5D0E2F4B19BBBB" modified="2017-08-30" version="1">MAGVNEERPLQLDNAGTLNQSVSTSLEVDKIGILPGHESDYSACTFVLNHEDHTLGNALRWMIMKDADVEFCGYSAPHPSEPKIHLRIQMYDNMSAVDCLRKALSNLRDLLSTVDQKYKKSLRNDKYIKEDDVDVRAVVEETLRERGRLASSGDAMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP48</accession>
    <name>A0A1Y1UP48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_607033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873605.1">
        <property type="nucleotide sequence ID" value="XM_022014045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP48"/>
    <dbReference type="GeneID" id="33555853"/>
    <dbReference type="InParanoid" id="A0A1Y1UP48"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="205"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="629" mass="70672" checksum="0E4DF04F5C73FD94" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPR7</accession>
    <name>A0A1Y1UPR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_615684</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873747.1">
        <property type="nucleotide sequence ID" value="XM_022014749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPR7"/>
    <dbReference type="FunCoup" id="A0A1Y1UPR7">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPR7"/>
    <dbReference type="GeneID" id="33556557"/>
    <dbReference type="InParanoid" id="A0A1Y1UPR7"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="147" mass="16425" checksum="6C390A92F3E06A4D" modified="2017-08-30" version="1">MLPSLARVVLRSRAPVVSARHVGPVATRLMTVRFASGSGSHPHETESFEQFNARYAGFFESCNDLFELQRGLNNCFAYDLVPTVEVIQAALKCARKVNDYATAVRILEGLSVKVENKGQYQQYLDELKPLLEELGINSKEDLYGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPX9</accession>
    <name>A0A1Y1UPX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_648265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873412.1">
        <property type="nucleotide sequence ID" value="XM_022017811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPX9"/>
    <dbReference type="FunCoup" id="A0A1Y1UPX9">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPX9"/>
    <dbReference type="GeneID" id="33559620"/>
    <dbReference type="InParanoid" id="A0A1Y1UPX9"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000908">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="652" mass="70719" checksum="8B3BD394BE69F240" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ39</accession>
    <name>A0A1Y1UQ39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_616674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873963.1">
        <property type="nucleotide sequence ID" value="XM_022014847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ39"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ39">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="33556655"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ39"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="515" mass="56243" checksum="55D7508A5D71F8C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQB0</accession>
    <name>A0A1Y1UQB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_616882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873998.1">
        <property type="nucleotide sequence ID" value="XM_022014863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQB0"/>
    <dbReference type="FunCoup" id="A0A1Y1UQB0">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQB0"/>
    <dbReference type="GeneID" id="33556671"/>
    <dbReference type="InParanoid" id="A0A1Y1UQB0"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="271"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="476" mass="54585" checksum="26E599ED51031669" modified="2017-08-30" version="1">MSDDEFMMEDAADEEYDFDYDDDDDDEGMDEQGGDVENQYYKAKSLKEDDAEGALKAFRTIVDEEADKGEWGFKSLKQMTKMNYLHMKRPSEALKTYRELLSYTKSNVTRNYAEKSINNILDYVGGEGKHGALAPEVPLDTLESFYSATKEACDEARNERLSTKSNLKLAKLWLDRKEYDRLQPILRSLHASCGPSSSSSGSEDQTKGSLLLELYAIEIQMYSDLKETRKLKEIYNASMQVKNAIPHPRIMGVIRECGGKMWMMERAWDNASTDLFESFRQYDESGSPQRIQVLKYLVLTYMLMGSEINPFDSQETKPYKNDPQIVAMTGLVSAYQMRDVQEAERILKANRATITGDPFIQFFINDLLRSLRTQYIIDIIKPYTRLELDYLAKTLNIARNEVEALVISLILDRKIKGKIDQVNGLLVLERFHAVQNRKYKALEDVTREISNLGQRIINEKVAGWEGGQGTWSRAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URD8</accession>
    <name>A0A1Y1URD8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_611512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874289.1">
        <property type="nucleotide sequence ID" value="XM_022014274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URD8"/>
    <dbReference type="FunCoup" id="A0A1Y1URD8">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URD8"/>
    <dbReference type="GeneID" id="33556082"/>
    <dbReference type="InParanoid" id="A0A1Y1URD8"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="249" mass="26232" checksum="989CB04ED6930E1C" modified="2017-08-30" version="1">MDAKLQKLKVAELKELLSKHNLPQTGKKDELVKRLVENNISTEEGDEELLDPDDVETDQATAPTSSAVPAASTLTSAGEMPEKSTDPTNGSSVELTPEQQAMKARAERFGMPYNPNASSRSGQKSGSGSEKATAQQPHTPASSSTSQAQKAGPIDKAPLGVSEETLAKRAAKFGLPEKTSAAATAPAAESRTKAASTPAPPKAEAEMTPELKEKIAIEEEKKRKRAEKFGTAQPTNGTAAEPDAKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URE3</accession>
    <name>A0A1Y1URE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_611586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874312.1">
        <property type="nucleotide sequence ID" value="XM_022014283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URE3"/>
    <dbReference type="STRING" id="4999.A0A1Y1URE3"/>
    <dbReference type="GeneID" id="33556091"/>
    <dbReference type="InParanoid" id="A0A1Y1URE3"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011835342" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="184"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="43471" checksum="71379BF9FA7B292A" modified="2017-08-30" version="1">MLVPAAAAALALPFTLAAPAARSLVFQHDSNIPIAKPDIISQSSYDWSMDLNELRLVQFAEDELAVWITEHDKIRARADGKNFMDITDTPSLGFSSFLSGALVKNEYPAPGNHSKAIKEINKNLDVSSMRSFLKEFTGFRTRYYRSDTGKQSQQFLMSTLQKLSSHHKGVEISEFAHTWTQSSIIARFNPSSEDLKSAPVVILGAHQDSTNAWPFLPAPGADDDGSGTTSMLEAFRALATANFTPSRPVEFHFYSAEEGGLLGSQAVAKDYEDRGVKVRGMMHMDMTAWVKKGTEEVAAIMEDNTDPALTDFVEALIVEYLSIPAARTKCGYACSDHASFTKAGYQAACASESTFDNINHNIHSTQDTIDHPEFSFSHMKEFSKLAVAFAVELGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URJ8</accession>
    <name>A0A1Y1URJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_611734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874349.1">
        <property type="nucleotide sequence ID" value="XM_022014301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URJ8"/>
    <dbReference type="FunCoup" id="A0A1Y1URJ8">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URJ8"/>
    <dbReference type="GeneID" id="33556109"/>
    <dbReference type="InParanoid" id="A0A1Y1URJ8"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="223" mass="22440" checksum="25ECB715D640C76F" modified="2017-08-30" version="1">MSGRGFSRGGGSGFGGRGGGRGGFGGGRGGGRGGFQQRDFGPPDVVQEIGSFMHPVESEMLCSLTAPTKIPYFNAPIYLSNKTQIGKVDEILGPINEVFFTVKMDQGMMANSFKKDDKVYIGGDKLLPIERFLPKPKIAGAKVEKRGGARGGGRGGPRGRGGPPGRGGGRGAPRGRGGFGGDRGGGRGGARSFSSGGRGAPRGRGGFGGGGGGGFGGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URM5</accession>
    <name>A0A1Y1URM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874390.1">
        <property type="nucleotide sequence ID" value="XM_022017689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URM5"/>
    <dbReference type="GeneID" id="33559498"/>
    <dbReference type="InParanoid" id="A0A1Y1URM5"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="116487" checksum="A6838F1EEEB41BDB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URR7</accession>
    <name>A0A1Y1URR7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_615215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873630.1">
        <property type="nucleotide sequence ID" value="XM_022014694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URR7"/>
    <dbReference type="FunCoup" id="A0A1Y1URR7">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URR7"/>
    <dbReference type="GeneID" id="33556502"/>
    <dbReference type="InParanoid" id="A0A1Y1URR7"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="5"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="564" mass="61379" checksum="F1E5E4DC8A14166F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US68</accession>
    <name>A0A1Y1US68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_612151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874481.1">
        <property type="nucleotide sequence ID" value="XM_022014360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US68"/>
    <dbReference type="STRING" id="4999.A0A1Y1US68"/>
    <dbReference type="GeneID" id="33556168"/>
    <dbReference type="InParanoid" id="A0A1Y1US68"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="244" mass="26587" checksum="5208B376B327A935" modified="2017-08-30" version="1" fragment="single">MAEELQTAKDQLAYVNLSLDSDPTNDDLLKLKAELLELIDLTEAALGGSGGAGASGPKSGTDAGKGKGKAKDAPTNWQDLGPYKAGMDCMAKYKDGKFYPAKINAVTGSQDKPIYTITFKGYSSSTSVDLASLKPHDPSAPIPRPEKRRPDQLSEREKEKKKKKGEKWMETQQAKADDMKEKKTAWDKFGKKAQKKGIHISGLEGKSVFRTPDNPFGRVGVTGSGKGVTEYERMGKHKFDTKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USB3</accession>
    <name>A0A1Y1USB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_28040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874597.1">
        <property type="nucleotide sequence ID" value="XM_022012366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USB3"/>
    <dbReference type="FunCoup" id="A0A1Y1USB3">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USB3"/>
    <dbReference type="GeneID" id="33554174"/>
    <dbReference type="InParanoid" id="A0A1Y1USB3"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="151"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="235"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="29376" checksum="95E070D89195E133" modified="2017-08-30" version="1">MSVVVIGSMSRLDEYQSLLTSHKNVRGEMVDRVLDGATTLPPAPLDLHLVIPQPIPSTLLSMIPPSTTVHVHLGPSDDPAAIITAMSTFHPLPSTPSVLSFTAPSPHVVPLRTLKRNPTDRAKKSALWALDSPLLPDGGRSLLTPEDKQRPECTIPDTSGKPVKRRRACKDCTCGLKELEEEEDARSAAAVREAQKSFFLEGDDDIPENVKKATEGMEGVWPVDKRAEAKKTSSCNSCYLGDAFRCSSCPYLGLPPFQPGEKVQISLGDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USP1</accession>
    <name>A0A1Y1USP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_34359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874708.1">
        <property type="nucleotide sequence ID" value="XM_022012527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USP1"/>
    <dbReference type="GeneID" id="33554335"/>
    <dbReference type="InParanoid" id="A0A1Y1USP1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="235" mass="25778" checksum="F9834018ED92C842" modified="2017-08-30" version="1">MAPVSPSLVRPLMIGVQALAEAVVDLSSIEASVPSKGAMCYTSCRLPPTAKGGRRYPERRPLDDLRNYKGFHLTRGMANPQGLAAIAMMIKHAPVSLIRCSTSETMTTWGSHPPRPRFLPKSGLGRNPLAALVSRRKSSISSRAAPIPAPLSIVDCFQWTRLCLSSFLDRQGGLDIVIRKEVYSTRIIAFVDQASPYGCTIVLSPPVHVYRLSENISRENLAKSRSAYFTLRLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT59</accession>
    <name>A0A1Y1UT59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874888.1">
        <property type="nucleotide sequence ID" value="XM_022017779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT59"/>
    <dbReference type="GeneID" id="33559588"/>
    <dbReference type="InParanoid" id="A0A1Y1UT59"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="249" mass="28386" checksum="AEE886C8F1CF5069" modified="2017-08-30" version="1">MSSTEELEGLIRRIIDSRLIRYNHATCWRPVESKSTIQEMWTADYKEPRASSAANLPSDSTTDNRRGTARFRSEPVPRSLSVFPWELNGPGCEYVTEGSLPVKEREEAKIQLTTFRDKSKARRHRLMKTLLGEQSKTYGPSFRLLDDVVLSLRTEDLDDPSDVNYATACASTDKWFSSYIASGAPSTSALEQYAVLLAWQEAFSHPRETTDKWDFETIQGLKDQYFRDTDKILSAWDLEESHQTGSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT86</accession>
    <name>A0A1Y1UT86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">BD324DRAFT_611922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT86"/>
    <dbReference type="FunCoup" id="A0A1Y1UT86">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT86"/>
    <dbReference type="InParanoid" id="A0A1Y1UT86"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="207"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="295" mass="32062" checksum="D20C682873950BB1" modified="2017-08-30" version="1">MSSGHPDCLNATEEDIQLLLSAQCHLGTKNCDKTMEPYVWKRRADGIHVLNIGKTWEKLVLAARILSTIDNPNDICVISARPYGHRAVLKYAGFTGAQPIAGRFTPGNFTNYITKSFKEPRVIVVTDPRVDHQAIREAAYVNIPVIAFCDTDASLKFVDVAIPTNNKSRHAIGLMWYLLCREVLRLRGTVPRGPTGPSGWDVLPDLFFYRDPEEIEREAAEKAAANAQEGYEGADASAAVGAVQSEFAAGNAADAVFNAEPTAQNLDWSAEAQTGNAGDWAADPQEATQDATGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTK6</accession>
    <name>A0A1Y1UTK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_647452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874204.1">
        <property type="nucleotide sequence ID" value="XM_022017661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTK6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTK6"/>
    <dbReference type="GeneID" id="33559470"/>
    <dbReference type="InParanoid" id="A0A1Y1UTK6"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="156" mass="17009" checksum="D26C4A720D02E270" modified="2017-08-30" version="1">MPKGWFNIDDQTDDIIFGGEKSAFSSLGLTRYQRLGGFVICFIAGFGISILGAIMLFLGATGAFATLFAVGAIVSLIGTGFLIGFRTQLEKMFKPVRVVATILLFAAIAMTFVSAFVLPAILCIVFVIVQYLAFLWYSLSYVPYARTMVKNMVGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTV6</accession>
    <name>A0A1Y1UTV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_612323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874535.1">
        <property type="nucleotide sequence ID" value="XM_022014382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTV6"/>
    <dbReference type="FunCoup" id="A0A1Y1UTV6">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTV6"/>
    <dbReference type="GeneID" id="33556190"/>
    <dbReference type="InParanoid" id="A0A1Y1UTV6"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="268"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="384"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="667" mass="75854" checksum="9A66FB9599666B74" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUA3</accession>
    <name>A0A1Y1UUA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid metabolism-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_613355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874813.1">
        <property type="nucleotide sequence ID" value="XM_022014488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUA3"/>
    <dbReference type="FunCoup" id="A0A1Y1UUA3">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUA3"/>
    <dbReference type="GeneID" id="33556296"/>
    <dbReference type="InParanoid" id="A0A1Y1UUA3"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="141"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="352" mass="39490" checksum="2732D7F01799C99E" modified="2017-08-30" version="1">MASFADTVRFCFPTASSSANGTRYRGSEELSLQDRRRAPDAWIEEDDLGKDTAKFSLAGIFKSYAPDWMLVVLLWVVYAILNRSGGHKREFSLNDISIQHTFAEHERVPPNLLFFISAGIPLLVLVPVSAFVARTGWDMHNAVVGVFMSYTMTGTVTQLIKMSVGRPRPDLLARCLPREGSADHVFFGLSTVDICTTTNQLRLDDGFKSFPSGHSSLSFAGLGFLSCYLAGKMHLWDRRGHRTRGWFALSPLLGAVMVAISRTEDNRHHWQDVLVGSLLGLFIAWVSYRTYFPPLSHRQCHLPLAPRSPDTIGVVEGDEEMGRNGTRVRLLEEEEEQAQSRPSEEQVTWRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUC7</accession>
    <name>A0A1Y1UUC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_46413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874843.1">
        <property type="nucleotide sequence ID" value="XM_022012857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUC7"/>
    <dbReference type="FunCoup" id="A0A1Y1UUC7">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUC7"/>
    <dbReference type="GeneID" id="33554665"/>
    <dbReference type="InParanoid" id="A0A1Y1UUC7"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="159"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="431" mass="48437" checksum="EB419986944ACD48" modified="2017-08-30" version="1">MTVAKMFDRQTELPNRDQLETDLELKGLQDREVGQLSGGELQRFAIAIASVRNADIYMFDEPSSYLDIRQRLAAARVIRGLVTATNYVVVVEHDLATLDYLSDFICVLYGVPGIYGVVTMPYSVREGINIFLDGMIPTENLRFREESLTFKISENADELQAVHTQAYHYPAMTKTLGGFKLQVEPGDFADSEIIVLLGENGMGKTTLVQLLGGKLEPDDPKDKVEMRVSMKPQTSERSVWGGAHRSVSPKFPGTVRMLLIKRIKSMFMHPQFNSDVLKPMNLEGIMDQDVQTLSGGELQRVAICLVLGVPADVLLIDEPSAYLDSEQRIHASKVIKKFVMSSKRTAFIVEHDFIMATYLADRVIVFEGQPAVSSTARTPEGLLTGMNKFLRSLDITFRRDPTNYRPRINKMESLKDKEQKQSGSYFFVDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U657</accession>
    <name>A0A1Y1U657_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative heat shock protein HSP60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_639646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867847.1">
        <property type="nucleotide sequence ID" value="XM_022017258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U657"/>
    <dbReference type="FunCoup" id="A0A1Y1U657">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U657"/>
    <dbReference type="GeneID" id="33559067"/>
    <dbReference type="InParanoid" id="A0A1Y1U657"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="595" mass="63085" checksum="6B92AA142017D611" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6V3</accession>
    <name>A0A1Y1U6V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="8" type="ORF">BD324DRAFT_638490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6V3"/>
    <dbReference type="FunCoup" id="A0A1Y1U6V3">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6V3"/>
    <dbReference type="InParanoid" id="A0A1Y1U6V3"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="259" mass="29272" checksum="4D840FCFC369F38B" modified="2017-08-30" version="1">MAVGKNKRLSKGKKGIKKKVVDPFTRKEWYDIKAPGFFENRSAGKTLVNRTQGMKNSADSLRGRVLELSLADLNNDQEQSFRKIKLKVEEVSGKSCLTSFYGMDFTTDKVRSIVRKWQTLIEASVDVRTTDGYVLRLFSIGFTKRQANQVKKTTYAKSSQVREIRAKMVEIMRREAEGSDLKELVKKFVPESIGREIEKACKGIYPLHNVYIRKAKILKAPKLDMSKLLETHGEAMDANTGSKVVKGGDFVEPEVLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8W3</accession>
    <name>A0A1Y1U8W3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_637744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868224.1">
        <property type="nucleotide sequence ID" value="XM_022017041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8W3"/>
    <dbReference type="FunCoup" id="A0A1Y1U8W3">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8W3"/>
    <dbReference type="GeneID" id="33558850"/>
    <dbReference type="InParanoid" id="A0A1Y1U8W3"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="21040" checksum="A9CAE9BFA5C256C6" modified="2017-08-30" version="1">MDDDYYSLQSILADNHKLSCTFTLDVPGLGYLEGSTEPDIHQNSKVEIPFWLAQTLSLNEFTTFPLPPAYSNRVRAALNASAPSVKLSHLVGGGGCWYRWGRRIAEVLDDQPQADLLNMLLNAFLARLPPLQDLSAHIASADHSIPEGDAGSGESFREGMEGDERDLFSVGQDSARITKAWYDSNGRKAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U951</accession>
    <name>A0A1Y1U951_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868805.1">
        <property type="nucleotide sequence ID" value="XM_022018642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U951"/>
    <dbReference type="STRING" id="4999.A0A1Y1U951"/>
    <dbReference type="GeneID" id="33560451"/>
    <dbReference type="InParanoid" id="A0A1Y1U951"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="301" mass="30886" checksum="2F552FF5100AFF12" modified="2017-08-30" version="1">MPNVVNVTLDNVDPNIKYSGNWNGNAAGDRFYASYYDQTFQSSGADGDYFEFSWTGGDVFLYGGYGSDHGYYSLIMDGGDKIYANGYSDPGAARQLIGASSGYPYGQHTVRLTNENQYNPTEGRTLLDLDYIVVELDPEADDGGATTSSTATTTTSTAPVISALPSTTRQVIDGAMESQTALRITSNSVAPPPSTTTGITSSSSSPTASAPSHTSSISSAASSAPVGSRLPAVGGPHITVQPGSETVPIAVGSGTPSFSPVAIPTDHVLSGPARAASLSPSLSALMAIILVTWALGASPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U961</accession>
    <name>A0A1Y1U961_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_636372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868815.1">
        <property type="nucleotide sequence ID" value="XM_022016891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U961"/>
    <dbReference type="STRING" id="4999.A0A1Y1U961"/>
    <dbReference type="GeneID" id="33558700"/>
    <dbReference type="InParanoid" id="A0A1Y1U961"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000063">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="235"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="656"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="933" mass="103820" checksum="9205431175A6ECC3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U971</accession>
    <name>A0A1Y1U971_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_636404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868825.1">
        <property type="nucleotide sequence ID" value="XM_022016896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U971"/>
    <dbReference type="STRING" id="4999.A0A1Y1U971"/>
    <dbReference type="GeneID" id="33558705"/>
    <dbReference type="InParanoid" id="A0A1Y1U971"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="75"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="284" mass="30729" checksum="D4F3B57890EC8D1D" modified="2017-08-30" version="1">MPLFLPLVSPKAYAKIQYASSLSSLSHTNNVSLASLQLTIPLLEDESAALQGSDTRHTPTGPSSNDSSSRLLDNRALYDLVPPEPQPLARILVDLRDTILSPPCTLTEGLFRRSTNSPLSSGLLSLSLLPSHSQSIIPWRTIAANDPLLPPKILHGLLSSFSSPIISEQLYPVIRKCDTPKDIETYLSPILTASENRILTYLADLISHLARHEETTRMTVKALAICLAPALLHGSDPMIDATMCLVPGQSLPPAMTQDRDLGQGAGTVVGMLMLWAEWSASNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Q8</accession>
    <name>A0A1Y1U9Q8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_634900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869012.1">
        <property type="nucleotide sequence ID" value="XM_022016771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Q8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Q8"/>
    <dbReference type="GeneID" id="33558580"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Q8"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="460" mass="49997" checksum="23967EB7AED2252A" modified="2017-08-30" version="1">MKRELSEGQEMSEGSSTPPLRALDAGSSQPTPPKRFKAEASPSIEGNGIDYRSLACREFGPSYNEWPAPARAILAAQKFIIEITTQQLPVLIAPDKDADGLSAGTLLHKTLLHLGLPETCIQVQHLQKGNNVHSAKEVERIAASGVSRVIVLDQGSRPGPPIFDPDEDGQARTLIIDHHYSHEWPDHSVVLTACHSPPIVTTSLLTYLLLRDLAPSFVKSEGWRALVGLIGDLGPNAAEWGQPPWPTELGRLSKRLGSKALADSVAAINAPRRTAEYDVPKAWKILLEANTPQAVASHAYLKLCKLDVGDETQKWARTAPKFSQDGRIALITISTGFQIHPVIATRWAGTLGRKSGKLVMVMCANTAYNPDGRVSFSCRIAATLRTLPDGERPNLIQLLLDIGHAIPGFMDRVGGDFARGHKEATGIGKPPSRKNENVKSPKKPRGADRSIRSFFEPVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Y2</accession>
    <name>A0A1Y1U9Y2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-lactamase superfamily domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_657709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869082.1">
        <property type="nucleotide sequence ID" value="XM_022018868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Y2"/>
    <dbReference type="GeneID" id="33560677"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Y2"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52540" checksum="662395BFD27B9B3F" modified="2017-08-30" version="1">MLSALMIRNCSAIVLTIVGAIMLALSVHVWRSVEPIHYQAQAFSFNIFVGAWTLSTEMVLLAFRYFGVNLNITTEMVVLLVSSILWLVSGDLTSQSRSGCSGSPQQGLAGVCSELQASFGFIWIAFTWFVILLGYLGFEMYRARSRDETQVWRKTLMELAERRSYDLESRSEDQATYVRKEREESPKMLYPFHLGAMKGRVWSLSRKDRQSLRRVAPFRMRQLLFFELGSDELRVLWIGHATVYLQCRGISILFDPVWSKRCSPCPLVGPKRGLDPPCRISDLPFVHIVVISHDHYKKSIQNIERHFVGVRYFVPLGLRRILEHFGVVEDRVVEMAWWEESIWHRTGMRTTISEPSEIILSACTGMAAGTPVIQRDGASDSVSIASSPTLVNEPSKTMEDREEAVNEKQEQLSYIRLVCTPAQHCSGRNPFKRNRTLWSSWFLELPRPGEEPWRIYFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAH2</accession>
    <name>A0A1Y1UAH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_583669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868807.1">
        <property type="nucleotide sequence ID" value="XM_022013631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAH2"/>
    <dbReference type="GeneID" id="33555439"/>
    <dbReference type="InParanoid" id="A0A1Y1UAH2"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="255" mass="28697" checksum="D29C40A1F201DBCC" modified="2017-08-30" version="1">MSLTSSPPALDPPFRGYIETTFDALLVFEAARRGMIPRVTRRLIERERGMVQSGAVFVFDEHESGIKRWTDGLVWSPSRILGNFLVYRETEKRSNQPPTPISSGHNTSPIQSSPSIDQNSRLEEPSAFGHGALPRPRSASDGGSNLDRQRERQLVGSLVNSSKFKDRGLVKKTMSVTVNGFAQHMISYYTMEDVMSGRLRSPSSIPELASLEISPEYLHKQNFRFPPMIEVGADGIPRYRWVFFSENQDSDFDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBB2</accession>
    <name>A0A1Y1UBB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_657311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869489.1">
        <property type="nucleotide sequence ID" value="XM_022018862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBB2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBB2"/>
    <dbReference type="GeneID" id="33560671"/>
    <dbReference type="InParanoid" id="A0A1Y1UBB2"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="358" mass="39797" checksum="2119F42E389441F5" modified="2017-08-30" version="1">MPRNTDLHRAYLQSMLSRRVLREEVGLELYKRAITAVRASDEDFEPTHQPTKDGFMSFLGDLNNTLEKYGMLLKRERDQTAKGRGWVVLVNTEANEVAMAGSDLTPNELAYLRDLLAEIVESYPANSIGSTRALKLAGEQQTKMAKTVAEALLESMVSRGWLAKSKRGRYSLGVRGLLELDPYLTSNFADLLRKCARCSKLLTIGWKCDNEEYSSQGDNHWHLACFEAVKRISRGSCPACRNSLEDVKPIGEAAVSVAQDTFINGSRGRKRKSGGRRVAEDASDEDEEQMNEEEDFEDEEGMASQSHDQSQSQNQSQSQEQSQTQTQPRRVSVSPCFPRGIAPDGFNSPPGPLGGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBF9</accession>
    <name>A0A1Y1UBF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869106.1">
        <property type="nucleotide sequence ID" value="XM_022018612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBF9"/>
    <dbReference type="GeneID" id="33560421"/>
    <dbReference type="InParanoid" id="A0A1Y1UBF9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="135" mass="15365" checksum="07378C8459ADB837" modified="2017-08-30" version="1">MLPMEYSVELRSAVSELLHPDPESWPSTAELFTRTHFASWIADAQRGEAKLQMEQRSLEQMRLKLERLMRSQTAKERALEAKEMSLEAEKRCLMLRASRSPPMATQTPQTASQTPAIKPEERAGAKATKAMRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBG7</accession>
    <name>A0A1Y1UBG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869571.1">
        <property type="nucleotide sequence ID" value="XM_022016535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBG7"/>
    <dbReference type="GeneID" id="33558344"/>
    <dbReference type="InParanoid" id="A0A1Y1UBG7"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="37365" checksum="6C9CE69AE019689F" modified="2017-08-30" version="1">MTVNDSEAWLEALDRDGYCVVPNVIPIQACKEYQDSAMTWLEGFGKGFKRDDPSTWSAEHLPRHFAGGMYSCHGVMHSAWVWKIRTQPGIQEVFKKVWGESDLVASFDACNISLPLGPQARKDIEPTKPWPHIDQSPELVHKRQEVQGIANLYPSGPNDGGLVVVKGSSKLHRQYFDEHGRFPFDANVDPKNVKERGMHFDYKELDWYLAHGAEIIKVCANEGDFILWDSRTIHWNRSPQGDQTRFATYVAYAPRKWMTEAELETKLEVFRKRIGTGHVATRNPDEKHNKDRDRWDLEDGAKSVPARPREEPEESPEIMWAVGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBM9</accession>
    <name>A0A1Y1UBM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869150.1">
        <property type="nucleotide sequence ID" value="XM_022018531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBM9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBM9"/>
    <dbReference type="GeneID" id="33560340"/>
    <dbReference type="InParanoid" id="A0A1Y1UBM9"/>
    <dbReference type="OrthoDB" id="2564652at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012033508" evidence="2">
        <location>
            <begin position="17"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="427" mass="42468" checksum="9C3929B477117A71" modified="2017-08-30" version="1">MLAITALLALTPIITALPVQERQLGGLLGGVLGEVTGLLSPVTSLLDPITAMLGINLDLTIGQSLTCNNVDGPFGGRNYSLGCTCANSAGGLLLEVDVDAIVNVAGLEAWVMAQVDLGLNFDYPAGAMPNCDGNGGYTCPGGNCAAVSSSQAPASSTPCPSDTPTSAPVSTTTTTTFEAAVVSSAEPSPQPPASSMEPSFSPPPTPTITPAPTQPQTFNVASAAPTSSYVDTEEPSDDGDDCEDDDPIVTNAVVVADTTITLSTVYVVETTITNTVTDTVTNTVTDTVTTTSVSTATVTETADCASSSTVNAAAVVSSPASPPPPPPASTSTPPPAPATTSTPPPAPATTTSPCPPSATSNVFIPAASPSPSAPSCPQGQKYDIELQICVDICVDALGLGLCAKADADVGVNLPVVNHLLGGLGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCB6</accession>
    <name>A0A1Y1UCB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_630945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869806.1">
        <property type="nucleotide sequence ID" value="XM_022016392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCB6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCB6"/>
    <dbReference type="GeneID" id="33558201"/>
    <dbReference type="InParanoid" id="A0A1Y1UCB6"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="443" mass="48361" checksum="8F832FD261F95437" modified="2017-08-30" version="1">MNVLGIWVETSSFTLFSRSFGIITSMLLLLLLGPRLNHPSSRKLVYFISNLLAGLSSVFFGLIPLLSPHAQPFAAVLLTIIATNSFIVAFMCFTSYLPIIARSVHQAHLDDFQKLPPTESDPLLSKPIEQAIAVEAPSGLSLTIAKINSVCGVIDCVISVGSSLLLQVVLRRTSLTPLTCISITGAWWMVISTISTIGLPGSAEAARAVDDQPVDPKPMKKQSTFQLLRSLKRLPQMRKLLGAHIIACDLIMIVPGVLFLYASTRLGLEVSDISVMMMCAYAGAGVWMPCQTWVQAKLHRTNLQMLIAGIILALLAPLWGSLSLVSSNLGILNKWHCWILSVIFGVASAIYETYSRSLLSEMTPHGHETSFASLYMLSSRSTSFMGNLILGFILQVTGKYDYAWVFFGAISIITLPIFLSLRVNEGVSEALEYETEESNNISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC4</accession>
    <name>A0A1Y1UCC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_634045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869362.1">
        <property type="nucleotide sequence ID" value="XM_022016696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCC4"/>
    <dbReference type="GeneID" id="33558505"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC4"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44710" checksum="E820F990204EDADC" modified="2017-08-30" version="1">MSTRSSGSSPQLTVHSHTSPTSFFTPTNIRFSDLSSDPSERTPTSEWNSRKARKGRYASRPATVRYITTKDGARGSRLEGYGTMIAQELNGRIKHEESKLKPNLKMDISWWVAVAFTFGSAVWVVNGYVEWFPLFRPNLDNQTVSRTAAALAFIGGTVFEIGSYLMVVEALDRGREINFGTAIGQLLHHRRHVDQEKDAEHHKLIQDHVLHHRERHSSSTTLSHAVNTDGGTEKNGKQSKVKPWIWWGPPMWHDMGYCAAVIQFFGATVFWIATITGLPGVIPGFAAGGGSIAIIDVFFWTPQVVGGTGFIISSTLLMLEVQGSWWRIKPLDIGWHVGFWNLIGSIGFTLCGALGFSSKSGVVYESDLATFWGSWAFLIGSCFQVWESIWREAEPEPDTKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCE3</accession>
    <name>A0A1Y1UCE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_581968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869882.1">
        <property type="nucleotide sequence ID" value="XM_022013533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCE3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCE3"/>
    <dbReference type="GeneID" id="33555341"/>
    <dbReference type="InParanoid" id="A0A1Y1UCE3"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="336"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="634" mass="71300" checksum="B334A4F4A0B61F6D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCN1</accession>
    <name>A0A1Y1UCN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_80738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869964.1">
        <property type="nucleotide sequence ID" value="XM_022019251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCN1"/>
    <dbReference type="GeneID" id="33561060"/>
    <dbReference type="InParanoid" id="A0A1Y1UCN1"/>
    <dbReference type="OrthoDB" id="2570648at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="472" mass="51460" checksum="CDE037D6FADBA40C" modified="2017-08-30" version="1">MTTSTTPTFARVSSLTHWTNLFHPVTGAFRLPSTAGEYIEHLDIDLRFVHCEFQDVGSLLGPKALEKTLLPSGPVHLPKVCLLTLRGAEHCQDCDESMEALAEVLGVIRPVEVRWLNASTDPREQVTFATHLVHDAIIQAGHQWAMHESLRKLVIQGGFPCPNLTAPTPFNLTPATTPASSPGPHRTTFGTLASALPSLSTIKPKAKVVDEDRLKARAERQRLAEYTLKPRFEFAFGSWGAESIHWRLDGRYTSTCIKSIAEQLFKALNKTWPHPATHSHLPLPSLFVFTPLDPLSVSKIRALPDALDLSSEMRDYIDDVFFFTAQFGAPMHARMFEQEDQVPVSDRSRQARRLKAEMILLHNGPNVIVELAQLIPSIPDSTNSSEAGTPPGTAKDQLVFRLDGSDSSPGSLPSIMTDHEGGVSSDEEDAVAMTPDLGTSLVMDEGAVTASDRGGGGCKSGPIPIRQGSWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCS9</accession>
    <name>A0A1Y1UCS9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_635401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869107.1">
        <property type="nucleotide sequence ID" value="XM_022016808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCS9"/>
    <dbReference type="GeneID" id="33558617"/>
    <dbReference type="InParanoid" id="A0A1Y1UCS9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="56" mass="6163" checksum="1DF0AC248FF1F52E" modified="2017-08-30" version="1">MINADTHDVEQMGRRLLKLLSTAGQMLCLACMVALFQHAARNHKIAKGSIVLLTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCW8</accession>
    <name>A0A1Y1UCW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_651779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869992.1">
        <property type="nucleotide sequence ID" value="XM_022018392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCW8"/>
    <dbReference type="GeneID" id="33560201"/>
    <dbReference type="InParanoid" id="A0A1Y1UCW8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="194" mass="22073" checksum="C373131D74A4286B" modified="2017-08-30" version="1">MSASTQEVLWLQSLWDDPTLDGQPLTDWHTIRTKHLGGDDPSLSMLLAAYRVNIVKFEQSITSILREPRPDTATLTANADETLRRSASLLQGLKSLQLTRDPGTIQIEAFHQLEQGARYLKWMLETKEASDAKNHKVDKYSRREDRRLIQGLVKAASEHATCLITNAGLTETEEWTEWSNKAKAWRRQASDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD26</accession>
    <name>A0A1Y1UD26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_581344</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870041.1">
        <property type="nucleotide sequence ID" value="XM_022013495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD26"/>
    <dbReference type="FunCoup" id="A0A1Y1UD26">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="GeneID" id="33555303"/>
    <dbReference type="InParanoid" id="A0A1Y1UD26"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="278" mass="30875" checksum="3D0331D6CE177E09" modified="2017-08-30" version="1" fragment="single">KINQVTGYDEVERLKKMVVDAENSLDESRQAARQAKEAYDSAVHSRSTAQQQVNNLLERKHSWTDTDVSAFTNLVRQDHSSSSNVTTTSAALRDAERRVDTAFSDLTRSILQRYHEEQVWSDKIRNVSTWVNMAGLIINLVVFLGAIAIVEPWKRKKLVQRVEERMAEMMNRVEGEVKEVARLVAPGVGPALIEQAVSDSEVQPIGTDTSLNVVEDTLDRQDKISSLPWLTTVFQTPEWRHAADLVGSHSIDTDLALAGGVCVTLGVVLGTIIATIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDD7</accession>
    <name>A0A1Y1UDD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870197.1">
        <property type="nucleotide sequence ID" value="XM_022016287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDD7"/>
    <dbReference type="GeneID" id="33558096"/>
    <dbReference type="InParanoid" id="A0A1Y1UDD7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="213" mass="22719" checksum="FFB8306EEBA983B7" modified="2017-08-30" version="1">MTTEEVSTPVAPIQPLPSLPHPSGLLGTSSTAYLTLNESRQGRESLDKFKQTLLDGGAGYNLDPPGPSHLPPLPSIPIPPKRHSKPSTSLPSKTPRPISRPRIPDESPFANASTVGDCIDAYGSSSVVVQNATLLVDLSSYGSAWIFLKQLPGPGDESKLQVECVKLYTGSDPNPPPLHSFSIEPPRRALGRSLTNLRLSLPELLVSPSCRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDK5</accession>
    <name>A0A1Y1UDK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_630256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870249.1">
        <property type="nucleotide sequence ID" value="XM_022016311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDK5"/>
    <dbReference type="FunCoup" id="A0A1Y1UDK5">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDK5"/>
    <dbReference type="GeneID" id="33558120"/>
    <dbReference type="InParanoid" id="A0A1Y1UDK5"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000025">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="45"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="215" mass="23569" checksum="DCB26E88FE14D39F" modified="2017-08-30" version="1">MPAARASTGSNSGSNPSRDYPSATAPTSRPASARTSTPNQSNTANSSLILRRQLLDLQKHPVDGFSAGLVDESNILEWQIVIIGPADTLYEGAILKARLIFPEEYPILPPRMVFDTEMWHPNVYNKGDKKGEVCVSILHQPGEDEWGYEDAGERWLPVHSVESVLISVISLLSADVPDLNSPANVDAAKEVREDFPGYKKKVKRLARKSAEEACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDX5</accession>
    <name>A0A1Y1UDX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAC3/GANP/Nin1/mts3/eIF-3 p25 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869475.1">
        <property type="nucleotide sequence ID" value="XM_022018492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDX5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDX5"/>
    <dbReference type="GeneID" id="33560301"/>
    <dbReference type="InParanoid" id="A0A1Y1UDX5"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48665" checksum="2B05B46241B24C2C" modified="2017-08-30" version="1">MQRYQPPHQRQRGSGIPHRSSAQAQSGSLNDNTVSSIRPLTEGEPFAPGLSASRSRHSHQTQHASASYRSKRDWTAPALASPASDLKPMRSSTPGRSGGSEGMNEMEMMQSVSRSGGDGAEGDALKDWTTQERYRAYIDERIAKHHAVFSTQPHSIPSKDSADELQSLKSIVLLLRKLREGVVASHRIDEFALEVFETSARISILARDGPQLISSLSGLIPGLYTTLDETKGKRRADDQPSTLENRLAGLKIGQRTSAATNAGSSDIISDSRVQFASVLLLYHLAHSNSYRTYHSTLISLTHPTQHRLRRPFHDLEPEVDAIRSRTSGNSPTRPFVSMKHLHFAASAARVLSEDSFDPVRYFALLSDSETSPYERAVLSWAEERVRDKAWTVMRRAYLECRVDWVGRWVGKMEERDVHDWLVSQNMAVVNGRVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDZ4</accession>
    <name>A0A1Y1UDZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_657206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869890.1">
        <property type="nucleotide sequence ID" value="XM_022018859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDZ4"/>
    <dbReference type="GeneID" id="33560668"/>
    <dbReference type="InParanoid" id="A0A1Y1UDZ4"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="68761" checksum="FD12B3D681227057" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEG9</accession>
    <name>A0A1Y1UEG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_651810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870025.1">
        <property type="nucleotide sequence ID" value="XM_022018395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEG9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEG9"/>
    <dbReference type="GeneID" id="33560204"/>
    <dbReference type="InParanoid" id="A0A1Y1UEG9"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="141" mass="14813" checksum="725A85EDDB3FD5F5" modified="2017-08-30" version="1">MHSGQCLCGATKIEINTTEEKQIACHCTDCQQTSGSAHSTNILPNQKDVKITGDVKEYNSKAASGNTVASLTANSDPTFCGTCGSALAHKSPAFGEGIAVQTGNLPDFRKIPFAAELFVKDRWTGLPEIPGADQAQAMPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEQ7</accession>
    <name>A0A1Y1UEQ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-4 methylsterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_629775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870115.1">
        <property type="nucleotide sequence ID" value="XM_022016253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEQ7"/>
    <dbReference type="FunCoup" id="A0A1Y1UEQ7">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEQ7"/>
    <dbReference type="GeneID" id="33558062"/>
    <dbReference type="InParanoid" id="A0A1Y1UEQ7"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="156"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="37536" checksum="F2228C09816C07DF" modified="2017-08-30" version="1">MASSTVMKAVDQFFPYLAPHLQIMNSTTAQNTLYGAVDWSQTSWLERKWAAYYVWIANPLIATGLLSFVWHEIIYFGRAFPFWVMDQIPYFNQWKIQETKLPSHAEYMHCLKTVLAIHFLIELPLIFAFHPICEYFGMATYEIPFSPVWKMAAQIAFFFVFEDTFHYWAHRWLHTPFMYKRVHKMHHKYQVPFGLAAEYAHPIETLILSQGTISGPFVYCLFAPKHSLHILTVYVWIALRLAQAIDAHSGFDFPWSLRQFMPFWAGADYHDSHHAVFKGNYATSFRWWDQMMGTDRWYKAQRASEAEKKLKAQQSKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEU1</accession>
    <name>A0A1Y1UEU1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870155.1">
        <property type="nucleotide sequence ID" value="XM_022018415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEU1"/>
    <dbReference type="GeneID" id="33560224"/>
    <dbReference type="InParanoid" id="A0A1Y1UEU1"/>
    <dbReference type="OrthoDB" id="2670688at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="900" mass="97828" checksum="229A156C1F3168CA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEU4</accession>
    <name>A0A1Y1UEU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_682194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022019140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEU4"/>
    <dbReference type="GeneID" id="33560949"/>
    <dbReference type="InParanoid" id="A0A1Y1UEU4"/>
    <dbReference type="Proteomes" id="UP000193218">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="173" mass="17866" checksum="F2C71D512BC517D0" modified="2017-08-30" version="1">MEAFGLPAAFGKASVPKTGKANDGPSRGTPSGRGPRGVVGGKRARGRGRGDKGDGGVSHLQTDEGLNTGVKVRKPDVYARLRSKRPHPHSANHGRTSDSGWGGRAEARAKGGLGTVTAFPPRGGRGGGRGGVYGARSGNSGESGNDSEGYFQPSFCEDPWKDLLKARERDAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1UF24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869839.1">
        <property type="nucleotide sequence ID" value="XM_022018460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF24"/>
    <dbReference type="GeneID" id="33560269"/>
    <dbReference type="InParanoid" id="A0A1Y1UF24"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="148" mass="16887" checksum="5A85BB0E258DB461" modified="2017-08-30" version="1">MSPDKTFTLSAIILLPFTDLESSFGHTRGVIIKGRMTDRQSLKIFIDPSLHYSINSLCNTHVDMSLVRNILIARMKSTTFTRDFCLSKDEWYRVAAGSIAILAWFGLSLFFWMRWSDRLNALHETEALAAAEKDQPRTVDAVAEETQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF48</accession>
    <name>A0A1Y1UF48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_525488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870255.1">
        <property type="nucleotide sequence ID" value="XM_022012996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF48"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF48"/>
    <dbReference type="GeneID" id="33554804"/>
    <dbReference type="InParanoid" id="A0A1Y1UF48"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09326">
        <property type="entry name" value="LIM_CRP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="227" mass="25296" checksum="88392256AAE97F8C" modified="2017-08-30" version="1">MFGAAPPCTTCGKSVYHVEQVFGPGKKVYHKPCLKCKQCNKRLDPGGLVDHDLDPYCKHCHLQLFGTRDLRHSNLHPASPASTPSKTPARRPLPTTPSNTTAMSPMSPKHPTPRNLPPPADYYTPPQLSSSSVPATPDYPRDPCTPITRPNFQDARPISVPYSGKRENLDERGLLRRGDSPRIKVGEKVNMGDEFCWGCEKRVYIAEQVREPLLDMTDEQIFALGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFG4</accession>
    <name>A0A1Y1UFG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_581063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870368.1">
        <property type="nucleotide sequence ID" value="XM_022013481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFG4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFG4"/>
    <dbReference type="GeneID" id="33555289"/>
    <dbReference type="InParanoid" id="A0A1Y1UFG4"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="272" mass="31145" checksum="262E0F7A8A0BFD8E" modified="2017-08-30" version="1">MDWEGEVKAHPDEPIELPVAVKRETGDEDANSERCVICLMALRDRTIVGVCGHEFCFECIGVWANQSRRCPLCSTDMSAFLLHDLDSSTPTKFYLPPLPQKKVPSLSLPGPSRRPILPEERLRMQAEKQELDELDLQVERRKEIYEHELYVKHIASNPTTRFRPNPTPRQIADNPELTQKATAFLRRELRVWSLVDVEFLTTHILSLLKAIDIRSEPAVRLLSEILDTPNGPRYPHGAEHFAHEIYSFLRSPFKELYKYDEAVQVSTSLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFH5</accession>
    <name>A0A1Y1UFH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_681543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870847.1">
        <property type="nucleotide sequence ID" value="XM_022019125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFH5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFH5"/>
    <dbReference type="GeneID" id="33560934"/>
    <dbReference type="InParanoid" id="A0A1Y1UFH5"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="238" mass="26701" checksum="370EF5C5D4E0E6FD" modified="2017-08-30" version="1">MMADSDPSESIAGLLKTLPELEQAFEAVLSRPSWTETVDQMNPLDRAKLDILMAYAINDLVWMYLKVKGVDPASHDVSTELDRIKTYYGKIRAAEEPKAQPSRKIDVPAANRFISSAIPKSQKEHHASTSAQAMAQSQAKRAVEEAESIERTGMDRRFRFVAETGQRLENDEDGEDEEPGGDDDEEMESDEGNHPQHIVFDDDGEPVSQHSGDQQDTNTATDEEPKPKRRRKRAEDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFK3</accession>
    <name>A0A1Y1UFK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_627222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870877.1">
        <property type="nucleotide sequence ID" value="XM_022015978.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFK3"/>
    <dbReference type="GeneID" id="33557787"/>
    <dbReference type="InParanoid" id="A0A1Y1UFK3"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012982699" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1062"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="929"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1313" mass="142336" checksum="14F4C92CAC2FB3DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFM4</accession>
    <name>A0A1Y1UFM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870415.1">
        <property type="nucleotide sequence ID" value="XM_022016108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFM4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFM4"/>
    <dbReference type="GeneID" id="33557917"/>
    <dbReference type="InParanoid" id="A0A1Y1UFM4"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="471" mass="51603" checksum="9078EA978A94ECDA" modified="2017-08-30" version="1">MMGDKSITALRAFCRGPSRMTTRVLSARTVPAGPRRTAVIEPMARFNSTLSGPPPDAGRKSRIKVHPIFWVAIGTILLYPTYMIVDYLASARTYPPAVRKPLREAVRHRYYGEIEEAEENFQKALEISLGLPASDFGPDALIKLSGLFAEYAKLLETSGQSFRAYRKLIEALDLFGPHALSANPLERISGEWSGCQPLSQEDHLRVIALHQKLGQLALQLATSARVYPYPRDLSATVQSGPTSFMDAAEYHLSSAVTALLRIGLATAPQSAEKSKNEEPVVVGRDLQLPSGSSSQLEGLIDRQGLGITMEALAEVYARKGQFEYAQQLLLQAISTLLPPNETKPLPRDRCQAAMLMTSISGHSHQSTSKDARKISRSWAVRAIELTNGAMEDAKGALDEESAKQICGRAASVALFNLGMMAELDSDIPKALDRFSKSLARAREIKFTQGEIQSSEAIKRIRYSKDGKWSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFX3</accession>
    <name>A0A1Y1UFX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_591370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871030.1">
        <property type="nucleotide sequence ID" value="XM_022013798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFX3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFX3"/>
    <dbReference type="GeneID" id="33555606"/>
    <dbReference type="InParanoid" id="A0A1Y1UFX3"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="7">
        <location>
            <begin position="645"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="723" mass="81076" checksum="BCE430E13BF6958E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFZ9</accession>
    <name>A0A1Y1UFZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_656992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870124.1">
        <property type="nucleotide sequence ID" value="XM_022018853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFZ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFZ9"/>
    <dbReference type="GeneID" id="33560662"/>
    <dbReference type="InParanoid" id="A0A1Y1UFZ9"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="311"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="770"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="882" mass="96466" checksum="23FA04C8C13C3559" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG09</accession>
    <name>A0A1Y1UG09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870545.1">
        <property type="nucleotide sequence ID" value="XM_022016152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG09"/>
    <dbReference type="GeneID" id="33557961"/>
    <dbReference type="InParanoid" id="A0A1Y1UG09"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011007302" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23101" checksum="B9D8380DF30EBA1F" modified="2017-08-30" version="1">MSVALCLLLAPLVVFGTAIPADFTRLLSTNSGDLATSDIVVPAPAKFTSPSDQNQVIATVGRGVQNYTCSGGSWVSIGAVASLYDIAPVVDFTHLPIQTISSMLPKMALKLLPFPTRVGPRVDIHHYFVNMPNTTAASPKFESATSSVILKKLDSVDAPNKATDVAWLQLEALPGQNGLASYVYRLYTSGGQPPSKCTVEGSLISVQYASMYFFTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG70</accession>
    <name>A0A1Y1UG70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_422777</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871081.1">
        <property type="nucleotide sequence ID" value="XM_022012738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG70"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG70"/>
    <dbReference type="GeneID" id="33554546"/>
    <dbReference type="InParanoid" id="A0A1Y1UG70"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="151" mass="16949" checksum="403F50C497E24F45" modified="2017-08-30" version="1">MSDIYSHTVELPKSQIPLSDLKDKTLLFVNVASKCGLTPQYKDLQALHEKYGEKGLVIIGFPCNQFKGQEPGTDDDVLQFCQANYGVTFPIAKKADVNGSDTQPIWKYLKEHADPPVQEIDWNFSKFLVKDGNIKWFPARSTKVSDVEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGC5</accession>
    <name>A0A1Y1UGC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SRF-type transcription factor (DNA-binding and dimerization domain)-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_579484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871067.1">
        <property type="nucleotide sequence ID" value="XM_022013380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGC5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGC5"/>
    <dbReference type="GeneID" id="33555188"/>
    <dbReference type="InParanoid" id="A0A1Y1UGC5"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="101" mass="11299" checksum="9751AEFDF15E374E" modified="2017-08-30" version="1" fragment="single">MRHNDVPGGFTYVDKDGESGRRKIRIEYIADKSRRHITFSKRKAGIMKKAYELSILTGTQVLLLVVSETGLVYTFTTTKLQPLVQNAEGKNLIQACLSAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGJ4</accession>
    <name>A0A1Y1UGJ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_626661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870716.1">
        <property type="nucleotide sequence ID" value="XM_022015919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGJ4"/>
    <dbReference type="GeneID" id="33557728"/>
    <dbReference type="InParanoid" id="A0A1Y1UGJ4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="323" mass="36883" checksum="5229E2BFCAF577BC" modified="2017-08-30" version="1">MTQSHITRLYEVQLNVQRREASRFQKLGKESRDIGDGRYLRMEPDFWSHTFTTSSFADEELQQALLGLCDAGTSFDYTSAMANLECLLCSRHHWILSPRDTVASRTTTLFEAVFRIYLSKHDGLEPVSNLTDEVVCELALPELLIMFIYGSPPSMPPMLLNVVDAIFKDSDFHHHSALHHALRLLRGFLMSRMRMEDTCPAPVFAQWQLRQVALFRLNGNRLSLNTIDVHAQLADITYPRPAFWRRCLLKGILGTEDPPLPVRDLATAVMIGNREEEFINVSSLSRPPLGLGSGELDYPFDISDSWHATLWGFVYVSFRSFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH45</accession>
    <name>A0A1Y1UH45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870883.1">
        <property type="nucleotide sequence ID" value="XM_022018306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH45"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH45"/>
    <dbReference type="GeneID" id="33560115"/>
    <dbReference type="InParanoid" id="A0A1Y1UH45"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="145" mass="15922" checksum="B755659243B5B5AE" modified="2017-08-30" version="1">MQSGTAAAASSSKKNTVYVAGFPDEVKEQQLLDAFVTFGDILEITLPSEPNEPEKHRGYAFLTFANPADAQDAIDNYDLNELPAYKGQGKFLKCSLAQPNRFGNEAKGDKFDRPVWESEEWLQKYDKAGAGGKGDGEEQAVPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH75</accession>
    <name>A0A1Y1UH75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl CoA binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_626078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871448.1">
        <property type="nucleotide sequence ID" value="XM_022015869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH75"/>
    <dbReference type="FunCoup" id="A0A1Y1UH75">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH75"/>
    <dbReference type="GeneID" id="33557678"/>
    <dbReference type="InParanoid" id="A0A1Y1UH75"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="13961" checksum="FE8B5446923BDE49" modified="2017-08-30" version="1">MSNTQAQFDKAVEIVGKLPPDGPAKPTTEDQLKFYAHFKQAKNGDCTGAAPGMFDFKGKAKYNAWKELEGMSKEDAMSIYVVLLRDMLKKFDDDEASKKFLAELEGASQKQWNSSMKAADGTQAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHY7</accession>
    <name>A0A1Y1UHY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_425128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871132.1">
        <property type="nucleotide sequence ID" value="XM_022012744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHY7"/>
    <dbReference type="GeneID" id="33554552"/>
    <dbReference type="InParanoid" id="A0A1Y1UHY7"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="117" mass="13075" checksum="B7D52AC583E67FD1" modified="2017-08-30" version="1">MSGAQFVEGRCNCGAYTIKTRLPERMNICHCIDCRRWAGAFYSAHIFTQEGEYTFTGPEPRTHTVKGQDGMDMQRAWCDTCGWIDDSNNGQLLSVKFSPACRAIPMSPGSLVMQNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI32</accession>
    <name>A0A1Y1UI32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_624944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871184.1">
        <property type="nucleotide sequence ID" value="XM_022015753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI32"/>
    <dbReference type="GeneID" id="33557562"/>
    <dbReference type="InParanoid" id="A0A1Y1UI32"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="218" mass="23402" checksum="098D02AAE49FC955" modified="2017-08-30" version="1">MSGKRTPPEAQSDPRGHPALSTPPKALEDAGTPHPASAPGSNDSASKPSSSSPSSSSSSSSGLKMPSLRPKPNGSANGAGTSSYSSIAANFYPRHAGGPPPTGPLARKVSAAEAETYFKNTPPMLGMTKWSKWIGMFGWATIFGVATYGVLFSYEGGREHVFSPIRRQVFGIWHRLNGTYDPVAAQAELDKRDEDLAWYEQKRVEQLEDRKKKGVYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI35</accession>
    <name>A0A1Y1UI35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_627060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870824.1">
        <property type="nucleotide sequence ID" value="XM_022015958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI35"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI35"/>
    <dbReference type="GeneID" id="33557767"/>
    <dbReference type="InParanoid" id="A0A1Y1UI35"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF18">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="473"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1171" mass="124352" checksum="E02C302B2F8A9EE2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UID7</accession>
    <name>A0A1Y1UID7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_625649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871345.1">
        <property type="nucleotide sequence ID" value="XM_022015820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UID7"/>
    <dbReference type="FunCoup" id="A0A1Y1UID7">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UID7"/>
    <dbReference type="GeneID" id="33557629"/>
    <dbReference type="InParanoid" id="A0A1Y1UID7"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="70"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="219"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="345" mass="37851" checksum="6A6FB6FA0A3C6D50" modified="2017-08-30" version="1">MVLLPRQSRLPACKGRAFSTSSYNQNSVPLLISPKQLKELPKNSTIPLDVSWHMPNNPRSALADYLAGPRIPNARRWDLDEVAELDPRKNPLSLTHMLPSKELFAEACGKRGISRDTHVVIYDTLGIFSSPRGLFTFKAFGHENVSVLDGGLPRWIAEGNDVELGDVPNHGEVEYTGATEPEPGFVRAYDEVVKNAQKPSSDPSSKPLLDHRPTPRWEGSAPEPRPGLPSGHIPNSRSTPFSSYLVPMSDKRPYTSYRPVEELRSVLVDGVGGTESWEKLKSGDGEIIFSCGSGMTAGIGWLAMEMVKHESGEQIRGSLYDESWTGYAVRPESAIATNKGSRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIE0</accession>
    <name>A0A1Y1UIE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_625419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871292.1">
        <property type="nucleotide sequence ID" value="XM_022015798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIE0"/>
    <dbReference type="FunCoup" id="A0A1Y1UIE0">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIE0"/>
    <dbReference type="GeneID" id="33557607"/>
    <dbReference type="InParanoid" id="A0A1Y1UIE0"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX37254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="210" mass="23939" checksum="0C8CA7147106EBF7" modified="2017-08-30" version="1">MTLYYTLCFGLLMSELLLFTTIICPMPFAMRKKMFHFLSENPVVAKVQYALKITFIFVAVLFIDALQRMVRIAQEGAGAKMKNEMPDVRTETNYAARKFYAQRNLYLTGATLFLSLILSRVFYIILDFIHVQENYSTLQQRTAKASGAAGESEELRKRIKELEAQVESGKAQGRDFDNLKKQAAQQNAEYNRLADEHAKATGSTSNKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU5</accession>
    <name>A0A1Y1UIU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_411914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871965.1">
        <property type="nucleotide sequence ID" value="XM_022012711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIU5"/>
    <dbReference type="GeneID" id="33554519"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU5"/>
    <dbReference type="OrthoDB" id="2595509at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="51" mass="5879" checksum="55A12C48D6233120" modified="2017-08-30" version="1">MSHFRRNQGRFSANTASEAYQRQLATPVHKWKKAWVSPTGLQPESSYKVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIX5</accession>
    <name>A0A1Y1UIX5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_579205</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871997.1">
        <property type="nucleotide sequence ID" value="XM_022013361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIX5"/>
    <dbReference type="FunCoup" id="A0A1Y1UIX5">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIX5"/>
    <dbReference type="GeneID" id="33555169"/>
    <dbReference type="InParanoid" id="A0A1Y1UIX5"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="92"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="303"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX38010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="484" mass="52477" checksum="DF6C5DC9A60F0F44" modified="2017-08-30" version="1">MKKEKLDKHSQDGKDVTGGKGDKKTAGPGPSSSTGPSPLTAQDKKYLSENSITLLPPLYPPALSIPSLPINSSLLNFLSKFERPTPIQACTWSALLDGRDVVGIAETGSGKTLSFAIPALHRKGKISGSGEGGKIQVLVLAPTRELAQQSHETFLEAGAKVNIKSTCIFGGVGKDGQYKDLRDPNVRVVVGTPGRTLDLADAGDLDLSNVNYLVLDEADRMLDQGFENDIRRIIAHCPGSESRQTVMFSATWPESVRRLASSFLRDPIRVTVGSDELSANKRIEQIVEVLDDNRQKDARMLHHLKAHLKAHPSSAASPTRILVFALYKKEAQRLEYTIGRAGYTIAGLHGDLSQDARFKALDKFKSGQVNVLVATDVAARGLDIPDVGLVLNVTFPLTTEDFVHRCGRTGRAGKSGRAVTFFTGEGHEKALAGELMRVLRDAGAEIPQEMNRFPTTIKKKEHGSYGAFYKNISDAPAPTKIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ99</accession>
    <name>A0A1Y1UJ99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_417835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872036.1">
        <property type="nucleotide sequence ID" value="XM_022012728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ99"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ99">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ99"/>
    <dbReference type="GeneID" id="33554536"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ99"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="517" mass="57726" checksum="614AFF3DF65430ED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJB9</accession>
    <name>A0A1Y1UJB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reactive mitochondrial oxygen species modulator 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_622691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871624.1">
        <property type="nucleotide sequence ID" value="XM_022015503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJB9"/>
    <dbReference type="FunCoup" id="A0A1Y1UJB9">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJB9"/>
    <dbReference type="GeneID" id="33557312"/>
    <dbReference type="InParanoid" id="A0A1Y1UJB9"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="113" mass="12147" checksum="DAD6EC7423742C45" modified="2017-08-30" version="1">MPPPRQVVEGGSTFDKMKMGALMGTGVGLTIGLIFGLTSIIRAGPGPRGTVATLSQYMLSSAATFGFFMSIGSVIRTESKYSALQYAQTPASLAWARMAQRQKVEIEVKEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJX7</accession>
    <name>A0A1Y1UJX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872292.1">
        <property type="nucleotide sequence ID" value="XM_022015302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJX7"/>
    <dbReference type="FunCoup" id="A0A1Y1UJX7">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJX7"/>
    <dbReference type="GeneID" id="33557110"/>
    <dbReference type="InParanoid" id="A0A1Y1UJX7"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="101" mass="11051" checksum="E51C874C0283A1C6" modified="2017-08-30" version="1">MAAADETAELGGTGSTMSIDKRLEEKLRSNLKIDHFDIVDTSGNCGSSFAITVVSPDFAKRMTLARHKMVNQILADEIKALHAFSQKTLTPEQWAAEKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK38</accession>
    <name>A0A1Y1UK38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_355283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872340.1">
        <property type="nucleotide sequence ID" value="XM_022012569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK38"/>
    <dbReference type="GeneID" id="33554377"/>
    <dbReference type="InParanoid" id="A0A1Y1UK38"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="401" mass="43193" checksum="C16B982BE20012D9" modified="2017-08-30" version="1">MMSLSAPFFPPTPTFKTLHDLQTPHTPRTPSLPLPQSSPFLDPFSNNTYSSPRLSPSPSPRPCSLKRSSTWSLLSSSPTDLGSPSKVDRDFIKTAYVASRSGANLIQILDIEGSSPPSFGTESDDTMGDHHSVTNGIENRSNLQPRQGTDHPLSSRAPSSTPVDSAFPGHEVRDQHGSAKHIRPTETTTSASIIHAHPSHRSSIGSAPSRGSSRGRSSTRRTTPLNDKSFLRLSMTTASMSEFTPSSHITSTGSTVEEEMELSSRRSSAGTFGRARRWSVSTGSLVDREVSGTFRGAKEASETFLSDDELGPGDHDDESMTSSQRRRRRRHQSASSSSASGGPSGPMSADAIAIHNSKGLFPSPTQPKKTHRKPESDAAITAHLLRTASELRNAIEERTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKB6</accession>
    <name>A0A1Y1UKB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_385134</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871552.1">
        <property type="nucleotide sequence ID" value="XM_022012642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKB6"/>
    <dbReference type="FunCoup" id="A0A1Y1UKB6">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKB6"/>
    <dbReference type="GeneID" id="33554450"/>
    <dbReference type="InParanoid" id="A0A1Y1UKB6"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 10 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="13">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="472"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX37565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="759" mass="82255" checksum="C7F264655A14234F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKG8</accession>
    <name>A0A1Y1UKG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_641616</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872394.1">
        <property type="nucleotide sequence ID" value="XM_022017432.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UKG8">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKG8"/>
    <dbReference type="GeneID" id="33559241"/>
    <dbReference type="InParanoid" id="A0A1Y1UKG8"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="15">
        <location>
            <begin position="746"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="14">
        <location>
            <begin position="1369"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="16">
        <location>
            <begin position="1630"/>
            <end position="1662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX38472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1662" mass="185773" checksum="843EA7B986E34F2B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKK4</accession>
    <name>A0A1Y1UKK4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_578323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871642.1">
        <property type="nucleotide sequence ID" value="XM_022013314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKK4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKK4"/>
    <dbReference type="GeneID" id="33555122"/>
    <dbReference type="InParanoid" id="A0A1Y1UKK4"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="57"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="247" mass="27154" checksum="152C4953DFD8CCBC" modified="2017-08-30" version="1">MSSGLPKTWTNSSGHEGRYRRKVGFEAFEPDSDALFAYTCQAKSEGYKRSRNTRVFAVAVSPDESGEDALDWLMTELVEDGDEIVAIRVIDIDEGEKTDPAQQDEFREEAQTMLSNILDKNNEADGRKLSIIVEMVAGGVTKTLLKMIALYRPDSMIVGTKGSRTRLQKWGMAMGAPGMGSVSRYVVSHSPVPVIVVRPERKVKKTLAKRQNNPKRGQYAALIGPDGALSLSRSRSRGSIGGLSDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKT1</accession>
    <name>A0A1Y1UKT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_369078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872521.1">
        <property type="nucleotide sequence ID" value="XM_022012601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKT1"/>
    <dbReference type="GeneID" id="33554409"/>
    <dbReference type="InParanoid" id="A0A1Y1UKT1"/>
    <dbReference type="OrthoDB" id="2575338at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="755" mass="80155" checksum="75F09BC8A5856534" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL60</accession>
    <name>A0A1Y1UL60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_623489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871822.1">
        <property type="nucleotide sequence ID" value="XM_022015587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL60"/>
    <dbReference type="FunCoup" id="A0A1Y1UL60">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL60"/>
    <dbReference type="GeneID" id="33557396"/>
    <dbReference type="InParanoid" id="A0A1Y1UL60"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="393"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="637" mass="69196" checksum="D1E156A2D7DED403" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULL6</accession>
    <name>A0A1Y1ULL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872811.1">
        <property type="nucleotide sequence ID" value="XM_022017928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULL6"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULL6"/>
    <dbReference type="GeneID" id="33559737"/>
    <dbReference type="InParanoid" id="A0A1Y1ULL6"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="157"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="599" mass="68882" checksum="A04A15AAF25EC4EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULN5</accession>
    <name>A0A1Y1ULN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_618007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872826.1">
        <property type="nucleotide sequence ID" value="XM_022014980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULN5"/>
    <dbReference type="GeneID" id="33556788"/>
    <dbReference type="InParanoid" id="A0A1Y1ULN5"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="142"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="296" mass="32794" checksum="6EBD9B22BACFFD94" modified="2017-08-30" version="1">MTIGPALPPHLAHLAQQQRSASPEGSAETGPSLPRSTTPVDEDAGDDFGPALPPHLAAKRKAQAVAVSGPSRPGPSISVGPSRPIYDDDSDDDVVGPMPTGDVGVEKSAVQEFMEREERRAKEREEAAKPQKLERQEWMLLPPSSGVLSAVDPLRKRPTTFSRSTEAKETDSTAWTETPADRAQRVADEVAGIKRKRLPDVGKGRDDEETGLRRERDLEIRREVERHNKEQRGKSLLDQHASKPKEEAEKSAIWDHDRDMGITGRLLSDQERQNKIREARGLNDRFGHSKRGAYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULQ1</accession>
    <name>A0A1Y1ULQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_354460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872328.1">
        <property type="nucleotide sequence ID" value="XM_022012565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULQ1"/>
    <dbReference type="GeneID" id="33554373"/>
    <dbReference type="InParanoid" id="A0A1Y1ULQ1"/>
    <dbReference type="OrthoDB" id="2561403at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="203" mass="23040" checksum="21B7F612F71EFC86" modified="2017-08-30" version="1">MPHETPTDIYLDLAVEQLVFTAFMQLARYAEIRRCVLKLRELGKPDTGIKARQQISQPGKIRNTWHQLRTAAFMIKQCTASQLRTAFAGGPGRGKVKKNLYPITLLDPGVFDKLPPDMRASFDLMMGATGGWVQPFLSGFSNSNIDLRYDSCLAEEDGEDWFHPALARYSLYPSDFRYVPDTKQIELNKLYGGIRCPSVEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM21</accession>
    <name>A0A1Y1UM21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_310731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872963.1">
        <property type="nucleotide sequence ID" value="XM_022012455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM21"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM21"/>
    <dbReference type="GeneID" id="33554263"/>
    <dbReference type="InParanoid" id="A0A1Y1UM21"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="577" mass="63915" checksum="0F3F87B19F881472" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM34</accession>
    <name>A0A1Y1UM34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_618546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872973.1">
        <property type="nucleotide sequence ID" value="XM_022015045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM34"/>
    <dbReference type="FunCoup" id="A0A1Y1UM34">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM34"/>
    <dbReference type="GeneID" id="33556853"/>
    <dbReference type="InParanoid" id="A0A1Y1UM34"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="74"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="514" mass="55908" checksum="22DD57320A090FE4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM44</accession>
    <name>A0A1Y1UM44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_311987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872983.1">
        <property type="nucleotide sequence ID" value="XM_022012459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM44"/>
    <dbReference type="GeneID" id="33554267"/>
    <dbReference type="InParanoid" id="A0A1Y1UM44"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="482" mass="52416" checksum="A4DC89E9DF650FB5" modified="2017-08-30" version="1">MSYSVMDPGVTRITRSFSLSESRNMPRYDASDHIRSGSRRQGQISLDDLDGPVGWSGSSSLETQEDQTQHRGRRRLLHRRLAREASVTVRDGSDCIPVLLSSSPLASPVLVSPWSPCSTSEGGVMVNKNSNCSGSNTGVHPKLVPHYARDASLKRSLSFGTRSMHIGLDDEDDDRKDKHDDEDYEWNDSIERRLDRGRLAWIPSSAGPTLPLFHDASGRPRRLRRSQSVCGLGFDVEKTLLVPQPRSSIISTTTTPSTPLQATGLSRSLSTSGVPLKTHHSTPPRRQTRHTTLPLTHWSSPKLDHSPTLPPVHTSSEANTVPNTPSSTATPDSPVLVTPDSKDIVDTPRPILSSRTSPRVSLLHTRGCPRPPPSSPPPIAPLPSTPLTDPLGPVAPQRQSRASTVNTSFELTTTTAAAPLSNAEENEEKGHSENNSDQSPRDITDTGNEKSLMSLEQVQRVQAHGKCATNGVEVRSPAMYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM60</accession>
    <name>A0A1Y1UM60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_587922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872952.1">
        <property type="nucleotide sequence ID" value="XM_022013759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM60"/>
    <dbReference type="FunCoup" id="A0A1Y1UM60">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM60"/>
    <dbReference type="GeneID" id="33555567"/>
    <dbReference type="InParanoid" id="A0A1Y1UM60"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="307"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119634" checksum="CB7D7101CCDD053B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMB1</accession>
    <name>A0A1Y1UMB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_369724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872538.1">
        <property type="nucleotide sequence ID" value="XM_022012605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMB1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMB1"/>
    <dbReference type="GeneID" id="33554413"/>
    <dbReference type="InParanoid" id="A0A1Y1UMB1"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="170" mass="18435" checksum="30173502CB111868" modified="2017-08-30" version="1">MIQRTFPSSSPIQPVYEFVRTSLDPSASTKPFVLWQPPRFHYPEHPIPAKKENPHKAHIIAPASYGNIKGGPTQGLQGGTGGKESLSHLGLVPQSVLLIKWTEDKMNASGYKAPLRSDLLEKIVPLPPAQPKEEMSTKPSPASASATGAGNSTGEKKIPKWLQKGLLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMF4</accession>
    <name>A0A1Y1UMF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873094.1">
        <property type="nucleotide sequence ID" value="XM_022015098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMF4"/>
    <dbReference type="GeneID" id="33556906"/>
    <dbReference type="InParanoid" id="A0A1Y1UMF4"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="388" mass="42846" checksum="16CF9DCEDF8B0CD7" modified="2017-08-30" version="1">MSYASASTQQPAAICALKSPADAIHILEAVRVGLVPRVTRRLTGQERSMIRPGTVWVWEEEETNMRRWTDGRRWGASRVGGGGFLVYTETNENMSPPTSHDMYGDYRRSAREPLIKQTYSTTMSNPATRKQKKFHVVAYSSKHNPQGDAHNPLPLPHQLPLLASLTITPGIWPEWEHRRDEASPTASTSRRGAPPQSYPQPSPYEYPQQPPPRPQERYHPYHDARGPRSPFQQAQIASVAVPPPLPTDGWVQDRGYVYPEYPPRGPAAVGYEDYRHHSRSPDRRTYQSHSRQESAPLVSQGVPQPVVAVAAAAAADEFGMTNRHSSPKMSIGNSLNHREVTLPPLRAAIEGDGGADVVTNGAGLGGADGTSPSEDKRQLDELGRKIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMJ9</accession>
    <name>A0A1Y1UMJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_619127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873146.1">
        <property type="nucleotide sequence ID" value="XM_022015125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMJ9"/>
    <dbReference type="FunCoup" id="A0A1Y1UMJ9">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMJ9"/>
    <dbReference type="GeneID" id="33556933"/>
    <dbReference type="InParanoid" id="A0A1Y1UMJ9"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="82" mass="9558" checksum="EAC3ED9148296A82" modified="2017-08-30" version="1">MPRVYLLSRTLDPLFGVFSGLLAYHLSESHPRSNIPPGHTLRELVPWQFNRWRAARHAGSEGEEEMFERTLRELQEDKVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMP4</accession>
    <name>A0A1Y1UMP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sds3-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_619272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873194.1">
        <property type="nucleotide sequence ID" value="XM_022015156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMP4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMP4"/>
    <dbReference type="GeneID" id="33556964"/>
    <dbReference type="InParanoid" id="A0A1Y1UMP4"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39301" checksum="C76DEA068885323D" modified="2017-08-30" version="1">MAKYLPPGTGPGPTIIPPQYAESKRDRKRRETINKIEMLHDESWRNRDEKFATLYKDYHNENRAVNSQPPTSSQYYLRLYPRTVERDALLESAEVDYQYKAGQAKRMYESERETIERQYWDARDQVRQRLLQAIEERRRKLREEKEGGDVVSETLLEAQIRPRPSRRMPFRNRLLSPYSRASTPALGGTSAPTNLINLNGSSSAPTPNGIQRDDLLLHTLLAPALAQISVDDIISSNASSLAVNPPPSGPMAFTNAGKRGPRGKMPDAANGDSKETPAAPGTLTALAIASGQQAPAPARGSRGAGAAATGQWVLGKSLAELKRMESASQLEIDSDWARIQGSTGRGRRNRGDGAAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNP5</accession>
    <name>A0A1Y1UNP5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_225530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873448.1">
        <property type="nucleotide sequence ID" value="XM_022012224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNP5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNP5"/>
    <dbReference type="GeneID" id="33554032"/>
    <dbReference type="InParanoid" id="A0A1Y1UNP5"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000063">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.20, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="401"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="606"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="943" mass="105504" checksum="BD17DFD108C33CE2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNU3</accession>
    <name>A0A1Y1UNU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative vacuolar protein sorting protein of the Sec1p/Munc-18 family,VpsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_576510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873488.1">
        <property type="nucleotide sequence ID" value="XM_022013192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNU3"/>
    <dbReference type="FunCoup" id="A0A1Y1UNU3">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNU3"/>
    <dbReference type="GeneID" id="33555000"/>
    <dbReference type="InParanoid" id="A0A1Y1UNU3"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="686" mass="75245" checksum="32D1900F71D09B35" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP87</accession>
    <name>A0A1Y1UP87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_615104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873604.1">
        <property type="nucleotide sequence ID" value="XM_022014683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP87"/>
    <dbReference type="GeneID" id="33556491"/>
    <dbReference type="InParanoid" id="A0A1Y1UP87"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="154" mass="17218" checksum="D58818CEBF00E4E7" modified="2017-08-30" version="1">MTVSPRLMENGRLCVGAELHPASGSPLRLPFRLAGSALRSTACDHTLRPSPSSSGRAIIIKFHFTLARTAGRSYPRCQIFPSGGASLVWCKEWGVHMRMPKRTSSVSALTGFCTKRRPGCKNGSILNLHLDRCPRDNKDEKRRKKWVHDADMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPA7</accession>
    <name>A0A1Y1UPA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_597443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873653.1">
        <property type="nucleotide sequence ID" value="XM_022013880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPA7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPA7"/>
    <dbReference type="GeneID" id="33555688"/>
    <dbReference type="InParanoid" id="A0A1Y1UPA7"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="60032" checksum="5B86748C13FCC980" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPC0</accession>
    <name>A0A1Y1UPC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_615365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873666.1">
        <property type="nucleotide sequence ID" value="XM_022014712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPC0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPC0"/>
    <dbReference type="GeneID" id="33556520"/>
    <dbReference type="InParanoid" id="A0A1Y1UPC0"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="688" mass="75247" checksum="641B8377788785DC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPH7</accession>
    <name>A0A1Y1UPH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_607707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873277.1">
        <property type="nucleotide sequence ID" value="XM_022014078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPH7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPH7"/>
    <dbReference type="GeneID" id="33555886"/>
    <dbReference type="InParanoid" id="A0A1Y1UPH7"/>
    <dbReference type="OrthoDB" id="2930561at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="495" mass="54755" checksum="7ADB063DF89B09AF" modified="2017-08-30" version="1">MSSSSSDVLPKDRKKSAHWSEQDTEILINVLLNHRDSSRTSDNGFKTEVWREISDLLEGTTVTGGPKTPEACKSRWQRLQRDYKAAKEMEAVPGFSWDHATSKLVASQADWDAVEKQWEAGKFQRLHIPLYNSIALLCPDEKIRGTITRPRKSIGSMSDASSMLSLSVSSAGPPHTPQLGMPPGHVLVGGSGMLNMPDPGYHWDGTDVDAEGEYDPNFMHDSSSFAMQSGGPKRPHYDAAMLNGPSTTTTPLDISRPPGPKRARSNPSLTHGRPTPMSYHIAMPPAGHLGGSPMPSPTGYAQGMLLDPALISPTTPVLMQQQQQHQQQQQHQAPPPPQQQQQQQPPPTLPPHRHMHTRSQLQMSSTPTESLPLKPLSSLTTHVQTPPQTMINRIPQTAPPPRHVLSPPFEVEPPRTVSTPEAHLTEAQRRTQAILQLQGESELKDEDVMEVMAEFESNPIAMDTYLALKRDSLRRMYLSNLIAKRIEASRVNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPH9</accession>
    <name>A0A1Y1UPH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_615541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873708.1">
        <property type="nucleotide sequence ID" value="XM_022014736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPH9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPH9"/>
    <dbReference type="GeneID" id="33556544"/>
    <dbReference type="InParanoid" id="A0A1Y1UPH9"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="719" mass="79772" checksum="79AE8221A598EABB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPJ5</accession>
    <name>A0A1Y1UPJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_597490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873677.1">
        <property type="nucleotide sequence ID" value="XM_022013882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPJ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPJ5"/>
    <dbReference type="GeneID" id="33555690"/>
    <dbReference type="InParanoid" id="A0A1Y1UPJ5"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="582"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="798" mass="85846" checksum="6BA72FE12DE9DF74" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPK6</accession>
    <name>A0A1Y1UPK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_576619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873307.1">
        <property type="nucleotide sequence ID" value="XM_022013199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPK6"/>
    <dbReference type="GeneID" id="33555007"/>
    <dbReference type="InParanoid" id="A0A1Y1UPK6"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012508198" evidence="2">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="420" mass="45617" checksum="496DDD686B828864" modified="2017-08-30" version="1">MTHRTLLVLGLLARWAEATHLRPSRIQQVWDVMNQISVYSWENGTRAEALLEYNYPSLSPISSSSPFPLPQNLNTDQFSQVYDLAHMTMQNRNSSTSTDSPFQGATLLPDGAAGDPASLGISVLLANVSTHNEQVNGIGYGDAAREELDYLLYDVPRTSSGAISHRADQAQLWSDSVYMVPPFLAYYGVLHNNQSLIQEAYTQCSLYRQALKTDNNLWMHIVDGSGFLDYGCWATGNGWAAAGMLRVLATIKYSQFSSAMQQQQSDLQSWIEEILTAASGYISKNGLLHNYINDTGTFEDAASSALFAATGYRLSTIGLTNAHVNMSSQLLSAVSSKVNSTGFVTQVVDPLSFGEQGKASPEAQSFLIMAYAAFNDWNSTGRAGSGDSDDDPLGNYGGATTIDRPVELIIALAALLWAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPL2</accession>
    <name>A0A1Y1UPL2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_679872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873269.1">
        <property type="nucleotide sequence ID" value="XM_022019056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPL2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPL2"/>
    <dbReference type="GeneID" id="33560865"/>
    <dbReference type="InParanoid" id="A0A1Y1UPL2"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="273"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="664" mass="73268" checksum="9974241B8E6C9932" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPS1</accession>
    <name>A0A1Y1UPS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_614187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873352.1">
        <property type="nucleotide sequence ID" value="XM_022014570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPS1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPS1"/>
    <dbReference type="GeneID" id="33556378"/>
    <dbReference type="InParanoid" id="A0A1Y1UPS1"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="495" mass="53631" checksum="CCEC9388942CA81D" modified="2017-08-30" version="1">MIFDPYGELVWSGANISGQTLSYNIFTYNGSQVIGVWTGQFEGSGYGMGYDLVLDTAYNTVATINSTLGSPTDFHELSITPDGTALVTVYDKVPYNLSSYGVVTDDPAGGAILQGQFEEIDIATGKGIFNWSSLDHVDPSMSYADPGTTGTDMSNAWDYFHINSIDKDGDGNYLVSSRHCHAIYKIDKTDGHIIWTLNGKNSSFALGNNTAFSWQHDARWRTDYTQMSIFDNAATAFESDAASSRGLLLNIDQSNMTASFALETYPYNYTTSDSQGSMILQPNGNWLMGWGQQPYVSEYDPSGNMLWSFQFGLGTTQSYRAFRSNWTAYPTTSPNISVESNSSSNAYDVYVSWNGATEVQMYHLYHSSSTDGKGLNWLQTANKTGFETWLSVPMSSAAQSDYFQIVAANSANKTLGYTDFMSTDGTTRSPATSSESSSVVSQSPSQTSSVSPSSSSSSTKTGAASKRSFLSAWTRSGLTFGVLVVGMIMGSAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ93</accession>
    <name>A0A1Y1UQ93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_614396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873411.1">
        <property type="nucleotide sequence ID" value="XM_022014591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ93"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ93"/>
    <dbReference type="GeneID" id="33556399"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ93"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="36618" checksum="1F4EBC2335AFE3D8" modified="2017-08-30" version="1">MSSYDPVPVSSSSGRRAVYQAPSHEGLITAEQFKESMRFVRMQIAVPISVLIAMGANLVCALALKPGLAGINVRYPTLVSPNSIMIGLYWAVLYCLQVGFCLVLLLARKDVTKETLVYGVGIRFAVANWLLAAWAVSFTLQAFAVAEILILLNVVNLLTIHLTLLKYPPTMKRPLDTIFIHAPMALLLAILFEVDWVHNGFIALNWRIHDRSDRDDYTWQAVAFIASVNIVAALWEGIRRQYLMTGASIYLLFTLMFASPRGDPDLPSSALPKPTPVLVVSIACLVLHVVALIAGLAWKRMRDREGRIRLEEEVERMEREEYEARDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQA3</accession>
    <name>A0A1Y1UQA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRPBCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_616684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873964.1">
        <property type="nucleotide sequence ID" value="XM_022014848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQA3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQA3"/>
    <dbReference type="GeneID" id="33556656"/>
    <dbReference type="InParanoid" id="A0A1Y1UQA3"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18422" checksum="BC5E065C1F6D5C8A" modified="2017-08-30" version="1">MLSAETTINAPPHVVREVFLDFERIPTWHNQRPFFESIQVTGPSRLNGSECQKGDKMAVKIPGMNFTPTVQENEPENFRWLGSLPYILTGPHDFFFRPDPSGDANKTLFRQEENFTGLLSFMFDNPNSTRGKGTIEGWQRFNEDIKKEAERVWADKQGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQK0</accession>
    <name>A0A1Y1UQK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_237873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873612.1">
        <property type="nucleotide sequence ID" value="XM_022012248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQK0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQK0"/>
    <dbReference type="GeneID" id="33554056"/>
    <dbReference type="InParanoid" id="A0A1Y1UQK0"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="463"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="60050" checksum="3B44661A7E54D03E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQK7</accession>
    <name>A0A1Y1UQK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874108.1">
        <property type="nucleotide sequence ID" value="XM_022014911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQK7"/>
    <dbReference type="FunCoup" id="A0A1Y1UQK7">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="GeneID" id="33556719"/>
    <dbReference type="InParanoid" id="A0A1Y1UQK7"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="564" mass="61322" checksum="FC3CCB41C19DFE20" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR80</accession>
    <name>A0A1Y1UR80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_224985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873440.1">
        <property type="nucleotide sequence ID" value="XM_022012222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR80"/>
    <dbReference type="GeneID" id="33554030"/>
    <dbReference type="InParanoid" id="A0A1Y1UR80"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="207" mass="23435" checksum="0369AE019B6201B8" modified="2017-08-30" version="1">MADEDRRMTPVTLRRPRNIKVPPRHHVAAEHRTSSLWQLAASSRLVFAMHFEAYIKKLTIIHTATPGKDTVHQLLAFRQNDVLLSPEKNPAYSHRGSHKGGKELTEVKAVKGANLQTATQQELDRQAAILIESLGKAIGHGIDHFTREAVRRLQNHDCILIYDTITIKNPEAWEINKPIEFKTLRGFPQASIGHPEYALDLVVVRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URB9</accession>
    <name>A0A1Y1URB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_654414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874290.1">
        <property type="nucleotide sequence ID" value="XM_022018791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URB9"/>
    <dbReference type="STRING" id="4999.A0A1Y1URB9"/>
    <dbReference type="GeneID" id="33560600"/>
    <dbReference type="InParanoid" id="A0A1Y1URB9"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="4">
        <location>
            <begin position="633"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="690"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="83629" checksum="BA7CC60D2C1BC477" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URG5</accession>
    <name>A0A1Y1URG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATP-dependent rRNA helicase RRP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_596174</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874309.1">
        <property type="nucleotide sequence ID" value="XM_022013859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URG5"/>
    <dbReference type="FunCoup" id="A0A1Y1URG5">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URG5"/>
    <dbReference type="GeneID" id="33555667"/>
    <dbReference type="InParanoid" id="A0A1Y1URG5"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="70"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="264"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="427"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX40630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="486" mass="52738" checksum="67F957CA1FE9D98B" modified="2017-08-30" version="1">MSDSESEAGPSRSPSRSPDPSVDGSQSGANDSSVITTSRTFASLGVIPQLCESCAALGFKAPTEIQVESIPHALEGRDVIGLAQTGSGKTAAFSLPILQSLWEKPQPFFALILAPTRELAYQISQQVTALGSAIGVRAATIVGGMDMMSQSIALSKRPHIIVATPGRLMDHLENTKGFSLRGLKYLVMDEADRLLDMDFGPIIDKILKVIPKERNTYLFSATMTTKVAKLQRASLSKPVRVEVASKYSTVSTLLQHYLLLPLKHKDAHLLYLTNELSSSSMIIFTRTVHDAQRLSLILRRLGFPAIPLHGQMSQSMRLASLNKFKSGGRSVLVATDVASRGLDIPLVDLVINYDMPTNSKDYVHRVGRTARAGRAGKSITLVTQYDVEILQRIEAAIGKKMVSFDVDKEAVAVLSDTVAQANREAAIEMREQGTGGSGGKRGRDKGKRGRGWENDDQDRDDDVVQAGLPKKKKGNKFKSGPGKVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URV2</accession>
    <name>A0A1Y1URV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_612100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874462.1">
        <property type="nucleotide sequence ID" value="XM_022014350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URV2"/>
    <dbReference type="STRING" id="4999.A0A1Y1URV2"/>
    <dbReference type="GeneID" id="33556158"/>
    <dbReference type="InParanoid" id="A0A1Y1URV2"/>
    <dbReference type="OrthoDB" id="2575964at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="749" mass="79420" checksum="2BB998624DF2E491" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US33</accession>
    <name>A0A1Y1US33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_615863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873780.1">
        <property type="nucleotide sequence ID" value="XM_022014764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US33"/>
    <dbReference type="STRING" id="4999.A0A1Y1US33"/>
    <dbReference type="GeneID" id="33556572"/>
    <dbReference type="InParanoid" id="A0A1Y1US33"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="376" mass="41092" checksum="03E280F3ECECB908" modified="2017-08-30" version="1">MVYNLLLGGYGNHITYASFDPSTAKIKVHSNSKVPEAPSWIDPGVSSPKLKTPSGQAFYTIAEIEKGQAVSLDLVEEELKVTGTYDLQGSPAYVHTLKDGSGIVVGNYMGGNAHLIPTTSTYALDTSSTLKPLHFPYMYKDIEAPNPDRQDSSHPHQVIEGPNDQLFAPDLGSDRVWIVKRDNSTESGLKIVGHFQCPKGSGPRHGVVSVDEKHLYVLGELDQTIFSFKIADPSSLPIFHDNIAPPTVAPKYRKFLGAAELLNHPKYPGTLYASNRLEKHIKESDSSYDGEEVKGDAIAIVLLDESGTKVGHTSWVRTECDHIRGMMISPDGKFMALAGKDAGGVEIWQVGGEKGQEWKMAAKDESLKQVTTFVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USQ7</accession>
    <name>A0A1Y1USQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_613039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874732.1">
        <property type="nucleotide sequence ID" value="XM_022014464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USQ7"/>
    <dbReference type="FunCoup" id="A0A1Y1USQ7">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USQ7"/>
    <dbReference type="GeneID" id="33556272"/>
    <dbReference type="InParanoid" id="A0A1Y1USQ7"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX41053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="462" mass="52509" checksum="CDF559222DA8D991" modified="2017-08-30" version="1">MDHRPVLERTAIKAACHWLHSQMWTNWDEEEGSVLYKAVDRLGEGTFSSVFLARDLFHTKYDNEYWTGNKAQQVYTEYFGEDPTIRVALKKILVTSSPVRIENELSILESLRGSRNVSKLITAFRQDDQVIIVMSYHPCDDFRHFYRHMDVKHIRSYMRSLLRGLKEIHQRGIIHRDIKPANFLYDYATGQGAICDFGLAERYKPARRPTCQHSSASIRSSTSGKVRTAETPAVERAVYQARKRAKLGDGRVGFLGDDTRPSMKTNRAGTRGFRAPEVLLKCPDQSFAIDTWSAGIILLSILAQKFPIFNSTDDVEAMMEIAALFGRSALERCAMLHNRTLICNVPTLDADPQRTLKSIVLRLNPHLYTPPSSCPSSWEAEEHIRFIDHALRLLHGLLRLDCTSRFSASEALQHEFFSEEGEDMDQDFDDFEPVGIQDGKCGNLHGFVDGRRASYAVIASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USS6</accession>
    <name>A0A1Y1USS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_36571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874752.1">
        <property type="nucleotide sequence ID" value="XM_022012590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USS6"/>
    <dbReference type="STRING" id="4999.A0A1Y1USS6"/>
    <dbReference type="GeneID" id="33554398"/>
    <dbReference type="InParanoid" id="A0A1Y1USS6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="296" mass="31290" checksum="0ED9A606F49E0F63" modified="2017-08-30" version="1">MIDSTLSPRLSHLLIQEDSMTGRLLMPDGTDAREPMGGLSPPLTPSTSTFAFEASPLHKSARLPSPLEPNALFNSLRLPPPTALPYRRSQQSASLLSILSTSPPDSADSSFSFVRPASAGQRLAPPSSHSSRPMSSRAVPPSPPPTVFVARSASMRPSWSGPGQFGPSSFGSGLRPLTSAPLSSSFPNRPQGFVRRESVMSDIPPPTPYSRPNTSPYPMPSGAQRFHAGHGVEEGMGSRAPISRTTKACNACRTRKVRCDAGGLPGGQPGTCSRCRESGVDCVYSVIQKKRGPCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT30</accession>
    <name>A0A1Y1UT30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_613501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874852.1">
        <property type="nucleotide sequence ID" value="XM_022014503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT30"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT30"/>
    <dbReference type="GeneID" id="33556311"/>
    <dbReference type="InParanoid" id="A0A1Y1UT30"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX41173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="90" mass="10125" checksum="2CDCB679BA13CDF5" modified="2017-08-30" version="1">MSAIRAFRSARITSLRAPTVMFSTRGYADSTRPEGQTASSKGFSQREQAEEGQYIRKKEQEKLKEAQDKLKLAQDEVDKAQDAVNKSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTG9</accession>
    <name>A0A1Y1UTG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874931.1">
        <property type="nucleotide sequence ID" value="XM_022014538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTG9"/>
    <dbReference type="GeneID" id="33556346"/>
    <dbReference type="InParanoid" id="A0A1Y1UTG9"/>
    <dbReference type="OrthoDB" id="2579385at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012982706" evidence="1">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="201" mass="21670" checksum="7AA9A45BAC4A8573" modified="2017-08-30" version="1">MSLAVRAMALLASATAALAWYPCYDAPLTLAQLIGEPCCPDNLTAFHSFVQVHIANHSAYDVWRIVGNFEDLSWQGTTNITTTGIKNAPNNTHTQITPAGPATEELNIYVGPAYDPPSPTQSLFFMQFKDITLSALLDVYFIHLEDLLISRKDGNGSILSWESSGCTNTTSGATKLFNALHSHNLNNTVNILNGGTATSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTK4</accession>
    <name>A0A1Y1UTK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874971.1">
        <property type="nucleotide sequence ID" value="XM_022014552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTK4"/>
    <dbReference type="GeneID" id="33556360"/>
    <dbReference type="InParanoid" id="A0A1Y1UTK4"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1125" mass="123101" checksum="CA53624CE04E9170" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTL7</accession>
    <name>A0A1Y1UTL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAC1-like LisH-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874214.1">
        <property type="nucleotide sequence ID" value="XM_022014246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTL7"/>
    <dbReference type="GeneID" id="33556054"/>
    <dbReference type="InParanoid" id="A0A1Y1UTL7"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="74" mass="8050" checksum="8E475D0F453DCDE9" modified="2017-08-30" version="1">MATSKTVTLSKESQEGLHAAILAYLVEKGFTRSVKAFSKEATASSGGHAQSLMKAWENVNNNDAQRQRRRGQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTW1</accession>
    <name>A0A1Y1UTW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_575224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874736.1">
        <property type="nucleotide sequence ID" value="XM_022013113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTW1"/>
    <dbReference type="FunCoup" id="A0A1Y1UTW1">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTW1"/>
    <dbReference type="GeneID" id="33554921"/>
    <dbReference type="InParanoid" id="A0A1Y1UTW1"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX41057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="371" mass="42030" checksum="C18ADA22C508F13D" modified="2017-08-30" version="1">MGPDFLWMTTEEPHRSRRMAILKAHPEVRKLMGPTLYTPPLVAFVLAIQLSLAYTSRNTYPLSPLFLLAAYAIGGTCNQNIFLAIHEITHNLAFKGIKANKCLAIFANLTIGVPYAMAFKGYHIEHHRFLGEDGIDTDLPTRLEAVLLNNVAGKTFFATFQLLFYALRPGFIRTQKFTKWHAVNLAVVLSFDTLIVKTWGWYSLFYLLISSFFAGSLHPCAAHFIAEHYLMSGPVGIEGEDDIIGLGQETTSYYGPLNWLCYNVGYHNEHHDFPSIPWTRLPALRRLAKDFYEPLPCHKSWPYVTWKFITDPSIGMWCRAKRLESGEKISPKTWDTSVKTDPASDSEGSSSEEVDQEMAEAFERGYGSDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTZ2</accession>
    <name>A0A1Y1UTZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Electron carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_612855</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874683.1">
        <property type="nucleotide sequence ID" value="XM_022014449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTZ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UTZ2">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTZ2"/>
    <dbReference type="GeneID" id="33556257"/>
    <dbReference type="InParanoid" id="A0A1Y1UTZ2"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX41004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="111" mass="12119" checksum="A9775A0EDDE38A90" modified="2017-08-30" version="1">MAGDKFEKGDATKGASIFKTRCAQCHTLGKGEPNKVGPNLHGLFGRKTGQVDGFSYTAANVNKGIEWGNETLFEYLENPKKYIPGTKMAFAGLKKAKDRNDLIAHLEEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU23</accession>
    <name>A0A1Y1UU23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_586201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874713.1">
        <property type="nucleotide sequence ID" value="XM_022013742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU23"/>
    <dbReference type="FunCoup" id="A0A1Y1UU23">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UU23"/>
    <dbReference type="GeneID" id="33555550"/>
    <dbReference type="InParanoid" id="A0A1Y1UU23"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX41034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="483" mass="52051" checksum="738CC2F0EEFC10E6" modified="2017-08-30" version="1">MSFHRALAGSSRVPGRPAARILLQRTYASAKATAGKCHEATHPDECPPETADLMESHSRYLLNTYARPPLMFDRGSGLSLWDTSGREYLDFSAGIAVTGLGHSDEGFNKVLAEQSAKVSHISNLYWNKYAGELAKDLVEATRKHGGLGLSKEGGDGAKVFFANSGAEANEGALKFARKYGKDAAAAVAVSGKDKALDKSGIVCFTNAFHGRTMGAISCTPNPKYQAPFAPLIPNIRVGQYNDMDEKRMLELVDESVCGVIVEPIQGEGGVGTGKVEWLEMLGKRCRKVGAVLIFDEIQCGMFRTGEMWRHSSFPKDAQPDMVTTAKALGNGFPIGAILVRDHVAEVISIGSHGTTFGGQPLAVRMGHYVFSRLSEPSFVKSVNETAAHLDSLLEGLSKSFSSLITDEKRGKGFIRGIAFKDESHPAELVRLARERGLLLLTAGKDAVRLVPALIVTKEQCDKAVAIMESCLSIMQEKSTSKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUB2</accession>
    <name>A0A1Y1UUB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_606840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874906.1">
        <property type="nucleotide sequence ID" value="XM_022014031.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUB2"/>
    <dbReference type="GeneID" id="33555839"/>
    <dbReference type="InParanoid" id="A0A1Y1UUB2"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012395190" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="374"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="487"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="598"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="704"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="845"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="949"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1471"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1598" mass="164938" checksum="7E74D2B46A6098C4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUC6</accession>
    <name>A0A1Y1UUC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_613798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874926.1">
        <property type="nucleotide sequence ID" value="XM_022014536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUC6"/>
    <dbReference type="FunCoup" id="A0A1Y1UUC6">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUC6"/>
    <dbReference type="GeneID" id="33556344"/>
    <dbReference type="InParanoid" id="A0A1Y1UUC6"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX41247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="523" mass="56320" checksum="D708AA20AEF9B05D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5C6</accession>
    <name>A0A1Y1U5C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_650410</name>
        <name evidence="3" type="ORF">BD324DRAFT_654307</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000034">
        <property type="protein sequence ID" value="ORX33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871854.1">
        <property type="nucleotide sequence ID" value="XM_022018141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5C6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5C6"/>
    <dbReference type="GeneID" id="33559950"/>
    <dbReference type="InParanoid" id="A0A1Y1U5C6"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="245" mass="27486" checksum="B99C9109448A26B3" modified="2017-08-30" version="1">MGRFHRALWPIDGPTCKDIKQTSVPDCFLAATLCVLADRAPHWLQSAVRKVDPEDADDGSTVDTAEFNIFKYREPEAIERSSTGANQMMIDQTSDHVWTRMNYADDIMGEETDGKATYESTDMIPTWWVPGFQNAAQKMFGDDFLQGGYTLEALAMLTNRITIDISDDIFKKASYTPVTLGTVDDPGKLVGNHAYAVLSAQMDDDDETVTLHNPWGKTDTYKLKDIFNDIAHVTHLKNWDILKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6V0</accession>
    <name>A0A1Y1U6V0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin N terminal region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_334323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000031">
        <property type="protein sequence ID" value="ORX33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867611.1">
        <property type="nucleotide sequence ID" value="XM_022012520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6V0"/>
    <dbReference type="FunCoup" id="A0A1Y1U6V0">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6V0"/>
    <dbReference type="GeneID" id="33554328"/>
    <dbReference type="InParanoid" id="A0A1Y1U6V0"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="803" mass="88231" checksum="1619E0A12138A011" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6V7</accession>
    <name>A0A1Y1U6V7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_654291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000030">
        <property type="protein sequence ID" value="ORX33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867621.1">
        <property type="nucleotide sequence ID" value="XM_022018784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6V7"/>
    <dbReference type="FunCoup" id="A0A1Y1U6V7">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6V7"/>
    <dbReference type="GeneID" id="33560593"/>
    <dbReference type="InParanoid" id="A0A1Y1U6V7"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="156"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="354"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="452" mass="51688" checksum="FAB38428A5E6E0D4" modified="2017-08-30" version="1">MMFLRSLQPIASCSRSASRILPPVAARGPRLTRFVTTRTTPYHINGQTYPLDDHSNVPPTILAKLDRNLHLNPSHPISILRSIIESHFSTFTPVTPSSPILTVTQNFDDLGFTPDHPGRALSDSYYLNKNHVLRTHTSAHEIETYQKGLNQWLLTADVYRRDEIDSSHYPVFHQMEGASVWPSSELYKLPQMNAELASKLAECPLIIEDTSSISPENPYQKSHDPEHAAQITQHLKHSLNSLIFRLFGPIATKDGEPLRIRWIDAYFPFTSPSFEVEVWWDGDWLELLGSGVMQQPLLNRAGVPDKSGWAFGLGLERLCMVLFSIPDIRLFWTEDPRFISQFTPGQITPFKPYSKYPPVTRDVSFWIPDASKKGVTQWHENDYCEIVRDVAGDLVETVQLIDEFTHPKTGRRSKTYRLTYRSMDRNLLNDEISGLQSEVERRTISEMGIEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6X5</accession>
    <name>A0A1Y1U6X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_198995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868080.1">
        <property type="nucleotide sequence ID" value="XM_022012161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6X5"/>
    <dbReference type="GeneID" id="33553969"/>
    <dbReference type="InParanoid" id="A0A1Y1U6X5"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48806" checksum="0D03231CFEF1366A" modified="2017-08-30" version="1">MSIGRLDAKVKLDYPSRVHYGPDDKVTGCVHLTYYPEAKTISDSNHELFAKLALDVTFHGRAKSKIWVNRGQQRSIHRGRVQLFTITKRIYHDVFKIQSGESLPIPFELSFPERAQLIGYQEEWRSNFRFLGLESNLILPPSMHIERSLFGNSASAFVEYRIGCSAQVERLKVVVTTPSRALEPIVNYDRPRRPMIHSEPWTLRGMVTVSNKELMKAAFHSDYYPTYTFDYTVDCPREIYNHCPITLIVKIMPKETTIRRSDLVEPLVTFGECSMEFQSVASIRASAGLLSEHEYERDDQAVTLRGRQEPMGPFNASEGNTKVITFDPVFVPSSFKFVNITLGYRIKVKYEFTVAGKVSTFGKEYQVSVRPPPPGTNQSSAQTEVAPSYRDAMASRNSSSSSLAGPSSKEILASTQVNPSLPRDPPPPTYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Z5</accession>
    <name>A0A1Y1U6Z5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_610448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868099.1">
        <property type="nucleotide sequence ID" value="XM_022014199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Z5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6Z5"/>
    <dbReference type="GeneID" id="33556007"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Z5"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="259"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="47934" checksum="696EECD34CE3B4EF" modified="2017-08-30" version="1">MAMMETGRVVGKPKKRSPPSEKRMKWMLATMAMMMILEGWNDGSLGPVIPALQDYYHVDYMHISMIFILTFCGCFIAGFGNIWLDDALGFGYTATFGSACQGMSYIVNVWGPPFPIFVAAFIFTGFGFALQDAQCNALCSRLPNASTKLSLLHACFGLGAFIAPFFATAFVQAYRQKVYLYFWMPFGVAAITVTLLVLVFQGRSVDDVVESESSEKAMDDEAAVPLVESGKDVLREEEEKKEVISGTDKLRRLFSDSAIMYILLFIIVYVGYEVAIGGWAVTFLIDARGASLDSGYVSAGYYGGIAAGRAILIPVTNALGHRRAIFVYLIAAILLEVCIMLAPSIFIDAVAFSLVGVVIGPIYPAAIVVITEIIPLNLQSGTIGLMGALGGAGSAMMPFIVGALSDFLGIWVLQPVCILLMIGDLILWILIARKEKIAPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U780</accession>
    <name>A0A1Y1U780_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867740.1">
        <property type="nucleotide sequence ID" value="XM_022017308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U780"/>
    <dbReference type="STRING" id="4999.A0A1Y1U780"/>
    <dbReference type="GeneID" id="33559117"/>
    <dbReference type="InParanoid" id="A0A1Y1U780"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="955" mass="103766" checksum="93416D7B338130E2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7H1</accession>
    <name>A0A1Y1U7H1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_637869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868267.1">
        <property type="nucleotide sequence ID" value="XM_022017059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7H1"/>
    <dbReference type="FunCoup" id="A0A1Y1U7H1">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7H1"/>
    <dbReference type="GeneID" id="33558868"/>
    <dbReference type="InParanoid" id="A0A1Y1U7H1"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="113"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="267"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="392"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="514"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="624" mass="69422" checksum="474DA3814C421FD2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7K2</accession>
    <name>A0A1Y1U7K2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase regulation protein NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_584247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868281.1">
        <property type="nucleotide sequence ID" value="XM_022013673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7K2"/>
    <dbReference type="FunCoup" id="A0A1Y1U7K2">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7K2"/>
    <dbReference type="GeneID" id="33555481"/>
    <dbReference type="InParanoid" id="A0A1Y1U7K2"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="574" mass="64415" checksum="5C17E0B0C67214D4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Y3</accession>
    <name>A0A1Y1U7Y3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_584730</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867964.1">
        <property type="nucleotide sequence ID" value="XM_022013703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Y3"/>
    <dbReference type="FunCoup" id="A0A1Y1U7Y3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7Y3"/>
    <dbReference type="GeneID" id="33555511"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Y3"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="490" mass="56433" checksum="CCDB5AAADE9A01AC" modified="2017-08-30" version="1">MSSTSDLRKRKSNPVLRSDDIRNGNSTALLKVNAVPTEHGQEMDKKLDEHQTYEFGGPVGVTAMMVGFPLLMYYLWICLWYYQGRFVHPTSVEDIGPFFRRMWMHCLDGAYPNAFAWKTYLGLTFGELFFAAVLPGVTQNGLPVPSLNYATLPYHCNALFSWYSTLLVAFGLHKTGIFRLPWIIENFGHLMTVAIITSFACSLAMDLLARGFHWGGKPLRLSHNLVYDHFMGISLNPRLGPVDLKMFAEVRVPWVLLFLISVSGAVKQYEELGRVTYNMAHMVFATGLYINACAKAEHMIPQTWDMFHEKFGWMLIFWNMAGVPFTYCYPTIFMVRASPSTYEFPLWGNIAMFVTLCTCYYIFDSSMAQKSTFKMQQQGDYKPRNAFPVVPWSEVKNPTYIQTKHGNKLLTCGWWQFARKINYTADWFQALTWGLTGGFNTPITLFYPIFFLAVLIHRCGRDFEKCALKYGDDWVEYCKVVKYKFIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U802</accession>
    <name>A0A1Y1U802_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_334253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000031">
        <property type="protein sequence ID" value="ORX33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867610.1">
        <property type="nucleotide sequence ID" value="XM_022012519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U802"/>
    <dbReference type="FunCoup" id="A0A1Y1U802">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U802"/>
    <dbReference type="GeneID" id="33554327"/>
    <dbReference type="InParanoid" id="A0A1Y1U802"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001135">
        <property type="entry name" value="ABC transporter F family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="182"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="522"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="739" mass="82565" checksum="64EF7BFA939EF9F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U898</accession>
    <name>A0A1Y1U898_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_637297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868539.1">
        <property type="nucleotide sequence ID" value="XM_022016987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U898"/>
    <dbReference type="GeneID" id="33558796"/>
    <dbReference type="InParanoid" id="A0A1Y1U898"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="151" mass="16770" checksum="5BC3F2502ADC98C2" modified="2017-08-30" version="1">MRLVIQKVKRSSVILDDEEIASIGRGLIVLIGIDKDDTEADIEKCVTKILKTRVWENSEGALWEKDVMDVECEVLCVSQFTLLASVNRGTKPNFRAAMPPSDAQNIFASMVNKLKQAYKADKIAQGKFGSTCEVMLVNDGPTTILYDTRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8P3</accession>
    <name>A0A1Y1U8P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_683340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868651.1">
        <property type="nucleotide sequence ID" value="XM_022019181.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U8P3">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8P3"/>
    <dbReference type="GeneID" id="33560990"/>
    <dbReference type="InParanoid" id="A0A1Y1U8P3"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1152"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="877"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1255"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1297"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="896"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="964"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1321"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1369" mass="151310" checksum="BBE9E394FDCFA54F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Z1</accession>
    <name>A0A1Y1U8Z1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase III subunit Rpc25-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_637824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868255.1">
        <property type="nucleotide sequence ID" value="XM_022017053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Z1"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Z1">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Z1"/>
    <dbReference type="GeneID" id="33558862"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Z1"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="233" mass="26388" checksum="CD3B934A3FAF1B28" modified="2017-08-30" version="1">MFVLIGVRDTVPVKPEAFEIPAAITIQDAINKKYANKLIPQKGLGLSCFDILTAEDGRVTWGNGLMYYKVSFRLLLFAPFIGEVLVGQVLSTTKSYIRVSMGFFNDIYITPNLLPPNSAYDPNEERFFWLSDPEPEDRVYTQHELLNTVVTSRLFIDPGEPIRFRVSDIEWQDVRPQPKARHDIANGHEEESEEDPFHKAGYKIFATIADVGLGVVSWWADAEEVGEEAMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U959</accession>
    <name>A0A1Y1U959_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Raptor N-terminal CASPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_583305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868831.1">
        <property type="nucleotide sequence ID" value="XM_022013615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U959"/>
    <dbReference type="STRING" id="4999.A0A1Y1U959"/>
    <dbReference type="GeneID" id="33555423"/>
    <dbReference type="InParanoid" id="A0A1Y1U959"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="4">
        <location>
            <begin position="84"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126432" checksum="57C6C8FF01777ADD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9P3</accession>
    <name>A0A1Y1U9P3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome subunit RPN7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_683192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868995.1">
        <property type="nucleotide sequence ID" value="XM_022019176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9P3"/>
    <dbReference type="FunCoup" id="A0A1Y1U9P3">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9P3"/>
    <dbReference type="GeneID" id="33560985"/>
    <dbReference type="InParanoid" id="A0A1Y1U9P3"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="183"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="381" mass="43062" checksum="BC52BDB4EC391CC9" modified="2017-08-30" version="1">MADEHVPLPYPNLKVAQWHYQVTSVPRLKDEASSSFWKAVEADEMAPYLTYVESSNSSLISSLSEKNKAELDRLDQKLKEAEENQGDSEISEFLRSRAMYLCRIGDKERAIPALEKALEKTAGLGARIDLVLAMIRMGLFYSDSDLVTANITRATDLIDSGGDWDRRNRLKVYRALYHLSIRDFKEAAELLTDTLSTFTATELMEYDDFVALTVLASGVGCDRKGIKTKILASSEVNGAMATITQLFTMTDSLYKSNYTQFFLALAEVEQHYLIPNVFLAPHARYYVREMRIKAYAQLLESYQSLTMERICRSFGVSETFMDRDLSRFIANGRLNCTIDKVSGVIQTNKLGTQNKTALYEQVIKQGDVLLSDVQKLHRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9W8</accession>
    <name>A0A1Y1U9W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_637465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868584.1">
        <property type="nucleotide sequence ID" value="XM_022017012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9W8"/>
    <dbReference type="FunCoup" id="A0A1Y1U9W8">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9W8"/>
    <dbReference type="GeneID" id="33558821"/>
    <dbReference type="InParanoid" id="A0A1Y1U9W8"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000595">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="359"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="581" mass="63320" checksum="1CA1CE981AF3A2DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB64</accession>
    <name>A0A1Y1UB64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_133669</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869026.1">
        <property type="nucleotide sequence ID" value="XM_022011998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB64"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB64"/>
    <dbReference type="GeneID" id="33553806"/>
    <dbReference type="InParanoid" id="A0A1Y1UB64"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="513"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="339"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="455"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="654"/>
            <end position="655"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="846" mass="92784" checksum="8AFAEA74394CF4A4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB92</accession>
    <name>A0A1Y1UB92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_582435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869500.1">
        <property type="nucleotide sequence ID" value="XM_022013556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB92"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB92"/>
    <dbReference type="GeneID" id="33555364"/>
    <dbReference type="InParanoid" id="A0A1Y1UB92"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF144">
        <property type="entry name" value="METALLOTHIONEIN EXPRESSION ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="112" mass="12881" checksum="E70B49622FF8D9DB" modified="2017-08-30" version="1">MTNQAVKRFKCLIEGCERHFPRKSAIHSHIQTHLEDKPYLCPTEDCNAAFVRQHDLRRHMRIHSGTKPFPCPCGKGFARGDALHRHRQRGICSGSIVPRRGSPDPGHRFEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBE4</accession>
    <name>A0A1Y1UBE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative multi protein-bridging factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_635246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869079.1">
        <property type="nucleotide sequence ID" value="XM_022016798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBE4"/>
    <dbReference type="FunCoup" id="A0A1Y1UBE4">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBE4"/>
    <dbReference type="GeneID" id="33558607"/>
    <dbReference type="InParanoid" id="A0A1Y1UBE4"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="152" mass="16042" checksum="D665CD93944EFC9E" modified="2017-08-30" version="1">MSDDWDKPTIIGQGRNRPTAVKGAALNIAQRSGTALETTAKDRSQTKGPADYQRKAKLDLDDAPKPPEKVDQSVAKALAQARAAKTKPDGKSMTQKDLATAVNAKPSDIADLEAGRAVPNQQLLGKIERVVGVKLRGAPDLIGTPLGGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBR9</accession>
    <name>A0A1Y1UBR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869142.1">
        <property type="nucleotide sequence ID" value="XM_022018527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBR9"/>
    <dbReference type="GeneID" id="33560336"/>
    <dbReference type="InParanoid" id="A0A1Y1UBR9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="647" mass="70411" checksum="2FE1950EC301D640" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC53</accession>
    <name>A0A1Y1UC53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_652131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869746.1">
        <property type="nucleotide sequence ID" value="XM_022018444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC53"/>
    <dbReference type="FunCoup" id="A0A1Y1UC53">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC53"/>
    <dbReference type="GeneID" id="33560253"/>
    <dbReference type="InParanoid" id="A0A1Y1UC53"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965589" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="5">
        <location>
            <begin position="27"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="7">
        <location>
            <begin position="263"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="6">
        <location>
            <begin position="497"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="639" mass="68072" checksum="3EB4B613AE8D914A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC77</accession>
    <name>A0A1Y1UC77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_630936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869805.1">
        <property type="nucleotide sequence ID" value="XM_022016391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC77"/>
    <dbReference type="FunCoup" id="A0A1Y1UC77">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC77"/>
    <dbReference type="GeneID" id="33558200"/>
    <dbReference type="InParanoid" id="A0A1Y1UC77"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="519" mass="58496" checksum="2ED1C9DFB7B377A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCK0</accession>
    <name>A0A1Y1UCK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy-related protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_134467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869037.1">
        <property type="nucleotide sequence ID" value="XM_022011999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCK0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCK0"/>
    <dbReference type="GeneID" id="33553807"/>
    <dbReference type="InParanoid" id="A0A1Y1UCK0"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="3">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="238" mass="26713" checksum="F341BA9B5CFC9993" modified="2017-08-30" version="1">MSSLEKPSGLGPPAWQNTIRLRLMERQAEAELQNEVLDQYRRLSKTARDLKDRNRALLRGGAGSGSGSGPSSGEGSPVVSRPSPILSHLDAQLSTLRAELSTVYRTQAASQNRQLALSDALRDRDEEVRGLREEVRELRDARDTAVRKEKDWDERWKMRTKDLETLNDEILSLNVELSGMAQNNAALKADNASLLQRWLDKMNLTAEEMNEDFEKETTKHVGSKESGVPRDFQQGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCN8</accession>
    <name>A0A1Y1UCN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_632233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869487.1">
        <property type="nucleotide sequence ID" value="XM_022016500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCN8"/>
    <dbReference type="FunCoup" id="A0A1Y1UCN8">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCN8"/>
    <dbReference type="GeneID" id="33558309"/>
    <dbReference type="InParanoid" id="A0A1Y1UCN8"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="434" mass="47543" checksum="00ED448D066781B1" modified="2017-08-30" version="1">MDYGMLSAYFQLGFQALFPLVVGSFKSLQTPASTKAKRRAARHAAPELSENDDEDDNDSDEDLSETLSWTDSLAVPILGSVALLSLWLLIKYVGKEWVSFCLGVYFSVFSVFALHSTSSTLVNFILRKLGSKPSVYHIRISTNLKQLAHTAVTLPTVLLIPLAIALPSLYLPLGRPFWISNILALSLATTTLSLLKLDSFLTAFSLLALLLVYDVFWVFATPVMVDVARGVDAPIKLLAPKSGSSLDFAMLGLGDIIVPGLVIALCLRFDMYRHTVSHPTHQITRHDAFGRAYWYVAMTSYILGMAGTMSIVHWSGKAQPALLYLSPACILGPLLFALARGEFKLFWGFSDAPGDESQKSKLDETIEAPSEAAMRAKQGILEDQAEKTDQMAENVSHPVQQEEEDDSWMDGTGVATGGGEEKSRKTKKKGAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCW0</accession>
    <name>A0A1Y1UCW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_633132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869121.1">
        <property type="nucleotide sequence ID" value="XM_022016598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCW0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCW0"/>
    <dbReference type="GeneID" id="33558407"/>
    <dbReference type="InParanoid" id="A0A1Y1UCW0"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="246" mass="27139" checksum="BBE8762B587CF9C9" modified="2017-08-30" version="1">MGLHPHSPSDYPSFLLYVLDETHLTITVLHAAIIIYTRDAHIAWIAVGALGSSLSAKGIKHFIRSPRPPPPPPTSNTDLKSHVRPKKTYGMPSTHSTALSFYFFYLVPELLLSSQMLASLPFTLGIRIPLPASIRPYIPSFSAVPKLRSAGTFGSVRPPRKEILDSLTTGQRWSSAIGITAYWLGGLWSRIELGYHTYSQVVVGAAFGWLLSTLWRGVWIANPALGPWLQGWIDTVWNLGRGLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCX9</accession>
    <name>A0A1Y1UCX9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_633237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869141.1">
        <property type="nucleotide sequence ID" value="XM_022016606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCX9"/>
    <dbReference type="GeneID" id="33558415"/>
    <dbReference type="InParanoid" id="A0A1Y1UCX9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="24277" checksum="161158FC2A2FBAD9" modified="2017-08-30" version="1">MLAAVTMPQTTEAEKRARKIEMDTSSKSFLSALDKLESLAVNLQSQESRKSIAATRNLFEAADQPEPWKALFEYSQHRSAMLEKEGEDERSSQALLCDALLARILELESAGPSYHLAMFWAQTGTAVLTALSLVGEGVSNIALCARDIGRAAQSTTPGFSGWSNSQGVEPGTTVQDNTTETVTNDGQVFEDDKPVSIANSKVEPNTTGITARSPYSSEKREALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD06</accession>
    <name>A0A1Y1UD06_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_629585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870067.1">
        <property type="nucleotide sequence ID" value="XM_022016230.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD06"/>
    <dbReference type="GeneID" id="33558039"/>
    <dbReference type="InParanoid" id="A0A1Y1UD06"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
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</entry>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
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                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1UDC5_9TREE</name>
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    </protein>
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        <name type="scientific">Kockovaella imperatae</name>
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                <person name="Spatafora J.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDD3</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD324DRAFT_682335</name>
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    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2591811at2759"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="386" mass="42817" checksum="3E01A8A4771ED54E" modified="2017-08-30" version="1">MAEGINKKSVPLTHPTHVQDIIAAPLEENDIELFMSNLGDYVNAASVPSIRHIQFLFYLSLFPPAAPLKPSPLFLLKRLLACHSPVTLSVASPVPSYGSQVPVYANWHVDTGIQMERQTMKLLKRCRAGVWDLFWVSVEEEDKVVSDTAWELIGWCVELWEKDQAESEDSFSALFVAQLGGPSPDLAKDNASSIVDITRCAFEESGASLSQMRRIELAARMFALLINATTVSPPRFHPPSLSLTFLPLFRSALGPEHISMFLSILQPRTPHYVLAHIYTIALEELAGCRISRARSRKLRGSTDDFDYSFGALAPPTVTFLLGDLLLLPPRPDQDNRMAVIKLALVGIMLGQYPGAEAWLVSPDTLERLKETNPDSIIITLLQHALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDJ1</accession>
    <name>A0A1Y1UDJ1_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_652135</name>
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    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
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                <person name="Gryganskyi A."/>
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                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">NRRL Y-17943</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="188"/>
            <end position="202"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX35586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="571" mass="63862" checksum="5C86116DD3BBEC1B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEM1</accession>
    <name>A0A1Y1UEM1_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="371"/>
            <end position="400"/>
        </location>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="51725" checksum="D234BB7EF47091A7" modified="2017-08-30" version="1">MTRGPAPIEKDSPPLSPHLAHYTLTHSMPEMPSTPAPTKARISHLESQISELVRRSHAIERKHKMEVGEYVEEVDRLKRELKASEEFKTKAGDMDRMKAEAEQLKEELNLHSLVQQQKALLAVVSEQMDLIDMEYQNLQLQSERVMRDYKMTLFEAREDDLNAELAEKDAQMADLEIALAEANTSIAHQQAAESKAAREETKALAARIVILEKELKVSKEKERTLRTELDSALTSEQSRDGSTEKEKSELKKSLRETKAMLAKKTEEFSDLQEELSSLQEASKEREKTLKAKIKDAVAERDRLVGVEVELESLKSANAKLRATTSDAAKKAPKAPKSKKPASDSEDEIVPAKKARKAAQADTSHLPALKEMTSNDTSKLQPSIPSVKVTGTDNGDVSLASTAEPEKKKKRKLFGAAPAFTWDPIMSSGDGVIPACLSPVKPNEKAAVGTIPRKGFGSMASARNLSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UER1</accession>
    <name>A0A1Y1UER1_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Kockovaella</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870580.1">
        <property type="nucleotide sequence ID" value="XM_022018379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UER1"/>
    <dbReference type="GeneID" id="33560188"/>
    <dbReference type="InParanoid" id="A0A1Y1UER1"/>
    <dbReference type="OrthoDB" id="2596526at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="627"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="707"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="880"/>
            <end position="909"/>
        </location>
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            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
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            <begin position="50"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="680"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="97427" checksum="0D6066D4C99A2A6F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UET1</accession>
    <name>A0A1Y1UET1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPP family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_581321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870145.1">
        <property type="nucleotide sequence ID" value="XM_022013491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UET1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UET1"/>
    <dbReference type="GeneID" id="33555299"/>
    <dbReference type="InParanoid" id="A0A1Y1UET1"/>
    <dbReference type="OrthoDB" id="2016548at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058581">
        <property type="entry name" value="TM_HPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33741:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="TM_HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HPP transmembrane region" evidence="3">
        <location>
            <begin position="48"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="28478" checksum="4FBE5A75F25B8EDA" modified="2017-08-30" version="1">MNPKPHRLAHWPPIVSRFLGYRSTPTGPWSPLPFPPFAWLPHLPYIMEKYMFGFIGSFVSLFLIQLAMTLPHSAFSSVYHSPIIIGSFGASAVLVFGAFEVPLAQPRNLVGGHFISALIGVCLTKLFALDPGYHAWVDEADRGVFHVVVIVNGCLSMALALLAMDLLGVIHPPAGATALLAAVSPSVVRLSWHYLPVIIVSSLIMLGVGLINNNVGRKRYPMYWVKPAPPPPKPNNPPEVKEGIHDNGDQERTKRDIAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF25</accession>
    <name>A0A1Y1UF25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_682269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870266.1">
        <property type="nucleotide sequence ID" value="XM_022019143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF25"/>
    <dbReference type="GeneID" id="33560952"/>
    <dbReference type="InParanoid" id="A0A1Y1UF25"/>
    <dbReference type="OrthoDB" id="2564806at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="665" mass="69629" checksum="D7DAC199077FE1B2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF50</accession>
    <name>A0A1Y1UF50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_580284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870742.1">
        <property type="nucleotide sequence ID" value="XM_022013431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF50"/>
    <dbReference type="FunCoup" id="A0A1Y1UF50">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF50"/>
    <dbReference type="GeneID" id="33555239"/>
    <dbReference type="InParanoid" id="A0A1Y1UF50"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="352" mass="40147" checksum="DD126F8AFBDE6553" modified="2017-08-30" version="1">MGCTQSTEDVAAKQRNDEIEEQLRRDRANLRNEIKMLLLGAGESGKSTVLKQMRLIYNKPYDDDERDSYREIVYSNTVQSMRVLLEGVQLMEVSINPQNQSRWDIIMAAPPQVEGEAFPPRLAEAVAVLWQDQGVREAFDRRNELQLNDSAPYYFDAINRIAAPDYTPTDQDILRARVKTTGITETHFKIGELTYKLFDVGGQRSERRKWLNIFDSVSALVFLIAISEYDQKLYEDETVNRMEEAMTLFESVANSRWFTKTSIILFLNKIDLFRAKLSHSPLANTFPEYRGGANYDAACAFLLDKFVGLNKNPAKSIYAHYTDATDTRALAFVISAINDVIIQVNLRDAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFG5</accession>
    <name>A0A1Y1UFG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_628035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870345.1">
        <property type="nucleotide sequence ID" value="XM_022016075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFG5"/>
    <dbReference type="FunCoup" id="A0A1Y1UFG5">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFG5"/>
    <dbReference type="GeneID" id="33557884"/>
    <dbReference type="InParanoid" id="A0A1Y1UFG5"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="469" mass="50510" checksum="001A685DAD806509" modified="2017-08-30" version="1">MSPIRVEERPPSSLLYRDLKGQLPDIVVEAKGSYLYLKNGARILDGCAGAGVASIGHGNERVINAVADQLRTLSYHHTSRMTSPVAEALGRKLVGHKPGGLSHAIFLSSGSEANESAIKLVRQYFVEIGKPQRQHIISRNNSYHGNSVGCVSLTGLPSRRRHFAPMLMPHVSQVSPCYPYRQQGADESDQAYAQRLADELEQEILRVGEDSVAAFFVETLGGTAAGNLVAVPGYFKAVREVCDKYQVLLVLDEIMCGMGRTGKLHAWEWEGVSPDIQTIGKGLNGGYQALSAVLINERVVDGLRQGSGAFANGQTFQCHPAAAAAGLEVLKIFEEEDVVNTALKRGAELRSLLIQELGSHPNVGDIRGRGLFQSLEFVANKETKETLPANIPISMLLDNAIFERGALIYSGFGKGTADGYRGDHILMAPPLNISSAEVKELVDAIKGGVEEVFSRPEVVAATRAAVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFI4</accession>
    <name>A0A1Y1UFI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_642356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870857.1">
        <property type="nucleotide sequence ID" value="XM_022017481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFI4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFI4"/>
    <dbReference type="GeneID" id="33559290"/>
    <dbReference type="InParanoid" id="A0A1Y1UFI4"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="74363" checksum="9BE229CE2249FB0B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFR2</accession>
    <name>A0A1Y1UFR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative hydrogen-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_591978</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870034.1">
        <property type="nucleotide sequence ID" value="XM_022013809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFR2"/>
    <dbReference type="FunCoup" id="A0A1Y1UFR2">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFR2"/>
    <dbReference type="GeneID" id="33555617"/>
    <dbReference type="InParanoid" id="A0A1Y1UFR2"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="205" mass="21290" checksum="F733AA3DC037D7DA" modified="2017-08-30" version="1">MGYLYPSLAISGTSTAIVVGLYLLFTGQGEAFNVGQFLAESSPYAWALVGTGLCIGLSVLGAGWGIFITGASILGAGVRAPRIRTKNLISIIFCEVVAIYGVIIAIIFSAKINGNVQNMYTTNNYFTGFAIFWGGLAVGLCNLFCGVSVGITGSTAAVADAADPQLFVKILIVEIFGSVLGLFGLIGKPASHGIDADRPFLQSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFU7</accession>
    <name>A0A1Y1UFU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870487.1">
        <property type="nucleotide sequence ID" value="XM_022016132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFU7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFU7"/>
    <dbReference type="GeneID" id="33557941"/>
    <dbReference type="InParanoid" id="A0A1Y1UFU7"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8490" checksum="1C1898C23991720A" modified="2017-08-30" version="1">MGQDPAPGLGQKALLAKKFARANSKPTISPTDQMQSPCTQKLSEAKQRHYGKGKPASLAQSFVAIRESSGASSNPGSKADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGM5</accession>
    <name>A0A1Y1UGM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S2, flavodoxin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871216.1">
        <property type="nucleotide sequence ID" value="XM_022015764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGM5"/>
    <dbReference type="FunCoup" id="A0A1Y1UGM5">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGM5"/>
    <dbReference type="GeneID" id="33557573"/>
    <dbReference type="InParanoid" id="A0A1Y1UGM5"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="325" mass="35480" checksum="0D25C28AD294C14D" modified="2017-08-30" version="1">MRPCTSTSSRFLARSCPVNAQATGRNFASSTCSSNAEAESSRAAMSRSVADTSASVTRADREEAFQRRLRQIQAFRRQKEATHIKIPFIPQDEASQPIDTSPTPLRAALSTLMASGAALGGSPKNLNKNYKNYIYGYRSGLAIIDLEKTLPLLRHASAVIRDVVKADGVILFVGTATGMERCMDKAKKRMGDNGFMTNKWIPGLLTNPQSLFGLQPLLKGSNAPDLVVFLNPADVSFGVRECTVRAIPTIAIIDTHLDPRVVTYPIPANGDSLRTVELICGTLSMAGAEGRRMRLREQEALSSRAQKRAAAQDEVREEEEHEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGN3</accession>
    <name>A0A1Y1UGN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871220.1">
        <property type="nucleotide sequence ID" value="XM_022015766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGN3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGN3"/>
    <dbReference type="GeneID" id="33557575"/>
    <dbReference type="InParanoid" id="A0A1Y1UGN3"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058:SF1">
        <property type="entry name" value="DUF427 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058">
        <property type="entry name" value="SLR0655 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="2">
        <location>
            <begin position="68"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="206" mass="23536" checksum="1E9C64C8DBBEC1CA" modified="2017-08-30" version="1">MRLNRLPRLVCTRFSCSPSPPSRTMSSNREVPMAPRKEDEDVWKYPRPPLLQRTPNLLRVVWTDLEGNQTVIAETDKAFRVLETSHPPTYYLPPSSLKLPVQALSRSTFCEWKGQASYYAIRPPGAKKPIENRIWYYKQPNPSFVPLKDHVSFYASTGVDEEEVGGRWDCFVDDEKVVPQAGDFYGGWLTSNIKGKTKGGPGTWVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHA0</accession>
    <name>A0A1Y1UHA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_627456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870923.1">
        <property type="nucleotide sequence ID" value="XM_022015999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHA0"/>
    <dbReference type="GeneID" id="33557808"/>
    <dbReference type="InParanoid" id="A0A1Y1UHA0"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="175" mass="18722" checksum="4C7C4F25E58CC737" modified="2017-08-30" version="1">MRTDDPSSRFHTSSPESKQSHEIPCRPMDLNGSKLSSESQGDGNVKLSHCNIKGSSRVFGNANLQHTTLSGNARVSDSADLSHCKVCNNATVLGDAFLRHCTVGQHAVVEGAAKLSHCKLGQQSKVRGKADVNHAIFGGFDHRGRRSESQRIELSRVTLSSRGPPSSMAAISSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHA3</accession>
    <name>A0A1Y1UHA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_449755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871469.1">
        <property type="nucleotide sequence ID" value="XM_022012814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHA3"/>
    <dbReference type="GeneID" id="33554622"/>
    <dbReference type="InParanoid" id="A0A1Y1UHA3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010988347" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9522" checksum="2222F4798D0A5DFC" modified="2017-08-30" version="1">MRRKHMSYHLFLFGGCGGVILTCTPCEKGEIGVRYTISTLIGYGQCDEGQIAFHGQTPPFFGAGHPLSVSNPRSVAHSAGINPSMLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHG0</accession>
    <name>A0A1Y1UHG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_579611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871467.1">
        <property type="nucleotide sequence ID" value="XM_022013394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHG0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHG0"/>
    <dbReference type="GeneID" id="33555202"/>
    <dbReference type="InParanoid" id="A0A1Y1UHG0"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="296" mass="32231" checksum="4F29F7F752B68790" modified="2017-08-30" version="1">MTKLEQVSSNRVSTGTLTKYAFESTSLGGLKTNVNVFVPFTNKPASPVPVLFYLAGLTCNEDTGAQKGGLFNKAGEEGLALVLPDTSPRGAGIEGEDDDWDFGTGAGFYLNATADKWKKHYNMYDLVVEEIPKVLKEADLGLDFDKVSIMGHSMGGHGALTLYLKNLDKYTSASAFAPACNPSRTPWGTKAFQNYLLTRTRSSPPSEWTPYDASHLLSSIDAPKGSLRMLVDTGSADDFLKKGQLEPDALKEAAKASGRGEDEVQIRLQDGYDHSYYFISTFSPEHIAFHAKHLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHK0</accession>
    <name>A0A1Y1UHK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_650109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871520.1">
        <property type="nucleotide sequence ID" value="XM_022018101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHK0"/>
    <dbReference type="FunCoup" id="A0A1Y1UHK0">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHK0"/>
    <dbReference type="GeneID" id="33559910"/>
    <dbReference type="InParanoid" id="A0A1Y1UHK0"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="36"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="29707" checksum="B18F5429CD3B028D" modified="2017-08-30" version="1">MSVHPTTLKTYGSRVSLHSNPTAKRLLEIMERKQSNLCVSIDVTNTAEVLEIVRGVGSKVCMVKTHADIISDFSSAFADELVRFSKELDFIIFEDRKFADIGNTVVHQYQSGPLAIASWAHLTNAHPIPGPGIITGLSSVGLPLGRALLLLGEMSSKGNLATGEYTKKTMQMAKEAGREFVVGFIAMSRVDPEEEEDWLMLTPGVGLVQGGDKMGQQYRTPRDVILDSGCDVIIVGRGIYGVKGGKDAMEAEAEKYRRAGWEAYEERLKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHX0</accession>
    <name>A0A1Y1UHX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PrpF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_642088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871112.1">
        <property type="nucleotide sequence ID" value="XM_022017464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHX0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHX0"/>
    <dbReference type="GeneID" id="33559273"/>
    <dbReference type="InParanoid" id="A0A1Y1UHX0"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="435" mass="45355" checksum="AF5FC7E82DC70BB8" modified="2017-08-30" version="1">MSSNSSTASSSSTHSPQSSPHTSPSSIALELPSPAHRRRCIRSVLMRAGTSRGLFFRTADLPEDQSLWGPILLAAMGSPDPYLRQLDGVGGGTSTTSKVAVVGPSKDPRADVDYLFVQVPVDGSRLDFSGNCGNIASGVGPFAVDEGFIKVPESGKSDVTVRIRNVNTDRIIHSTFEVQDGVPVEIGEMQLDGVGATGSPIRLDFVDPAGSMTGKLLPTGSPLDTVTLPSNTSSQPARTFTVSCVDAANPFVFVDARQLGLTGLESPAEIASSTTETLMDIRAVCAVHMGLASSHETARQVMGTPKIAIVAPPMDYSVPAVDGGKRIIRSTDVDIWIRPFSMGRPHPSIQMTGAVCVGSASAVPGTIVHEIISGSRASRMPRANGDEAVIVGHASGTMAINGESETIAGHVVVKSGSVYRTARRLMEGSVCCVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI70</accession>
    <name>A0A1Y1UI70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_650311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871750.1">
        <property type="nucleotide sequence ID" value="XM_022018126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI70"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI70"/>
    <dbReference type="GeneID" id="33559935"/>
    <dbReference type="InParanoid" id="A0A1Y1UI70"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="298"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39755" checksum="3F3BD9B06E1C5649" modified="2017-08-30" version="1">MEEGSGWVWDSRDLVYFHPSSNTYAVSTNGEWSYVHATEFKPGEPSSAMADHRTELEEGEVRDDVGWGALIEGTERGQIATPVDIEVLRLVIISSDILTLHKVIMIDGTSPEGIQIGRDKVPGPTRVRLKEMAVSKTHAVIFRQGPEWCIVDLGSTHGTFVVSGSGAAERLSPPKHASQPHPLKHLDKITIGSTTVVAHLHPDWPCDACQINGDNMFELFQDTGKRDQTTEIEISPRYAGPRGSHEMSLLRKSLLKDNGHSATKNSVYVDRSALRRQMERPSSRRSASPPRLSEPSKPASFAARMLGKQGWVEGKGLGAQNDGIAEPLSVKANKDKRGLGDDEEDWRIRGKKKRWRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIB8</accession>
    <name>A0A1Y1UIB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CWC16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_641893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871785.1">
        <property type="nucleotide sequence ID" value="XM_022017456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIB8"/>
    <dbReference type="FunCoup" id="A0A1Y1UIB8">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIB8"/>
    <dbReference type="GeneID" id="33559265"/>
    <dbReference type="InParanoid" id="A0A1Y1UIB8"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39508" checksum="10336E4BEB2F0C6A" modified="2017-08-30" version="1">MQGFNRYIPPDYDPKQSSTLNKHQGKKHALGKRAKDIDKGVLVVRFELPFNIWCGSCGSHIGAGVRYNAQKRKVGNYFSTPIFAFRCKCHLCSGWFEIRTDPKNAAYVVEEGATRKDEDWNPEENGGFAVHDTEAPSAAEPPADPFAHIEKTVDQQTWAKTKTSRLTELHQASDRLFGDPYRVSSALRRKFREEKKVTLEKQGRDDDLRERYGLHEEVDLGGENVDLAREKWEAGRERAGLPVEKELDNEAEGSGVGDISVRATAGTPRPRYSAKGKNGDGISFSESLRRSTAKKYDPFDSPIPGSNGSTANGVAGLTSSLKVKGRIKDPGPIGIKIVKQAQPSASEVVAGGLLSGYGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIE1</accession>
    <name>A0A1Y1UIE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome maturation factor UMP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_625472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871304.1">
        <property type="nucleotide sequence ID" value="XM_022015804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIE1"/>
    <dbReference type="FunCoup" id="A0A1Y1UIE1">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIE1"/>
    <dbReference type="GeneID" id="33557613"/>
    <dbReference type="InParanoid" id="A0A1Y1UIE1"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="157" mass="16967" checksum="A2710AB7BEE0D197" modified="2017-08-30" version="1">MSYRLVPPTASSSNDHHVVSTQATAHPELGLHDAMRHGPSSAAQSVAPDNISPLQARLEKWSSTQHDMQQTMHRNTFGLALPLRTAMEMRIVTQSPHHPSMIAATPSSLPLGGGPNLAAEILAGTDETLDVADFMVGNRLLNVPMDERAVMERSRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU8</accession>
    <name>A0A1Y1UIU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_626138</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871462.1">
        <property type="nucleotide sequence ID" value="XM_022015872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIU8"/>
    <dbReference type="GeneID" id="33557681"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU8"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="14">
        <location>
            <begin position="279"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="740" mass="82228" checksum="A165156B6EC9769D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJN8</accession>
    <name>A0A1Y1UJN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_577959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872193.1">
        <property type="nucleotide sequence ID" value="XM_022013288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJN8"/>
    <dbReference type="FunCoup" id="A0A1Y1UJN8">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJN8"/>
    <dbReference type="GeneID" id="33555096"/>
    <dbReference type="InParanoid" id="A0A1Y1UJN8"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="31728" checksum="0FD394172B4F0903" modified="2017-08-30" version="1">MTRLVSFHSPDPPAQAIQAFFVRYPNPFARHVLSVDVLDRWIDLETGRLHTKRLILKRGILPKWAARWLPVSSSSGGRGLDAWVMEDSVVDPPGWGEWWSPPKDKAGQLVKGKEREDWDVYRWLPRLKLVQGNLNHRKFMHVLEGGELRGQSDGHTSHITTVEIRSDFGGSWSKLIRDRIEAQGAGRFLKNTERARQGMILILDAMRNRQPLPADTMEFYPPPAPSFGDHWPSPTDQNRKDSATSPSEESQGSYWNRWRRKEEHDHDHDDQDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJT0</accession>
    <name>A0A1Y1UJT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_620105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872161.1">
        <property type="nucleotide sequence ID" value="XM_022015245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJT0"/>
    <dbReference type="GeneID" id="33557053"/>
    <dbReference type="InParanoid" id="A0A1Y1UJT0"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF91">
        <property type="entry name" value="GENERAL ALPHA-GLUCOSIDE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="772" mass="83720" checksum="CB2FFA1EF782A454" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJX1</accession>
    <name>A0A1Y1UJX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_398010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871753.1">
        <property type="nucleotide sequence ID" value="XM_022012678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJX1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJX1"/>
    <dbReference type="GeneID" id="33554486"/>
    <dbReference type="InParanoid" id="A0A1Y1UJX1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013073195" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="140" mass="15284" checksum="AF7AD592D6657296" modified="2017-08-30" version="1">MKFSILSVLSLSLLTSFASASAADQLQIGVKYKPDDCPIKTRKGDKLSMHYTGTLAADGSKFDSSLDRNVPFEFTLGTGQVIKGWDQGLTDMCISEKRKLTIPPDMAYGARGHPPVIPPQSTLVFEVELLGIKNRHADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK18</accession>
    <name>A0A1Y1UK18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_620480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872261.1">
        <property type="nucleotide sequence ID" value="XM_022015289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK18"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK18"/>
    <dbReference type="GeneID" id="33557097"/>
    <dbReference type="InParanoid" id="A0A1Y1UK18"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="289"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="615" mass="67492" checksum="4E5E70E1323E70F3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK54</accession>
    <name>A0A1Y1UK54_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871904.1">
        <property type="nucleotide sequence ID" value="XM_022015627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK54"/>
    <dbReference type="GeneID" id="33557436"/>
    <dbReference type="InParanoid" id="A0A1Y1UK54"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="365" mass="40993" checksum="11B4C54E48930DAF" modified="2017-08-30" version="1">MLVDEGLISLDTDMRKLYPALDKAAARIFKGLDQEQKPIFETNDKPVTLGQMLNQSSGFGMEFGDKVPEWKKITEKGKGFVNSCKVENLIHTPITFSPGTHYEYGNSAEWLALMFPTISQGREYEEFLQDRLCGPLGMKGTTFFPFGKAWDDRLRVLRYARDAGGRPGGAAAPGETVKEPKDWTWEKLDGQLDLLTLPRKREEIEYPAGGGGVYSRTCDYVLLLQHLMRHYLSLDSSSNVTPPAHPLLSDSSVKSLFYGTLSQEARPAMEKMLSWYLDTDISSGEADWTTGMSLYAPREGNTTRTWGRKRGSVGWGGAAGTMYWIDPTSQIAVVWTTQMLPGQPDYIRQGKKDIERLIYESLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKM1</accession>
    <name>A0A1Y1UKM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">BD324DRAFT_621542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKM1"/>
    <dbReference type="FunCoup" id="A0A1Y1UKM1">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKM1"/>
    <dbReference type="InParanoid" id="A0A1Y1UKM1"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="71"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="379" mass="42290" checksum="3CDDFF19CEF881DD" modified="2017-08-30" version="1">MSGLIKLSLAGRIMPPTPCSLCETARALVKRPKTGQQVCKECFFTVFETEVHNTIIQGDDGQGIFKRGERVAIGASGGKDSTVLAHVLSLLNQRYDYGLDLFLLSIDEGITGYRDDSLETVKQNQVEYGLPLKILSYDELYGWTMDRIVQQVGKKNNCTFCGVFRRQALDRGAAQLDIDHIVTGHNADDIAETVLMNIMRGDIARLGRCTAVTTRSEDTMRRSKPFKYAYEKEIVMYAYFKKLTYFSTECIYSPDAYRGHARVFLKDLEAIRPSAIIDIIHSGETFKLEQAVVKGMKPLQSCARCGYMSSNTICKACALLQGLEAGLDRSALKQSQDETSVLPDGQRMIPKYERLRRDVSKSASQIDGLEKPLKGMAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKN6</accession>
    <name>A0A1Y1UKN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872454.1">
        <property type="nucleotide sequence ID" value="XM_022018059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKN6"/>
    <dbReference type="GeneID" id="33559868"/>
    <dbReference type="InParanoid" id="A0A1Y1UKN6"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="755"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="849" mass="89741" checksum="8FFB75CDC23315D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKR6</accession>
    <name>A0A1Y1UKR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_373923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872562.1">
        <property type="nucleotide sequence ID" value="XM_022012618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKR6"/>
    <dbReference type="GeneID" id="33554426"/>
    <dbReference type="InParanoid" id="A0A1Y1UKR6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="22400" checksum="14AA1B12162A00C5" modified="2017-08-30" version="1">MQRHYASGHDPERSDDDDDGPTCCQHRKLGIEGFRKPFGASRVTIESHSRSTFFFFFFFFFFFFFSSIQFWIEYQVQINYPTVQSQGGHRNQTTGLPIWARPTNNIPRSEGRFKTVPVTHHRVNLLSRREPASLLNCTVLLALEYIAASQSPLPRTQRQQTKQPTSEFFVYSAFIWVDYRETSEHHLLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL77</accession>
    <name>A0A1Y1UL77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872158.1">
        <property type="nucleotide sequence ID" value="XM_022018021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL77"/>
    <dbReference type="GeneID" id="33559830"/>
    <dbReference type="InParanoid" id="A0A1Y1UL77"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="404" mass="45310" checksum="32759CD831E0086B" modified="2017-08-30" version="1">MLCRPPRSPINREQRPPAYLVRPSGTCETVSGLFALWHEELEIVIDSMVRESLPDYSVKAKTALEKYASGTMTQEEYEKTVTDMAESQYELLETWKSKDLSNYAEEDEVRADGRSLGLVPGSQAETEPEETKGLLEEDTGPLETSYAGTDCTFKDAFDKWSEWTKQTAKLQNKVILWWLERQAQDMQSVRSNLIEGKSSTNDTQKILEIKALGFHPQIQTWQRDPSNNNPDERRIVAKLNEECSIMSRSQTDALCGSNAQTIFHHLRALGFEDSSEMLTDHDTSIPAESFQGESRRVTQSTSFSAFINQSPQLLPRIGIEFDSKMSYTPDVYIGALASAHALIFPGSSTAPDPQFSSTFVFTEVGDPSRKNRVATFGAKLLTKSMEKWCSEGGENANADRKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULA0</accession>
    <name>A0A1Y1ULA0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872691.1">
        <property type="nucleotide sequence ID" value="XM_022017909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULA0"/>
    <dbReference type="GeneID" id="33559718"/>
    <dbReference type="InParanoid" id="A0A1Y1ULA0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="43828" checksum="6535CD01FAC87917" modified="2017-08-30" version="1">MGEDESPRKKKKARLHVRGELSSGTSKSSKPEPKPVRGEIEAQLVKRSVPNRPRFPPEILERLILSLDPETDKRALSRCLRVSKLMFDLAAPLLYRQIVAHPCLDPSRNPLCPLPKGVKRSDPTVPILDEKYQRCSLLRMVQRITVPYNHVHVFGGILRELAENGGLRVVVQDFDRQGVEATALATPQKPQQGSGWALSRSKPHQAASIIALTRREEQPQIIIKFDSRTLDRLHNALFLDPLLGVSRNRVTLIYWSPQPGQGAGPCAFGLSADSYSWRLLTVATSSQLDLTVVNAVSIVKAIDSRSTSDPVTTYEKMVKMTEKSFELFKKYVKPQERSADSSETPPGKVRFLTMDQYIEQEDWRLAFTEREMEPWLEAKKAVVKVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULN4</accession>
    <name>A0A1Y1ULN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 9">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_620824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 9"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872346.1">
        <property type="nucleotide sequence ID" value="XM_022019296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULN4"/>
    <dbReference type="FunCoup" id="A0A1Y1ULN4">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULN4"/>
    <dbReference type="GeneID" id="33557134"/>
    <dbReference type="InParanoid" id="A0A1Y1ULN4"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="10">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="217"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="522" mass="59068" checksum="205D389AC3A35EA8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULP1</accession>
    <name>A0A1Y1ULP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_679490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872836.1">
        <property type="nucleotide sequence ID" value="XM_022019042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULP1"/>
    <dbReference type="GeneID" id="33560851"/>
    <dbReference type="InParanoid" id="A0A1Y1ULP1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="252" mass="27473" checksum="4075801BE220C8FD" modified="2017-08-30" version="1">MPYVPPKGHGIIPRKKVTGRIPRTRHFPKPKGVHDDQSTPRGEHHNDAQDPSSSSSLADRLAATRLSPSWNSMDDANMDQEDKESYPRTSMDSNTNAPIRPTRTTASSASIPSLADNLTATTSSTSLHSPETQSVHLTSEEQPTGKRMDEAGNHATSASISSVSSPVNTTPSEITMVTSTTSLSEMVDENAQSLQRYKAGLYTYTRTLYLQAQQTIQRKAAIESLPQFGLNKTAVDRKSAKRAMAKRLSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULW3</accession>
    <name>A0A1Y1ULW3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactonase, 7-bladed beta-propeller-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872852.1">
        <property type="nucleotide sequence ID" value="XM_022017933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULW3"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULW3"/>
    <dbReference type="GeneID" id="33559742"/>
    <dbReference type="InParanoid" id="A0A1Y1ULW3"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="364" mass="39704" checksum="B9FFD7C9F477793B" modified="2017-08-30" version="1">MSTEHLLLLGTNIDKIYGVIFDEKAKTLRKTAENELAPKSSWIIQHPNIADLIYFNAAGESKLFAGTFDRHGKVTILDEAQQSEESKGPCHFALAPDNSALIVANYHSGNICMLPLNDNGRFMNAKTEPSLNFTPPHKPVDHPRQTEAHAHQIVVHDGRVLVPDLGSNKVWRIRPGHGDDQSRWVLEGAVEGFDVGDGPRHVVVHPNGRILYVLNEISSELTAHTLPSDPSKPSELLSRHTLLPPSDQGNGPKMKASALIYLPPLAPTGNAMLIGSNRDSPRGKDALAVFSVDPEGRVERAPTPWIEDVAQSLRGVAADKSGRFVCAAGEESGGLVVYERVGNVELRQVARLDEVEKVIAPLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMD9</accession>
    <name>A0A1Y1UMD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_621719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872558.1">
        <property type="nucleotide sequence ID" value="XM_022015402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMD9"/>
    <dbReference type="FunCoup" id="A0A1Y1UMD9">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMD9"/>
    <dbReference type="GeneID" id="33557211"/>
    <dbReference type="InParanoid" id="A0A1Y1UMD9"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="304"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="619" mass="67009" checksum="2E87E5C87BB97EAE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMG0</accession>
    <name>A0A1Y1UMG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate carboxylase</fullName>
            <ecNumber evidence="4 13">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_618947</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="4 13"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873104.1">
        <property type="nucleotide sequence ID" value="XM_022015101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMG0"/>
    <dbReference type="FunCoup" id="A0A1Y1UMG0">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMG0"/>
    <dbReference type="GeneID" id="33556909"/>
    <dbReference type="InParanoid" id="A0A1Y1UMG0"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.90">
        <property type="entry name" value="Conserved carboxylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="20">
        <location>
            <begin position="43"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="19">
        <location>
            <begin position="163"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="21">
        <location>
            <begin position="579"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="18">
        <location>
            <begin position="1114"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="660"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="16">
        <location>
            <position position="757"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="17">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="17">
        <location>
            <position position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX39241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1193" mass="130658" checksum="C57451DDFA4AB701" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMG8</accession>
    <name>A0A1Y1UMG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_680383</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872606.1">
        <property type="nucleotide sequence ID" value="XM_022019078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMG8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMG8"/>
    <dbReference type="GeneID" id="33560887"/>
    <dbReference type="InParanoid" id="A0A1Y1UMG8"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX38684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="123" mass="13661" checksum="A856BCB52E937AC7" modified="2017-08-30" version="1">MSLARRSIAVYENTPEEGFFEREKAKLIDEISSSFEELMTHTNVLNRKHEEVYGVGKEFKTVAELWGTFNALIRKQQVSWSGIPTALDKSLIRRQSDLAATADVGVPGTGSANFGASVNQPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMK6</accession>
    <name>A0A1Y1UMK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873085.1">
        <property type="nucleotide sequence ID" value="XM_022017968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMK6"/>
    <dbReference type="GeneID" id="33559777"/>
    <dbReference type="InParanoid" id="A0A1Y1UMK6"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="85" mass="9562" checksum="06436C7C540F1A1D" modified="2017-08-30" version="1">MSTAKQRHYAALASRLRALKTNLAESEVQMDALARHLDKMRHLGANHAAQFMAVSRILDVDLEKEKERVQAAYDAEAQEPEQESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMZ3</accession>
    <name>A0A1Y1UMZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_619424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873235.1">
        <property type="nucleotide sequence ID" value="XM_022015172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMZ3"/>
    <dbReference type="FunCoup" id="A0A1Y1UMZ3">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMZ3"/>
    <dbReference type="GeneID" id="33556980"/>
    <dbReference type="InParanoid" id="A0A1Y1UMZ3"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000350">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="63"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="609"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="920" mass="102191" checksum="340066053EB7B54E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN15</accession>
    <name>A0A1Y1UN15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_333136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873314.1">
        <property type="nucleotide sequence ID" value="XM_022012514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN15"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN15"/>
    <dbReference type="GeneID" id="33554322"/>
    <dbReference type="InParanoid" id="A0A1Y1UN15"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="362" mass="38688" checksum="79AC9C4C953088BA" modified="2017-08-30" version="1">MARPPPASGSGTSTPAGTVSSGPSPAQTPSAASGSAARPPASNQSRGDGLMNIPAMLNLDKAGKLDKDQISKVRTMILQQARPIVAMALHRNQPNPLLALPPHLNPSMSAEGQSALINKADFEILMAKGVEDSKKIGEIMPMSEIKKLLVFTQEQRHKMLLQDPVLKLRFTRSLTHYAQFNKANASNASSNPGNTPSNTNTAPSSTATPGSIPSVNASTSANSVPTPVAPVVPMVSGPPPLPPAPPIKMETEDERRKRKFTEMLQDEGGGIHAEMGIFDVLGDVLDSFIDSEARRAIRLAKHRKSPRVELKDVAFAIDDSYGISVPGFNAQVRDRIHTAPEADKKRRTVVPLKSRASKKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN85</accession>
    <name>A0A1Y1UN85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_618082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872840.1">
        <property type="nucleotide sequence ID" value="XM_022014986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN85"/>
    <dbReference type="FunCoup" id="A0A1Y1UN85">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="GeneID" id="33556794"/>
    <dbReference type="InParanoid" id="A0A1Y1UN85"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="555" mass="61498" checksum="69D4D1C401963611" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN94</accession>
    <name>A0A1Y1UN94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_587761</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872817.1">
        <property type="nucleotide sequence ID" value="XM_022013757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN94"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN94"/>
    <dbReference type="GeneID" id="33555565"/>
    <dbReference type="InParanoid" id="A0A1Y1UN94"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX38954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="301" mass="34905" checksum="98181E2DEDFF3D48" modified="2017-08-30" version="1">MHAPEVTDFVKLKAAQVEAIGDEIDHVNQIKYDEASKFDAEKDKDNFRRYEDACDRVKGFYKEQHTKQTLNYNLAIREKYAKNVNARMTVWEAMEMLNTLIDESDPDTSVGQIEHLLQTAEAIRRDGKPEWMQVVGLVHDLGKLLCFFGADGQWDVVGDTFVVGCEFSDKIIYGKDSFVDNPDIHDEKLMTECGIYERGCGLDNVLLSYGHDEYLYDVMRRQSKLPKEGLSMIRYHSFYPWHKENAYQHLMCEDDKAQLAAVRAFNPYDLYSKSDEPPKVSELKPYYQGLIDKWIPGEIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNB3</accession>
    <name>A0A1Y1UNB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_614126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873335.1">
        <property type="nucleotide sequence ID" value="XM_022014562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNB3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNB3"/>
    <dbReference type="GeneID" id="33556370"/>
    <dbReference type="InParanoid" id="A0A1Y1UNB3"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012463241" evidence="9">
        <location>
            <begin position="18"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="32"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="323" mass="35516" checksum="56D9553126B0D9EC" modified="2017-08-30" version="1">MLHHLLTLLTCLSTTIALPAKHLPVRQSTDSFRDIAYYAYFQDANHQPYNILPIIENPSHITHLNLFSVDLRTSGPNLTIGGVAPTDSSFLGDLWGEVKQVQQAGVKVLASIGAYQAECWILLQDDFNTWYPILLDFLQRYELDGVDLDIEPNAQGQTPNGIAAPLQLIQALRNDMAADFIISMAPVAADLTANPPEYSGFDYKQLDNAAVGPDGQHQIDFFNGQFYNGWGDCSDASTYDSIILNGYSPDRVIFGVLADSEDGNGFCSISTLTTTIKTIRTTYPTMGGADGYELVRAGQDDDLQNWQWFQGIYNASTTALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNJ1</accession>
    <name>A0A1Y1UNJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VPS4-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_614230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873364.1">
        <property type="nucleotide sequence ID" value="XM_022014575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNJ1"/>
    <dbReference type="FunCoup" id="A0A1Y1UNJ1">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNJ1"/>
    <dbReference type="GeneID" id="33556383"/>
    <dbReference type="InParanoid" id="A0A1Y1UNJ1"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="189" mass="20623" checksum="155FD38A86E05591" modified="2017-08-30" version="1">MASSSTSTPLQNIYYERKVATARPCYICKRPTETVLATLKTEDFLYTCDGHLSDPGFASPIAPPPSNSGPSPEDIRKVIADYHAREAKKASPTEKDAKESPQGSKNDTEGKDKSKSVNPGAEKSPAHSVDLSNMSNLPVSTASPPSTHRKYALHRQIFDMRRAEIKRKEQGVKAKEVSKGLPQVPRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNP3</accession>
    <name>A0A1Y1UNP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_618581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872987.1">
        <property type="nucleotide sequence ID" value="XM_022015051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNP3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNP3"/>
    <dbReference type="GeneID" id="33556859"/>
    <dbReference type="InParanoid" id="A0A1Y1UNP3"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="507" mass="56107" checksum="F9667145813C7AFD" modified="2017-08-30" version="1">MPVQPAYKTRADEVDDLVETVKNLIIPFIRSAEPSSSTSGSSKQYAAGDGVNGDQGQHPMTLVDYHAPKELQSILDLDLPSKGQGKDGLVNMTEKVLRYSVNTWDQGFMDKLYASTNAVGVAAELLTAALNTNVHVYQVSPVLTLIEKHVAKTLARMYGFTDPHSGGMSQPGGSAGNSSSIVIARNTLYPHTKTRGIGSDKYVLFTSQHGHYSLEKAAQMFGFGSDNVRSVPVDKTGRMDVSALRKMVVKSKEDGEVPFYVNATAGTTVLGSFDPFDEIAEVCKEHHLWMHVDGSWGGSVIFNKGIAEERLRGVEKADSIVMSPHKMLGVPVTCSFLLAKDMRKVWKAMTLPAGYLFHTSDSEEIFDLADLTPQCGRRGDALKFFLSWVYYGEEGLSEKIERAFELATRMQEQLSRSENVVMLSTMPPPCLQVCFYYAPERQLGDPTATSRRTEIMTERLMRRGFMVDYAPGENGKFFRIVINISTTEETVTRLVEMIEEVGRENTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNQ0</accession>
    <name>A0A1Y1UNQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_226098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873453.1">
        <property type="nucleotide sequence ID" value="XM_022012226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNQ0"/>
    <dbReference type="GeneID" id="33554034"/>
    <dbReference type="InParanoid" id="A0A1Y1UNQ0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="172" mass="18967" checksum="21C9D8301A46F16F" modified="2017-08-30" version="1">MNDTLIRTRTIARIKSERSGQGQTLARRHEDEERVWMDTQRAARLPHRHGHRDSYAQNGFASSPTPRVGEVMSPGMAFPARMGGGNSTPSRRPIPYHAFTAASGDSTLSGSTYSFPSSRGLSLKDEPAWLGIPSGASRETPVKEEKHRQWDTGPQTFAEMGFIDVCVVEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNT2</accession>
    <name>A0A1Y1UNT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_312092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872989.1">
        <property type="nucleotide sequence ID" value="XM_022012460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNT2"/>
    <dbReference type="GeneID" id="33554268"/>
    <dbReference type="InParanoid" id="A0A1Y1UNT2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="107" mass="12788" checksum="20F02DD546B51C8B" modified="2017-08-30" version="1">MASSSSPPKVIVKWKTEDEEELLRLIKTRTEWICLFAEGQQQLSQKWIYHRDIAIALWPHDQARERRFLWILQAKLRGLVVVKDGKWEPTDLWDHRVSNPIRNKISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNY0</accession>
    <name>A0A1Y1UNY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873110.1">
        <property type="nucleotide sequence ID" value="XM_022015107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNY0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNY0"/>
    <dbReference type="GeneID" id="33556915"/>
    <dbReference type="InParanoid" id="A0A1Y1UNY0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="231" mass="25785" checksum="4754AEFACA7BAFED" modified="2017-08-30" version="1">MIIPPSYAKAKWIVDHLMAYARAYGLIGGIFRIGQICGDSQHGIWNQREAIPLLIQAASVLGVVPYAYVDGKDQVSWMPVDHFAEGLVAAVVHHEDTGGNIPVWNFSNPHPTPWRRIVRATQRALPGGARAVPYDQWLDILKAHRKDSRVLAPKLLPYYSSGLFPAQPFEHVAVAATLAKDRLEGRGSWEFCEIDEALIIKMIIRWMEEGFIASAGPRLAHLHTSHRDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP19</accession>
    <name>A0A1Y1UP19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_320513</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873117.1">
        <property type="nucleotide sequence ID" value="XM_022012476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP19"/>
    <dbReference type="FunCoup" id="A0A1Y1UP19">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP19"/>
    <dbReference type="GeneID" id="33554284"/>
    <dbReference type="InParanoid" id="A0A1Y1UP19"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000104">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX39254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="307" mass="35935" checksum="26C37DCAB5A7052F" modified="2017-08-30" version="1">MTTSSNQFTTDEYVLAYHGPLLYEARILLAENWTESNTLLGTTGPHYFIHYKGWKQTWDEWVPEQRLLKLNEEGFAKRRQLLEQQTRKTRPITAASPAASSIKGKEKVPKKVEQGKKRTRESGIDTEADYLKRPEVKIVIPDILKLQLVDDWENVTKNNQLVILPRKPNVRDLLEEYRNYVLATKRSLDRSSRATSLLSEIIAGVTLYFDKALGNNLLYRFERAQYVEQKRLNPDKGMSEIYGAEHLLRLFVNFGPFIAYTNIDTESLNILREYINDIMKWMIKEQKRLFVKDYETTTTQYQSLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPC7</accession>
    <name>A0A1Y1UPC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873668.1">
        <property type="nucleotide sequence ID" value="XM_022017852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPC7"/>
    <dbReference type="GeneID" id="33559661"/>
    <dbReference type="InParanoid" id="A0A1Y1UPC7"/>
    <dbReference type="OrthoDB" id="2574168at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="274" mass="29673" checksum="F5389EFDE993EF18" modified="2017-08-30" version="1">MPSSRAYTPLADEVNPPFGNAVTTVTRNGTVVYGKRPTSESSGSSTPSRQYSAETTPQLASRVSMTQDHEQDLGIPRSAKGKERAWDPEMGQDEIKDDTYPPGNENAEEERRVADTLARFAARDAARRRAARLSKQLPPSPQSTSSGFLSRPFSVVERQSLRGLMENITGKHPSLPTTQPKPYNDPYSNQPYRDAGLDPFPRDSISSAGSSPGVDTAYGYAGPAWRGGAPVQVDERAHGGGEKWWHALCAWGDDLDGGHAEGADDQAGRTNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPD0</accession>
    <name>A0A1Y1UPD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_615270</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873644.1">
        <property type="nucleotide sequence ID" value="XM_022014704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPD0"/>
    <dbReference type="FunCoup" id="A0A1Y1UPD0">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPD0"/>
    <dbReference type="GeneID" id="33556512"/>
    <dbReference type="InParanoid" id="A0A1Y1UPD0"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140064">
        <property type="term" value="F:peptide crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="22" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="21">
        <location>
            <begin position="257"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX39859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="540" mass="60429" checksum="BF0537F926DF4C56" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPI8</accession>
    <name>A0A1Y1UPI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_615532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873704.1">
        <property type="nucleotide sequence ID" value="XM_022014733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPI8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPI8"/>
    <dbReference type="GeneID" id="33556541"/>
    <dbReference type="InParanoid" id="A0A1Y1UPI8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="38765" checksum="17827E5E3D7E3423" modified="2017-08-30" version="1">MDASYPPLETPGVSVSKSSPNSSSSPPVLVFSPAYTMPQANWYGYPSSTPGSYGYSHPMTPYTHMENLTPYTTYATTPAPVGGHALPLTATPTTERAYNTASLHAAAPSVLFGQPHSLYGSPASSISSALPLDKETTPPLLLPRRASESTTMDYYLPTPGLLPVGPPLPAATQIKKRSRTAQACEKCRIRKAKCSGGQPCTRCINKKLPCVFSGTTRSRGAARWREAAAREAAEQAAKLRTRRHSLDDPFATPNNAPVIRDVRRHSEGSIEPRLQNNSALGLDLNPIDELARPASACQTWAPYTVPYLETVSAYPWTPDHRFSDGSYSYPTPLSAGNVVPLTYADWSGQPSDWHGQCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ05</accession>
    <name>A0A1Y1UQ05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_616262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873888.1">
        <property type="nucleotide sequence ID" value="XM_022014816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ05"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ05"/>
    <dbReference type="GeneID" id="33556624"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ05"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="115"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="521" mass="56020" checksum="5DF43947823AE89C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ30</accession>
    <name>A0A1Y1UQ30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosyl-DNA phosphodiesterase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_258111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873894.1">
        <property type="nucleotide sequence ID" value="XM_022012301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ30"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ30"/>
    <dbReference type="GeneID" id="33554109"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ30"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="84396" checksum="888A3BF33BDD1364" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ71</accession>
    <name>A0A1Y1UQ71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_616411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873907.1">
        <property type="nucleotide sequence ID" value="XM_022014824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ71"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ71"/>
    <dbReference type="GeneID" id="33556632"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ71"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="135" mass="15448" checksum="E6153E151908DAAB" modified="2017-08-30" version="1">MNEPLENIEIQPDEDNVQLWRVIFHGPKHTPYAGGKFVLAVEFTLEYPFKPPMAKFRTKMYHPNVDSEGSLCLGILKSDQWKPSTKMSHVLVSIYDLLVTPNPDDPLVTSIADQYRTDRKGFEKKAAEYTSKFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQN7</accession>
    <name>A0A1Y1UQN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_271424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874057.1">
        <property type="nucleotide sequence ID" value="XM_022012341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQN7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQN7"/>
    <dbReference type="GeneID" id="33554149"/>
    <dbReference type="InParanoid" id="A0A1Y1UQN7"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="553"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="814" mass="89359" checksum="8CAA3A317D1B1603" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQX2</accession>
    <name>A0A1Y1UQX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_247327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873762.1">
        <property type="nucleotide sequence ID" value="XM_022012275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQX2"/>
    <dbReference type="GeneID" id="33554083"/>
    <dbReference type="InParanoid" id="A0A1Y1UQX2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="425" mass="48330" checksum="1CD2E8FBF9C2AE16" modified="2017-08-30" version="1">MYWGERYFPTEGKELTGQYTIIMSDISDPTSSGDASTLEGRVTNWQDQQSVTEEPITLQDTINSLKRWRVVAEEHSLPATAEARIFVRTQILRCIDNAIEGIIRSHRSFLTDWTRISRMLSQGDRQMVKRILDKEQAVELDERSKTFIEDLLPERRDRLDLRKSLNAFWENQTMLNTWVTDDFYTSQKQFADGMRKLENADFAFGRREASDDYDDSLKQASAIGDTSDAKSQKARLVRDRTRQLVKLYRQHSQGSFDESMSYLNYTLLDLSKHNVDTQMGWKLVQLVDHTALVGDPDSEQDTDLGWSIGDWGIQSLSNIGVEFRELYTTTVNAPRTEEATTAARHELAKGILDSVNRHVQNPDSDTPTGLPNPGDYETLVLRLEGVITKAKATFPDGSIMWSAPNFVDQIGLAGVEGAEDWVPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQZ9</accession>
    <name>A0A1Y1UQZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_610862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874150.1">
        <property type="nucleotide sequence ID" value="XM_022014225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQZ9"/>
    <dbReference type="GeneID" id="33556033"/>
    <dbReference type="InParanoid" id="A0A1Y1UQZ9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="670" mass="74272" checksum="E7E38FE89473C71C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR05</accession>
    <name>A0A1Y1UR05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874160.1">
        <property type="nucleotide sequence ID" value="XM_022018790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR05"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR05"/>
    <dbReference type="GeneID" id="33560599"/>
    <dbReference type="InParanoid" id="A0A1Y1UR05"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="117" mass="12894" checksum="BA3912B5A3350A08" modified="2017-08-30" version="1">MADNNTGAIDPKTGTSGHAQTGERFEVAPENAHLRLDKKDERSHANALADAEKVAAVERAVEEKKKELQEHPTAIAESHGNKPSRGAVIDEQLIQEEKEELAKKEEAKKQSEEAHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR65</accession>
    <name>A0A1Y1UR65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_615557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873711.1">
        <property type="nucleotide sequence ID" value="XM_022014738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR65"/>
    <dbReference type="GeneID" id="33556546"/>
    <dbReference type="InParanoid" id="A0A1Y1UR65"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="11"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="512" mass="55811" checksum="4F92ECB5409A7CB9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR66</accession>
    <name>A0A1Y1UR66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_614423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873420.1">
        <property type="nucleotide sequence ID" value="XM_022014595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR66"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR66"/>
    <dbReference type="GeneID" id="33556403"/>
    <dbReference type="InParanoid" id="A0A1Y1UR66"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="412" mass="44608" checksum="ABD75F0A3BB71314" modified="2017-08-30" version="1">MDIRPLPYIDIQHDALSVFDDVEQGVVGSEDIWVSGYKAGSSSVHGRARVVPREGGGTEIRARDGVEIKRLSKTHFEVSIPALHLDRIPVKFPRAVIHPPYTKASKLSPPLQVNSIALSPNGSHLLVGGPDGYCGVIPVGPGANAQDMIQFKGHVGDVLDVHWFPSGEVCLTTGSDLSIRIWGSKDGINPRTLTGHSRAVTSLYIVGVGKQILSGSKDGTVRLWEVGASTQLKRWNLDHIRPVEAVLVIEDDHGKAVLGAQEEERLVLVLTQVGMEIWNWSTPSSGSPRQSLEWQLGSNLVCGAYCPSLGILVTGHTNGVIAVRRLETLDKPTLFRRNESPVYSLAFKDTALYAGTAAGLPCRLEVSLKEGDQISLEVKEEFAGWEAVGVESWTIGQDSMWCAGGEGGIRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URI8</accession>
    <name>A0A1Y1URI8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_611766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874360.1">
        <property type="nucleotide sequence ID" value="XM_022014305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URI8"/>
    <dbReference type="STRING" id="4999.A0A1Y1URI8"/>
    <dbReference type="GeneID" id="33556113"/>
    <dbReference type="InParanoid" id="A0A1Y1URI8"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="108" mass="11642" checksum="A4208967C949A6D9" modified="2017-08-30" version="1">MVCKKCEKKTSTLAAPDPFQPSSSTRKIGENKLLTARARASPYAKPGGAGAGISKGKINTYGNKCIDCKQSVQQNYATRCQKCAYKKGLCAICGNIVLDTSRYKQTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URK7</accession>
    <name>A0A1Y1URK7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_611478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874278.1">
        <property type="nucleotide sequence ID" value="XM_022014270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URK7"/>
    <dbReference type="STRING" id="4999.A0A1Y1URK7"/>
    <dbReference type="GeneID" id="33556078"/>
    <dbReference type="InParanoid" id="A0A1Y1URK7"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="232"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="58013" checksum="7AD3BD84356419EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USD7</accession>
    <name>A0A1Y1USD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_612618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874619.1">
        <property type="nucleotide sequence ID" value="XM_022014412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USD7"/>
    <dbReference type="FunCoup" id="A0A1Y1USD7">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USD7"/>
    <dbReference type="GeneID" id="33556220"/>
    <dbReference type="InParanoid" id="A0A1Y1USD7"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="71"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="588" mass="64702" checksum="87A00A6E6F607168" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI6</accession>
    <name>A0A1Y1USI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_612737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874652.1">
        <property type="nucleotide sequence ID" value="XM_022014434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI6"/>
    <dbReference type="STRING" id="4999.A0A1Y1USI6"/>
    <dbReference type="GeneID" id="33556242"/>
    <dbReference type="InParanoid" id="A0A1Y1USI6"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62381" checksum="B7F2682626740A7F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USU1</accession>
    <name>A0A1Y1USU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_575120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874273.1">
        <property type="nucleotide sequence ID" value="XM_022013106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USU1"/>
    <dbReference type="FunCoup" id="A0A1Y1USU1">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USU1"/>
    <dbReference type="GeneID" id="33554914"/>
    <dbReference type="InParanoid" id="A0A1Y1USU1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="156"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="683" mass="74952" checksum="22B9504109B8E977" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USU3</accession>
    <name>A0A1Y1USU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_678474</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874760.1">
        <property type="nucleotide sequence ID" value="XM_022018995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USU3"/>
    <dbReference type="FunCoup" id="A0A1Y1USU3">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USU3"/>
    <dbReference type="GeneID" id="33560804"/>
    <dbReference type="InParanoid" id="A0A1Y1USU3"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="358"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="574"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="805"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX41081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="860" mass="95482" checksum="0E6868AFFDD3598F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT17</accession>
    <name>A0A1Y1UT17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-keto sterol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_37901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874771.1">
        <property type="nucleotide sequence ID" value="XM_022012629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT17"/>
    <dbReference type="FunCoup" id="A0A1Y1UT17">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT17"/>
    <dbReference type="GeneID" id="33554437"/>
    <dbReference type="InParanoid" id="A0A1Y1UT17"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX41092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44220" checksum="539D26A8BEFF7DFD" modified="2017-08-30" version="1">MPAAVIQKTALPPSRRQVLIDQAPELVSEVSDRPPATLTLIVTCRSMQNAIETKEAILETHMRELKMREKNGIPERNGWLAGLRIECETADLSSPGGSDGVLALCERLKKSYPHITSLFLNAAIATASSISFPGFLKQIFTEGFVETVTDPHFVPETPGVMTPDGRLGLVFSVNVLSVYIMARELEPLLRRSPKELPVPPRIILSSSYTAARSLLRPDPLDDYQLLTYSYENGEFPYKASKYMADLLAVQLDKEFSENQGEDTQELRMLIAEPGAMVSKIYTTAFTNWAIIKFTFTFFYALAFRLASLLGSPKHVLTAGNGALAMIFAALVDSQYIEPASKVPATKFESRLNRWKHHRIEYSEVDCWESTLDLGASLMKACETIRQEYRRRESLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT29</accession>
    <name>A0A1Y1UT29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_612110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874466.1">
        <property type="nucleotide sequence ID" value="XM_022014354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT29"/>
    <dbReference type="FunCoup" id="A0A1Y1UT29">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT29"/>
    <dbReference type="GeneID" id="33556162"/>
    <dbReference type="InParanoid" id="A0A1Y1UT29"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="84"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="289" mass="31166" checksum="5437F10B84FDC8C4" modified="2017-08-30" version="1">MANQGGYAVVDADEDDGQGGRAPGLEFKTFLGTESAQERMPSASTSSGRTPAEVPYSPFNLVYYQGYFDVETTTILKRVGMSMIPREGFIQEVCDGHIDLYGPFWTLTTLILTLYTTSTLTASISQYLSNPDLKPESNIPLLTTATSLLYIYGLGVPALLWAATKWLGVGDWGLAEALGIYGYAMGVYVPISLLCLIPVGILRWVLVGLGAVSSGYFMVRNIYPVLANADNKMLRLLIVAVAVLHGVMALAMKVLFFSYSVAGYNVGPDPIATNPILTAPTDTSDGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU14</accession>
    <name>A0A1Y1UU14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_575254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874796.1">
        <property type="nucleotide sequence ID" value="XM_022013117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU14"/>
    <dbReference type="STRING" id="4999.A0A1Y1UU14"/>
    <dbReference type="GeneID" id="33554925"/>
    <dbReference type="InParanoid" id="A0A1Y1UU14"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="100"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX41117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="454" mass="49778" checksum="33EF7C9F5B68472F" modified="2017-08-30" version="1">MASGVDVDGVLRGKIMSKSKFLSAVKSDGFGFCSVIFGWDIHDAPYHKELLVSNKANGYRDLIAKIDLSTYRRLPWERNIPFFLCSFVDPETSSPLDVDPRSLLQGVIGQAEELGYKAMAGAEFEYFQFRETPDSIKEKGFAGLNSLTPGMHGYSMLRPTLNSDYFHDLYDEAEKFGVEIEGHHTETGPGVFESALGYTEAYRMADNACLFKLLAKSVGMKYGIIPTFMAKPWGDLPGCSGHIHVSLQDKSGRNIFSLSDADQKAGGRGNAAHKDLKFLSKEAEWFLAGLLEGLADVIPMLCPTINSYKRLLGGEAFWAPDTASYGYESRVASIRIIGPPGSSASAARFEVRVPGADMNPYFAFAAIFGLGLRGIKRRIELPYGPVGSPGVTRGTLPHLPTSLSAATATFKRKDSIAREVFGDLFVDHFAGTREHELALHEKAVTSWEGEREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5G8</accession>
    <name>A0A1Y1U5G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_585277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867626.1">
        <property type="nucleotide sequence ID" value="XM_022013733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5G8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5G8"/>
    <dbReference type="GeneID" id="33555541"/>
    <dbReference type="InParanoid" id="A0A1Y1U5G8"/>
    <dbReference type="OrthoDB" id="2596424at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="176" mass="19447" checksum="E99EF87DFEA8EFCD" modified="2017-08-30" version="1">MVATKIDKLHRFFIQRRKPDSILVSTVVDVSVIGFLWILVLGGVAAESSVADVFDRCDRFTTCDLGKAVLGLGWLFFFMLLGLFCWMLIYTFMHYGSSWSVWRTPFALLVERGAPVASGRDVENKPGVPASTDHQQQAHHTAQPASTTYPPANDPVMGQAPLQMSQTQPTSTQAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5I2</accession>
    <name>A0A1Y1U5I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_684362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000028">
        <property type="protein sequence ID" value="ORX33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867645.1">
        <property type="nucleotide sequence ID" value="XM_022019216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5I2"/>
    <dbReference type="GeneID" id="33561025"/>
    <dbReference type="InParanoid" id="A0A1Y1U5I2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="343" mass="37828" checksum="AA5513D3F0B19717" modified="2017-08-30" version="1">MSASRDEDIVAEAASRILGKAMAVLLHHDQLVRHIHQSISDLVQPDLQLISPEHHPAILHALAFVPQHSYEYRVRAGMELAKLRIDPVTVQNTITSTKTHLQEASDEKKRSASFRSSIDTDFDFEADRVNPVHLDDLTDCQSATVVLQSPKHWRTTMQSVAPPTTGPCQTLHTSSSSSPSMSSIASSSTLVESVPTDPKTLNVPRVGKESSLRALVSATRTGLEKALLRQVMDSTREFIRDANLGPVSQGVLGAVDDAILIAPRYIASVRAVHIEISIHRDSKKRGGTKFHTNPLSGKPFNTLMLKVISWEESWSPEEVKVWIRSVCGLFEEAEKVVDRLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5S9</accession>
    <name>A0A1Y1U5S9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867726.1">
        <property type="nucleotide sequence ID" value="XM_022017298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5S9"/>
    <dbReference type="GeneID" id="33559107"/>
    <dbReference type="InParanoid" id="A0A1Y1U5S9"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="253" mass="27487" checksum="9C55ED50BF2266F6" modified="2017-08-30" version="1">MSHFTILPATDADVQELIHVLQMTLGKTAMYAAMMPYDTDGSIQRMMHEGRIRGALRDPAVRLFKMVVSRRVDTEVTGPDEGEGECAGENESRDTLCGCVALKLDEGRVVKSSSDGSVRTEAGDAIRSITSLPGGNEDALRAILEGVARLYDGMSGRHYGIEMLGVLPAYQNQGLATRLMEHCLRITDSESPSLPTWLTALPGANSVYTRHGFVGVDEDVVDLNAYDPTGRHLGSFAHRSMRRPPKQPAGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5X0</accession>
    <name>A0A1Y1U5X0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_280259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867768.1">
        <property type="nucleotide sequence ID" value="XM_022012365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5X0"/>
    <dbReference type="GeneID" id="33554173"/>
    <dbReference type="InParanoid" id="A0A1Y1U5X0"/>
    <dbReference type="OrthoDB" id="10655572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011009567" evidence="1">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="209" mass="22688" checksum="77D18C67CAAC136B" modified="2017-08-30" version="1">MRFSTFVATIVILIQTSFVAHTLAMPMATSSTEAFTLRQATAEQIITRQIIKFQRAKLNRMKEEDLASGLAMSKTKRLAPQPKVSNGATKTYPTCNVAGVNGYARYVGWDLYNDDLAGNPHYTKTRTEADSIALCNDNSNCAGAVIIEGGPSYLKGYKVSSGNFLPQPEGITTTMYLDLIGQCSDWAPYVPAAADAICCNSYGTTSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U600</accession>
    <name>A0A1Y1U600_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_654170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867795.1">
        <property type="nucleotide sequence ID" value="XM_022018761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U600"/>
    <dbReference type="GeneID" id="33560570"/>
    <dbReference type="InParanoid" id="A0A1Y1U600"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="174" mass="19486" checksum="F135843992692A42" modified="2017-08-30" version="1">MPDTTQDTANWTNPSCDCPAHRIYGQSDVPRFTEPLALSSRFDYSNGKSKRYCFPTCARMAFHTALHTWAARESTPFTIPQCSFAHPKVQELYECSPEAIEKAVPGYWQDALLLESVETNTNEGFINGAKGSILPLDKTVSVEESLRRWKDFETDQGTLSSVGCNETNKAMLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6F4</accession>
    <name>A0A1Y1U6F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_654053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867917.1">
        <property type="nucleotide sequence ID" value="XM_022018743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6F4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6F4"/>
    <dbReference type="GeneID" id="33560552"/>
    <dbReference type="InParanoid" id="A0A1Y1U6F4"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="567"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="758" mass="83254" checksum="21C83FEDDA69ED6E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6N0</accession>
    <name>A0A1Y1U6N0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_639181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868003.1">
        <property type="nucleotide sequence ID" value="XM_022017199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6N0"/>
    <dbReference type="FunCoup" id="A0A1Y1U6N0">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6N0"/>
    <dbReference type="GeneID" id="33559008"/>
    <dbReference type="InParanoid" id="A0A1Y1U6N0"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="169" mass="18281" checksum="09895F416163FD3E" modified="2017-08-30" version="1">MASSSASYVTFETSVGSFTVELYNNHAPKTCNNFSKLAERGYYNGVLFHRIIPGFMIQGGDPTGTGRGGTSIYGDKFADEIHPDLRFVGAGILAMANSGPNTNGSQFFITCAPTPFLDGKHTIFGRISSGMKTVQRLEAVRTDNNDRPVEDIKIHKARLGDATQNAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6R1</accession>
    <name>A0A1Y1U6R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868008.1">
        <property type="nucleotide sequence ID" value="XM_022017202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6R1"/>
    <dbReference type="GeneID" id="33559011"/>
    <dbReference type="InParanoid" id="A0A1Y1U6R1"/>
    <dbReference type="OrthoDB" id="2572629at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="228" mass="24926" checksum="F95CB95FCAA9FA2A" modified="2017-08-30" version="1">MPKRGGGGVDGSEEVTLTGPPSSTVTKDRHIHPNIKGSTGGFLGLITGIAVVLLLSLFAGFWIYNRRRRRRQHLVGKSRASVFGLPLPGTLSSIEGHDDTWDPYADPLPSPHEGGNRPRYARQRSEEWEIPPETLYAPTPSRIRGGSRREGDPLGEWEEMPNLPGETTAPLRSRSPRLSPLPFGSETPPRQPESKGKGTQRAEVQVNPFNSELDPERLSPTSSHSGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6X3</accession>
    <name>A0A1Y1U6X3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_640417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000031">
        <property type="protein sequence ID" value="ORX33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867612.1">
        <property type="nucleotide sequence ID" value="XM_022017347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6X3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6X3"/>
    <dbReference type="GeneID" id="33559156"/>
    <dbReference type="InParanoid" id="A0A1Y1U6X3"/>
    <dbReference type="OrthoDB" id="3243926at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="79294" checksum="C4E6DCD49C05CD5F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Q1</accession>
    <name>A0A1Y1U7Q1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BD324DRAFT_638236</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868348.1">
        <property type="nucleotide sequence ID" value="XM_022017091.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U7Q1">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7Q1"/>
    <dbReference type="GeneID" id="33558900"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Q1"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="2"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1553"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1146"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1152"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1157"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ORX34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2129" mass="233991" checksum="A76CAB3C50EC0001" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7R0</accession>
    <name>A0A1Y1U7R0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_193803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868331.1">
        <property type="nucleotide sequence ID" value="XM_022012141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7R0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7R0"/>
    <dbReference type="GeneID" id="33553949"/>
    <dbReference type="InParanoid" id="A0A1Y1U7R0"/>
    <dbReference type="OrthoDB" id="2594372at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="59453" checksum="74571EB04D52D58A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Y0</accession>
    <name>A0A1Y1U7Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calponin homology domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_594464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868390.1">
        <property type="nucleotide sequence ID" value="XM_022013833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Y0"/>
    <dbReference type="FunCoup" id="A0A1Y1U7Y0">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7Y0"/>
    <dbReference type="GeneID" id="33555641"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Y0"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="224"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="585"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="727" mass="81549" checksum="3E992476C10AB692" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U839</accession>
    <name>A0A1Y1U839_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CCR4-Not complex component, Not1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_171156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868477.1">
        <property type="nucleotide sequence ID" value="XM_022012085.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U839">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U839"/>
    <dbReference type="GeneID" id="33553893"/>
    <dbReference type="InParanoid" id="A0A1Y1U839"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="11">
        <location>
            <begin position="597"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="790"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="972"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="1276"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="12">
        <location>
            <begin position="1535"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1880"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2251"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2302" mass="255931" checksum="5F5BDC2921AC580F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U932</accession>
    <name>A0A1Y1U932_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_158365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868804.1">
        <property type="nucleotide sequence ID" value="XM_022012051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U932"/>
    <dbReference type="FunCoup" id="A0A1Y1U932">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U932"/>
    <dbReference type="GeneID" id="33553859"/>
    <dbReference type="InParanoid" id="A0A1Y1U932"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011008218" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="752"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="903" mass="99910" checksum="45280C0F171AC425" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U950</accession>
    <name>A0A1Y1U950_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_207114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867935.1">
        <property type="nucleotide sequence ID" value="XM_022012181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U950"/>
    <dbReference type="STRING" id="4999.A0A1Y1U950"/>
    <dbReference type="GeneID" id="33553989"/>
    <dbReference type="InParanoid" id="A0A1Y1U950"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="92"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="384" mass="42832" checksum="3D0396C48F36DCBE" modified="2017-08-30" version="1">MLIAPRFGPLCIRCTVTCTGGNVKVGQTGMQLPSTGDSLLDRPPPEVQRCAFPLSGPNFPTCTDHLMSTTEQPVQVEATRANERHEIVRLEVQTVQSIARGGWSQVTLVDAKWGSGPNVVVQRLVRKRARQPVAFKHRELEVHQDLKHPNIVKVEGWWYEMAADHEAEHGENVRYLNLLLSPYCPQTLNDVKGELSERLLLLFAQQLFGALEYLHAPERSVAHRDLKAENILIRITAEAEGQGHLQMYLCDFGCAKRILPTEQNGVEVGEPKTRAPEMLRQSGFGTYTTAVDIYAAGLLLFYALLGRDLVPARPNQQEQLLEYERVFGHAKTASEIISLIESESARDARPTPSQSVLQLLADVLTPDVNARPEAQELVRRLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U974</accession>
    <name>A0A1Y1U974_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868844.1">
        <property type="nucleotide sequence ID" value="XM_022018646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U974"/>
    <dbReference type="STRING" id="4999.A0A1Y1U974"/>
    <dbReference type="GeneID" id="33560455"/>
    <dbReference type="InParanoid" id="A0A1Y1U974"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="588"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="991" mass="110127" checksum="407246CFD19B2BBD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9F9</accession>
    <name>A0A1Y1U9F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_636851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868425.1">
        <property type="nucleotide sequence ID" value="XM_022016939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9F9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9F9"/>
    <dbReference type="GeneID" id="33558748"/>
    <dbReference type="InParanoid" id="A0A1Y1U9F9"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="450" mass="49107" checksum="E266E642E7D3C095" modified="2017-08-30" version="1">MKSGLARTLKRTESRCSCFRSPALARSARSYSVVSPSTSGRAESPLAKVLRDSIKATGPISVSRYMQWCLSHPVYGYYTQGDVFGQKGDFITSPEISQIFGELMAIWFVTRYIAAGHPKRCRIIELGPGRGTLMADILRTFDQLKSIASSLKSVHLVENSEKMRAVQSSNLDRFCEERDIAIHWVDRIDDVPPGDEFTFVVAHEFFDAMPINAFEKAPEGFRELMVDIDPENGSDSTSCSHSGLRLTRSREANSSALLIPATSPRFAALPIGARVEIAQDSWKIARKIGEMLQRSEPGSTSSSAGGAGLIVDYGADKLFPDSFRAIRKHEIIDVFDSPGESDLTANVDFAYLREAIEGTGTSALGPISQGQFLLSLGLQPRLQKLLASNTSPERKQDLIKGAQRLVDPVFMGSQYQIMGLLSGAGEGAEVYPFPSLVPTAAEPGETRPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Q0</accession>
    <name>A0A1Y1U9Q0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, 31kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_132466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869003.1">
        <property type="nucleotide sequence ID" value="XM_022011992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Q0"/>
    <dbReference type="FunCoup" id="A0A1Y1U9Q0">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9Q0"/>
    <dbReference type="GeneID" id="33553800"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Q0"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="211" mass="23545" checksum="8AC8AA7D380FFD95" modified="2017-08-30" version="1">MTSDTRPVPRDGRLISLILASKGIEDADERVIHQMLDFAHREQNGCYTADVLQSAQSLADHAGRAGPSRIEKEDVELAIQFRKRYEFFEPPPRDYLASLAHDLNSQPLPILPETFDVLRLPPPHQRLGEVDFNIVPNEELTLESEDEGDDDSSDSEDQEEDAVKTEDGVNGERASANPEADPDDGDDDMEEVGVSDQAPAQSRQVEEDYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9X5</accession>
    <name>A0A1Y1U9X5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_637534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868595.1">
        <property type="nucleotide sequence ID" value="XM_022017019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9X5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9X5"/>
    <dbReference type="GeneID" id="33558828"/>
    <dbReference type="InParanoid" id="A0A1Y1U9X5"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="32"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="547" mass="60240" checksum="1D2AA83D221695A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Y5</accession>
    <name>A0A1Y1U9Y5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_643324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869064.1">
        <property type="nucleotide sequence ID" value="XM_022017536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Y5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Y5"/>
    <dbReference type="GeneID" id="33559345"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Y5"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="277" mass="30098" checksum="F67A24080B8F0471" modified="2017-08-30" version="1">MSEQTEIKSCCVTGHLHQGQPLGSMETVHGVHSYVSKPKEASGDKVDKVILITDIFGIYNNTKLVADEWAGQGYEVYVPDFLGDSKVDEELLNTIAPNLRVQKEATVLPKAADTAKTGAAIGPFLITNREAVTKPKIEGFVQAVRAEPNTRHIAAIGFCWGGRYSLLLAQEDSPARVDCAIANHPSFLTNDDVKEIKSVPVAIFKGTQDAMMSDDALDEVEGILSKNLPSDKLVVQKFPDAVHGFTIRGDMEDGQEKQQKEDAQNAAIKFVKKAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAB9</accession>
    <name>A0A1Y1UAB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_110123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869199.1">
        <property type="nucleotide sequence ID" value="XM_022011930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAB9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAB9"/>
    <dbReference type="GeneID" id="33553738"/>
    <dbReference type="InParanoid" id="A0A1Y1UAB9"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41895" checksum="A0BCF680477E7853" modified="2017-08-30" version="1">MFRRPSKLFRPSRVDTFGGLKHLALSTDQNLSASFIRSLMSSKQGLIAVTLTILPPLLINTTLGFLLFTSHSFFSLSLAKLPFFHHPHDPTSSSSNYHPSHLDLSETDGTDRINLHTLMTGPSVIPYHPTLLSAIAGAGAGLLQGAAFTPIENVVKLLRDSASSITSILLRVLQLPLPKPATTVNTPASPLQALKQFLSSESWVKSPSWWTGWRWAMARDAISYSVFFAAFDVTRRVALRVRGFMTGTYEQSWSNFILFSPRQPTPNDEDSSGHAPTSARVAQAVTIVTGGVMASVAAEVVSRPIRASQKILSGPEALSSRYPLLHTYKTQGIKPFIRSETSLARIASESPLRRAVKRLGWRMAAVGPWGFGFLVWAWVGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAP1</accession>
    <name>A0A1Y1UAP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_633919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869324.1">
        <property type="nucleotide sequence ID" value="XM_022016677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAP1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAP1"/>
    <dbReference type="GeneID" id="33558486"/>
    <dbReference type="InParanoid" id="A0A1Y1UAP1"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33150" checksum="AD8F1E0BDD1E31F4" modified="2017-08-30" version="1">MSTSAQALAKSVKSGETLRVENLFEVKGRVALVTGGGTGLGLITANALADNGVRVYITGRRPEPLKAAARSKGENGGEIIPIVGDASDREGIRKVRDEISKKEKFLDILINNHGVSLPHADINACEQTPEGLSEEMFENEDFPVWEQMYRINTASYHFTTFAFLPLLAAAKSVGCRSEPGNIINISSMSGITVTSQRGQFNYNASKAATLSLTKMQATEFARRNFGIRVNCVAPGYFPSGMTVIEPENNTGSDAHFQEFRTKWAIPFGRPGNAVDYAQCIISLATNQYITGSETVIDGGWLLESAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAP2</accession>
    <name>A0A1Y1UAP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_119085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869337.1">
        <property type="nucleotide sequence ID" value="XM_022011951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAP2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAP2"/>
    <dbReference type="GeneID" id="33553759"/>
    <dbReference type="InParanoid" id="A0A1Y1UAP2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="285" mass="31786" checksum="30E87E407743D94C" modified="2017-08-30" version="1">MSVEQVNTNPIFAPADRPNKSACVLCPSKTFKNDHMATLHLKSGSHLRSLKRWHAALENYQKPGRGPRPEDPRVIVALNFRKIETQRVLDKARDKANTQAKVAARRARKVIKKAEREAYKAEHPKPSKQPKVLSESEQAALDARRAKKKLETAARKAVKQERKANRERERQQAFAAGNLNANSVPVASGGSGSSKYGAGASTSRSWRDGAAGGLAKKRVSPRMIRKRARDAKLLAMGIDPAAKTGDEEMSRKLQKRKKKQEKHEKQSAKRKMMAAQRFNNKGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAW5</accession>
    <name>A0A1Y1UAW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_634081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869375.1">
        <property type="nucleotide sequence ID" value="XM_022016701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAW5"/>
    <dbReference type="GeneID" id="33558510"/>
    <dbReference type="InParanoid" id="A0A1Y1UAW5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012485826" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="115" mass="12792" checksum="151C9054A893E161" modified="2017-08-30" version="1">MHTTVLLSLPWLVEGGLSADVLYDQERGVREGTDNNDNTERECVPLDSLHVGRSRVILVTQSALVLCRNEETESCVHSSMRTAGTLTNLIGNLLRPDIIWSVDEPVDHLVGYYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB59</accession>
    <name>A0A1Y1UB59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_632132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022016492.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="308383at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
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        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27203" checksum="C4B3A4BFADF786BF" modified="2017-08-30" version="1">MSEGSEESDTVEGCSCTGVSSLCTVTDGDNCECVESFGNFYTLGPSGHPILNLDAVPYRLPLVECGAHCSCSVKCFNRTTQRGVNLPVEIRQTKAGLGAFLSASADAVPIEAGTFIALYAGEYLSTSEARSRWQLESKDNYTLSLRLANAIIHIDPRYKGNVGRFFNHSCDPNCVILIVYWGGGWPRAAIFSKSIIQPSEELTFDYGNASGDQDAQDRVEGCVAEDDRPTLTKCLCGSVRCRGYMPFDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB96</accession>
    <name>A0A1Y1UB96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_634936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022016774.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UB96"/>
    <dbReference type="GeneID" id="33558583"/>
    <dbReference type="InParanoid" id="A0A1Y1UB96"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="131"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="297"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="515"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1153" mass="122462" checksum="3544BF3B2EF92ED0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBL7</accession>
    <name>A0A1Y1UBL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_154298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868748.1">
        <property type="nucleotide sequence ID" value="XM_022012035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBL7"/>
    <dbReference type="GeneID" id="33553843"/>
    <dbReference type="InParanoid" id="A0A1Y1UBL7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="229" mass="24844" checksum="1901FA0D9AB8EF17" modified="2017-08-30" version="1">MCKQVAQNSSLEAALFQFCDSVQSWSSLNMISQEEDRPAFRRLDSFDPLSLSGNMNEPSIEITEEVFPEGNNGSSIARPEPARMPSHLFVSPLPALERAEASTLIGVASIPLTSLQLSKETPICPSTSPMTGVSLSTAPSEHSQYTLDERQEGASSLHISSLGEPATHPRDFLHGRSLLFKCTFVSVTCSAQLIAQGQFGMVMIPLKEIGDYLRVESAGELSWMTASYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBQ2</accession>
    <name>A0A1Y1UBQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_633166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869132.1">
        <property type="nucleotide sequence ID" value="XM_022016604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBQ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UBQ2">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBQ2"/>
    <dbReference type="GeneID" id="33558413"/>
    <dbReference type="InParanoid" id="A0A1Y1UBQ2"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="422"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="546" mass="60404" checksum="C325F130C7FA1370" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCA5</accession>
    <name>A0A1Y1UCA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_652226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869842.1">
        <property type="nucleotide sequence ID" value="XM_022018462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCA5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCA5"/>
    <dbReference type="GeneID" id="33560271"/>
    <dbReference type="InParanoid" id="A0A1Y1UCA5"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="618" mass="67425" checksum="C551DAA7B6A84C2B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC1</accession>
    <name>A0A1Y1UCC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_631213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869855.1">
        <property type="nucleotide sequence ID" value="XM_022016413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCC1"/>
    <dbReference type="GeneID" id="33558222"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC1"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="485" mass="55106" checksum="CCB18DE9213B3C20" modified="2017-08-30" version="1">MMSAVGHATLFKFTTHKRLHVIKTDTSFSVTSKTGSWGSKSIHSLFATPGSWYSPRLYRMIFDIFRFNHSSMDVLDDPVKYANISLGAYLDFHHYGQGFRDDYLIPLASTYWSLPPSRVLQDCPIWVLVRCFHHFGLLRMWGRPEWYAFAGGSRTYVDAIGKQMHSEDVHLNTAIHSVSKNDHGVVLKDQHGMEREFDHVIMATHAQVTLAILRAGGSLDMTDENALVDSCDWSDFEITMHWDDRLMPEKETVRGAWNTTVSDASIGEEVDPTRQNMEVTFDMNSLHNFPREIYGNLYGTVNPSIQIDESKIFQRLRFSTPIFTPRLLKAQNRLNRNDMIRDSRISIVGAWRRLGSHEDAWITGLEQARKLGADLPFTIDEAMRTVDKSVLSGVTAYALESVHFAAQLIWIACFSFVSLLAWIWSSIITDILPLILAETPHAWIRSSQLVFASENWLPEFKPEGVTSHLRSSSPEGDDGSEISTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCJ5</accession>
    <name>A0A1Y1UCJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endoplasmic reticulum vesicle transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_603175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869935.1">
        <property type="nucleotide sequence ID" value="XM_022013958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCJ5"/>
    <dbReference type="FunCoup" id="A0A1Y1UCJ5">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCJ5"/>
    <dbReference type="GeneID" id="33555766"/>
    <dbReference type="InParanoid" id="A0A1Y1UCJ5"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="198"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="404" mass="44695" checksum="E2567C1B4D8589FE" modified="2017-08-30" version="1">MDMMYDPHLGSSGHNSRHDQEGSLLQELDKIAPIKSFDAFPKVQSTYVSQSRQGGVLTAIVSLLCIVLVLNDLGDYLYGPPDYAFQVDHGAETELQLNVDLTVAMPCHYLSIDLRDAVGDRVHLSNDFVKDGTSFNVGKASSLKLAAPTNPSASEVISSARRRTPNQRGSFAGLRRLFAAPGRAHHTGYRPTELVKNGPACRIYGSVNVKKVTANLHITTLGHGYMSMEHTDHSLMNLSHIVHEFSFGPFFPAISQPLDLSMEITDKPFTIFQYFLRVVPTTYIDSSRRKLVTSQQYAVTDYSRSFEHGGGIPGVFFRYDLDPMSLTIKERSTSFYQFFLRLTGAIVLCAGGVWTVAAFGMRIVNRAQRQVKRMGQKDSFESSSYSSGTSLSQRRVSRGNGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCT4</accession>
    <name>A0A1Y1UCT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Redoxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_652469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869524.1">
        <property type="nucleotide sequence ID" value="XM_022018500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCT4"/>
    <dbReference type="FunCoup" id="A0A1Y1UCT4">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCT4"/>
    <dbReference type="GeneID" id="33560309"/>
    <dbReference type="InParanoid" id="A0A1Y1UCT4"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="74"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="232" mass="24751" checksum="E3830E55BB4C0E3F" modified="2017-08-30" version="1">MQSVTAVARTTLLRSTVRQSTRTAVTPVRYLSSSRSTLHIPRTTSRNHKMASIVQSAAAAAHSAFATVASASQIKAGDSVPNVEIKVNDLEDKVNFSTLQGKNILVLVPGAFSGTCNSQVPGYIDRYDEFKSKGVENVYIVAVNDMFVMQAWKNKLAKDNGKETLPLLFAGDDAGKLASSLGIVFDAQAVFGGPRFMRAALVIDSGKVVHVGVEKSPGDITVSHADDIISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD09</accession>
    <name>A0A1Y1UD09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_629366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870008.1">
        <property type="nucleotide sequence ID" value="XM_022016204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD09"/>
    <dbReference type="FunCoup" id="A0A1Y1UD09">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD09"/>
    <dbReference type="GeneID" id="33558013"/>
    <dbReference type="InParanoid" id="A0A1Y1UD09"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="181"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="404" mass="44802" checksum="BCFA18A806A76F72" modified="2017-08-30" version="1">MSALASSSTVVAPAGMDPDKYEAIKAYRAKVKEHTEIGERLKRVRLNIQSLSGDFDKTEDDIKALQSVGQLIGEILKQLDDERFIVKVSSGPRYVVSYRPTLPAAKLKPGVRVSLDMTTLTIMRILPREVDPMVYNMSLEDPGAVSFAGIGGLGEQVRELREVIELPLMNPELFERVGINPPKGVLLYGPPGTGKTLLARAVAATLNTNFLKVVSSAIVDKYIGESARLVREMFAYAKENEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGKTKLIMATNRPDTLDPALMRPGRLDRKIEIPLPNEQGRLEILKIHAMKINKSGDIDYEAVVKLSDGFNGADLRNVCTEAGMFAIREDRDAIVQEDLMKACRKLRDAKKHETAMDYKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDL6</accession>
    <name>A0A1Y1UDL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870252.1">
        <property type="nucleotide sequence ID" value="XM_022016312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDL6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDL6"/>
    <dbReference type="GeneID" id="33558121"/>
    <dbReference type="InParanoid" id="A0A1Y1UDL6"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="50"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="236"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44953" checksum="3BF5D169280D045A" modified="2017-08-30" version="1">MYERGPYMMYRVISGLPQLDPLTMTVVPATDLPKYQYVPETTEDLDWAELPTIDLTTFGTSSEADKKLATNLLDAIRTKGFFYVIGYDIEQDRVDRQFAIGQKFYDLPLSEKSKYIPDLENGEYNGYRPAGRRVTSAGLKDQVEVYNIPKFNGDYAHEHPAVVATNLKEIEVFARDLHSKVLDPLFDLVSIGLGLPRSFFRDLHKYENHSEDHLRYMKYSKYSPEDRAKVLAGDGLYSYGHTDLGSFTLLFRQPVAALQIKDHQTGEWKWAKPLDKSFTVNSCDAFSFLTGNYIKSTVHRVHLPPDDQAQYDRLGLLYFARPQNDLVLKTIASPVLKEAGFTQNEFEREGHPVPTMGEFVHLKQKWQQSKSTDYLAKKDQIIVPGFKGEYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDV6</accession>
    <name>A0A1Y1UDV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_627981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870331.1">
        <property type="nucleotide sequence ID" value="XM_022016067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDV6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDV6"/>
    <dbReference type="GeneID" id="33557876"/>
    <dbReference type="InParanoid" id="A0A1Y1UDV6"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="463" mass="51875" checksum="BB5789FEC895D433" modified="2017-08-30" version="1">MPDDGYIPHARFVSPNEIRRDFCAALSSMYRLEVPLYGELIDLVNDVNERVKERGGSWETSARLGVERHGAIRLGRPSELAFIARFFATLGMYPVGYYDLSTSGVPVHATAFRPISSSALEANPFRVFTSLLRPELISDPMLRQQALDILAKREIFHPRVRELVTMAERQGGLGEDEAKDLVQFGLETFRWHETAFVDQATYRKLDQAHPLVADIVGFRGPHINHLTPRVLDIDTAQRDMIRREIPAKQIIEGPPARQCPILLRQTSFQALTEAIRFPGGEGLGAHRARFGEIESRGVALTPKGHDLYMKLMDELKRVEAHIENNDEHQANLQKVFARFPDSWKSLRKDRLAYFTYSLAFTSIGPGTPRSLEDLIDDGIVTVTPIVYEDFLPASAAGIFQSNLGSSSGSRSPTPEESSSSTESSKVVFEEALGQTTIDYFELYEQIQQKSLDTVRRLTGGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDW0</accession>
    <name>A0A1Y1UDW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Endoplasmic reticulum Ca-transporting P-type ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_631324</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869868.1">
        <property type="nucleotide sequence ID" value="XM_022016421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDW0"/>
    <dbReference type="FunCoup" id="A0A1Y1UDW0">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDW0"/>
    <dbReference type="GeneID" id="33558230"/>
    <dbReference type="InParanoid" id="A0A1Y1UDW0"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="13">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="263"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1221"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX35704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1247" mass="138149" checksum="869250C36BED2210" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC2</accession>
    <name>A0A1Y1UEC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870006.1">
        <property type="nucleotide sequence ID" value="XM_022016202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEC2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEC2"/>
    <dbReference type="GeneID" id="33558011"/>
    <dbReference type="InParanoid" id="A0A1Y1UEC2"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="310" mass="33908" checksum="9BFF63A519F0BF1D" modified="2017-08-30" version="1">MVAKEERISFKNGPNRLVGILRSPESGSVSVKLPALIMVTPGSSVKEQIGSNYARAMVEHGFVTLTFDPCHQGESEGFPRDLENPAVRIEDVVCAVDYLSTVSTVDEEKIGLIGICAGGGYAVGAAKIDHRVKALGAVVPVNIGRAFRQAQSNPGAMLATLEAVGKQRNVEMQGGEQVRVPWIPGSVEEAEKQGVDIDTMDAVKYYRTPQGQHPKSTGKLLMTSNAFLLGFDAFNLVEELLTQPVQVIVGGRLGLTFSYADGKTLWEKCQKKEEFVVIKDAGHYELYDKREYVDQAIEYLVAFFKKHLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEG2</accession>
    <name>A0A1Y1UEG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_643066</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869655.1">
        <property type="nucleotide sequence ID" value="XM_022017522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEG2"/>
    <dbReference type="FunCoup" id="A0A1Y1UEG2">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEG2"/>
    <dbReference type="GeneID" id="33559331"/>
    <dbReference type="InParanoid" id="A0A1Y1UEG2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="414" mass="43226" checksum="082F13EB73A1158A" modified="2017-08-30" version="1">MLTRGFQTLVSSSSSSINRIAQRSMSTQSVYIVSASRTPVGSINGSLSTLSAPQLGVVAVKHALEKAGVKPDQVEEIYMGNVVQAGVGQSPARQVGLGAGIPESTDATTINKVCASGMKSITLASQAIQLGQRGIMVAGGMESMSNAPFLVPRRNPAFGNMEAKDSLVSDGLNDVYHKFPMGNCAENTAEKLSITREDQDDHCLSSYTRAEEAWSKGLFKDEIAPVTVKGRKGDTVVEEDEDYKKLLKDKFRNLKGAFKKENGTVTAANASTLNDGASAVVLASGDVVEKEGLKPIAKILGYADAACAPIDFPTAPTLAVPIALKNAGVSKDDIALWEFNEAFSVVAVAAEKVLELPREKVNVRGGAVALGHPIGSSGCRIVVTLAHALKKGEKGVAAVCNGGGAATAIVIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF13</accession>
    <name>A0A1Y1UF13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_651119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870702.1">
        <property type="nucleotide sequence ID" value="XM_022018272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF13"/>
    <dbReference type="FunCoup" id="A0A1Y1UF13">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF13"/>
    <dbReference type="GeneID" id="33560081"/>
    <dbReference type="InParanoid" id="A0A1Y1UF13"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="491" mass="54427" checksum="F2A2E47F8DFCDEAE" modified="2017-08-30" version="1">MTNDVKLPSDAPVVYESQDSMRIYRLNRPKALNSLNHEMITSLRTEIKKWRQSDLCRVIVARGDERAFCAGGDVKSLIQDLKKGDAAQNIALPFFKDEFELNWLLARLGKPYVSLMDGIVMGGGCGIALPAPIRIATPRTHFAMPETKIGYAPDVGVNYYLAQLDGNLGAWLAITGHDLYGRAVYELGLATHYVSESALDSIVQEIQQLSNPNLTQVSNIIANHTSPVPPRSAALSSKESRDGHSPIKGEIMAFLDRAFDCETIKEIYEKLDRASNDFELSEEVRAWAREQKTIMDARSPTGMAVALEGYRMAKNAKRLDVTLDNDMSMATAFAGKNRSTNDFVTGVSSLLIEKSRDRPHWQPNDISDPAVSPADIKAKFFDLKGEIKEHRPELDLQPPSVSEKTKGPDSTWGQFGRYGLPSQLEVMAKVEGYAPSAGAFKVTEAELIDRVLDDRGESGGPRETEMQAKVKDLVSRLCEVKEGGYLDWRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF49</accession>
    <name>A0A1Y1UF49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_626649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870711.1">
        <property type="nucleotide sequence ID" value="XM_022015917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF49"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF49"/>
    <dbReference type="GeneID" id="33557726"/>
    <dbReference type="InParanoid" id="A0A1Y1UF49"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010995996" evidence="4">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="329" mass="36456" checksum="1D195D6E84BC2A02" modified="2017-08-30" version="1">MIASAWLLGCLTALLRVATARDCPHILSCTVGAEQADPCCVPSPGGLIVFRQRFEPDKGSDEGTWGVDGLEVLDCAGQTSQDLQPFGPSYQHEEIASFCLRSDVFGGQRSFDQAEGEWAQSEVGEGVEEVWERSWNTAGRFISTIGPSCMPAGQGVASFFHTLHKLHSAFPTADLLSNADISPSPDTTYTLAEILDALKFKSHQPIVECDNMTLSSVLWPLQIQDTFQGGFVVPSFLLERKSSCPVEGIIFPPATTRPAPTTSHTWDPITRPTPRAISLDHDDSKLYFLPEQKVPQHDPRRLGVFKAGDEDREEDKEGRYWKRYRRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF79</accession>
    <name>A0A1Y1UF79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_631400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869889.1">
        <property type="nucleotide sequence ID" value="XM_022016432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF79"/>
    <dbReference type="FunCoup" id="A0A1Y1UF79">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF79"/>
    <dbReference type="GeneID" id="33558241"/>
    <dbReference type="InParanoid" id="A0A1Y1UF79"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="434" mass="47474" checksum="31B5E010D8EE74E9" modified="2017-08-30" version="1">MGSVQKQKAVIIGSGIFGMSTALWMLKDGSYDVVILEKCETVPAPDAASSDLNKIIRAGDYIDPATSELALEAVEMWKQPEWEGTYHESGVMCISAKDDKQGEKFLQFAYKNLHDHNIDAVMCPDLQGIKAQFKGDVPVGTFGGKHAYFNPIGGWAEAERGVEAGHKQIRKLGGVIRSGCEVAKLIVDGRRIGGVVLKTGEEVRGDLVVAAAGSWTSQLFTSIGVGRMPKVEATGHSLACVQLTPEEAKVYAGAPVVFSTDKGFYVFPPNPDGLVKFAIHAAGYTNPLPESNGVSVPRTKLTPGAEEGMIPLTEMRLLREQLATIYPELAKKDFVQTRMCWYCETKYGDWLIDYHPDFDNLVFATGGSGHAYKFAPIIGREILKVIQRRPDPRFAARWSFDGIDEDTGADFKHDKVQLLVVDELTTRDDLKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFD5</accession>
    <name>A0A1Y1UFD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_675232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870807.1">
        <property type="nucleotide sequence ID" value="XM_022018950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFD5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFD5"/>
    <dbReference type="GeneID" id="33560759"/>
    <dbReference type="InParanoid" id="A0A1Y1UFD5"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012010939" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="21535" checksum="02ED94FF78D95961" modified="2017-08-30" version="1">MLARSLLLTALAGSSMAQLLVNTISSLIVCQPALITWSGGTAPYFLAVIPGGDPSGIALKNFPQQSGTQLTWDVDIAAGTSVTIKITDSSGAVNYNSQVTIQPGSTTACIGQDDASGGAAAGAAAASGASGDSTVSGTSAGSVVVSSAVASGSSAAAASRSSASAANAVAAQSASGSRPASASTSRTPSSSNSAASGSTTSGAALPLAISNKATPLIAVIGAVAAMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFT3</accession>
    <name>A0A1Y1UFT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_627712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870990.1">
        <property type="nucleotide sequence ID" value="XM_022016032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFT3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFT3"/>
    <dbReference type="GeneID" id="33557841"/>
    <dbReference type="InParanoid" id="A0A1Y1UFT3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="505" mass="54873" checksum="DC3819CC949DCAA8" modified="2017-08-30" version="1">MSTVDHHLTSVPSGSFNVDTLSEEERQTRYRKVVRKLDCIILPLTAALYLCAALDRGNIGNAKLQGLQDILGGNTTAEKSTHFSIALMSFYVTYILFNVPGNILATMITPNKSLALGAIVWGVASTAQAGCTSLAGIVVCRLFIGIGESAFGVAVALYYSLWYTRDQLAKRLSLYIGMGSIAGAFGGLIAYGVSFIKTSKPAHWQILFIIEGLPSVILSVVIFFFLPSVPESSKYLSTEERAILAHFLKDPGYARKHHFDRTAFKRVFTTPTTYLNCLVYMGLSLSLGSVSGFLPTIIKSLGYSAAQAQLFTVPPYAVAFVGTLSVSFLSDRYRSRGIPIAGLAIASAVGFAILIAVPHNMAVRYFAVFPTVLGVFSVGPLMMTWATNTAGSHSAAAIRLGFMNGVGQSFSILSSFMFPAEEGPHWYKGFSLNIAFNIVMVCAALTLTTIYRRENARRDNEQLGEAAISGNPEQEKANMEHIEDDEEDSPDAHLHDLSPNFRYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFV4</accession>
    <name>A0A1Y1UFV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpC/TSA antioxidant enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870971.1">
        <property type="nucleotide sequence ID" value="XM_022018325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFV4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFV4"/>
    <dbReference type="GeneID" id="33560134"/>
    <dbReference type="InParanoid" id="A0A1Y1UFV4"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="637" mass="70802" checksum="CFA1A3294458F82C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFY7</accession>
    <name>A0A1Y1UFY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_642580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870548.1">
        <property type="nucleotide sequence ID" value="XM_022017496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFY7"/>
    <dbReference type="FunCoup" id="A0A1Y1UFY7">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFY7"/>
    <dbReference type="GeneID" id="33559305"/>
    <dbReference type="InParanoid" id="A0A1Y1UFY7"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="373" mass="41755" checksum="B5CC8AA30D84C04B" modified="2017-08-30" version="1">MADMDDPVASGSRLFTAPVKRIVSSAHLQVFKSSSTHDELFDFILRLNNSVIDKTLTSVGEPSSAVTRSLLDILNAVHELACATPAVDNTLSRFGNPAFRTFYDKVAEASGRLHAMIPGLSAEAVPELEVYFKQSWGSRERIDYGSGMELNFVCWLLCLHKMGLVRDDDSTFLVLGIFWRYIKVMRYLQSTYWLEPAGSHGVWGLDDYQFLPFLWGSAQLRDHKHLRPKAIHDEEILEAFAPAYMYLSCIKFINSIKTASLRWHSPMLDDISAVKTWSKVNSGMMKMYDAEVLGKLPVMQHMFFGSLLPFPEDPQLPNMPGDLEHGHVHEKGWQMDCCGIPGECNSARAVPDVAVPSAFGQAHQAGLKPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFZ6</accession>
    <name>A0A1Y1UFZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_628896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870558.1">
        <property type="nucleotide sequence ID" value="XM_022016154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFZ6"/>
    <dbReference type="FunCoup" id="A0A1Y1UFZ6">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFZ6"/>
    <dbReference type="GeneID" id="33557963"/>
    <dbReference type="InParanoid" id="A0A1Y1UFZ6"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111858" checksum="ECC263495E6D647E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGV1</accession>
    <name>A0A1Y1UGV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_590570</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871328.1">
        <property type="nucleotide sequence ID" value="XM_022013790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGV1"/>
    <dbReference type="FunCoup" id="A0A1Y1UGV1">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGV1"/>
    <dbReference type="GeneID" id="33555598"/>
    <dbReference type="InParanoid" id="A0A1Y1UGV1"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="216"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX37290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="486" mass="52422" checksum="2990E5816150556B" modified="2017-08-30" version="1">MSTQPLSAMLSGLYLGPSDSPTPDPGSRSIFLASKSAATTTLSATTSSASTAVNPGTGNRLPPVMKKYMNPNLVRPPNTAVSQHSSSFSANPASITSGINKEAIRGPLLKLAGVNVPSPSRVPSGGKMPPKTHTAHGIHGPAHSTSKRLSSVGGATGQHTSSAGTTGGAKKIELGKYDGGLEADEGEDVGIPADAGRMLELDSSSSGTIPLSLTAFTIGRPLGKGKFGRVYLARTKAAPHFIVALKCLHKSEIVNGKVEKQVRREIEIQQNLRHPNILRLYGYFHDSKRIFLILEFAVKGELYKQLSKYGKFEEKRASRYIAQMADALSYLHKKHVIHRDIKPENLLIGLKGELKIADFGWSVHAPSNRRQTLCGTLDYLPPEMIEGKEHNAKVDLWAIGVLAYEFICGGPPFEDLSGNSATYKRICKVDLKIPDHVSPEAADLIRKLLRYNPEERLPLADVLAHPWIKKYEKKSSTGGSGAARDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGW1</accession>
    <name>A0A1Y1UGW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_651555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870416.1">
        <property type="nucleotide sequence ID" value="XM_022018353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGW1"/>
    <dbReference type="FunCoup" id="A0A1Y1UGW1">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGW1"/>
    <dbReference type="GeneID" id="33560162"/>
    <dbReference type="InParanoid" id="A0A1Y1UGW1"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="38779" checksum="C81ACEB2F788A1F0" modified="2017-08-30" version="1">MSVATARPPIAGAGSSTSVHHRAGPSRKTGPPAGFEVLSVYQAALAADLPAPIAAIMTLVSLMEASSSTTMTGLASEVNAGTEILQDNQANLGVRAGCQLWERFFASSGGGPEDFATVKKSLINQGKQFCHVTAPACREKIATLAADFLVDGCTVLTHGFSRTVILTLLKAHKQSKRFNVYITEGRPSGMGMRTHNVLTKAGIPCVVVLDSAVSYVMDRCSMVLVGAEAVVESGGIVSYIGTYQLALVARAMQKPFYALAESYKFLRHYPLSQTDIPRPKHTGIPLLFTHDILRTPSKPDSAMDEAKSRVSKDVRVEMTEGMEEQNPLVDVTAPELIDFIFTDLGAPLSPTSVSQYLVAQFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGZ4</accession>
    <name>A0A1Y1UGZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamin diphosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_580603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870456.1">
        <property type="nucleotide sequence ID" value="XM_022013447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGZ4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGZ4"/>
    <dbReference type="GeneID" id="33555255"/>
    <dbReference type="InParanoid" id="A0A1Y1UGZ4"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="583"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="934" mass="103571" checksum="E6F05B76534730AF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH16</accession>
    <name>A0A1Y1UH16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUC071 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_580195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870865.1">
        <property type="nucleotide sequence ID" value="XM_022013427.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UH16">
        <property type="interactions" value="952"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH16"/>
    <dbReference type="GeneID" id="33555235"/>
    <dbReference type="InParanoid" id="A0A1Y1UH16"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2101"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2336" mass="269265" checksum="09053E95CF35DFF1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH17</accession>
    <name>A0A1Y1UH17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870886.1">
        <property type="nucleotide sequence ID" value="XM_022018307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH17"/>
    <dbReference type="GeneID" id="33560116"/>
    <dbReference type="InParanoid" id="A0A1Y1UH17"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012395186" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47526" checksum="1BBC7B321897527F" modified="2017-08-30" version="1">MFASQLATAALFGATCALAAPLNSQDERSTVSDLVGLSPVTPTQLAITIDPNFQRDSCITATKLIDGRVFWICRDTLNLQNETLNEYIGFIESSSASWSNQTAAGNAPVLTPVPASQGQKPVTSGFSQQLTQYGGPFPLTTPYLYYAPDQYPPGGAGPDFSRYEEWPDAPLYITDVASDGTTTGYLFPTAAANGGNITDEFPGTTLYKITYTPTSNLSTLPTVEMIAEHFFPRYGFNYGAFGGVISPTDNMLYLWGETYAFYGLFVQNPVYNVSLGLARVALDSIENIDAYEYYYPATNTWNETQPNIYNKAANVTVGYITGQGTFFYNEKESVYVFVGQNQNETNMEVTYSVAQQPEGPWSLAAPPVTLSNDFSYSLAAHPEMGDDPNNLYVSFTANFDDSTGKNQYKQPLYQLQFDWTNLDGVLQSLPKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH24</accession>
    <name>A0A1Y1UH24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_625776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871386.1">
        <property type="nucleotide sequence ID" value="XM_022015839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH24"/>
    <dbReference type="FunCoup" id="A0A1Y1UH24">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH24"/>
    <dbReference type="GeneID" id="33557648"/>
    <dbReference type="InParanoid" id="A0A1Y1UH24"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="598" mass="66496" checksum="3C733356A8848110" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH83</accession>
    <name>A0A1Y1UH83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_681313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871461.1">
        <property type="nucleotide sequence ID" value="XM_022019114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH83"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH83"/>
    <dbReference type="GeneID" id="33560923"/>
    <dbReference type="InParanoid" id="A0A1Y1UH83"/>
    <dbReference type="OrthoDB" id="2575563at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="964" mass="104271" checksum="580FA925ED63EE4B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH90</accession>
    <name>A0A1Y1UH90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF333 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_579295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022013372.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2555955at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
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    </dbReference>
    <dbReference type="InterPro" id="IPR005590">
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    <dbReference type="PANTHER" id="PTHR38008:SF2">
        <property type="entry name" value="HEMOLYSIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03891">
        <property type="entry name" value="DUF333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8537" checksum="96014AD3E1031CC1" modified="2017-08-30" version="1">MVANPASVYCIEIGGTLEIRKDGEGNEVGYCKLPDGSEVEEWELFRTAHAEESKSAEDRSSQAGQMGTGGSDDQKVLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH92</accession>
    <name>A0A1Y1UH92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PinX1-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_444260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871397.1">
        <property type="nucleotide sequence ID" value="XM_022012799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH92"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH92"/>
    <dbReference type="GeneID" id="33554607"/>
    <dbReference type="InParanoid" id="A0A1Y1UH92"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="358" mass="38067" checksum="5F6999E3672509C2" modified="2017-08-30" version="1">MGLSERKNKQRIGLDPRNLTWSNDTSRFSYQHLKSLGWSSSSGIGGSGLDGNPNHIAVVKKLDNGGIGMARARKEGDDNAAGAGPAGRNFEDVLKRLAGNSPSESPSGASTPVEQAVEKKRNKIASRQKHLQSKRLASSSPAALAEILGVPVSSLPASPLQSTPTTPAPVDTPSPATPSDPTEPERTVEEGISKSTLSVSDYFRQKMRDKMKARQGMSGDSPGPPAEPLALKGTDPWEGSRTTFEETESGEGSSSSPAVNPTATTVTADDEKAAKKAKKEARRQKKMAKTSDEGVTANANAGTSDNLPALPAVVEGPSKKDKKEKKKRKLETEQDVTEVVESSSDRDEKKKKKKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHS8</accession>
    <name>A0A1Y1UHS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871598.1">
        <property type="nucleotide sequence ID" value="XM_022018113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHS8"/>
    <dbReference type="GeneID" id="33559922"/>
    <dbReference type="InParanoid" id="A0A1Y1UHS8"/>
    <dbReference type="OrthoDB" id="2562784at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="766" mass="80843" checksum="33D69D292B375C6E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHV8</accession>
    <name>A0A1Y1UHV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_680547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871628.1">
        <property type="nucleotide sequence ID" value="XM_022019083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHV8"/>
    <dbReference type="GeneID" id="33560892"/>
    <dbReference type="InParanoid" id="A0A1Y1UHV8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="241" mass="26271" checksum="62F81B6E3439AA12" modified="2017-08-30" version="1">MSEMTPFSAASASHVSIPVTLKVDESDPIAGADENARQELCKSIFLGAVPCTVATNHGQQWFVEATLPQSRTFHGTDAEADDGMFDYRYNFGATVSDICHQTDRALVDRIHALSTQNKISVYAKLVDFTPATDTEPGYILPQADVSVQLSQNADDEVQIQSSPGQRFIASNSRWTLSVVPSSISDDLGLEEADRARLQAFTWDGLGTIMVGLEGTDRVPLDMDVSDAGSADQLQRKRQRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHW7</accession>
    <name>A0A1Y1UHW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_578466</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871638.1">
        <property type="nucleotide sequence ID" value="XM_022013325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHW7"/>
    <dbReference type="FunCoup" id="A0A1Y1UHW7">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHW7"/>
    <dbReference type="GeneID" id="33555133"/>
    <dbReference type="InParanoid" id="A0A1Y1UHW7"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX37651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="281" mass="31862" checksum="A830F86701F31CA0" modified="2017-08-30" version="1">MLKTALRSVASTSRQSNLALRSFTSSPITAFAQPSNETPTPPPGKVPQMKEFKIYRWNPDQPAEKPKLQSYSIDLSQCGPMMLDALIKIKNEVDPTLTFRRSCREGICGSCAMNIDGVNTLACLSRIPKDTKPSKIYPLPHMYIVKDLVPDLTNFYKQYKSIEPYLKNDNPPAKGEFLQSQEDRKKLDGMYECILCACCSTSCPSYWWNQDQYLGPAVLMQAYRWMADSRDAYGAQRKEKMQNSMSLYRCHTIFNCSKTCPKGLNPAMAIAKMKLEMAQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHY5</accession>
    <name>A0A1Y1UHY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871185.1">
        <property type="nucleotide sequence ID" value="XM_022015754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHY5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHY5"/>
    <dbReference type="GeneID" id="33557563"/>
    <dbReference type="InParanoid" id="A0A1Y1UHY5"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="168" mass="17859" checksum="0EE04F8F1967AF80" modified="2017-08-30" version="1">MSSLQAPRRILTSHTSSGEVEIQDDALRGFPVGDGMTMSLAYVQKGFPADPKMAIEGVGSMPDGPFQSDGTVAAFLDFEAGKKTPMHFTKTLDYLLVISGELTLTLHDGTAKTVKAGELVVQAANVHQWSNETSETARTFAVVIPSKAREIEGKNLTDALGAQEGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI97</accession>
    <name>A0A1Y1UI97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AFG1-like ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_622967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871696.1">
        <property type="nucleotide sequence ID" value="XM_022015534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI97"/>
    <dbReference type="GeneID" id="33557343"/>
    <dbReference type="InParanoid" id="A0A1Y1UI97"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="648" mass="73134" checksum="D74FBC66E149B586" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIA7</accession>
    <name>A0A1Y1UIA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_579035</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871775.1">
        <property type="nucleotide sequence ID" value="XM_022013353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIA7"/>
    <dbReference type="FunCoup" id="A0A1Y1UIA7">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIA7"/>
    <dbReference type="GeneID" id="33555161"/>
    <dbReference type="InParanoid" id="A0A1Y1UIA7"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="114"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="583" mass="62441" checksum="88DD929243957E81" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIF0</accession>
    <name>A0A1Y1UIF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_436939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871302.1">
        <property type="nucleotide sequence ID" value="XM_022012782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIF0"/>
    <dbReference type="FunCoup" id="A0A1Y1UIF0">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIF0"/>
    <dbReference type="GeneID" id="33554590"/>
    <dbReference type="InParanoid" id="A0A1Y1UIF0"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012372538" evidence="1">
        <location>
            <begin position="22"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="366"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="617" mass="69351" checksum="8A12F0653C05FE94" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIL0</accession>
    <name>A0A1Y1UIL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_650433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871877.1">
        <property type="nucleotide sequence ID" value="XM_022018143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIL0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIL0"/>
    <dbReference type="GeneID" id="33559952"/>
    <dbReference type="InParanoid" id="A0A1Y1UIL0"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="210" mass="23498" checksum="2715082F5C4D708B" modified="2017-08-30" version="1">MSTPLLQQFPSLAHYPSSFLKDLLSSPQLTEAFLYTLPEVQQLAEEVEKLGRENEEIAHRNLELRDELIALRDATAQSYAHAEGQKARWADIEKAQTALYQRHRPSFLHLRLKHSITAQDDLSERIASSFIEGKNGGSQRTTPVGGAADGCGPGSRVDSPAFGHGDASTPNGTKSIEDFIQDFKAARKVYHKRAIWAERWTRGEVAWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIN5</accession>
    <name>A0A1Y1UIN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_625814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871394.1">
        <property type="nucleotide sequence ID" value="XM_022015844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIN5"/>
    <dbReference type="FunCoup" id="A0A1Y1UIN5">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIN5"/>
    <dbReference type="GeneID" id="33557653"/>
    <dbReference type="InParanoid" id="A0A1Y1UIN5"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="290" mass="30468" checksum="EF6801801AC3C7A7" modified="2017-08-30" version="1">MTSVPPAAAPTAVPAANAGGAASSGYTIHVAGLAPETSEEKLHDFFSFCGKLVSVKKNGSTADITFEKLSAMRTSLMLNGGTLDGAHLEVTSTTEETKSSVLPTESTHAATHGEISQEDKPKAAIVAEYLAHGYVMGDHVIQRAIDFDHEKGISNRFLSFFNNLDKTVGNKVVGEDKTVSGKINEGAAAVVAKTREVDQNRGVSAKFQDYYNRIVSTPVGQKVHAFYTTTQKQVLDVHEEAKRIAEEKKRASGVATPSATATSTTEAAPVTAATTTAPISTTAATSDPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU2</accession>
    <name>A0A1Y1UIU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871970.1">
        <property type="nucleotide sequence ID" value="XM_022018162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU2"/>
    <dbReference type="GeneID" id="33559971"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="199" mass="22788" checksum="022F0A676A3DDA15" modified="2017-08-30" version="1">MSSQVKEEEHSSHTMSQYSVPPQHKSLQVTGTDPTDPSVTGSVESNIQLRYRELEESSDFKGEAAELMKEEWNLTDEAASRAAESLNKEVDLYLKSFKRQISERHSKRFPESGELALTMIYRGIKSVKLYRYETSEKTLALLYRFQAGSSGIANLPFRVTRSENDQWEVTFDQMAAQELKGGYQEHSRDEAIPSCFKCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIU4</accession>
    <name>A0A1Y1UIU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_624531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871063.1">
        <property type="nucleotide sequence ID" value="XM_022015712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIU4"/>
    <dbReference type="GeneID" id="33557521"/>
    <dbReference type="InParanoid" id="A0A1Y1UIU4"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14359" checksum="21AFDBAE7CAFA40A" modified="2017-08-30" version="1">MPFITSGPSLRRLPLFFAYCPDYAGVLAKRLEVRPKHWARVQKEAEEGLHEFGLGYLPPPESSSTLPADVPSSTPLMDGSLMVFRAISLDHAWKRIKEDIYYTDGVWDKEKCVVREFIKHEKYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ34</accession>
    <name>A0A1Y1UJ34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_600605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872070.1">
        <property type="nucleotide sequence ID" value="XM_022013919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ34"/>
    <dbReference type="GeneID" id="33555727"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ34"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="558" mass="61910" checksum="05AEBE2815413F3F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJE5</accession>
    <name>A0A1Y1UJE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_625396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871283.1">
        <property type="nucleotide sequence ID" value="XM_022015796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJE5"/>
    <dbReference type="FunCoup" id="A0A1Y1UJE5">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJE5"/>
    <dbReference type="GeneID" id="33557605"/>
    <dbReference type="InParanoid" id="A0A1Y1UJE5"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="37"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="632" mass="69696" checksum="EE3EC65AE3BD614C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJL9</accession>
    <name>A0A1Y1UJL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_623092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871724.1">
        <property type="nucleotide sequence ID" value="XM_022015547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJL9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJL9"/>
    <dbReference type="GeneID" id="33557356"/>
    <dbReference type="InParanoid" id="A0A1Y1UJL9"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="359"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="933" mass="104092" checksum="F3CA2730749FD14A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJY8</accession>
    <name>A0A1Y1UJY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872302.1">
        <property type="nucleotide sequence ID" value="XM_022018041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJY8"/>
    <dbReference type="GeneID" id="33559850"/>
    <dbReference type="InParanoid" id="A0A1Y1UJY8"/>
    <dbReference type="OrthoDB" id="2596551at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="853" mass="95449" checksum="2741D57608C02ECF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK77</accession>
    <name>A0A1Y1UK77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872321.1">
        <property type="nucleotide sequence ID" value="XM_022015313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK77"/>
    <dbReference type="FunCoup" id="A0A1Y1UK77">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK77"/>
    <dbReference type="GeneID" id="33557121"/>
    <dbReference type="InParanoid" id="A0A1Y1UK77"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="190" mass="21623" checksum="0013B929807F33AC" modified="2017-08-30" version="1">MSIIRPFELQDVLKFNSINVDAWTATYHTGYYASYLAQWPDFCVAVQGSFDDTLAAYLISKHEPPPPDNLHHGHVTALTIKPEYRGLGLAHILIDMLERLSSSGTDCVDAWFVDLFVRCNNTRAIEMYEKMGYSVFRRVVDYYTGMEGVGSTKDELDGFDMRKSMPKDTTKRHVRSNGRDILVSADQVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKG1</accession>
    <name>A0A1Y1UKG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_624093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871981.1">
        <property type="nucleotide sequence ID" value="XM_022015660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKG1"/>
    <dbReference type="FunCoup" id="A0A1Y1UKG1">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKG1"/>
    <dbReference type="GeneID" id="33557469"/>
    <dbReference type="InParanoid" id="A0A1Y1UKG1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="372" mass="42669" checksum="B8032A07012AE87E" modified="2017-08-30" version="1">MGEEEDQYEGPSFDLNNIPFNVSENYDVHSIVGEGAYGVVVGAVHIASDTKVAIKRITPFDHAMFCQRTLREIRLLRHFRHENIISILDIIPPMSYESFTEVYLVQELMETDLHRVIRTQELSDDHCQYFIYQTIRGLKALHTADVLHRDLKPSNLLLNANCDLKICDFGLARSAAAPVRDGNGGNGFMTEYVATRWYRAPEVMLSFQEYTKAIDMWSVGCILAEMINGKPLFPGTDYHDQLALILDVVGTPTMDDFNEITSDKSKDYLRSLPFTRRRNLALLCPKAKPYALDLMKKTLTFSPTKRWTVEEALNHPYLEPYHDPNDEPGAPPLAYDFFNFDDRADQLDRHMLKRLIYAEVLKPLYDSNGQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKG4</accession>
    <name>A0A1Y1UKG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_364636</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872463.1">
        <property type="nucleotide sequence ID" value="XM_022012589.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UKG4">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKG4"/>
    <dbReference type="GeneID" id="33554397"/>
    <dbReference type="InParanoid" id="A0A1Y1UKG4"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="245"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1593"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1593"/>
            <end position="1755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX38541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1788" mass="196126" checksum="FD9E1DD868342D80" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKK2</accession>
    <name>A0A1Y1UKK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_621504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872512.1">
        <property type="nucleotide sequence ID" value="XM_022015386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKK2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKK2"/>
    <dbReference type="GeneID" id="33557195"/>
    <dbReference type="InParanoid" id="A0A1Y1UKK2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="293" mass="32834" checksum="D1E664CC1056B57C" modified="2017-08-30" version="1">MSEDMSQLTIKSTFKLLSGNTIPRFGLGVYQSRGEECFEAVKEALKADYRHVDSAQMYRNEELVGKAVIESGVPRSEVFITTKYNPNHKIRTTEDVYQDLKSSLPKIDPSSEGANGSKPYIDLMLIHAPWGGDEGRGNNWAALAKAQKEGWIKDIGVSNFGAKQLENLPEPVPVINQIELHPWCQQRPTVAYCQKKGIAVEAYTPLVQAHKERFQEPKLLSICKKHGKDQAQVLIRWSLQKGYVVIPKSVTPSRIRSNAQVYDFNLDKEDMDALDSLDMGADGAVTWNPVDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKX3</accession>
    <name>A0A1Y1UKX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_599654</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872622.1">
        <property type="nucleotide sequence ID" value="XM_022013907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKX3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKX3"/>
    <dbReference type="GeneID" id="33555715"/>
    <dbReference type="InParanoid" id="A0A1Y1UKX3"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="655" mass="72230" checksum="BCC4F20C51D81EAA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL57</accession>
    <name>A0A1Y1UL57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_620271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872209.1">
        <property type="nucleotide sequence ID" value="XM_022015265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL57"/>
    <dbReference type="FunCoup" id="A0A1Y1UL57">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL57"/>
    <dbReference type="GeneID" id="33557073"/>
    <dbReference type="InParanoid" id="A0A1Y1UL57"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="190" mass="22337" checksum="DAA344D1959B372B" modified="2017-08-30" version="1">MGKAQSKLTSEELSELQKNTYFDKKELQQWYKGFIKDCPGGQLNKEEFQKIYRQFFPFGDPSQFADYVFNVFDEDKSGTIEFKEFICALSVTSRGRLDEKLKWAFQLYDINNDGEITYDEMLQIVRSIYKMTGQMVRLPEDEDTPEKRVDKIFRTMDLDKNARLSYEEFKEGSKQDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL84</accession>
    <name>A0A1Y1UL84_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_648927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872676.1">
        <property type="nucleotide sequence ID" value="XM_022017906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL84"/>
    <dbReference type="FunCoup" id="A0A1Y1UL84">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL84"/>
    <dbReference type="GeneID" id="33559715"/>
    <dbReference type="InParanoid" id="A0A1Y1UL84"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012734003" evidence="9">
        <location>
            <begin position="19"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="155"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="380"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="631" mass="70329" checksum="27D3F075CC846A37" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULN1</accession>
    <name>A0A1Y1ULN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872814.1">
        <property type="nucleotide sequence ID" value="XM_022017929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULN1"/>
    <dbReference type="GeneID" id="33559738"/>
    <dbReference type="InParanoid" id="A0A1Y1ULN1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012372545" evidence="3">
        <location>
            <begin position="31"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="483" mass="54370" checksum="04B482EE6DA5F310" modified="2017-08-30" version="1">MPRSSASLARSSMTLTLFLAGSTLLPRGESRSSDDDDEKGYTKGYKFDKQDSDDGSWRDNKYDDGDDDYSTTHKTKWWTASETASESPWSATVSPSATTTKWHKSTSTWSSSTSTALSSTTSPSPNNLLTTLLPAQASDSASPQARQVNPVAIAVPLAICGLIGFIALLFCAKKRSAKTRSAPQPSDIEKELQSLILRQQTITSGQSRASDGVTITKRDGGQVSDNDSRHPPSVRRSESYFAEEDRRRAMDMEYTHARSYRSDSRHDSHHQEPFSRSETPSYRSYPSSHSDTCVTPTDSRSMHDRFTRLPSRSRFSQLYSDVQRPDRHDIDYYAPTRKSAPNPGGFPMIECECSSCRQGYLHRPRDHFLNRQPSLLSKRTNTDNGSLANPYSKTEDHYDIFESYYRPKSLRLSRPFASHSTQGYRSEMERLIAKQSQYRLSEPLTRDHSLGSSMDSRYARSQGHSADGLYESLRVALEAPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULU6</accession>
    <name>A0A1Y1ULU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_618258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872884.1">
        <property type="nucleotide sequence ID" value="XM_022015005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULU6"/>
    <dbReference type="FunCoup" id="A0A1Y1ULU6">
        <property type="interactions" value="634"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULU6"/>
    <dbReference type="GeneID" id="33556813"/>
    <dbReference type="InParanoid" id="A0A1Y1ULU6"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="210"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="516" mass="57488" checksum="2A423690E8B2C0FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULW1</accession>
    <name>A0A1Y1ULW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_621194</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872439.1">
        <property type="nucleotide sequence ID" value="XM_022015364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULW1"/>
    <dbReference type="FunCoup" id="A0A1Y1ULW1">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULW1"/>
    <dbReference type="GeneID" id="33557173"/>
    <dbReference type="InParanoid" id="A0A1Y1ULW1"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000446">
        <property type="entry name" value="Microtubule associated serine/threonine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="312"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="613"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX38517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="706" mass="78899" checksum="CC38E39AD7E78F67" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UME3</accession>
    <name>A0A1Y1UME3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_655891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872586.1">
        <property type="nucleotide sequence ID" value="XM_022018829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UME3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UME3"/>
    <dbReference type="GeneID" id="33560638"/>
    <dbReference type="InParanoid" id="A0A1Y1UME3"/>
    <dbReference type="OrthoDB" id="2594947at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF20">
        <property type="entry name" value="PER-HEXAMER REPEAT PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013141396" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="29854" checksum="C609B30C63D196CD" modified="2017-08-30" version="1">MLSTSGLFVLSAVIGAAVVKSQAAPNWIYIPAACQSQCAVTLEAAYLCQNQFAGDTTQIYGCFCNDFPSDAASCASCLDSSNAGALGALLTSTVTACPQAVQSCFFACSFNTCETSDVACQCDAGYLENIYNCGSCNTANGNTGATQLSDWQTLEASCKAQNYPGANQSFTTVPLPMPVTDNYVAPVLTASGGGVAATGDYQATDGALAATATATAASGGSTAGSGTVGSGSSSGSGSGSGSGSGSGSGLGSGSGTGSGSGSGSGSGSGSGSVSGAGSAPTVVTAAQTTGGASPKALPAMGAMLALIGAVVAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNQ2</accession>
    <name>A0A1Y1UNQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="12" type="ORF">BD324DRAFT_586649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNQ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UNQ2">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNQ2"/>
    <dbReference type="InParanoid" id="A0A1Y1UNQ2"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="278" mass="31356" checksum="CCBB743E841EEB78" modified="2017-08-30" version="1">MTKRLREDEAGPSVPLKGSTQLHIPQKRFYRQRAHTNVFVDHSLDYPTSPDDMDWSTHYPAYFSSDPSSSKFEPNHKVEWADVGCGFGGLLMALAPMFPDTLMLGMEIRTAVTAYVADRIAASRQVQETLASDSPDKLPGGYQNVSVIRANSMKHIPNFFAKGQLSKMFFLFPDPHFKVRKQKARIITTTLLSEYAHVLQPGGILYTVTDVKDLHEWMAHHLHAHPLFEYIPTEELAGDAILVAARTSTEEGKKVERNGGDKWIACFRRVEDPPIESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNT1</accession>
    <name>A0A1Y1UNT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_648312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873464.1">
        <property type="nucleotide sequence ID" value="XM_022017821.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UNT1">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNT1"/>
    <dbReference type="GeneID" id="33559630"/>
    <dbReference type="InParanoid" id="A0A1Y1UNT1"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="358"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1694"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1923"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2277"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2414"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2335"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2382"/>
            <end position="2392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2457" mass="270754" checksum="718F241C54917CF3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNU0</accession>
    <name>A0A1Y1UNU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_607564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873037.1">
        <property type="nucleotide sequence ID" value="XM_022014075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNU0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNU0"/>
    <dbReference type="GeneID" id="33555883"/>
    <dbReference type="InParanoid" id="A0A1Y1UNU0"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="253" mass="27597" checksum="87B3C923D80260B5" modified="2017-08-30" version="1">MAPHEGHSVDMDMSGGDMSGMDNTPLNSYSRVCLVPGSSMGNMMMKMYFHGSIGDDYFLFKSWVPTSPGAIVGICIAVFILAIFDRYLAAMRRACDMYWRRGRVGFTVPRSGGTHAYAHPSLQNASNEGNRATGHSSTNGEGCSSTNVDTDQIDSLAADYSGLDEKLDPSTAHLPRAARLVEDPMRTARWSRPFQWGVDIPRGLLQSLQTLIHYVLMLTVMTFQLWFIIAIIVGSGVGEVLFGRFGSGLPGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNV2</accession>
    <name>A0A1Y1UNV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873009.1">
        <property type="nucleotide sequence ID" value="XM_022017960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNV2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNV2"/>
    <dbReference type="GeneID" id="33559769"/>
    <dbReference type="InParanoid" id="A0A1Y1UNV2"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="1">
        <location>
            <begin position="49"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="159" mass="18886" checksum="FB26E11CEF2F4C87" modified="2017-08-30" version="1">MKKDAAYYESNINIRVPNPFLRHRRQLETEKFGEDLRPESKVVSPIARRKQVRLVRKYPALLLPPSVRNPVTPPPIKMDIEGLGVRYIRYGPDWKLFPEIKKGMYAGRAIIFKGHKRERIREVRRQEIAERVAGMDERVRKWREAKAEEKRRSTPAMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNW1</accession>
    <name>A0A1Y1UNW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_577253</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873057.1">
        <property type="nucleotide sequence ID" value="XM_022013246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNW1"/>
    <dbReference type="FunCoup" id="A0A1Y1UNW1">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNW1"/>
    <dbReference type="GeneID" id="33555054"/>
    <dbReference type="InParanoid" id="A0A1Y1UNW1"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="178"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX39194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="404" mass="44897" checksum="FB862108B7977A14" modified="2017-08-30" version="1">MTGAHSRIPTDPSDEALSTSRSRRLMSGYIFGNPPSPDNTTRHAMYSNLVNERHPTPPLRDLQGRDSPPLSEFTAPSSPTTAGEGMDSAAAAASLAKLKMSTEAPGGGDDGLPRTDTYDPLTGLNDGEADLDESAPQAAFTTAEYMKGEDTEAGKYRFPRHRLRKTMKDETKIPLVIVACGSFSPPTYLHLRMFEMAKDEIVESQTFEIMGGYYSPVSSKYKKAGLAAAQDRVRMCELAVEHTSTWLMVDPWEAGQPEYQRTAVVLEHFDEELNARSGGVTMSDGKKRRYKVMLLAGGDLIESFGEPGVWSEPDLHIILGRFGCLIVERAGSDVWAFLLSHDILYSHRRNVIVIKQLIYNDISSTKVRLFVRRGMSIKYLLPNSVIQYIYDNQLYRGSDARLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP40</accession>
    <name>A0A1Y1UP40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CNH domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_614892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873547.1">
        <property type="nucleotide sequence ID" value="XM_022014659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP40"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP40"/>
    <dbReference type="GeneID" id="33556467"/>
    <dbReference type="InParanoid" id="A0A1Y1UP40"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="390"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="633"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="788"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124805" checksum="0AA7A2757C140BB3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ33</accession>
    <name>A0A1Y1UQ33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_260541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873918.1">
        <property type="nucleotide sequence ID" value="XM_022012310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ33"/>
    <dbReference type="GeneID" id="33554118"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ33"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="150" mass="16280" checksum="1E28F81EC211BA98" modified="2017-08-30" version="1">MESVPTLCTDRTRYLSRLPSSHGRVYCALCRDMAILIHVLVLPEIDLQFRVRQEPKNIYKLRDGGQWPVFNLSCMSVVIDLISEKGGREGRGGCRSSAEEAGRPRDAATTAGAVAAALRTVSCCKSPPPSSMKTTDCPDCGKAAAVHRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQE3</accession>
    <name>A0A1Y1UQE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic integral membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874073.1">
        <property type="nucleotide sequence ID" value="XM_022014893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQE3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQE3"/>
    <dbReference type="GeneID" id="33556701"/>
    <dbReference type="InParanoid" id="A0A1Y1UQE3"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="364" mass="39737" checksum="2A89C23DAF307905" modified="2017-08-30" version="1">MPAVSFLPFLHSIPFATRILTLTLVITTLAGIFLTNLIEENTAVGSRIESPHHGLPWRVYLNWLVLVPGTSWKFPWVLVTSGFVELSIVELVMSSVSLLLAARYLERIWGGRELVRFVLVTIFASNVIAFGFSWLTYFVLQDENYSLYGVPYHGMTALQVGFLVAFTQLAPEHQLQLFGQFKVRVKTLPGIYLLISNVLVFLLGPSPYMLVQFGFFVAWVYLRFYKLSEDGLSRGDRSETFAFQYWFPPPVRPYIAKLGNLVFSLATRFKLVPAWDDAQSSSSYAMLPGPGSARAEAERRRALALKALDARLASGPTPAAAAAAGSGGGGATSAPTTSAPSASSTSGPAASTPSIKPDESKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQF5</accession>
    <name>A0A1Y1UQF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_641172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874085.1">
        <property type="nucleotide sequence ID" value="XM_022017402.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UQF5">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQF5"/>
    <dbReference type="GeneID" id="33559211"/>
    <dbReference type="InParanoid" id="A0A1Y1UQF5"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="957"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1376"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1383"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1407"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1562" mass="174409" checksum="1280F2CB19D50217" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR34</accession>
    <name>A0A1Y1UR34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_611083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874192.1">
        <property type="nucleotide sequence ID" value="XM_022014240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR34"/>
    <dbReference type="FunCoup" id="A0A1Y1UR34">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR34"/>
    <dbReference type="GeneID" id="33556048"/>
    <dbReference type="InParanoid" id="A0A1Y1UR34"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002582">
        <property type="entry name" value="Nicotinamide riboside kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="29338" checksum="2C0111CC7E9F03E5" modified="2017-08-30" version="1">MSSERKRIIVIGISGASCSGKTLLAKTLKSILPRATIIHQDDFAPAPEDLPLVDRLQDWDDPPTCIIWDQFRSTLKDIRSGKSPSHESNDHLNVLDAPELDTATIGKWKKAFSDLETEERAHGVQLEWYLVEGFILYWDQAVTNALDIRLFLRVPHETLKRRREGRSVYVIQSASAAGDVWTDPPGYFDKIVYPAYVKGHRHMFEDGDVEQGDVSEEWRNSQHPVKMLVPGEGPEEVMRVVEDSCRYLVDQVKAGAGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URF1</accession>
    <name>A0A1Y1URF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ataxin-3 homolog</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Machado-Joseph disease-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_13012</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 24">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1. Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1. Interacts (via RRDR motif) with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus); the interaction with cdc-48.1 is not required for atx-3 enzymatic activity. Interacts (via C-terminus) with ubxn-5. May interact with ned-8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874330.1">
        <property type="nucleotide sequence ID" value="XM_022011982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URF1"/>
    <dbReference type="STRING" id="4999.A0A1Y1URF1"/>
    <dbReference type="GeneID" id="33553790"/>
    <dbReference type="InParanoid" id="A0A1Y1URF1"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000018">
        <property type="entry name" value="Ataxin-3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="21">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="195"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX40651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="42101" checksum="3757300772A21201" modified="2017-08-30" version="1">MDLVPHMYWERQEPGSQLCAQHCLNNLLQQFTYSEFDLADIAKRLDEAERAQLHEPQSKSHNFDDTGYFSISVLERALEVWDLTLVRWRGEAMREYQEHPEEQVAFILHLSSHWIPLRRFGSNDSYKRWYNLNSFLPHPEWISPTYLRMVLSQAEQEGYSVFCVRKAAPSDDGWGDGGLASLPECQADVFAVQLGEPQGRSGGTVAPIGRGAQMSDQPSVDPSTITPPDEHVDPFDRAGPSQRRRRQPDPVDPFGDAEEDTAPAQRRPAQVWEDEELDEVHDFTQHQRDYDDEDAALQAALRASMEDIPSDWVAPTLQPKTAPKKAEMIHKEPVSAPPQAEEEPEPEGEDETNELEPEELSPGEHRNRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URF6</accession>
    <name>A0A1Y1URF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_611554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874299.1">
        <property type="nucleotide sequence ID" value="XM_022014278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URF6"/>
    <dbReference type="GeneID" id="33556086"/>
    <dbReference type="InParanoid" id="A0A1Y1URF6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013367728" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7940" checksum="AFE92CD31358BE5D" modified="2017-08-30" version="1">MSRTGILGLLTLAKPILSQSTLKGQLSCVCGARHRERNSLRCKADKHLAHVLQRMNVKGLVGSHARFTSRGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URH3</accession>
    <name>A0A1Y1URH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_614864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873540.1">
        <property type="nucleotide sequence ID" value="XM_022014655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URH3"/>
    <dbReference type="FunCoup" id="A0A1Y1URH3">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URH3"/>
    <dbReference type="GeneID" id="33556463"/>
    <dbReference type="InParanoid" id="A0A1Y1URH3"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="224"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="620" mass="68204" checksum="1FBE22E729BCBE30" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URI0</accession>
    <name>A0A1Y1URI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_606505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874329.1">
        <property type="nucleotide sequence ID" value="XM_022014019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URI0"/>
    <dbReference type="STRING" id="4999.A0A1Y1URI0"/>
    <dbReference type="GeneID" id="33555827"/>
    <dbReference type="InParanoid" id="A0A1Y1URI0"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36039" checksum="BD4743E4A825C6E6" modified="2017-08-30" version="1">MSAPPLTFYVEQFTSVPVPPTGALLEGKNVIITGANTGLGFETALAFAKMSPRKLIMTARNMKAGAEALDMVLKGAPGAKVDVWELDLASYASIKSFAARVEKELGTVDLLMNNAGVNLGAVKEAQMTEDGHELGLQTNTFAPILITLSLLDCLRKSTSPRVVFTTSEVHAWTDGKGIAKTAKEGNVIKGLDAISPVAGFPRYMETKLLLQMSVRNLIQALPDITIIAVNPGLCKTSFGRHFGRSWTSPSHWGTMLWMTVIARTGEAGARNLIHAAVGDFESVEYFTCAEPAASPSTFMPKATGLAVIKQYWGELLEEMEKARPGCTKSLQSLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URM2</accession>
    <name>A0A1Y1URM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874042.1">
        <property type="nucleotide sequence ID" value="XM_022014878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URM2"/>
    <dbReference type="GeneID" id="33556686"/>
    <dbReference type="InParanoid" id="A0A1Y1URM2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="54" mass="6347" checksum="3B0B5B87D938C6F0" modified="2017-08-30" version="1">MRAFGTFVSMTRLLAFEGRRRMTMGSIWHERSIPDPYPSQTDPGDRVRRIRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URM9</accession>
    <name>A0A1Y1URM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_575073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874379.1">
        <property type="nucleotide sequence ID" value="XM_022013104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URM9"/>
    <dbReference type="FunCoup" id="A0A1Y1URM9">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URM9"/>
    <dbReference type="GeneID" id="33554912"/>
    <dbReference type="InParanoid" id="A0A1Y1URM9"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="512"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="785"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1070" mass="115984" checksum="9E8C49F0C6887248" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USF6</accession>
    <name>A0A1Y1USF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_612576</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874608.1">
        <property type="nucleotide sequence ID" value="XM_022014406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USF6"/>
    <dbReference type="FunCoup" id="A0A1Y1USF6">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USF6"/>
    <dbReference type="GeneID" id="33556214"/>
    <dbReference type="InParanoid" id="A0A1Y1USF6"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="393"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX40929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="534" mass="57886" checksum="95AC7143D51B2047" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USV5</accession>
    <name>A0A1Y1USV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_37987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874770.1">
        <property type="nucleotide sequence ID" value="XM_022012630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USV5"/>
    <dbReference type="GeneID" id="33554438"/>
    <dbReference type="InParanoid" id="A0A1Y1USV5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="20478" checksum="4C882F3B39D6292E" modified="2017-08-30" version="1">MSRRREAADLARALALSTQESTTQDRREMELLASMDPRTEASIVSGVQQQALIVNQANSSASGPSPILSFSPQVTVPPSSVLAPSSNSGTNSARPPRSSPIYPIPSSRLSTTEKSRSSGSSSHRPIFSPTQTSEERPPGSHRPATPTQNMPSHRPQAGPSRPLREIVLSPSPPAIRQTGHDLSSDHEEEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT64</accession>
    <name>A0A1Y1UT64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874887.1">
        <property type="nucleotide sequence ID" value="XM_022014520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT64"/>
    <dbReference type="FunCoup" id="A0A1Y1UT64">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT64"/>
    <dbReference type="GeneID" id="33556328"/>
    <dbReference type="InParanoid" id="A0A1Y1UT64"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62644" checksum="42F46360D9ABF6CB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5R2</accession>
    <name>A0A1Y1U5R2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_286404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000025">
        <property type="protein sequence ID" value="ORX33332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867681.1">
        <property type="nucleotide sequence ID" value="XM_022012380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5R2"/>
    <dbReference type="GeneID" id="33554188"/>
    <dbReference type="InParanoid" id="A0A1Y1U5R2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="103" mass="11567" checksum="C68E315B220BC3C2" modified="2017-08-30" version="1">MGGLAKYHEPNSRQGAWKRTKLHSLPMLIALQIIDLVLAVPACIPLLERADADPGALNLLQKLRDCTTHRMFSERPQLLQATGFRLASFRSHSQILFRSSSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6A1</accession>
    <name>A0A1Y1U6A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COQ9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_639285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867878.1">
        <property type="nucleotide sequence ID" value="XM_022017214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6A1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6A1"/>
    <dbReference type="GeneID" id="33559023"/>
    <dbReference type="InParanoid" id="A0A1Y1U6A1"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36095" checksum="5F6C0424BCBD3BCD" modified="2017-08-30" version="1">MSLKTTILQYALPLLPKYSFTRDTLSLALQQIRSVEQPLAPSRAVSRDFAHTSQLDSIGRENIIDTLFGTGTTSPAKALVESWQVEGLKSVDSGHDRASLTERLERRLEYSSGVGEHLVEAYALLSAPGSTPSVPVPRSVLDHLPRFDFPPLYQPPGTASTSSHARLDPPATSRVGAASEWDSITLLDKLESLTGGRIPFLRFNPLGPLGYAWDIADHALRIDETRSGQTRGMMNEPTGAGPEWYTSRMSIALAYLAAESQLLQPQASHPVAIEDAAHHLSAAKRALRTHLKRYDGAREIVQSSESGLKDVGSMLEFFGRGMIGLLRSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6L2</accession>
    <name>A0A1Y1U6L2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867981.1">
        <property type="nucleotide sequence ID" value="XM_022017191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6L2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6L2"/>
    <dbReference type="GeneID" id="33559000"/>
    <dbReference type="InParanoid" id="A0A1Y1U6L2"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="379" mass="41928" checksum="CD05F02FBD0783FC" modified="2017-08-30" version="1">MVSTRSRKSSGTEESGDKRSAPQESTPKSKKPKTEHDGKLKVSEGEIGLSKQEDDDEEDQSKTEDEKETGEEKEASNENKEESKPSRDEPHLSGILEEPKHGTLESGHIYFLYRPKVDAEEVDSVDDISKFHILLIPTSHPYGKSHYHRIIEVGKKKLPDPHASRQVIWGLVGNVGSDKAELKNAFGAYDYETKTKGTRHQSAARPAARGHYILHSPRDELADSPDHDRQRDFKILLAYEITTPASEDFGQVQSDLGIAEKGAVALQVKSPEAESTNPRAASIPKDKRASYPKKLDGLFANRRFIPANPPSFLDYSGGELLLLSSAHDLAEWLGKDGKKIVHDLDNDASKEQVGIDGAMKELGMSKKDTEIEALEGVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Y8</accession>
    <name>A0A1Y1U6Y8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_654271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867625.1">
        <property type="nucleotide sequence ID" value="XM_022018781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Y8"/>
    <dbReference type="GeneID" id="33560590"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Y8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="674" mass="77052" checksum="D628FB95E6EC4A3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U707</accession>
    <name>A0A1Y1U707_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hexose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_638715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868118.1">
        <property type="nucleotide sequence ID" value="XM_022017150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U707"/>
    <dbReference type="STRING" id="4999.A0A1Y1U707"/>
    <dbReference type="GeneID" id="33558959"/>
    <dbReference type="InParanoid" id="A0A1Y1U707"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="123"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="621" mass="70142" checksum="438E2C1DF627ABB7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U728</accession>
    <name>A0A1Y1U728_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_610678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000024">
        <property type="protein sequence ID" value="ORX33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867691.1">
        <property type="nucleotide sequence ID" value="XM_022014210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U728"/>
    <dbReference type="GeneID" id="33556018"/>
    <dbReference type="InParanoid" id="A0A1Y1U728"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013095918" evidence="2">
        <location>
            <begin position="24"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="574" mass="62940" checksum="EF4434A647221BFD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7C4</accession>
    <name>A0A1Y1U7C4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor Pcc1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_637734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868218.1">
        <property type="nucleotide sequence ID" value="XM_022017040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7C4"/>
    <dbReference type="FunCoup" id="A0A1Y1U7C4">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7C4"/>
    <dbReference type="GeneID" id="33558849"/>
    <dbReference type="InParanoid" id="A0A1Y1U7C4"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="142" mass="15722" checksum="6248207DBAB805C1" modified="2017-08-30" version="1">MESEHADASSNQAGPSREGWHTVSMRIPFLNHQHATIAKRALEVDKEQHPGLIHRTIEVENEAVVVHYACATVRLLRLSTNSFFSSVDLVVRTLEAFAPDPDRPDPTDEELEEQRRLANSAQTKGIELRGDGKGAGSGEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7G8</accession>
    <name>A0A1Y1U7G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867811.1">
        <property type="nucleotide sequence ID" value="XM_022013716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7G8"/>
    <dbReference type="FunCoup" id="A0A1Y1U7G8">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7G8"/>
    <dbReference type="GeneID" id="33555524"/>
    <dbReference type="InParanoid" id="A0A1Y1U7G8"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="279"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="520" mass="56734" checksum="130D255A7402BBF7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7J6</accession>
    <name>A0A1Y1U7J6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_274629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867804.1">
        <property type="nucleotide sequence ID" value="XM_022012351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7J6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7J6"/>
    <dbReference type="GeneID" id="33554159"/>
    <dbReference type="InParanoid" id="A0A1Y1U7J6"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="24086" checksum="54AE9E33E8DD8C23" modified="2017-08-30" version="1">MTGSMAYSSFPPSASIDRYDAYDVGDITLQSTTSNIDDEVYRYSAEFDRQQYFESMLKSPSGFAGLGVSIPGIPRSGLYAQDGLWDEDDGISDSTTLRPVSGSTVGTGQTARHSSKASPSTMNASASTKSRDRSGTASSAVQPITLESRESKSWSWNRKSATPATPIISEVPSSPAISQTPESKRGRVHSLKSQRSKSRLRGKGRKGELSVDVGNDPDESVSNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8A9</accession>
    <name>A0A1Y1U8A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_637242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868526.1">
        <property type="nucleotide sequence ID" value="XM_022016982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8A9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8A9">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8A9"/>
    <dbReference type="GeneID" id="33558791"/>
    <dbReference type="InParanoid" id="A0A1Y1U8A9"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="570" mass="63959" checksum="C225DE04AA7A9F19" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8H4</accession>
    <name>A0A1Y1U8H4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_142015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868604.1">
        <property type="nucleotide sequence ID" value="XM_022012011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8H4"/>
    <dbReference type="GeneID" id="33553819"/>
    <dbReference type="InParanoid" id="A0A1Y1U8H4"/>
    <dbReference type="OrthoDB" id="2590746at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="480" mass="51026" checksum="5AA6DF9889F2DFDC" modified="2017-08-30" version="1">MKRSVDILGVGTVEPTEIWSPVPREGLQRPLSATGGLHSDIDSSGSAQIATLQKRSPAAEHQGEAERGSVTASGSLRQSLDSASLSIDTRRQERTSRNFLGRIFKKRGGDQEVVTSPGVDSKNCKAEDISSNRSAKKRAPRSLSPNPAVMIQPTLSDASKDESVHLPVSIGQPTFGTTPSIQSADRACAIVTESGAVGGLTSLALPPPIDSRAPNGKNVGGTQYFSLCQSSRPVGYSWKISKWSKKRLEKWIRQLGGSGGNTLLQTAEGGVVFEWVKLRMPQDALNGALSRKLAQAGAQPTVVIGNQPGSNRKTPTAPLTPSFSLDAETREAASVSPSEVEDDAGSHTSRSNSHVGSASIDQPDGSLSDHTIDSGDESEPEDSETPWTCSVWIKRTGLRIPLATLTPAPHHPKVIGVLKIPTELDLVRLGFGADAVERRSLEAIGLSEENVKDVVCVTAMWLVAREEFGGLGKKRRGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8K9</accession>
    <name>A0A1Y1U8K9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868135.1">
        <property type="nucleotide sequence ID" value="XM_022017157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8K9"/>
    <dbReference type="GeneID" id="33558966"/>
    <dbReference type="InParanoid" id="A0A1Y1U8K9"/>
    <dbReference type="OrthoDB" id="2569556at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="244" mass="27646" checksum="0D64DF4185200655" modified="2017-08-30" version="1">MSSAITMRSVAGPSRLAFTAPLRHLSTGPRSTGSNEPKPPASPPAWKPKRHGGRQHAPDHTAINSKRARRDVLARLVSLHHTAASFMHQAKDISTGFDNAFRYIEAEPYFLPFSRWKRGVLEHIADGPKVKERPVREDLPPLGRELEQRETLQPAFSHWRTFQPIESSWIHSKREIKGLAKSEREKQVKEAFFGVWDRGGVGMEDSQPSLEGIEEWIEARGSTVKEVADEWRANRTKHVAVVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9H9</accession>
    <name>A0A1Y1U9H9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_634498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868931.1">
        <property type="nucleotide sequence ID" value="XM_022016736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9H9"/>
    <dbReference type="GeneID" id="33558545"/>
    <dbReference type="InParanoid" id="A0A1Y1U9H9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="485" mass="55289" checksum="4F0CC821DD4B2D27" modified="2017-08-30" version="1">MSSSSFMVLRASSSRRSISSLVHIDAGGRRPSHRPKDRFQIEPVPTSITCSRSFTSSAFRHASTTTESAGSKGTTKQSAFQERMAKQEMTMQQFSQKKRIQAELHRRHAGLSFPLFNDLTYAPLTLDMILKGLTTPGNLWRHLRHRWMRDDITMNMATQAEGATINALKPDYVPRVLNPYQKVKHWLMKRGATDAPEIAYKPQMRYASYLARAFDQWKIYNEALASRDTALLDQVAVNPAIKLGHVLMSSNRIVDWQVTKEFAKPELLWMRLASEDERGVSAYFQVCVRFDTEQVSQTTIIHDISCRARQTITTVETSARPELPVAPTAAPGKRVPDWKLREYRDAMLKYQYQLATDLHHRQQGDMVFPEGVGIKSLKSVQGLPRHTETSRVIDNVVFQFTTAEASGPWKVRERVPSYPPHYMMTEEAWEELQRKSLETDEKMGVPSTLTIHHVNTSEWNKRQRLEAEQGSPSDDQAKRIGAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9K1</accession>
    <name>A0A1Y1U9K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_634585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868951.1">
        <property type="nucleotide sequence ID" value="XM_022016746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9K1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9K1"/>
    <dbReference type="GeneID" id="33558555"/>
    <dbReference type="InParanoid" id="A0A1Y1U9K1"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="922"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="950"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1245" mass="134556" checksum="5F1E9498E61C3F09" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9N4</accession>
    <name>A0A1Y1U9N4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_582961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868985.1">
        <property type="nucleotide sequence ID" value="XM_022013588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9N4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9N4"/>
    <dbReference type="GeneID" id="33555396"/>
    <dbReference type="InParanoid" id="A0A1Y1U9N4"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="307" mass="33345" checksum="FCC81B30E0D92567" modified="2017-08-30" version="1">MSTAPTSLLQTALQNLHVSQQARDQSHTPLADDASEATASSSRNVSPPESGTDDDLDDGDDYIAVGRGTRPGTPSVSQRGFKSKKKDPLRTLPTHLAVRVFLELDVKALARCDAVCKRWHKSSTLNYVWFLQNRALTLPSLNSISGPGGKLKQAVDDTPEYFDPYDKTPRLAALPKPPLPQSNTPQWTKNESKKVWKTAFHLTLKRSDPNAELEDDPLHVDISSLHTSGTNTPSRHSHAGQGSGGAAKWVSMASNGPMSPSERKLAARENYKALGGRKSRAKRKMGGEMGARDKGGAVDDGRFDAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9U0</accession>
    <name>A0A1Y1U9U0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_134822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869042.1">
        <property type="nucleotide sequence ID" value="XM_022012003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9U0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9U0"/>
    <dbReference type="GeneID" id="33553811"/>
    <dbReference type="InParanoid" id="A0A1Y1U9U0"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="441" mass="48675" checksum="9E7DD6C7742606B8" modified="2017-08-30" version="1">MQVRIIEPTSDCTSEPYKAVQFVTSVPICSFQTITMAICTALRVPEPAVKGVRGSRHSDDMDLKAASAQTSTRKRPEVYPNTDRPNVAQIRQYFKTAHEDDDTIFVSAHRGFTERGVVENTFPAILKAAGMGAMSVEIDIRLTADGVPVCLHDDGLGRVTNIGEVHGRKDIYDPLTGQGYNPLASSIPWHGAAEHLRLKDHLGDLTSVPIMTLESMVRDIIDSGIQVMVLLDIKLKDVMEPAYEVIRRFVDRNGQSALAWCIFKPDITFCPTPQSLREEQWLGRAAARGDVITWIPVFDIASPVPAGLQMLDLVKLWAAEPNTLALELGLRHKGGPLQEVVDWAIEGGTDLRLGFYGAFGDEWLEKDPRCPESSAPLVVWEDHPPTSFDGILQSKGISGGDRRGDLELFWGLGFSWIISDHVKQSAKLVVEQSRLGDRIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9W1</accession>
    <name>A0A1Y1U9W1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869073.1">
        <property type="nucleotide sequence ID" value="XM_022018606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9W1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9W1"/>
    <dbReference type="GeneID" id="33560415"/>
    <dbReference type="InParanoid" id="A0A1Y1U9W1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="699" mass="71028" checksum="18D3DA3A07A4D392" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA67</accession>
    <name>A0A1Y1UA67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_633312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869157.1">
        <property type="nucleotide sequence ID" value="XM_022016614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA67"/>
    <dbReference type="GeneID" id="33558423"/>
    <dbReference type="InParanoid" id="A0A1Y1UA67"/>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="205" mass="22743" checksum="20405C3F7986B6D0" modified="2017-08-30" version="1">MMSRRSMAHTKETSEHPRPGGARRRFRIIASTGSWCCTSHKSYRDQIHTSSLPSPSSSKKMSGTPPPPENKMKHFKAINALPSQYPDFRTVLWTGRDSQLVVMTVPVGGDIGEEVHEVDQHLIFTSGKCKAIVAGEEAEVQAGDMVVVPQGTKHNFINTGPTPLCLFTVYAPAEHDPRSVHKTKEEGDKLEDDGKDEPPKWAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA96</accession>
    <name>A0A1Y1UA96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_609700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869165.1">
        <property type="nucleotide sequence ID" value="XM_022014167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA96"/>
    <dbReference type="FunCoup" id="A0A1Y1UA96">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA96"/>
    <dbReference type="GeneID" id="33555975"/>
    <dbReference type="InParanoid" id="A0A1Y1UA96"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118727" evidence="3">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="341" mass="37650" checksum="9932575964594428" modified="2017-08-30" version="1">MSSGLNILLLRPQLLLASLHDLVLLTALRLIDPSHVPIASTLSFDDAAPLEEVETSQIAMDRLAQSLRVNQEVMDKIRGMESKLAYQIKKLSGLAEAEEARGKQVIEDVEEDPLAFRPNINAMVLSNGDSHASSSRKQRSTNDNVDDDDKEDKIYRPPRVAAMPYNEPGKAARKDRRAPALLSEFADTMDGAPILESTSGLATRPVRLDRHTNSLSAKRAKELKEIKEYEEANMTRLSTTKREAKRRREDEEALALGHGISEKARGRRGKVNGLEAELEGVLGSRGSRGVWDGVKDFGKRGDAVERGRKAGGIVDIGPSSSRKKKKARFEKDLAGHKKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAA4</accession>
    <name>A0A1Y1UAA4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868710.1">
        <property type="nucleotide sequence ID" value="XM_022018633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAA4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAA4"/>
    <dbReference type="GeneID" id="33560442"/>
    <dbReference type="InParanoid" id="A0A1Y1UAA4"/>
    <dbReference type="OrthoDB" id="3250803at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="49557" checksum="D8949776CC89B490" modified="2017-08-30" version="1">MSSSAHGLLSFLGLDDDNDRRDQPFDSNSSTSPDNSPSSAPADGVGAIVSSVVPTTQPQPTTDPATTSAAPTQDLTTAPTTSPSPTPSPEPTTQTPASEPATISKATPTQDSKPTTSPPPESQQQTTQESASPAPETSTQQQQQQQQQTQPQSTQTSTQAAASDANEASPNPTTSVAATSSSATSAPAANNAPTTISVATTGRVQTQTSTDANGRVWTVTVPVRNGATDGASTESDDTTSGFFGNTGAVAGVFVVLGLLVAGVALAIAIILYRRKRSQRLDREVDFVASNRSHRDDDEKSTGARSTFMDGPYIGDLHQAPAQSAGTYAFDDPSGGYDSYALNLPSQNALGGGDRMSTVTNAGMAGFGAQSAAAAYNTTYPAQPEPTLNYAASGEGYEELNSPVDGTFRSGSRTGYAVTTDSQPPANQGYYFDPRQADEFHEDQDEILQYPQRAHRPDSSGSVVRDLVNDRGLTVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAB8</accession>
    <name>A0A1Y1UAB8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868757.1">
        <property type="nucleotide sequence ID" value="XM_022016871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAB8"/>
    <dbReference type="GeneID" id="33558680"/>
    <dbReference type="InParanoid" id="A0A1Y1UAB8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="155" mass="17336" checksum="EE8F6AD18690CB7A" modified="2017-08-30" version="1">MTSCPVEQEGSHGRIYCSDGLVGLTKWYQSSNAMTQRHHLEAATCPESENRTCFTYIDTYSSAVLDSEKRCLNCLRLSDASNARTEDQSDGQTYFWWYPPGRTAAEGSAERNNNVFKTGQEKTFHTSGYATEPKSSPEESKESHDLKVSKEMPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAC4</accession>
    <name>A0A1Y1UAC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_636042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868730.1">
        <property type="nucleotide sequence ID" value="XM_022016859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAC4"/>
    <dbReference type="GeneID" id="33558668"/>
    <dbReference type="InParanoid" id="A0A1Y1UAC4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="216" mass="23837" checksum="1E0C044789B576DA" modified="2017-08-30" version="1" fragment="single">MHDSSPSLQEALLQHRIPLSVELASTYGVKHSCHGIPYLVLPEPHDSFCLTNFLLPPCDAGLSSSATSGHFRENDAEAYARILNTPEAAEGLATPKYRVITVDERREWLKQILARAPSGWCMSGKWVLASLALIVVIRRTEDVESSPDPMMIGTIGVKRLVFQLLSPEENAMWTERERDLPDDQVHWSIGATLDPAFGGQGLARVGLCRSLHVILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAD7</accession>
    <name>A0A1Y1UAD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_603832</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869214.1">
        <property type="nucleotide sequence ID" value="XM_022013964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAD7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAD7"/>
    <dbReference type="GeneID" id="33555772"/>
    <dbReference type="InParanoid" id="A0A1Y1UAD7"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="215"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1204"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1261" mass="138171" checksum="4BCCAADB717C3128" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAN6</accession>
    <name>A0A1Y1UAN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_633866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869305.1">
        <property type="nucleotide sequence ID" value="XM_022016670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAN6"/>
    <dbReference type="GeneID" id="33558479"/>
    <dbReference type="InParanoid" id="A0A1Y1UAN6"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="6">
        <location>
            <begin position="45"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="250" mass="28587" checksum="7FAAAB4463AE9560" modified="2017-08-30" version="1" fragment="single">MAPIACSRYVVAAACLEYLAQQSLPRILRNTKAGTDRDILLLTNRIVGGLHSLLIGFAAWRETSKDHWKQDDLIKTNSELGNVIIALELGFLLQDTLFLIQHRKAWSNRSSLRRILLHHLAYGFLSAWWLRAIEKKYSKGGAYFVISFLMMNLSNPPRYIMWCVRKYMQGSDIKQQLLTLTHLVSLLIYAWTRLGVPFRLIHVYGQRKGLSTYEAFSSLPFVCRSTTSVIALVSLSQLLQLSSRWPRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBM2</accession>
    <name>A0A1Y1UBM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_94682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869582.1">
        <property type="nucleotide sequence ID" value="XM_022019288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBM2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBM2"/>
    <dbReference type="GeneID" id="33561097"/>
    <dbReference type="InParanoid" id="A0A1Y1UBM2"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="822" mass="91675" checksum="1EF45346E032B9C6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBV9</accession>
    <name>A0A1Y1UBV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_582657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869182.1">
        <property type="nucleotide sequence ID" value="XM_022013571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBV9"/>
    <dbReference type="FunCoup" id="A0A1Y1UBV9">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBV9"/>
    <dbReference type="GeneID" id="33555379"/>
    <dbReference type="InParanoid" id="A0A1Y1UBV9"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440532" description="Mannosyltransferase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="625" mass="70434" checksum="A13A4030FFF18CCE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBZ5</accession>
    <name>A0A1Y1UBZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_630568</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869703.1">
        <property type="nucleotide sequence ID" value="XM_022016340.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBZ5"/>
    <dbReference type="GeneID" id="33558149"/>
    <dbReference type="InParanoid" id="A0A1Y1UBZ5"/>
    <dbReference type="OrthoDB" id="2563870at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="939"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="233"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="610"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="903"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1463" mass="161832" checksum="317F4EAA6D390210" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC68</accession>
    <name>A0A1Y1UC68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_643243</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868917.1">
        <property type="nucleotide sequence ID" value="XM_022017532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC68"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC68"/>
    <dbReference type="GeneID" id="33559341"/>
    <dbReference type="InParanoid" id="A0A1Y1UC68"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="49"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="407"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="618"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="674"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="921" mass="99720" checksum="45616C11C604ECC4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC97</accession>
    <name>A0A1Y1UC97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869373.1">
        <property type="nucleotide sequence ID" value="XM_022018568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC97"/>
    <dbReference type="GeneID" id="33560377"/>
    <dbReference type="InParanoid" id="A0A1Y1UC97"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="280" mass="28928" checksum="FEA9C95167BAB50A" modified="2017-08-30" version="1">MGPLSAVSTAASAVSNAAKWTANSTANALTLGWWNSGTQADAGSATDKDTATGEVTDSKGATEADTKVSDSEADKPIRYVEKTRALYDPWAWMPSVLGGTSTYIEREDPLPQGVLGRTIGYATAPIGTLASVVSRPLTYATKSILGTERYTKYGKYVNGGVNVKHYIQTTGGQLTEVGHERGNAERLAAEVADTKPEGTTSERSPSHSSAGGTIPETTKTSAAARDTAGTSLSQPTAKDPLKDKKIAQILEKFQASIAAHGTPGSTTDAPPAPSAVAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC2</accession>
    <name>A0A1Y1UCC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_631255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869862.1">
        <property type="nucleotide sequence ID" value="XM_022016417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCC2"/>
    <dbReference type="GeneID" id="33558226"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC2"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="153"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="686" mass="74443" checksum="1B2AFDCF1345E435" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCD8</accession>
    <name>A0A1Y1UCD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_631111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869843.1">
        <property type="nucleotide sequence ID" value="XM_022016407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCD8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCD8"/>
    <dbReference type="GeneID" id="33558216"/>
    <dbReference type="InParanoid" id="A0A1Y1UCD8"/>
    <dbReference type="OrthoDB" id="2564297at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="909" mass="94707" checksum="16C35016FB7BF01E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCK8</accession>
    <name>A0A1Y1UCK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_79816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869952.1">
        <property type="nucleotide sequence ID" value="XM_022019249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCK8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCK8"/>
    <dbReference type="GeneID" id="33561058"/>
    <dbReference type="InParanoid" id="A0A1Y1UCK8"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43159" checksum="EE4793E5AA625E21" modified="2017-08-30" version="1">MDDAIGSSSKTTLDMLAEIGVGTAQQLVTSVRYANAPPGLTFIPPLDDILLCARPHPGGSSLQRGDLIELIGPSGAGKTTLLSFVLTTTLLPSHIDIPLPAPGSHVVRVPLGGAGSHAFLLQPTSHAPMTKAIRVKMFSHIQDCILDTLSINLRPRVLTPALKTIIQGAIHDALSRLHIIRFTPRWKQLYLALSRVLHPPELKIGTSSQMDKVRKQTVSTLVIDGFGDPFWPERWAEEDKRLKRSTMPVANGDGVGLKEIMRIIQTLRVHMGTVVYLSVQSLWGKPTSPFFVPHLPAPYPHTFSVPRESVDERHHDTSINIQLTLLGRVRPLQLPADLTLVNALREATAKDWTMAQHFEGIARVHGGEGAAGSLAGQKFSFKIGSLGVEVWSGPQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCM0</accession>
    <name>A0A1Y1UCM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_581799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869916.1">
        <property type="nucleotide sequence ID" value="XM_022013525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCM0"/>
    <dbReference type="GeneID" id="33555333"/>
    <dbReference type="InParanoid" id="A0A1Y1UCM0"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="474" mass="52659" checksum="22F6C184850AACBE" modified="2017-08-30" version="1">MAAGTTPTAKAKANGSKKSAGSPAKSKSKASAGKSPKTKAKAKAISSADGKPKPVRRPEIIPDLPPFEKVDTRLDLTEAEQRMALREYLFRFRAALSIPERSLPPVDDFDRPLTEASVRVFAGSMLELIREEIEHNGQLADKILHHREELRYYADLARFAAIYMGLEDSLGLRKPIGQERDGSLPVELDLSSRRSAASRLPSPIRVVQMLLALSERTLRTPAIRADLESQTEENVLRRQHLSAVKKETAAWETRKKKLDEASAKTKGAADSKAARANLASELREHQLRVVQLNVNLRADLSRRALRHESLGSDRDGRTYFVLSMRPVTHDGRPPIAWASGLLVWGKGDPGSQASDAVPSDMERWSHFGKSQSVKQLAKWVEWSWKKTIASVKTKNTKAGRAKLEVVIPSHKRARSSSSSALSVLSDNLLDDFEPQGYEPSPDMLDARAKDLVRRLHEVAEWLEVLEWKGMGEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDE7</accession>
    <name>A0A1Y1UDE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_592224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870190.1">
        <property type="nucleotide sequence ID" value="XM_022013812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDE7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDE7"/>
    <dbReference type="GeneID" id="33555620"/>
    <dbReference type="InParanoid" id="A0A1Y1UDE7"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012508231" evidence="9">
        <location>
            <begin position="25"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="428" mass="45107" checksum="E26FDC2A03478F9E" modified="2017-08-30" version="1">MSSTVGRVFAFAWAVSHALQYGLAITGLNGISDAVTCADKPAGYIPTKGWVTPCVPMDSTRFGFVVSIFTVGGLIGSLSSDYVARKTGRIGTFRVAAFAILIGSVAVGLGASVPAMLFGRVVIGLGCGIATATVPVFLAEIAPPSIRQALGITNQLFIVVGLLTGQALSLPLAKETIWRWVFAVSFFLAIAQLIGSLFVKTPGSSDGEEEQPLLPSEEPMSIRELLTSQDPVIRRGLVVVIITQLAQQACGISPVMYFSTRILKPVFSANSRMVALAVVAWKIPLTILPAFVIERAGSKPILLVSSGFMAISALLLAIGLNANSGPLSATSIVSFVSFFSIGLGPVVWVVLSQVMPPQARTAAGAIGIALNWTANGLISSAFLPLQQWLSRDGKYEGNIFYIFAVSCTVVFIAIRQSYAAFNRAKTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDH6</accession>
    <name>A0A1Y1UDH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_630030</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870191.1">
        <property type="nucleotide sequence ID" value="XM_022016283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDH6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDH6"/>
    <dbReference type="GeneID" id="33558092"/>
    <dbReference type="InParanoid" id="A0A1Y1UDH6"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012033510" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX36062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="52111" checksum="456A8EFEF6505B38" modified="2017-08-30" version="1">MLNAIVFLIILRAAPVLSSWIPSASNIFVEVATWLEPTNNLLAITEVNGPEGRTRRCRLMASGVDDTDGLELAVAKCGSRGIIDLPHPRYIISRPLDLRLEHSTLNVHGFLTFTDDLDYWKSNHIAFPFQNQSLGLVFHGHHFTLDGHNTGGIDGQGQKWYDDARREGNKYGRPMSLAISHSHDVVIKNWSIIQPQFWASLVAWSRNVLLKNVYVNATSYNPESWEEPDGKSWLQNTDGLDTYNADNVTVENFVYQGGDDCLALKANSTAITFRNITCVGGTGIAIGSLAQYPGVTDIIEDVWIEDVKLLPAPSNQCALFQGLLLKAWGAETHGTPPNGGGGGLGYAHNITFKDIYMEGIIRPIVLQSTLTYLSNVTLSPGNFEWSDLHFRNITAMSKYNRLIWLDCPAQHPCRNFTFRDMHLIPGATDHPELRYVCNNVVLGGKDGLNECHPSDSMLERREDGWPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDP2</accession>
    <name>A0A1Y1UDP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_631088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869831.1">
        <property type="nucleotide sequence ID" value="XM_022016402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDP2"/>
    <dbReference type="GeneID" id="33558211"/>
    <dbReference type="InParanoid" id="A0A1Y1UDP2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="38772" checksum="1848863A0DD48B15" modified="2017-08-30" version="1">MNANKGSPSNSHSVTSKILFNVSLQYISLLNTSLIREPHRRVLMSASSINTTEHGSSVVPPSGRWRLLHIGVADLLIAKRLTVLVTSDVRGDTKRLIAKFSGTGKGKSELYLASQGFKSEKFKSFGKDYPFSRLLQTVDKFRDIAQAQNVQPGYSFLDAAGNISTLIDPRTWLFCPLDSDQNPYTITFSEVTRNEAARLQSGPPTERDTGVSAVTHLSPASAQQRTNDEAVSVHDQVSEPTDTISEPADEPGGKDSDYLDDGPGEDDDDFLEDSDGLSSDEASGEAEDEDKEDLKRSRRLTRTAQGKRKRSLVSSPTDSESSLPSGHDVIVRGSRGDTDHSDSELSDPPESPYNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDR9</accession>
    <name>A0A1Y1UDR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_68025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869828.1">
        <property type="nucleotide sequence ID" value="XM_022019073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDR9"/>
    <dbReference type="GeneID" id="33560882"/>
    <dbReference type="InParanoid" id="A0A1Y1UDR9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="142" mass="15051" checksum="6BAB7D64435B1567" modified="2017-08-30" version="1">MVSHALGTILTWTRWSHHFLGDVSSQGARRFGRIRNGTGTFPAFSHLPSLPSLFASFHTLRHYKRTTMAQSPAHEGTDPIGKGSVSQTDGPKQLSDAQQRPGGQEGGVSGTAVQNAKNAAASLGEQAPGTDSAQGRKDIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE12</accession>
    <name>A0A1Y1UE12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_580652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870382.1">
        <property type="nucleotide sequence ID" value="XM_022013450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE12"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE12"/>
    <dbReference type="GeneID" id="33555258"/>
    <dbReference type="InParanoid" id="A0A1Y1UE12"/>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000702">
        <property type="term" value="F:oxidized base lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47203:SF1">
        <property type="entry name" value="HYPOTHETICAL BASE EXCISION DNA REPAIR PROTEIN (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00730">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="2">
        <location>
            <begin position="137"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="347" mass="38452" checksum="B4334FB02C963FAB" modified="2017-08-30" version="1">MVRASTRSISKRTAVNASPSSPVLGKRSAPSSPIPKSIKDEPDTVKDEPLTSVKDETVSPSKDTLASRKRHKHTKSIELEPFPTFHRPLPDECALAHRILSSLHGARKRPANIVAPTNRAGCGDSPSVLDALVRTILSQNTSDSNSSRAMMSMNEAYGGALKWKEIVEGGQPKLQEAIKCGGLSVVKSKVIIKILEQVYEKYGHYSLDHLHKASTEDAMEELLSFDGVGPKTASCVLLFCLCRDDFAVDTHVFRITKLLGWTPAKANREQTYHHLNRRIPDEHKYGLHILIVTHGKRCDECKAGGRAAGKCELRKAFRDQAPKGLKQEIKEEMEDEDDVKDQVKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE92</accession>
    <name>A0A1Y1UE92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_676275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870472.1">
        <property type="nucleotide sequence ID" value="XM_022018955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE92"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE92"/>
    <dbReference type="GeneID" id="33560764"/>
    <dbReference type="InParanoid" id="A0A1Y1UE92"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="293"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
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        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="735" mass="80858" checksum="49D3FCC6599012D5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEE5</accession>
    <name>A0A1Y1UEE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_491031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012933.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1UEE5">
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    </dbReference>
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    <dbReference type="GeneID" id="33554741"/>
    <dbReference type="InParanoid" id="A0A1Y1UEE5"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="342"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="744" mass="82561" checksum="239F8C72F8078552" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEM3</accession>
    <name>A0A1Y1UEM3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_499443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870579.1">
        <property type="nucleotide sequence ID" value="XM_022012949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEM3"/>
    <dbReference type="FunCoup" id="A0A1Y1UEM3">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEM3"/>
    <dbReference type="GeneID" id="33554757"/>
    <dbReference type="InParanoid" id="A0A1Y1UEM3"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="485" mass="52998" checksum="DE6472F40D45842D" modified="2017-08-30" version="1">MQRSMTTQATEVAGMIIILPIDLGVLLSCHFRPLCHCFYLHSTFLEKKKSKTRVQDALYRTLDEFCGKAWTYGSMFKFNFELDEAEVDNEFGGTASSFLDGCPINVEAGPSRPRAVMPCHTVSLDQLLDRLPDKISYSPIAIPGSRSLLRRDLFDARFQLASEHNTAPHSDPVNGASTESDLPPEAGGENQGEGVIDVHSDLIPGFYEGGLKTWEGGVDLVEVLSEVKDIADWIRGSSILEVGCGTSLPTSFLLGRILSTPGSSSSRTTFRLQDYNLSVLSLVTLPNLLLAALPHIPPDSLLPAEQVEDVEQVLPDLDASGELVISPELKQGFKMLLQKCHVDLLFDYGAWSGLVENLKSAPQQRFDLILTSETIYSEDSVDDLMDVLRIGSTGTASREEHGDKQHTAVELADSIADLSVRDRWDLLPLREQSSAVILVGAKVLYFGVGGGLQAFLDAVKANGGWYETIKGWTAGVGRKVVRVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEY1</accession>
    <name>A0A1Y1UEY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870672.1">
        <property type="nucleotide sequence ID" value="XM_022018263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEY1"/>
    <dbReference type="GeneID" id="33560072"/>
    <dbReference type="InParanoid" id="A0A1Y1UEY1"/>
    <dbReference type="OrthoDB" id="2563576at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11950" checksum="7A6484A9B400E74D" modified="2017-08-30" version="1">MAIKRSSSASFDDNDDHITHSSPDYNPSDDDAPKRKKTKTSSESPKGKTVIRKWTPQEDAIFIELAMQLLKTDMWKVIKEDGRLAYRGSPGITAHVKAMVKKMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF02</accession>
    <name>A0A1Y1UF02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870720.1">
        <property type="nucleotide sequence ID" value="XM_022018275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF02"/>
    <dbReference type="GeneID" id="33560084"/>
    <dbReference type="InParanoid" id="A0A1Y1UF02"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="273" mass="30529" checksum="A2BA694A2F49AFEA" modified="2017-08-30" version="1">MSSYPSFAKAKEAAIKVVDEEYDHYLSIWTHDEKLGDDVDVQSTDHEEPVPFFIKLEFDEDETVRLWVEPRDANGRSVIPESSWTVRPERERYMARQAREDLKKTKAAATKAAKANKDGKVLSDELRPSDKVYIILSADGYVRQAGNLPRNLVYKSLRYANMQARSLLYQSTIDSSKDAPLPAILPAFAEEEFNVDSSTATYVGRVKGKGKKVKSIWVEEMSFDSYVPPPPEGSVTKGKKKATGTSGQKRATPSSGSRVSTDTAKRGRRRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFH9</accession>
    <name>A0A1Y1UFH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_601954</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870365.1">
        <property type="nucleotide sequence ID" value="XM_022013937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFH9"/>
    <dbReference type="FunCoup" id="A0A1Y1UFH9">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFH9"/>
    <dbReference type="GeneID" id="33555745"/>
    <dbReference type="InParanoid" id="A0A1Y1UFH9"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="305"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="425"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="522"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX36264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="617" mass="68248" checksum="8FBC63C0080D8D7E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFK7</accession>
    <name>A0A1Y1UFK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_608851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870910.1">
        <property type="nucleotide sequence ID" value="XM_022014125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFK7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFK7"/>
    <dbReference type="GeneID" id="33555933"/>
    <dbReference type="InParanoid" id="A0A1Y1UFK7"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="285" mass="32905" checksum="9254CC5D99812B7B" modified="2017-08-30" version="1">MPESSKEMPSKGKGKGKIAVDMDDVLCQTNGTIVEMHNEIWKTEPPLELADFKNYLYWQNRGWSSPTETVKMVARLFDEGLCHRAQPIPGVKEGLLRLKQMGYSLIIVTARGERERKWTEDWIATHLPDIFDEIHFTGAFAHVYTTAQEKEGHVAKKAVMSHHKRSKADVVHETEALFLIDDSAENALDASRSKTPCQVLLFGDWPWNRIIRDPDDRLPEDVILYVDAKDKGLLDRVESRRQELIERNWIPHGVERVSNWEQVIEWVEDWEKDGCPPLPRQRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFU2</accession>
    <name>A0A1Y1UFU2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_628638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870485.1">
        <property type="nucleotide sequence ID" value="XM_022016131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFU2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFU2"/>
    <dbReference type="GeneID" id="33557940"/>
    <dbReference type="InParanoid" id="A0A1Y1UFU2"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="511" mass="55234" checksum="F6E1F7769B80364F" modified="2017-08-30" version="1">MEVSEVSRTKRLAQAGSSVIFCFFLVGIVFGFAALKPILVDSGVYSEYCNGQERCKKQDTKLNQLFIIASSVNNIGALPMGTYLDRVGPRAATLTGAVLCMTGSILFSLGIVKPYFDSYIAGFALLGLCSPAIFLAQFHLSNTFPSRSGLILGSITGAFDASSLSICLYKVAYFRFGGKTSLRVFFLCYAVIPGLLIIQQLTFGPAVAYERPNSKVGDDSLPDQPVRPTLPPPSGSARDRKFPARPPRRRASSSFSRISYDVHDAANDEDVKNILGKDGEADPIVGALFGLGAGKQVLSKWWLAMEFMVIVHMTRINWYLTTVGSQLVYYTGDEGLADKLNDAFIFLLPLAGLVSIPAIGYLLDTRPLIVTVLVMTVMGVLFGGLTLLHGPVPQLIGLGILVVFRPLFYTAMSDYGAKVFGFQTFGTVYGLGMTLSGVFGFVLTPLDLLTKGPLNGSYTPVNLTLLILGLISGLTMAYVIWSHSRQGRIILSDSSVVNRHTAIQEEDEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFY9</accession>
    <name>A0A1Y1UFY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_651666</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870527.1">
        <property type="nucleotide sequence ID" value="XM_022018371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFY9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFY9"/>
    <dbReference type="GeneID" id="33560180"/>
    <dbReference type="InParanoid" id="A0A1Y1UFY9"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX36426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="305" mass="34247" checksum="37DC219F9C0EA68E" modified="2017-08-30" version="1">MRSEHETPQASGSQILRAQQRDASQIARLVQLTKDLLRSLNGSTWIIHKELIIDALVKAVYLFLTLGCGSPSLGEEYTDIMPIARRARGLSRLRRISAVLMLIIPNLVLEPSTISWLRNSVPQNGWHDLRRSLASVLESPLCQIIPELNIIAFMFSGSFLELGKRFTGIHYVTTAPDTRFPSYEPLGIVLLVNMFLRRLRRRRNLPLEPLTISEDSIHPLADPPKESDPVTEIGDNTYLTARARGIPDRQCSLCFEPRGTTGGTVAVTECGHVFCWECLGGLEKSECPLCRQDLRMERLIAAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG40</accession>
    <name>A0A1Y1UG40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_656257</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871051.1">
        <property type="nucleotide sequence ID" value="XM_022018838.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UG40"/>
    <dbReference type="GeneID" id="33560647"/>
    <dbReference type="InParanoid" id="A0A1Y1UG40"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF2">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1479" mass="165427" checksum="371204D12B4A87CE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGD6</accession>
    <name>A0A1Y1UGD6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase phosphorylation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870643.1">
        <property type="nucleotide sequence ID" value="XM_022018258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGD6"/>
    <dbReference type="GeneID" id="33560067"/>
    <dbReference type="InParanoid" id="A0A1Y1UGD6"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="135" mass="14899" checksum="6E4A1B8FAADD99C1" modified="2017-08-30" version="1">MYDGPIREGTRGGAGDFRWSQVKDDKHRENYLGHSIQAPVGRWQNHKDIHWYNREDGPSSSEAAAQAKREEIRKLKEAEEEALAVALGYAPRKKAEDEGAEGGGAGTGANAVKVEGGRAEEIAKLEKEEKKREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGY7</accession>
    <name>A0A1Y1UGY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871330.1">
        <property type="nucleotide sequence ID" value="XM_022018230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGY7"/>
    <dbReference type="GeneID" id="33560039"/>
    <dbReference type="InParanoid" id="A0A1Y1UGY7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="18954" checksum="E104619FA71D30C3" modified="2017-08-30" version="1">MAPILLQVFNQTIPSLSQLPSFTQSLNAVASTVPGELVKAITSGEACNGSVATGFASVVVRGGTQAVHAIGGKGIIVIGALFPVGCLTAFFARKRRRDTYAAAPIPLNGYSQPVYASSYYPGSPPPPFVAPLSPLPVHKQTLYGPPAVVDPMTGYYTHRHAGPPPKHVRFGDTSMRYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH08</accession>
    <name>A0A1Y1UH08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_468360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870855.1">
        <property type="nucleotide sequence ID" value="XM_022012870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH08"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH08"/>
    <dbReference type="GeneID" id="33554678"/>
    <dbReference type="InParanoid" id="A0A1Y1UH08"/>
    <dbReference type="OrthoDB" id="2552978at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42811" checksum="ACA1FF6506C23C5E" modified="2017-08-30" version="1">MPASAYKSGGRGGSGSRSQAAREPPVSLHMHQPTYPPSNATIQAYEANLIWDEPERATEQAQKSTELSHGRRSAGRGLIQWHGEEGEEDIWIDRYDILHLLPSLPSSGPSRSRHGQGRSPPPNPPHSPTASSSNSLSSSWADLPSDLEQTFELSSDEEFEAYEREKKKKWIDALREERLRERAKEDQVREREDESTAKAKSATVWKGDDEVPPDPILTLMSHTAMSLSKSPNPSLLEMRILANHSTDERFAFLRGRWKDIWVRIKDEVRRQRRVEPGLKEKEERNVGMLVGGYESDEPEDEAEEDEEEEEQMDRESREPSNSPPPPPPSPPGDPPSQGDRRQSPIRLPVVANANDEDKRLERRRKVEEWKMRREAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHI7</accession>
    <name>A0A1Y1UHI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_627828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871025.1">
        <property type="nucleotide sequence ID" value="XM_022016047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHI7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHI7"/>
    <dbReference type="GeneID" id="33557856"/>
    <dbReference type="InParanoid" id="A0A1Y1UHI7"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="331"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="647" mass="70605" checksum="8CDE71C3ECC66017" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI99</accession>
    <name>A0A1Y1UI99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_562606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871305.1">
        <property type="nucleotide sequence ID" value="XM_022013019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI99"/>
    <dbReference type="FunCoup" id="A0A1Y1UI99">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI99"/>
    <dbReference type="GeneID" id="33554827"/>
    <dbReference type="InParanoid" id="A0A1Y1UI99"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="326" mass="37702" checksum="977FBFA5645E8FEB" modified="2017-08-30" version="1" fragment="single">MTSMDLRVGGKYRIGKKIGSGSFGDIYLGVNIVTAEEVAIKLESVKAKHPQLEYESKVYKSLAGGVGVPFVRWYGTECDYHAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRVEYIHSRNFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHLHIPYRENKNLTGTARYTSINTHLGVEQSRRDDLESLGYVLMYFLRGQLPWQGLKAATKKQKYDRIMEKKMTTPTESLCRAFPNEFAIYLNYCRSLRFDDKPDYSYLRKLFRDLFVREGFQYDYIFDWSVLSGQKQGAAQDQVAQMQGMQHPTKIRVRPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIF2</accession>
    <name>A0A1Y1UIF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_579839</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871314.1">
        <property type="nucleotide sequence ID" value="XM_022013411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIF2"/>
    <dbReference type="FunCoup" id="A0A1Y1UIF2">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIF2"/>
    <dbReference type="GeneID" id="33555219"/>
    <dbReference type="InParanoid" id="A0A1Y1UIF2"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 13" id="KW-0288">FMN</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
    <keyword evidence="16" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="15">
        <location>
            <begin position="394"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX37276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="521" mass="56726" checksum="F5EB6B9743F6B820" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIL2</accession>
    <name>A0A1Y1UIL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_651418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871014.1">
        <property type="nucleotide sequence ID" value="XM_022018331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIL2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIL2"/>
    <dbReference type="GeneID" id="33560140"/>
    <dbReference type="InParanoid" id="A0A1Y1UIL2"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="335"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="44309" checksum="399E68DB4D70B65F" modified="2017-08-30" version="1">MSGLLDPIFGPGDSDDQTRPSNMAQEPPKEGPIAPSSSTIATTSAVQNQPDTSTQPTTSPTTTSTQQQQQQPQTTTQPTTSSTTTSSSTPAASPPPQSSSSAPPVASSSAVVTPSSSSSTTTVNNAPTIIDVPSSSTTTTATPIEQSTRTVVVVASGTVSVPGLLSISASRPTGSSIADNSEGKGGVGGSGLPLGAVVGIVIGGLVVIAIIAILATRTVRKRARERRTAHRSSMFEPWPAPVALEDEPYEKPSYADTAQSYPMQDTNTDGYHDGSYPAYGASQAYPAYDQYGQATQPYGQQPYMDAGIAGAAGMGAGAAAVAGVATGPGAEAGLQDNMMVRVKVGFVRSLEDELAITPGQQLYLHTSYDDGWCLCEDQAQNRGVVPVSCLEPWDDNANNGIVPSASEGALTNMSQRRSSLYQVSPIPEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIM1</accession>
    <name>A0A1Y1UIM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_626069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871445.1">
        <property type="nucleotide sequence ID" value="XM_022015867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIM1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIM1"/>
    <dbReference type="GeneID" id="33557676"/>
    <dbReference type="InParanoid" id="A0A1Y1UIM1"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="365" mass="41090" checksum="844E9CC7A70907A2" modified="2017-08-30" version="1">MPSELLHIPPAYVLVGIYRLLTDPFIRQPVLDKIKHASVRGLIVGLLYSIGSWRILNWFVRKVLLGRAGWLLGGGARARVGEAVKESVAGVVKVGLGPLSFHVDLVLYTHLLILLPQVSSILRMFIYKNLRIARSRAWALTVSSRGKPSEFWSQGYIEEWAQPPKPSASDLSGKGGRRTKEARWLSWLLWWPTQVVLRHYILLPLSPTLPLLSPLVTALLRGLTTAEYLHQPYFDQKDMSPESRWTWVEERMWAYRTFGFAASLLERIPIVGLFFSISNRIGAAMWAFDLEKRQHLFANEILKPLQPNQVGLFGMGSVTSADFDVQAAEDGLERKWSKKADNEKGIAELKGEGIGASQPGEERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ15</accession>
    <name>A0A1Y1UJ15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">endopeptidase La</fullName>
            <ecNumber evidence="8">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_622336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871534.1">
        <property type="nucleotide sequence ID" value="XM_022015465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ15"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ15"/>
    <dbReference type="GeneID" id="33557274"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ15"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1 9 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="657"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="859" mass="93729" checksum="3E499D6660ADB053" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ48</accession>
    <name>A0A1Y1UJ48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_624922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871173.1">
        <property type="nucleotide sequence ID" value="XM_022015750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ48"/>
    <dbReference type="GeneID" id="33557559"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ48"/>
    <dbReference type="OrthoDB" id="10687546at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="407" mass="43862" checksum="B826D7234DCCA256" modified="2017-08-30" version="1">MHAHTRHTVPGIRQDSELYDPGQHTDRSTPPPGRDWITQHPTQFYAILGGVLGMILVVCLYILWRGPHRNMFICCRRHKAVEDGGVNQVLSVGIWGGKGAAAVFPRPGVYLTDLKRQAGSSSVKDLHSNIQIHPVLSSFNVEKGLVKGSAQIKTGPTIIDCGMSGVPLPGPEISSNQSVPASPPASTYTFRAFTPGRGDPINTTVPNSPSPQSPIPRTPASKLAKDWKRDDEKKRRDTTVTKKSSGSSFGQSYPLNGAAGSYTGSRTSLDSLNRDSGGVRLASPFLASSKPVIRPLDSPRLPHNHPPPLPQQRADASLDFYTPRDRLADQRAVLPPPKSRRPPTNFSFETGSTPSMYSTSTPAQSMYIPTSNNNHISTQKHTGSIASSYAGQSAGSVPLPQSDKQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ87</accession>
    <name>A0A1Y1UJ87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_624283</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872026.1">
        <property type="nucleotide sequence ID" value="XM_022015679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ87"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ87">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ87"/>
    <dbReference type="GeneID" id="33557488"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ87"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="35453" checksum="63FA3ABE8A9CC73B" modified="2017-08-30" version="1">MSITALRRLSTTLYHLSPFKTLGIMAGKSEYSTRQIGAANTLEHRVYLEKDGKVISPFHDIPLFADESKNILNMIVEVPRWTNAKMEISKEEGFNPIKQDIKKGKLRYVRNCFPHHGYLWNYGAFPQTWEDPNAKHPETGANGDDDPLDVCEIGEAVGYTGQVKQVKVLGIMALLDEGETDWKVLVVDVNDPLAPRLNDIEDVERHLPGLIRATNEWFRIYKIPDGKPENVFAFSGEAKSKKYAVEIILECHEAWKKLITGETNPGGISLHNTQVKGSRGLVSTSDAAYTSIPADSRKPPAPIDPSISKSFFISSASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJE1</accession>
    <name>A0A1Y1UJE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_386487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871573.1">
        <property type="nucleotide sequence ID" value="XM_022012646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJE1"/>
    <dbReference type="GeneID" id="33554454"/>
    <dbReference type="InParanoid" id="A0A1Y1UJE1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="210" mass="23693" checksum="BF5AFA2837A2CCE3" modified="2017-08-30" version="1">MPILPDSLADASIDTQDNRSLIMSSLKKARDAMDELCQAPTFEPSLMTDDDELTRELGRVQNSTNELSQRLRPHMRRRDLPEFHSYTCTVRLASRELKSILDSVKIPLSDPPDFEAAARVIREAEPALEYVRGTLSTGWPGERSRTSTPHLYRSICSCKRKEQIDETTMRTTGEMMRGVLSMLEDTDLRSLRQQMGLSNESADTDSPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJM2</accession>
    <name>A0A1Y1UJM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_622952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871691.1">
        <property type="nucleotide sequence ID" value="XM_022015530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJM2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJM2"/>
    <dbReference type="GeneID" id="33557339"/>
    <dbReference type="InParanoid" id="A0A1Y1UJM2"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="339" mass="36687" checksum="F5C1F152056ED732" modified="2017-08-30" version="1">MSTGDQSLQPPADGISALAFSADSQRLLVASWDGSIQLHELTIPPTAPRIFTHPAAVLSVTFGSSSNTAFSGGLDKRVREWNFETGQCRVLGKHDDAVSSIVWCPEKQILLTGSWDQTLKVWTPSSDSPLTSSHNLPNRIYSIAHSPATSKVLVSMAHRHVWVFDAGALASAAQGQTLQPEQQRESALKFLTRSIALMADGKGWASGSIEGRIAVEYVDPDPAAQAQKYAFRAHRQNVDGVDCVYPVNALAYHPQYNTFASGGSDGFISIWDHSAKKRMKLYSKYPTAISSLAFSPDGSKLAIGASYEHDNAVNESDRGTVMLLIKDTVNVDCKPKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJQ2</accession>
    <name>A0A1Y1UJQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_392320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871683.1">
        <property type="nucleotide sequence ID" value="XM_022012668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJQ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJQ2"/>
    <dbReference type="GeneID" id="33554476"/>
    <dbReference type="InParanoid" id="A0A1Y1UJQ2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="44075" checksum="4099A71BC7504483" modified="2017-08-30" version="1">MMSQRLLVQPEAIIGTLFALVLGRWLYNYLRVRLEVLGLPTTHSLFELFESGIRSKLPQTPFVSPVASLSLQKPFEKYANAKTDLLAFTQATTPYAVYATANPSVAASISNKPAKYVKPVRMFRYQAINRFGRQIVSAQNGEEHKRHKGVVRACFGKEIMETGWTTMVDAYQVMCREEGLENGGILKDVKEVLAKVTLLVIGSASFGVQFPYNSSTSEDALMPFSDAIQLVETSMIFQLPLPLWLMTWSPFPYLRRCAKAQRSMVKHINEMIASRRKQTTALQATLSADEQVLTQRDILGALVASQIQVEEGKKKNTAGLTADEIFGNAFIFIVAGHTTTAHTLTFALALMALYPQTQEDIVQELASVCGDEYPTYRHMSKLPLTLATMYEALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJR4</accession>
    <name>A0A1Y1UJR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_398860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871764.1">
        <property type="nucleotide sequence ID" value="XM_022012680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJR4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJR4"/>
    <dbReference type="GeneID" id="33554488"/>
    <dbReference type="InParanoid" id="A0A1Y1UJR4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="38795" checksum="4D77F75149188268" modified="2017-08-30" version="1">MTVVRVNTTPLRPARTPPRPAQTQITGDEDEPPPPPYAPDDPEPDQTRILEQRLISEAEAEGRISSELPGEPRYSPPAGPPPLSSSASRRTPPTPNRDRPPTPDSPPADEQVRLAWEESQLDEAKRASLAAEQERLELEEAMRLSLAEAEIAEVASSVAGPSTRPSNPRPLPDPRQSPQYNQFTAAQALSPPLPLRPQTSAESFKRPQQMPSQSSSPFSSPWVSQRASPSIGHRRTASDVGPGMARLSLNEFDPLAEDDGQMSSLPVMQPTQHAAVLQSNNPFLSPRERLETKSSNESLGKPSPPNTATTTTGQIPQPRRTMSTLAEGEDPLEALRTCDTVFLSEHRKRSGMLTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJX2</accession>
    <name>A0A1Y1UJX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871791.1">
        <property type="nucleotide sequence ID" value="XM_022015574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJX2"/>
    <dbReference type="FunCoup" id="A0A1Y1UJX2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJX2"/>
    <dbReference type="GeneID" id="33557383"/>
    <dbReference type="InParanoid" id="A0A1Y1UJX2"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48561" checksum="457339E92595F7C2" modified="2017-08-30" version="1">MTTMTTQAAAAPPPLSLYIEDDAASFRQSRMMSQPAPLMDQSHLRPGKQAALLSHDRTLELYRENAKKTNDPELIFEFAVFMIDAAKTMGQSDMDDPSARGQDGRAALVKDDKKDELIKEATTLLKRLADRGYPDAQYFLADCYANGIGTVRGKQDFDRAFPLFVLAAKHGHPDACYRAGTCCEHGWGCRRENPKAVQFYKKAAVALHPGAMYRLGTAELNGSLGLRKSPKEGVKWLKRSAEHATEEFPHALHELALLHERGIENVVFVDVDYSAELLAQAAELGYAPSAFKLGDCYEYGRMGCPADAALSIHYYNIAAMQDHRDACFALTAWYLVGSPGVLPQSDTEAYLWAKKAAELGLAKAQYAVGYFTETGVGTAPDLNEAMKYYRKAAEAGDKRAQKRLLANNRTGVHALDRRLEMEAMKEDNGLGKSKGDGCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKP4</accession>
    <name>A0A1Y1UKP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_577419</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872464.1">
        <property type="nucleotide sequence ID" value="XM_022013256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKP4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKP4"/>
    <dbReference type="GeneID" id="33555064"/>
    <dbReference type="InParanoid" id="A0A1Y1UKP4"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="11">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="692" mass="77242" checksum="9B7074BD71BFA747" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKU7</accession>
    <name>A0A1Y1UKU7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872600.1">
        <property type="nucleotide sequence ID" value="XM_022018078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKU7"/>
    <dbReference type="GeneID" id="33559887"/>
    <dbReference type="InParanoid" id="A0A1Y1UKU7"/>
    <dbReference type="OrthoDB" id="2590631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="44579" checksum="DFDEEA9CE7CFC3BB" modified="2017-08-30" version="1">MSLTPPLYCALCSARCLVPRIELPLPAPRPGGLSLNTDTVGSQPPSPGMKHDPSTWEKRWFVLQVSNGLIQPPLASQIHSEPTSPLGSGPSTDSTVSRMNQRCVPIHAYCLTCVLGTVRRSMYNNGFSHEENMILAWSIPKWTGHGDWTYPSDLEPSRSPTGSFSRLRSAYWSGTESQRRRWDPEIEGSHLLPEDMVSPEEVGTPKSILPDRNASRLPQASLLLAIPEHILRNIALELVNVPHDENETIKRNTASRLLPMNDITDLLSFTRTCADCRYLTLPAWLWIRILSDAVARFKLSLLSRWRANPTGVGSTMQLAISLDEAFTAPVEEAVSHLAWDLDDVAGWDDDKHRRTPITARDLFFWWSYSDSWKSRRRIWYTVVHACATARDADWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL21</accession>
    <name>A0A1Y1UL21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_589176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872604.1">
        <property type="nucleotide sequence ID" value="XM_022013775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL21"/>
    <dbReference type="FunCoup" id="A0A1Y1UL21">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL21"/>
    <dbReference type="GeneID" id="33555583"/>
    <dbReference type="InParanoid" id="A0A1Y1UL21"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="413" mass="44273" checksum="E4E4967F1E097EA2" modified="2017-08-30" version="1">MAPQKIIIDTDPGVDDVLAILMALASPEVDVSLISIVFGNTHAPGAHSNLLKIYHLLAQEVAAVPAAAARYHRLEGQTKTRLALGDDSPIGGEKAVAAYFHGLDGLSNISETHPEFTPPPLDPGAVHAHLDILKTPAHEVILETLKSEPEGTVTIVALGPLTNIAHAYQADPVTLARVHSVVWMGGALDHPGNTSPVAEFNCFADPYAATIIMEACKAGEIKLVIAPLDITTPHTIPFSDLIDPSIGIPPSDSSGQSSKLSPPGPLKTFISHMLSRVRGLHVSFGLPDAMEMHDPLAVWYALSNASRAPLDTAEGWHLRPRDFKVERKGEFTRGMCVVDRRGTTEDQGENRAFDLAKEHNANKTEASAVDNGERDRDGSKIVKAGHLPMVIVKTPGKEVLRSLLLDRVFGQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULC8</accession>
    <name>A0A1Y1ULC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_623786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871902.1">
        <property type="nucleotide sequence ID" value="XM_022015626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULC8"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULC8"/>
    <dbReference type="GeneID" id="33557435"/>
    <dbReference type="InParanoid" id="A0A1Y1ULC8"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="378" mass="40826" checksum="AC74AE11C54CBBC5" modified="2017-08-30" version="1">MVLGMLARLSSNVCCFLYPAYASYKALSMTPESSPEAMAQVEKWLMYWSVVGTWTAVEAAVGWTFTWLPFYSVIKAVVFIYLSSPQSGGSSWIYRTQLAPFFRDHETDIDGFLTSLKGRAGTAVSEAIQWAWNKAKTQLNVSPNSENTGSHQPAVPTHQPPSMQDPASGPALQLYGLLSRYAGQYLPVALSALQAAAASNRSRQDRDSTPVAMQVPESMAMPTPRVNQADHTGSLRSRTYQQASAPQSQSGSHDPRDDHNSSWSRSPLPTPPSFGNSQFPGGSPHRPGMSLPGSRDGSDGLSAHSSQESLGRASASTSASRFGGESYEHVNRDEVRNISQSEFGQGTPTGRPAMTDKRRGSWFGWGGASPNQGRAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULF2</accession>
    <name>A0A1Y1ULF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_655219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872675.1">
        <property type="nucleotide sequence ID" value="XM_022018810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULF2"/>
    <dbReference type="GeneID" id="33560619"/>
    <dbReference type="InParanoid" id="A0A1Y1ULF2"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="154"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="320" mass="32116" checksum="6384B7484D5F3B0D" modified="2017-08-30" version="1">MDFIKKFAEEQLEKQFEGQQGGNSGGGGGYGQQQGYNQGGGGGGGYGGDSDYNQGGGGGYGGGQGSGGYNQGNEGRYNEGGQGGYNQGGQGGYNQGNQGGYNQGGYGGGGRQDYDQDQGNNDRFGVTGGPQYNAPHGQGGAGGFQGGGKPHINEDEALQAANQFNSNGNEHASMFSHALGRINNMNPDDTDLDEDQVQRQHQQAYGQQNAGSMDANSMGSAAAMQALKMFTSGGGGSASSGGSSAMIGMAMSEAAKLFDQSGGAAQGNKQDAMTSAGQTIMKLLLKQKMGGMMGSGGSGMMGGGNSGGLGQLMGMASKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULU5</accession>
    <name>A0A1Y1ULU5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_305112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX39028.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012442.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="33554250"/>
    <dbReference type="InParanoid" id="A0A1Y1ULU5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <end position="107"/>
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            <begin position="150"/>
            <end position="159"/>
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            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="285" mass="29814" checksum="D3EC02A74CB6B8CC" modified="2017-08-30" version="1">MALGVRVVSNTTTHPNKAFWEASLLVAILLVVLLVSLCSWGGGWLWGNSDGSSPRKPRSDPPTSTGAPASTPSPPGAPPQDPPDSPTTPPGTSPRSTDSSGTDSDSGGSHDDEEDGTRSPGNAVNSRVPPGFNAQTYHLPGGNTVILRTPIDETDREGRTTTITTGGMNRPVTDGQGGRSAYIPFEVPRSSFPGNTTFAQQQGRPAQSGASPAVQLPPSQQQHPAPPGEPRAVNLPPVTPLSPNVIVSPTLPPPRRDVLNMMPQNLQPTIRHTPVNVSLGAHWQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1ULZ6_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_308965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
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                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
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                <person name="Daum C."/>
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                <person name="Spatafora J.W."/>
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            <begin position="54"/>
            <end position="156"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="66"/>
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            <end position="114"/>
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            <end position="124"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="135"/>
            <end position="156"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX39071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="156" mass="16840" checksum="689EFFDD191D9B2B" modified="2017-08-30" version="1">MNLQAKYASPLLCLQPHEDGSLEPLSDLAVAPSFFSTWPFRIAMRLARSAFSHLPPSVQSSLPVSLRAHQQPIESESNTAEGFDVSPTNGSTSRSKQKPRSQGTDTPNTATSLSDSEEGDENDETPNGSGTEAKPKKKRGPGKAAGMRRRKMGMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMD6</accession>
    <name>A0A1Y1UMD6_9TREE</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_618715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX39169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022015072.1"/>
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            <begin position="1"/>
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        </location>
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            <begin position="17"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="346" mass="36381" checksum="92264C3D785613EE" modified="2017-08-30" version="1">MKYIALGLAVAGLAAAQNSSLIPANISSTCNTFLTQLNNDDSLSNCIQPLLNATVQFSPVSNVTLNEDDINTTLGAICNTNAGCADSTIRQWLSEFYANCQAELTGQSTYSSDVRELYDVLYVANPLKAAVCSVNSANQDYCIKDISTSEKSGNSSTSSSAASSSASASASASGVASGSLFTKWSPVEFAAANLYITIPQTVSQMTKRMLEYFSPRGEQSPFSIIKPNTTTYRNTNLPFLFLQDDMTSSQLCTPCTREVFVAYIKWESQMPYALGLSQSPILGGQNQLWRSVNATCGAGYVESIISEVGSGNFASSGIGAAAGTLSTIPGLGMGLAVLAGSVALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMW2</accession>
    <name>A0A1Y1UMW2_9TREE</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873261.1">
        <property type="nucleotide sequence ID" value="XM_022012505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMW2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMW2"/>
    <dbReference type="GeneID" id="33554313"/>
    <dbReference type="InParanoid" id="A0A1Y1UMW2"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <begin position="1011"/>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="902"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="968"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1194" mass="127153" checksum="ACE3D3A5577AC98A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNX2</accession>
    <name>A0A1Y1UNX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872678.1">
        <property type="nucleotide sequence ID" value="XM_022017907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNX2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNX2"/>
    <dbReference type="GeneID" id="33559716"/>
    <dbReference type="InParanoid" id="A0A1Y1UNX2"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="583" mass="64222" checksum="B5DCC919B8FF0969" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNZ1</accession>
    <name>A0A1Y1UNZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_649276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873049.1">
        <property type="nucleotide sequence ID" value="XM_022017964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNZ1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNZ1"/>
    <dbReference type="GeneID" id="33559773"/>
    <dbReference type="InParanoid" id="A0A1Y1UNZ1"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="139" mass="15040" checksum="D3EACB2C6E6453FF" modified="2017-08-30" version="1">MTEALDRPNGQSTPQDDQIIDAPPELEATLARLSAYRKVRGVMILSRGASTTQRADGQASAGEASQSGILRRTGSVFEGNGGEKYASAVEDIVLRVGKAVASCEEGDEAKLMRIRTKRHELIITPNDRYLLVVLQDPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNZ9</accession>
    <name>A0A1Y1UNZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_618794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873059.1">
        <property type="nucleotide sequence ID" value="XM_022015084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNZ9"/>
    <dbReference type="FunCoup" id="A0A1Y1UNZ9">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNZ9"/>
    <dbReference type="GeneID" id="33556892"/>
    <dbReference type="InParanoid" id="A0A1Y1UNZ9"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="9">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="8">
        <location>
            <begin position="171"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="295" mass="32517" checksum="656F998FC00A18DA" modified="2017-08-30" version="1">MSSAEASSSKLPPIQKGASLMIAYRLEDRPVLLIGGGVVAAGRLFFLLEAGARVTLVSPPPLHPDISERLSTNPHDITWHSRSFDPVNDDIHVQDFAMVLTAIDEVEISRQICDLCREHRVPVNVADIPPSCDFYFGAQLRRGPLQIMVSTGGSGPKIGAMVRDIVDRALPENLEEAIEGVGLLRGDLRVRAQGVGGSIGRRRMQWMIGICDAWGLESMAKLRDETVRKAVLDHGWEGDRVVRPSDVGLREEKNRRRRLIDWSYAGWYAAGLGGMVTGMTLGMVGTIWMLKRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPQ3</accession>
    <name>A0A1Y1UPQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_616018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873823.1">
        <property type="nucleotide sequence ID" value="XM_022014783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPQ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPQ3"/>
    <dbReference type="GeneID" id="33556591"/>
    <dbReference type="InParanoid" id="A0A1Y1UPQ3"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="812"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1199" mass="133700" checksum="7E6C6D8CBCB7004E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPS2</accession>
    <name>A0A1Y1UPS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD324DRAFT_644540</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873808.1">
        <property type="nucleotide sequence ID" value="XM_022017594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPS2"/>
    <dbReference type="FunCoup" id="A0A1Y1UPS2">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPS2"/>
    <dbReference type="GeneID" id="33559403"/>
    <dbReference type="InParanoid" id="A0A1Y1UPS2"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="45"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="275"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="490"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="587"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="684"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="767"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1144"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORX40023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138445" checksum="3ACC2BA43F4E1C57" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPU8</accession>
    <name>A0A1Y1UPU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_648238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873382.1">
        <property type="nucleotide sequence ID" value="XM_022017807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPU8"/>
    <dbReference type="GeneID" id="33559616"/>
    <dbReference type="InParanoid" id="A0A1Y1UPU8"/>
    <dbReference type="OrthoDB" id="3365310at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27752" checksum="37174ACCAF7D7D07" modified="2017-08-30" version="1">MPPFQALTLLQHLRYPSTLSLLGLSRAFGSAAATPSNIECTRFLPRHPSPIAPRESPTPLVLIRARGLGLDESSEEREWTTWSAMFAEKGYTAVEIDISVSAKAEGGSAGASGPTGLSDPSTLPSMAKVLSGQIRLMAVPFPPIVIASGPSCLLAQTFVGDYPVSGLVMLDPPSDEAPKTLKDKSSWPMFNYEPKFPILVMADKDQVDTLGQRNRVAKAAEDGVSRGGKGVSIETMVDGIRGEKTRTEVERWMDRCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQB7</accession>
    <name>A0A1Y1UQB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAR-17a/AIG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_648325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873479.1">
        <property type="nucleotide sequence ID" value="XM_022017823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQB7"/>
    <dbReference type="FunCoup" id="A0A1Y1UQB7">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="GeneID" id="33559632"/>
    <dbReference type="InParanoid" id="A0A1Y1UQB7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="28792" checksum="3F93E264104E8C81" modified="2017-08-30" version="1">MSKANGGPKMTPISKDDSRDEVKGSKKSYDASRPRRHLGHFLFHSCTAGQMLNGFLGLNAIARDNKVEAQYGGFLQYLTIVGLFISITAMLLSSMKDLVPSLRKLHRIKRGLLLFALPVEIVIASIYWPLAIFAPSLMFPKSPEDVSSPVPSSVPATDLLFKIPLNMDLSMHALPAFALLFDFFFLEKKYTPPASTIGAPLLALTFGTLYGVWVEHCATINGKFPYPFLNVMDFIPRVILYITATFGSLFAFWGLNGLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQD3</accession>
    <name>A0A1Y1UQD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_617068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874036.1">
        <property type="nucleotide sequence ID" value="XM_022014875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQD3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQD3"/>
    <dbReference type="GeneID" id="33556683"/>
    <dbReference type="InParanoid" id="A0A1Y1UQD3"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="112"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="34686" checksum="2749805E76A154FE" modified="2017-08-30" version="1">MSVRRADVTKSGNSGHLPYQQTGICSSLSLSLFHQLITTMAPHIPFKEAEASRPPFDRKAELHYTQTPDPNWKLGQGVNDLPGADKFKSQEGWRAIDPEQMEGPAMYKMMISAIVPRPIALVSSMDDKGVGNLAPFSYFNMVSSSPPVIMISVAANPQTTDGLKDTASNIKHLKEFCVSIISEPFVEAANMTSAAAPREVEEWEVSGLTKRDSKMVKPPHVGESAFSMECRLEHWYDVKKDDGKIASTVILGRVLQFHGKEFVFDPNDPDRIMAEELRAVSRLGGISYGRTLQMTELPRATNWDDVKAEMKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQF7</accession>
    <name>A0A1Y1UQF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_575510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873471.1">
        <property type="nucleotide sequence ID" value="XM_022013132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQF7"/>
    <dbReference type="FunCoup" id="A0A1Y1UQF7">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQF7"/>
    <dbReference type="GeneID" id="33554940"/>
    <dbReference type="InParanoid" id="A0A1Y1UQF7"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="92"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="59267" checksum="DD4E1F5703550B49" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQG9</accession>
    <name>A0A1Y1UQG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_614650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873481.1">
        <property type="nucleotide sequence ID" value="XM_022014623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQG9"/>
    <dbReference type="GeneID" id="33556431"/>
    <dbReference type="InParanoid" id="A0A1Y1UQG9"/>
    <dbReference type="OrthoDB" id="2575738at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="209" mass="23516" checksum="68B48D4CA61D57A0" modified="2017-08-30" version="1">MSRSFVPSRPAPSPPYAVKTPNLPPNHPFATHYVPTHRSSVEVSPRHRSLPATFSSSSSDSSSWGSFRSNTSTPIESAARSSTSRLAQPLSPHSRFYHSERPINEPAPQAPSSPFTLPAELSLFDPKPRENLVSDLETIFGTNLRPRFFARSIKVKSKATQSNEPKDKTIGRPRRILKKARERSWEDDFVWGELKSEEDEKSVYRGSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQT9</accession>
    <name>A0A1Y1UQT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_658455</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874127.1">
        <property type="nucleotide sequence ID" value="XM_022018883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQT9"/>
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    <dbReference type="STRING" id="4999.A0A1Y1UQT9"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
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        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
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        <property type="entry name" value="SET DOMAIN PROTEINS"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="18">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="124"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="534"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="651"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="550"/>
            <end position="569"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="673"/>
            <end position="682"/>
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    </feature>
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        <location>
            <begin position="703"/>
            <end position="713"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00004286"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00030091"/>
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            <dbReference type="ARBA" id="ARBA00047545"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50280"/>
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            <dbReference type="PROSITE" id="PS51215"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX40448.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="721" mass="82080" checksum="17C21DC83BAFEEDE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR40</accession>
    <name>A0A1Y1UR40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_616095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022014791.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="94" mass="10923" checksum="4E8E0279A48080D9" modified="2017-08-30" version="1">MIDLHTQLDDEIELIRASLLPAEELTTTDQDDWPRVLTIDSKDSKLSLQLRIQQEYPSPSSLQVEIRGDIGKDEAEEWRSWTAERLKDWQAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR73</accession>
    <name>A0A1Y1UR73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_247132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873759.1">
        <property type="nucleotide sequence ID" value="XM_022012273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR73"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR73"/>
    <dbReference type="GeneID" id="33554081"/>
    <dbReference type="InParanoid" id="A0A1Y1UR73"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="617" mass="68110" checksum="432B72182E5EA41E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URG0</accession>
    <name>A0A1Y1URG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_611201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874228.1">
        <property type="nucleotide sequence ID" value="XM_022014250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URG0"/>
    <dbReference type="STRING" id="4999.A0A1Y1URG0"/>
    <dbReference type="GeneID" id="33556058"/>
    <dbReference type="InParanoid" id="A0A1Y1URG0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="576" mass="62178" checksum="707A9A25C6E70579" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URZ1</accession>
    <name>A0A1Y1URZ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874487.1">
        <property type="nucleotide sequence ID" value="XM_022017704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URZ1"/>
    <dbReference type="GeneID" id="33559513"/>
    <dbReference type="InParanoid" id="A0A1Y1URZ1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012553389" evidence="2">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="346" mass="36337" checksum="9D31F8DA5057A43A" modified="2017-08-30" version="1">MRTPPQHLLCLLAFFHLVLSLPAPRPGKTTARLPRNTQPASETSFMPTVTVSLATLSVSSLGSASITASSSFPVSFWQSLKKINLLAGALNAFSPSSNSTPSAGASEAMPSGTTTYKGKKLFGIITCNFGGFGKGKKWGSGGGGGGGGGSGGNGDTGNGGFGGEGGGGNGDKNNFNSEQNEHNEQNEHNDQTSQNEQNSWNSFLSGFENIFQSQTWMSNAFSTKSWESDSWTSKWSSFNEWTSAWSQTEGWTSTWSSYDGWTSDSWTSDAWTSGGADGMRGSMTVQEGEPSFGASNAWSSTWESSEAWSSTTADTDINTQGAPSGFQLITITGSAGYPVVTQVPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US08</accession>
    <name>A0A1Y1US08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_647729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874502.1">
        <property type="nucleotide sequence ID" value="XM_022017707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US08"/>
    <dbReference type="STRING" id="4999.A0A1Y1US08"/>
    <dbReference type="GeneID" id="33559516"/>
    <dbReference type="InParanoid" id="A0A1Y1US08"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="29446" checksum="C5463C1BA509EC56" modified="2017-08-30" version="1">MSSPVSGHASKGATPIRHGSPVDAARPRLVSPRNSDGINTPTKRSTGGSGSGAGGAGSLEARRARRAELRQFYGIKEGQKADSGQSGDEAGKADSGDPLDIDSSSFNASKYYENLITTASLADLIKTANTLSADVGNLQGSRHALVYNHHHQLFAAGDTIAQLNSRTPQLLSIMTSLQDSFSEISRLADSVALPVDSTEHSSEESWAKNVERLRLMRVAEEPAERINTYFDSFRSRLETEAENSDNAKQALQSCMVLVNALEDDRDEAVVAGKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USD8</accession>
    <name>A0A1Y1USD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_612591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874612.1">
        <property type="nucleotide sequence ID" value="XM_022014409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USD8"/>
    <dbReference type="STRING" id="4999.A0A1Y1USD8"/>
    <dbReference type="GeneID" id="33556217"/>
    <dbReference type="InParanoid" id="A0A1Y1USD8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="167" mass="17918" checksum="A65F526D68484F37" modified="2017-08-30" version="1">MIQFSRPKKSLASALDPFKRHESTLSSEYMDKGRVPGPAPSRFDAYYRTHDLHGHVPPDAQSVISQAVTSFPMPKGKNYTGYASSVISQQPGETASVAGGPAPSIAFSQFDRLPHEANTDSKARRRLSFGSIAPSDAPTASMYAFGYKAGDDDAQSIAPSQAGMTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USE0</accession>
    <name>A0A1Y1USE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal subunit protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_612613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874617.1">
        <property type="nucleotide sequence ID" value="XM_022014411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USE0"/>
    <dbReference type="STRING" id="4999.A0A1Y1USE0"/>
    <dbReference type="GeneID" id="33556219"/>
    <dbReference type="InParanoid" id="A0A1Y1USE0"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="105"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="32559" checksum="7AFEF48BA44BE0FB" modified="2017-08-30" version="1">MAIPATRIACGSTRSIPLWARTFHSSCSSSAAKGKSDTPSAAIQKERAKVEKETKLPLMQNWKVYDYSEPPFLETVKMLEVQETWNLVEKLRENDALLRAQATPFTPPTNSVRLTRFIVPGAPNHPSSLRQQIVVPVSSLPLNTSEARHRIKLLAGSRWNPGRTDVDPCSIHANEGFNAGPQNIGKEGWLIISCDKFPEPRMNRKFVSDTLERLVEAANDPNSPLSTDIPIDTRHLKSARRSKKYGESKMRAIKTLESLKMQNVGGVRGFPVEWLSDEALSKPKYKKAMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USJ1</accession>
    <name>A0A1Y1USJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_612725</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874648.1">
        <property type="nucleotide sequence ID" value="XM_022014430.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1USJ1">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USJ1"/>
    <dbReference type="GeneID" id="33556238"/>
    <dbReference type="InParanoid" id="A0A1Y1USJ1"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="248"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="444"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="592"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="718"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1090"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1341"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="899"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1476"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX40969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1519" mass="164483" checksum="43BEA7E6D0A875BD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USP0</accession>
    <name>A0A1Y1USP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_616889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874000.1">
        <property type="nucleotide sequence ID" value="XM_022014865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USP0"/>
    <dbReference type="GeneID" id="33556673"/>
    <dbReference type="InParanoid" id="A0A1Y1USP0"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="42533" checksum="D644BFC2232A406E" modified="2017-08-30" version="1">MREYKHLTPEEREFFLTHGWLKVEGAIKQQYIDEWMKDFWVRLGYDEHDKSTWEEEYTKLPRHREVRCEEFCPKAWDKMLEIVGGEEVVDPVRERYYGDQFIINFGSEERTKQKPIHPREYRGWHTDNDWYRHFLDSSGNALTIIHCFTDIPERGGGTCVAEDGIKRLCEKLYEHPEGLDPPFPSGLLYSHVAKECEKFSHVVAKAGDVIITHGLLPHSHSPNYLHYARVITNPHLNMAVPFNLNREDGDYTLAEQVILRALDRTSIPEYKPTRERLATYPRTAYFKREKVKEELVRMIKDAESKGKSAKDVDSVYLRGEEAILEHERRNGYDKPWGPHGVQRHMKDNEEWVPTSTRHVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USW6</accession>
    <name>A0A1Y1USW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874792.1">
        <property type="nucleotide sequence ID" value="XM_022014480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USW6"/>
    <dbReference type="GeneID" id="33556288"/>
    <dbReference type="InParanoid" id="A0A1Y1USW6"/>
    <dbReference type="OrthoDB" id="2564511at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="30312" checksum="E7F241B18FE7BAB4" modified="2017-08-30" version="1">MTDSPPSSSSSSHPLYSLPHLNRSASSYNSAENGIPDGPEVDGSTYAALVKNSPSVAEPPLDLHDRDPGTARFADQGAIDLGDDDLGRYVPSTPIMPRETPQRVRGSYRTDSDDGGMGSILKSGNFLPPSATLGGTPATPAQSGLASLTPQKIGKSIGNRIVRAVRRGNLPFLVVFLSCLVIFFSALAGIGYVPEEGELAHHAKSPRAVVSAVAQDLQVFNGKKFQEQRELEQEWAKKKRPKDGAWMAQVRDDKAVRRRPNAVAEVAETPSESELEAKPEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USZ4</accession>
    <name>A0A1Y1USZ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874810.1">
        <property type="nucleotide sequence ID" value="XM_022017763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USZ4"/>
    <dbReference type="STRING" id="4999.A0A1Y1USZ4"/>
    <dbReference type="GeneID" id="33559572"/>
    <dbReference type="InParanoid" id="A0A1Y1USZ4"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="2">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="252" mass="27672" checksum="67BF4F398C1A4E1C" modified="2017-08-30" version="1">MTCPSISSNGFLRGLKASTSVLNRPLNGSIRAFSTSSPALVGKPVLVELLQRVPGLGHPGDRVHVVSGRARLDLVPLRKARWVPFAEKFGLGPSKANRVKSQGIRARRSKAEPDTPTEEPKPFVPITPTPAALKSKIDSFPPVLDFNLQTVSMDSSVLITTFTLGDITNTLKDYGLTKEDVLLRWEDGKSDRIERVGERVLVLQVRGRGLEEKKVTVRVHRTSRDVSSWAEERALEKEQAETSLKGESGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT05</accession>
    <name>A0A1Y1UT05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_648038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874827.1">
        <property type="nucleotide sequence ID" value="XM_022017765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT05"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT05"/>
    <dbReference type="GeneID" id="33559574"/>
    <dbReference type="InParanoid" id="A0A1Y1UT05"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012598425" description="Amine oxidase domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="63786" checksum="91D8A67F01973A00" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTC1</accession>
    <name>A0A1Y1UTC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874940.1">
        <property type="nucleotide sequence ID" value="XM_022017790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTC1"/>
    <dbReference type="GeneID" id="33559599"/>
    <dbReference type="InParanoid" id="A0A1Y1UTC1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="271" mass="29036" checksum="95A6D7AA081E5EEC" modified="2017-08-30" version="1">MAPYSPVPYRPPAHRSHSRASTLTFDDRPHPRYSGLLGNPSRRSSGLLSTCTAAERRWLTLLACIVAGLILWLLIGPAMLQHRHLQQAKLNLELEAEESSASSLAAEASTTPAIIPSSPSSETAASPSATDTITGSNSLTTVYVDPAILSTATVSKSTIASFVSPSPTLHPWAALNSVFAPTTTYQAIMPSRRAKSKTRPFEPPKPTVKAPWIKVGPMMRAVHSARSASSKAAATGGKWIPDRKIKYADIAATTSTIRPSASARVWMSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTC5</accession>
    <name>A0A1Y1UTC5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_613598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874881.1">
        <property type="nucleotide sequence ID" value="XM_022014515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTC5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTC5"/>
    <dbReference type="GeneID" id="33556323"/>
    <dbReference type="InParanoid" id="A0A1Y1UTC5"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="554" mass="59540" checksum="B69112F7B08096A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTF1</accession>
    <name>A0A1Y1UTF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874970.1">
        <property type="nucleotide sequence ID" value="XM_022017798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTF1"/>
    <dbReference type="GeneID" id="33559607"/>
    <dbReference type="InParanoid" id="A0A1Y1UTF1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="300" mass="33801" checksum="364C7AEC129A4F8E" modified="2017-08-30" version="1">MGSIPAVLHTGMTHLVKIHPAIPDDIPTLAEINWQAYRTDPMFKVGFVNWPDDEHMKPFFYGRVKGRFEIPKTVMYKAVGEADGVIHGFIALTEEEDKKQEEGEVREAEDGANEDIKQEVQMQNGSSDEPRHSAQISDTPSTTAATPDSLTTLRPTININELSKNTGTAEYFKAQNNSHEFTLPDYLNAEMMLSTRDGIMPMMNAIAKSGKHYYISAFAVRPESQGQGIGSNLIDHCIKVVEKDPSKIPIWLIALPSSHHLCLTHGFVDKDHCDMDLDKYDAQRRQLGVYRQWAMRRETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU22</accession>
    <name>A0A1Y1UU22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_43104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874806.1">
        <property type="nucleotide sequence ID" value="XM_022012769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU22"/>
    <dbReference type="GeneID" id="33554577"/>
    <dbReference type="InParanoid" id="A0A1Y1UU22"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013095910" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8808" checksum="2A99A15D4367F1E5" modified="2017-08-30" version="1">MSLSLLFSLLFLRMPLGGKFQAENIGQSRNSHHVGRWGGTWRSSKSRPDVTVSKSLGGEQCLGMQWPVVKISQAHACRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5J2</accession>
    <name>A0A1Y1U5J2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_640205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000027">
        <property type="protein sequence ID" value="ORX33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867650.1">
        <property type="nucleotide sequence ID" value="XM_022017329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5J2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5J2"/>
    <dbReference type="GeneID" id="33559138"/>
    <dbReference type="InParanoid" id="A0A1Y1U5J2"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF11">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="416" mass="46082" checksum="D773EA8F2494DAC2" modified="2017-08-30" version="1">MIEVLSTESPCPARTRSLHDPFPLGTLDVLVPIVIPVAVVFVYRTPVDPQILRDALARLLEVYPQLTGRLQEDTLGNRFITSIGSGVLFETARCSDGLPEKVTMVDLPGEGNDLFASFTPDATAVSNGPILSIRHTSFACDSVSLGIRCLHTVCDAVGFFQLVRDLAQVYRNLRDDKQALDGVDLPTIIPLKAPPGGSTTLFTLTPLTPQPTASDPATGRFFHYTPDQLDSIKRRTSVGTFSALCAHLHCRIYQARARVYDALSPPDLLTPVDLRRRYPFPPRYFPQAVLTTWAEFEPDHLLQDHVSRVASTVHHMARHPDATSRIDQTLGWIESQPDKRSIASSFRYGNGSLMLSQWNKMDMYAVFENRPVLVSTPFTSVSCIDGLGYFLPALDGGIDVCLSLSEPVWKYIDMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5M2</accession>
    <name>A0A1Y1U5M2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000025">
        <property type="protein sequence ID" value="ORX33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867677.1">
        <property type="nucleotide sequence ID" value="XM_022017320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5M2"/>
    <dbReference type="GeneID" id="33559129"/>
    <dbReference type="InParanoid" id="A0A1Y1U5M2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="170" mass="18871" checksum="62D452229FD666D3" modified="2017-08-30" version="1">MSSLERRKALENCVKFMQDPLKQARHAVRTCDATLSKVTREVHTAAATDTPRTKAFRTALTTNRLLRAAHGEYRQVVSEMSKETFQTFSAAATSHPHESSSAISPNPGESPPEIDDDGEAGNINDQRYVPGSSKISQVKKSLEHKREHARLRKAKSRSKAKSAGRLIFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5W3</accession>
    <name>A0A1Y1U5W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867753.1">
        <property type="nucleotide sequence ID" value="XM_022018754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5W3"/>
    <dbReference type="GeneID" id="33560563"/>
    <dbReference type="InParanoid" id="A0A1Y1U5W3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="249" mass="27683" checksum="E476831172A74960" modified="2017-08-30" version="1">MNIATQSTKSLDDLQSQFNLLKLSRSSFGPEPSQWPKTLAMGRYFLDNNKRNLLGDALKDTFTEYVPTLDSSTMFVSRNLNSNQEWFGNRVNEMSDDTFQAFCNTLNSNVLEKMHQLFEDKWAKEPENTSARPFKTQKSGTMQKKKRSPGDVKAAVVSWPDEADTDMQEVGSRSIGQGTDCDTLPLRTFGMPVVEPGGERSPVTHVRQMSIASILDDTARVHGDSRTVKLHHGPSIGTETGTGSKSLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6B6</accession>
    <name>A0A1Y1U6B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_610564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867899.1">
        <property type="nucleotide sequence ID" value="XM_022014204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6B6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6B6"/>
    <dbReference type="GeneID" id="33556012"/>
    <dbReference type="InParanoid" id="A0A1Y1U6B6"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000832">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="314"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="782"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="948"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1253" mass="134108" checksum="699E817204DBDB0A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6H1</accession>
    <name>A0A1Y1U6H1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867943.1">
        <property type="nucleotide sequence ID" value="XM_022017178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6H1"/>
    <dbReference type="GeneID" id="33558987"/>
    <dbReference type="InParanoid" id="A0A1Y1U6H1"/>
    <dbReference type="OrthoDB" id="2568061at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18729" checksum="D4FB8731C5BF1E27" modified="2017-08-30" version="1">MVGLASIKSPMMGLLLAVAYSNMVLDVIYIVKVHENQYTQTYPPAIAASLVRSILHMLYCLGYFVTSAKGVAYQAKNIAMAMLFFALFGVGADAAAIALKHNVNYCPVSASNYGNCIGVLRGTVGLGFALVGLDLIYIGYLAALVSKYGAWGKDLYNIPERKLANADLNDKAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7D6</accession>
    <name>A0A1Y1U7D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_183626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868227.1">
        <property type="nucleotide sequence ID" value="XM_022012119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7D6"/>
    <dbReference type="GeneID" id="33553927"/>
    <dbReference type="InParanoid" id="A0A1Y1U7D6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="49116" checksum="504EF83E7CCB4788" modified="2017-08-30" version="1">MNRDQPTPTSKGMRGTRTAIRDASLRSKSVISQLERTDLDPRKQDVCTSTARQLAKSDHYYGTEEDHIARRHRALRESHVRVLGATYPHKTLTTAQSDKPSRSSCLDFSDALMSFNDCTRRPSGPPLAIPILWTVSRRPIDDQDDDSEAMPDHASRMSPRSAYQTPRKATSRIQGCSPPSPASSNLVTPPTPRVDLPFNPQISPTPTTPTRRSNKHRAHSSLSSQETVLSPRKDQAGHTPKAHRRPRLHPSAAAASDFDLDIFTLRLLSPVSPKVLPSFFKGSDSRPERVMDDWGDDEEQLVAEFPLPPSRDDSAGPGASRGCRAVSRPASPVVETPDTLKPRRGELMRMTQCSILEDLWWDDESETRTVTADTPRTVASFASESTHWSAVSKHWTYVMVAAKSLSAAIQIDELSGIRSWLIVIAFSCKCDQRRVSCKLVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7I1</accession>
    <name>A0A1Y1U7I1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_610336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868277.1">
        <property type="nucleotide sequence ID" value="XM_022014197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7I1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7I1"/>
    <dbReference type="GeneID" id="33556005"/>
    <dbReference type="InParanoid" id="A0A1Y1U7I1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="465" mass="52246" checksum="E6C1B97BA63BF017" modified="2017-08-30" version="1">MPTSQHPPPARNISSDLWASSSSSSSSSSSDQYTSDSDVLPGPASRPNQAASKLTRAPLRSSRRYSIDRTPRYLKKSRACLRHALLCVWTIGRLDQQRELKGSLSKRSTTVHRPWTELSDCTVQLQNHIRDSRVLRNEQLVKCLDIFLASYSIHVSPSAHDRSYIRDRLTKAEARAVPGTQRHLEELQAKASKSELSSHHVEILAQCPPGILLTLVDCALPRDAEGAEILVFSGIPGSQLEDLDLMDRRMLHLFHIFGIDPTQIDEVRLQDCGAARLPTWIRGMANLSTLRLERTFLKGLPMWILEMEKLRWISSGCVFPSSSITLKGTMASFKRVCQIPRDLYVPVVTNVPNIRGPMSLAKMSTISALRQYEDDLDFWAVARALPPKFSAALLESWHCERCDKICLDDECGMLSCQLLVKAFDNSEDRGIWIKSRLCRLCRATLIGQAHHENLLVKLGIIVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U812</accession>
    <name>A0A1Y1U812_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_636917</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868447.1">
        <property type="nucleotide sequence ID" value="XM_022016950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U812"/>
    <dbReference type="FunCoup" id="A0A1Y1U812">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U812"/>
    <dbReference type="GeneID" id="33558759"/>
    <dbReference type="InParanoid" id="A0A1Y1U812"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="391" mass="42984" checksum="1C81F4B0629E7AA4" modified="2017-08-30" version="1">MSRLKTASSACLASARTVPSLNSHVRAHRDHRHASSSAGPSKGPKFDEVVFSGIQPSGIPHIGNYLGLFLPFLELQSSLPRSTPLYLSIVGLHAITLPRDPNILRQERMDMLAALLACGVDPERTCLFYQEDIPEHAELAWILNTLTPVGRLQRMTTWKSQIATRTSSSPDQITDLDLKLGLLAYPTLQSADIMLYKSTIVPVGEDQTQHLELARDTAEAFNRAYGDIFPLPQTRIVPSKRILSLRDPSAKMSKSAPLAASRIVLTDPPEAIRKAVKTAVTDSEPSIKFDPEGRPGVSNLLLIWSSLDPSGQTPEQLAEQAQKDGWGMAKLKDAVTDVVVERFGNIRAEYERIRQEKGWLSQIAGQGRAKAGEVAKKTMEEVRRAVGIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U826</accession>
    <name>A0A1Y1U826_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868467.1">
        <property type="nucleotide sequence ID" value="XM_022016962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U826"/>
    <dbReference type="STRING" id="4999.A0A1Y1U826"/>
    <dbReference type="GeneID" id="33558771"/>
    <dbReference type="InParanoid" id="A0A1Y1U826"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="554" mass="61193" checksum="4EF624114ADE0D79" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U886</accession>
    <name>A0A1Y1U886_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_683654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868506.1">
        <property type="nucleotide sequence ID" value="XM_022019195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U886"/>
    <dbReference type="GeneID" id="33561004"/>
    <dbReference type="InParanoid" id="A0A1Y1U886"/>
    <dbReference type="OrthoDB" id="2564973at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013390677" evidence="2">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="206" mass="22397" checksum="370647B8D2F9A116" modified="2017-08-30" version="1">MGFEGPFFIVSLSWRLLLESLWSDHKTCSWTLAEVISVSTSPIPLLPLPANIEYLSTYPAHRPPRPCRFTMPIKRSFSMTPSPAPSSASSESAAYSPSPKKIKKETLTSDTSSPTTPKTPKSNSTATKSSKTPKTSKTGSKAQENGTWTAEKRGIFIDEIIAAGYKGAELDSLADKLNLSKRQLIDQLVPNRNNLRGKAVKGAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8A4</accession>
    <name>A0A1Y1U8A4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_637220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868520.1">
        <property type="nucleotide sequence ID" value="XM_022016979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8A4"/>
    <dbReference type="FunCoup" id="A0A1Y1U8A4">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8A4"/>
    <dbReference type="GeneID" id="33558788"/>
    <dbReference type="InParanoid" id="A0A1Y1U8A4"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="354"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="684"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="880"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="967"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1174" mass="130029" checksum="48631DC0CD203513" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8J4</accession>
    <name>A0A1Y1U8J4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_635569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868623.1">
        <property type="nucleotide sequence ID" value="XM_022016819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8J4"/>
    <dbReference type="FunCoup" id="A0A1Y1U8J4">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8J4"/>
    <dbReference type="GeneID" id="33558628"/>
    <dbReference type="InParanoid" id="A0A1Y1U8J4"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="181"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="660"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="943" mass="106273" checksum="84ABE0A5F428E9E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8K4</accession>
    <name>A0A1Y1U8K4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_684270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867780.1">
        <property type="nucleotide sequence ID" value="XM_022019211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8K4"/>
    <dbReference type="GeneID" id="33561020"/>
    <dbReference type="InParanoid" id="A0A1Y1U8K4"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="875" mass="97870" checksum="628D8F925ADFF7D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8M9</accession>
    <name>A0A1Y1U8M9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_635692</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868663.1">
        <property type="nucleotide sequence ID" value="XM_022016833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8M9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8M9">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8M9"/>
    <dbReference type="GeneID" id="33558642"/>
    <dbReference type="InParanoid" id="A0A1Y1U8M9"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="79"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="492" mass="54056" checksum="D765DAE1127F9879" modified="2017-08-30" version="1">MCPHVPDQSNPNGEEMVPINTSSQPHIPPPVPAGTNGTQPNGHQSNGVDTNHHSAPPKVKSHKDMYGRASDFLSNTSNWKIIESTLREGEQFANAFFTLETKIKIAQMLDEFGVEYIELTSPAASPESRAHCEAICKLGLKRTKILTHIRCHMDDARLAVETGVDGVDVVIGTSSFLRDHSHGKDMTWITKTAIEVIEFVKSKGIEIRFSSEDSFRSELVDLLSIYRTVDKIGVNRVGVADTVGCADSRQVYDLVRTLRGVVSCDIETHFHNDTGCAIANAYAALEAGATHVDTSVLGIGERNGITPLGGLIARMMVADPEYVKSKYNLPMLREIENLVAEAVEISVPFNNYITGFCAFTHKAGIHAKAILANPSTYEILNPADFGMTRYVSIGHRLTGWNAVKSRVEQLNLNMTDEQIKDATAKIKELADVRTQSMEDVDMILRIYHTGIHSGDLKVGQSAVLDKLLQKHMPSREGSPTRDSPNKKVKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8X9</accession>
    <name>A0A1Y1U8X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_604681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868753.1">
        <property type="nucleotide sequence ID" value="XM_022013986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8X9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8X9">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8X9"/>
    <dbReference type="GeneID" id="33555794"/>
    <dbReference type="InParanoid" id="A0A1Y1U8X9"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="84"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="396"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="635" mass="69994" checksum="AB67321B2139E7EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U909</accession>
    <name>A0A1Y1U909_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-type lectin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_584223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868275.1">
        <property type="nucleotide sequence ID" value="XM_022013671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U909"/>
    <dbReference type="FunCoup" id="A0A1Y1U909">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U909"/>
    <dbReference type="GeneID" id="33555479"/>
    <dbReference type="InParanoid" id="A0A1Y1U909"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="155"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="280"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="483"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="661"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="833"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="916" mass="102816" checksum="7E21C349140E828F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAC7</accession>
    <name>A0A1Y1UAC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">14-3-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_633506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869204.1">
        <property type="nucleotide sequence ID" value="XM_022016630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAC7"/>
    <dbReference type="FunCoup" id="A0A1Y1UAC7">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAC7"/>
    <dbReference type="GeneID" id="33558439"/>
    <dbReference type="InParanoid" id="A0A1Y1UAC7"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="29142" checksum="129F6E062E6FEF68" modified="2017-08-30" version="1">MSNREDSVYLAKLAEQAERYEEMVENMKTVASADQELTVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKGNADQVSMIKAYREKIEGELAKICEDILQVLEKHLIPSAASGESKVFYHKMMGDYHRYLAEFATGDKRKDSADKSLEAYKAASDVAVTELPPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMTEGTGDDAPKREEESKAEEAPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAE3</accession>
    <name>A0A1Y1UAE3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868333.1">
        <property type="nucleotide sequence ID" value="XM_022017086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAE3"/>
    <dbReference type="GeneID" id="33558895"/>
    <dbReference type="InParanoid" id="A0A1Y1UAE3"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="36094" checksum="D797BDC9CB50C363" modified="2017-08-30" version="1">MFNALAGPARAASQVSLRPRIPISPFRALHASSSVLKKPSRKAVAVKEFDNDESDGDLFAVDTSTPVSTQATDDQDASAVSALNREIRESLWEIVKRGARPTDDARESRRAQLPIQRNILDSYIQACESRLDLESLRGLLRGWRVMGKRVTGTQAQQIIDKSIELNFPEIALELLNDKLAYGVNTVPDSAYFRLCHSLLEQEAPPSKLPTYLQSGRHSIALGNLVLFLRTRSRASDTSAISGDGVKKSPKTGVRLPASAPKSHEPLPHPITKDEVEFVNFALDTLHSAGGRWAEVAEQVLPRKRWDRHLVRREQVVAEKKAAAVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAM3</accession>
    <name>A0A1Y1UAM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_117143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869296.1">
        <property type="nucleotide sequence ID" value="XM_022011946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAM3"/>
    <dbReference type="GeneID" id="33553754"/>
    <dbReference type="InParanoid" id="A0A1Y1UAM3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="150" mass="16720" checksum="1ACE05D3F0FA2825" modified="2017-08-30" version="1">MSYGEAILRHLTRVDSSALRPVVDLIHPLSMNGHLFRPLWSSSSINSVAGPSRLSLTPARFLLPSFQSSTFASSASPSMVSRLFSTSTQMLHRAGMKRAAMQRFKYTKSTGTWKRTRGGHAHFNTKRPARFFHGLTPEVEVTRRSVVSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAT5</accession>
    <name>A0A1Y1UAT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_634040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869359.1">
        <property type="nucleotide sequence ID" value="XM_022016695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAT5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAT5"/>
    <dbReference type="GeneID" id="33558504"/>
    <dbReference type="InParanoid" id="A0A1Y1UAT5"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="268" mass="30247" checksum="EA0BE3A7E2348F15" modified="2017-08-30" version="1">MSSSSSARAHVQWDEERSEPYMIIPAVPSIRFTPLRSTDGQNFVDLYNDPEGGQYAFRRPYPYDLECSQWFMDNFHADLDMICASLKSHLEHGTRPPATTFPLAMMRYVPTCSSVNGSTATDSSYSKLDRPDVDQAVEDRLSEMNLSPDTFLGSFTSFPNTNDIANSIGETSKSASRTHMVAYDLMPFMRGKGVGTRALDAVLEGWNDWVGVEETIAHIQESNVASRTMIRRCGFDEVDSEIWQWPLEKGGGERRVFKYVRGRPKDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB13</accession>
    <name>A0A1Y1UB13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_130390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868976.1">
        <property type="nucleotide sequence ID" value="XM_022011985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB13"/>
    <dbReference type="GeneID" id="33553793"/>
    <dbReference type="InParanoid" id="A0A1Y1UB13"/>
    <dbReference type="OrthoDB" id="2563892at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30777" checksum="2E92BB08A14E21A0" modified="2017-08-30" version="1">MNEMPISIWQTHAKSGQNDSPPTTITWVTVHCDPAADVVLISCDLVYFRVSGHYLKRSSGFVRDLLSVPFRKRKRSLFGPERANSLPDTREDLGDAPVIELQARSATVRAYISLVYLNATAKIPKQFESILDRYLTCFDQVVEMIDIYRLMQSDDEKWDKKLKAKLYREVPNAPWQAFCYAAHLGDLTMARAAIRCFGRDPSCPPSRLPDVAHQAFADAPADSWWDVIRLRARASTGMTDYWHESRTMDWTEVAELFGPAEVRLQASSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB91</accession>
    <name>A0A1Y1UB91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_632139</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869462.1">
        <property type="nucleotide sequence ID" value="XM_022016493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB91"/>
    <dbReference type="FunCoup" id="A0A1Y1UB91">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB91"/>
    <dbReference type="GeneID" id="33558302"/>
    <dbReference type="InParanoid" id="A0A1Y1UB91"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="224"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="450"/>
            <end position="453"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="59651" checksum="3B3064F08FFD6757" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBF6</accession>
    <name>A0A1Y1UBF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">35S primary transcript processing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_632560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869563.1">
        <property type="nucleotide sequence ID" value="XM_022016531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBF6"/>
    <dbReference type="FunCoup" id="A0A1Y1UBF6">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBF6"/>
    <dbReference type="GeneID" id="33558340"/>
    <dbReference type="InParanoid" id="A0A1Y1UBF6"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
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    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="9">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="10">
        <location>
            <begin position="174"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="244" mass="27661" checksum="9F444FF474C3F20F" modified="2017-08-30" version="1">MIRQPGTQIKLTNVSIVRMKKGGKRFEIACYQNKVSEFRSGVETDLSEVLQIEQVFNNVPKGQVAKKEDWQKAFKTEDINKVIEEILRKGDLQINNLERTQNLQSLSREICTLVSEMTVDPETSRKHTVGMIEKSMSEVGFNVKADKPAKAQALELIKKLSSEESPLPVRRVRMRIRISMNSKDGKRCREKIMQDVEEVEEEDMGTEWEAIVQIDPSAFRTLTDLVNTETKGKGRVESMGSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBP2</accession>
    <name>A0A1Y1UBP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Voltage-dependent anion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_582051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869658.1">
        <property type="nucleotide sequence ID" value="XM_022013542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBP2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBP2"/>
    <dbReference type="GeneID" id="33555350"/>
    <dbReference type="InParanoid" id="A0A1Y1UBP2"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="404" mass="44632" checksum="83BF552543D199B1" modified="2017-08-30" version="1">MASLSPVSSTVTWRGPASRADIDLDALYLDGGKNESRDLPWRERLKHFTIPWYLLTMSTGGLAGLLASQPHAFRGLFTIGKTIFIFDLVLFIIITALQIHRFARWPHMFMTALKNPAEALFVPSLVLSLEGIISGTQAFGGPSTGTWLYVTVYVLFWIYVALAILCALAVYSYLFTARRLTVHSMTPAWLLPILACNLTGALAGSLAAGQTPFHRVPLLVAGLTLQGLGFWVSIPLLGVWITHLMSDGLPKAATRPGMFVAAAPAGYTAYALLHMANAIPLNESYFARHDHAKEMIKTMALIFSVFIWCMSFFLFLVALVAIVSATIDRQMSFHLTWYSFVFPNIGFTQATISIGQALDSQAVTWVATGMTLILVTVYIFVLLAHIRAVWKRQILWPGRDEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC45</accession>
    <name>A0A1Y1UC45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869753.1">
        <property type="nucleotide sequence ID" value="XM_022016363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC45"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC45"/>
    <dbReference type="GeneID" id="33558172"/>
    <dbReference type="InParanoid" id="A0A1Y1UC45"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="845" mass="93502" checksum="52ED2F089B81750D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCU3</accession>
    <name>A0A1Y1UCU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_682685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="FI21816P1"/>
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    </dbReference>
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        <property type="entry name" value="E set domains"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="849"/>
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        </source>
    </evidence>
    <sequence length="1866" mass="203185" checksum="CB296F6AB6EB33B1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDH3</accession>
    <name>A0A1Y1UDH3_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_630799</name>
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        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="48"/>
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        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX35597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="207" mass="23272" checksum="8F97312E539D2AE4" modified="2017-08-30" version="1">MSITRTATRSARPLQLFYTPLRTQSFNMSSTTAGQDTPTFGLKERQPSTEEKQLIDDVLQLYKLNPISSAYARYAENAKFHDPIGIAEGLNSIKAQFNSMPSIFSKSEVKGMKVLENPEVKPPSVQFALSQLYTFKAGNMDKLVNSKITLHVDPSTNQITQHDEEWDGKPNSTGEDGFFGKLNEMRKKFTANTVEKMADTRPKDQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDI1</accession>
    <name>A0A1Y1UDI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_677467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022018958.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="33560767"/>
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    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="423"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="563"/>
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        <location>
            <begin position="81"/>
            <end position="567"/>
        </location>
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            <begin position="1"/>
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        </location>
    </feature>
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            <end position="641"/>
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    </feature>
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            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="641" mass="69247" checksum="A81282247B1FA9C1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDP4</accession>
    <name>A0A1Y1UDP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_630400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="94"/>
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    </feature>
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            <end position="82"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="139" mass="15529" checksum="A17227379C7DC62F" modified="2017-08-30" version="1">MVQTSVAVERERRVYYAIPAIAHLRWKMIGGQKGCGGSRRDVLFLMTHAGGMISSTLSQLDTSHPPLSRSLPNPHTFNQPNTGDAPPPPPKRNRLSNLFKLSPEICCRRHTGHALCFSCCQLRIPDIALRQDSRDRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1UE05_9TREE</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name type="scientific">Kockovaella imperatae</name>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX36273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012912.1"/>
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    <dbReference type="OrthoDB" id="2563978at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="710"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="719" mass="75619" checksum="D8BF7DD424BF1C37" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC8</accession>
    <name>A0A1Y1UEC8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_581044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870512.1">
        <property type="nucleotide sequence ID" value="XM_022013480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEC8"/>
    <dbReference type="FunCoup" id="A0A1Y1UEC8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEC8"/>
    <dbReference type="GeneID" id="33555288"/>
    <dbReference type="InParanoid" id="A0A1Y1UEC8"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="371" mass="41302" checksum="90021CBDC07EF2B3" modified="2017-08-30" version="1">MIPRSHLAIILATLIAIFWLVGTSFWPKKSALETPARKTAFRQRLVAVGDLHGDLENAQKVLRMAKIIDQNANWIGGTDILVQTGDVVDRGTFAFDIYRMMQRLRGQAADAGGQLVSILGNHEIMNAIGDWRYVTDEDIKHCGSTAQRQKDMSIDGWLGQEWLANYSSTALVALADHPQAPRLSFTHGSLRPSYPNLTPYPGNINRLGHSLLTKALTPPMAMPYPPNPYPGLPRALTDAEAELYAEGGPFWWRGLAQSPDEKLVCGWAEQLKAKLGVRRIIGGHTPNFERIVDRCEASIIIIDTGISSAYGGVLSALEIIYTLSPTAPNRIHHQDPLLLTQGTEYVEREEVHAIYENRRRQLAVEERTIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UED0</accession>
    <name>A0A1Y1UED0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_494885</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870504.1">
        <property type="nucleotide sequence ID" value="XM_022012940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UED0"/>
    <dbReference type="FunCoup" id="A0A1Y1UED0">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UED0"/>
    <dbReference type="GeneID" id="33554748"/>
    <dbReference type="InParanoid" id="A0A1Y1UED0"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX36403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="140" mass="15067" checksum="296917AB97B4BBF2" modified="2017-08-30" version="1">MASTLNVESPIGASSSGDDKRITLDQLKEHTTRDSLWLLIHGKVYDVTKFRDEHPGGDEVLVEEAGHDATEAFDDIGHSPEADSIMEKILIGEFKGESKKKAAPAARATAGQTASTGGFPIWVIPAGFAVVYLAWRVFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEE9</accession>
    <name>A0A1Y1UEE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_628796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870524.1">
        <property type="nucleotide sequence ID" value="XM_022016145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEE9"/>
    <dbReference type="FunCoup" id="A0A1Y1UEE9">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEE9"/>
    <dbReference type="GeneID" id="33557954"/>
    <dbReference type="InParanoid" id="A0A1Y1UEE9"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="25381" checksum="871FCE8F4764A6B1" modified="2017-08-30" version="1">MSTLFSLKNNQSRTFKPKKVPEGSKQWQLKQYAQQTLGSGNLRKAVQLPEGEDSQEWIAVHVVDFFNHVNMLYGTISEFCTPSECPIMNAGPKYEYFWEDGETYKKPTHLSAPAYVEALMSWTQSILDDEKHFPQKIGVKFPSTFMTTAKTILRRLFRVYAHIYHSHFDQICALGIEAHLNTNYRHFLLFVDEFSLLSEKDLVPLEDFNKTILEETSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEW6</accession>
    <name>A0A1Y1UEW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_520673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870175.1">
        <property type="nucleotide sequence ID" value="XM_022012987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEW6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEW6"/>
    <dbReference type="GeneID" id="33554795"/>
    <dbReference type="InParanoid" id="A0A1Y1UEW6"/>
    <dbReference type="OrthoDB" id="2596744at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1045" mass="112180" checksum="87F1AB0C4C98FEB1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEZ5</accession>
    <name>A0A1Y1UEZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_651127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870710.1">
        <property type="nucleotide sequence ID" value="XM_022018273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEZ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEZ5"/>
    <dbReference type="GeneID" id="33560082"/>
    <dbReference type="InParanoid" id="A0A1Y1UEZ5"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33783" checksum="7A5F088986AEC033" modified="2017-08-30" version="1">MALKIGYVGLGALGSAIAPNVAAFAHENGLEPVVFWNRSENKFTAIKDQLNGGRYASDLADVVKDCNLVLACLANDQACEEVFGAMAEALKTSNSSEKVVFVNQSTIKPITANKLKDQIEEAGGSYLTGTVFGRPDAAKARKLVVALAGDKATKDKVKPLMEFIGRYTLDAGQDCANGAALKLMGNSIILGTMQLYSEAYALGDAIGMDPKVFHELHSTLFNSPVLLPYSDKISQGKFGHAGFTVENGLKDATYILSMGEELGHPVNLPTIERARNNLSTLKDEGLGHFDWSSIASTERKNAGLPPWREGTNDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL0</accession>
    <name>A0A1Y1UFL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_656613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870848.1">
        <property type="nucleotide sequence ID" value="XM_022018845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFL0"/>
    <dbReference type="GeneID" id="33560654"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL0"/>
    <dbReference type="OrthoDB" id="2574468at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="267" mass="28569" checksum="5CB99AF49C00BA83" modified="2017-08-30" version="1">MTQPLFFSGQPGLGSGSTLKPKRKYSGDEEEPELAQQQQQQTFSLPPFKRRNTVSDSYAVPELVPDHSNSASDDDIAMDQDQGMESLESPNEMDRDGCGIAMGRNYAYESGGSGGFGFGPGAEEDDVMEEASSGHSTNYPTVYPSLTPHPNPNHFSNLPPYTNSASFNTYTAPPENAVSFTVRPKSPLSAQAFSTTLAPPSRSAGLLQPTINAPLGPDATAIERVRAAHGPQCKSIPRLTVSPYPDPITGSQTMYSMCPDCGTIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL6</accession>
    <name>A0A1Y1UFL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_651544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870405.1">
        <property type="nucleotide sequence ID" value="XM_022018350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFL6"/>
    <dbReference type="GeneID" id="33560159"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="153" mass="17181" checksum="B3BE654049E99045" modified="2017-08-30" version="1">MSSTSGNKNITITKRNAQSVFDGMSLDRDLPQDTKNVIKYAMLKSDPLVMPHHFNKIIAKEVVGRHCEEKPPVGIFSPLIETSIKAGRLYRNGDQQARSCLTTEASEIYPMCQRLPEELVSTLVGEDHYDALIKHSKELAEDRSKGPNKRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFP5</accession>
    <name>A0A1Y1UFP5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_609010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870437.1">
        <property type="nucleotide sequence ID" value="XM_022014137.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFP5"/>
    <dbReference type="GeneID" id="33555945"/>
    <dbReference type="InParanoid" id="A0A1Y1UFP5"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="692"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="1163"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="1163"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="551"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1246"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1505"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1606"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="854"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="889"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1542"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1617"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1639"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1694" mass="178514" checksum="93BCED6B195CA4A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFT2</accession>
    <name>A0A1Y1UFT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_563186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870999.1">
        <property type="nucleotide sequence ID" value="XM_022013023.1"/>
    </dbReference>
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        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFT2"/>
    <dbReference type="GeneID" id="33554831"/>
    <dbReference type="InParanoid" id="A0A1Y1UFT2"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="88" mass="9900" checksum="DBD13307857D8F6D" modified="2017-08-30" version="1" fragment="single">STLRASLIPRITSLLRPTLSSPIPSALLPHNSPLDLGQVRFGSKGGNTYQPSQRKRKRKHGFLSRIKTAKGRKILTRRMVKGRKFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFU8</accession>
    <name>A0A1Y1UFU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secretory pathway protein Sec39-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_628730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870508.1">
        <property type="nucleotide sequence ID" value="XM_022016141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFU8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFU8"/>
    <dbReference type="GeneID" id="33557950"/>
    <dbReference type="InParanoid" id="A0A1Y1UFU8"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="259"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1100" mass="120093" checksum="395B58AD3441B369" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFV5</accession>
    <name>A0A1Y1UFV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871002.1">
        <property type="nucleotide sequence ID" value="XM_022018328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFV5"/>
    <dbReference type="GeneID" id="33560137"/>
    <dbReference type="InParanoid" id="A0A1Y1UFV5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="110" mass="11869" checksum="1F8D8B7142EC852E" modified="2017-08-30" version="1">MSSESSHEFDDQSWVEVGKKDYTETPPSEPENFVDAEERSGEENGTPSQTGDTEQSSSIAGSTIESDAEPPSVAETQKADELTDTQQGEADAVNGASETSKQRTYASFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG13</accession>
    <name>A0A1Y1UG13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_627856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871037.1">
        <property type="nucleotide sequence ID" value="XM_022016054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG13"/>
    <dbReference type="GeneID" id="33557863"/>
    <dbReference type="InParanoid" id="A0A1Y1UG13"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="526" mass="56268" checksum="48B5AA44A5B84CDF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGF2</accession>
    <name>A0A1Y1UGF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_526643</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870274.1">
        <property type="nucleotide sequence ID" value="XM_022012999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGF2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGF2"/>
    <dbReference type="GeneID" id="33554807"/>
    <dbReference type="InParanoid" id="A0A1Y1UGF2"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="170"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="286" mass="30985" checksum="5191F62EF03337E6" modified="2017-08-30" version="1">MVRSKVLLKDVKTVLFHAGAQTVARRTEPLPQLTCIGKACKVFQPEIVQCTNMGEDDTGSTQWRCDADMPNGFRFGKIEVSCEGWSKPGDRFITPGSCALEYNLYQSNPGLYDSSPSVPSSTERIIDKLFKVLFYAVTFVLLYTLFRSIFNRFFPRHSLPSLSSFFPPSDGPGHGHGHHHHGWGSGGPGPGFNPGPSGGGPPPPPYTKDPEASRGGGMGLWTGLAAGGLAGYLAGRSTGAQAPRPPAQVRQRPRRSLWEEDEDRGVGPSQPREMRRATGFGGTNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGK5</accession>
    <name>A0A1Y1UGK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_681078</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871196.1">
        <property type="nucleotide sequence ID" value="XM_022019106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGK5"/>
    <dbReference type="GeneID" id="33560915"/>
    <dbReference type="InParanoid" id="A0A1Y1UGK5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="66"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="539" mass="59805" checksum="A89F30AB6089FB8D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGY8</accession>
    <name>A0A1Y1UGY8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871358.1">
        <property type="nucleotide sequence ID" value="XM_022018232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGY8"/>
    <dbReference type="GeneID" id="33560041"/>
    <dbReference type="InParanoid" id="A0A1Y1UGY8"/>
    <dbReference type="OrthoDB" id="3261505at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="401" mass="42373" checksum="D725140F44312B5F" modified="2017-08-30" version="1">MTLAHPLSPGSDRHHIRILQARQLDSDSNSTIATTSSTSAQDQSSSVTSTSSASITVSDITSSISSSTTLSSVITTTSSTTSSIAASTPTTSSSTGDLDTLPSQNEVSAAEPTPSAVETTSSTIAVTSTSSAAPTTLNDFTRTVVHTNPASVSVKTMLSTAPGPAPTTQSDNAETNDNIGGLPRTTFIIIIVVASVLVLVALAWTAFRKWKLRPSRRFDSKMAPVDFSPNGLGGNDDFLEKTLHRSASSSSLDRQRQQFIADLDRDGPDYVEGVPQHDFTAGASGMQYDSNMYNHDPFAHSAAYDYDTSYYHQAHQPIAPLPPAAVAEYGSHDYPTQDPGEGYSDLHRGNSGSSHGSHHGSQGSGRQQAVRPSDFPTPGQYLGRPTEGDGPYAQASYYGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH80</accession>
    <name>A0A1Y1UH80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-finger domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_626072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871446.1">
        <property type="nucleotide sequence ID" value="XM_022015868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH80"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH80"/>
    <dbReference type="GeneID" id="33557677"/>
    <dbReference type="InParanoid" id="A0A1Y1UH80"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="147" mass="16194" checksum="DDA508E7B9634953" modified="2017-08-30" version="1">MASRLVQSSRTLARNLLWTISRRSVSSTPLPTAPEPVPEDQPDSSTPKLYQQSPNYPKTWSTSQNPKPHAYDNVRFEQVDLEFQPKPKSAMAMVAEDPIRLVSGRKAVCDGGGGPLGHPKIYINLDKPGPKVCGYCGIRFEKAHAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHC6</accession>
    <name>A0A1Y1UHC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_625966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871427.1">
        <property type="nucleotide sequence ID" value="XM_022015858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHC6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHC6"/>
    <dbReference type="GeneID" id="33557667"/>
    <dbReference type="InParanoid" id="A0A1Y1UHC6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="865"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1095"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="936"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1095"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1227" mass="135006" checksum="2EED8FCFCC934BCE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHK5</accession>
    <name>A0A1Y1UHK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_452149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870634.1">
        <property type="nucleotide sequence ID" value="XM_022012823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHK5"/>
    <dbReference type="GeneID" id="33554631"/>
    <dbReference type="InParanoid" id="A0A1Y1UHK5"/>
    <dbReference type="OrthoDB" id="3366194at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="206" mass="23039" checksum="AA2D272929F745AF" modified="2017-08-30" version="1">MTSAQVEKQSSKTKKPKADAQMTNIPSYGVDFFEHRRKLWLAGKAYPQPTSSELPLTYTVTAMDPQPKSFVKSISRETPSIQRLDRLLQNERAIGDKSTWDNGVSRVWSMLDCGRHLSTPIPLNLVIKVLRCSWVRDGTWTIDPVTKRPAVPPESPPLPSDIVPIPQLDPLLKSKHKGQLRLSSPTKWKNGPVIDEEGSEMVSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHZ3</accession>
    <name>A0A1Y1UHZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative guanine aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_624823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871144.1">
        <property type="nucleotide sequence ID" value="XM_022015736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHZ3"/>
    <dbReference type="FunCoup" id="A0A1Y1UHZ3">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHZ3"/>
    <dbReference type="GeneID" id="33557545"/>
    <dbReference type="InParanoid" id="A0A1Y1UHZ3"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="68"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="481" mass="53209" checksum="44AAA48244F96AAB" modified="2017-08-30" version="1">MQAFVGTLVDTPELGQVRIRRDHVLVVNEQGYITSIFPSSTDDDAATKALASIPEDRITRLNGAGESFLLPTFVDLHQHAPQYLFCGTGLDLPLLEWLDRYAYRAEESIDADPALAKQVYTRLAQRYKEVGTGCTVLFGTIKVESNMILAKAFQEAGVRAFVGKLSMDQSPRPTYNEASTAASLESVTSFLDQFDAFVSPLPSHHRLVQPIITPRFVPTCSDALLCGLAKIADERNVRVQSHLCEGRDQMDWVERTRGKKDEEVFDEAGLLRPGSIQAHVTYLSPSLMELCKARGVTVAHCPLSNVYFSEAQFPLREALDAQVSVGLGSDVAGGYSLSIETNMRSAVYTSRMREGARQEEHHQRRAIESTANTTEKSTVSLSRTAGKGLSVSWVESLYIGTRGGKKALGMGGAFEEGMEFDAQLITLRDETSPLGVDQLDFFLPPSEGSEDAWWLEAVERWWCNGTRVNRRGMWIQGDKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI27</accession>
    <name>A0A1Y1UI27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871172.1">
        <property type="nucleotide sequence ID" value="XM_022015749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI27"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI27"/>
    <dbReference type="GeneID" id="33557558"/>
    <dbReference type="InParanoid" id="A0A1Y1UI27"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="412" mass="43208" checksum="D43977E08E89F866" modified="2017-08-30" version="1">MQGYYQQPMGGGSMMPGMMPGGGGMMSGMQAMPGTGGMGGMPGMGGMGGGGPMMGQMGMMGQPGQYWRSGIPQDYQLPQLGYNPDSSWSAWELANARYSGDRLQRGFFDQILSGLSDFFGARHLNQQAARDAHYRVYYSNEGTDSGNKTLGGAAAYQAFLFWDKEHHSLYHSYPSNENRERLVGLAVAELFSLWDRVQPRSSRANPNTAAEYAAATAKHLYDRHYDLSGGHYGRHSGYGADDDSDDESEGRRMKRRRYGGPMGMGSGGGMIPPAGMGMPNPGMGGFGMPGSMGNGMGGPMGMGMGSMGGPMMGGGMGGGMMPGLGTMGMGGMSGMGGMGGMGGMGMGQGMMIPGGYANPMNESQAAPGMHPYTYGSQSGVAYGNQPIDQMGQPTFPGGPGRSFYGYGQPRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI91</accession>
    <name>A0A1Y1UI91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_623314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871770.1">
        <property type="nucleotide sequence ID" value="XM_022015565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI91"/>
    <dbReference type="FunCoup" id="A0A1Y1UI91">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI91"/>
    <dbReference type="GeneID" id="33557374"/>
    <dbReference type="InParanoid" id="A0A1Y1UI91"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00443">
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
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            <begin position="39"/>
            <end position="529"/>
        </location>
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            <begin position="74"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="199"/>
            <end position="269"/>
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            <begin position="583"/>
            <end position="779"/>
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            <end position="96"/>
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            <end position="119"/>
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            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ORX37783.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="779" mass="84758" checksum="2591F91237156934" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIE4</accession>
    <name>A0A1Y1UIE4_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BD324DRAFT_680664</name>
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    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
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            <taxon>Cuniculitremaceae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
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                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Tremellomycetes</taxon>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
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                <person name="Bowen B.P."/>
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                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
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                <person name="Daum C."/>
                <person name="Northen T.R."/>
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                <person name="Spatafora J.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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            <dbReference type="EMBL" id="ORX37829.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIX3</accession>
    <name>A0A1Y1UIX3_9TREE</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD324DRAFT_651038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Kockovaella</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX37444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871482.1">
        <property type="nucleotide sequence ID" value="XM_022018255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIX3"/>
    <dbReference type="GeneID" id="33560064"/>
    <dbReference type="InParanoid" id="A0A1Y1UIX3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="148" mass="15844" checksum="5540A204B49AE426" modified="2017-08-30" version="1">MFFAPSFDLHSNGLPSSSFTIHAPVRPPSLLRAHQDHSQPAIASSNARPATAVVPIPHFAAMAIFNSRTDLQPAPLIPDESPVPYRSRESSLIAVTPQHQPSNGANPTPIYIPQTTARPSTHLSLPDHSPPAYFTSSPPKSSEQVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ31</accession>
    <name>A0A1Y1UJ31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="6">6.3.3.1</ecNumber>
            <ecNumber evidence="7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BD324DRAFT_681047</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="6"/>
    <dbReference type="EC" id="6.3.4.13" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871153.1">
        <property type="nucleotide sequence ID" value="XM_022019105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ31"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ31">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ31"/>
    <dbReference type="GeneID" id="33560914"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ31"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000011">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 26" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="128"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ORX37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="819" mass="86080" checksum="C0758F6BF516F5B6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ56</accession>
    <name>A0A1Y1UJ56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_428533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871183.1">
        <property type="nucleotide sequence ID" value="XM_022012761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ56"/>
    <dbReference type="GeneID" id="33554569"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ56"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="274" mass="29529" checksum="D917FD92D68CC658" modified="2017-08-30" version="1">MWEPKFNMLSSHPDNMASTTSYPIARTVNLEGQDSQASTDSRRLIWRSQGLATNAPGTYIPDDSGPRYVPEIQAYSGAFFPLPSQGGAQENPFIKPGEYASALRPEPSLGRTLLASSNTGSRSQASTVPSSNDSPGSPVPSFNTGRVLVQMETPGRQAASAPEHIGIPSRVASIPPPYITPVVGDHDLHDDYKFDNLERQPSNGSTLLSRTRWNSAANGPRSACVEPSSPGGSSTWQKMSREGAKPESVRQFKASEVSKSSRLAKQKVWASDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJC4</accession>
    <name>A0A1Y1UJC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_607752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872085.1">
        <property type="nucleotide sequence ID" value="XM_022014082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJC4"/>
    <dbReference type="GeneID" id="33555890"/>
    <dbReference type="InParanoid" id="A0A1Y1UJC4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="541" mass="59938" checksum="4501A5E949EBBE77" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJG2</accession>
    <name>A0A1Y1UJG2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872122.1">
        <property type="nucleotide sequence ID" value="XM_022015232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJG2"/>
    <dbReference type="GeneID" id="33557040"/>
    <dbReference type="InParanoid" id="A0A1Y1UJG2"/>
    <dbReference type="OrthoDB" id="2565179at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="645" mass="72710" checksum="CCB20021A6EA8826" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJN4</accession>
    <name>A0A1Y1UJN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron permease FTR1/Fip1/EfeU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_625738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871373.1">
        <property type="nucleotide sequence ID" value="XM_022015831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJN4"/>
    <dbReference type="FunCoup" id="A0A1Y1UJN4">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJN4"/>
    <dbReference type="GeneID" id="33557640"/>
    <dbReference type="InParanoid" id="A0A1Y1UJN4"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="419" mass="45540" checksum="89367D3B24A9168C" modified="2017-08-30" version="1">MGQDLFSVPIFFIVLRETIEAAIIVSVLLSFVEQLMRTGRLDGSSPSPSSTGSGSAESLDDIKRTQKLIKRMRIQIWAGTLTGFFIALSIGAGFIAVFYTKVTDLWGKTEELWEGTFSIIACILIYIMGIAFLKMDRSRVKWRIKLADAFEKSHSRAISAQNGASLSETEEARRGEGKSGKWALFILPFITVLREGLEAVVFVGGVSLNQPGKSIPIPAIVGLLAGGLIGYFIYRTGSTSTLHWFLIGSTTILFLIGAGLASKGVGLFEYYVFARGVGGDVAETGDGPGSFQVKGNVWHLTYGSPEPGSPGTNGGYQLFNAVLGWTNTATLGSILSYVFYWLLIIVTLIYLKWKEGRFAFFGYASKAGQNRLNGQTGSGDRKGYRTTVSPSDAEMEDLDQKKDVGESPGTEDRIPILEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJR8</accession>
    <name>A0A1Y1UJR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_348622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872232.1">
        <property type="nucleotide sequence ID" value="XM_022012546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJR8"/>
    <dbReference type="FunCoup" id="A0A1Y1UJR8">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJR8"/>
    <dbReference type="GeneID" id="33554354"/>
    <dbReference type="InParanoid" id="A0A1Y1UJR8"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012847278" description="Putative phospholipase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="435" mass="48304" checksum="BB9F2A9EB33FCF98" modified="2017-08-30" version="1">MLGTSITVIVIVIATMSMLRSPLFTGNLPQATPGPHKKIGYAYVRGPPTKAYSIFWPKLASTERPVLSMDQIGYSLFYPYGESAKKTHGVHWFPEPVNEMVFGYEKFLGKKVKALRFIVGRLKFPAYHNTPLKTNSSKYPLAVFSHGLAGTRHTYTQYVTSLASEGYIVLVVEHRDGSGPAVTLPDDEILHYVKQDDLVWDESNHGTLEKFRTSQLDFRIREIYECLHSFRQLVDGNSDKKDILGLDESARGEWIESFRDRIETDQLYLTGHSFGGGTILYTLQTPPPEGHASLPVKKAIMLDPWLEPLPIPSPSGHAPPHTPPTLVINSPGFTIWKGHFPRLVNIVKGMGGNLVTLMNSNHQSFSDFPLLAPTSPSKALQLLSTVHELSASFLSGKLDQCPLVQAQPDEGDFERGEDGKMKADDPVVVHLKGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKI0</accession>
    <name>A0A1Y1UKI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_641671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872492.1">
        <property type="nucleotide sequence ID" value="XM_022017435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKI0"/>
    <dbReference type="FunCoup" id="A0A1Y1UKI0">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKI0"/>
    <dbReference type="GeneID" id="33559244"/>
    <dbReference type="InParanoid" id="A0A1Y1UKI0"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="308" mass="34012" checksum="6B89A1CBBF313799" modified="2017-08-30" version="1">MPSSAAPPVLYTFTDPSQLQSSLANFILKAQTDAIAKRGQFTIALSGGSLPNNLKPLTSLEGIEWSKWQVFFADERIVPLDHPDSNYLACSKAFLEGVPIKREQIHTINTELFLDSTRTDPTAEPSDKDKSENEAVDIADDYEKQLVATFAGANTARYPTFDLILLGMGPDGHTCSLFPNHEVLSEGDRWVAEVLDSPKPPSRRITFTYPVLNHAQRCAFVATGEGKQDMLSQILDTPEEGLPCSRVRPASPGLVFWFVDQAAAAKVKFPNTEYKWIEEDVIADVDDPVAEERKKLKEEMDAAVKAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKI4</accession>
    <name>A0A1Y1UKI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_622687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871622.1">
        <property type="nucleotide sequence ID" value="XM_022015501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKI4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKI4"/>
    <dbReference type="GeneID" id="33557310"/>
    <dbReference type="InParanoid" id="A0A1Y1UKI4"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="408"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="556"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="89817" checksum="EF7FBA9AC40CD5F3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKU0</accession>
    <name>A0A1Y1UKU0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_621513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872514.1">
        <property type="nucleotide sequence ID" value="XM_022015387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKU0"/>
    <dbReference type="GeneID" id="33557196"/>
    <dbReference type="InParanoid" id="A0A1Y1UKU0"/>
    <dbReference type="OrthoDB" id="2563736at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="38170" checksum="6F3D8D5FBBFF288E" modified="2017-08-30" version="1">MEFKAGSTTPPPKNLYPCLATINITPTPVDRSRRFSGASQEPDDGNALRRVISGNRRKTSFGEAVVSTSADERRKSIEASKLSGGSAAGGKDEVTGRWFWRVQAGTNDTHLILLPLSQPPNPLLTVAPQPLSQAMPAHSATASKAKTSMPGGANEGHNRKANADADESLTTKFKNLFKKGSPKSDPQALPQDHVDTEPPGAHDSAEISHGASGTCDASSNVYSMTSTAVDDRILDQNGRGQQMPTAEANQLGATNANANAETEWPGMIKGDRLGAVVVDLRSVDKSKVVLGGGKKGEGSWVTVPINSHFLTLVHPMLEPIGKSHHDFPKSGSIRFDFDKDWIGAKGYVRLCQGSQLGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULF7</accession>
    <name>A0A1Y1ULF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_620497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872266.1">
        <property type="nucleotide sequence ID" value="XM_022015291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULF7"/>
    <dbReference type="FunCoup" id="A0A1Y1ULF7">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULF7"/>
    <dbReference type="GeneID" id="33557099"/>
    <dbReference type="InParanoid" id="A0A1Y1ULF7"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
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            <position position="18"/>
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            <begin position="17"/>
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            <begin position="18"/>
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        <ligand>
            <name>IMP</name>
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            <name>Mg(2+)</name>
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            <name>IMP</name>
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            <note>ligand shared between dimeric partners</note>
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            <name>GTP</name>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="46584" checksum="69260B91C0ED462B" modified="2017-08-30" version="1">MAQAPEGVTVVLGAQWGDEGKGKLVDILAQEADVCARCAGGNNAGHTIVVKNAKGEKTTYAFNLLPSGLVNEKCTAFIGSGVVVHIPSLFNELDTLERKGLKCADRLFISDRAHLVLGFHQIVDGLKEIELGGSSIGTTKKGIGPAYSSKASRSGLRVHHLYDPSFPAKFRKLVEGRFKRYGHFEFDTEGEIEMYLAFADRLRPHIVDGVQFMHKALTSGKRVLVEGANALMLDIDYGTYPYVTSSATSIGGVCTGLGIPPQAIKKVVGVIKAYTTRVGGGPFPTEDLGSIGETLQEVGAEFGVVTGRRRRCGWLDLVVMKYSTIVNGYTSLNLTKLDVLDGFEQIKVAVGYKIDGAEIEGFPADLERLAQVEVVYETLPGWKSDISKCTTFDSLPSQAQSYVRFIENYLGVKIQYIGVGPSRDSSIQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULP8</accession>
    <name>A0A1Y1ULP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_649018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872782.1">
        <property type="nucleotide sequence ID" value="XM_022017921.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1ULP8"/>
    <dbReference type="GeneID" id="33559730"/>
    <dbReference type="InParanoid" id="A0A1Y1ULP8"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="154"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="868"/>
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        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="897"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX38919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="915" mass="99048" checksum="3F428E071861E97C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULR4</accession>
    <name>A0A1Y1ULR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_618123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872851.1">
        <property type="nucleotide sequence ID" value="XM_022014992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULR4"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULR4"/>
    <dbReference type="GeneID" id="33556800"/>
    <dbReference type="InParanoid" id="A0A1Y1ULR4"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="257" mass="27655" checksum="3011A31C94D3CBD4" modified="2017-08-30" version="1">MSIAEQEPRSRIALVTGSSSGIGRSSAIALNAAGWTVILTGRRKDALEETVRLMGDDRSERTTIVVGDLAKPEFVEALFDIIRRDFGRLDLLFNNAGMGAPKQSFDRIPLDTFQEVLDLNVTSAFFCAQEAFKLMREQEPQGGRIINNGSISAYAPRPLGAAYTISKHAISGLTKSIALEGREHNIACSQIDIGNAYTSLSSSGSGQLQADGTTRVEAGFDVKHVGDALVYMAELPLEVNILSQTIMATTMPFVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULT4</accession>
    <name>A0A1Y1ULT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase C13 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_577299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872883.1">
        <property type="nucleotide sequence ID" value="XM_022013250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULT4"/>
    <dbReference type="FunCoup" id="A0A1Y1ULT4">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULT4"/>
    <dbReference type="GeneID" id="33555058"/>
    <dbReference type="InParanoid" id="A0A1Y1ULT4"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000016">
        <property type="entry name" value="GPI-anchor transamidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028168610" evidence="8">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="393" mass="43780" checksum="C0818FBF3C8F9956" modified="2017-08-30" version="1">MKLLLYSLLLSAVASLATFASAQKTVTAVHNGDVGKHTNNWAILVDTSRYWFNYRHMANTLAMYRTIKRLGIPDSNIILMLADDVACNPRNPLPGKVYANAGRHLDLYGEGIEVDYRGYEVTVESFLRLLTGRHPDHTPRSKRLLSDSSSNVFIYMTGHGGVEFLKFQDNEEISAFDVADAIEQMSEKKRFNKLLFMTDTCQAATMYSKIYSPNVISTACSQIGENSYSHHNDMEIGCAVIDAYTHHVLNYLETINKTSKQTLQDLFDDYDPVKMLSNPGISTELSDVPPAEILVTDFFGGVASVEMTVPSLVIEFADDIKWPEAKKRAPRHAELDRTPYRRARPSTPQSLRPTNLDTSIMKGGNTSPLAIVFPILISIGVLTLTARTIMSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMC0</accession>
    <name>A0A1Y1UMC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_375833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872589.1">
        <property type="nucleotide sequence ID" value="XM_022012619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMC0"/>
    <dbReference type="GeneID" id="33554427"/>
    <dbReference type="InParanoid" id="A0A1Y1UMC0"/>
    <dbReference type="OrthoDB" id="2575502at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="496" mass="54884" checksum="DE6B9331FDC11C1D" modified="2017-08-30" version="1">MRNYLKMLFKSSPESKSQTRPSRGGPLPPGVCLSPIGTTPQLQNSELEAIASRLRAHLSAEHESCDRTDETMARLLDALDDRLRVEQVTQYDPSSQNRQEVDGKGKQVETGQLAGASQACNGCLDTAQRLLQSRKGDQSSNEDLISRIIDLLKAQKAELVDIKLYSSDVELPTLATLRDIYLKAESGLRKLSSSRKNSESTDKLEGFVQVLSEGPDYLIDIALIEAIIRYVEVVDLSCGVEIRSELDRAIADHGSPQSFGQAAEMIVTLSSTLNSKVGNEAPTEDALRAITTLTRQLQRRVAPSTFNSRAHTPRTPSVVSDPNPASPADSRQSATSHSSSSDPDVRIYQNLDANELEARFGTGHIPTVRPKPNVPATPRRASQESDPSGESEPEVWEYRGNLLTRSALDLVMRQERLAFADSSGQYAGEISWDDLRNAWIPAWAEKLRPEDLADGEVPNTNPAEFVQKKEDAWANKIGWRDGQMYYHEEPKFTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMM4</accession>
    <name>A0A1Y1UMM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_619226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873174.1">
        <property type="nucleotide sequence ID" value="XM_022015145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMM4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMM4"/>
    <dbReference type="GeneID" id="33556953"/>
    <dbReference type="InParanoid" id="A0A1Y1UMM4"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="110"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="467" mass="50630" checksum="6E8C78E96ADB4E7E" modified="2017-08-30" version="1">MAIDQGLLTVDGTKHSANGSIGTNGTEDDVIGGDGMYFLTESAKTSSEDGIRALWKYEKPGVVSFVGCLAGRPNSDSFPFESITLNLKPPLGSTSTSTQNLSLNGADLADALQYGPSGGLPKLRSLLYQLQQEVHHREDDGTWGTTVGAGCQNLLNAAVDALMNEGDSILIETPVYPGILAPLRKKNAEMIEVDVDEGGLSPAALEQVMSSLTPDQKRPKLLYVNPIGCNPSGCSHSLERRLEVLKLCKKYGLLILEDDPYYYLAETTIPSYFELEKRVFPQGGRVVRFDSFSKLLSAGLRLGFATGPGNILRAIDTINSGTILHASTVSQGITYCLLEHWGLDGFRNHAHHVAELYARRRETFETIVKKHLSGLATWVSPVAGMFLWMDLSPSGIEDSFDFVLNAAKVHGVLGVPGASFYPNKRISSYMRLSFSVIDLDTDAEEGIARFAAAIKDKQKELGIKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMN1</accession>
    <name>A0A1Y1UMN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_655932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872666.1">
        <property type="nucleotide sequence ID" value="XM_022018831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMN1"/>
    <dbReference type="GeneID" id="33560640"/>
    <dbReference type="InParanoid" id="A0A1Y1UMN1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013208787" evidence="2">
        <location>
            <begin position="17"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="423" mass="45268" checksum="C5C35ABF52AB72AB" modified="2017-08-30" version="1">MLFLLISLVGLKSINAANCCGNIGAYDANTLWNLRADMCNNVLSHDSNSDGGREDATFWQNGNLRIEYAFEAYDTTNQFANCWSATQDLIQQCALNGNGAGSWVDGSESYYFSASAGNYGKRDATNSTTDPESLPPLPQASGSIDELQLQSGSYNINGMVANLQIQGVVLNGSSATLLSKRDDVYNSTQGPGVNLTQTYSQSVNLTAFIIQSVQAAIQQQAATQTSGQNGTQGSRKRAQECSVSADDYVLVDGGYWQKPWTLASGCLYCGAGNSCNQKTATALTYGWSFSVGLSGSAQGEVAQAAIDVGFSFSRSVTTSTAIQCDWTEGTCHTYWIQQPMTWTRGFHINTQYEGGSQYAVTLQLVHGDAPNDDGLSVGCGSGCCADGASAVCGNPSFCQWARQDNDVEWYGVCNNWDQRPPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN56</accession>
    <name>A0A1Y1UN56_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_617965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872810.1">
        <property type="nucleotide sequence ID" value="XM_022014975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN56"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN56"/>
    <dbReference type="GeneID" id="33556783"/>
    <dbReference type="InParanoid" id="A0A1Y1UN56"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="706" mass="81249" checksum="40E279FEE8334F26" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNA4</accession>
    <name>A0A1Y1UNA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_575936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873325.1">
        <property type="nucleotide sequence ID" value="XM_022013158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNA4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNA4"/>
    <dbReference type="GeneID" id="33554966"/>
    <dbReference type="InParanoid" id="A0A1Y1UNA4"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="498" mass="55172" checksum="097C2067CB59CB44" modified="2017-08-30" version="1">MGAEQEVECVEDKRPIPPDDDELAAIDIVSPSEEVEKAKERRLLWKLDAVILPMTVLLYLSANLDRGNIGNARLQGLQKELLDNKDERYSVVLLSFYITYMLGSIPGTLLSKAIPPNYAIGSGCLIWYSFRAVAASAMAGVRSYAGIIVCRLFIGLGESIFGQAVVLHYSLWYKKDEIATRLALFIGAGVLAGAFGGLIAFGVSHIQSSIETWRILFLIEGIPSIVLGICVILFLPGRPDRSWLLTEEQKALQFRRLRSQNLDEGDDGIDWNGVKRAFTDWKAYVVTFIYSCMQLTLSSLSGFFPTIIKSLGYTNTQAQLFTVPPYAVAFGIMALLNSASDRVRIRGLFIMGAFTINAVGWLILLTVVHNLHVRYFACFCIVTGGYCTIPLIQSWVANNTGSQSQRAVQLGFLNSLANWAALTSPFIFPSKDNPRWPLGFGMNLAFSFAAILTAAFMTVWYRMENQRRDRNEGGPPLSGSKVEQAKLHDLAPGFRYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNH1</accession>
    <name>A0A1Y1UNH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_649160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872930.1">
        <property type="nucleotide sequence ID" value="XM_022017942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNH1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNH1"/>
    <dbReference type="GeneID" id="33559751"/>
    <dbReference type="InParanoid" id="A0A1Y1UNH1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="363"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="469" mass="50928" checksum="A8FE46C83D96C24C" modified="2017-08-30" version="1">MLNAAKTVLNRAAVMKDPTLARQMSSQPRKPVLIIGAGLGGLVLAHGLRRRNIPFELYERDVADSSRAQGYRITLQGKGPTALETCLPDSTMQSVLQRSGQPFKAMPDGAIVDALSGEKVGSMFEIKVPGGGQLGKGKGGPGSGPGGGKIGPTSFQANDTSQNDAGTSSRLPMRYHFQVDRRELRNDLLKDLPSPHYAKAFERYTATADGVIAHFSDGSSSTEGSLLVGANGVHSRVARQLIGEASIPLDTGVRLVYGKTPLTSDLLEQLSDNIRQGPKLIKDARDPHHQVFLLKDNMEFSHQESPNPYVFWSLIGDNVSFNVPDDKLFAMSPEEVSELTLKISSEWKDSLRVILKEQSTSETAVMRMTTSDPMRLPNWSTDRHVTLLGDALHCMPPTGGQGANSAMGDGMDLAERLSSGERDGEGWTEEVIRAYEQEMKATVGPMVKIGYARAVAWFGMKPMEGFRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNI4</accession>
    <name>A0A1Y1UNI4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_621930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872607.1">
        <property type="nucleotide sequence ID" value="XM_022015424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNI4"/>
    <dbReference type="GeneID" id="33557233"/>
    <dbReference type="InParanoid" id="A0A1Y1UNI4"/>
    <dbReference type="OrthoDB" id="2588346at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="292" mass="33309" checksum="627E8CA1803BF058" modified="2017-08-30" version="1">MSGLSLVMSILPLPLEMMPFYYLFSRLSMVAVVCLVCHCSIIWYGYNQAIEQMPKKTESATEAYKNLMKRKSERPDMWAHTRSHPSAFLTTRLAPPRIFPFPLGKSRPEATVRDELWWEGGNAPHVGHFNRPKLPEPEALNEDVVWARVKENMEREKQQKIWKKRIRTIQYLCVVIIVAFINSNVAIAGLCYLIYTTVSSELEDMLKPPPNMDIYHEYIDRITAPLKNQGAPKPGKDQPVGGMSYIYDPTEARGLKPTNTAIPINVVPPHVLMTSENHFYAGPGEQIKDPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNN9</accession>
    <name>A0A1Y1UNN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_311338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872977.1">
        <property type="nucleotide sequence ID" value="XM_022012456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNN9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNN9"/>
    <dbReference type="GeneID" id="33554264"/>
    <dbReference type="InParanoid" id="A0A1Y1UNN9"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="209" mass="22718" checksum="271E1D11C5BF700F" modified="2017-08-30" version="1">MSLSIIAVDDFDPLIGYSNYDDWSTPDPQDHPTWWNATSDVTGVPWYEATYHYTTVKGATVYFNFTGSSLAIYGASGPDTANYTIKIDPDLPQPFSQSYSTSNATGNGRTLLYSTDQLAYAAHQVQIINDGSGLLLDMIEFGVELAAEGTTTRAYSIRQTGPSRADQTSPAVHPIIRKAQATRGPTHLRAPRSGSLEIKSTITDSTPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP30</accession>
    <name>A0A1Y1UP30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_597277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873537.1">
        <property type="nucleotide sequence ID" value="XM_022013878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP30"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP30"/>
    <dbReference type="GeneID" id="33555686"/>
    <dbReference type="InParanoid" id="A0A1Y1UP30"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="548" mass="60749" checksum="E18DE779515D3BCD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP76</accession>
    <name>A0A1Y1UP76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_298033</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872788.1">
        <property type="nucleotide sequence ID" value="XM_022012419.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UP76">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP76"/>
    <dbReference type="GeneID" id="33554227"/>
    <dbReference type="InParanoid" id="A0A1Y1UP76"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000028">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1985"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="14">
        <location>
            <begin position="2330"/>
            <end position="2362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX38925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2362" mass="267584" checksum="A1BC09998887117A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP82</accession>
    <name>A0A1Y1UP82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873645.1">
        <property type="nucleotide sequence ID" value="XM_022017847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP82"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP82"/>
    <dbReference type="GeneID" id="33559656"/>
    <dbReference type="InParanoid" id="A0A1Y1UP82"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="739"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="840"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1055" mass="111229" checksum="B3A8A895D1AFE9E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPD4</accession>
    <name>A0A1Y1UPD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_615428</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873683.1">
        <property type="nucleotide sequence ID" value="XM_022014718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPD4"/>
    <dbReference type="FunCoup" id="A0A1Y1UPD4">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPD4"/>
    <dbReference type="GeneID" id="33556526"/>
    <dbReference type="InParanoid" id="A0A1Y1UPD4"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="60"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="248"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="391" mass="42328" checksum="9677235E7C2DE88C" modified="2017-08-30" version="1">MPPTESSPLLTSERQSSARRIHFFSSSKHLVFGSWLNLLIVAVPLCIVADVLKWPAAARFSTSFLAIVPLAKLLGDATEQLSMECGQTLGGLLNATFGNAVELIVAIAALLQNELRLVQTSLLGSVLSNLLLVLGMSFFASGFYYHESTFQMTAAQASSSLMTLACITLILPAAYHASETGNLSFVEDSTESGTSHGLLILSRGTAIILLLTYIGYLIFQLRTHSQLFEAEDSGEEETPAMDMWSAGIWLLIITVITAFCADILVGSIDETAQAWHIPKRFIGLILLPLVGNAAEHVTSVWMATKNKMELVIGVSVGSSIQIAAGMIPLLVIIAWPLNKELTLFFANFETIVLFVSVMLVNLLLQDGRSNYMEGMMLLSLYGVIALSYVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPI2</accession>
    <name>A0A1Y1UPI2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873667.1">
        <property type="nucleotide sequence ID" value="XM_022014713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPI2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPI2"/>
    <dbReference type="GeneID" id="33556521"/>
    <dbReference type="InParanoid" id="A0A1Y1UPI2"/>
    <dbReference type="OrthoDB" id="2593364at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="441" mass="48677" checksum="F3BF4B2E427FA0AF" modified="2017-08-30" version="1">MAVHLPAPMNKILSLRLPPDFKESEENTLGHVFKQDTLTWEALVKLLHIFCENLLVPCSYPNPMPPLERFDHPVPSLSSHYPPHVIYTFCVAIYNLMRRIQPEEHLDTGSTTRWGLMQKTPQGEYFSSPADLRVEDAMSRRLNIGTTVLETLAARGDSFGSAMPMTVQSTLASASRPTRTLSESLVRKASLKMGEWKQKRATGGFGSIVRGVTPIVNGWTPSFAPTYDSVHTVGLGFTSTIDAAYERAWHRRWACPEPPANTGWWGSTEEQIESVDQSLEDNSSLIEELQEWQAYRVRANLNSPTERELLAADQLLNSLAKLAGQTTPVELAGRINAHKLAQSVIPTSAPSIRGTLDPRRPRALRDNTTSRTQPAGSSSAQVKPPSTPLRAYNSGNTVYGRSTPTTSTTTNTTAYNVRPSGPGPSNLRQSYAPNGFRPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPI5</accession>
    <name>A0A1Y1UPI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873287.1">
        <property type="nucleotide sequence ID" value="XM_022018001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPI5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPI5"/>
    <dbReference type="GeneID" id="33559810"/>
    <dbReference type="InParanoid" id="A0A1Y1UPI5"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55266" checksum="2282688CAE81A8DE" modified="2017-08-30" version="1">MSDSTDAGPVPLHIPAILLNPTNRAAKQLEAHNAQQRERVHAKRDKQSTRGDVVSGSKQGKRVIRRKDNAAFISNPHISLPTRSDYYPSVPLQARRGPLFPPETVPRSSHIPSVERPPRDPFSSDSKNGTFGTSLKGVRALLRNKGRRAEKLILVVEKEIRDWLDGREWINAEGMKEKDTVESSEDETDEPQSYASGSTWRLIDPTLVEITGSKSNGAGPSRRLPEQHQVRDVLPRLPSEGSHVAAVLELSRSPAHLTWTIADGFERLVVHLLARYYDLVSWSEDHQDDQNLPIRLTHIIIPQLVRPAALPPSHLLPTPETSDVSSHSEASTDRETESEASDTETELGGYSLDPDISQSTIQPGQLPWDQQSDPGVNGIRTPGIEDAMAELDLKGGMIRLNGLERVWSHDSSSAFGSSEGGSSDWDPMTDSLELPPRSRQLQGSLNGVIDDSASEQSFNLNPESHSAAQHHLNGLAQRALRGRGRGWEDRPTFFDYLYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPQ0</accession>
    <name>A0A1Y1UPQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_615596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873727.1">
        <property type="nucleotide sequence ID" value="XM_022014741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPQ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPQ0"/>
    <dbReference type="GeneID" id="33556549"/>
    <dbReference type="InParanoid" id="A0A1Y1UPQ0"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440528" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="18994" checksum="2085A6188BA30B2B" modified="2017-08-30" version="1">MLFRLSWVAVLATAVMAQLQVDTPPSLIQCQPVQLSWSGGTGPYFLAILPGGQSEAAALENLPNADNSPATWLVNIASGTNVTIRVTDSTGQQQYSFPRTILAGTSSECLGSDASVSVGGTTSASATGGGSDGSSSPTASATSGSGSPTSSSGSGASAASSAAAQTSGAALPGTQVTGIMFTVVGLLTAAFGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ51</accession>
    <name>A0A1Y1UQ51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2 17">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_614253</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="2 17"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873371.1">
        <property type="nucleotide sequence ID" value="XM_022014577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ51"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ51">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ51"/>
    <dbReference type="GeneID" id="33556385"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ51"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 17" id="KW-0288">FMN</keyword>
    <keyword evidence="16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="16 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX39586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="719" mass="80269" checksum="6753BEEB2B70A0BB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ69</accession>
    <name>A0A1Y1UQ69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_679226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873966.1">
        <property type="nucleotide sequence ID" value="XM_022019032.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ69"/>
    <dbReference type="GeneID" id="33560841"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ69"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="898"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1626" mass="176357" checksum="7C9835D30155802F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQB6</accession>
    <name>A0A1Y1UQB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874043.1">
        <property type="nucleotide sequence ID" value="XM_022014879.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="A0A1Y1UQB6">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQB6"/>
    <dbReference type="GeneID" id="33556687"/>
    <dbReference type="InParanoid" id="A0A1Y1UQB6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="62926" checksum="493A7A5786B7C312" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQD1</accession>
    <name>A0A1Y1UQD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_575889</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874055.1">
        <property type="nucleotide sequence ID" value="XM_022013152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQD1"/>
    <dbReference type="FunCoup" id="A0A1Y1UQD1">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQD1"/>
    <dbReference type="GeneID" id="33554960"/>
    <dbReference type="InParanoid" id="A0A1Y1UQD1"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="420"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="845"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="937" mass="102703" checksum="DE4CD1E5B826AFA0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQF4</accession>
    <name>A0A1Y1UQF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874014.1">
        <property type="nucleotide sequence ID" value="XM_022017894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQF4"/>
    <dbReference type="GeneID" id="33559703"/>
    <dbReference type="InParanoid" id="A0A1Y1UQF4"/>
    <dbReference type="OrthoDB" id="2566935at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012824431" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15223" checksum="FA5354C9F257CE8B" modified="2017-08-30" version="1">MLTLFYLPLLLLAPLFTLADSQDPGQGHGKQYYPWNSVKWTMPLSSVKADTTVDLTWTGGSANGYEVYYVPQWEGQDVFESIDIATTSHKSVRWHTPHADQFPDGTTFILGVRDVIAGPKSTWYDLTGLVKFDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQH2</accession>
    <name>A0A1Y1UQH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_655201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874103.1">
        <property type="nucleotide sequence ID" value="XM_022018808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQH2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQH2"/>
    <dbReference type="GeneID" id="33560617"/>
    <dbReference type="InParanoid" id="A0A1Y1UQH2"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="547"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111735" checksum="E993CEE27EE5928C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQN3</accession>
    <name>A0A1Y1UQN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874084.1">
        <property type="nucleotide sequence ID" value="XM_022017901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQN3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQN3"/>
    <dbReference type="GeneID" id="33559710"/>
    <dbReference type="InParanoid" id="A0A1Y1UQN3"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062064">
        <property type="term" value="F:box C/D methylation guide snoRNP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674:SF1">
        <property type="entry name" value="NOP PROTEIN CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674">
        <property type="entry name" value="SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="292" mass="30937" checksum="72639EA27AF924DD" modified="2017-08-30" version="1">MGGAKGLIEVVDGSEMTGDDVGAHGIPNEFHPSSERDTTGDESPSSRQRLDVEDDAARQARLGKIFSELSASPRAGQAAFTAVIDQDRRTFAVPPSDALARVKAFLPMLQSSNADLLARARSDPQAVNMEDTDGDDKVVAMDLGLGVFDVNDHQGGDFGPEVERDDWQADEESDEDDEASDAGRHPPVQTMGEITADAASRDARSYANEEAPQHSIGFGRVGEAQGTAAPNASHANRLMTAENGVPPYLDSHGETVDGAVTSDDTFSESHSSTEDDSSDSEDDGESTDTPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR07</accession>
    <name>A0A1Y1UR07_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein Avl9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_610951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874162.1">
        <property type="nucleotide sequence ID" value="XM_022014228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR07"/>
    <dbReference type="FunCoup" id="A0A1Y1UR07">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="GeneID" id="33556036"/>
    <dbReference type="InParanoid" id="A0A1Y1UR07"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="168"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="779" mass="84962" checksum="C98A4DF54AD7A618" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URI9</accession>
    <name>A0A1Y1URI9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_574678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874231.1">
        <property type="nucleotide sequence ID" value="XM_022013078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URI9"/>
    <dbReference type="FunCoup" id="A0A1Y1URI9">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URI9"/>
    <dbReference type="GeneID" id="33554886"/>
    <dbReference type="InParanoid" id="A0A1Y1URI9"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="30204" checksum="A1425A835AF52FFF" modified="2017-08-30" version="1">MWESRTLNDGSSIPGIAFGTAYTCKEELGPRIENALKAGFRHFDTAQGKAYDNERELGEILSQSGIPRSELFISTKWSNPTSSTPLQACRASLKLLGVDYVDLFLIHQPRNCAGDIPGTWKLMEEIKQMGLARSIGVSNFKVDDLETLLESCTVPPAVNQIYFSPNNYASSKPLLDLAQQHDVQIEGYWTLRPLADDNPQPVVRVAHDIAQKLKCQSEQVLLAWAGAKNVLAVTRTARAERMQSYLGASEVKLDPDDITDLDAAGAKASPDSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URL6</accession>
    <name>A0A1Y1URL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874377.1">
        <property type="nucleotide sequence ID" value="XM_022018794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URL6"/>
    <dbReference type="STRING" id="4999.A0A1Y1URL6"/>
    <dbReference type="GeneID" id="33560603"/>
    <dbReference type="InParanoid" id="A0A1Y1URL6"/>
    <dbReference type="OrthoDB" id="2563749at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="506" mass="55523" checksum="31287CFAB346D18A" modified="2017-08-30" version="1">MAATADEQTLASLSAVDSSTFDLDPSLNSTDTDLFLSQLKNDGDETNDHGIDDATVTAIKQSLSEAQAHADRQAQEIDGKSGSSQSGQLGSEGNPIINPTVHLAPFSKPERAEGALCPEHYKFPSKAEFDIWLAGESSWCHYVQRRTTTPQQRADERMRARVKAHERALQALTPEEAANAPPLKTRKRTNNTSVYMKITYTCHHAGNYNARHSDVLPEKRLRLKTKQSVKCKCRSRIIFTELHSGECQAVYHWKHDGHELFSDAEHQSGRLPSVIDDWLVKQIEAGKEIDEIRRVLSIPETEKQAYVQKVTEDPTLVDPDMPPPLAFQTKVKYPDIYNRFRKLRGPVRAARSPNSKRSSKRRILSPAAEQTPGYGAGPGSAADLDDSVHQTFNIDGVPAGFDLSGLAGTHHADLAEALLRIPAVSGDVNGVIGGPNGSGDAGNDDDHQQLDEQVLKIARMAAEQGERGGEAVSDEEEEEVEEVEDDHGDAEARDEIASVDWNAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USD4</accession>
    <name>A0A1Y1USD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_647813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874588.1">
        <property type="nucleotide sequence ID" value="XM_022017722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USD4"/>
    <dbReference type="STRING" id="4999.A0A1Y1USD4"/>
    <dbReference type="GeneID" id="33559531"/>
    <dbReference type="InParanoid" id="A0A1Y1USD4"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="310" mass="34184" checksum="23A4C67256BA6844" modified="2017-08-30" version="1">MSSKQTKLRIALAQNSPINGPEGTYNPETSKDHPFASVQKNLDKATEFVASAAKQGADVVVFPEYFLQGIVNEGRQYLCLSSDHLTAHLQDLAKKHNISIVGTIVHGKLPSSHSAALPSVSPFTSSDAARKEWVEYLKANPPSDEQVAEPTLHNTAFFIDENGRVLGEYIKKNLWHPERDYLTAGEESHEVFDTKWGKAGFLICWDISHPAAAQSLTDKSVDIVFCPIYWLGTDSEPAINDHEHDEDYERQLTSALCFARAFETETVWIMCNAGGNNEKDLIGGSGVWAPLRGRLGGFDGSDEAVKPLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI4</accession>
    <name>A0A1Y1USI4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_611007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874173.1">
        <property type="nucleotide sequence ID" value="XM_022014233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI4"/>
    <dbReference type="FunCoup" id="A0A1Y1USI4">
        <property type="interactions" value="849"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USI4"/>
    <dbReference type="GeneID" id="33556041"/>
    <dbReference type="InParanoid" id="A0A1Y1USI4"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="430"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="661"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="842"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="984" mass="108581" checksum="FEC852CF47F7CCC7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTJ4</accession>
    <name>A0A1Y1UTJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_612273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874523.1">
        <property type="nucleotide sequence ID" value="XM_022014376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTJ4"/>
    <dbReference type="FunCoup" id="A0A1Y1UTJ4">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTJ4"/>
    <dbReference type="GeneID" id="33556184"/>
    <dbReference type="InParanoid" id="A0A1Y1UTJ4"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="40"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="369" mass="40248" checksum="48BAE2A580372B30" modified="2017-08-30" version="1">MNEVHLGLLSTSDIRITMISNNTSKNNRLILAKRPEKGPVTPETFKLETVDLELVQDGQVRVKVEYSAIEATMRNWLNEARSYIEPVKLGAVMRAIGVGRVVESKSDELKAGDLVYGLLGWQEYWQGSAKEVKKRDTPPGGRDFDHIGLLGSSGMTAYVGMFDIGQLKDGDVVVVSAAAGSVGLIAVQIALAHPKCKVIAIAGSDDKCQMLKDMGCHVALNYKSEDFKQKFKDIGLIDVYFDNVGGEILDMVLGRLNPHARIIACGAVSAYSAKTPYGLVNYTSLISMKAKIQGFIVMEHAHRFAEAGAYLAKLAKEGKMKYDYTILEPKDGEQNGLSRCVEGMELVSSGNNVGKTVIHMSRSDRKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTK5</accession>
    <name>A0A1Y1UTK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_24321</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874533.1">
        <property type="nucleotide sequence ID" value="XM_022012259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTK5"/>
    <dbReference type="FunCoup" id="A0A1Y1UTK5">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTK5"/>
    <dbReference type="GeneID" id="33554067"/>
    <dbReference type="InParanoid" id="A0A1Y1UTK5"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="350"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX40854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="548" mass="61465" checksum="68A1977C412F6A44" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU03</accession>
    <name>A0A1Y1UU03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP proline-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_574606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874344.1">
        <property type="nucleotide sequence ID" value="XM_022013071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU03"/>
    <dbReference type="FunCoup" id="A0A1Y1UU03">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UU03"/>
    <dbReference type="GeneID" id="33554879"/>
    <dbReference type="InParanoid" id="A0A1Y1UU03"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="597" mass="65421" checksum="CF1F5CFC7236AC8E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU04</accession>
    <name>A0A1Y1UU04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_613217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874786.1">
        <property type="nucleotide sequence ID" value="XM_022014477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU04"/>
    <dbReference type="FunCoup" id="A0A1Y1UU04">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UU04"/>
    <dbReference type="GeneID" id="33556285"/>
    <dbReference type="InParanoid" id="A0A1Y1UU04"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="14695" checksum="E0AF70EBE5FC400A" modified="2017-08-30" version="1">MSSSSSKIRASELQSKSKQDLLTQLNDLKTELAGLRVQKIAGGSASKLTKINTVRKSIARVLTVINQKQRQNLREFYKKKKYMPLDLRHKKTRALRRKLTHKESHAITEKQHKRDVHFSARKYALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUE5</accession>
    <name>A0A1Y1UUE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAG domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874873.1">
        <property type="nucleotide sequence ID" value="XM_022014513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUE5"/>
    <dbReference type="FunCoup" id="A0A1Y1UUE5">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUE5"/>
    <dbReference type="GeneID" id="33556321"/>
    <dbReference type="InParanoid" id="A0A1Y1UUE5"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="323"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1237" mass="138481" checksum="987DFFB63B797DF9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUE9</accession>
    <name>A0A1Y1UUE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_613126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022014472.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2575478at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="565" mass="61230" checksum="4A17876170C71776" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5E8</accession>
    <name>A0A1Y1U5E8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_640377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000030">
        <property type="protein sequence ID" value="ORX33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867618.1">
        <property type="nucleotide sequence ID" value="XM_022017343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5E8"/>
    <dbReference type="GeneID" id="33559152"/>
    <dbReference type="InParanoid" id="A0A1Y1U5E8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="85" mass="9868" checksum="C8B118C7B85A1502" modified="2017-08-30" version="1">MLCLQDPTIRRNIIMQSEEVLQPNHFPSDLVLSIPGFEIWDNIWFRDDTFCEASSRRLGILADFHSSDAFTVREKCMERCFGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5E9</accession>
    <name>A0A1Y1U5E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_640419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000031">
        <property type="protein sequence ID" value="ORX33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867613.1">
        <property type="nucleotide sequence ID" value="XM_022017348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5E9"/>
    <dbReference type="FunCoup" id="A0A1Y1U5E9">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5E9"/>
    <dbReference type="GeneID" id="33559157"/>
    <dbReference type="InParanoid" id="A0A1Y1U5E9"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="8">
        <location>
            <begin position="12"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="7">
        <location>
            <begin position="404"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="508" mass="55688" checksum="C8C5047A73727B96" modified="2017-08-30" version="1" fragment="single">QGFVLKTPKGTIDHKPEAALLRKKIFNTLEGIFVKYGGSTIDTPVFELREILAGKYGEDSKLIYDLQDQGGELCSLRYDLTVPFARYLAMNGIQSMKRYHIAKVYRRDQPVMSKGRMREFYQCDFDIAGPSDPMVPDAEILAIVCECLTALEIGEYTVKINHRKILDGIFELAGVPADKTRSISSAVDKLDKAPWSEVRKEMTEEKGLDGKVADKIGEYVGLKGPGYDLLEKLEKDEGLTGVKSAKEGLQDMRILFEYLEILGVYNKMSFDMSLARGLDYYTGIIYEAITEGSAPPSVSPIPSVPPTDSITSSTSKTPAKKPKSTKAQGAEEDAVDETAVGVGSIAGGGRYDNLVGMFAQSAGSGKTDPVPCVGVSIGVERVYSILESKRRGKEEKLRGKETEVFVMNFGKEGLLKERMALAKTLRDNGIKAEYMFKVNAKDRAQLSLVDSEQIPFVAILAPKELAAGTVRIKAQLGKEANKSGDGDVKGEEVKMTDVVQYLKEKLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5Y0</accession>
    <name>A0A1Y1U5Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_280448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867773.1">
        <property type="nucleotide sequence ID" value="XM_022012367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5Y0"/>
    <dbReference type="FunCoup" id="A0A1Y1U5Y0">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5Y0"/>
    <dbReference type="GeneID" id="33554175"/>
    <dbReference type="InParanoid" id="A0A1Y1U5Y0"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="143" mass="15818" checksum="FDBAE7FB7B622FDA" modified="2017-08-30" version="1">MAEAILIDRLSKRGSASKILDITVDSAGTGAYHAGEPADERTITTCQKHGVPVTSIARRLTPEDYAKFDYILAMDESNLDTIRQRKPPSSKCSISLFGSYDSSAGRSRTIDDPYYGGRRGFEEAYEQCVRFADGFLDHLEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6N5</accession>
    <name>A0A1Y1U6N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_213107</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868010.1">
        <property type="nucleotide sequence ID" value="XM_022012190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6N5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6N5"/>
    <dbReference type="GeneID" id="33553998"/>
    <dbReference type="InParanoid" id="A0A1Y1U6N5"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="305"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1008"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1210"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1225"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1235" mass="134480" checksum="9DCB13B8A95E5FD2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6X9</accession>
    <name>A0A1Y1U6X9_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BD324DRAFT_640340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="586"/>
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            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="663" mass="74942" checksum="DE8F8C4CF4A80FA2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U746</accession>
    <name>A0A1Y1U746_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">NRRL Y-17943</strain>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="33559133"/>
    <dbReference type="InParanoid" id="A0A1Y1U746"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="61" mass="6846" checksum="50C8814F12E86DD4" modified="2017-08-30" version="1">MTRCRKCLSSTIDQFLHPSTVAGRPMNFRAQNTSHVLRQSSFLHDVDQSHHKPMAGHGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7L3</accession>
    <name>A0A1Y1U7L3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_584133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868286.1">
        <property type="nucleotide sequence ID" value="XM_022013659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7L3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7L3"/>
    <dbReference type="GeneID" id="33555467"/>
    <dbReference type="InParanoid" id="A0A1Y1U7L3"/>
    <dbReference type="OrthoDB" id="2552042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="47662" checksum="7B63944F5B345DC5" modified="2017-08-30" version="1">MPTGLIDPKFCCCAVPLVNAGIHAIIMEQAVLGVAIGVTALTSPNAVGVVVPNFAKVIFAILCLVVTLIQPVGFIGVLREKTTTFKVYAWTNFVAVLSAFICAAALIAVSAVRHEEAIVTCQVGSDWHAINSAQNSTLAEQGEILCSPFAWADIGIMGGLWVLLLLTQLYFIFYTYSYSKSQVKDHKLYHSVYSENPEAFTMSILRSSRYNLGSVYSTTTRAVQDDAWDARPSMDSPGMAGVQPGSYHDRSQSGGYYDPAEEELANYHGHPDQGQYYDQGSYGNGYPPHQQMPQAGPSASAGYGGGYPPQNGTMAFPDPHHNEDPHQQAAPAYGGGGGGAGQAYHESSHDGYDFSRTPPRGGEGDYYPHEPEEARSRDPSATPTMTGYTHGQTPGVYGGDGGLQRPLGVQNHPGKWLCRARESRAEFSFTAEGMFGRKSPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U824</accession>
    <name>A0A1Y1U824_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_643551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868469.1">
        <property type="nucleotide sequence ID" value="XM_022017556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U824"/>
    <dbReference type="STRING" id="4999.A0A1Y1U824"/>
    <dbReference type="GeneID" id="33559365"/>
    <dbReference type="InParanoid" id="A0A1Y1U824"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="578" mass="62267" checksum="2AA6FADAC1F478EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8I2</accession>
    <name>A0A1Y1U8I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_583444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868614.1">
        <property type="nucleotide sequence ID" value="XM_022013625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8I2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8I2"/>
    <dbReference type="GeneID" id="33555433"/>
    <dbReference type="InParanoid" id="A0A1Y1U8I2"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="286"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="922" mass="101496" checksum="1004E68298D4CA27" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U924</accession>
    <name>A0A1Y1U924_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase substrate phospho protein PP28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_636312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868802.1">
        <property type="nucleotide sequence ID" value="XM_022016884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U924"/>
    <dbReference type="GeneID" id="33558693"/>
    <dbReference type="InParanoid" id="A0A1Y1U924"/>
    <dbReference type="OrthoDB" id="2565360at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="24406" checksum="0B23327586FA73EC" modified="2017-08-30" version="1">MSRKWKVTRGGGRHFSRDLDPRDILRGNRPAGSDDEENPEEEDSDEDDEEDGEEDQPEMKLSKEMAAMNLKLGNTEEVANPEEDGEPEMSRAERKALKKAQAEAKTKKSVKIKEESDEDEDSDEESAEEEAPKAKGKAKSAAPVEMTRKEREAAEKKAAAERYAKLHAQGKTQEAKTDLARLQEVRRRREAAAAQRQAEADEAAKEAEAKKAKAAGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9S5</accession>
    <name>A0A1Y1U9S5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_653041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869025.1">
        <property type="nucleotide sequence ID" value="XM_022018595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9S5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9S5"/>
    <dbReference type="GeneID" id="33560404"/>
    <dbReference type="InParanoid" id="A0A1Y1U9S5"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="111"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="405"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="770" mass="84747" checksum="37F2FCD01FC78EC0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Z2</accession>
    <name>A0A1Y1U9Z2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_635336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869085.1">
        <property type="nucleotide sequence ID" value="XM_022016801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Z2"/>
    <dbReference type="FunCoup" id="A0A1Y1U9Z2">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9Z2"/>
    <dbReference type="GeneID" id="33558610"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Z2"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="364"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="509" mass="56530" checksum="C5FF290D96EAFA52" modified="2017-08-30" version="1">MMRSTHLLEQSIHGDYTGRYRPQVHFSPPKGFMNDPNGLFVDKHGIWHLYYQYNPTELVAGNQHWGHATSRDLYHWANQPIALFPPDERTGVFSGSAVIDAKNTSGFFPDQDDGVVAIYTLNTPENQVQAIAYSRDGGYTFTPYEGNPVIDIQSNQFRDPKVVWYEDHWVMVIAHSTEFKIGIYTSRDLKTWSPSSSVSYLGILGLQYECPNLVPIPVKANGSSTGEQVWTLFISINPGAPLGGATMLYFPGDFDGYSFVPHDSAARLADFAKDNYAAQFFDGTAPGEAVSIAWANNWQYTNVLPTANEGWRSIMSLPRKNFLTRLERTGWALVSEPYDLSPILNSRLSHDTDFVNKTTDVDFSSAGSGAIYFSIKLPDSQARYGDEAAFSFAVSAPSSKESVKGGYMFGGPNAGHAWLDRGNTKGFGSDNPFWNDRFSVAQVSAARSIWGVIDRSVLELFIDDGAYSATMLFFSEEPLTLLRIGTEGMPEGTSIELEVHDLHSVWRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA49</accession>
    <name>A0A1Y1UA49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_633114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869115.1">
        <property type="nucleotide sequence ID" value="XM_022016593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA49"/>
    <dbReference type="FunCoup" id="A0A1Y1UA49">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA49"/>
    <dbReference type="GeneID" id="33558402"/>
    <dbReference type="InParanoid" id="A0A1Y1UA49"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="299" mass="33298" checksum="FAABF17B64ECF9B7" modified="2017-08-30" version="1">MMSSTGPSKIHSVAASGFSSGTNELYDRARPSYPPEAMHTIARALPSREGQGGLKLLEVGSGTGIFTRLLLHPPSDDYPKIPVDTLIAIEPSDGMRETWKVALNQIPSSATSSRTVANVAGSFEDYSEVDKLGVGKGTVDGVLIAQAFHWCQNLDAAVREAASYLSSGSPLVFVWNIESNDAGWCAEVRNLYEPFGRISPQYYLGKWRAVFDTPAYKALFEPQEESSSCWTLPMTEDQLVERLFSKSYLTEHHLNGSARVDFEKQLRKIIREGEKEWVNKETGTFLYKYNTDVVIMRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA65</accession>
    <name>A0A1Y1UA65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Synaptobrevin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_104894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869139.1">
        <property type="nucleotide sequence ID" value="XM_022011918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA65"/>
    <dbReference type="FunCoup" id="A0A1Y1UA65">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA65"/>
    <dbReference type="GeneID" id="33553726"/>
    <dbReference type="InParanoid" id="A0A1Y1UA65"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090161">
        <property type="term" value="P:Golgi ribbon formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042887">
        <property type="entry name" value="VAMP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46897:SF1">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="132" mass="14154" checksum="78205B896D0BEA9F" modified="2017-08-30" version="1">MSEQPYDPYIPSGSRGPAENGSGGSNGAGGGGAQKQKIRAIQDQIDQSVSIMHDNITKVAERGERLDALQDKTDTLAVSAQGFRRGASRVRKQMWWKDTKMKILSPVGIGICVLVVIIVVPIVKAVTGNHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA77</accession>
    <name>A0A1Y1UA77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_633257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869144.1">
        <property type="nucleotide sequence ID" value="XM_022016607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA77"/>
    <dbReference type="FunCoup" id="A0A1Y1UA77">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA77"/>
    <dbReference type="GeneID" id="33558416"/>
    <dbReference type="InParanoid" id="A0A1Y1UA77"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666026" evidence="5">
        <location>
            <begin position="18"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="75"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="482" mass="52322" checksum="2FDA8BEB8964C015" modified="2017-08-30" version="1">MLSNLALLLASGTLAIACDELPIASWSYDGPPPFQYQTASWDPKVFHKLGGFSPWFPSTGVYGVPGYPGQVPDGCSVDQVQVYMRHAEREASGGTARGIAALVKKLANSTFQSSDPNIQYLQTWNYSYPAEYLSPLGYSDATAAGVAFQHAYSPLLGASFYFNNTGPKIPIRSTDQERVNATANAFAAGMMGFNYSAFSNWLVTPDSSTTFNSTLASNNCPAVNTIDSTANGIFNSYFQPLVRDRLAPLMPGFNLTTNDVGSLMNACPFDSFNRLSPSPICSIFTPEEWLGYNYAYDLNQFDNAGYGGPIGTAWGVGWVAEMIARLNDSAVIPVGSVNTTLDSNPATFPLNSSVYLDFTHDTSLESSLTAMGLFKADYNGNVTLDQIDPNRAWQSALISPMGGRLFVERLQCQSTGNQSTYPFVRMLLNSAVVPLYTLTECNHSWGANQGLCELPLFLESQTFALNGANFSNCYNNYTNVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAA0</accession>
    <name>A0A1Y1UAA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_636069</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868737.1">
        <property type="nucleotide sequence ID" value="XM_022016862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAA0"/>
    <dbReference type="FunCoup" id="A0A1Y1UAA0">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAA0"/>
    <dbReference type="GeneID" id="33558671"/>
    <dbReference type="InParanoid" id="A0A1Y1UAA0"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="224"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="656" mass="71398" checksum="5328DEE95B6271A6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAK2</accession>
    <name>A0A1Y1UAK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_636485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868837.1">
        <property type="nucleotide sequence ID" value="XM_022016899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAK2"/>
    <dbReference type="GeneID" id="33558708"/>
    <dbReference type="InParanoid" id="A0A1Y1UAK2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="168" mass="18697" checksum="E3B2A466D7487C41" modified="2017-08-30" version="1">MNQAPAATQITKTTLTPQHALTPTRIRIIPSPDLLRLEPVKDGDIEARIVLRAAKREPRKDIPEVGVAMTLTVPTKWSPPLYDEDAEPGPEINPYDRELVLPVIPGRPTPKVNLLNTFVPPEDTDTSKIIMERREGNAGNFQFWSGGKITMFMRQASSWRLSMGTGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAS8</accession>
    <name>A0A1Y1UAS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_634049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869364.1">
        <property type="nucleotide sequence ID" value="XM_022016697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAS8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAS8"/>
    <dbReference type="GeneID" id="33558506"/>
    <dbReference type="InParanoid" id="A0A1Y1UAS8"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027135675" description="Alpha-L-arabinofuranosidase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="4">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="346" mass="35965" checksum="ACFF25704CBE30C5" modified="2017-08-30" version="1">MFTLALTTAFALLSSLVASQPCDIYAIGNTPCVAAHSTTRALYSKYNGPLYEVVRASDGQYQVISTVSAGGIANSGVQDSFCAGTTCSIYAIYDQSGNGNDLLPAPPGGAMSGPGPNGYDLMANATMAPVLLNGQKVYGVYSPTKTGYRNDNTKNVPTGNNPEGMYWVVDAQHYNGICCFDYGNAETDNTDDGAGTMEALNFGLMIGTTHGAGSGPWIQADLENGIFAGNTPGAFNTPASENPNNPTITSEFATGIVKGDSSNLWAIRGGDAQSGGLTTFYSGSRPSGYYPMNKKGAIILGIGGDNSNNAVGTFYEGAMVSGYPNDNIEAYVQADIVQNAKYSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB01</accession>
    <name>A0A1Y1UB01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_604078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869398.1">
        <property type="nucleotide sequence ID" value="XM_022013972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB01"/>
    <dbReference type="FunCoup" id="A0A1Y1UB01">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB01"/>
    <dbReference type="GeneID" id="33555780"/>
    <dbReference type="InParanoid" id="A0A1Y1UB01"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="8">
        <location>
            <begin position="497"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115713" checksum="2AE54F19B43F89FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB50</accession>
    <name>A0A1Y1UB50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 76-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869458.1">
        <property type="nucleotide sequence ID" value="XM_022016489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB50"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB50"/>
    <dbReference type="GeneID" id="33558298"/>
    <dbReference type="InParanoid" id="A0A1Y1UB50"/>
    <dbReference type="OrthoDB" id="3223195at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013254280" evidence="1">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="436" mass="48512" checksum="B8F0EEF6A975B8A8" modified="2017-08-30" version="1">MVVFSRKSLMTLIPLVAALPSKRDSSPAILNSSYVNPHFQQSCDNVWSYSTDSFQYLLSLLNGTDSDFPTGWVGQNGWTNIAQWDYQQHSKLFYDQYKINETYYAYNPTGCYAYWHNPLADCYNDDAGWAALSSLEGYEAYGDPVFLAWAESVFEFVDGHGFIHQSDLDAGYLVDTKWPNTTLQATCNGQSMYGGVYWMNGAPMDPNQGGAGDPDVNAVSSGLFALLGAELCRITGDQVYCDRAYEAIQWIDRFLVRPDGLIYDHINGTSCEVKDWTFTYNAALYLGAYGVLGHITSNQTALDIAKQVAITSMNTPVWNTDQGVIFEGAGNVTQGNDAIGFKSVLIRNLHRISQWMDSDVQEAIRQYVNIQYWSLVNNDSNNPNMPIQYGRNWTGTYEVSTGQTMVAALDVLNALILNPQSAFPDTNVTNMPVIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBN5</accession>
    <name>A0A1Y1UBN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small ubiquitin-related modifier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869641.1">
        <property type="nucleotide sequence ID" value="XM_022018519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBN5"/>
    <dbReference type="FunCoup" id="A0A1Y1UBN5">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBN5"/>
    <dbReference type="GeneID" id="33560328"/>
    <dbReference type="InParanoid" id="A0A1Y1UBN5"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000202">
        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="99" mass="10572" checksum="84B542C73F5342BC" modified="2017-08-30" version="1">MSDNGSAPPADTKPKAEGGDNTLNIKITSSNHDEVFFKIKKTTKLTKLKSAYADRVGSDINAIRLMFDGERIQDGDTAESLGLEEGDAIDVVLEQVGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBX8</accession>
    <name>A0A1Y1UBX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869707.1">
        <property type="nucleotide sequence ID" value="XM_022018439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBX8"/>
    <dbReference type="GeneID" id="33560248"/>
    <dbReference type="InParanoid" id="A0A1Y1UBX8"/>
    <dbReference type="OrthoDB" id="2559882at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="93" mass="9763" checksum="1FD53DAC8DE95338" modified="2017-08-30" version="1">MATNPSHSANASHAVDPQHESKVPYGVQNAAPKGLEEALPDSVHNTDPTKDNKNISHATGPSKVPGAIQKAAPEGLERALPESIHPTNKFKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC56</accession>
    <name>A0A1Y1UC56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FeS cluster biogenesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_603993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869330.1">
        <property type="nucleotide sequence ID" value="XM_022013969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC56"/>
    <dbReference type="FunCoup" id="A0A1Y1UC56">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC56"/>
    <dbReference type="GeneID" id="33555777"/>
    <dbReference type="InParanoid" id="A0A1Y1UC56"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000010">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.5, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19279" checksum="9F60BB925BAF39C0" modified="2017-08-30" version="1">MPTFSQSSSSSSSSSSPPPPSSISSGSSSRSRIKVTPPSLEAIKNEGYFDDDIALIPPDQAVLDITPSSIRQLVKITSKESPEVLAKGLALRVGVDNGGCHGYQYTMALTEERNVDDYVMQPQGIDCIPVVVDLISLRLLKGSTLHYGSELIGSSFQLMNNPQAKQGGSCGCGVSWEAKEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCB4</accession>
    <name>A0A1Y1UCB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TFIIH p62 subunit, N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_631124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869847.1">
        <property type="nucleotide sequence ID" value="XM_022016410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCB4"/>
    <dbReference type="FunCoup" id="A0A1Y1UCB4">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCB4"/>
    <dbReference type="GeneID" id="33558219"/>
    <dbReference type="InParanoid" id="A0A1Y1UCB4"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="649" mass="70602" checksum="6F0274804B936EF9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC3</accession>
    <name>A0A1Y1UCC3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_631223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869857.1">
        <property type="nucleotide sequence ID" value="XM_022016415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC3"/>
    <dbReference type="GeneID" id="33558224"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="63" mass="7076" checksum="4CCBF24807D15D89" modified="2017-08-30" version="1">MAYVNTHWLRGRGWRIDAASRGKRERSTRTVPCMSSRHKERAGTVTVCRHSTALNASFGAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCK9</accession>
    <name>A0A1Y1UCK9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_84588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869444.1">
        <property type="nucleotide sequence ID" value="XM_022019265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCK9"/>
    <dbReference type="GeneID" id="33561074"/>
    <dbReference type="InParanoid" id="A0A1Y1UCK9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="195" mass="21605" checksum="9CF856AE7C9A782A" modified="2017-08-30" version="1">MSARTLRGALVQATRHSANTARSVPSAWEVSKRSVELGNGGCWSSSKDSDANLSRLQRTVYAMTKFHHDEDTNSAWRRLSVAPFAVRNGSGQISIKVAAIDDADQCVNALRWMSWEKLVKEIKSESTPDSSDVDEVRFWEPVHGRIVLPEPTSPFHERLCEMTVNCQTVPEDDAQSEGNIGCLGEPRRSTLGSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD32</accession>
    <name>A0A1Y1UD32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_632877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869637.1">
        <property type="nucleotide sequence ID" value="XM_022016570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD32"/>
    <dbReference type="FunCoup" id="A0A1Y1UD32">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UD32"/>
    <dbReference type="GeneID" id="33558379"/>
    <dbReference type="InParanoid" id="A0A1Y1UD32"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="140" mass="15590" checksum="C962330D1ED55F1F" modified="2017-08-30" version="1">MNSLASCIFCKIVKGEIPCMKLLETESVLAFMDIGPIAKGHCLIIPKYHAEKLTDLPEDQMKDILPACKKIATATRADNFNLLQNNGRAAHQVVDHVHFHIIPKPSDAGDKEGLVIGWPTQKDLSKDEISKIFEELKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD55</accession>
    <name>A0A1Y1UD55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_100353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869646.1">
        <property type="nucleotide sequence ID" value="XM_022011906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD55"/>
    <dbReference type="GeneID" id="33553714"/>
    <dbReference type="InParanoid" id="A0A1Y1UD55"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013073197" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="78" mass="8772" checksum="C9B9E77EFA9E42E8" modified="2017-08-30" version="1">MTSPPALMRSCSALDHGILILTVLLLLTFAPLAHGMNPLWTSYYCRQQCQTAFTMCIAMAGECLASLRRNRGWNRRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD66</accession>
    <name>A0A1Y1UD66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase ligase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_101839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869677.1">
        <property type="nucleotide sequence ID" value="XM_022011911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD66"/>
    <dbReference type="GeneID" id="33553719"/>
    <dbReference type="InParanoid" id="A0A1Y1UD66"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="61"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="272" mass="31038" checksum="B9D111A9A0259D9B" modified="2017-08-30" version="1">MWSIHKLNAKGKRTNEGYPDVPSSQDALQNLQTTFDEQWGFTAEDLERFPALRKRNFWCIQRHQARALHYDLRMQLDGATYSWAIPRGLLGMSKDGEVNRLAVETTLHPISYTTHEGADGRLLPSGERGGTLLWDIGTYTISYPWTGEGSDSDNERERRKKKRRSMIGIESAIHESNSDDPNGRHEEDKFRQAMRRKVRMGKSRSIHFTLSGGYKMTNHHYILVLSGGNTWAPTYSDGYPWGPGGEEGEEFGRSVKSLRRAKDGPEDLEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDS5</accession>
    <name>A0A1Y1UDS5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_631102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869838.1">
        <property type="nucleotide sequence ID" value="XM_022016405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDS5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDS5"/>
    <dbReference type="GeneID" id="33558214"/>
    <dbReference type="InParanoid" id="A0A1Y1UDS5"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="113"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="339" mass="37687" checksum="D4A4DDA23CFC80CB" modified="2017-08-30" version="1">MSGTSLSEPMRFPRAEYCNLPNRKPSPVKGTPERAGLDTILAHFKDSELQLPVSEGSTEVRGLDDHEKMFLSEEAMLRYLKATKGKVKDAVTRLEATIVWKRTLGMWDIEAVAEEVAPEFESGKVTFAGYTRLSQPMLYTWTSKNVLAASPRQVKHMMFCMDRLIDLQLAGVPGVMFCADVSGKTQTQSGAMSVARQILKYLQAHYPERLGNAALLKLPWLGSLFVSLMWPFVDSDTSKKIHVNPDLSKDLVPKEILLEEYGGNLKHEFSMPYLDALVKLCLERRAGNLERWKAAGRTVGISEWDIFEPIPGSPSAGDTQEQIGNGHAIQTADEASKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDU5</accession>
    <name>A0A1Y1UDU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_652234</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869850.1">
        <property type="nucleotide sequence ID" value="XM_022018463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDU5"/>
    <dbReference type="FunCoup" id="A0A1Y1UDU5">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDU5"/>
    <dbReference type="GeneID" id="33560272"/>
    <dbReference type="InParanoid" id="A0A1Y1UDU5"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="216" mass="23348" checksum="84C195E59551A2A9" modified="2017-08-30" version="1">MSGSSLSTSYPEVKALLESNQKWAASVEEQEKGFFENSAKAQYPKFLWFGCGDSRVPESTLMAQKPGSVFVHRNIANQFQPNDSSANAILEFAVGTVGVDHILVVGHSECGGCIAAHKMSPPTKDSPAPSSNSPLMSFLGPVIELRHSLKEGSTVDDLIAENVKMSVKNIVASPVIQSSWEKHAKGEMRPVYVHGWTYDLSTGLLKDLEVSQGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDX3</accession>
    <name>A0A1Y1UDX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_580590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870334.1">
        <property type="nucleotide sequence ID" value="XM_022013446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDX3"/>
    <dbReference type="FunCoup" id="A0A1Y1UDX3">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDX3"/>
    <dbReference type="GeneID" id="33555254"/>
    <dbReference type="InParanoid" id="A0A1Y1UDX3"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="194" mass="21218" checksum="03FD6E82D3173C6F" modified="2017-08-30" version="1">MASIAPSRAAPPPPPQDEEGEDSGASARERLLAGAKHDNEELVEEALNELEDINHVDGLGNTALHYAIIHASTSTLEPILCHDSCDVDIRNRQNGDTPLHIAVRQRWEDSEGLRLYLVQSLLEAGADTKIRNRYNEKPVDLLPRPDSSADPNSDDEQVRAALRKAEAEAMVADRGDIVQEDDLIDPNDVASDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE08</accession>
    <name>A0A1Y1UE08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_608960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870353.1">
        <property type="nucleotide sequence ID" value="XM_022014132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE08"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE08"/>
    <dbReference type="GeneID" id="33555940"/>
    <dbReference type="InParanoid" id="A0A1Y1UE08"/>
    <dbReference type="OrthoDB" id="2565100at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011988059" description="CBM1 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43978" checksum="9CB395623780FE94" modified="2017-08-30" version="1">MLAMSPLTLLFLSAFLRPTIAQAVIGLFDASGSPVSMDNLPLPASTALSASRTTSSEQYESNAYRSSTAPSTGYAASATITSVPPFLVPTPVPDGTVYTSTEGDSCGEWGCGKVVSPEVQSTCAPAVMSWAHSSMKCGYGHVRNSAGYCMPASWYSTSLGCYETTIILRRSRCDRGDRVPRNLTLSQKPPISLKAVMQRRTRRLVQNVTITEKIPVTMTESVTLTRTMHETSLVDLTTTEKVTDTVTKTSVYNQTIMETATETKTLSLPTTVISKEMMTVTSVQAIPTTVVSTQVMTEVMTDTVIDTKTLLHTLTDTQIVQHNLTKVQTQTEVKTQTQLDTIVQTDTATLTHTLKEIATETMVDTVLQNISVTQTQLQTLVQTQLATLTEEKLATSTANRYRTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEE6</accession>
    <name>A0A1Y1UEE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870005.1">
        <property type="nucleotide sequence ID" value="XM_022016201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEE6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEE6"/>
    <dbReference type="GeneID" id="33558010"/>
    <dbReference type="InParanoid" id="A0A1Y1UEE6"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="557" mass="62569" checksum="1750E09BD8194620" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEE7</accession>
    <name>A0A1Y1UEE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_629377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870013.1">
        <property type="nucleotide sequence ID" value="XM_022016206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEE7"/>
    <dbReference type="FunCoup" id="A0A1Y1UEE7">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEE7"/>
    <dbReference type="GeneID" id="33558015"/>
    <dbReference type="InParanoid" id="A0A1Y1UEE7"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="705" mass="79697" checksum="78F53236665C65E8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF67</accession>
    <name>A0A1Y1UF67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870727.1">
        <property type="nucleotide sequence ID" value="XM_022018279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF67"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF67"/>
    <dbReference type="GeneID" id="33560088"/>
    <dbReference type="InParanoid" id="A0A1Y1UF67"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="127"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="31389" checksum="8C435BADB354D01C" modified="2017-08-30" version="1">MSQEHRQQSAFRRQIFLPRFQNFERYKSPSSDELRVGPAPSEKAVRGWSGTLASYWFLPRPESTSMPFVKHDAQPPASWPTETSYLVKCRLSPTFPSALHSFLFDKNTVSSPAARYNPRPVIHPSHLSIKVIKDPGHPANGQAGLFTKRKIPPGELVIPYLGVIHHSLVADADSDVATIAVIPDEHEHSDYDLSLVRISAHDPLSPFFGYHVSIGVDAAHAGNAARFVNDYRGISSEPNAEFCLGHGAAGELRMEIWSLKKGIAKGEEVLVSYGKSWWSARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFH0</accession>
    <name>A0A1Y1UFH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_484658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870378.1">
        <property type="nucleotide sequence ID" value="XM_022012913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFH0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFH0"/>
    <dbReference type="GeneID" id="33554721"/>
    <dbReference type="InParanoid" id="A0A1Y1UFH0"/>
    <dbReference type="OrthoDB" id="5593376at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="732" mass="79414" checksum="345CBDCA91F5C36F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFV1</accession>
    <name>A0A1Y1UFV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 26S proteasome regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_627423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870918.1">
        <property type="nucleotide sequence ID" value="XM_022015996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFV1"/>
    <dbReference type="FunCoup" id="A0A1Y1UFV1">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFV1"/>
    <dbReference type="GeneID" id="33557805"/>
    <dbReference type="InParanoid" id="A0A1Y1UFV1"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="284"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="534" mass="60169" checksum="6550213B2E8DDE99" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGM4</accession>
    <name>A0A1Y1UGM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870723.1">
        <property type="nucleotide sequence ID" value="XM_022018277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGM4"/>
    <dbReference type="GeneID" id="33560086"/>
    <dbReference type="InParanoid" id="A0A1Y1UGM4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="173" mass="18504" checksum="C1B0338570F32EBE" modified="2017-08-30" version="1">MALACSSRMCFSPAMQPLVRRSIRRYASSSRSRSSLGSSATGHPRSSAKPPPPPPRRNPNARPSSPPISGRTGRHKASDHNPSATAVPPESAPLSSPAAPRSPEPAKKDDPTSRSLWQSYKGLRPDAKLIFAGTLVVGAGLIYWIDGIYPEDETAELSTILDRPPETSQTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGV0</accession>
    <name>A0A1Y1UGV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_625496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871306.1">
        <property type="nucleotide sequence ID" value="XM_022015805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGV0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGV0"/>
    <dbReference type="GeneID" id="33557614"/>
    <dbReference type="InParanoid" id="A0A1Y1UGV0"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="249"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="46087" checksum="3706CF2C387E5D30" modified="2017-08-30" version="1">MLEPSSEGDDEETVVEADVADLKSEKKKKKTTDEEQKKTKKSKKSSKEESNDILVEEKKEKKEKKEKKEKKEKKEKKEKKEKKEKKEKKKEKEKKDKTVEVEAEAEAEVGSPEQETQGKKDKKRKASEAEGIIYGEGDGEAAQSGKKQKKKKRKSKDADEEADVEQSVEGGSSGSKKRSREPVTESADVTTVSEEPKKAKGKKKQKAVGPSISLGEIESDERMSETAKNAIIYVHQHSSQLVPSEPATQGWKFNKAKQNWLVKHVFDNAQVPDEYVELVLGYLKTIQGMGRAHLIEVAKGHSKPKAAAIEQAAVEHEDSKAKPTTTQDNTVNAKDGISGDASRKTDQTTAADANEDDVTAKRVTFDQTVSSGDAQADEQQLMADDEAAEAAAATDEANRIQIRIDRAKKVLKILGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGX3</accession>
    <name>A0A1Y1UGX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_627141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870846.1">
        <property type="nucleotide sequence ID" value="XM_022015968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGX3"/>
    <dbReference type="GeneID" id="33557777"/>
    <dbReference type="InParanoid" id="A0A1Y1UGX3"/>
    <dbReference type="OrthoDB" id="2589846at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="135" mass="14907" checksum="EE0C05D107AB819E" modified="2017-08-30" version="1">MFDNIAAMFGGGLGVGAAGMVSLSVQGELQQLKSAPVLNPHFGMVIKYLDCLNRLMDGLVLTMGPSGVTPWLVEVQTLIRLLQKRVFQRMPLTMPERSALLNFASYWRRMVQPPYAMGRPEAQLVLITLTELASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH22</accession>
    <name>A0A1Y1UH22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871389.1">
        <property type="nucleotide sequence ID" value="XM_022018238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH22"/>
    <dbReference type="GeneID" id="33560047"/>
    <dbReference type="InParanoid" id="A0A1Y1UH22"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="339" mass="36191" checksum="235D606870564B6A" modified="2017-08-30" version="1">MADTSFPTSGDTTRVDPLPQFDMSFSAGAWDDRELVRAYDSALEEFHVHHPGPGSWLDKTTALLAKGHPMYGIQDKEAGWYAASKDKTLDASSTSDPQSSKRRKVSSTPNGKASTTTVVNPSPLTTAINPYDLPVDQTTEAGHVNPYGGAFLPPRRQRGSPVYEPSSPPAVSVPLPNGADPQHSGQALSIPRSDHRAGPSRRTRAARTEQRPETVPAGPSHEHGPILGVQATAGTTHEQALGYAMTAQYWAGYWMGVAQSRSETLYTVAQPVPVELPVNVSGPAGEAASEETTSSSEEESSSEEETEDAAANGQNVSTNNVFVTRKQFTRPAVGQALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH91</accession>
    <name>A0A1Y1UH91_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_448988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871459.1">
        <property type="nucleotide sequence ID" value="XM_022012812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH91"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH91"/>
    <dbReference type="GeneID" id="33554620"/>
    <dbReference type="InParanoid" id="A0A1Y1UH91"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="27781" checksum="5A4A1DFFECFFA0B0" modified="2017-08-30" version="1">MASTKENTFLRMNQLLKSDKPVFATFQTLKGVRTSQIICNAGFDAIVIDCEHGNIGDSDMHDSVAIIAAMGVAPLVRVRGDSPALIKRALDTGAHGIMIPMVSTAEDAKRVVSMSKFPPIGIRGQGSPFAPFAQGFKAPYDYVNQYNANTMIMAQIETALAIQNVEEIAQVEGLDMLFIGPNDLALSMLGYVPSNGTEQNYLDAIDKVVATARKYGKKTGILVNDGATAKKVIGKFDLIVISADAKLFGLALGAQVAAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHJ3</accession>
    <name>A0A1Y1UHJ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871505.1">
        <property type="nucleotide sequence ID" value="XM_022015451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHJ3"/>
    <dbReference type="GeneID" id="33557260"/>
    <dbReference type="InParanoid" id="A0A1Y1UHJ3"/>
    <dbReference type="OrthoDB" id="2560848at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="114" mass="11761" checksum="8ED6033F8BAC3DDF" modified="2017-08-30" version="1">MSTEPGHSNSETHLTQSGEPDKRFKENGGGQHGNQGGRQTGFEEIGDGTSRLVTEGTGEDTGTYKPTEHGGEKKDGGQDKRTTAEHGFGGDHEAAVEAGKKGGSASYENGGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHP7</accession>
    <name>A0A1Y1UHP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_680991</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871095.1">
        <property type="nucleotide sequence ID" value="XM_022019104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHP7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHP7"/>
    <dbReference type="GeneID" id="33560913"/>
    <dbReference type="InParanoid" id="A0A1Y1UHP7"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000156">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="139"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="88"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="168"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="536"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX37057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="612" mass="68066" checksum="12A05282BBC35F1E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI43</accession>
    <name>A0A1Y1UI43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_589506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871679.1">
        <property type="nucleotide sequence ID" value="XM_022013778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI43"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI43"/>
    <dbReference type="GeneID" id="33555586"/>
    <dbReference type="InParanoid" id="A0A1Y1UI43"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="199"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="422" mass="44406" checksum="E81736A60AFAABFE" modified="2017-08-30" version="1" fragment="single">MLNASPSSPAANFFAKVNGLSGSSEATKEDGDAWTGGLGRPSIETGGGTDESGRQPGDVRRAVSLRVQGSLGGFRPLREPIGMSFGAAGSNLSASPLSTTTGSTTLRSSSSSYAPPAASRHPLFSHHASPPIRPFEDQDGMSEATLSGISTPPSPSGSVGSSGFSPASAFLSHFSSSGSLRSNSTETAIDAQGARVLDYTLGKLIGRGGFSAVRKAHHVVTGEVFACKIVKRDDLSDSSGSVEKFEEEIRIWQAFPKHPSILPLLEMHRTPTVTFLIVPFLPGGSLLDVLKRENGSDRTARKFFPGVVTAVSALHEGYPGFEGKLLHGDLKLDNFLVDHVGNVIAGLPKEIDGLPHPVLPSASLPYAPPELLRAPPSPPSLAQDIWAVGIVLHALLTGRLPFFDAYDPRLQMKILKGTYAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI47</accession>
    <name>A0A1Y1UI47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_590365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871192.1">
        <property type="nucleotide sequence ID" value="XM_022013788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI47"/>
    <dbReference type="FunCoup" id="A0A1Y1UI47">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI47"/>
    <dbReference type="GeneID" id="33555596"/>
    <dbReference type="InParanoid" id="A0A1Y1UI47"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="418"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="493" mass="55723" checksum="CB76E4B8A1CF8A9F" modified="2017-08-30" version="1">MVQPSFSHPRKPNAEEVISPTAPLDAFLDNQHQSFFEELYKSEAVCLCILRFLPPICRHVVLHTLWSYNPLRTVDLKALCQIDVSAPLNLAEDIVRSAIDRKIFHPIQHKKGKMEWPMNDTFKKGLRNALTGLGKSNSFGVPYVGEDGIDAPDPEELIQYGEDTWESILKYMVSSGLSSSIATVKPKPQVLRLLHASGLMADNNDMSGRRPNLDRLTITSKGFQFLLEDRQTQLWQILMCYLALKEADSERSAETLSVFFSLGCMQLGDSYSASGSFPLAHSALDDLESYGFIYRRPVVNGVPSDQFFPTHLATSLCSGNTITSASQSADEKRFLVLETNYKIYAYTSNELEIAILNLFVDIRIRYRNLVVGKLDRKNVKSAMEKGISAYQIISYLASHAHPQMYNSPPPLLHPTIVDQLHLWDKERNRLKHEDAVMFEFHSKELFDDTEAEARRYDGVLVSVPNSKLLFIDPSIKDGIRDFVMGQQKQLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIS7</accession>
    <name>A0A1Y1UIS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_608367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871945.1">
        <property type="nucleotide sequence ID" value="XM_022014110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIS7"/>
    <dbReference type="GeneID" id="33555918"/>
    <dbReference type="InParanoid" id="A0A1Y1UIS7"/>
    <dbReference type="OrthoDB" id="2588822at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010984266" evidence="2">
        <location>
            <begin position="21"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="511" mass="55252" checksum="F43DAAA4BFECD05E" modified="2017-08-30" version="1">MQSIRSYTLLSLYFVQCCLPLQHAPIRWSHPSRNTPPSTSLPTSQNHKSSKPINRPPQSPSRTSIRGDIALSPRRSPVSSPVIDMSQSRSPQLDAVQPTTPTPHKGARRRRANGKQSVQRKSQNNFNASGDDVGPDNERSSEDDELLFDLLGVPTPAKANTAVPGLLPITKDQMKSSNTRSTKRQENAHDSGRTPSGRDGEAVPPRGKGRRKPRGSMSDSEAFTRPVSARKGKLFQPDSDIQSEDAFTLPPADTSSSAIIRKGKGRPASQKVDQTAMESSQSFDLHSLSQSLPSVSGLEMPPPTSAKKKKEKKSRKVAASGNDESSVWDMPDMSGPGGAQTLTWQQQLQATELSSTPRRDKSLHTSTKSLNHASDPKPRARPKSSHPANIPNPPISYPLVNKPTQTRRRSLDGSVPLSAFDHTIPYHTGFNVNRAPQTPIRLPTSQSAASDLPILQGDFPRLKHGSKGPLGGLVPKSNPAGGPVQGIKYAGPTFHNSPHAASLPKPDLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIT9</accession>
    <name>A0A1Y1UIT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_578849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871889.1">
        <property type="nucleotide sequence ID" value="XM_022013343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIT9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIT9"/>
    <dbReference type="GeneID" id="33555151"/>
    <dbReference type="InParanoid" id="A0A1Y1UIT9"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="231"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="812" mass="87984" checksum="7FC1C31DBF6C1F7C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIY5</accession>
    <name>A0A1Y1UIY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA ligase OB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_624236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872010.1">
        <property type="nucleotide sequence ID" value="XM_022015673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIY5"/>
    <dbReference type="GeneID" id="33557482"/>
    <dbReference type="InParanoid" id="A0A1Y1UIY5"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029319">
        <property type="entry name" value="DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050326">
        <property type="entry name" value="NAD_dep_DNA_ligaseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47810:SF1">
        <property type="entry name" value="DNA LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14743">
        <property type="entry name" value="DNA_ligase_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase OB-like" evidence="6">
        <location>
            <begin position="881"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="956" mass="107326" checksum="2E678B1BB11AC1E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ33</accession>
    <name>A0A1Y1UJ33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_624033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871966.1">
        <property type="nucleotide sequence ID" value="XM_022015653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ33"/>
    <dbReference type="FunCoup" id="A0A1Y1UJ33">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ33"/>
    <dbReference type="GeneID" id="33557462"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ33"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="539"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116974" checksum="E3F4CB74A0748DDA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJE9</accession>
    <name>A0A1Y1UJE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dimethylaniline monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_619870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872100.1">
        <property type="nucleotide sequence ID" value="XM_022015219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJE9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJE9"/>
    <dbReference type="GeneID" id="33557027"/>
    <dbReference type="InParanoid" id="A0A1Y1UJE9"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="68128" checksum="C452B46FFCA7E543" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJQ0</accession>
    <name>A0A1Y1UJQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872131.1">
        <property type="nucleotide sequence ID" value="XM_022015239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJQ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJQ0"/>
    <dbReference type="GeneID" id="33557047"/>
    <dbReference type="InParanoid" id="A0A1Y1UJQ0"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="95"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="460" mass="49606" checksum="1C6A46EAA8139203" modified="2017-08-30" version="1">MMVSTHKAKDWPFPNDPEPRDAVLPLLRVKPWMPLHAAPRIYLINAQVIDTEEGKLFDGLQTIEIIDGHIASIGLTDSFTYTDTKAPKIDLDSRFVCPGLIDAHVHISAIPGSNTIADMVRTNAQVTTLRSTYVLKSMLSRGFTTIRDTGGATKDTANAIAEGLLEGPRLFQCGFAISQTGGHGDFSPAQSGGDGLGCCSGHSGSLGRTADGVPAVLKATREELKQGADFIKIMVGGGVASETDAIETVQYSAEEIRAITSTAWQMGKKMCTAHAYTPEAIEHAVSNGVRGIEHGNLIEQKTAEMMARKGIYLTPTLSCYGIMVRRPFENFLPPSGQIKNKQVMQQGLEALRMADEAGVTICYGSDLLISMHALQTEEFTVRSRILPAAKILKHATVNPAKMLGQEGKLGVVRQGAFGDLIVLKKNPLEDICVLDRPEENLIAVIKEGRLVSGELVGFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJS9</accession>
    <name>A0A1Y1UJS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_620393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872233.1">
        <property type="nucleotide sequence ID" value="XM_022015278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJS9"/>
    <dbReference type="FunCoup" id="A0A1Y1UJS9">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJS9"/>
    <dbReference type="GeneID" id="33557086"/>
    <dbReference type="InParanoid" id="A0A1Y1UJS9"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="62"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="8">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="217" mass="23854" checksum="CE42853977527A2B" modified="2017-08-30" version="1">MYGDLALQLVTASHRSTLANTAQLPLPKYALSLILSICLETRQLGNSITAAAEQHGQASLSQDRGLLCSLTVQHLAARRNKRCLLAYLQNRVGGIKERWWDAGGGLAYLLSPGTSSGVTSEDAPDLRSALSPQELDFLRGYNSLILDYKSDFLDVLDLTASIDRPPSELMVDVRVVKDAGEVILEGGERIDFRKGERFRLARGQVERLIVQGFLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJX5</accession>
    <name>A0A1Y1UJX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_401941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871814.1">
        <property type="nucleotide sequence ID" value="XM_022012686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJX5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJX5"/>
    <dbReference type="GeneID" id="33554494"/>
    <dbReference type="InParanoid" id="A0A1Y1UJX5"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013344944" evidence="2">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="151"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="300" mass="30739" checksum="DA3A1AA4D45E7C23" modified="2017-08-30" version="1">MSRVTIKAFLTLAVFALPSIAIPVIDAHVEVPAKRVVKRGCGVRPSVSAASPVSSTAAQSSQIGANFVGFSGSVSHHAAASSTSFQVEQTAIEIHHPSSLAPPIPPPSPAPSPPSSSAEPSSTASSLPQPSSPGGGGGGSNGADDGSSGDAQIDQFLNLHNTFRAEYGAGKVTWNTTMAQFAADAANTCNYGHTGGPYGENIAAGVGGGYNITSAFDSWANEASLYNWNSPGYQESTGHFTQIVWKGTTQIGCAMASCADNTIFDNYGQNSLYVVCEYAAAGNIVGNNGEYFKLNVGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK70</accession>
    <name>A0A1Y1UK70_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_409240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871924.1">
        <property type="nucleotide sequence ID" value="XM_022012705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK70"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK70"/>
    <dbReference type="GeneID" id="33554513"/>
    <dbReference type="InParanoid" id="A0A1Y1UK70"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="151" mass="17053" checksum="2A4A61F2B3D81D32" modified="2017-08-30" version="1">MHWESGNTHRRKSSTSHASGSVSKRKSRQMLSIRSLHSLLYIHSERFVLDQSSLKSSYKMRLLGSFLGALCFFLPFVLGDQAAETFKYESDITRLRSLVIHSLYSHKDVFLRELLSNANDALEKLRLTALTDRHVMSGGEANVTIEIPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKC0</accession>
    <name>A0A1Y1UKC0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_641976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871941.1">
        <property type="nucleotide sequence ID" value="XM_022017460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKC0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKC0"/>
    <dbReference type="GeneID" id="33559269"/>
    <dbReference type="InParanoid" id="A0A1Y1UKC0"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="792" mass="88185" checksum="53E477A4C1ABBEEC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKD1</accession>
    <name>A0A1Y1UKD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_621144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872433.1">
        <property type="nucleotide sequence ID" value="XM_022015363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKD1"/>
    <dbReference type="FunCoup" id="A0A1Y1UKD1">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKD1"/>
    <dbReference type="GeneID" id="33557172"/>
    <dbReference type="InParanoid" id="A0A1Y1UKD1"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="173"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="338"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="924" mass="103145" checksum="A01207921F879A5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKF4</accession>
    <name>A0A1Y1UKF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_655808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872450.1">
        <property type="nucleotide sequence ID" value="XM_022018826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKF4"/>
    <dbReference type="GeneID" id="33560635"/>
    <dbReference type="InParanoid" id="A0A1Y1UKF4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="526" mass="58424" checksum="6BCB34932A9DC35D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKS8</accession>
    <name>A0A1Y1UKS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_578520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871722.1">
        <property type="nucleotide sequence ID" value="XM_022013329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKS8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKS8"/>
    <dbReference type="GeneID" id="33555137"/>
    <dbReference type="InParanoid" id="A0A1Y1UKS8"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="148"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="336" mass="34609" checksum="0E837C157D939341" modified="2017-08-30" version="1">MVKACVCGAAGGIGQPLSLLLKLNPLVTELSLYDVVNALGVAADLSHIASPAQVTGYLPPDNGAEKALKDSDIVIIPAGVPRKPGMTRDDLFINAGICATLAQSIAKACPKAFILVISNPVNSTVPIFAEVLKKAGVYDPKRLLGVSHLDIVRASTFVASVVGKPADAAKYVVPVLGGHSGATILPLLSQSQPSIPSEILNDKEKRDALVNRIQFGGDEVVKAKDGAGSATLSMAQAGAEFAEYVLKAAFGGEKVRTVQAYIDLGADAGGAAVQKEIGADLSFFSVNIQLGPGGVEKILPVGDLDDSEKTLLEAAVKELGPSIEKGVSFQPAPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKT9</accession>
    <name>A0A1Y1UKT9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L22/L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_621900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872593.1">
        <property type="nucleotide sequence ID" value="XM_022015418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKT9"/>
    <dbReference type="FunCoup" id="A0A1Y1UKT9">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKT9"/>
    <dbReference type="GeneID" id="33557227"/>
    <dbReference type="InParanoid" id="A0A1Y1UKT9"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="246" mass="28021" checksum="11F677612FE56178" modified="2017-08-30" version="1">MSRTLRGAAIVAQSAVAGPSRLTFRSTPLPNQIQRRHASFGSWFSALVGLKEKPTSSRRDKSGKDPLETNPFDVVVKEQKTVLQTKPTRRLEYRSYTNKDPSIHQISPLKLNNLANQIAGLPVDEAIIQMQHSSKKAARWIKKELEAGKDIAIHERGLKRSLLQVSEAWVQKAKFGPKKIDIKGRGRYGIKIRPFSRLRFTLTEGMTPRQKEEIKFQKDIDRYARGAAIVREDTPLRRKITGNWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL37</accession>
    <name>A0A1Y1UL37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872189.1">
        <property type="nucleotide sequence ID" value="XM_022018029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL37"/>
    <dbReference type="GeneID" id="33559838"/>
    <dbReference type="InParanoid" id="A0A1Y1UL37"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="198" mass="21049" checksum="4A4EED3D6B92CE95" modified="2017-08-30" version="1">MSITSNSSDSSESGHLSPISGSTSWSSHPDLTDIDLIEVPSPTLDPEDGIHTVTGMDPIGRTSFTVWELNYDGTSEVATLSSDGVEARLVKRDRTDTVKVYRDELDTLTFADWGSTAQSPIDPLDAAILRSAVNEVGEWPPGVRFRVLHELSAADVETSQSPGSQTSTHGGSDAELRTDTTNVQDQPNSANGDSVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULI6</accession>
    <name>A0A1Y1ULI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_641551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872268.1">
        <property type="nucleotide sequence ID" value="XM_022017427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULI6"/>
    <dbReference type="FunCoup" id="A0A1Y1ULI6">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULI6"/>
    <dbReference type="GeneID" id="33559236"/>
    <dbReference type="InParanoid" id="A0A1Y1ULI6"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="231"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="428" mass="46921" checksum="D553549822AA6636" modified="2017-08-30" version="1">MGDNLVNFYAGQPPLNRLSFIRPSVDKINALLNAESTRFIAFKDLKPLVQENELGKLVFLDRKAVESRIGDGYMGSGGDSKEAVRTMETYRKPSDNALVFLGIDDRTSARENIETEIQSSEKQVDLANPPGTAFFAVDAGRGAEGEWEISGTQWGDPRSSASSMSGWEAGLFAQARALIDWNTRNRFCPMCGSQTYSLWAGWKRGCITGLEPIPGKEPCPSLEGLHNFAYPRTDPVIIMGILNSAGDKILLGRQAKWPKGMYSCLAGFVEPGESFEDAVRREVMEEAGIEVGPVRYSSSQPWPYPANLMVGCFGRAKDGQRIRFDLDNELEDAQWFDRPTIRSLVSSPTGSKYSEAEIKRLGKLANSGSNHKDDQETANALAPSERKTGEGDAEGDKRGLTRVPPDTAIAGKLIRLWADGGVDLVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULN9</accession>
    <name>A0A1Y1ULN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_617994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872824.1">
        <property type="nucleotide sequence ID" value="XM_022014978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULN9"/>
    <dbReference type="FunCoup" id="A0A1Y1ULN9">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULN9"/>
    <dbReference type="GeneID" id="33556786"/>
    <dbReference type="InParanoid" id="A0A1Y1ULN9"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000107">
        <property type="entry name" value="Chromosome 19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000036">
        <property type="entry name" value="Pre-mRNA-processing factor 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="662" mass="78842" checksum="31809F9BB6A5C584" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULP7</accession>
    <name>A0A1Y1ULP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_617855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872775.1">
        <property type="nucleotide sequence ID" value="XM_022014955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULP7"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULP7"/>
    <dbReference type="GeneID" id="33556763"/>
    <dbReference type="InParanoid" id="A0A1Y1ULP7"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000021">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="541"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="92682" checksum="1B4F3493C9A02BF7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULV6</accession>
    <name>A0A1Y1ULV6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mercuric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_587864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872894.1">
        <property type="nucleotide sequence ID" value="XM_022013758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULV6"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULV6"/>
    <dbReference type="GeneID" id="33555566"/>
    <dbReference type="InParanoid" id="A0A1Y1ULV6"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43014:SF2">
        <property type="entry name" value="MERCURIC REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="7"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="365"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="188"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="479" mass="52272" checksum="B287DBC80A40BB9D" modified="2017-08-30" version="1">MTSLAHYDVVVIGSGQGGTPLCQAFVKSGLKTALIESRHVGGCCVNEGCSPTKTMIASGRVAYLVNRAKEYGVNIKGEITVDQRRVKERKQEIVDSFREGGEKTLKESGVDLLTGVARFLDSKTIAVIDTSGQEIQRLTADKIFVNTGERPVEPPIDGLKGEFAKGVILDSTSIQELDVVPEHLVVVGGGYIGIEFGQLFRRLGSAVSVIQRGRQLFPREDREVAEAVKNILEEDGLAVYLQTAVQSISPGPEGCGATVLYKTESGDVESLNASHVLIATGRRPNTDELNLEAASVKLDSKGYIKVNDLLETSQSHIWALGDVKGPPAFTHVSYDDYRILKANLIDHKGDPSQHRSIKDRDLIAPYVAYMDPQLAHVGLHEHEARERFPDHTIKTATMPMSYVARALETDETRGLMKAVVDMDTDRILGFTCLGLEGGEIMSVVQMAMMGGTKWTVLQDAVWAHPTLAESLNNLWGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM38</accession>
    <name>A0A1Y1UM38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPX domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_649910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872468.1">
        <property type="nucleotide sequence ID" value="XM_022018060.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM38"/>
    <dbReference type="GeneID" id="33559869"/>
    <dbReference type="InParanoid" id="A0A1Y1UM38"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="944"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="971"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1025"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1070"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1198"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1250"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1335"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1382"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="474"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="663"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1405" mass="155159" checksum="F9981F50D35CB6D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM96</accession>
    <name>A0A1Y1UM96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Putative aspartate carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BD324DRAFT_621781</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872569.1">
        <property type="nucleotide sequence ID" value="XM_022015406.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UM96">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM96"/>
    <dbReference type="GeneID" id="33557215"/>
    <dbReference type="InParanoid" id="A0A1Y1UM96"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000011">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000009">
        <property type="entry name" value="Carbamoyl-phosphate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 25" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="23">
        <location>
            <begin position="666"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="23">
        <location>
            <begin position="1201"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="24">
        <location>
            <begin position="1457"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1945"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1945"/>
            <end position="1969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ORX38647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2319" mass="252586" checksum="3F15887A58A4B1F1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMH9</accession>
    <name>A0A1Y1UMH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_598512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873055.1">
        <property type="nucleotide sequence ID" value="XM_022013890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMH9"/>
    <dbReference type="FunCoup" id="A0A1Y1UMH9">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMH9"/>
    <dbReference type="GeneID" id="33555698"/>
    <dbReference type="InParanoid" id="A0A1Y1UMH9"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="658" mass="72259" checksum="DF9AA49621C44E16" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMK5</accession>
    <name>A0A1Y1UMK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873156.1">
        <property type="nucleotide sequence ID" value="XM_022015132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMK5"/>
    <dbReference type="GeneID" id="33556940"/>
    <dbReference type="InParanoid" id="A0A1Y1UMK5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="164" mass="18378" checksum="B8B64EF63BA067EB" modified="2017-08-30" version="1">MIGPKQQSTSHHITDGSPLASSYLPYHDLMNTPSSTRQSGKRPSRASATASTSTHSTDIQSILSKKKKASSNHHPSAPRVPPSDVTIKQILSAHPYRDLRNKKQLKWLMRYECELADGIKRGMVYTSLLVAKDGEKLRDEFWKEMEKEGKVTEAQKAIIDAGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMX0</accession>
    <name>A0A1Y1UMX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_326286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873205.1">
        <property type="nucleotide sequence ID" value="XM_022012491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMX0"/>
    <dbReference type="GeneID" id="33554299"/>
    <dbReference type="InParanoid" id="A0A1Y1UMX0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="90" mass="9329" checksum="C6623CF1AB556275" modified="2017-08-30" version="1">MGSKMSVESAVDAVVRIISILIGILLLLLLPVYLLPTSFSGIPLEQCPRPPSLSVIVATSVLMAHNAGVSLMGSAQFTSGSLFCGIDTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN06</accession>
    <name>A0A1Y1UN06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_619556</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873262.1">
        <property type="nucleotide sequence ID" value="XM_022015181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN06"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN06"/>
    <dbReference type="GeneID" id="33556989"/>
    <dbReference type="InParanoid" id="A0A1Y1UN06"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="504"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="410"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="800"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="896"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX39399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124644" checksum="2B84669BAC7FBAD0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNG4</accession>
    <name>A0A1Y1UNG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GPR1/FUN34/yaaH family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_621874</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872587.1">
        <property type="nucleotide sequence ID" value="XM_022015416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNG4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNG4"/>
    <dbReference type="GeneID" id="33557225"/>
    <dbReference type="InParanoid" id="A0A1Y1UNG4"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="161" mass="17053" checksum="2AD8069644B72D78" modified="2017-08-30" version="1">MVVGMAFAVGGIAQFVAGIFEFVAANTFGMTAFCSYGAFWVSIGLMFWPSSGILSAYEADALPDALGLFMITWCVFTFILFLATFRSSAGLVTLFFLLTMTFLLLAVGYFQDANVAIIKAAGCFGILTALTAYYVGAHGLLTAESAPFSIPNPSLATKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNX6</accession>
    <name>A0A1Y1UNX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_597271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873535.1">
        <property type="nucleotide sequence ID" value="XM_022013877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNX6"/>
    <dbReference type="FunCoup" id="A0A1Y1UNX6">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNX6"/>
    <dbReference type="GeneID" id="33555685"/>
    <dbReference type="InParanoid" id="A0A1Y1UNX6"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="3">
        <location>
            <begin position="117"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="657" mass="71971" checksum="A2A950770C869AA0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP26</accession>
    <name>A0A1Y1UP26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_619187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873160.1">
        <property type="nucleotide sequence ID" value="XM_022015136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP26"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP26"/>
    <dbReference type="GeneID" id="33556944"/>
    <dbReference type="InParanoid" id="A0A1Y1UP26"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="289" mass="30418" checksum="87A7484B2D80A0A7" modified="2017-08-30" version="1">MSIVLKRCEGACHTDSVSVQLNGMASSSFPSSMQAQEYDPAQHSSSADPSGTVSPASLTGLTGIESATGLNTEKLGETSRPQRTTRGQQNMVGADSDQSKKSVSMDDANAVASGSGSRSSHSTSTKRSAKAAARKEAAHLQSQDDLNEFLEEFWTKQITLMEEEDVSAGYALPLARIKKVMKSDEDVKMISAEVPIMFSKACEIFIAELTCRAWLVAESQKRRTLQKSDVAAAIACSDMFDFLIDIVPRDDVEGAGGGTGGAGTTGTANGADEGDDGDDGGGEDEDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPE8</accession>
    <name>A0A1Y1UPE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_607087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873703.1">
        <property type="nucleotide sequence ID" value="XM_022014047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPE8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPE8"/>
    <dbReference type="GeneID" id="33555855"/>
    <dbReference type="InParanoid" id="A0A1Y1UPE8"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51809" checksum="5B381FDB75E26678" modified="2017-08-30" version="1">MTTLEEHHEPGTVENHEQELATKTQDLSLADHEVDGEAIPNGDATHEHDAEDDGDDGDDRHINGDATSVHTARSRPNVEEPSRSYVKPIPIVTTYEPDIPETTSVKHRSVAGSVKAPTQRGTSMRANSVRAPTKAETIRSPSRAASVRPTSIRKAESVRSLGPPASVKPSVRGSQRYSHLAEGAIGGAAVGEVVSSERQRELQQAGEQNHRGVALTDNGPIMGNHRPTSPFGYRPQPNIMSVTEDGRESRFDGRDSRQGLVNRSGTVVSRANTVGRSGTLSRAANGGTVGGRRGAFGRGAGASIGTQPEEVLGRDDIHTRAELSERILDDQTLRRLSTMERKDAKRLSRVIKNEGKAEAMAVKGSIKELERLSKLQREAAAAERHSQQRLAKWTTKEHKARLRFLKEKERYERIEGDLRNAENDYEERRDHAAGLTAQVAEKTQELDDLRGQKAADDRERAVKLLALKNPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPF4</accession>
    <name>A0A1Y1UPF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_615485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873696.1">
        <property type="nucleotide sequence ID" value="XM_022014728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPF4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPF4"/>
    <dbReference type="GeneID" id="33556536"/>
    <dbReference type="InParanoid" id="A0A1Y1UPF4"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="3">
        <location>
            <begin position="72"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="374" mass="40478" checksum="A4636F0A017CCD26" modified="2017-08-30" version="1">MPHAATNTIDSDIVAFANSNPPPPYPGSNQYDLTPTPYTQNRPRLPEERRNLHLTALPEDAKIVKFQTIVREGKEIVVGRIKVPTTGPNAHAFILRRYDTNAVSLTTMFKVAFPGATDEEERREMDWVRSSYDIRDTNGGRGCDAVRLAGQWVSRHLAIHLAPAYNISELVAALARAVPDPNVAYRKSQRSQAAAEEMSRQKPEVSARTNTVVPSMSNESASPAPKRQRRQSAQPVSDAVDTDAGSRHLTLEAVTTVTAPTGAQVDMEAEIQSAKQLVMDLKRELNLRAAAGEELEDQGADVAEGSRGTKRSKGSDEGVAISGGAGKDRIIRRSKRVEQTGVAQTARQVAWGALIFGLGVGAALSLPQLAAQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPK2</accession>
    <name>A0A1Y1UPK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor of RES complex-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873746.1">
        <property type="nucleotide sequence ID" value="XM_022017860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPK2"/>
    <dbReference type="FunCoup" id="A0A1Y1UPK2">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPK2"/>
    <dbReference type="GeneID" id="33559669"/>
    <dbReference type="InParanoid" id="A0A1Y1UPK2"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="358" mass="40389" checksum="DE9ADDCD6BBDC2F1" modified="2017-08-30" version="1">MSDLKTYLASRYMSGPKADAILARSTDPSVKKKRKKIKNEDYIGGSSVRPGESSSGAIVASGLGIRDEDEWRTRDDDEIDFDGEDAPVLGKDIATFKKSKNQWATVGASTIPVAGPSRTNGTSGDDSMTEVKQEPMDEPGTATAAAALPAVQMTKRRGGLRTAAQLREEEEALQAAERSPSPIDEKPGESSSGAGARPDPTQTIHRDASGRIIDVEKLKEEEKKRVEEEKRKEREKEEWTKGMTQRKEREERAREELEMRDKDVSRFADDAKMNKELKEVERWNDPASEFLTKKKKKQKGPRRPKCQFSMIPNRFNIAPGFRWDGVDRSNGFEKKFFQYQNAAARRTYESNQWSMEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPY5</accession>
    <name>A0A1Y1UPY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_648644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873817.1">
        <property type="nucleotide sequence ID" value="XM_022017867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPY5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPY5"/>
    <dbReference type="GeneID" id="33559676"/>
    <dbReference type="InParanoid" id="A0A1Y1UPY5"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="436" mass="46131" checksum="BBDD88BDFD15AC4A" modified="2017-08-30" version="1">MLRRKVSNGLLRATKSNSSLRATAQTQAQMVPPLPQTANFSTLIAKSVKVSEREWGKETVVTLKQELKMRGLPQTGKKADLVERLTMAGKAMPAASSSSTSTSQSSQILSKTAPLTAPKSVPSSSQVIAKPTAPASTPVSKSKTPTPVTPAKAKAPEMTPKTMAKAPEPVTPTPIYRLKGSGTTPSRATAPGPPQMTTPAAPRVSKMAMPPPSSFRMSTASPRLFSTSVVRPAAKKSTPEHSTVLDDHVVSTGPSVSSQKSEAPKAEKPSPEEVTTAPGLPKTKSAGESKGLNVKMPDPRPEPSHEQTIPLEPDNFKTAAKPKEEQSSNSGPKVMTVASASTHHAGGPSHAIHESADPTAVESSESLEENNKSSERSEGGTDKDGQYRAPERELNDEERRGLYIMGGIVGLGWLIGGPKKDKKKKKVETETKSEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ48</accession>
    <name>A0A1Y1UQ48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_587374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873946.1">
        <property type="nucleotide sequence ID" value="XM_022013753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ48"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ48"/>
    <dbReference type="GeneID" id="33555561"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ48"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000099">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="14"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="290" mass="30759" checksum="C2BF1CF63A4DBBFE" modified="2017-08-30" version="1">MSTKRVGGASANSMAAKRIKREIADLSKENLGNITLVPNESNIFAWKATIPGPQGSPYEGGVFEVDIRIPDDYPFSPPHLHFITKVYHCNVASSGAICLDLLKTAWSPALSLYKVILSLSSLLTDPNPSDPLVPAIAQEYKKNKAKHDQNARDWVKQYALPKNPPPPTTSSSSKPNPMPAQRPHPISRPNSSTSVPPAQVAGTRRSNPFSSDDGQETSGRDTSLANGTGSASAAINLVDSDSDGEAGGTSSRPRRGERAPKRPRTGVVGAAVGSSRTRATASDDVIVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ61</accession>
    <name>A0A1Y1UQ61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873429.1">
        <property type="nucleotide sequence ID" value="XM_022017816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ61"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ61"/>
    <dbReference type="GeneID" id="33559625"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ61"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05269">
        <property type="entry name" value="TMR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="295" mass="32163" checksum="681039818BA19784" modified="2017-08-30" version="1">MSFTIGVTGANGYLGSKTIQALLNHSLVPASSIIAICRDPSKASEASSRGVDVRQADFKDTPSLAKAFKGVHNLFIVSPNVLGDEGKQLTTNAIAAAKAVGVKKIFYTSHTGAREHTEFVPGSQHYHVEQKLKQSGLEWTSLRNGFYLSGTDYLYGKPIESGSITAPEDGKVSWVDRLDLAEASARILAEQYDTKGVEYLDLVNAKSWDMAEAAEILSKITGKEIKRNVVQDKTFVDSFVANGIPEPMAKMFSGTVKAMHNGDFAKTDGVLEQIIGRKPKTLDEYLEEKRDKTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQA9</accession>
    <name>A0A1Y1UQA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_648377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873532.1">
        <property type="nucleotide sequence ID" value="XM_022017829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQA9"/>
    <dbReference type="GeneID" id="33559638"/>
    <dbReference type="InParanoid" id="A0A1Y1UQA9"/>
    <dbReference type="OrthoDB" id="4689996at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="55" mass="5900" checksum="8D6A21335D59D818" modified="2017-08-30" version="1">MNLHHVASTQFEVSIPAVADGEYYFVATVPYVTGASGGVGFRTWNQTMSIIAPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQE9</accession>
    <name>A0A1Y1UQE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_577249</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873228.1">
        <property type="nucleotide sequence ID" value="XM_022013245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQE9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQE9"/>
    <dbReference type="GeneID" id="33555053"/>
    <dbReference type="InParanoid" id="A0A1Y1UQE9"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="74"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="229"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="400" mass="43223" checksum="5C8802131A4109A5" modified="2017-08-30" version="1">MHHHSGIEPTAVDGSPLLSRYEAYYDPKKVLNHPEFKILEDGAPELDDPKRNLACAYNQHKTVHMINKPIPVAGKNECIVHVKNTGICGSDVHFWKHGQIGPQMVVRDETGAGHESAGEIISVGEDVKDLKVGDRVAIEAGVPCGQADCDPCRTGRYNACPRVVFFSTPPYHGTLTRFHAHPAPWLHKLPDNVSFEEGSLCEPLAVALAAIERAGVALGDPLLICGAGPIGLVTLLASHAAGCTPIVITDLVASRLEFAKKLMPSVKTVLLNKEDDAQVNAQRVRDACGMMPRVAIECTGFESAINTAIYSVAFGGKVFVTGVGPLEQMYPFGYVNANEIDLQYQYRYANQYPKAIRLVSGGLIDLKPLVTHRIPLAKAVEAFHIAADPSQGAIKVQITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQJ4</accession>
    <name>A0A1Y1UQJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_641148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874027.1">
        <property type="nucleotide sequence ID" value="XM_022017399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQJ4"/>
    <dbReference type="FunCoup" id="A0A1Y1UQJ4">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQJ4"/>
    <dbReference type="GeneID" id="33559208"/>
    <dbReference type="InParanoid" id="A0A1Y1UQJ4"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="7">
        <location>
            <begin position="533"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117917" checksum="C734E38B77B36EB3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQZ8</accession>
    <name>A0A1Y1UQZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874187.1">
        <property type="nucleotide sequence ID" value="XM_022014237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQZ8"/>
    <dbReference type="GeneID" id="33556045"/>
    <dbReference type="InParanoid" id="A0A1Y1UQZ8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="2">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="778" mass="83921" checksum="4AF22B40B282000E" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR11</accession>
    <name>A0A1Y1UR11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_615952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873802.1">
        <property type="nucleotide sequence ID" value="XM_022014773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR11"/>
    <dbReference type="FunCoup" id="A0A1Y1UR11">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR11"/>
    <dbReference type="GeneID" id="33556581"/>
    <dbReference type="InParanoid" id="A0A1Y1UR11"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="85"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="12">
        <location>
            <begin position="288"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70862" checksum="71614FFF32FEF85E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR67</accession>
    <name>A0A1Y1UR67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_678025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874250.1">
        <property type="nucleotide sequence ID" value="XM_022018969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR67"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR67"/>
    <dbReference type="GeneID" id="33560778"/>
    <dbReference type="InParanoid" id="A0A1Y1UR67"/>
    <dbReference type="OrthoDB" id="2524557at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="96"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="60842" checksum="D473153340F8D097" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URR0</accession>
    <name>A0A1Y1URR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin-14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874420.1">
        <property type="nucleotide sequence ID" value="XM_022017696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URR0"/>
    <dbReference type="STRING" id="4999.A0A1Y1URR0"/>
    <dbReference type="GeneID" id="33559505"/>
    <dbReference type="InParanoid" id="A0A1Y1URR0"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23562" checksum="1B6C7A6C1B668A63" modified="2017-08-30" version="1">MSELDEQTLALKAARARPLTALQPRPSTIIPFLRRLTFIVSLLLGSAAATSWIWSTFLLPLLHATFSARNALVEQQSEKVTQLLESIKEIRSRQIWRKPDAEEALDDESFSSSTSLHSHPASTPLPLESLTTLSTQLRSLASAVDSTSTTRTSLLSTLEMFTSQLHDTTLRSVHSSSFSTDSPRSEEWKAVRNEIRGMKGILLGRRNFAQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US12</accession>
    <name>A0A1Y1US12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_617093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874041.1">
        <property type="nucleotide sequence ID" value="XM_022014877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US12"/>
    <dbReference type="STRING" id="4999.A0A1Y1US12"/>
    <dbReference type="GeneID" id="33556685"/>
    <dbReference type="InParanoid" id="A0A1Y1US12"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011825318" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="46"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="550" mass="60138" checksum="7F511503A32C8F23" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US62</accession>
    <name>A0A1Y1US62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_610845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874146.1">
        <property type="nucleotide sequence ID" value="XM_022014223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US62"/>
    <dbReference type="FunCoup" id="A0A1Y1US62">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US62"/>
    <dbReference type="GeneID" id="33556031"/>
    <dbReference type="InParanoid" id="A0A1Y1US62"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012711290" evidence="6">
        <location>
            <begin position="20"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="266"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="581" mass="60461" checksum="A9CF590B73AC91A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USF3</accession>
    <name>A0A1Y1USF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_647492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874246.1">
        <property type="nucleotide sequence ID" value="XM_022017668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USF3"/>
    <dbReference type="GeneID" id="33559477"/>
    <dbReference type="InParanoid" id="A0A1Y1USF3"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012824432" description="V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="8">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="281" mass="30488" checksum="5E086EB89262E625" modified="2017-08-30" version="1">MRIQTSLAAAAAVAVLPASVYGFKETSPLYVWSSSSDHISAFQAKSSILSADEAYASISKLGCDWTNLVVAYSEGIHQSHVSSLKLQSSSPTAHVPYVKSLDQPSLRAAINELFSSCSDDGRERSMMWRIVPNNSNLETAMEALPENDLLILTGTPTSPSKRQEYPFPSPSPSPSPSPDDPEDPEDPEDPEDPEDPEDPDVPQRPSPEPGEPSDTPVPSNAPLLQRAQFFTAPIITGLLVTFLVFIPFLYLGITALVSIEVPPRMLEIGKSLVVTKDRKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USK2</accession>
    <name>A0A1Y1USK2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA helicase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_29130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874611.1">
        <property type="nucleotide sequence ID" value="XM_022012393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USK2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USK2"/>
    <dbReference type="GeneID" id="33554201"/>
    <dbReference type="InParanoid" id="A0A1Y1USK2"/>
    <dbReference type="OrthoDB" id="2589460at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="364" mass="40941" checksum="0558328105920DB8" modified="2017-08-30" version="1">MDFQDFDGASNYTFDRDEVTSVWSAMPTSQAHHDVPADLQSMVDDLTLDSTSHVNGHGHLEEDEEELGYNIEHACSYCGIHNPQSVVKCLHCSKWFCNSRGNTSASHIVNHLVKAKHKEVILHKESALGETIPECYNCGSKNVFMLGFIPAKSDTVVVLLCRQPCAALTNAKDINWDTSQWSAIIDDRSFLSWLVKVPSEVEQLRARQISMAQIAMLEDLWRDNPQARLEDAEAQVGEEEMQPILMRYEDAYQYQNIFGPLVKIEADYDKKMKESQTENDITVRWDMGLNQKRLAWFSMPKLESGEVRLAVGDELRLKFVGATTGLAGMKGLQALRGGQETVWEAVGSVIKIPNSEHDPLPRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UST2</accession>
    <name>A0A1Y1UST2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_611813</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874376.1">
        <property type="nucleotide sequence ID" value="XM_022014311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UST2"/>
    <dbReference type="FunCoup" id="A0A1Y1UST2">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UST2"/>
    <dbReference type="GeneID" id="33556119"/>
    <dbReference type="InParanoid" id="A0A1Y1UST2"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="283"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="635" mass="71097" checksum="83242B135BA89A92" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT72</accession>
    <name>A0A1Y1UT72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Surfeit locus protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_613655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874890.1">
        <property type="nucleotide sequence ID" value="XM_022014522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT72"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT72"/>
    <dbReference type="GeneID" id="33556330"/>
    <dbReference type="InParanoid" id="A0A1Y1UT72"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="153"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX41211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="40583" checksum="2409363A80808BA8" modified="2017-08-30" version="1">MASAMMSNGHAPDLLASLERHNESFTKLLSLIPSRFYAAPESQEVDSKWMKKKKRQTGEEIKEQKKKARQDKFDPSKQSTAADLVNSSSQAGPSSIPLPISSPALPAPVRPLPPTASISDLRARLHSKIEGFRRDRGVDDDADPQSRSALEAETRRRRGEMRDRRRRERKEERRKAREKEAVTGKSAKPRLVVPHPRDNDGVTYPTVKLPSAAQHKSNFKPIANPSHALAHLEKHKRKLDSMTDEKRREVLERERWAKAEERAAGGKVADQETVLKKAVKRKEKEKSKSGKEWSERKRDLERAQAASIKKRSDNIAARADAKRNKKLGLKDKNKGGKMKKKGRPGFEGGRNKNKQKDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT78</accession>
    <name>A0A1Y1UT78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_613760</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874908.1">
        <property type="nucleotide sequence ID" value="XM_022014533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT78"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT78"/>
    <dbReference type="GeneID" id="33556341"/>
    <dbReference type="InParanoid" id="A0A1Y1UT78"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="14">
        <location>
            <begin position="187"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX41229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="390" mass="44192" checksum="84B21AE192CD8D52" modified="2017-08-30" version="1">MKRNNFTLLYSYKTLETLLIYQSLSDIVKLVIMEAGNLEECMKLHSMTGAQAQTAMPSLDGLKWLDDDEQVGCIKRVGYEQGIPLLHTRAFHFWLGQRHPLKQWTLAPEDWTIKSASESNYHISYHLEHCRHVVPSEHQRRVFLLGKRPEYFEGDEYVWPQGALAEITTTLPGGVEFIATAGKGGGELPEAGIRNVGLLDKEEWFKLVAESSVMLGIGLPRSSPSAYDALCLGIPFINPSVCMVNPFAEVSRITKLDRKHPDDRTKWILQQDPLRNEDPPYVYNIEAGNTEELRKAIQSALDTPIEPYIPERMTIEFVERRLLYLFSEDWREIALEQIKSSETGLGFATSDGKNVGVQSQSLFPKTSSELIWFPSSSIHRASQASCFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTA1</accession>
    <name>A0A1Y1UTA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_648121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874920.1">
        <property type="nucleotide sequence ID" value="XM_022017785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTA1"/>
    <dbReference type="FunCoup" id="A0A1Y1UTA1">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTA1"/>
    <dbReference type="GeneID" id="33559594"/>
    <dbReference type="InParanoid" id="A0A1Y1UTA1"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="142"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX41241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="61324" checksum="9B6B5E78A8803B51" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTT7</accession>
    <name>A0A1Y1UTT7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative signal recognition particle binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_612626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874623.1">
        <property type="nucleotide sequence ID" value="XM_022014413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTT7"/>
    <dbReference type="FunCoup" id="A0A1Y1UTT7">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTT7"/>
    <dbReference type="GeneID" id="33556221"/>
    <dbReference type="InParanoid" id="A0A1Y1UTT7"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="685" mass="73556" checksum="3AE3F985B5CAF3FD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTW0</accession>
    <name>A0A1Y1UTW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">BD324DRAFT_640544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTW0"/>
    <dbReference type="FunCoup" id="A0A1Y1UTW0">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTW0"/>
    <dbReference type="InParanoid" id="A0A1Y1UTW0"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="326"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="501" mass="53659" checksum="ADB9F5A6288FE621" modified="2017-08-30" version="1">MKDTYDIVIIGGGNAGLALACALLDQPSIRGTSRILLLEGGSLDRVRGWKGDGAWENRVSSLTAENVAWLDRIGVWQYIAKDRTCPVNEMVIWSNPTPGQTPSIHFPPLGYPMAHMTENTNLQRALLRRIDEAGKGIVDIREGSRVGEMRLGEGERWIGLQVGDSWVRGSVVVGADGFNSPVRKFSAIESYGHAYPTHAIVATLEHPPSSVYPNNTAFQRFLPTGPIAFLPLSATASTLVWSTHPTHAAAYRRLSPEALTHMVNAGYTMQERPLSDLNEKILSADASGSPLDCETIKGLISTINISGGSLTSEEVILPPAVQAIPAKSIASFPLRLSHADEYIGNRTVLVGDAAHTTHPLAGQGLNMGLADVRVLSEVWEQVKRKGGDIGSKIDCAEYPKQRYPANQLLLTTTDTLHHVFASRSGPINWARGVGLDVINEIGPLKKALMENAGALPPRAAPTQHNGWGATAATGLEGWIGLKGAVAAGLGLLGDTLRRTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU65</accession>
    <name>A0A1Y1UU65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874856.1">
        <property type="nucleotide sequence ID" value="XM_022017773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU65"/>
    <dbReference type="STRING" id="4999.A0A1Y1UU65"/>
    <dbReference type="GeneID" id="33559582"/>
    <dbReference type="InParanoid" id="A0A1Y1UU65"/>
    <dbReference type="OrthoDB" id="3235770at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF2">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="619" mass="69534" checksum="0F6CC5881C7C13BD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU66</accession>
    <name>A0A1Y1UU66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX40725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874404.1">
        <property type="nucleotide sequence ID" value="XM_022017692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU66"/>
    <dbReference type="GeneID" id="33559501"/>
    <dbReference type="InParanoid" id="A0A1Y1UU66"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="170" mass="19047" checksum="9824583C01918EB4" modified="2017-08-30" version="1">MSSRDPPAGFKRETWRPQPTSSWTPRQTDSFRPEAITNLGLQDIMMIRASPPEARHTGTEVLEMIDSETSRDGNAAMMRDGMITGDREKEMGRGERMVDPLRQVHEEEPLVCLMEVEDGVEEARTIDRRSPIETTGTAGGLQLGVIKILTDLLVLRLQNDRAGEIVQTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5H8</accession>
    <name>A0A1Y1U5H8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_585253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867636.1">
        <property type="nucleotide sequence ID" value="XM_022013732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5H8"/>
    <dbReference type="GeneID" id="33555540"/>
    <dbReference type="InParanoid" id="A0A1Y1U5H8"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61502" checksum="E10F936D278F3729" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5I3</accession>
    <name>A0A1Y1U5I3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_288693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000028">
        <property type="protein sequence ID" value="ORX33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867644.1">
        <property type="nucleotide sequence ID" value="XM_022012388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5I3"/>
    <dbReference type="GeneID" id="33554196"/>
    <dbReference type="InParanoid" id="A0A1Y1U5I3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="546" mass="62247" checksum="379699A146A2CEA8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5R3</accession>
    <name>A0A1Y1U5R3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000023">
        <property type="protein sequence ID" value="ORX33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867707.1">
        <property type="nucleotide sequence ID" value="XM_022017311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5R3"/>
    <dbReference type="GeneID" id="33559120"/>
    <dbReference type="InParanoid" id="A0A1Y1U5R3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="128" mass="15124" checksum="2D149DCE36053630" modified="2017-08-30" version="1">MHNEEEDRLREEARQALALLEQHRRLNSEERVRKEIEMVNIVTNERSARRACEEELSQAKESVEALTSRVRQLQIEQREQEARNALRDQDKAELEIAKLKQMTLSGGDHPSDNLIRQAIKYRRAYQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5T2</accession>
    <name>A0A1Y1U5T2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000022">
        <property type="protein sequence ID" value="ORX33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867737.1">
        <property type="nucleotide sequence ID" value="XM_022017306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5T2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5T2"/>
    <dbReference type="GeneID" id="33559115"/>
    <dbReference type="InParanoid" id="A0A1Y1U5T2"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="243" mass="27361" checksum="AE937B5357CC3A95" modified="2017-08-30" version="1">MTSWLRYTENHTSQSKRKSTLSDRNLQHQSPHSLSPPSLPHSPHVQTPYLDPWLASVPDHLTEVVFAQSTPLPCSWTPGRPQYPPEILSPTPRRYIMDQLNPLGNSWRSDEYSLKGKEKEERWNMVPSMRQTHSGLPDDSTRLEPSTGPWDAPKRAFTHDKAHGSSGSRGPGSIRIGPLPSAILASIMDTSAGRDKVLKTIQYTLKTYLYLLSLIARVRPLSIWFKANSKRMKIATGSLSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U630</accession>
    <name>A0A1Y1U630_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867787.1">
        <property type="nucleotide sequence ID" value="XM_022017287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U630"/>
    <dbReference type="STRING" id="4999.A0A1Y1U630"/>
    <dbReference type="GeneID" id="33559096"/>
    <dbReference type="InParanoid" id="A0A1Y1U630"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="18817" checksum="0C5D6EF4BF088B8C" modified="2017-08-30" version="1">MLGSWFPDVGPEPILLTWSGGTAPYILSIIPGGDTSSAPLETLVSDTSDTSYTWTVNLAAGTEVNIKVTDNTGVSQYSSQKDILSGGSSSCLNSTATSIAGAAGATTGATSAASSSSTGSSGSSTSSSMGSMTSSMSSMASSSMGSSTSGSSASSTSSSSSSSSSKAATTSGAAFKKYEAPAALLAIFGGIAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U656</accession>
    <name>A0A1Y1U656_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ER to Golgi transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_639652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867848.1">
        <property type="nucleotide sequence ID" value="XM_022017259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U656"/>
    <dbReference type="FunCoup" id="A0A1Y1U656">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U656"/>
    <dbReference type="GeneID" id="33559068"/>
    <dbReference type="InParanoid" id="A0A1Y1U656"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011006378" evidence="9">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="215" mass="24498" checksum="B54C51CF71D12E90" modified="2017-08-30" version="1">MRLHPTLALLAVLNVASALHFYFESHEKRCFLEELPSDTIVEGHYRALVWNEERKEWGGKEGMGIQVEVQELASGHNVVNTRGPPEGKFTFTSHDSGDHEICLHSNVSSGSWIGGSEHIKMYLDINVGSSKKDMSDDVSHVTTLATKIRDLNTKVKEIQLEQKYMREVEATFRDASEKTNSRAVWWSIIQIVVLVGAAFGQMRYLRTYFEDKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Q1</accession>
    <name>A0A1Y1U6Q1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_666297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867998.1">
        <property type="nucleotide sequence ID" value="XM_022018915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Q1"/>
    <dbReference type="FunCoup" id="A0A1Y1U6Q1">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6Q1"/>
    <dbReference type="GeneID" id="33560724"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Q1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03775">
        <property type="entry name" value="MATH_Ubp21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="190"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1106" mass="126968" checksum="46B852E401DCA8C6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U749</accession>
    <name>A0A1Y1U749_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_654206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000023">
        <property type="protein sequence ID" value="ORX33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867713.1">
        <property type="nucleotide sequence ID" value="XM_022018767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U749"/>
    <dbReference type="GeneID" id="33560576"/>
    <dbReference type="InParanoid" id="A0A1Y1U749"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="262" mass="29789" checksum="919301D7EDE40CEC" modified="2017-08-30" version="1">MITRSRQASIQPDESTPAEGSAPKAYSMSKSAVASRIYRSRFPPPPEPYREPAAWAQPTGRRKAKGARRQRAPTSMTSTTSLAPERQRTDKRREQLYRNGQGGFNDQDRNFREGWEELNLGDSHAVTRPPRGRRDYDLSPERERGREREEEDDQNASNFHHLSPIDLDLNRLSDMENGMEGPNFDFPPDDEPLPHHLRGPERVDAPQGAFTPRILPPSNSHGPLPSTPQEKIGQSTRDSRQTRDYPLTPTSSQAVAIRYMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U773</accession>
    <name>A0A1Y1U773_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_640077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000024">
        <property type="protein sequence ID" value="ORX33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867694.1">
        <property type="nucleotide sequence ID" value="XM_022017315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U773"/>
    <dbReference type="GeneID" id="33559124"/>
    <dbReference type="InParanoid" id="A0A1Y1U773"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="91" mass="9686" checksum="8931F343A2A8CB35" modified="2017-08-30" version="1">MSLMSRFWAIGDALVRFLTGVAPLRSSNGSVWVVRMHEPSLGGKGTINSYIMYKTVVPGASPRTQGSPQTSQQPADPGHSKGVGGWENAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7N8</accession>
    <name>A0A1Y1U7N8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_194139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868337.1">
        <property type="nucleotide sequence ID" value="XM_022012143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7N8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7N8"/>
    <dbReference type="GeneID" id="33553951"/>
    <dbReference type="InParanoid" id="A0A1Y1U7N8"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013050462" description="Glycosyl hydrolase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20594" checksum="FAF1959E4C2C27AF" modified="2017-08-30" version="1">MLRTVACLLWLSLGIVRAVTFTNPIRSNAPDPFIVWDGDTQRYWFTWTTGKRLRLLSASTISELKEDPTQVSTYQTPEMDQKGTMWAPELHKIGSKWYFHWSLAQIPYVMEIGSKDPEGACGSTRAAWVEKIDTSSIVPVLPPVGVLGESLEGPSGEKSVGEMVFGVERNSTCGAKRRRSMVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Y9</accession>
    <name>A0A1Y1U7Y9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868401.1">
        <property type="nucleotide sequence ID" value="XM_022016927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Y9"/>
    <dbReference type="GeneID" id="33558736"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Y9"/>
    <dbReference type="OrthoDB" id="2563275at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11573" checksum="92164724509F00D5" modified="2017-08-30" version="1">MSSSQSPKLPAAPVAPPAPVSVSGSNLTGPNAFQSVLPMVDNLLSIISSQITSANPPTGIQAAEAVTSEAKELALALGRMKTAAQSLPGGEYNTSQVEEMISVLKKEAERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U853</accession>
    <name>A0A1Y1U853_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_584669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867987.1">
        <property type="nucleotide sequence ID" value="XM_022013696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U853"/>
    <dbReference type="FunCoup" id="A0A1Y1U853">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U853"/>
    <dbReference type="GeneID" id="33555504"/>
    <dbReference type="InParanoid" id="A0A1Y1U853"/>
    <dbReference type="OrthoDB" id="2585648at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="103" mass="11409" checksum="AC4F0A498DB0C948" modified="2017-08-30" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDSVTYTEHANRKTVTSLDVVYALKRQGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8R5</accession>
    <name>A0A1Y1U8R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_637601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868174.1">
        <property type="nucleotide sequence ID" value="XM_022017023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8R5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8R5"/>
    <dbReference type="GeneID" id="33558832"/>
    <dbReference type="InParanoid" id="A0A1Y1U8R5"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18610">
        <property type="entry name" value="GH130_BT3780-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106:SF5">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012688685" evidence="4">
        <location>
            <begin position="17"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="392" mass="44078" checksum="20357FCC71CBA4D3" modified="2017-08-30" version="1">MLVLSLLLLSLVRAMSQSASKLPFEISPSTRSGDPNHIPPTFPIAPFHKYSGNPILRPEPDHKFEEAFLYNPTAIVLDDTVFILYRAQNKELQSSIGLAWSKDGVNFTRLDHPIIAPTEKYELPGGCEDPRIVRVNGTFYVTYTAWDLVEPQLALAYSDDLVNWTKVGLVFPGIMDVDMIDSDVRVPRFNHSKSAAIINEPDSKGQYHMYHGESLIYHAVSTDMKHWKPDPVTTYFASPAHPWEARLMEPGPAPIKTRDGKWILFYNGVADGRAGYTRGSYSTGQMLIDPEIGNKPAKIDHKTGKERPEARNGPIARLERPVLVPDAENEVEGQVNQVVFTEGLVQFKGKWYLYFGQADSELGVAIADVEPWHKEEDKHIFQKTYGQKVMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8R9</accession>
    <name>A0A1Y1U8R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_150777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868703.1">
        <property type="nucleotide sequence ID" value="XM_022012024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8R9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8R9">
        <property type="interactions" value="920"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8R9"/>
    <dbReference type="GeneID" id="33553832"/>
    <dbReference type="InParanoid" id="A0A1Y1U8R9"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="866" mass="94261" checksum="5C4CBE46885F39B8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8X5</accession>
    <name>A0A1Y1U8X5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exocyst complex component Sec10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_653266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868752.1">
        <property type="nucleotide sequence ID" value="XM_022018636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8X5"/>
    <dbReference type="FunCoup" id="A0A1Y1U8X5">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8X5"/>
    <dbReference type="GeneID" id="33560445"/>
    <dbReference type="InParanoid" id="A0A1Y1U8X5"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="8">
        <location>
            <begin position="74"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="7">
        <location>
            <begin position="214"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115958" checksum="AB54F4B916D6F2F9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U954</accession>
    <name>A0A1Y1U954_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_610123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868824.1">
        <property type="nucleotide sequence ID" value="XM_022014191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U954"/>
    <dbReference type="STRING" id="4999.A0A1Y1U954"/>
    <dbReference type="GeneID" id="33555999"/>
    <dbReference type="InParanoid" id="A0A1Y1U954"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="522" mass="60531" checksum="047C3ABF7CAB7A3C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9D1</accession>
    <name>A0A1Y1U9D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_634307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868880.1">
        <property type="nucleotide sequence ID" value="XM_022016710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9D1"/>
    <dbReference type="FunCoup" id="A0A1Y1U9D1">
        <property type="interactions" value="925"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9D1"/>
    <dbReference type="GeneID" id="33558519"/>
    <dbReference type="InParanoid" id="A0A1Y1U9D1"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="157"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="347" mass="39965" checksum="9A376596246A5296" modified="2017-08-30" version="1">MPPKVKDDKTFGMKNKKGAKVQKYIATVEKQASASGKNKQDIAKEKEKQARVEAKKAEEAKKKLDAELFRTAIQVQKVPFGTDPKTVLCAYFKAGYCEKGNKCKFSHDRNVERKVEKVNIYEDARDKDADKKEDLMENWDEDKLRKVVNQNSMKQKMTTDIVCKYFVQAIEDKKYGWFWECPNGGDKCHYRHALPPGFVLKSERKAKEELDKKNEISLEDFLEVERHKLKPPLTPVTAESFALWKKNRLEKKQAEQEAMEKAKAVQRAAGKLTGMTGRDMFTFGGEIYEDEDEGDEDWDISRMLARYREEDERPEDENQPNEGIRGDDEDEAEEAANGVDKLSVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Q9</accession>
    <name>A0A1Y1U9Q9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_593813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868994.1">
        <property type="nucleotide sequence ID" value="XM_022013824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Q9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9Q9"/>
    <dbReference type="GeneID" id="33555632"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Q9"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="354" mass="39463" checksum="A9ED6D776E2478A1" modified="2017-08-30" version="1">MSSFQFGHFGYICERAALTICPLVGTDLGVMPTCYSRNVQLGSQIIFQPATCFVHIAALAMTLIMLFHVRSKYTAVGRKEIVLFFYLYMFVELLAIFLDSAIIPTAHQVYPWFAAVYAGALGALYWCILINGFVGFQFHEDGTPMSLWFLRLSCLAIWGICFFIAIATFKGFVSFSFTKPIGLFITYLMFPAVCVLIYVVSQLVLVIRTLDDRWVIGDIIFGTAFYVVGCVLLFAFSVKICDAVSHYIDGVFFFTLCMLLAVMMVYKYWDSITKEDLEFSVGSKQAVWEVKDPLLPAGSEYAMEDDQQSQFRGAGGSLIFGGGGNTMYAPSIQYSQHQGAYGNGHNGGYNNGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA76</accession>
    <name>A0A1Y1UA76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative high-affinity glucose transporter of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_652651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869145.1">
        <property type="nucleotide sequence ID" value="XM_022018529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA76"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA76"/>
    <dbReference type="GeneID" id="33560338"/>
    <dbReference type="InParanoid" id="A0A1Y1UA76"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="35"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="574" mass="62858" checksum="36509EA1D3993FEB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAC5</accession>
    <name>A0A1Y1UAC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_582447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869217.1">
        <property type="nucleotide sequence ID" value="XM_022013557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAC5"/>
    <dbReference type="FunCoup" id="A0A1Y1UAC5">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAC5"/>
    <dbReference type="GeneID" id="33555365"/>
    <dbReference type="InParanoid" id="A0A1Y1UAC5"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="695"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="762" mass="83159" checksum="C32BFA8BF51E34D9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAQ6</accession>
    <name>A0A1Y1UAQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_652834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869336.1">
        <property type="nucleotide sequence ID" value="XM_022018562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAQ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAQ6"/>
    <dbReference type="GeneID" id="33560371"/>
    <dbReference type="InParanoid" id="A0A1Y1UAQ6"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="234" mass="26081" checksum="DB326A652BE8CEFE" modified="2017-08-30" version="1">MGLGPVHCGSFFLFCAFALLLIATISSPIIKQIGFLNIHYNGETSRFGTFGYCLDGVRECSKSKLGYDLTRITGAGLDYRWTNETLNGSTKALILHPIAMGIAFIAFLITLVSDHVGFIFAAFITFLAFIVSLVAMIIDFAVFGIVKREVNDHTNAVAKYGVTTWLTLAATIVLFFSVFIVFFSCCTHRKNHRKEYDNSYNNAGYVGNEGTAYGTKQPWHKRFFNRNKNANGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAR6</accession>
    <name>A0A1Y1UAR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_633983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869346.1">
        <property type="nucleotide sequence ID" value="XM_022016686.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UAR6">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAR6"/>
    <dbReference type="GeneID" id="33558495"/>
    <dbReference type="InParanoid" id="A0A1Y1UAR6"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1564"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1885" mass="207211" checksum="0CD6B251212A04DB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAW2</accession>
    <name>A0A1Y1UAW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_634481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868926.1">
        <property type="nucleotide sequence ID" value="XM_022016734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAW2"/>
    <dbReference type="GeneID" id="33558543"/>
    <dbReference type="InParanoid" id="A0A1Y1UAW2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="74" mass="8751" checksum="D59AA7CB530D3875" modified="2017-08-30" version="1">MIRIPLLFDKEQNSNTLLPFSLAFLISVLSSAFPPWVSARMSPKEKRKRERGWFTKRERAKGKKRVTPMTRFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBP6</accession>
    <name>A0A1Y1UBP6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Scd6-like Sm domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_633137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869122.1">
        <property type="nucleotide sequence ID" value="XM_022016599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBP6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBP6"/>
    <dbReference type="GeneID" id="33558408"/>
    <dbReference type="InParanoid" id="A0A1Y1UBP6"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lsm14-like N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="FDF" evidence="2">
        <location>
            <begin position="182"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="38639" checksum="4B6C474775422A09" modified="2017-08-30" version="1">MAGVDYSQYQGKPFQVISKLGVRYTGIFDHISQEKQTICLAKVFNHGTEDRPVAKKFPPNPKSLGWVQFHTASIEALALVEDYVPPYAVPDDPVDPILASVSATAPSSSAPPPPPPTSQSSSQPAPSAAPSQPSSQRHNLPAKPPASSASTALDRVQHSLSELSTSDNTRRRPSQPPARPIEVPDADFDFSKGTEKFEAEREARKGQDAEGGDGEGGEEAESKAPDEQAIEQSNGHGATAGQLKDGDAKKSSVYNKSSFFDGLSASTSRVGRNEERGRNLDTFGEAGDGGFGSGMSGRGRGGFRGGNRGTPGPRGRGGYQGGGGGGQYGGYGSGGQYGGYGGGRGGSNGGDWRGGGRGRGRGGFSQGAPGGGLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBX2</accession>
    <name>A0A1Y1UBX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869705.1">
        <property type="nucleotide sequence ID" value="XM_022016341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBX2"/>
    <dbReference type="GeneID" id="33558150"/>
    <dbReference type="InParanoid" id="A0A1Y1UBX2"/>
    <dbReference type="OrthoDB" id="2564873at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="439" mass="49216" checksum="659A437A5F7B38A4" modified="2017-08-30" version="1">MLCSHAFIPRRTRSHTRMTMDTPPSCLLDSFCWSTAGQGDKGRRRGPVRVGFLSPKEAWSGRLKGVSKYQLRDGPLGYDERWFSNQVSDPENDFSQCRRGPIMAHSRIPDPVSREETDVRGRLRTDASRARNKGPTSEHGERRQDDSSICPWPSAVQSAFPLESIRLPFASTPPAPSSSYPARLRSFGGAFDQPNGSGGHDFEDECTDIRFRRFEGELLKPDVESSDWANTASDQHEILHTSERLEWQPDPDSLGRDEADEVWKAMERRLGRPVRDFTRRERGRWVLVKQKSGVITGYETPEESDTFHTALDSETANETGPQKVIATSGSHQPFPEDASGPLSTTRSRRSLQREERVRPIRSSHHRHASSIRRLDPLIVQALGRLDPDFDTPSLTLALSTPLVHAVPLRSTMKQSLCAESGLGLGLAMRSDSVYRLASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC03</accession>
    <name>A0A1Y1UC03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C3HC zinc finger-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_630730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869742.1">
        <property type="nucleotide sequence ID" value="XM_022016359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC03"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC03"/>
    <dbReference type="GeneID" id="33558168"/>
    <dbReference type="InParanoid" id="A0A1Y1UC03"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="29035" checksum="EF66AC72FA804D89" modified="2017-08-30" version="1">MSDHDLDPDLSDVFRSLYGGEDWAFDDDEPSEALVPDVEVVERDLELTDQRYTREYFRSNLDSLLDHRTGSTSRIYPAVRTFNTIVSSTEPIPSGPSGCYAPYSHLSLLNRLQTYTTSTFSTHPPPLSPVTLALHGWRNDGRETLTCDACQGSWNLLALEEIRDGNVRAEVARRLGKGLQTRHLPSCPWRAKRTPDDVYATIRTSLHPLALQSLAALVNSLEPNVPPGLRYISPLVSVLERACRLTLVPDPGIHTRHTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC31</accession>
    <name>A0A1Y1UC31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869303.1">
        <property type="nucleotide sequence ID" value="XM_022018554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC31"/>
    <dbReference type="GeneID" id="33560363"/>
    <dbReference type="InParanoid" id="A0A1Y1UC31"/>
    <dbReference type="OrthoDB" id="2592750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="384" mass="40753" checksum="EE44BD1372388069" modified="2017-08-30" version="1">MSDSSDLPAAPPPTLIMTDGSTAKSYNRHFLLSLATPQARPPNPERVRSFSQLLRNDSCQWGVDENVSTILGGCISPAESTGSTVASLSGPKIQKAVGGPAEILFNFKSPEQTPPVLVDFTVPNPFDNKSLSTNASSATPRMAPEFKASNVFQSFPGSKCPSQGSLSAAEDGPAHAQSFGDTFKTLRLGARLDSMDFARSRSSSITMSDDTGRRASRLSSISSNAGQRPLNAFAAPWPLPKTTPTIHLSKSRGSSIASSPIDGQTLPLPKPSSLPSSLPAKPNTVLPPVFVKRETAALPQSMALPDIAPLGKDWEGENSLSGNDKRRRASEMGFAPLPLPRDSLIQGLVGKKSLEVKPARPERLVKMGQNWRASVSAQGQEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC51</accession>
    <name>A0A1Y1UC51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_602957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869784.1">
        <property type="nucleotide sequence ID" value="XM_022013953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC51"/>
    <dbReference type="FunCoup" id="A0A1Y1UC51">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC51"/>
    <dbReference type="GeneID" id="33555761"/>
    <dbReference type="InParanoid" id="A0A1Y1UC51"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="12">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52761" checksum="DCDBFF86CCF92407" modified="2017-08-30" version="1">MASTSSRPIVIHTTPPLQPLPASDAQSIYYIALFQLACPGRWAATVADWADNGGALPYITHLDHLIQPHHLFSLPNFTHPDEHLSSTQRAEAECWTAFIHGKVTDLVHHSLYSLPHNYSASVGKAHLSNLTFPTSQYIPQRLRGMHKARLQHVGLWGLGGMNENDLAVEDQKRLENLYVTAPGGTVAPRAWNGWKSGREFEDRRRKVGENELRNILRNAMDPLKRLLGNKPYFYGERPCSIDLWLFANLSLIITTSLPNPIFADLLRAEYSGLIHHHDRLLQLLFPVTSESRSSNYVSSWNQTPTITSSTPKLSLWQTIQASLTWSSSPAEASPTSSRTEKKKLNKSERDFRRARWLWYAGALGSMVVYLFASGLIQIEYVGKEEEDSMEEIEDEEEELSDDDEELVLDPEEEEDIIIVVEPEEELESADVEPDQEGPNPAPNEEGLEDIAEEVAEDIENPYNDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCF4</accession>
    <name>A0A1Y1UCF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_634847</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868997.1">
        <property type="nucleotide sequence ID" value="XM_022016762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCF4"/>
    <dbReference type="FunCoup" id="A0A1Y1UCF4">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCF4"/>
    <dbReference type="GeneID" id="33558571"/>
    <dbReference type="InParanoid" id="A0A1Y1UCF4"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX34755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="513" mass="56780" checksum="52C9A88E97571C17" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCK1</accession>
    <name>A0A1Y1UCK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_582004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869937.1">
        <property type="nucleotide sequence ID" value="XM_022013537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCK1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCK1"/>
    <dbReference type="GeneID" id="33555345"/>
    <dbReference type="InParanoid" id="A0A1Y1UCK1"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="84"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="422" mass="45154" checksum="5248A7D522C3849A" modified="2017-08-30" version="1">MRQRLVSQGLKYIQWRSASTAAARAPPKSAGPSSPPPPEAEPSVGQSSLLLQEPAEALATKGLTFADGHGLKGPNGRGREVRRMNLHQAIRDALGTALATNPKSIVFGEDVETGVFRCTLGLMDEFGKQRVFNTPLTEQGIAGFAIGYASIGGSAIAEIQFGDYIFPAFDQIVNEAAKQHYASGGGYPLQGGSLTIRAPIGSVGHGALYHSQSPEGFFLGAHGLKVVIPRTPIQAKGLLLAAVRDPCPTLVLEPKILYRAAAEMVPVDDYTLPLGDIDVLREGTDLTVLSYGTPLYTCQRAIELLVNPPASLIPFLPARLRPPNPAPSIQLIDVRCLNPLPLNSITEAVRKTGRMVVVHESGKSGGAGNNIAGEVARRAFDHLEAPIALVSGWDTPVPLAFERFYQPDVIRIFDKMVETLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCK6</accession>
    <name>A0A1Y1UCK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_631673</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869944.1">
        <property type="nucleotide sequence ID" value="XM_022016452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCK6"/>
    <dbReference type="FunCoup" id="A0A1Y1UCK6">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCK6"/>
    <dbReference type="GeneID" id="33558261"/>
    <dbReference type="InParanoid" id="A0A1Y1UCK6"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="347" mass="37669" checksum="EE58EC3E2E0414C5" modified="2017-08-30" version="1">MHTDPYVAPPLDVSSVIHGGIHHPVLRSYQDQGRSLNKSMLMYPIFISDDPDAEQVISSLPGQKRWGINKLEGFLGPLVSKGLKSVILFGVPEKMIKDERGSAADDPNTPVILALKHLSALFPHLFLAVDVCLCEYTSHGHCGIQSSLPHPAHSNAPSLDADASAQRIADVAVAYAKAGAHCVAPSDMMDGRIRAIKMGLIHSGYGNRCTLMSYAAKFASGLYGPFREAAGSTPMFGDRKCYQLPPNGRGIARRAVRRDISEGADIIMVKPALPYLDVISDAQEIAKDLPIACYQVSGEYAMIYAGAEKGIYDLKQMAFETTESMVRAGAGIILSYFTPEFLDWLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD12</accession>
    <name>A0A1Y1UD12_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869596.1">
        <property type="nucleotide sequence ID" value="XM_022016546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD12"/>
    <dbReference type="GeneID" id="33558355"/>
    <dbReference type="InParanoid" id="A0A1Y1UD12"/>
    <dbReference type="OrthoDB" id="2574639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="180" mass="19217" checksum="77644E2AB558CFA1" modified="2017-08-30" version="1">MLSSARRTFTFFLQTPLIPPPAPQPTFELSNMSSSTSAGPSRPVQASRTFSSFSAVSLREQGYASQAYGQKRGYASDKGKKELYSDEGGAVGAGVSRIFVPSEYPSSPMLPQTDDVAHTEAAFDSNADPSQSAKKIQKETGKDYTKHSPAQSDYSQPPGKQGKSGSENPPLNTSNSQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDG5</accession>
    <name>A0A1Y1UDG5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_630156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870227.1">
        <property type="nucleotide sequence ID" value="XM_022016301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDG5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDG5"/>
    <dbReference type="GeneID" id="33558110"/>
    <dbReference type="InParanoid" id="A0A1Y1UDG5"/>
    <dbReference type="OrthoDB" id="187894at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45842" checksum="19439E124258170D" modified="2017-08-30" version="1">MVQSITGMEPSSKLYSRRRLVQENVEEDMELLKHLSELKTDASHYPHAKDIVGNIPVYSGPELLNLIYAGDSSREEIMDELHQCLFTGPGVLIIKEMMEPEMCVRAHEFMKTITPGIETSTHKRTPRFGEKQAKAKPEDYAGYYSNPILAMVCEAWLGLGYQITTQSNAIRAGSDQQEIHRDYHMSHWGDRCRQFPLATHVANQFLTLQCAIAHTPQPLTSGPTRFLPYSNHHPNGYLNIRRQEFKDFVKPRMSQMPLEVGDAAFFNPSTYHQPGVNEQDVHRAMNLFQVNSCMSRCMDTKDTAGMTKAIWPVLKQWHKEIQGSTGSGTERFVNGTKTERHPLELEALINATAEGYEYPINSDKEAPSPRVETDIVRTALREGWDDEKLYKMLDLSAARRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE45</accession>
    <name>A0A1Y1UE45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HECT-like ubiquitin-conjugating enzyme-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870414.1">
        <property type="nucleotide sequence ID" value="XM_022016107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE45"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE45"/>
    <dbReference type="GeneID" id="33557916"/>
    <dbReference type="InParanoid" id="A0A1Y1UE45"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="934" mass="104161" checksum="22DB1E6C9859CEEC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE47</accession>
    <name>A0A1Y1UE47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_628197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870393.1">
        <property type="nucleotide sequence ID" value="XM_022016097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE47"/>
    <dbReference type="FunCoup" id="A0A1Y1UE47">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE47"/>
    <dbReference type="GeneID" id="33557906"/>
    <dbReference type="InParanoid" id="A0A1Y1UE47"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013367749" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="36371" checksum="E6E8003E3315C095" modified="2017-08-30" version="1">MLSRSWSIHQLTLCVFVSLAVAHSDHSFDLNDENDAGMPYAERHMHTEHHIDSFDLESFFKIHDLDLNNVWDRAEIEAVYGLHHHSVIPKQGKHGHADHASEGESKSQALGERAGPIVDEVLRKLDKNGDGKISLQEFMDGGPDGLPSFEGYKDLGHHYDEESEYFLHHEELYHSTPETQTDESYTHPEDIEHFRHHAHIEAEEDARERKFAGLDADADLSQDHPVVDPLDQHDRDGQQKVYKVPTEDMEDGQPMRLHREAKDAGPQRLGADGAGDATQRWERMKNVVKGDRRHGGDDRTRASGPYKSKFRKGLRADEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEB6</accession>
    <name>A0A1Y1UEB6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_491848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870479.1">
        <property type="nucleotide sequence ID" value="XM_022012935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEB6"/>
    <dbReference type="GeneID" id="33554743"/>
    <dbReference type="InParanoid" id="A0A1Y1UEB6"/>
    <dbReference type="OrthoDB" id="2579508at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="337" mass="38073" checksum="440234E90B7ADFF3" modified="2017-08-30" version="1">MPQRPQELVKYLSTPLPQLREQYPPGTGGTGPRSDWSEGTLKTVQVIDDFEQQVKDYLSKQTKEPISPHPNHKFPKFLQEISSVPNVLKAPADLQKCLSTLPLAAVGSVLTALDSDPADFEHDQQTGKAIDGAGYESDGGEHAHATAQPLRDQKTKPWQWRFNKSPMGSGEFHLIKRDSEDVKLVVRTINSSAFSAEDWKEYVVSGSYHYDTRSRASWYWSRSWGATKRLGCDYWVLTDWQRWVFGKFDTPKEHGWVSPILNFDSENPSILQALFYWCRSAIGDTNGYKEELKDVSGSEKLFPVNLGRRSSVKGKDASGTRVKRANESDIEESDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEN4</accession>
    <name>A0A1Y1UEN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_500086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870583.1">
        <property type="nucleotide sequence ID" value="XM_022012950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEN4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEN4"/>
    <dbReference type="GeneID" id="33554758"/>
    <dbReference type="InParanoid" id="A0A1Y1UEN4"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="29726" checksum="6903F4BEFA381EB1" modified="2017-08-30" version="1">MYHLLKGLHAHLTRKDEYSVVIIGLDNVSVLILNSFFQGTSADEPCASGGEDGELKNGPITTVAAELCSLKTMLERIKTMYNATPGMPPDKIGPTVGQNIGKISLPSTTLSFFDLGGQRDIRSIWPRYYDECHAVAFVLDACDQARLNETWEVFDEVLNSPRLLNLPLLLLANKQDAPTCLSVQEIRESFDAWHRARTDDDLDATEEGSPSRDEMSGTADPESQDKKRRAAERMASLDVMGVSALEGDGVREAVNWLYIRVQNARPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEW1</accession>
    <name>A0A1Y1UEW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870206.1">
        <property type="nucleotide sequence ID" value="XM_022016290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEW1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEW1"/>
    <dbReference type="GeneID" id="33558099"/>
    <dbReference type="InParanoid" id="A0A1Y1UEW1"/>
    <dbReference type="OrthoDB" id="2596605at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="659" mass="72444" checksum="6DA49D04FA0A5BBB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF53</accession>
    <name>A0A1Y1UF53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_626871</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870770.1">
        <property type="nucleotide sequence ID" value="XM_022015940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF53"/>
    <dbReference type="FunCoup" id="A0A1Y1UF53">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF53"/>
    <dbReference type="GeneID" id="33557749"/>
    <dbReference type="InParanoid" id="A0A1Y1UF53"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="13"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="538"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX36701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="763" mass="82910" checksum="3C39FFD7A0043190" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFI7</accession>
    <name>A0A1Y1UFI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_627075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870828.1">
        <property type="nucleotide sequence ID" value="XM_022015960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFI7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFI7"/>
    <dbReference type="GeneID" id="33557769"/>
    <dbReference type="InParanoid" id="A0A1Y1UFI7"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="303"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="879" mass="96393" checksum="65FA71E2E337D9E8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFP4</accession>
    <name>A0A1Y1UFP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_651350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870942.1">
        <property type="nucleotide sequence ID" value="XM_022018320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFP4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFP4"/>
    <dbReference type="GeneID" id="33560129"/>
    <dbReference type="InParanoid" id="A0A1Y1UFP4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000425">
        <property type="entry name" value="PLAG1 like zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="709"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="817" mass="88550" checksum="BE39F05BED58EF78" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGE8</accession>
    <name>A0A1Y1UGE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871179.1">
        <property type="nucleotide sequence ID" value="XM_022018198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGE8"/>
    <dbReference type="GeneID" id="33560007"/>
    <dbReference type="InParanoid" id="A0A1Y1UGE8"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012508176" evidence="1">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="399" mass="43312" checksum="26CA0A9A4AEAD401" modified="2017-08-30" version="1">MINWLSLGTIFVWSSSILARNSTSGNSTESNEASSNLDFGPINFAGYTNYVYRDNVTSVQILLTDTSSSYIPSRFITAFPHGNNGALVYFVPLNSTHSNSPSNASGNSTLHTTALGATLNFSSVSSVNQEYNQTGVTGEISVSADLQFGVTLIGGVRTLRDYVESGGTVFHSIFNYTLGPYNDSSVTLIRHWINGSTVQYFQWDTVSNANISVIPNSNATIPPNITITRPDQSSNATIRFTFIYNFTETTPVTPYVPLIGLGREQLFLTEAANGSAPALQSVLTSIQENGSAIADQTAFLAYESKFLAGGWRFLTYFGRDTMLALRLLLPVISTTSAESILGAVLERANETGTLCHEETVGDYASFINIGNNQSYLGNTPYYSYIMLDTDFLLLPVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGT3</accession>
    <name>A0A1Y1UGT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_626923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870785.1">
        <property type="nucleotide sequence ID" value="XM_022015944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGT3"/>
    <dbReference type="GeneID" id="33557753"/>
    <dbReference type="InParanoid" id="A0A1Y1UGT3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="413" mass="43899" checksum="C59B6863E67137CB" modified="2017-08-30" version="1">MPSVMSSARTVDPSTLNEELINATSAIKSKLMAKAPMIHKIDQVTGVSSKVADQINGYFAHMKKPKSSLRTLDRTLSEDGTRAKRTRNQGGGQTDATSAGRTLSEDMGRDRGGGVAATAGEHTTQSSGGGQQTTESLTEGQKRLLAAKKAELNDRWLQAPTVAGSAAGSAIQSRITDLHSKGDKDGLRGFIKSLQGANRNYGIQVAKGLNERDPIDKRSTSNASASQTQGRSSGPATTMTNQASTTNAPLTQTEISRRMKETADQWVKSRRGKPQGTPWTTEEQETFKREVLPSLLTGMSQAVETELRAQAWQKAADGIAKVLQKDDGTRGLETIDTSGKYTMTTYTPAKVTREGLTSLVSDIPPDFLGLSTTGDSSSRNEGSSPASDKPSSMLSRLSSYLPASVQRSVGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH86</accession>
    <name>A0A1Y1UH86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_627560</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870956.1">
        <property type="nucleotide sequence ID" value="XM_022016012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH86"/>
    <dbReference type="FunCoup" id="A0A1Y1UH86">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH86"/>
    <dbReference type="GeneID" id="33557821"/>
    <dbReference type="InParanoid" id="A0A1Y1UH86"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="176"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="270"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="581"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="693"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="764"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="859" mass="95056" checksum="49AEC05EA18CA5AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHC0</accession>
    <name>A0A1Y1UHC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_475716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870943.1">
        <property type="nucleotide sequence ID" value="XM_022012889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHC0"/>
    <dbReference type="FunCoup" id="A0A1Y1UHC0">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHC0"/>
    <dbReference type="GeneID" id="33554697"/>
    <dbReference type="InParanoid" id="A0A1Y1UHC0"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1185" mass="130859" checksum="7EBF0234F10FC092" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHM7</accession>
    <name>A0A1Y1UHM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division control protein 14, SIN component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871548.1">
        <property type="nucleotide sequence ID" value="XM_022015472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHM7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHM7"/>
    <dbReference type="GeneID" id="33557281"/>
    <dbReference type="InParanoid" id="A0A1Y1UHM7"/>
    <dbReference type="OrthoDB" id="2575436at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="994" mass="105327" checksum="325DA164E4B325FE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHU3</accession>
    <name>A0A1Y1UHU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF159-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_624622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871094.1">
        <property type="nucleotide sequence ID" value="XM_022015719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHU3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHU3"/>
    <dbReference type="GeneID" id="33557528"/>
    <dbReference type="InParanoid" id="A0A1Y1UHU3"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46759" checksum="7148E83F5C237E10" modified="2017-08-30" version="1">MCGRYALALSNEELYDGLQNQLPQLFQRGRPRWEREQDYRPNYNVAPRQRQPIIHRDRDSGEAVIETMQWGLIPHWTKHPPSGPMNTINARSESLLDPASGGMWHALKGYKRCIIPAQGYYEWQKKASSKVAHFTRLPLGKQDTNASPPLMFFAGLYDTVEYVSPVESRFQPREGDDREPYPTGNPIPLSTYTILTTVPAKDISWLHDRMPCILKDWEDIERWLDLGKVKGWEDGKGGTGSLLKGTQGLDCFPVPPEVGKIGTNSPTYIQPVSERSDGIKSFFQKQTSSPAKKTGTGKSAEVVKKEDPDQDVKPTSQSNTPDASPMSDDVKPKVESKLDPEIGDDSNAPNEAPPDGVVKKEAQTPGKRKRGKSEDPVDEDAETTQGLARERKGGHQTKVTRKSESEGSKEQPSITAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIE7</accession>
    <name>A0A1Y1UIE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871820.1">
        <property type="nucleotide sequence ID" value="XM_022018136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIE7"/>
    <dbReference type="GeneID" id="33559945"/>
    <dbReference type="InParanoid" id="A0A1Y1UIE7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="172" mass="18552" checksum="C5B1B9A0E2491805" modified="2017-08-30" version="1">MNTNYQPYHPAHAQENKEQFNQGMYTTYQPYHPAFAQESKEQFNQAPPPFAANSPAWNGQAYVNQVPYNANAAPASINAVPHNHGVLPLPNTTVLKSSRLVSPISFGTSITWIVLGGICVIAAIAMMVVNGGAYPGGIGLLAAGLIWLASGTVWLVMIKVHRSRQKKQGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIG0</accession>
    <name>A0A1Y1UIG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_589670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871766.1">
        <property type="nucleotide sequence ID" value="XM_022013782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIG0"/>
    <dbReference type="FunCoup" id="A0A1Y1UIG0">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIG0"/>
    <dbReference type="GeneID" id="33555590"/>
    <dbReference type="InParanoid" id="A0A1Y1UIG0"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="302"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="429"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="504" mass="56014" checksum="E542C62AF8D73821" modified="2017-08-30" version="1">MSPSSVASSSTGSDGGYSDWNDEVELSTQSLFDDSLHPTPDAAIQHDATKHGFDLRQRHLDMYQMMRLVNLIRKEHLSPEDASRIPSSDPRLTDDALLAPVIPDDPLLQYSFDDAWSDGPSEASISVQLSHARAEAAALRSVIDTEEPEAVPRRVDNDSHYFDSYSENEIHEIMLKDTVRTTTYGKFILSNPEIFNGATVLDVGCGTGILSMFAARAGAKKVYAVDASALVGKTREIIAINGFSDVIEVINRKMEELDLPEPVDVIISEWMGYMLLYESMLDSVLDARDRFLKPTGLMAPSQAKVLLSGITGDKVHGERVGFWKNIYGFDMSAMSKVHQAEGLIENVPHSEVVTDDVVLRDINIHSATPRSLDFNTAFDLTATRSCTMRAFLTHFDVFFELHRDALHPGKADATKSSDNVTEPPPITPGPVSFTTGTRGDPTHWQQVAFLLKEPIELAKDAHISGQFYCRKSSSNTRELDVEIHYTLDKTAERRTWTVQTYTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIG4</accession>
    <name>A0A1Y1UIG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_623504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871827.1">
        <property type="nucleotide sequence ID" value="XM_022015590.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIG4"/>
    <dbReference type="GeneID" id="33557399"/>
    <dbReference type="InParanoid" id="A0A1Y1UIG4"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="874"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1242"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1272"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="592"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1335" mass="146042" checksum="A70B4BE033C1E10E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIG8</accession>
    <name>A0A1Y1UIG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_625542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871322.1">
        <property type="nucleotide sequence ID" value="XM_022015811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIG8"/>
    <dbReference type="GeneID" id="33557620"/>
    <dbReference type="InParanoid" id="A0A1Y1UIG8"/>
    <dbReference type="OrthoDB" id="2570597at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="208" mass="22874" checksum="3503AD71E07EC1F4" modified="2017-08-30" version="1">MSVTRGTSILGSPFLNLTVIDKALLTCTDLSERIKLLSAKIHVLSRDANIGINRSSPSEPGTMKGYGVWEETRLMRTRLELARALMTMPGRMAEAESEITTVLSDCKRCSKMLPHSRTRTRKVAGDLATVHPDGAVVDDYAQPAKSEDELPTGNPALGDLNHIQRVRLEALRLLVDVEEALGREGRTKRWRDLIGQLEKEAQQSGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UII2</accession>
    <name>A0A1Y1UII2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_404618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871847.1">
        <property type="nucleotide sequence ID" value="XM_022012694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UII2"/>
    <dbReference type="GeneID" id="33554502"/>
    <dbReference type="InParanoid" id="A0A1Y1UII2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="161" mass="18563" checksum="BFB10DE07BDCE38A" modified="2017-08-30" version="1">MQQQLLLKNRWVRNQIFGPLACNWREKGIGFNPKRRQSRHSQTSATFLYRRYSQRCPLYSNADPPLSPRPFSIPGGQSQGPLQSEFESLERFFPLQPSSHRESQLFEERANTGSNEIALLTLYLSLLLVLFLLVSLSLPLSLLSDTFHPITFSSPDDHRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UII5</accession>
    <name>A0A1Y1UII5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871828.1">
        <property type="nucleotide sequence ID" value="XM_022015591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UII5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UII5"/>
    <dbReference type="GeneID" id="33557400"/>
    <dbReference type="InParanoid" id="A0A1Y1UII5"/>
    <dbReference type="OrthoDB" id="2564482at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299385" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="29818" checksum="FD30536BAC6C5EB4" modified="2017-08-30" version="1">MRFSLLPLLTLLLFPAQLAAFSVRGGHLSDKGLSSIDQPFTPTERGCTTNAECLQRGLPILKPSPRRTARRSGMSSQVINTPVLVYPAGQGGPNPTRRKRYLGEAGEKRDTLPAGAFGWLEDTVQNDGQYDFSTPDVSGAVTFSIDITTSQPQSILRSDFTRTPYLCAGLTGTGLGSTYDVASITQCASPGTVGEAPSTNVNCNGDSTAEAFVWVLNTSTGQLSIQWYNSGASDPIDAYPIGIEESGGIIYIAGLIAGSLSDYNADTGGSFDAYEFYIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIQ6</accession>
    <name>A0A1Y1UIQ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_623864</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871917.1">
        <property type="nucleotide sequence ID" value="XM_022015635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIQ6"/>
    <dbReference type="FunCoup" id="A0A1Y1UIQ6">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIQ6"/>
    <dbReference type="GeneID" id="33557444"/>
    <dbReference type="InParanoid" id="A0A1Y1UIQ6"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="13">
        <location>
            <begin position="62"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="351" mass="38531" checksum="4F9E15E0AF24A767" modified="2017-08-30" version="1">MNIVVLLIACFALGLITIHFLLMLFTPHPIPITEEEKTYTTLPDSAPQHLPALSDPASIALSIVVPAYNEELRLGTMLDEVVEYLTHHKRHHPRQPENSGTPKFKDGAEIIVVDDGSSDSTTKVAERLAASWAKYIDGKGIDIRVVTLRTNRGKGGAVQHGVVHARGRLILFADADGATRFADLDNLLEAMEKIKDKDGHGIVIGSRAHLVKSEAVVKRSKVRNALMHGFHLFLRTIGVGGIRDTQCGFKLFTRPTAQLLFPTLHLHRWAFDVELLLLASLVVPPIPVVEIPVAWEEVDGSKIRLGWDSIGMARDLLVLRGNLLFGKWIVPGRAKVESGKVNGHAEVTNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIV9</accession>
    <name>A0A1Y1UIV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_413754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871990.1">
        <property type="nucleotide sequence ID" value="XM_022012720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIV9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIV9"/>
    <dbReference type="GeneID" id="33554528"/>
    <dbReference type="InParanoid" id="A0A1Y1UIV9"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="602" mass="65767" checksum="F175E8E29B259A3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJH7</accession>
    <name>A0A1Y1UJH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_619992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872133.1">
        <property type="nucleotide sequence ID" value="XM_022015240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJH7"/>
    <dbReference type="GeneID" id="33557048"/>
    <dbReference type="InParanoid" id="A0A1Y1UJH7"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="70"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="563" mass="62442" checksum="B4E370AB61DB23A9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJW6</accession>
    <name>A0A1Y1UJW6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavo protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872273.1">
        <property type="nucleotide sequence ID" value="XM_022015293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJW6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJW6"/>
    <dbReference type="GeneID" id="33557101"/>
    <dbReference type="InParanoid" id="A0A1Y1UJW6"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="235" mass="26307" checksum="9D9E12765E570274" modified="2017-08-30" version="1">MASRLPLHIGILLGSARSPNNTSGFYKLVRQHLERLAPGSKISAYDPFTAPLPLGPYVMSAMASTLKPERREDGFANFGYPDPRVQEWSQIVQDLDALIIITPQYNWSFPSTIKEAVDHLYYEWANLPFATVNFGGMGGGDKCASALDQVIRGVHGNPVSTRKITIKLDPKYFNHDHILSGDEDFLKEHSELLDQEMRKVISAAKERQHVKKEFIMNAPAWVAEEKAKARAASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJZ5</accession>
    <name>A0A1Y1UJZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_607843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872231.1">
        <property type="nucleotide sequence ID" value="XM_022014086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJZ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJZ5"/>
    <dbReference type="GeneID" id="33555894"/>
    <dbReference type="InParanoid" id="A0A1Y1UJZ5"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="515" mass="54278" checksum="D7A1F7C58C83A6B3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK79</accession>
    <name>A0A1Y1UK79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872380.1">
        <property type="nucleotide sequence ID" value="XM_022015339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK79"/>
    <dbReference type="FunCoup" id="A0A1Y1UK79">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK79"/>
    <dbReference type="GeneID" id="33557148"/>
    <dbReference type="InParanoid" id="A0A1Y1UK79"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="84"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="451" mass="49421" checksum="FFF5EFAF6F0DE393" modified="2017-08-30" version="1">MVSTRPSPAPAKGRMAYPSASNYTPGDVDNSPSFLGSTSPPTDADRERAQGLKLWWKAFRDQGPAEGPRVFGVPLSESIKYASVQISTAAEDGSLYVWGVIPVVVAKCGLYLKENGTEVEGAFRISGSTKRMRDLQAVFDSGPKYGKNINWKVLPYTTHDVATIFRRFLTQMPEPIIPFEFYDQFREGLDAEAVQETIDRYKELIRALPPVNQYLLLYVLDLLHVFANNSEQNLMTAPNLALIFQPGVLSHPVHVMRPRDHVLSQQVLEFLIENQDHFLIGMQLPKRDTKSPSILSSRSSTPPPSVRMVKADPDFMLPSDSDDEAPAGGYYVVESSGRKPVSATQPEYSAPKIEPSLIPSKPAPVAYTSNDIMDPSDSDDDAPPGGYEVRIGDPARARAAFLTRTAVAGKSRAAAPSPTPSSIARRRTLPAGHSSGWKARRKDQAVKEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK92</accession>
    <name>A0A1Y1UK92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase expression-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_680827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871944.1">
        <property type="nucleotide sequence ID" value="XM_022019097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK92"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK92"/>
    <dbReference type="GeneID" id="33560906"/>
    <dbReference type="InParanoid" id="A0A1Y1UK92"/>
    <dbReference type="OrthoDB" id="2554293at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="116681" checksum="9810AB927968ED83" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK93</accession>
    <name>A0A1Y1UK93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872324.1">
        <property type="nucleotide sequence ID" value="XM_022015315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK93"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK93"/>
    <dbReference type="GeneID" id="33557123"/>
    <dbReference type="InParanoid" id="A0A1Y1UK93"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="211"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="450" mass="48778" checksum="13687956B95660E6" modified="2017-08-30" version="1">MSDAGPSQQQSGGGHQGRGGSSSGQKNKSWKYKVAAQAEGQGRGGRGQGRGGRGGRGRGGGGGRGGSHGAHGDAGGGSRSDAAPGPKWESSDRPNHLGRYRDDPVSEIMMAPGICVTTVRDKERSAERELVEYLERIADELYPDAHEVIVKAESRIGEEEDFEEMLKQELADMSVEKKSSRFRLCKHETPCVIYVEVLPPLDPARLVVHMMEQIEKNARCPFRYVQRVVPVLGTCGATLPQLSAMCPEVLKEGFQSDTAGPVTFGILYNSRNSQRLDRMDVIKSIAEHVSTLDPSHTVDLKNPDRTILVETNKNRLGLSVVKDYERFKKYNAYALAGSRAQAELASSEAAPINAEATKSGPSRSQQKHAHRDIRAAKMAAASSTPSNKRKLEDMQRPGDGVEHEAFLDTMAGEGASGGTVGQSRGDEWQEIIEGGRVVKMRKEEPETDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKF7</accession>
    <name>A0A1Y1UKF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_621278</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872462.1">
        <property type="nucleotide sequence ID" value="XM_022015370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKF7"/>
    <dbReference type="FunCoup" id="A0A1Y1UKF7">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKF7"/>
    <dbReference type="GeneID" id="33557179"/>
    <dbReference type="InParanoid" id="A0A1Y1UKF7"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01702">
        <property type="entry name" value="PolY_Pol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="39"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="657" mass="72902" checksum="96E69C41AE0ED03F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKG3</accession>
    <name>A0A1Y1UKG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_563689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871943.1">
        <property type="nucleotide sequence ID" value="XM_022013026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKG3"/>
    <dbReference type="FunCoup" id="A0A1Y1UKG3">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKG3"/>
    <dbReference type="GeneID" id="33554834"/>
    <dbReference type="InParanoid" id="A0A1Y1UKG3"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="232" mass="25781" checksum="10FDF14F15FE318C" modified="2017-08-30" version="1" fragment="single">ISILDSSFNPPHNAHLALASEPFPPRSVSEDLPSAYTHRLLVFSTTNVDKKPASGDPTLEQRVEMIKMLASNVGGPESKSPAAVGLINEPTFVGKSRIIHSYLLTRGFKERPHLTFIVGTDTLTRFFDPRYYGAVPGGMNQALDRFFVEEGSSLVCGRRKGEEEVEAALLKREEIRQRVDNGQVRFFADGSEDWAGVSSTDVRKAVQRGDWDGVDRLVTPEIAAYIKDQRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKH9</accession>
    <name>A0A1Y1UKH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lanthionine synthetase C-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_621140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872431.1">
        <property type="nucleotide sequence ID" value="XM_022015361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKH9"/>
    <dbReference type="GeneID" id="33557170"/>
    <dbReference type="InParanoid" id="A0A1Y1UKH9"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45338" checksum="8899B4C14CF660FA" modified="2017-08-30" version="1">MSSATPERPRCLPNDGTFRSFDADSEIPRHASILVTRFPPAISTFNKAEDCLGFYSGPTSIAYSFFLLKDDLPPSIEGKSPIEWAKAYLETAKELLETSFDPKHQLRNVGTSFCGITCETLCRALTEAVVYDDAALLEPLFQYAPEINETTPSTLDEWVLGRAGYLYNLRAAAHYFPSISSKTQPIIKKVVESMLEHAPDSKEPWKFAGDYYLGTAHGWIGNLTAILLSDPSPERAKQLRPYFVDILRQQLPNGNWRGFADIHVVNPEKPKENREVWIQFGHGGPGFVCSFLAIRHLYEGDEEFLRMVDEAVNRAQDCIWQRAYLTKESSILHGAAGNSLALLDQKQKETLLAVSTQEEVDKANEAGTHEPSNSSSGLHRGLAGRIWAMVQYKKGQSGVFPTYNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKQ6</accession>
    <name>A0A1Y1UKQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_373168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872560.1">
        <property type="nucleotide sequence ID" value="XM_022012615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKQ6"/>
    <dbReference type="GeneID" id="33554423"/>
    <dbReference type="InParanoid" id="A0A1Y1UKQ6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="231" mass="25378" checksum="5196D3161F155C95" modified="2017-08-30" version="1">MAFTPFSNGNSNFFLSVSNVITISSREQCRSGNWGVFRSARERASWRVDGEAYMVKAGGKPGPKAIDYEAFQRSQRSACLSPITAGMRFESIPNSHELAGHFKPTSRRQEEVEKSPVCHDVAFSPKRIGRCGAGASRFDTCYIESSSSCSRGFPHRFLSRSHHLSLPTLFSIAGNPPASYQGDTHRIFGIDSSQILNPKIYLGTLLNQITGRNACSYYSPIPLSTLPASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKX4</accession>
    <name>A0A1Y1UKX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Betaine lipid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_641879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871762.1">
        <property type="nucleotide sequence ID" value="XM_022017454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKX4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKX4"/>
    <dbReference type="GeneID" id="33559263"/>
    <dbReference type="InParanoid" id="A0A1Y1UKX4"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="89719" checksum="50F739A602F3455A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKX6</accession>
    <name>A0A1Y1UKX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_622010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872630.1">
        <property type="nucleotide sequence ID" value="XM_022015431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKX6"/>
    <dbReference type="FunCoup" id="A0A1Y1UKX6">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKX6"/>
    <dbReference type="GeneID" id="33557240"/>
    <dbReference type="InParanoid" id="A0A1Y1UKX6"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="228" mass="25146" checksum="1F42E3386AC8F2BD" modified="2017-08-30" version="1">MANPRQRNKARSSKSTKPSLAAKRRMHHKLRKPPTLSGPEVLQSGWDKHKTVFQNYKALGLLPSLPLPTASGSRSYRTRLTLPPGAIGSASGPVDNVNGLGGAVFSGFGQIIRDEEGNVVDIIIPEEQEQDQTPPEQEADDAEEGEERNRVEAQTDVVRSLEQLAASSVPVKRHSSTSERTWLQDLVRAHGSNYEAMARDHKLNVWQKTQGEIKRMVNKAGGVDKLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL86</accession>
    <name>A0A1Y1UL86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_607803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872168.1">
        <property type="nucleotide sequence ID" value="XM_022014084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL86"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL86"/>
    <dbReference type="GeneID" id="33555892"/>
    <dbReference type="InParanoid" id="A0A1Y1UL86"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000728">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="909"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="953"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="955"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="992" mass="106229" checksum="5AC8E86905C74703" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULF4</accession>
    <name>A0A1Y1ULF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_617672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872743.1">
        <property type="nucleotide sequence ID" value="XM_022014944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULF4"/>
    <dbReference type="GeneID" id="33556752"/>
    <dbReference type="InParanoid" id="A0A1Y1ULF4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="65" mass="7215" checksum="5AF8BDCFD79FDF64" modified="2017-08-30" version="1">MLRASCLPTSASCFCFLLLLLLPLLFLVPPGFCFSFCSVFFCLPAPLLSYFCFCFLLLLPLLLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULQ4</accession>
    <name>A0A1Y1ULQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_618049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872834.1">
        <property type="nucleotide sequence ID" value="XM_022014984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULQ4"/>
    <dbReference type="GeneID" id="33556792"/>
    <dbReference type="InParanoid" id="A0A1Y1ULQ4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="59" mass="6760" checksum="DCCE52D3FFDF45BC" modified="2017-08-30" version="1">MLVLASSPRTPNRVTAIIHSFHHPGRLPVALLNTFQSMSFLLASTTHFWHYWGLTWLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULX8</accession>
    <name>A0A1Y1ULX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_618341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872914.1">
        <property type="nucleotide sequence ID" value="XM_022015016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULX8"/>
    <dbReference type="FunCoup" id="A0A1Y1ULX8">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULX8"/>
    <dbReference type="GeneID" id="33556824"/>
    <dbReference type="InParanoid" id="A0A1Y1ULX8"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="333" mass="39139" checksum="D652B872AD9D278E" modified="2017-08-30" version="1">MSSGRSVSRIYADVNEKQGRSWWDYDNLVVSWGNQDHYEIVRKVGRGKYSEVFESVHIPTSQKCIVKVLKPVKKKKIKREIKILQNLAGGPNVIALLDVVRDAQSKTPSIISEYVNNTDFKTLYPKFTDFDVRFYMLELLKALDFCHSKGIMHRDVKPHNVMIDHEKRKLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNSDQLVKIAKVLGTDELNLYLERYDIELDPQFDEILGRYPRKPWSRFITSDNQRYISNEAVDFLDKLLRYDHQERLTAKESQDHAYFAPVKEAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULY8</accession>
    <name>A0A1Y1ULY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_679564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872924.1">
        <property type="nucleotide sequence ID" value="XM_022019045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULY8"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULY8"/>
    <dbReference type="GeneID" id="33560854"/>
    <dbReference type="InParanoid" id="A0A1Y1ULY8"/>
    <dbReference type="OrthoDB" id="2503643at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="85" mass="8937" checksum="1020A0F764E56B8A" modified="2017-08-30" version="1">MSKVDSYASVKSLHASLPPFSPLISVDMLPYIALICISAFFVLTFTFSTLPKSRNPLPELGTGLLASGLAGIGIVALFCTVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM33</accession>
    <name>A0A1Y1UM33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_618550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872974.1">
        <property type="nucleotide sequence ID" value="XM_022015046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM33"/>
    <dbReference type="FunCoup" id="A0A1Y1UM33">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM33"/>
    <dbReference type="GeneID" id="33556854"/>
    <dbReference type="InParanoid" id="A0A1Y1UM33"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="270" mass="29556" checksum="91558AD7BD59D11D" modified="2017-08-30" version="1">MGVKAAQDLYLDPSIRNWVLVPITLIMLLVGILRHYVTMLLTSPPKPAAVDVVREQRAIGRAQLLRMTAPFSPLSPAAYRSISAAHSTVLTSGQYLKIKPKPKEGEIPNPFEGGGMENAMEGMKKQAVMMVPNMVIMQYISIFFSGFVLIKLPFPLTAGFKSLMSKDIMTPDLDVRWVSALSWYFLNLFGLNGVFRLILGDAGPQVESRDANALAQLSGAGAVSLSGPGAPDMEKLFKAETENLALAEGLYRWSADGVEDRVLEIWGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMR6</accession>
    <name>A0A1Y1UMR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872670.1">
        <property type="nucleotide sequence ID" value="XM_022014919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMR6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMR6"/>
    <dbReference type="GeneID" id="33556727"/>
    <dbReference type="InParanoid" id="A0A1Y1UMR6"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="70"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="521" mass="56167" checksum="F5AA91E8FAE76A71" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMT7</accession>
    <name>A0A1Y1UMT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_619269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873192.1">
        <property type="nucleotide sequence ID" value="XM_022015154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMT7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMT7"/>
    <dbReference type="GeneID" id="33556962"/>
    <dbReference type="InParanoid" id="A0A1Y1UMT7"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="109"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="35602" checksum="354D082B365379EC" modified="2017-08-30" version="1">MRGLQSDSNGEMSRMSPATVWKQVTGAGRNVVHRYNRLSVKGKTALVSVSLINVGLLIAVIIITPTRIGNWFNHLAESLRAMGVGGMFICALFVVIASHPPLFGFMGSMTLIGFTYGVWPGFLVASLAALSGAAIAFISVRTFFLGWIRKRSNDKWEAFGHVMRNKGLPLVVMIRYCPLPWAMGNGLFASIESVKLWQYMIANLAILPKLLIPVFIGSRLTSLTHDRPSHDPLQFWLNIGSILLSCSISILTGIWIYRLTLEQMRKLNDGGDEGELAADALERGALLGDYTDDEEAADEPLTLGHSMRPSDSMLRRTSSSSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMU2</accession>
    <name>A0A1Y1UMU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_324643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873175.1">
        <property type="nucleotide sequence ID" value="XM_022012486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMU2"/>
    <dbReference type="FunCoup" id="A0A1Y1UMU2">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMU2"/>
    <dbReference type="GeneID" id="33554294"/>
    <dbReference type="InParanoid" id="A0A1Y1UMU2"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="391" mass="44529" checksum="94CE82DEB5F53559" modified="2017-08-30" version="1">MNQAYPEANVHTFLPLPPRSLTAPPPPYHLPTLIGTYSHLSDRTIVHDDTSMPYYRKAPVGCDLNYGFERRIERDEDLEEHLDGLCESLMEIEQRNGRPALRQGSFITWRGMITRIMTAPFEERDGWEMTAIPLGGSIYVELHDPPDVRQRRRKEQSSWAWQSYMGYSFESFSTFPPAGEAQSPDWPQGWSGDVNQNIQWCNIVRSAIGDIPLCLGGEVDCVNVPPGSPHPGLLGCMELKTNKVIENQKQDIIFNKKLLKHWAQSFLLGVPTVEVGFRDDDGILRSQTSFETVKIPRLVAAIPQPPWSPAPCFHFLHAVLNLVLTHVLPTDPTPKRPLQEHEPLPDAMVWRFSFVPRRGCELYKVGTVKTAHGRWGGVLKEDFVRWRMTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNG8</accession>
    <name>A0A1Y1UNG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="8">HIU hydrolase</shortName>
            <shortName evidence="8">HIUHase</shortName>
            <ecNumber evidence="8">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_649101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872869.1">
        <property type="nucleotide sequence ID" value="XM_022017937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNG8"/>
    <dbReference type="FunCoup" id="A0A1Y1UNG8">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNG8"/>
    <dbReference type="GeneID" id="33559746"/>
    <dbReference type="InParanoid" id="A0A1Y1UNG8"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600895-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="125" mass="13505" checksum="BD81F84C62C6E452" modified="2017-08-30" version="1">MSKSPITCHVLDSSIGKPAQGVACTLECLSLDPLDDSVTSAALPSTLASGVTDADGRCSSLLEPTFQVAKGVYKMVFQTGAYFESRGVETFFPVVEITFRFSNPDQHYHVPLLLSPFSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNQ4</accession>
    <name>A0A1Y1UNQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872959.1">
        <property type="nucleotide sequence ID" value="XM_022015036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNQ4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNQ4"/>
    <dbReference type="GeneID" id="33556844"/>
    <dbReference type="InParanoid" id="A0A1Y1UNQ4"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="342" mass="37586" checksum="30F4E725D1DCB83E" modified="2017-08-30" version="1">MIVSMFGPESIWSEPLQLDQNVTVTGLSPLYPEVHCDSNGTICQFVTGEAEINAACSMTALLLSHKFDFRKTYFMIAGIAGINPFEGTLGSVGLAQFAVQVALAYELDARQIPSNWTTGYWLQGTNQPGDPPNPDDIYGTEVFELNTNLRQKAFEFTKGVELNDTASAAAYRARFNYAPANQPPSVFFGDVATSDVYFAGSDLAEAFGNITLQWTNNTGHYALTAQEDNASFEAMVRADRAGLMDFSRVILMRTASDFDRAPPNLTELYAFEYNQGGFPPSIANILIAGQPIVEGIIANWDSEFEQGIAPQANWSYNADDLHTLAQKKMAATRRRMTTVPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNR3</accession>
    <name>A0A1Y1UNR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_640889</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="13">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="13"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873466.1">
        <property type="nucleotide sequence ID" value="XM_022017382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNR3"/>
    <dbReference type="FunCoup" id="A0A1Y1UNR3">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNR3"/>
    <dbReference type="GeneID" id="33559191"/>
    <dbReference type="InParanoid" id="A0A1Y1UNR3"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="225"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX39681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="480" mass="52953" checksum="BD8893193B37D01D" modified="2017-08-30" version="1">MAPTDQFSSLSLSPATSSAIERMGFQNMTTVQARTIPPLLAGKDVLGAAKTGSGKTMAFLVPAVELLNTLRFKPLNGTGVVIISPTRELALQIFGVAKELMQGHSQTFAVIMGGANRKAEAEKLAKGVNLLVATPGRLLDHLQNTKGFRFSNLKNLVIDEADTLLSIGFEEELQAILKILPKERQTSLFSATLSTSVNSLAKLSLRPNPLYINVDEDKVEAVPETLQQGYIVVPEDLRFMLLYTYLKRNSKKKIIVFFSSCNAVNYYSELLNYLDVPVLSIHGKMKQASRSNTFFEFSNAQHGTLLATDVAARGLDIPSVHTSISFDCPADPKDYIHRVGRTARAGKIGKSLLFLLPSELGFLRFLKIAKVPLNEYQCPPLKIANVQTQLENLISKNHYLNQSAREAFRSYLQAYASHSLKSVFDINKLDLAKVAKSFGFASPPKVNISAKRPAADDVDSDDEAAIRQKKRHNSKKRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNV4</accession>
    <name>A0A1Y1UNV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_586717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873484.1">
        <property type="nucleotide sequence ID" value="XM_022013747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNV4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNV4"/>
    <dbReference type="GeneID" id="33555555"/>
    <dbReference type="InParanoid" id="A0A1Y1UNV4"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="115"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="658"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="85828" checksum="50C68B71C50286C3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNW2</accession>
    <name>A0A1Y1UNW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_618896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873090.1">
        <property type="nucleotide sequence ID" value="XM_022015094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNW2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNW2"/>
    <dbReference type="GeneID" id="33556902"/>
    <dbReference type="InParanoid" id="A0A1Y1UNW2"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="606" mass="65899" checksum="D2C7C6EDE7236D8C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNW9</accession>
    <name>A0A1Y1UNW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_618700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873029.1">
        <property type="nucleotide sequence ID" value="XM_022015069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNW9"/>
    <dbReference type="FunCoup" id="A0A1Y1UNW9">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNW9"/>
    <dbReference type="GeneID" id="33556877"/>
    <dbReference type="InParanoid" id="A0A1Y1UNW9"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="61"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="438" mass="50203" checksum="58C452B51E61E974" modified="2017-08-30" version="1">MQYQQQQPQPVEDGLGTSGGTSGVNGHSGTQPVNPINRKKLASWVGFSNLPNQVHRRSMRRGFNFTAMVVGESGLGKSTLINTLFETKLYEPKQIPAPGVDRGRTVQIESISADIEENGVRLKLTVVDTPGFGDFVNNDESWRPIVDNIEARFDAYLEQENRVNRLKLVDNRVHACIYFIQPTGHSLKPIDIEFMRRLHTKVNLIPVIAKADTLTEEEVVLSKRRVLADIAHHGIRIFQPPQYENEDEETIQENEEIISKVPFAVVGSDNIVRSPNGREVRGRAYPWGVIEVDNEEHCDFVKLRQMLVRTHMEELREHTNDILYENYRTDKLKAMGVSQDESVFKETNPAAKQAEERALHEAKLAKMEAEMKMVFQQKVQEKEQKLKQSEEELYARHREMKEALEKQRLDLEDKKRRVESGRPLTPEKGTKKRFGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNZ5</accession>
    <name>A0A1Y1UNZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873546.1">
        <property type="nucleotide sequence ID" value="XM_022017832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNZ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNZ5"/>
    <dbReference type="GeneID" id="33559641"/>
    <dbReference type="InParanoid" id="A0A1Y1UNZ5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
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        </location>
    </feature>
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        <location>
            <begin position="943"/>
            <end position="983"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
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            <end position="136"/>
        </location>
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        </location>
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            <end position="228"/>
        </location>
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            <end position="555"/>
        </location>
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            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
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        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
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        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="995" mass="106074" checksum="8B1C81192CB5EE40" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPA2</accession>
    <name>A0A1Y1UPA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_615273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873646.1">
        <property type="nucleotide sequence ID" value="XM_022014705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPA2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPA2"/>
    <dbReference type="GeneID" id="33556513"/>
    <dbReference type="InParanoid" id="A0A1Y1UPA2"/>
    <dbReference type="OrthoDB" id="2586638at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22684" checksum="5DDC0DC916CBA0E8" modified="2017-08-30" version="1">MSDEGIELQPVGSSTLKPRIPPRHPDTAPGGLGAAYRAAEDKAKAAVHLQEGNLDNVSVWGLVAAGWFTILALPLLLFPRILVFFSQTPAPGPGIANLERDHYDTLTPLESFLALTLALGLVSLALLVFLTLVPSYTPPSPSRWPLLAIIVGLTSTMSVIAWNAPIGGLGKVTGIGNTLVAIWGWWVVVFGQGRSNMANVGKKIHPKRWEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPN3</accession>
    <name>A0A1Y1UPN3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_618498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872958.1">
        <property type="nucleotide sequence ID" value="XM_022015035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPN3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPN3"/>
    <dbReference type="GeneID" id="33556843"/>
    <dbReference type="InParanoid" id="A0A1Y1UPN3"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="720" mass="76693" checksum="A65CE38F6DA1A7AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ43</accession>
    <name>A0A1Y1UQ43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_614216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022014574.1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="70688" checksum="93075807EA5C86A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQE5</accession>
    <name>A0A1Y1UQE5_9TREE</name>
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        <submittedName>
            <fullName evidence="4">YL1 nuclear protein-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">BD324DRAFT_617105</name>
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    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022014881.1"/>
    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UQE5"/>
    <dbReference type="GeneID" id="33556689"/>
    <dbReference type="InParanoid" id="A0A1Y1UQE5"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="675" mass="74502" checksum="FAE1EEC0F588340C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URW3</accession>
    <name>A0A1Y1URW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_612077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874457.1">
        <property type="nucleotide sequence ID" value="XM_022014346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URW3"/>
    <dbReference type="STRING" id="4999.A0A1Y1URW3"/>
    <dbReference type="GeneID" id="33556154"/>
    <dbReference type="InParanoid" id="A0A1Y1URW3"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040909">
        <property type="entry name" value="CHFR_Znf-CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17979">
        <property type="entry name" value="zf-CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="457"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="586" mass="64597" checksum="BE0A03E787949CFE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URX3</accession>
    <name>A0A1Y1URX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_611864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874398.1">
        <property type="nucleotide sequence ID" value="XM_022014321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URX3"/>
    <dbReference type="GeneID" id="33556129"/>
    <dbReference type="InParanoid" id="A0A1Y1URX3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="90" mass="10163" checksum="415D47C3ED6F7A90" modified="2017-08-30" version="1">MPLHTTRIKRTMPSRTSHKGKYSLISYHRYPLHLFHSFLLLLTTLLILLEGSSGPGSGYWWIDLKYTDGGSWLLGGLGACEKGIRSVCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USA9</accession>
    <name>A0A1Y1USA9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_616143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873860.1">
        <property type="nucleotide sequence ID" value="XM_022014797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USA9"/>
    <dbReference type="FunCoup" id="A0A1Y1USA9">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USA9"/>
    <dbReference type="GeneID" id="33556605"/>
    <dbReference type="InParanoid" id="A0A1Y1USA9"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="207" mass="22131" checksum="E198D86C36146308" modified="2017-08-30" version="1">MASAMRTVLRRGYATAKDVKPPIQLNSLTGTYATSAYVAALKKSSKDLEQLAKDVESFDKKMKSDSKIDAFVRNPTLSSTERSLVLKELVGSSSSPMLLNLLTVLSENGRLASAPKVFDDFGSLMAAYRGELEVIVTSAEPLDSSAMSRLDKALKATEIAKGKKIKIQNKVNPAVLGGLVVDFGDKTIDLSASSKVNRFNAALAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USH9</accession>
    <name>A0A1Y1USH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_616559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873930.1">
        <property type="nucleotide sequence ID" value="XM_022014837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USH9"/>
    <dbReference type="STRING" id="4999.A0A1Y1USH9"/>
    <dbReference type="GeneID" id="33556645"/>
    <dbReference type="InParanoid" id="A0A1Y1USH9"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="265" mass="28810" checksum="9584F5983F2ED652" modified="2017-08-30" version="1">MPPLPDLSTATVLITGGTSGVGRALAERFAKSGSRVFVTSRRPPPDPSTVKLDNGGTITTIQSDVSKSSERESLYEYVREHLPRLNILINNAGIARPVPMSQDGPGISWTERQLEIDTVVSGPIHLTSLLVPLMLENETEGQVINVTSGTAFFPNPSAPLYAACKAAARSYTITLRFALRETKIGVTEIIPPMIETGLDGSKGGIQLSDFMDGIWPKVLQGDEEVVYGITDSDLVKEARDIQDKCFGQMKQYLMDIDHYGKTEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI2</accession>
    <name>A0A1Y1USI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_10556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874276.1">
        <property type="nucleotide sequence ID" value="XM_022011920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USI2"/>
    <dbReference type="GeneID" id="33553728"/>
    <dbReference type="InParanoid" id="A0A1Y1USI2"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="250" mass="27401" checksum="3F1476C87EFEDE92" modified="2017-08-30" version="1">MLDAHDLEREAYRPFFFRIAHIVNQGQNRIELCGSLVYGGGLTPTIGLVRQIKNIIESSRIMVMVRPRTGSFIYTPEEINTMIEDIKAFKAEGVRGVVFGCLTEDGAIDEKVTKQLVAAARPLDVTFHRAFDISTGLDTLQRIGGITRLLTSGHGKTVMDGAVELSGLISHSSSVNGPIICPASGINNETVLRLHKAVPGLKEVHLTGSGIIPYPKDSRSIMAQDLGFGAGEWHLDPVKIERVWDIVKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USQ5</accession>
    <name>A0A1Y1USQ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874720.1">
        <property type="nucleotide sequence ID" value="XM_022017745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USQ5"/>
    <dbReference type="GeneID" id="33559554"/>
    <dbReference type="InParanoid" id="A0A1Y1USQ5"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="106" mass="12303" checksum="46D5E45D37024F8F" modified="2017-08-30" version="1">MPRFLCYCPDYPDALELRLSVRARHLEDSDRDKEAGRQTDGSAFLAIPGSEAASRTVPEGQPNLTGSFMIYNLETIDQVWDRIRKDAYWENNVWDREKLTVWPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USS7</accession>
    <name>A0A1Y1USS7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_269851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874040.1">
        <property type="nucleotide sequence ID" value="XM_022012337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USS7"/>
    <dbReference type="STRING" id="4999.A0A1Y1USS7"/>
    <dbReference type="GeneID" id="33554145"/>
    <dbReference type="InParanoid" id="A0A1Y1USS7"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="263" mass="27965" checksum="2D7EE9368648536E" modified="2017-08-30" version="1">MDSQSLFSVRGKVVLVTGGGRGVGEMIASGFVANGAKVYISSRDAKACEETAKRLSAVGPGQCLAIAADLSKYEECVRLAKELERREEALHILVNNSGAAWGDELDTYPDAAFTKLLTLNVQRVFTLTQKLLPLLRHGSGQDGPSRVINIGSVNGINVPVFETYAYSASKAALHQLSRHLAVKLGPVITVNALALGPFRSRMMQSTLDSIETELSESLPMKRIGRAEDVAAACLWLSSKGGEWVTGTVIPIEGGGLVSPDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT95</accession>
    <name>A0A1Y1UT95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874928.1">
        <property type="nucleotide sequence ID" value="XM_022017789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT95"/>
    <dbReference type="GeneID" id="33559598"/>
    <dbReference type="InParanoid" id="A0A1Y1UT95"/>
    <dbReference type="OrthoDB" id="2565062at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="217" mass="23286" checksum="7946605590BE714E" modified="2017-08-30" version="1">MGWMLMHFEQYTNGLYSLSHLVRSSIHIRSFKASFDPSAQSQSSRHLSAISYSQPSAQGNNSSSVKDDTTYLFLENKGDSSESEPQPRDKYKILAVKPSAVPLALLQNLMNPFVMGLSKSAKSAASATATQSSLVPTPLPGQSLLITSFAFPPLSPPGPQMVVTVHSLPAPTASSIFLEIEHGTSKCSNGTHQKAGGKIGRMAPREIVESPISWLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTJ5</accession>
    <name>A0A1Y1UTJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_54616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874961.1">
        <property type="nucleotide sequence ID" value="XM_022013011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTJ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTJ5"/>
    <dbReference type="GeneID" id="33554819"/>
    <dbReference type="InParanoid" id="A0A1Y1UTJ5"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="347" mass="39653" checksum="25CA9952DA9FE6AD" modified="2017-08-30" version="1">MPDKLGRKSRPVRTLRSATTYRQKKSIYASPSVAGSTSSLGRRLIVRRTDSGGKGKARAVSEEVDDEDFDELAEDDDEHDEDVDELADDEDLSMVKAEYRERAERAWETRRENERIRAELREQRLVSPALDLDLPSDDLLNGIHFHASKFYTAHSLILKPQKQVRRRQWGSKKRMLLQTEGIAPIERNGLDKDFWVHLKPIKRRRVMSVPSWAVQEDDSDWDEQSGSDNTGERTEETGEEEEEDSESQAESHGRAQPNVVDLAERRRPDQAPKRGYRKQYKQRDMFKSLDGTALLAMGFLVERFIARELARAGYQPKMESADRAASAASRHHIEAGEDDEAGDLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTK7</accession>
    <name>A0A1Y1UTK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thaumatin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_19891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874445.1">
        <property type="nucleotide sequence ID" value="XM_022012159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTK7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTK7"/>
    <dbReference type="GeneID" id="33553967"/>
    <dbReference type="InParanoid" id="A0A1Y1UTK7"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000011">
        <property type="entry name" value="Thaumatin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012779093" evidence="2">
        <location>
            <begin position="23"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="424" mass="44410" checksum="FCD394156D59F79E" modified="2017-08-30" version="1">MLFLEIAFQFTSLLMASQVVFSRKITVKNSCKTTVWPGMHTGGGTAPDHVTGWEAVPGSEETFEVADNWTAGRIWARTGCVVQDGNFQCLTGQCGSGEGGDMTCMNTNTPPSTLAEFTLATAGEDNYDISLVDGFNVPLNIILSKSDCPQPTCMGNINPLCPPLLRTGLDSNGVNLGCLAACNAGFGAETYGNRACCTGSYNDPIMCGICGVDYYSLFKDNCNMSYAYAYDEKSESALWTCPSSPGSLSDYTIEFCPDGRDYVGSRFAGTEYLDATAKCTSQATSGPQTFSVPPSPSTTIAQGTLQVVATVATGLDGAAAIEIRPSPPPVSAATSPNAAAAVTSSAPAVVSGARLSLASSADQVVVVWETKTSTAIKTAGCKASAPAAVNLLLHPNEDEAVRGGQWLAPQKRAQKRSNRMTRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTM9</accession>
    <name>A0A1Y1UTM9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_612721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874646.1">
        <property type="nucleotide sequence ID" value="XM_022014428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTM9"/>
    <dbReference type="FunCoup" id="A0A1Y1UTM9">
        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTM9"/>
    <dbReference type="GeneID" id="33556236"/>
    <dbReference type="InParanoid" id="A0A1Y1UTM9"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="529" mass="58005" checksum="35DED6302967BD49" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTV3</accession>
    <name>A0A1Y1UTV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_612708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874643.1">
        <property type="nucleotide sequence ID" value="XM_022014426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTV3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTV3"/>
    <dbReference type="GeneID" id="33556234"/>
    <dbReference type="InParanoid" id="A0A1Y1UTV3"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="82"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="479" mass="55950" checksum="ACC73DB3D6ED1D37" modified="2017-08-30" version="1">MRVPSPIMHDANDYLQIKGDDIVLDGKPILLKGAGLGGWMNMENFITGYPGHEFQVRAALKKVLGEEKYDFFFDKFLEYFFTEEDAKLYAELGLNCLRLPVNYRHFEDDMNPRVFKKEGLKHLDRVIDICAKYGIYTVIDLHAAPGGQNCDWHSDAGNDQALFFDHKDFQDRTVLIWEHLAKHYRDNTWVAGYNPLNEPTDEQHVRLLAFYKRVEKAIRKIDPHHLLFLDGNTFGGDFRHFEEPLPNCVYACHDYSNYGFPSAPELFTGTPEQIEWHKRSFNRKIEYMQKHKIPIWNGEFGPVYQNANDGLPNWEEINESRYKVLECQLGLYANAKTSWSIWLWKDIGFQGMTYVDPESPYIKLLQPFLDKKRRLATDSWGCDTTPVEPIFEPINKWMLEAAPALEHKYPSTWRGVKHISRMLRNCLLSECLVDEYASYFEGKSMQELDELAQSFKLSKCQQRTRLNDILKEDSKRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUS0</accession>
    <name>A0A1Y1UUS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874895.1">
        <property type="nucleotide sequence ID" value="XM_022014526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUS0"/>
    <dbReference type="GeneID" id="33556334"/>
    <dbReference type="InParanoid" id="A0A1Y1UUS0"/>
    <dbReference type="OrthoDB" id="2562172at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="404" mass="46232" checksum="72EF3B0223C7689F" modified="2017-08-30" version="1">MLMSLRANIYTALIVPAVLIVLLLVWHNDSYDPKTLLSLGNHPSGGVPNVHLFFPVDKRSAESEDGSVVFCKTIQGAVVNGWTPILFNWEVESEHQMRKVQGLRDLLDSPVHTAGFEEDDLILMMDAFDVFIQLSPEVAARRFTEYGDVDVMAAAEKNCYPNDPNGHICQDAPWSPLHNGPNANLYRPNDDPNRPYDQEETLPRHVNSGTVIGKLSKMRTFYNELWDFMLSDTYEGWDDQGAFGIFLTDQPVKTRLSVDYHSRLFWPGFQDFQNIRFMGTHYPPDPSTAASYSDPEASDYIPWDLYPMLAHHRKTGEVPVALHFNGPIKELINEWWGQLWWSSQRDRFLPIIHQRMSQGKVLIAIPEGYREMPVQELCPHMDIWQWQSSHQTTDGRGSSVAQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5Q7</accession>
    <name>A0A1Y1U5Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_640191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000026">
        <property type="protein sequence ID" value="ORX33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867673.1">
        <property type="nucleotide sequence ID" value="XM_022017328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5Q7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5Q7"/>
    <dbReference type="GeneID" id="33559137"/>
    <dbReference type="InParanoid" id="A0A1Y1U5Q7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20156" checksum="DC2666F0E2305B04" modified="2017-08-30" version="1">MLNRCSTRMGTINHYILTPNGNGIQSCRILPFALETSRVCMLPRPAHQSNFLILHQLGAAKHSGHHFRLLPDCKYHTNIELKRSWEATEEMMSKGLGPDTWAAVVEALTAILHLGNVTANNFKAIEDASLGLGVTSAELADYLLKSALPEGSRKSSEQVTVTRDAMIKALYRALLDVSMRTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6I8</accession>
    <name>A0A1Y1U6I8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome oxidase complex assembly protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867960.1">
        <property type="nucleotide sequence ID" value="XM_022017185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6I8"/>
    <dbReference type="GeneID" id="33558994"/>
    <dbReference type="InParanoid" id="A0A1Y1U6I8"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="28489" checksum="4F39D8F5E3946C4E" modified="2017-08-30" version="1">MLSRSFVQSQRLLSRGLITPAPCRSFAAHPRKPLESTTFSDKSSPREVYERPETSRGMPPEGAPSFSKRAIEGDDSKEMTLEEAFSGPSRPRLVYAVPSRKTKELPRLGTKVPLYILLGTLGLSAWGIFLLYATNAERLASSAMRSVQFHLRHSPDVSALLGKRVRLEEPPWFIGDPWISGTVNTMQGRIDLSFRVRGDDASGTIYFTSIRPHQGDPWRILRYKLITDSGTTVRLEDKIERITDNSAVEKQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U861</accession>
    <name>A0A1Y1U861_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_637151</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868499.1">
        <property type="nucleotide sequence ID" value="XM_022016972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U861"/>
    <dbReference type="FunCoup" id="A0A1Y1U861">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U861"/>
    <dbReference type="GeneID" id="33558781"/>
    <dbReference type="InParanoid" id="A0A1Y1U861"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="282"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="890"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="815"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110082" checksum="826B249F1F445326" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8C2</accession>
    <name>A0A1Y1U8C2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_638609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868093.1">
        <property type="nucleotide sequence ID" value="XM_022017136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8C2"/>
    <dbReference type="FunCoup" id="A0A1Y1U8C2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8C2"/>
    <dbReference type="GeneID" id="33558945"/>
    <dbReference type="InParanoid" id="A0A1Y1U8C2"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="297"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="583" mass="64443" checksum="17819DD0C559926D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8F1</accession>
    <name>A0A1Y1U8F1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_638704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868113.1">
        <property type="nucleotide sequence ID" value="XM_022017148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8F1"/>
    <dbReference type="GeneID" id="33558957"/>
    <dbReference type="InParanoid" id="A0A1Y1U8F1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012417705" evidence="1">
        <location>
            <begin position="28"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="305" mass="32779" checksum="679071841AF7BA2F" modified="2017-08-30" version="1">MKPSLSVPKLLSLTFFVLLLTLTSGDAIRLWDPSARREPAKSLGAQSRQCSTNAECLRLGSPIRKQDVTGGAKVHKRASVTMTTGTTTTLSPKPTPSKFSTSIAVFASYNSSFLGYISRSNVAPDGVLLPFFSGFDVSDYRSAPSFPSDGGSQDSQYLQVIVDVTPHETTYGHNITFPWSGTPPAYFLCAFMYAIARTRDINQPYAQAYLSACNSQGIGTTQAGSPPALGENAIWTIDGTSGELSAVWEQPSGELLPLTCYYDPGIPTAGVPPSFVFVNGEDIYGNNGAFKIVSIFSQRELLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8L9</accession>
    <name>A0A1Y1U8L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868636.1">
        <property type="nucleotide sequence ID" value="XM_022018619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8L9"/>
    <dbReference type="GeneID" id="33560428"/>
    <dbReference type="InParanoid" id="A0A1Y1U8L9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="152" mass="16737" checksum="82DBC7ADEA951F2D" modified="2017-08-30" version="1">MSTVSEDSTPDGQSHSSTTHAQEEEIPQPPPEDVWNPPDSEEEWDSRSRAASDDDGEDESSVRSQEEDESNTKTGSVEATHPTLEQARSNLRTLSYVEMADEELGDGQARSFDSRRPRGRLASLDLPTIPEDEVSRESSVVRSVQCNESDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8V2</accession>
    <name>A0A1Y1U8V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_637857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868262.1">
        <property type="nucleotide sequence ID" value="XM_022017057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8V2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8V2"/>
    <dbReference type="GeneID" id="33558866"/>
    <dbReference type="InParanoid" id="A0A1Y1U8V2"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="835"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="864"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127846" checksum="2D83A24EFD0FACE8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8V5</accession>
    <name>A0A1Y1U8V5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_635973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868711.1">
        <property type="nucleotide sequence ID" value="XM_022016849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8V5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8V5"/>
    <dbReference type="GeneID" id="33558658"/>
    <dbReference type="InParanoid" id="A0A1Y1U8V5"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011832835" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="61"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="570" mass="63186" checksum="FF953DF7CD04C62B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9D9</accession>
    <name>A0A1Y1U9D9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_634336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868890.1">
        <property type="nucleotide sequence ID" value="XM_022016717.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U9D9">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9D9"/>
    <dbReference type="GeneID" id="33558526"/>
    <dbReference type="InParanoid" id="A0A1Y1U9D9"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="999"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="874"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1344"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1344"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1404" mass="154393" checksum="FB54319C67C7870B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9H4</accession>
    <name>A0A1Y1U9H4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PPPDE putative peptidase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_634400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868904.1">
        <property type="nucleotide sequence ID" value="XM_022016722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9H4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9H4"/>
    <dbReference type="GeneID" id="33558531"/>
    <dbReference type="InParanoid" id="A0A1Y1U9H4"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="184"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="331"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="632" mass="68809" checksum="591A1B41963EA2E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9I9</accession>
    <name>A0A1Y1U9I9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_609884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868945.1">
        <property type="nucleotide sequence ID" value="XM_022014176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9I9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9I9"/>
    <dbReference type="GeneID" id="33555984"/>
    <dbReference type="InParanoid" id="A0A1Y1U9I9"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="99858" checksum="ABC03866A0334EED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9P6</accession>
    <name>A0A1Y1U9P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_609913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868991.1">
        <property type="nucleotide sequence ID" value="XM_022014179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9P6"/>
    <dbReference type="FunCoup" id="A0A1Y1U9P6">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9P6"/>
    <dbReference type="GeneID" id="33555987"/>
    <dbReference type="InParanoid" id="A0A1Y1U9P6"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="336"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="685" mass="75597" checksum="1B01057D6D2E4A4C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9S0</accession>
    <name>A0A1Y1U9S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_653039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869023.1">
        <property type="nucleotide sequence ID" value="XM_022018594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9S0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9S0"/>
    <dbReference type="GeneID" id="33560403"/>
    <dbReference type="InParanoid" id="A0A1Y1U9S0"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000482">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="378"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="378"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="888" mass="96607" checksum="CCF070F41D6B07B4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9T4</accession>
    <name>A0A1Y1U9T4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_635039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869035.1">
        <property type="nucleotide sequence ID" value="XM_022016777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9T4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9T4"/>
    <dbReference type="GeneID" id="33558586"/>
    <dbReference type="InParanoid" id="A0A1Y1U9T4"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="225"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="514" mass="56681" checksum="6423C03DD1051F54" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9U9</accession>
    <name>A0A1Y1U9U9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_605148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868565.1">
        <property type="nucleotide sequence ID" value="XM_022013995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9U9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9U9"/>
    <dbReference type="GeneID" id="33555803"/>
    <dbReference type="InParanoid" id="A0A1Y1U9U9"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="117"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="496" mass="53272" checksum="CD27916CBB242894" modified="2017-08-30" version="1">MSGRLFLSAAFQRRLARTPLRRKLSWSSTSSPLVPATSTSSSSSSSPSSSRFFSTSSVSSAKRDALRLPRSERPAVSVGPVRPILSEDIDLPSQPPDSALAVLLSRMTLDPDPALYPSVLACLTHPSYANTPYQSGDSTPSPQPSTSSSSSSSAAAQNTKEYNNELLSATGNSLLGLFAAEFLANRFPFLPTEPLKSAVTAYVGPAACVSVARELGIGVRHGADAGEFAMGQPSASAGVPIRWERMTLEREEAMIYPSARFNKMLKAEGDRWASKVETPSGMALDPDQSRRVKYAEQWTDVVASVMRAFVGLIYEQKGLHDAREFVHAHFFSRHLDLTTLFNFRNPKLVLAAVVERHMAEAGINKASGQTKIQPRLLASTGVATMAPLFNIGLFLPSGLKLAEGTGSSKAMAEHRASVNALMSLYLVRGDVSRVAGQNVSNLLPSMAHSPTPIGENGLETEETGEKGYKGKGFGGLETNVENSKRSQMRGRLLQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9X7</accession>
    <name>A0A1Y1U9X7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868173.1">
        <property type="nucleotide sequence ID" value="XM_022017022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9X7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9X7"/>
    <dbReference type="GeneID" id="33558831"/>
    <dbReference type="InParanoid" id="A0A1Y1U9X7"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="104" mass="11736" checksum="68E53DD04D1AA96B" modified="2017-08-30" version="1" fragment="single">MRICVKTMKGYSIQLLVNPGDTVEQIKAMIFFMGELPACTQRLVCFGRQMQDYFTLSHYGFDQDGIVVIHSARWLCRSLYSMSGPVKGNVLLYACGRGTSRMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9X9</accession>
    <name>A0A1Y1U9X9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_583230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869093.1">
        <property type="nucleotide sequence ID" value="XM_022013608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9X9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9X9"/>
    <dbReference type="GeneID" id="33555416"/>
    <dbReference type="InParanoid" id="A0A1Y1U9X9"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11332">
        <property type="entry name" value="AmyAc_OligoGlu_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="18"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="566" mass="63432" checksum="232B559C624D508A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA52</accession>
    <name>A0A1Y1UA52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_653163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868649.1">
        <property type="nucleotide sequence ID" value="XM_022018622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA52"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA52"/>
    <dbReference type="GeneID" id="33560431"/>
    <dbReference type="InParanoid" id="A0A1Y1UA52"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6710" checksum="CD669F48F21D68E7" modified="2017-08-30" version="1">MMGARPLLPPAPLFHRVLAKGMGATMWFFVFYRARQDGAVMLGWRHPWEGHGHDDDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA59</accession>
    <name>A0A1Y1UA59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_103788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869124.1">
        <property type="nucleotide sequence ID" value="XM_022011914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA59"/>
    <dbReference type="GeneID" id="33553722"/>
    <dbReference type="InParanoid" id="A0A1Y1UA59"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115669" checksum="955584CF78A04877" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAE9</accession>
    <name>A0A1Y1UAE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutamine synthetase</fullName>
            <ecNumber evidence="4 13">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_582605</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869226.1">
        <property type="nucleotide sequence ID" value="XM_022013569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAE9"/>
    <dbReference type="FunCoup" id="A0A1Y1UAE9">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAE9"/>
    <dbReference type="GeneID" id="33555377"/>
    <dbReference type="InParanoid" id="A0A1Y1UAE9"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="111"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="39322" checksum="B17BE0FB8E979328" modified="2017-08-30" version="1">MSELIATKRVDLLAPYLALPQGSKVQAEYIWIDGDGGLRCKTMTLDQKPSAVSELKEWNFDGSSTNQAPGNNSDVYLRPVAMFKDPFRGGDNILVLCECYDNDGTVNASNYRAHCKKVMDAAKEHEPWFGLEQEYTLFDADGQVFGWPKMGFPGPQGPYYCGVGAGRVFARDFIEAHYRACLYAGVKISGINAEVMPSQWEFQVGPCEGIEMGDHLWMARFLLLRIGEEWGIKPSLHPKPLKGDWNGAGCHSNFSTVEMRTPGKGMAAIEAAIKKLEAKHLEHIAVYGEDNEQRLTGKHETASIGQFSAGVANRGASIRIPRHVGAQGYGYLEDRRPASNVDPYRVTAILVETTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAM4</accession>
    <name>A0A1Y1UAM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_633845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869299.1">
        <property type="nucleotide sequence ID" value="XM_022016667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAM4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAM4"/>
    <dbReference type="GeneID" id="33558476"/>
    <dbReference type="InParanoid" id="A0A1Y1UAM4"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72112" checksum="14352BCD336A930E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAM6</accession>
    <name>A0A1Y1UAM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_652813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869314.1">
        <property type="nucleotide sequence ID" value="XM_022018558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAM6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAM6"/>
    <dbReference type="GeneID" id="33560367"/>
    <dbReference type="InParanoid" id="A0A1Y1UAM6"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="85" mass="8915" checksum="DD5361797826D597" modified="2017-08-30" version="1">MSYVIAGKSIKNEYLALGTILLTGGGAYAYKASQSSKPVVPKPAAASSSSSSNTDSDLGITTDSKDELDFIRQFVADAEKEGKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBN7</accession>
    <name>A0A1Y1UBN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869163.1">
        <property type="nucleotide sequence ID" value="XM_022018532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBN7"/>
    <dbReference type="GeneID" id="33560341"/>
    <dbReference type="InParanoid" id="A0A1Y1UBN7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="458" mass="53845" checksum="5533CBF64A377FB8" modified="2017-08-30" version="1">MPETDSAADSKVALTPSSLSLPSSRPPLKRSRRSGSGEDVSKHNDNIRPELDHHALPFAPHSERRAIWADLLRMEIVELRIQLDESNEECKRVMESRDSLRALLESSNTMADRWKAETFRQAEETERLKVQAEVASTRWRGEEGRLTKELALVTSEARTLKASRNDREVRISSLTRALKVEKEARLVLEAKIEEGMKLERLKAEDLSRERQVYEARPKEVRSRLDTDWTLLRTERQNLAKAELRFVDQIHIHQLQMEVQRLRELSHAKGKEDSMGAEELANLRRRMTSTRGLVFDLKKEARDQSRYVVQLERVIDEKLKDCEHWKALNDTKISEIERAAMEGRCKVMQQNFSRVQRHLQGLQDYHDVAWREKRDTDIIQMEEDMIRRFEDKATENLRINETMCEITIGERMTWDRNLRKTSQMEEMRRLEYWLDEPEIVDGEMRLTSTDPEENEDNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBP1</accession>
    <name>A0A1Y1UBP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869629.1">
        <property type="nucleotide sequence ID" value="XM_022018517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBP1"/>
    <dbReference type="GeneID" id="33560326"/>
    <dbReference type="InParanoid" id="A0A1Y1UBP1"/>
    <dbReference type="OrthoDB" id="2576310at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012575874" evidence="2">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="202" mass="20310" checksum="F36CFFE2D974677F" modified="2017-08-30" version="1">MRTFVIGILALASTALAQIETITLPNGNTVVISVGTNALGDEFTTTLNSALVVGGAAAETNTKTNTKTTTTVNNAVEGGAPTTTTGPRVVGVETTAPPMRTTTYWYDPGDGVWISQIWTASITAAPTVATAIVPAGTIQNYNSYQTQINSVVLKSAEAAEAASSGQVSGNIGAARRGVQEQAAGLVAAVVGFVGLGVGLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBP8</accession>
    <name>A0A1Y1UBP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_106915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869170.1">
        <property type="nucleotide sequence ID" value="XM_022011923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBP8"/>
    <dbReference type="FunCoup" id="A0A1Y1UBP8">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBP8"/>
    <dbReference type="GeneID" id="33553731"/>
    <dbReference type="InParanoid" id="A0A1Y1UBP8"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="658"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="760" mass="83217" checksum="77A48ED2DB88F67D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBY7</accession>
    <name>A0A1Y1UBY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_630636</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869722.1">
        <property type="nucleotide sequence ID" value="XM_022016347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBY7"/>
    <dbReference type="FunCoup" id="A0A1Y1UBY7">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBY7"/>
    <dbReference type="GeneID" id="33558156"/>
    <dbReference type="InParanoid" id="A0A1Y1UBY7"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="236"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="573"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="756" mass="80525" checksum="38F295F4543BD1A2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC41</accession>
    <name>A0A1Y1UC41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_609369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869767.1">
        <property type="nucleotide sequence ID" value="XM_022014154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC41"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC41"/>
    <dbReference type="GeneID" id="33555962"/>
    <dbReference type="InParanoid" id="A0A1Y1UC41"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="794"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="988" mass="111023" checksum="C8C12449325883F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC80</accession>
    <name>A0A1Y1UC80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869783.1">
        <property type="nucleotide sequence ID" value="XM_022016377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC80"/>
    <dbReference type="FunCoup" id="A0A1Y1UC80">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC80"/>
    <dbReference type="GeneID" id="33558186"/>
    <dbReference type="InParanoid" id="A0A1Y1UC80"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="400" mass="45226" checksum="B7305B89760A3305" modified="2017-08-30" version="1">MGRMAEAQRRLLEQMMGPEAMGYVVVNLDWWDEKVCRNFLFGTCPHLIFGNTRMDLGPCPKTHSDRILKQFQEHMAAHPNDPRIAAFRQEHENTIHGFIEDCDRRIRASQRKLEKTPEENRKTIDLMKEIGEIELSIQGGTEEIEALGEAGKVEESMEKLAAVDALKNLKADKEKELQDLNETAGASGHQKLRVCETCGAMLSMLDSDKRLADHFGGKLHLGYNELRLLLAKFAEDRMTGRTASNAPAAPTSAPPANAPAGPAGPRPNPPLFAPSGPSGPRGSRPDGPGSSPAPHTPHDGPRVPPSDEMPAVGHGDKVKREAGELVEDIKESRSRRDSDASGMDRDRYRERERSDRDRERDRDRERDRDREKDRDRYKERGDGERDRHRDERYDKYDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCK2</accession>
    <name>A0A1Y1UCK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_74669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869903.1">
        <property type="nucleotide sequence ID" value="XM_022019235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCK2"/>
    <dbReference type="GeneID" id="33561044"/>
    <dbReference type="InParanoid" id="A0A1Y1UCK2"/>
    <dbReference type="OrthoDB" id="2596559at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="75731" checksum="F51C34E9717B4511" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCM6</accession>
    <name>A0A1Y1UCM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps53-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_631786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869972.1">
        <property type="nucleotide sequence ID" value="XM_022016464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCM6"/>
    <dbReference type="FunCoup" id="A0A1Y1UCM6">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCM6"/>
    <dbReference type="GeneID" id="33558273"/>
    <dbReference type="InParanoid" id="A0A1Y1UCM6"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.110:FF:000004">
        <property type="entry name" value="Vacuolar-sorting protein 53 long isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="627"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="747"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="809" mass="90342" checksum="73C6952A4F5E1FB1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDE4</accession>
    <name>A0A1Y1UDE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870207.1">
        <property type="nucleotide sequence ID" value="XM_022016291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDE4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDE4"/>
    <dbReference type="GeneID" id="33558100"/>
    <dbReference type="InParanoid" id="A0A1Y1UDE4"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="427" mass="45840" checksum="F627698F11D7AA36" modified="2017-08-30" version="1">MAHPLTQHPPSSLPFATAARPSPVAFGFGQPSSFSAFSNGQFSTFGRPLNANPNAFPALNPPPSGSGSGSSFVGPISSSPSKRFTRPSPIGFKSQPTLKRTRKSSSSSESTPPSPRTLSSSPSHAGLELPRTKDDLSRLDLSEGMRGTPGRKVMKRFRSEAGPSTGTDASQTQDVGVLLATLPPSSHLDILMGIVRRHPALASEILAELPQPDLDECVNQLDKILSRIRRKTSAGVADPARVWPRIQDDVSAYCRTASTYVSFFSSSSPSPDPGTMQALLFTITSEVYTLLQLVPSDVAASNSVATLLELGKVLVSTWTNWVNGIATEVNQRGGMYPRSLVEGWVANIESLANWQSTRSLSSFGHPVLGTHPLVESFKSALQTTLETFINEVGWLIDRRSQFSAGPSLHHMPQVPVWSQPFIRPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDM7</accession>
    <name>A0A1Y1UDM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_526478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870270.1">
        <property type="nucleotide sequence ID" value="XM_022012998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDM7"/>
    <dbReference type="GeneID" id="33554806"/>
    <dbReference type="InParanoid" id="A0A1Y1UDM7"/>
    <dbReference type="OrthoDB" id="10670504at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="29517" checksum="41485190BE3C3671" modified="2017-08-30" version="1">MPVASPGPMGSDHPSAICLPLLVLPISPPNGTPYDRPARPRLRIVTAQGSTPPPQIVKTAPIIVSNDPTLSFTFPSKSSVASLAHEDTASYTLLSPPKPTSRSARLKRPAHVGHARKLSDKFKSLFSALHIKRDDRIPFFQPGMVSTDILNDCEYLTPLRPHPSPGTASFLVSRHLAPDPNLPTSAHSSSTAFSIASRPTFASKYRATYDSHGAISHFSNPTTLSSAASSMGGRSVSSSVILDKSPGLGKRMALDEGVRLNARIRRCRSLPDMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDW5</accession>
    <name>A0A1Y1UDW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_627906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870313.1">
        <property type="nucleotide sequence ID" value="XM_022016060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDW5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDW5"/>
    <dbReference type="GeneID" id="33557869"/>
    <dbReference type="InParanoid" id="A0A1Y1UDW5"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="189" mass="20773" checksum="E670C7CADB3FB654" modified="2017-08-30" version="1">MYTLPGISLDPCADMTSVQPKAGTELPLSGLTRDGWSNADEATATCSCGAIQMVLPIKAPGLVNTFVCHCSDCRNWSASVFATNLTTLDSHTRFVRGEDHLVLFSQSETISKHRRMTNAFCKLCGTLMYRQGAVGPGTRFMRGGPIDDHELHNTILKPQWEIFTEHRASWIPAVPGARQEIGMGDFDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDW9</accession>
    <name>A0A1Y1UDW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_652414</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869465.1">
        <property type="nucleotide sequence ID" value="XM_022018488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDW9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDW9"/>
    <dbReference type="GeneID" id="33560297"/>
    <dbReference type="InParanoid" id="A0A1Y1UDW9"/>
    <dbReference type="OrthoDB" id="2589805at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012869700" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="24"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="268"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="643" mass="70233" checksum="E38ED059074330F5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEC6</accession>
    <name>A0A1Y1UEC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_628666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870489.1">
        <property type="nucleotide sequence ID" value="XM_022016133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEC6"/>
    <dbReference type="FunCoup" id="A0A1Y1UEC6">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEC6"/>
    <dbReference type="GeneID" id="33557942"/>
    <dbReference type="InParanoid" id="A0A1Y1UEC6"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="276" mass="30421" checksum="656BFBF3CC4E4474" modified="2017-08-30" version="1">MALRFAPHQKNSIHRTLSKQPNHTLVDTMTDSSTSACCNLPPVEAKYTNKGEETQFCDIKTYITGPKDAKEAIFILYDVFGMAPQTLQAADLLASQGFRVYVPDLLMGEYVKPEWYSGSEEGNQKRQEYFSRFPGSTSSQSEQVSKVITAIKAAGQDKIGLVGLCWGWKAAVLAKELNQASALAGNHPSMTAKDDVEKIDIPVLLQPSKNEDAEIMKAIYEGMEKKLPGKNKLTEFPNSAHGWTAARADLESEEGRKTYSDAWSGVASFFKTHLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEG3</accession>
    <name>A0A1Y1UEG3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_580694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870551.1">
        <property type="nucleotide sequence ID" value="XM_022013454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEG3"/>
    <dbReference type="FunCoup" id="A0A1Y1UEG3">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEG3"/>
    <dbReference type="GeneID" id="33555262"/>
    <dbReference type="InParanoid" id="A0A1Y1UEG3"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="168" mass="18561" checksum="C849D4A19FFFE58C" modified="2017-08-30" version="1">MSTALRAFDFLKLRTVAFSLPQNLCTHLQNVSRSTLARTSVPYTQSSLTICAILLRHGLISNMTLGDPTAADPTNFRRLSPPQKRIWLGLKYRNGIPVLRNMSLISKPSKRIYATKDELGRILTGRRAVNVAGVGIGEILVVKTPDTLMEGWEAWRAGLGGELILRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEG6</accession>
    <name>A0A1Y1UEG6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cohesin loading factor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_580804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870552.1">
        <property type="nucleotide sequence ID" value="XM_022013463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEG6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEG6"/>
    <dbReference type="GeneID" id="33555271"/>
    <dbReference type="InParanoid" id="A0A1Y1UEG6"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="67456" checksum="1B38C79E806555F6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEH9</accession>
    <name>A0A1Y1UEH9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_512129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870066.1">
        <property type="nucleotide sequence ID" value="XM_022012963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEH9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEH9"/>
    <dbReference type="GeneID" id="33554771"/>
    <dbReference type="InParanoid" id="A0A1Y1UEH9"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="242"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="614" mass="67264" checksum="3AB3319D3EB90A04" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEJ6</accession>
    <name>A0A1Y1UEJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_651682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870543.1">
        <property type="nucleotide sequence ID" value="XM_022018373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEJ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEJ6"/>
    <dbReference type="GeneID" id="33560182"/>
    <dbReference type="InParanoid" id="A0A1Y1UEJ6"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="236"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="295" mass="31269" checksum="7AC1E8A2B129D83C" modified="2017-08-30" version="1">MLNDFSTGHVLSHPLFLVTFALAFPAWIIAFAGQIAAEAQFDSSIRGNSEPVCKYLWYSIWIQLAVTIHLFLAICTDQLAIHRFQIAVFAAIAEVFSIYGANFLFDSAGSLISVGVGWLLIAIVDLIWILYLTSEEGTLFHNLLSFGGRGGASVGPRHSVRTPKGVANYEADSGLGAGVASSGNGNITGQNGGAYASVPAANTAIPYGSAGPEHGAPQFGQVGDLSGQPTDTVQHPTVQRAKAMYAYNANPDDPNEVSFAKGDLLEVIDNTGKWFQVRTPSGQTGIAPSNYLTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEY9</accession>
    <name>A0A1Y1UEY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase II transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869799.1">
        <property type="nucleotide sequence ID" value="XM_022016386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEY9"/>
    <dbReference type="FunCoup" id="A0A1Y1UEY9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEY9"/>
    <dbReference type="GeneID" id="33558195"/>
    <dbReference type="InParanoid" id="A0A1Y1UEY9"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10208">
        <property type="entry name" value="ASKHA_NBD_ScArp9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000411">
        <property type="entry name" value="RNA polymerase II transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="480" mass="51822" checksum="0061582B47B79AFE" modified="2017-08-30" version="1">MNVNFRDAPPTILHVDEQVIRAGKGISDLFPSPSVTIQARYAVPRSHGNGDVSMTDGQGEGSSSSANWIVGQGLDAAQSELSFEEKWEVRWPFRSSKRAEDWVGREYILQHVFTLLDIKVSANPSPLMLIPPSDLSLDASALYTQLAFEELNVPGLTILSLPLASLYALGALSGIIIHIGAEQSNVSIVTESIVRDECTTRIPIGLTHCLAHLERLLLIDFALDKELRMARGSGDSEPWSAGEKERLVKEVITVLWMENASEIEAPTSTGEVMHKVREEAETDDTFDVAKKLVGDAAPAPQPKKKAPAPTAGATDTISISIPSFAEKTITIGPIRHKLCEPLLRGINGQESLWEAVGRAVESPGLIPAERMAIWDGIGVVGEMAKIKSFAPAFVTYLSPLLLSSAEIPSDVQPAKARLLSIPDYFANFKGNSTDMAPFLGGSMVAKYAFSDYAGKHCITKVDYNAKGPAAIYTAGIGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF63</accession>
    <name>A0A1Y1UF63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_630367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870275.1">
        <property type="nucleotide sequence ID" value="XM_022016320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF63"/>
    <dbReference type="FunCoup" id="A0A1Y1UF63">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF63"/>
    <dbReference type="GeneID" id="33558129"/>
    <dbReference type="InParanoid" id="A0A1Y1UF63"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="234"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="418"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="819"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="820"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="903" mass="99720" checksum="EDBB7F11C8460EDC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFJ7</accession>
    <name>A0A1Y1UFJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_627210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870871.1">
        <property type="nucleotide sequence ID" value="XM_022015975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFJ7"/>
    <dbReference type="GeneID" id="33557784"/>
    <dbReference type="InParanoid" id="A0A1Y1UFJ7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="55" mass="6020" checksum="6430B2241186B213" modified="2017-08-30" version="1">MSSAVAVAAAATAVAVFSFLKDTIDIIISRHRIPPIQYYYYSIHLSILVALIIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFQ7</accession>
    <name>A0A1Y1UFQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_628544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870468.1">
        <property type="nucleotide sequence ID" value="XM_022016125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFQ7"/>
    <dbReference type="FunCoup" id="A0A1Y1UFQ7">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFQ7"/>
    <dbReference type="GeneID" id="33557934"/>
    <dbReference type="InParanoid" id="A0A1Y1UFQ7"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="197" mass="22275" checksum="4BDA78CCCEEE9061" modified="2017-08-30" version="1">MSTHHQRQHPIILITGTPGTGKTLHSHLLEAETASSSSPLKHLNIGDIVKQHGLHEGWDDEWQSYTVDEDRLLDYLEEVVNPEAGPSTTGFILDHHDPSLFPERWVDLAVVLTCDNSILHERLTARKYPEAKVTENITAEIMMTCLTETKESYAEEIVVELKSDGSGGDKEVQENVSRIEAWAEQWREDRLSGKHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG24</accession>
    <name>A0A1Y1UG24_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_421262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871041.1">
        <property type="nucleotide sequence ID" value="XM_022012730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG24"/>
    <dbReference type="GeneID" id="33554538"/>
    <dbReference type="InParanoid" id="A0A1Y1UG24"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="543" mass="60298" checksum="5A77DE67D9D6125E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG53</accession>
    <name>A0A1Y1UG53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_580340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871028.1">
        <property type="nucleotide sequence ID" value="XM_022013435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG53"/>
    <dbReference type="FunCoup" id="A0A1Y1UG53">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UG53"/>
    <dbReference type="GeneID" id="33555243"/>
    <dbReference type="InParanoid" id="A0A1Y1UG53"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="299" mass="32952" checksum="361A50B3C7FEE2E6" modified="2017-08-30" version="1">MPFKPVQLNDGRYLPTIGFGTWKIPKENCASQVDQAVDVGFDHIDTAQAYRNEEEVGQAIKEQGLARKDFWLTTKWSGVDGKQPKQSCEESLEKLGVEYLDLYLIHSPRLCQGDIPGSWKQMEDLYREGKVKSIGVSNFSVEDLQTLLASCSIKPVVNQILLHPYVIGRTEPLLEFHAAQHIVTEAYSALFPLTSQPGGPVDKPLNKIAEKHGVKPEQVLIAWASAKKAVVLTTSRTKERLEGYLAAGDITLSEDDIAELDKAGKKGEQKQVMVKKARTVGRVVLAGAAVYAALRLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGF1</accession>
    <name>A0A1Y1UGF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_580049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870655.1">
        <property type="nucleotide sequence ID" value="XM_022013423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGF1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGF1"/>
    <dbReference type="GeneID" id="33555231"/>
    <dbReference type="InParanoid" id="A0A1Y1UGF1"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="701"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="865" mass="97413" checksum="694DD4D2E19A3749" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGL1</accession>
    <name>A0A1Y1UGL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX37162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871200.1">
        <property type="nucleotide sequence ID" value="XM_022015755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGL1"/>
    <dbReference type="FunCoup" id="A0A1Y1UGL1">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGL1"/>
    <dbReference type="GeneID" id="33557564"/>
    <dbReference type="InParanoid" id="A0A1Y1UGL1"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="346"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="451"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="535"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="622" mass="67651" checksum="46294237D9378002" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH41</accession>
    <name>A0A1Y1UH41_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative chromatin remodelling complex ATPase chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_628726</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870506.1">
        <property type="nucleotide sequence ID" value="XM_022016140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH41"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH41"/>
    <dbReference type="GeneID" id="33557949"/>
    <dbReference type="InParanoid" id="A0A1Y1UH41"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000382">
        <property type="entry name" value="Transcription activator snf2l1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="231"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="528"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="16">
        <location>
            <begin position="884"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX36405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1113" mass="127557" checksum="E066C872C9D263B6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHJ1</accession>
    <name>A0A1Y1UHJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_626313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871497.1">
        <property type="nucleotide sequence ID" value="XM_022015882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHJ1"/>
    <dbReference type="GeneID" id="33557691"/>
    <dbReference type="InParanoid" id="A0A1Y1UHJ1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="80" mass="8493" checksum="F3044A17CDBCEEE8" modified="2017-08-30" version="1">MAPSFEVSPLKCCCVTPSLSWPSMLVLAFDAMDVSGAYTVNCCVCTVFMGHPHIAHLASLPPTSLSFLVTDPPAQPPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIC9</accession>
    <name>A0A1Y1UIC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_625393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871282.1">
        <property type="nucleotide sequence ID" value="XM_022015795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIC9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIC9"/>
    <dbReference type="GeneID" id="33557604"/>
    <dbReference type="InParanoid" id="A0A1Y1UIC9"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="296" mass="33300" checksum="6B6F2F92B8A8A13A" modified="2017-08-30" version="1">MMSATASRSTRRNPLDSFVLDPSLDSATLDSLDDPNVDPTLADQSRLSDLAQHVVKSGTDDAASLLAFSTGDEGLFEPSVQHQGFNELMEAAERTHQEMEHVEQEEQEEQEEQEEQEQQMDVQEEIATEDDVRPRRLPDAPRGRKRKSRDGGEDDTAESTRLKKDSHKEVERRRRENINDGINEIAKHVPGGGEKMGKGTFLRRAAEYLGELSARANIHDAEMAKKEEERSNAQADLAHVQAQLAEEQARALRLEKSFQEADDRAAQTQFQLSIAKSELDLVKKQLEDAQAELSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIK0</accession>
    <name>A0A1Y1UIK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA protein C-terminal winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871867.1">
        <property type="nucleotide sequence ID" value="XM_022015610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIK0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIK0"/>
    <dbReference type="GeneID" id="33557419"/>
    <dbReference type="InParanoid" id="A0A1Y1UIK0"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="397"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="544" mass="61815" checksum="AEA4662159C4350C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIV7</accession>
    <name>A0A1Y1UIV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_656152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871896.1">
        <property type="nucleotide sequence ID" value="XM_022018836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIV7"/>
    <dbReference type="GeneID" id="33560645"/>
    <dbReference type="InParanoid" id="A0A1Y1UIV7"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013095914" evidence="5">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="67"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="454" mass="49800" checksum="6868023546DDE269" modified="2017-08-30" version="1">MHQLFHHLLLATSLVAIASGNVIRGVNLGGWLLVEQWMTPSLFYDTTAADEWHLCNQLGKEACLGLLQDHWSTFYTRDDLVAIQAAGLNAVRIPIGYWAVDLLDYEPYVSGQFPYLIQAVNWAQELGLTVLIDLHGAPGSQNGQDNSGLIGPVLFATNSSNIDRSLNVIRNLTQEFSQSQYGGVVTSIELLNEPRLGNTFNMSQLKSFYSGGMSNMTSVSHGQMNMTIHDAFWGPQYWAGYDPSSSGESSIPTVIDTHQYYAFPPLGNLTHHAILQSICNISYLLKSTDLNLLPTVVGEWSLESGNPPNTSSSDQNDGDDTAKRTWLRLMFEAQLAAYEPNGPGQPSLGWYFWSWKQEWDIDTWSYRMGIGDGWIPSDVSNMSQRVYPLLSNGCVDAGFNYTAPPLSSGSSSGGGNGGGGYGGYPPYYYGSSPAKSAPFLLSFLLVMLTLYLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIY0</accession>
    <name>A0A1Y1UIY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_650094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871504.1">
        <property type="nucleotide sequence ID" value="XM_022018096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIY0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIY0"/>
    <dbReference type="GeneID" id="33559905"/>
    <dbReference type="InParanoid" id="A0A1Y1UIY0"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="561" mass="61674" checksum="CD52D0BF11284E9D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJA1</accession>
    <name>A0A1Y1UJA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_579243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871543.1">
        <property type="nucleotide sequence ID" value="XM_022013366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJA1"/>
    <dbReference type="FunCoup" id="A0A1Y1UJA1">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJA1"/>
    <dbReference type="GeneID" id="33555174"/>
    <dbReference type="InParanoid" id="A0A1Y1UJA1"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="189" mass="20997" checksum="C733D6B429FDEC76" modified="2017-08-30" version="1">MSFLFVSRFAAFYNRNFEKRPVPTLIVTNGVLNSIADAMAQSSTILASTGSVKEVVQQYDTKRTLRFCIFGMAMGPVIGGWMRLIERGIPLRKVGGNGIQLAKRVLADQAIMAPIGLVLFVGSMGIMEGKNTTQLQEKYQDVTALLANWKVWPLIQTINFKLMPLAYRVPFQSTCGIAWTLYLSLLNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJB4</accession>
    <name>A0A1Y1UJB4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_577895</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872082.1">
        <property type="nucleotide sequence ID" value="XM_022013283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJB4"/>
    <dbReference type="GeneID" id="33555091"/>
    <dbReference type="InParanoid" id="A0A1Y1UJB4"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="322" mass="35005" checksum="31A2D59EC9009193" modified="2017-08-30" version="1">MDYFDFKGTPTGTITVSPPGGTGGHHKGGHHGAPGPLPTDDFPSPIPKLLHATKAGHTTLWVVFAIFTIGLIGLWPMALRVEKRARFFHGVSAGVLTIAMVSYLAMATGLGTTFVPIHNHAADASVYKYFREVYFARYIDWLFTTPLLLLSLAVLAGLSPADTVLVICADVFMIVTGLLGGLVPARWATGERSRWTWFTVSCIGFLVIWYVLITGGLRASKHRPSKTRGLFVLLSIMTFILWAAYPVVFALTEGANMVSVNTEVIAYAVLDVSAKVGFTYMLLLVHTHGEDDTWTLPEWFVTHRHGHGSDGRGGYGAIGNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJC7</accession>
    <name>A0A1Y1UJC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_622730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871634.1">
        <property type="nucleotide sequence ID" value="XM_022015508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJC7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJC7"/>
    <dbReference type="GeneID" id="33557317"/>
    <dbReference type="InParanoid" id="A0A1Y1UJC7"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="199" mass="21555" checksum="2375175119B97D16" modified="2017-08-30" version="1">MSQPSAEEVEEFMLSCRYGEIDEVKMFTDKYGNAGVEAARDDRGNTALHMCSANGHIDILNLLLPLCSAALVSQPNDNGSPPLHWAIVNNHLNCVQALVELSPEKGGGLKLVKQTNSVGRDAFAEAVFAGEGREEVAGWLEGYLYREEGIPDEEMGDEDVKEEATDEMVADDDVQGTGVGPDAETQMVQDIQKVDLNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJF2</accession>
    <name>A0A1Y1UJF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_622545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871583.1">
        <property type="nucleotide sequence ID" value="XM_022015486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJF2"/>
    <dbReference type="FunCoup" id="A0A1Y1UJF2">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJF2"/>
    <dbReference type="GeneID" id="33557295"/>
    <dbReference type="InParanoid" id="A0A1Y1UJF2"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="697" mass="78488" checksum="176C3613B2AE4DF8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJQ1</accession>
    <name>A0A1Y1UJQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_620003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872134.1">
        <property type="nucleotide sequence ID" value="XM_022015241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJQ1"/>
    <dbReference type="GeneID" id="33557049"/>
    <dbReference type="InParanoid" id="A0A1Y1UJQ1"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="308"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="401" mass="41415" checksum="AB06C2CE7A96727F" modified="2017-08-30" version="1">MEPNWGGFYNYYPQDSSRAFDRPQQTSNANDATTSSHDEQSHRRHMNPGPFLPPPPPPGPLSHSSGSPHMNLPPFSHSFYSSYHPPSQSSPQSGGGGGPNLGGLSSSYGASSSSGFGGGNNGGGSSYHGGGGGGNGGGPSGHNNSAGMGTASPTTAPGLMGGGMSRGMPSNTRAPHSYSESPRLGHGGMNNYSSSPGLHHVSPTSPTTHLIPQSLFGGGGGGNTGPGGNTMNANSSGGFAGGPLRSGGMQGSIKRKDRKGGGGGGGSPSISGESWDESDKSGKPIIGEETEEQPWGMPQDQYKALNPRDKKQVRNRIGARRFRAKRKDYVSNLESSLRARDDEMNALKHQVDAYRTQINELRTRLGMPLLSPQISNSSSTPGLGLLVSQSGSDGWGDIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK02</accession>
    <name>A0A1Y1UK02_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872241.1">
        <property type="nucleotide sequence ID" value="XM_022018034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK02"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK02"/>
    <dbReference type="GeneID" id="33559843"/>
    <dbReference type="InParanoid" id="A0A1Y1UK02"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="148" mass="16337" checksum="722E8CBB449FD281" modified="2017-08-30" version="1">MTALMDFVPIHEHPFTLEEAILMEIDILAAEIARLQNSIKHLQSTQEEIQTFISEDPENDDDGELSKALRENEDVIASQTERITLIKVALLNKVGEGGIKHYGLELPTKSPPTAPAESAEARGNYHQEPSQTEAETTDNLEADGGLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK74</accession>
    <name>A0A1Y1UK74_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871512.1">
        <property type="nucleotide sequence ID" value="XM_022018097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK74"/>
    <dbReference type="GeneID" id="33559906"/>
    <dbReference type="InParanoid" id="A0A1Y1UK74"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="127" mass="13397" checksum="3DD7A1DED1F72E60" modified="2017-08-30" version="1">MVSSLEKRIMLTKLASKCTSPRSCRLCHGPLTLPNPNAPPTRAESIIGQVDCHPSCLPFACTGCVQKDRQSYGLCNIASSDSRCTLCSEEAEDGWNGRLTTTMSRNASPPASPTSSASSSDGGLGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKE6</accession>
    <name>A0A1Y1UKE6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872374.1">
        <property type="nucleotide sequence ID" value="XM_022018049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKE6"/>
    <dbReference type="GeneID" id="33559858"/>
    <dbReference type="InParanoid" id="A0A1Y1UKE6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="539" mass="58532" checksum="F212361EB33DD7D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL90</accession>
    <name>A0A1Y1UL90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_641191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872673.1">
        <property type="nucleotide sequence ID" value="XM_022017404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL90"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL90"/>
    <dbReference type="GeneID" id="33559213"/>
    <dbReference type="InParanoid" id="A0A1Y1UL90"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF10">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="585" mass="63086" checksum="11DC5F7EF5961FDF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULL5</accession>
    <name>A0A1Y1ULL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative iron ion homeostasis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_352071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872298.1">
        <property type="nucleotide sequence ID" value="XM_022012558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULL5"/>
    <dbReference type="FunCoup" id="A0A1Y1ULL5">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULL5"/>
    <dbReference type="GeneID" id="33554366"/>
    <dbReference type="InParanoid" id="A0A1Y1ULL5"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="278" mass="31032" checksum="D63834867ECB3EF9" modified="2017-08-30" version="1">MRSVIASSSRAIVRTLVTPVISPRAFSTGLPTRHFMPRHVHRSLLRPQPQALSQRRSMFIQTETTPNEASLKFIPGVPVTSSGTHEFLDLRSALPSPLATRLLSIDGLTGVFYGPDFVTCTKDDSFQWSLLKPEIFATLMEHFSSGAPLFRDGEDISGAEDTRILDTDSEVVGMIKELLETRVRPAIQEDGGDIEYKGFDEETGIVKLRLKGSCRGCSSSSVTLKNGIERMLQHYVPEVQSVEQVLDQEEQIALDEFAKFEARLEKKSKPDMSQYMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM18</accession>
    <name>A0A1Y1UM18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho GTPase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_576998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872954.1">
        <property type="nucleotide sequence ID" value="XM_022013231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM18"/>
    <dbReference type="FunCoup" id="A0A1Y1UM18">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM18"/>
    <dbReference type="GeneID" id="33555039"/>
    <dbReference type="InParanoid" id="A0A1Y1UM18"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="801"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1138"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130973" checksum="A87154186B950F3E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM40</accession>
    <name>A0A1Y1UM40_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_679610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872976.1">
        <property type="nucleotide sequence ID" value="XM_022019049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM40"/>
    <dbReference type="GeneID" id="33560858"/>
    <dbReference type="InParanoid" id="A0A1Y1UM40"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="254" mass="27781" checksum="8C266EAECC8BCA79" modified="2017-08-30" version="1">MNDVHLIHPTVRAPSPRSETQKGSVQTVDAGLQGDSIKHQLAALETRLLTSGHNHTEIFTAFAQFLAERISHGHSKPALEKAAELHQVTSLNHGGPGLASRSVHDQGSLSTVGELDNQGTPEEPLAHNLESVSSEQRVRQFTRIRAEAEVELEAIKTARASLNTAVDAQQDKSPVEGSSTEPNLQDLYVEPPPLMDIGDTTETLARSDDCHKPADRLFQWKSTRGNGYRSTCEDMLKTRPIRSTSVRDLPSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM59</accession>
    <name>A0A1Y1UM59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_679976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872137.1">
        <property type="nucleotide sequence ID" value="XM_022019060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM59"/>
    <dbReference type="FunCoup" id="A0A1Y1UM59">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM59"/>
    <dbReference type="GeneID" id="33560869"/>
    <dbReference type="InParanoid" id="A0A1Y1UM59"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="256" mass="29750" checksum="33DFB0711CCDEA34" modified="2017-08-30" version="1">MADYQAILDEEFEVLESIFPDELEKLGDRKVQILVEPEEASGSQLSLHLIVSYPSTYPDVIPDLSFESIDEETGELSEEEEEKLLESLRQVAEESIGMAMTFTIASAAREALAEVLKDRQRREKEEDDRRAAEYEEMEARKTRGTPVTTASFEAWRRKFLEELRQKRDKEESDRLKALPPKEREDFKRRKERPSGKQLFQSSQALATSDEALYEEGAQEVDMSKYTREEREKERRLEEEEAERARRGLVDGDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM65</accession>
    <name>A0A1Y1UM65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_649604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872147.1">
        <property type="nucleotide sequence ID" value="XM_022018017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM65"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM65"/>
    <dbReference type="GeneID" id="33559826"/>
    <dbReference type="InParanoid" id="A0A1Y1UM65"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="298" mass="32086" checksum="A1FA9B850F3E87CC" modified="2017-08-30" version="1">MSGKKNKGKGIMADGQHGQDGLADLKMDSSVDILASDPLPTVHVSKSNLGEMKNALDDAVKKHLTGMSFTPSIFNPTVHLSLGYTSVLLCLGSVLYSLRVEFEDSKPALWVGVVGYFTFQSILWAWKRWVERGEIFRGRRRRIVKRIETDHIQITTSTNFNAPQVPSITFSPHTRPSSPSLAPSSPISSPGSSPNNSSTLPPKSTTDSQQTFTPSSIPSSVGKTDCGPTYSVQLTLSTTSNSGKSLLRKSRVVAGRGVGEFIDTHGGIEEGEIGRWLNGLLIDAGLVGAEETEGLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM72</accession>
    <name>A0A1Y1UM72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_621521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872516.1">
        <property type="nucleotide sequence ID" value="XM_022015389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM72"/>
    <dbReference type="FunCoup" id="A0A1Y1UM72">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM72"/>
    <dbReference type="GeneID" id="33557198"/>
    <dbReference type="InParanoid" id="A0A1Y1UM72"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="282"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="426"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="587"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="654" mass="75421" checksum="88D4814E2D44A178" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM75</accession>
    <name>A0A1Y1UM75_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_313400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873013.1">
        <property type="nucleotide sequence ID" value="XM_022012462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM75"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM75"/>
    <dbReference type="GeneID" id="33554270"/>
    <dbReference type="InParanoid" id="A0A1Y1UM75"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1042" mass="111371" checksum="BB5089B1A5D43DA6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMS3</accession>
    <name>A0A1Y1UMS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">BD324DRAFT_649427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMS3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMS3"/>
    <dbReference type="InParanoid" id="A0A1Y1UMS3"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="245" mass="26865" checksum="7E712A75C87E4DC6" modified="2017-08-30" version="1">MTYPLSTTQPDPDVSNQAVNAPPREQLLSNLSLQSILLTQLFAIISNPPTQAPGTAQSHPVAGLYRAIDTATNDLGGIVKEVRIHQQAWARLERVKDQVKALDMDVRRVIGDLERGRVELEGMVNEGIKVREAIDRVSKDPLPVQPLLAHARSLARHSSAPVSSLLAPIDKAQYQPWPTETAMRAGILFREGGSMSGIGDVGIVGEERPQEAVQMMEEDYMQQEESRRPAPAVFSLDLNSDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMV5</accession>
    <name>A0A1Y1UMV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_577128</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873256.1">
        <property type="nucleotide sequence ID" value="XM_022013242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMV5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMV5"/>
    <dbReference type="GeneID" id="33555050"/>
    <dbReference type="InParanoid" id="A0A1Y1UMV5"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="119"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="699" mass="77135" checksum="74611409B4B81999" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNF6</accession>
    <name>A0A1Y1UNF6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_575719</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873383.1">
        <property type="nucleotide sequence ID" value="XM_022013140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNF6"/>
    <dbReference type="FunCoup" id="A0A1Y1UNF6">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNF6"/>
    <dbReference type="GeneID" id="33554948"/>
    <dbReference type="InParanoid" id="A0A1Y1UNF6"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX39598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="35529" checksum="168EEA38C63C0354" modified="2017-08-30" version="1">MGIQGLLPMLKEIQESGHIEHFRGKRLAVDAYVWLHKGAFGCAEALVKGQVNTKFVDYAMHRVRLLRHYGIEPYIVFDGGPLPAKKVTEVARAKSRAESLAKARSLESQGRGHQARDHYTKCLDITPELAFQLIKALRAEEVDYIVAPYEADAQLCYLEREGIVDGIITEDSDLLVFGCKQVIFKLDGQGHCVWINRERFGETSSFPMHGWTDVEFRRMTMLSGCDYLPSIQGMGLKTAHRMLRRCKTVEKTLATVRMEGSMDIPSTYLAQFAQAELAFMYQRVYCPRAQRIITLNELPEVGISEDDHKWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNJ2</accession>
    <name>A0A1Y1UNJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_576317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873406.1">
        <property type="nucleotide sequence ID" value="XM_022013183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNJ2"/>
    <dbReference type="FunCoup" id="A0A1Y1UNJ2">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNJ2"/>
    <dbReference type="GeneID" id="33554991"/>
    <dbReference type="InParanoid" id="A0A1Y1UNJ2"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="136" mass="15415" checksum="314700DFEF60DF8D" modified="2017-08-30" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNK6</accession>
    <name>A0A1Y1UNK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_614297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873384.1">
        <property type="nucleotide sequence ID" value="XM_022014578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNK6"/>
    <dbReference type="GeneID" id="33556386"/>
    <dbReference type="InParanoid" id="A0A1Y1UNK6"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="136" mass="14981" checksum="3B3CD26E75D21D92" modified="2017-08-30" version="1">MLASRVLRAKPAFTHTPMIKFLGQRSYDNAPHAPAPHPQAPKEVAENFQSFLAKLQSSSKGSDWPSSTPKGQSVEQSSKGQTPQDNDTTRGPLEKKSADFENFWDAPERLWMPKEVSEREIEAVMSGGATDIRSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP58</accession>
    <name>A0A1Y1UP58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oligopeptide transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_322097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873129.1">
        <property type="nucleotide sequence ID" value="XM_022012480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP58"/>
    <dbReference type="GeneID" id="33554288"/>
    <dbReference type="InParanoid" id="A0A1Y1UP58"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="839" mass="94834" checksum="6CFEE3E5380477AB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP64</accession>
    <name>A0A1Y1UP64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-glycan biosynthesis class S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_619292</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873200.1">
        <property type="nucleotide sequence ID" value="XM_022015161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP64"/>
    <dbReference type="FunCoup" id="A0A1Y1UP64">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP64"/>
    <dbReference type="GeneID" id="33556969"/>
    <dbReference type="InParanoid" id="A0A1Y1UP64"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="583"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="682" mass="75909" checksum="83145E67E55DAF10" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPB6</accession>
    <name>A0A1Y1UPB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_615349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873663.1">
        <property type="nucleotide sequence ID" value="XM_022014711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPB6"/>
    <dbReference type="FunCoup" id="A0A1Y1UPB6">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPB6"/>
    <dbReference type="GeneID" id="33556519"/>
    <dbReference type="InParanoid" id="A0A1Y1UPB6"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="25"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="589"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="887" mass="100374" checksum="2C5DD27B2A06F7E9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPJ1</accession>
    <name>A0A1Y1UPJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_615627</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873736.1">
        <property type="nucleotide sequence ID" value="XM_022014747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPJ1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPJ1"/>
    <dbReference type="GeneID" id="33556555"/>
    <dbReference type="InParanoid" id="A0A1Y1UPJ1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="274"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="42680" checksum="39817E3CCFCC39C7" modified="2017-08-30" version="1">MMGDEGLLIKREHEADTSTYRPEENKRRRKSNVRMQEEVIKQDIQLDESSGGAGKSGGLTECNGRAKDTLAELLSWREEIHADQVESVDQPVKSKGKRAAKAAEANVEKRDKRFRIKAPQATLQRAERVKAQRMFMLDRQKLDDLQEKFQVLGSTGNVYTVMIEAQPSCDCPDFQKGNAPCKHVIFVFLKVLKVPEDSSLWFQRSLLTGELRTIFSAAPLSPTDTVSVSLTVRNAYLKATGLPGAAGGQDIADGEDSEVDSAPIRKIISVGEDCPVCYEEMTEEDDRKKRLVYDDAPQGCGKALHKICFNTWANTRRDRGGVTCVWCRGVWPSAAGTQITSGSVGVQVTASGYLNMADIAGISRIRDTSTYHFPWRRTYHEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPN1</accession>
    <name>A0A1Y1UPN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_615964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873803.1">
        <property type="nucleotide sequence ID" value="XM_022014774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPN1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPN1"/>
    <dbReference type="GeneID" id="33556582"/>
    <dbReference type="InParanoid" id="A0A1Y1UPN1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="34519" checksum="D81A5646A8252CEF" modified="2017-08-30" version="1">MPATTYHGPINPHPGNGEASIIIFGYVPSLGLAIAGIVLWALVIAAQTWFTIVQKGYRTFHLLLLIGSLMELGGYASRAYAHFHPFLISTFISQYFLIVVAPVLFSAATYLSLTYVINAFPGSDSLLVVSRKVVLGFFVTVDVVCTVIQVLGSALIGTSESAAAQGNSSAVTPTQANDILLAGLAVQTFSFLCFLTVLSVASYRANNSKFTLTSGSLAERKRLRLFLWVIVFAADLILLRTTYRLAETAQGFFGTAATSEVLYGCLESLPIILALMTWSFLPPSKLAKPRREEKQEVQTGSTEEKKRGGRFERGESSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPS9</accession>
    <name>A0A1Y1UPS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_615928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873794.1">
        <property type="nucleotide sequence ID" value="XM_022014770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPS9"/>
    <dbReference type="GeneID" id="33556578"/>
    <dbReference type="InParanoid" id="A0A1Y1UPS9"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="350"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="623" mass="72087" checksum="C99CA864AB7306E7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPZ2</accession>
    <name>A0A1Y1UPZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_640869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873422.1">
        <property type="nucleotide sequence ID" value="XM_022017378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPZ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPZ2"/>
    <dbReference type="GeneID" id="33559187"/>
    <dbReference type="InParanoid" id="A0A1Y1UPZ2"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="480"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="673" mass="74899" checksum="FF8D5E1207DC3F80" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ04</accession>
    <name>A0A1Y1UQ04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_614468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873432.1">
        <property type="nucleotide sequence ID" value="XM_022014598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ04"/>
    <dbReference type="GeneID" id="33556406"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ04"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="201" mass="22638" checksum="51055D8BEE7C46BB" modified="2017-08-30" version="1">MLRLERGSLTNLNPKAWLIQAGNAFHGDVIRRTFQARAKIGTDDGFVWVIGQKEGDIQGALHALPPGYTFGQSKNHPEGIPSFKEQMDPELRKWKEDTYLPWVTDAFHRGTLKKNTSVKESLYLSVLGVDPSTQRNGYGRALVRTMQEEAASLGVPLTLGCGEEDTVRWYQRLGFEETLKETIQIRGENQTAHVLVWTPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ19</accession>
    <name>A0A1Y1UQ19_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynein associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_648760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873943.1">
        <property type="nucleotide sequence ID" value="XM_022017880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ19"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ19"/>
    <dbReference type="GeneID" id="33559689"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ19"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="77"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1168"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="279"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1006"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX40158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139986" checksum="0F0D4B9E7CD83A0A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQI6</accession>
    <name>A0A1Y1UQI6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873268.1">
        <property type="nucleotide sequence ID" value="XM_022017996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQI6"/>
    <dbReference type="GeneID" id="33559805"/>
    <dbReference type="InParanoid" id="A0A1Y1UQI6"/>
    <dbReference type="OrthoDB" id="2571862at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="514" mass="55365" checksum="181DECDF52F32B9E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQK3</accession>
    <name>A0A1Y1UQK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_576340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874037.1">
        <property type="nucleotide sequence ID" value="XM_022013184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQK3"/>
    <dbReference type="FunCoup" id="A0A1Y1UQK3">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQK3"/>
    <dbReference type="GeneID" id="33554992"/>
    <dbReference type="InParanoid" id="A0A1Y1UQK3"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="251"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX40252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="562" mass="63274" checksum="2ED806ED75C6AB82" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQK9</accession>
    <name>A0A1Y1UQK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_679349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874116.1">
        <property type="nucleotide sequence ID" value="XM_022019037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQK9"/>
    <dbReference type="FunCoup" id="A0A1Y1UQK9">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQK9"/>
    <dbReference type="GeneID" id="33560846"/>
    <dbReference type="InParanoid" id="A0A1Y1UQK9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36435" checksum="5496255719A4DB25" modified="2017-08-30" version="1">MLEMFDTKALGFFVPAPTWGIEDIPDLTGKVAIVTGANTGIGKQSAKHLLQSGATVYAAARSEEKCLNAIEDIKAETKRSDIHFLHLDLGDIAQSYSAGLEFAKSHDRLDMLINSAGVMTPPKGSRTKDGYDLQFGTNCIGHFAFSQPLLKLLRSTAKTAPANSVRIVWVSSAAHFLGSKEGIDFESITEVSRVSPFYHYSQRHVCEMLHTLSERSKLGSIHLANECANRLRDDGIISVSLRNISTDLQRNMWLVRTFMPLYSASLGCLTQLYAATSTDVTMADTGSYYVPWARKYHPSHPKANDPDSQRSTWEFCQAQLEKVVGPTVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR49</accession>
    <name>A0A1Y1UR49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_596077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874220.1">
        <property type="nucleotide sequence ID" value="XM_022013856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR49"/>
    <dbReference type="FunCoup" id="A0A1Y1UR49">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR49"/>
    <dbReference type="GeneID" id="33555664"/>
    <dbReference type="InParanoid" id="A0A1Y1UR49"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="338"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="422" mass="46246" checksum="CD753257EF706137" modified="2017-08-30" version="1">MLSRSLRRAAIFPAEITPRNALRQATRLISRRGIASTAARWQDLRKTPLYEFHVSQSAKMVPFAGFSMPLSYGDIGQVAAHNHVRTAAGIFDVSHMLQHRFTGDSAEAFLMSLCPTSLDALPPFTSSLSVLLNEQGGIIDDMMVTKQSSSEAYYVVTNAGRIKEDKELIREKLRDWNESHQSEPVRWETLDGWGLLALQGPKSAEVLQALIKDVDLTSLKFGKSVFAPVGHDKVKCHIARGGYTGEDGFEISIPPQHTVALTKEIASNPDVMMIGLGARDSLRLEAGMCLYGHDLNEAISPVEAGLTWTIGKERRSEEASPFPGKSRILSEIANGPSRRRVGLQVEGPPAREGSKIFDSTGTQEIGIVTSGIPSPTTGTNIAMGYVASGHHKKGTEVQVEVRKKLRPAFIRPMPFVPPKYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URA1</accession>
    <name>A0A1Y1URA1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874282.1">
        <property type="nucleotide sequence ID" value="XM_022017675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URA1"/>
    <dbReference type="GeneID" id="33559484"/>
    <dbReference type="InParanoid" id="A0A1Y1URA1"/>
    <dbReference type="OrthoDB" id="2573559at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="658" mass="69367" checksum="8A7EC180C60628A8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URI7</accession>
    <name>A0A1Y1URI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_15361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874357.1">
        <property type="nucleotide sequence ID" value="XM_022012033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URI7"/>
    <dbReference type="STRING" id="4999.A0A1Y1URI7"/>
    <dbReference type="GeneID" id="33553841"/>
    <dbReference type="InParanoid" id="A0A1Y1URI7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="456" mass="49333" checksum="A4E56852E32CE4CD" modified="2017-08-30" version="1">MTDAPYPFPPEPEATAESSSSSPSGEFDSGSKRRLSLRRGSNNGRDEIKKHRESPHLRRSSRTDTTQQRDSADVSGGVDDLSKEAIGSGQRHEDVDPEPVQGVTTNTSVHEPSHDSKRVRRRSKEDHSSSLSSPRPPASPPAASFSSFEPVKRSRKFSPSGQITEKHHFVAKRPPSTGLPVHRSTFDPGPTSHPSLSPHPTASKVAISESSSSHSFSRPPRSLTATSPSSSTSIDSTSHVFLSAPAPSSLTAISSDAGYHYPSSRPSHPHHPHLPTPISAGSRSGSASASASGAQQPRSSMTSGWIMSEREQANVNQIDRTDREEEDEDQGRSSRRRLELDVDVSRPRSRHHDQSMKTEDPESQSAISSSYSSSRYSRPSQQGLSTSAPSRFPSPPPSFSLSSGRPLVQPPAKTQAAFVGKLYAMLEDEEIIKTGLIHWSPDGTIFTCPNPTEFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URJ9</accession>
    <name>A0A1Y1URJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPX domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_10313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874268.1">
        <property type="nucleotide sequence ID" value="XM_022011913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URJ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1URJ9"/>
    <dbReference type="GeneID" id="33553721"/>
    <dbReference type="InParanoid" id="A0A1Y1URJ9"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="609" mass="67915" checksum="8A2A40EC601C9F91" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URM6</accession>
    <name>A0A1Y1URM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_256476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022012298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URM6"/>
    <dbReference type="GeneID" id="33554106"/>
    <dbReference type="InParanoid" id="A0A1Y1URM6"/>
    <dbReference type="OrthoDB" id="2592649at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="157" mass="16952" checksum="ABD691A2B7F0A6E9" modified="2017-08-30" version="1">MASMEDLVATMRGGLHVERGNDLQELQNKLAQTLNPVKAPYRPIPPTSLSPNTSTIPPAPASSWNDAFGSVSPSNSTTTQQNLPLDRNGTSPRSSGVRKDIGFSIPPPKSQSQGQPPSQNQANAQSNVIGSDHRSEEDDGFRDDAFRPLWQSDSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US52</accession>
    <name>A0A1Y1US52_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_22286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874488.1">
        <property type="nucleotide sequence ID" value="XM_022012217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US52"/>
    <dbReference type="FunCoup" id="A0A1Y1US52">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US52"/>
    <dbReference type="GeneID" id="33554025"/>
    <dbReference type="InParanoid" id="A0A1Y1US52"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="376" mass="41399" checksum="8DA4E531B1FD75E9" modified="2017-08-30" version="1">MLSNAFRPASQDIALVDPPPDSISRIKFSPTSNLLAVASWDNAVRLYQVDQQGQSMMQGKLSHNAPVLDVTWTENGSHLCAAGCDNMATLYDAQTGTPQQVAQHDAPIKCVEFVNAKGTNVLATAGWDNKLKYWDIRQGQTPAMTIDLGDRAYSMDATKELMVVATANRRLKIIYPDERPEMIFKDVESPLKWQTRVVSCFPTGHTYAVGSIEGRVAIQYPKEIDDKKNYSFKCHRYDIPSGSMPGTPAVFNTATSQNSQNVFAVNTITFHKVHGTFCTGGSDGSITFWDGIGRTKVKAFTLKELNNGDSDARPPQWGTPVVSTAFNHNQEIFAYALSYDWAKGHGGAPPPGQNPTKVMLHSVKPDEVRKKDKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI0</accession>
    <name>A0A1Y1USI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_31400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874659.1">
        <property type="nucleotide sequence ID" value="XM_022012463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI0"/>
    <dbReference type="FunCoup" id="A0A1Y1USI0">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USI0"/>
    <dbReference type="GeneID" id="33554271"/>
    <dbReference type="InParanoid" id="A0A1Y1USI0"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="3">
        <location>
            <begin position="320"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="569" mass="62865" checksum="87C1AAB42CD14FD7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USM4</accession>
    <name>A0A1Y1USM4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trehalose transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_265754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873990.1">
        <property type="nucleotide sequence ID" value="XM_022012323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USM4"/>
    <dbReference type="GeneID" id="33554131"/>
    <dbReference type="InParanoid" id="A0A1Y1USM4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="62808" checksum="2A068F508C36BA8C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT14</accession>
    <name>A0A1Y1UT14_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Multidrug resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_613418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874830.1">
        <property type="nucleotide sequence ID" value="XM_022014496.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UT14">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT14"/>
    <dbReference type="GeneID" id="33556304"/>
    <dbReference type="InParanoid" id="A0A1Y1UT14"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="881"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="145"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="491"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="837"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1161"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="47"/>
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    </feature>
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            <begin position="75"/>
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    </feature>
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            <begin position="91"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="106"/>
            <end position="116"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX41151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1408" mass="151835" checksum="941025CD1443F162" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTB1</accession>
    <name>A0A1Y1UTB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_644144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874536.1">
        <property type="nucleotide sequence ID" value="XM_022017585.1"/>
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    <dbReference type="GeneID" id="33559394"/>
    <dbReference type="InParanoid" id="A0A1Y1UTB1"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="616"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="795"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="862"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="930"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1227"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1335" mass="148495" checksum="ED29124858BE0E2B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTN2</accession>
    <name>A0A1Y1UTN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_612108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874465.1">
        <property type="nucleotide sequence ID" value="XM_022014353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTN2"/>
    <dbReference type="FunCoup" id="A0A1Y1UTN2">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTN2"/>
    <dbReference type="GeneID" id="33556161"/>
    <dbReference type="InParanoid" id="A0A1Y1UTN2"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="7">
        <location>
            <begin position="805"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1139"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1172" mass="128187" checksum="F93B82D06997DB1C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUJ9</accession>
    <name>A0A1Y1UUJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_614079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874986.1">
        <property type="nucleotide sequence ID" value="XM_022014558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUJ9"/>
    <dbReference type="FunCoup" id="A0A1Y1UUJ9">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUJ9"/>
    <dbReference type="GeneID" id="33556366"/>
    <dbReference type="InParanoid" id="A0A1Y1UUJ9"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="257" mass="27640" checksum="F6EC8C3F1FCC8934" modified="2017-08-30" version="1">MSSIGTGYDLSVSTYSPDGRLFQVEYAGKAVEAAGVAIGLRCSDGVVLGVERILHSKLLVKGANRRIQSLDDSIGLASAGLLADGVHLADRGRDEVWNFRETYNAPIPTQILADRLSMYVQAYTAYSSVRPFGVSSLVAGVDKTGPRLFCIEPSGVFYGYRGYAVGKGAVLARTELEKAVGKETEEGGVALTCREGVLEVARIIHLVHDDNKDKEFELEMTWISPESNMKHAVVPADLLAEADAKGKAALEEGMEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUL8</accession>
    <name>A0A1Y1UUL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein MRP51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_606809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874845.1">
        <property type="nucleotide sequence ID" value="XM_022014029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUL8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUL8"/>
    <dbReference type="GeneID" id="33555837"/>
    <dbReference type="InParanoid" id="A0A1Y1UUL8"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49644" checksum="5C0FFF4064DACB07" modified="2017-08-30" version="1">MSSSFPQLLRQSTFAAFDPSISRVYTSTPSSVHKYGDWGLKKPIFRKKGPGYIRVHNLDAGQLLGSDWRSAEQEARFIKAYGDGRTLWTDRDDHFANAPIESSLWAESGLAEPASNKKADLVSDVNNMTEAEFAKYLKKVKAYRNQYLDMKLGDLREETVSKLELPEQRTMVNLGTRGYLSNADITNFQVGLTANQLAKKQTKNIVSQPHNVYGMAYSKMPSSSATVNPLLYHKGRALDHPADDRYGARSGRSALNKNWIVAMGGVAATSNANRGRIANPRSEILREGTDWGRVNRDQGVAMFKITKAQISEPPTVINVERKDARNVRFTPGGTRKPVTPLNTFKFDLQVSPVGDEIPVEVMEYGSKKWVAGKEDSSLESDGDDLMLDSWKDDILGDRTARSGQSSFERFAAKRGDEARSDLSDLIQRALQKMKDRKANEGVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UVL6</accession>
    <name>A0A1Y1UVL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874954.1">
        <property type="nucleotide sequence ID" value="XM_022017794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UVL6"/>
    <dbReference type="GeneID" id="33559603"/>
    <dbReference type="InParanoid" id="A0A1Y1UVL6"/>
    <dbReference type="OrthoDB" id="2565171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX41275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27163" checksum="F35778749AF5717E" modified="2017-08-30" version="1">MAMSGSTRTSDSAQRTHLHSSVLSHLTNQLAVLKALRQRSKDQHRSQIFYRRIAEIIRLSKLVQGVAERIREDGDSASSRRDRNLLRKFVMTLIKAAQSVQQQIELRHFLPLQMALLGIYARLFILTAHIAAVLGISQNELIGVIDGNDVAARELLASAGDSTEVMDLATEADFGQKVSRTNAEIAVKSIDDQRVEPAKTAPPPERTISPSTENSALTKRAGETPMPKQKKKKRAKRDAMDEIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6J2</accession>
    <name>A0A1Y1U6J2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_584767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867959.1">
        <property type="nucleotide sequence ID" value="XM_022013705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6J2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6J2"/>
    <dbReference type="GeneID" id="33555513"/>
    <dbReference type="InParanoid" id="A0A1Y1U6J2"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="133" mass="14716" checksum="2F6C23EF4571468C" modified="2017-08-30" version="1">MPLSKSFRIATNTVRFARSVHSSPVARDHFLNANREVFEKRALDANSSKPLLVDFTASWCGPCKILGPMLQRLTTPDTPYDLMTVDVDENNALAAEYKVSAVPFVVGFKNGKPVDKFIGMLPEAKVKAFLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6N6</accession>
    <name>A0A1Y1U6N6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_210498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867972.1">
        <property type="nucleotide sequence ID" value="XM_022012186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6N6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6N6"/>
    <dbReference type="GeneID" id="33553994"/>
    <dbReference type="InParanoid" id="A0A1Y1U6N6"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="178" mass="19741" checksum="3B16D0A821A77010" modified="2017-08-30" version="1">MGSILESDLKDWELVFDTNFWGPLKLVPHMVDNKGAAFVFNSTQVFEHGFAICGAYSTSKAAVTALADTLRNEVKGYDLQPGSIKTPFLDKSPESKTSVPFLQPIVEWIHSARDKAPLDPVKGAGRILDILASGELLPERLPFGQQAFNMMIPRLEARLADFKRNRAWSVGLDYAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6R7</accession>
    <name>A0A1Y1U6R7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_595116</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868032.1">
        <property type="nucleotide sequence ID" value="XM_022013841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6R7"/>
    <dbReference type="FunCoup" id="A0A1Y1U6R7">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6R7"/>
    <dbReference type="GeneID" id="33555649"/>
    <dbReference type="InParanoid" id="A0A1Y1U6R7"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="409" mass="45332" checksum="0D78F185982A7EBA" modified="2017-08-30" version="1">MIKCAGCQEKEASRLECPKCKKLGIAGSFFCTQDCFKKYWNDHKVIHDIINIAAKAEEEKSATIPPNMRNYAFTGTIRPVYPLSPYREVPKHIQRPDYADDPRGVSACEMAERRTIQVCTPQEIEGIRKVCRLSRDVLDIIASHVRPGITTDELDRICHEECIKRDAYPSPLNYNRFPKSVCTSINEVICHGIPDQRPLVEGDIINLDVSLYHGGFHGDVNGTYPVGKVDEESAELMATTKRSMEAAIAICKPGVAYRDIGNKIEEIIKPKGYGIVRRYTGHGIHHLFHCLPNIAHYGGSKTPGKMEVGHVFTIEPMINLGTENLTHWKDDWTAVTLDGRRSAQFEETILITENGAEILTRYSKNKKKKKKTAGGQAANGVADGDDTPEGAATPTAAQAAQGVESLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Y7</accession>
    <name>A0A1Y1U6Y7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_653829</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868077.1">
        <property type="nucleotide sequence ID" value="XM_022018714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Y7"/>
    <dbReference type="FunCoup" id="A0A1Y1U6Y7">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6Y7"/>
    <dbReference type="GeneID" id="33560523"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Y7"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="165"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="610" mass="65557" checksum="EB698E0F49B52CC4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6Z9</accession>
    <name>A0A1Y1U6Z9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_585251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867635.1">
        <property type="nucleotide sequence ID" value="XM_022013731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6Z9"/>
    <dbReference type="FunCoup" id="A0A1Y1U6Z9">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6Z9"/>
    <dbReference type="GeneID" id="33555539"/>
    <dbReference type="InParanoid" id="A0A1Y1U6Z9"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="253" mass="27327" checksum="B14520BF383299EF" modified="2017-08-30" version="1">MASSRLEILNDGGLRHDARRPYELRSLSLELSTHPNADGSSTVSQGLTTVSASVFGPREPKQRAGSVHDKASVVVEVGVAPWAGAREVRRTRGDKRLLEIAAAIRQTFEPVIMTHLYPRSEIAVHIQVISADGGILPTAINATTLALVDAGISLIDYVTSLSLGLHLTQPLLDLSAPEEADLPTLVVAALPSGKVTLAQMETRLHVDRFEEMLTLGVEGCGVLKTEMDRVVKDRTTRVVERMDKVIQGRITGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U737</accession>
    <name>A0A1Y1U737_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_610692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000025">
        <property type="protein sequence ID" value="ORX33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867685.1">
        <property type="nucleotide sequence ID" value="XM_022014213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U737"/>
    <dbReference type="GeneID" id="33556021"/>
    <dbReference type="InParanoid" id="A0A1Y1U737"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="25037" checksum="9F1D5F5BB3E003B3" modified="2017-08-30" version="1">MWSSLIRCYRKDLVLLRPSSSSSSSLRYHSRIPTCHLALALSLLDLEMSGPNKLLEVRLMTRNTKESSAGASKSREGSVLSNDPKPARKKQRTAVKSKVDNIRAVVERNPDNYRKLEPKDACSTCGDRYECHIFVPATSSKISCVGCGGQASCSLQTNATRGVIIGLSHFQKALTALEALEKELEEAKDDDDDGDKDERMDTDDLQMITEMIKNYKAWLKAYTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U819</accession>
    <name>A0A1Y1U819_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_636950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868459.1">
        <property type="nucleotide sequence ID" value="XM_022016960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U819"/>
    <dbReference type="FunCoup" id="A0A1Y1U819">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U819"/>
    <dbReference type="GeneID" id="33558769"/>
    <dbReference type="InParanoid" id="A0A1Y1U819"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="256" mass="28339" checksum="F242BAD9DF5C0524" modified="2017-08-30" version="1">MASTSNHISITSPEQFKSVLSEDLNRVSCLNFWAPWAEPCKDFNKEFENAAGKFPKTLFLSIEAEALPDIAETFDIEAVPSFLLLRGHTLLARHSGADTTLLHQLLSQHSGASPSQPLSTSDAKPAPPPAIPSVDSAPSKPRTEEEITARCKELMNKHKVVLFMKGNPSSPKCGFSRQTVGILREKGVEFAWFDILSDEDVRQGLKKLNDWPTFPQIILNGELVGGLDIFREMVESGEWDELYNGIEEEAEGEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8C6</accession>
    <name>A0A1Y1U8C6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rpp14/Pop5 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_653530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868540.1">
        <property type="nucleotide sequence ID" value="XM_022018667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8C6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8C6"/>
    <dbReference type="GeneID" id="33560476"/>
    <dbReference type="InParanoid" id="A0A1Y1U8C6"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="220" mass="24611" checksum="DF2281A0F0DF235C" modified="2017-08-30" version="1">MVRFKNRHILVEFLQPSTLSPTFNGSASKPKAQQFSGHSESPQGQLVNEGSDDEDEVNQALLQPSLPFMLPLPSVDGTKPRLHLGDEGGSVIYRAIKGSIQEVYGDEGWGRVASSFKVVYHSPLTTLTMLRIARQHYRLLWSAITFLTSVQGQDVLPRVVAVSGTIKKVQNTAIVYHRRVTARMLAVALEQEAGLVRSERERQLEAAWNNERKMIEMLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8H9</accession>
    <name>A0A1Y1U8H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_638839</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868143.1">
        <property type="nucleotide sequence ID" value="XM_022017164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8H9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8H9">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8H9"/>
    <dbReference type="GeneID" id="33558973"/>
    <dbReference type="InParanoid" id="A0A1Y1U8H9"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="328"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX33844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="730" mass="80573" checksum="16BC9C0EF04683F1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8J5</accession>
    <name>A0A1Y1U8J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">BD324DRAFT_635454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8J5"/>
    <dbReference type="FunCoup" id="A0A1Y1U8J5">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8J5"/>
    <dbReference type="InParanoid" id="A0A1Y1U8J5"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="347" mass="37554" checksum="81BFAADC4E0DE251" modified="2017-08-30" version="1">MSLDIDWQLLLSPDCSLAEKLIDILNDHLISASRPSFIGPIQVTNFAFGSAGPDLEIRDIRDVWRAFEEADDAGDQDQASLHRKTPPVSQLDDEAYDIISANDARDYFSEDDGTGLDDTSIYSGLASPRQSVGAVGIGIGSSALHFGMGRDYASAIMSSLPAQQNPSLFSQPHLRPRRGPRGLSVPSMVQHAVPPSSGNSPSKRSGGTSASPKSPLPSVQLHFRLSHRSNLTLTLLTSLSINYPAPSFMSLPLRLTVTGLELNADIVLAYSSDRNRVYVTLVDEDEAAINLPLGERLLPSLSIESEIGHTDAHVLRNVGKVEKFIADVIRKTLVEELAFPSFQTIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8M6</accession>
    <name>A0A1Y1U8M6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868182.1">
        <property type="nucleotide sequence ID" value="XM_022018675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8M6"/>
    <dbReference type="GeneID" id="33560484"/>
    <dbReference type="InParanoid" id="A0A1Y1U8M6"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="87439" checksum="9D7BB1B27EA96765" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8P2</accession>
    <name>A0A1Y1U8P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_665268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868202.1">
        <property type="nucleotide sequence ID" value="XM_022018910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8P2"/>
    <dbReference type="FunCoup" id="A0A1Y1U8P2">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8P2"/>
    <dbReference type="GeneID" id="33560719"/>
    <dbReference type="InParanoid" id="A0A1Y1U8P2"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="712"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1041" mass="115953" checksum="DA2D0816BFEF6CD5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8U7</accession>
    <name>A0A1Y1U8U7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_278263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867862.1">
        <property type="nucleotide sequence ID" value="XM_022012362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8U7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8U7"/>
    <dbReference type="GeneID" id="33554170"/>
    <dbReference type="InParanoid" id="A0A1Y1U8U7"/>
    <dbReference type="OrthoDB" id="2596880at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17759" checksum="20118A43CBD8D200" modified="2017-08-30" version="1" fragment="single">ALASGIPCLASAFIEDAIERDVDWRAYLISPGPSKIFNHRCSQLVDPNWGGADWSSAIARSLRQPFKGMEFLFLVPPGDSSILSTVRELVPFCLSAMGASNLKSIVSTSTIVNLSSYDIVLIESRCPGQIIPELWKSSGKLCNFGWLKQCIISGAKLPAEVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8V6</accession>
    <name>A0A1Y1U8V6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_584077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868205.1">
        <property type="nucleotide sequence ID" value="XM_022013654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8V6"/>
    <dbReference type="FunCoup" id="A0A1Y1U8V6">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8V6"/>
    <dbReference type="GeneID" id="33555462"/>
    <dbReference type="InParanoid" id="A0A1Y1U8V6"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="14"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="390"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="694"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115378" checksum="D32E3038D51A6A22" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U968</accession>
    <name>A0A1Y1U968_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868846.1">
        <property type="nucleotide sequence ID" value="XM_022016903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U968"/>
    <dbReference type="FunCoup" id="A0A1Y1U968">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U968"/>
    <dbReference type="GeneID" id="33558712"/>
    <dbReference type="InParanoid" id="A0A1Y1U968"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="354" mass="38397" checksum="A6C62263CE18213A" modified="2017-08-30" version="1">MSTPIRGLPVPFRDSPAPAYRREPLRVACVQFDVKRGEVKRNAESVEAMTSRLQPDSLDLLVLPEMCLSGYIFNSATAILPYLEQPRIGPTSLLARSLARRLRCHVVAGYPEALVEESGEAPTASSSSSLLLDSSAGVEETGPKAMKALEGEGEGVGFNSAIVVGPEGEIVGNYRKTFRFDTDKCWARAGSGFMHFDLPEPLGRTAIGICMDMNPKDFIAPWDAFELGSYVRESGADTLVVPMNWLQAPVEPPNQGLEMDPTAPDESSLNYWAARLQPLHDPTPGYVSPSPSSAMDPQGGKQVTFVACNRVGVEDGKRYVGTSCVMTLSSDPRRIELVEVCNMTEERVLVATVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U995</accession>
    <name>A0A1Y1U995_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868845.1">
        <property type="nucleotide sequence ID" value="XM_022016902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U995"/>
    <dbReference type="GeneID" id="33558711"/>
    <dbReference type="InParanoid" id="A0A1Y1U995"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="21350" checksum="3A60BD29D2392690" modified="2017-08-30" version="1">MSHKAPIKLESDRLVISRFLPTEEHAEFLVKLYNTPEFIAGEGNTGIDTTEKGLKALHSMSDRFDKYGHGVYVVSLKDTSTLVGSVSLMIGDYRAPDIGFALLTEYTKKGYATEAAKRVMQHAKEDLGYDGVFGFASPTNEHSRKALERLGMEYRGTFSLEAFGNQDSVVYTMQGMGELEQYGIKGDRKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9F1</accession>
    <name>A0A1Y1U9F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_583889</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868414.1">
        <property type="nucleotide sequence ID" value="XM_022013644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9F1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9F1"/>
    <dbReference type="GeneID" id="33555452"/>
    <dbReference type="InParanoid" id="A0A1Y1U9F1"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="57"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="573" mass="62884" checksum="3458316F48F5AEDF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9G9</accession>
    <name>A0A1Y1U9G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_637034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868472.1">
        <property type="nucleotide sequence ID" value="XM_022016964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9G9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9G9"/>
    <dbReference type="GeneID" id="33558773"/>
    <dbReference type="InParanoid" id="A0A1Y1U9G9"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="461" mass="51219" checksum="798A7481911D5240" modified="2017-08-30" version="1">MKWAVQTVKIGFPARITAPICSSSLARTLYTSRTNMQAEEDEEMNMNAVGSSSKSDSRDPGFMAYLPDEPGMSKNAMKRAAKQAFREAHRDEWKASVKAKKKEKKAALMEQLEAGTLDEEGLASLERQRESRRIKRKLLAGTGPDKEVWKGGLVVDLGFDNLMAEAEVKSLASQLSFLYATNRRAARPFSAILHTSFSETASPVLWSIMKERGWQSWDQCYWWHEGMADLAKTFGLSPKPKRKTPKSPSRSRSSSPRSPEVVSKAESSTATTGSSSHLDHEMGASLPTEQSEKPHSIEQTNGTPTVMQEDDTRTELPPSLSKDTHKLVYLSADASEELITLSEDEVYILGGLVDKNRYKLLCEDKAKSLGIRTARLPIGRYIADLPTRKVLTVNQTFEILVKYLELNNWAHAFAAVIPQRKFAAVSKKTLLRQRSKVASEPANLGDDASEVQLQEGEHDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9I8</accession>
    <name>A0A1Y1U9I8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferritin-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_583841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868492.1">
        <property type="nucleotide sequence ID" value="XM_022013640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9I8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9I8"/>
    <dbReference type="GeneID" id="33555448"/>
    <dbReference type="InParanoid" id="A0A1Y1U9I8"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="270" mass="28278" checksum="D4DC93AA13603765" modified="2017-08-30" version="1" fragment="single">ALIPVSSDILQYALTLENLENAFYSMGLAKFAQSDFENAGYPDWVRNRIVQIGGHEAQHVALLSGALGSAATQPCTYNFDAAMADVNAFIGYATLIENVGVSAYLGAASSITEPAYVTVAGSILTTEARHQGWLSSSVSKNQPWSGPEDTPLDFDEVYTIAAEFISSCPSTNPTLPVQAFPALTIGTDGTITTTASTANTYVQLVSGLDSNVFPVVNGKVQGLPQPQGISYAVLTTSSTNSGVSDSNIVAGPMILNNPFTSKVPNPAPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9K3</accession>
    <name>A0A1Y1U9K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_638536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868074.1">
        <property type="nucleotide sequence ID" value="XM_022017125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9K3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9K3"/>
    <dbReference type="GeneID" id="33558934"/>
    <dbReference type="InParanoid" id="A0A1Y1U9K3"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="305" mass="33459" checksum="E4C0F9ADFCFFEF8C" modified="2017-08-30" version="1">MKLLLTGASGSVGSHTLKYLLARSHDITAVDIVAIPIPTLSSTSATDRPPGQLTTVTCDLADWKAVEELFASQTVPFDGVIHFGAIPNPLYHDPRIVHNVNVTSSYNVLQTAASHGVKRIVQASSVNAIGLSYTPEGHKRVDTFPITEEEPITAEDAYAISKAACELQASALCRFYPDLRIASLRFHMCKPNYAESIAHSRVQDLFAWTSMASCASAALLSITSEGWHGHEVFNITAPEIVFQGLPDDMTAGPSALEAIETHWGGKYRVINKEWWADHPRRSVFDSTKAEKMLGWDHDKADEQCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA58</accession>
    <name>A0A1Y1UA58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_653662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868253.1">
        <property type="nucleotide sequence ID" value="XM_022018688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA58"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA58"/>
    <dbReference type="GeneID" id="33560497"/>
    <dbReference type="InParanoid" id="A0A1Y1UA58"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="881"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="923" mass="102392" checksum="31B61218391C81CF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA91</accession>
    <name>A0A1Y1UA91_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Histone deacetylase</fullName>
            <ecNumber evidence="1 4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_633286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="1 4"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869148.1">
        <property type="nucleotide sequence ID" value="XM_022016609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA91"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA91"/>
    <dbReference type="GeneID" id="33558418"/>
    <dbReference type="InParanoid" id="A0A1Y1UA91"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF2">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="9">
        <location>
            <begin position="102"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="466" mass="51682" checksum="1719A1415A483961" modified="2017-08-30" version="1">MTSVVEPFTPTPTASSSNPRRVAYFYDPDVGNYVYYLGHPMKPHRIRMAHNLIVNYGLCDDIDETGESEGSRSVNDPIVQEYAEGDGERAKTERLTGSRGKSMQVFRPRRADRGDMTKFHSDEYIELLEKVTPETAEYLTGGGVRCLIGEDCPAFEGLFEFCSISAGGTIAAAETLNSGAADITINWAGGLHHAKKTEASGFCYVNDIVLGILELLRIHPRVLYIDVDVHHGDGVEEAFYTTDRVMTASFHRFGEFFPGTGDVRDIGMKRGKGYSINVPLRDGIRDDSFHSIFKPIINSIIEHYQPGAIVLQMGADSLAGDKLGGFNLTLQGHAECARFVKAFGLPVMMLGGGGYTTKNVARAWTYETAVMCGKELDENLPYNQYMEYYGPRYKLEVLSNNTDDHNHPEYLDAIKRSVLHNLKNLPHAPSAGMQRAPQPLGKELGLKNGEALDPEDEVEIRLRSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAJ0</accession>
    <name>A0A1Y1UAJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_643468</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868790.1">
        <property type="nucleotide sequence ID" value="XM_022017549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAJ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UAJ0">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAJ0"/>
    <dbReference type="GeneID" id="33559358"/>
    <dbReference type="InParanoid" id="A0A1Y1UAJ0"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="223" mass="24761" checksum="007D47B71B92CF8E" modified="2017-08-30" version="1">MSQSSLDYPEMKELFDRNAAWSAQVWKKDPGFFPRHFPGQRPEIMWIGCSDARVPETTIMGCHPGDIFVQRNVANTYSPADDSLNAVLMIALQNFKVKHIVITGHTNCVGCNQALNMSRLPSVPPTTALQRYIQPVAALARSLTGENGLPSLDLLVEENVCQQVKNIEASDVIRNDWKRRGTDGVVIHGWVYHLENGTIRDLNVSVGPPGHVAGKRTTNGVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAP3</accession>
    <name>A0A1Y1UAP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain of DNA photolyase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_161214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868840.1">
        <property type="nucleotide sequence ID" value="XM_022012059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAP3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAP3"/>
    <dbReference type="GeneID" id="33553867"/>
    <dbReference type="InParanoid" id="A0A1Y1UAP3"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="326"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="445"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="622" mass="71135" checksum="078059514AB52B08" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBE1</accession>
    <name>A0A1Y1UBE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_583336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868658.1">
        <property type="nucleotide sequence ID" value="XM_022013616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBE1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBE1"/>
    <dbReference type="GeneID" id="33555424"/>
    <dbReference type="InParanoid" id="A0A1Y1UBE1"/>
    <dbReference type="OrthoDB" id="5314275at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="342" mass="38404" checksum="F40D5A6B2BD0E912" modified="2017-08-30" version="1">MPFGLPFIARPGQEGFDQYGRMIPPELPEGWDGWGRPLVGANAQPGGAQPPNIPPAGGVQPQPQGAGEAQPGFAPTNTRDAPFTVTQSTSSSTGTGRPDQPSCFDRPPAPADSYFRYADFEPFSLPASSLNHIWELHLSREFVGHDVSEEDWEKFVNDLAREALQNAPHNWARGGRNEGTLGRGPAPVLSDAVHSLLASWAVAFFAPRGIRVYAAQDGKRVIPLPIDPSSTKRGYSRPDEWSDEDGLSDEEDESDWAEEESRARRDDAYLPRREREVRRDERMRARRRDRRRRRDMEVESRRSSRRKDSGTWEVHFIAATPTIWVAGARPRTYGEPVVRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBN1</accession>
    <name>A0A1Y1UBN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Poly polymerase and DNA-ligase Zn-finger region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_632683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869592.1">
        <property type="nucleotide sequence ID" value="XM_022016542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBN1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBN1"/>
    <dbReference type="GeneID" id="33558351"/>
    <dbReference type="InParanoid" id="A0A1Y1UBN1"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="79" mass="8993" checksum="E9986E7C9C49F7B6" modified="2017-08-30" version="1">MPAYRLEVSSSNRAACNGKLPCKGNKIMKGELRLGTWVQIRDNGSFKWRHWGCVTEAQIQNLQKDFPNPDDVDGFEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC09</accession>
    <name>A0A1Y1UC09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_61801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869745.1">
        <property type="nucleotide sequence ID" value="XM_022014981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC09"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC09"/>
    <dbReference type="GeneID" id="33556789"/>
    <dbReference type="InParanoid" id="A0A1Y1UC09"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="168" mass="18472" checksum="FB54E4A68F9050C6" modified="2017-08-30" version="1">MQTALLDGSPCGYGGHCYNAECQTGSWQSVAGSWYRENLQISIPVTVVVGLIVLAILFAIIRCMLRSCSRRRSPQPLPPQRASMRQSVYAPTSGPFSSQEPLAPTRHSGHFPPPPQHPSQWQRPPSNHYGISQPPPSSPPQRYSGQSTWVDPSSYNGPHYGVNEAYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCW1</accession>
    <name>A0A1Y1UCW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_632507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869546.1">
        <property type="nucleotide sequence ID" value="XM_022016525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCW1"/>
    <dbReference type="FunCoup" id="A0A1Y1UCW1">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCW1"/>
    <dbReference type="GeneID" id="33558334"/>
    <dbReference type="InParanoid" id="A0A1Y1UCW1"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000100">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="341"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="527"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="753"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117140" checksum="E13C5BB587B78843" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCX3</accession>
    <name>A0A1Y1UCX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_629258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869981.1">
        <property type="nucleotide sequence ID" value="XM_022016188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCX3"/>
    <dbReference type="FunCoup" id="A0A1Y1UCX3">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCX3"/>
    <dbReference type="GeneID" id="33557997"/>
    <dbReference type="InParanoid" id="A0A1Y1UCX3"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="239"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="512"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="811" mass="89309" checksum="82F48BA4A0CE3EB0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCY1</accession>
    <name>A0A1Y1UCY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_682021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869991.1">
        <property type="nucleotide sequence ID" value="XM_022019135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCY1"/>
    <dbReference type="GeneID" id="33560944"/>
    <dbReference type="InParanoid" id="A0A1Y1UCY1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="216" mass="24157" checksum="CDB679F8AF88F08B" modified="2017-08-30" version="1">MTSLNDTHFQITVTAPTDDAKALFQRWKTPSLRGESLNDWRRVTTDDLGGDEPSDSELATTFRVYRHEFVRNEGGPKPCEDIPTLCVDFSDDATISKKDLEKLIDLAAKAICKSASLLEGLRDLQRQRDALAHPPLEAFHQLELSTRYLQKLLKSRASWGAARDQADSLLSLTHVSSLHGLTMASIKHAECLITNAGLTPTEEWISWTTNAKAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD24</accession>
    <name>A0A1Y1UD24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870080.1">
        <property type="nucleotide sequence ID" value="XM_022016238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD24"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD24"/>
    <dbReference type="GeneID" id="33558047"/>
    <dbReference type="InParanoid" id="A0A1Y1UD24"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="86942" checksum="685414B1D89DA730" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD50</accession>
    <name>A0A1Y1UD50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NRDE protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869636.1">
        <property type="nucleotide sequence ID" value="XM_022016569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD50"/>
    <dbReference type="GeneID" id="33558378"/>
    <dbReference type="InParanoid" id="A0A1Y1UD50"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="41234" checksum="9736DF12CEDA07A4" modified="2017-08-30" version="1">MCIVFWTLSHPGYKLILASNRDEYLARPALPAHWHTFGPIEEDQEAIRAESSKASTGGKGSGDQHADEPWIMCGRDMGSPEAGTWLGMTKDLRIGVLTSIRQGFKRRLFNPPSRGALVKDFLKRKDYSTSVHDHLASLRGTVEDYDGFNLLLFRLHPPSIDALDPDPQNEASEQPSSASAKSQASWGRPEVGYLSNHPSQTLMDIMSPTRVPTPVARDRSETLSTPLKLKGTKVGMCFGLSNSSISQPWPKVSRGEAEMSQTLREWSERKEGEEELIKRMQDLLSRSVPLTSLANVKECTCLHPVKLGTNPDEPLDTGLDGRWYGTRVSTVILVKNTGEVTFVEKSIFYQDENGDAVEGKDERVFRWSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDY0</accession>
    <name>A0A1Y1UDY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_603088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869880.1">
        <property type="nucleotide sequence ID" value="XM_022013957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDY0"/>
    <dbReference type="FunCoup" id="A0A1Y1UDY0">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDY0"/>
    <dbReference type="GeneID" id="33555765"/>
    <dbReference type="InParanoid" id="A0A1Y1UDY0"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18445" checksum="F0EFC933DBD28506" modified="2017-08-30" version="1">MSLLPPEDEQDDIEVAWEDQQRISSFSKLNNRLTDIQDQLKLKQVSISQSTLPLGFQSRGFRAENSPPQEEKEYYDDLSTEFMLADSSSGPFLYRIGEAFFYLPLKDAKKQLKGDLSRYNREISDLNDRAEECQKGMKELKVMLYAKFGKQINLETNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDY1</accession>
    <name>A0A1Y1UDY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870344.1">
        <property type="nucleotide sequence ID" value="XM_022016074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDY1"/>
    <dbReference type="GeneID" id="33557883"/>
    <dbReference type="InParanoid" id="A0A1Y1UDY1"/>
    <dbReference type="OrthoDB" id="3426336at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20302">
        <property type="entry name" value="cupin_DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="176" mass="20058" checksum="3C01B35776ED7C28" modified="2017-08-30" version="1">MTRPTDISAVPYSGPPLHGVPDDLVVHGVLDIDNCDERLWVPQTKDVWFRPLLFSVSQGYFVNLLRVRKSGILSRHRHTGPVHATVLRGRWHYLEHDWWAEEGGYAFEPPGDIHTLEVPEGVEEMVTLFHVTGAYIYVDPKGNAQAIEDVFSKIELAKEHFEKVGLGADYVNRFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEB9</accession>
    <name>A0A1Y1UEB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_628713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870502.1">
        <property type="nucleotide sequence ID" value="XM_022016138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEB9"/>
    <dbReference type="FunCoup" id="A0A1Y1UEB9">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEB9"/>
    <dbReference type="GeneID" id="33557947"/>
    <dbReference type="InParanoid" id="A0A1Y1UEB9"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="97" mass="11036" checksum="EDDD7BCF2E359261" modified="2017-08-30" version="1">MPQQVQDIKRFLEIARRKDATSARIKKTTLQPSKQTSASQKVKNARSAPTVTKFKIRCSRYLYTLVLHDAEKAEKLKQSLPPGLKVEEISTKAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEV3</accession>
    <name>A0A1Y1UEV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_630043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870196.1">
        <property type="nucleotide sequence ID" value="XM_022016286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEV3"/>
    <dbReference type="FunCoup" id="A0A1Y1UEV3">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEV3"/>
    <dbReference type="GeneID" id="33558095"/>
    <dbReference type="InParanoid" id="A0A1Y1UEV3"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="292"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="46619" checksum="CD465184BF04343E" modified="2017-08-30" version="1">MVDASDAGPSTSYTAFRKTEKHFKNRSSQSRLPTLYACEASRAALDVSRPDRQEDDPVWQASWWGAEQQNVRRRFQRDKGKRPELSEVPREVRCGSKTGYVVSEGCILLPGYLDNEAQLDLLEAALSQYTLPPNPLSISTHYDLPPNLFEMYANESKELIPTLAPCAETPESTGKEKPAERWIGRKTVDTPAGHVVGYEEILSKNRQWTADPPSEKLGSKTAGELMKEMRWANLGWVYQWSVKSYDFRPDSPITFPPNLSTLCVEVVKSVPWDHVLSADSNVGHKAWVNDYVPDTGIVNFYQTNDTLMAHVDRAELDPSRPLVSVSLGHACVFLLGTSSRDDQPLPIILRSGDVLVMSGTGRQNYHGVPRIMEGTLPSHFEPSEKDSVALSAAKRWIHGGRININARQVFPPGFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF08</accession>
    <name>A0A1Y1UF08_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_626358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870638.1">
        <property type="nucleotide sequence ID" value="XM_022015885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF08"/>
    <dbReference type="FunCoup" id="A0A1Y1UF08">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF08"/>
    <dbReference type="GeneID" id="33557694"/>
    <dbReference type="InParanoid" id="A0A1Y1UF08"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="139"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="245"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="492" mass="53405" checksum="2BC64B385561D551" modified="2017-08-30" version="1">MSSRSASAGHCFYSPSCTATIAFGIAYRRQPFPSTGKSKFHSKCLSIGFCCHRTFSYFTVSPTASTMVDSTNKGKRKVSPLPKLNGRLLCLGIEGSANKFGCGVIAHSPAPSAEPEAGEGSSSTSAHARHKNPATIVTVLSNVRHTYITPPGEGFLPSDTARHHREWAIKVISEAVRKAGIRISDLDCIAYTKGPGMGTPLQVGSLVARTLSLLHGIPLIGVNHCVGHIEMGRQITSSHNPVVLYVSGGNTQVIAYSQQRYRIFGETLDIAIGNCLDRFARIIRLRNDPSPGYNIELEARKGRRFIPLPFGTKGMDVTLAGLLTAIEQLTKDKRYRSWDSRASRAQGRGSALPPGEALVVEEDQDNHIANGQEVATEEDVITPQDLCFSLQETTFAMLVEITERAMAHVGAKDVLIVGGVGSNMRLQEMMGIMASERNGRVFATDESFCIDNGIMIAQAGLLAFRMGQTTPIEKATITQRFRTDQVHVSWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF32</accession>
    <name>A0A1Y1UF32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_460209</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870739.1">
        <property type="nucleotide sequence ID" value="XM_022012848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF32"/>
    <dbReference type="FunCoup" id="A0A1Y1UF32">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF32"/>
    <dbReference type="GeneID" id="33554656"/>
    <dbReference type="InParanoid" id="A0A1Y1UF32"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010992774" evidence="5">
        <location>
            <begin position="19"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="130"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="475" mass="53788" checksum="5AFA15476BE7DDDA" modified="2017-08-30" version="1">MRLGSNTVLMSMATLVLGARRDFPHHRVLSRQAAGVTGQSIIPDLLEGLEKNPALEVGIGINVNISADLDLDLGGFQYGSDKIRGVNLGGWLVLEKWLMPELFNETGNASIIDEWTWGEYQPRDQAESLMKQHWETWITEDDFRQIAALGLTHVRIPIGYWAFQVGPGEPYITGQQTYLDKGIEWARENGIKVLIDLHGVPGSQNGNDHSGRAGPIDWYNNATNVNRTLEVVRQIAQKYTLPPYSDVVTMFELINEPSVWISPLFATVLKQYYLDAYEIVRRPFGEFGPTTDIIVLLQDGFQPMTWWGDFMTPNYNGGDYERVWMDNHYYQAFNPSYGLLDAAGHINTTCNEAGVNFAQAQLPIVDGEWSMGLWGCLANDGVAQPNVGTCNDADPNFGSGYVRFNRAYWDVQTQIYEQVGNGQGWFYWTWKNHIDSPEWGYQLAVQDGWFPQDVTDHVHTRTELCHIVVIRDEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFD3</accession>
    <name>A0A1Y1UFD3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_601847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870317.1">
        <property type="nucleotide sequence ID" value="XM_022013936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFD3"/>
    <dbReference type="FunCoup" id="A0A1Y1UFD3">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFD3"/>
    <dbReference type="GeneID" id="33555744"/>
    <dbReference type="InParanoid" id="A0A1Y1UFD3"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="326" mass="36124" checksum="4027BD2F711C9EFB" modified="2017-08-30" version="1">MSVLELIARKNALEYQSPYGYTPSLAPGVAYLVVFSLLALIHLVLGIKYKYWIIAVTLLPGGIREYQYSWIEIVGWAGRLWSHYSVLNSNPFIMQICTLILGPAFFSAWAYATLGYCIQRLGPRFSLLKPTMYLAVFVTADVVSLILQAIGGGKAAVQAEAGTDTTQATHIMLAGILFQLGTMTIFVALASDFIIRVAANRPYKQRTPRATKPEEDANSDNVADSVTLRVDPEHGVQSREKSTSSSRKDLQRVKVLLGGVAFASLMIYIRGVYRSIELAQGWTGYVITHEAFFTWLDGFPMVLCYAAFAIAHPGWLLPRRSGWRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFE0</accession>
    <name>A0A1Y1UFE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_651487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870348.1">
        <property type="nucleotide sequence ID" value="XM_022018344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFE0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFE0"/>
    <dbReference type="GeneID" id="33560153"/>
    <dbReference type="InParanoid" id="A0A1Y1UFE0"/>
    <dbReference type="OrthoDB" id="2564060at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="192"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="630" mass="70853" checksum="DD5B2A61D58AE791" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFH4</accession>
    <name>A0A1Y1UFH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_675372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870841.1">
        <property type="nucleotide sequence ID" value="XM_022018951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFH4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFH4"/>
    <dbReference type="GeneID" id="33560760"/>
    <dbReference type="InParanoid" id="A0A1Y1UFH4"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="374" mass="40390" checksum="A0ED0CD9CE526D17" modified="2017-08-30" version="1">MLSRRLASTSAVGRSSSRKIVLVGAGFLASYIAKALVIDPKNRIVLVSRHPEKLHHRLTHLGSQILPPVSYDLSSTNTAPLKDVLKDADAVVSMVGLLSASASQMVEIQQRGAERVLQAAMDQGVKRKVLISAIGSDSNGETPYARTKAAAEKAFLSADPTSTIIRPSIIFGPGDSFFTRFASLAKFLPFLPVFGGGTTKFQPVYAGDVARAVEIACRDDPEVIKRVGGKVIEAGGPRVMPYKEIMKLTLKYSGLEGRRLILSLPYWVGMIQGFFLEKLPESLFTLTRDQVKQLKRDNVVTPGPDENAFQNLLASFPPPGPSSAPTASGANLRSVEESLPTYLGSRTPTESGKRTHGRGSSLNEDQVRQMSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL4</accession>
    <name>A0A1Y1UFL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_474325</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870929.1">
        <property type="nucleotide sequence ID" value="XM_022012886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFL4"/>
    <dbReference type="FunCoup" id="A0A1Y1UFL4">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFL4"/>
    <dbReference type="GeneID" id="33554694"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL4"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013005460" description="alpha-amylase" evidence="18">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="36"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="60"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="475"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX36860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="61206" checksum="06F05D147D85579D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFU9</accession>
    <name>A0A1Y1UFU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870961.1">
        <property type="nucleotide sequence ID" value="XM_022018324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFU9"/>
    <dbReference type="GeneID" id="33560133"/>
    <dbReference type="InParanoid" id="A0A1Y1UFU9"/>
    <dbReference type="OrthoDB" id="3333333at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="68"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="197" mass="22995" checksum="45F19C0B100DBC0E" modified="2017-08-30" version="1">MPRKWEEVWETELAPVEKYIEIGPFKGGQNVGVTIPYIQAATLSLPLRIHPLLECMPWMPKITYPRYISWNVVEFPVTAMIKERFQPATSPKVEELHLLHDETGWSIRIANRLGVNVTDVLTGIFDFFASPLAVRVMEQQYFEKREYGFYDTFLGYRKSDALLNKTYFDGIRYDPDEAFKRLNYRATNVMVLSLNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGI4</accession>
    <name>A0A1Y1UGI4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multicopper oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_625060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871209.1">
        <property type="nucleotide sequence ID" value="XM_022015760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGI4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGI4"/>
    <dbReference type="GeneID" id="33557569"/>
    <dbReference type="InParanoid" id="A0A1Y1UGI4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="125"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="265"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="516"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="647" mass="73467" checksum="897C4902643790AA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGS7</accession>
    <name>A0A1Y1UGS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871276.1">
        <property type="nucleotide sequence ID" value="XM_022018218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGS7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGS7"/>
    <dbReference type="GeneID" id="33560027"/>
    <dbReference type="InParanoid" id="A0A1Y1UGS7"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="47"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="370" mass="40854" checksum="DE95B1E59F18DD5E" modified="2017-08-30" version="1">MTNPMMNHPTNPPESTAVREGRSLFGPGWKAVDNFDDLSDIDEYESDEEELYVTLDLGAAVDTRTLLTETDYQLIGLDTPVPFFKLHNQIFRGDVATLLGDEVILGLRRNHENPHNPSHPPLYTTNRRIILHPVALQSLTQEDEPKLISGHAARRRVLGQPSMQGRTRWKGTRGRGVRRESRDTPVTVDDSEGGGEDHPNVPLDPSLRETDPMSMEYTSAGPSKRNPKRIGVEKVINDVDEFNALDINELPPKAKIFLSPGVDLSQIGNGLNEDQRILTRFEVEKIKAGVPLTGRGSRSLRKKKDDEDSAGLANEGEGQEEEEEADEGGDEEVSQGGSDAKRQPSEAQQRDQEVEPAEGADGSKTNQDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGT4</accession>
    <name>A0A1Y1UGT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_437929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871308.1">
        <property type="nucleotide sequence ID" value="XM_022012785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGT4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGT4"/>
    <dbReference type="GeneID" id="33554593"/>
    <dbReference type="InParanoid" id="A0A1Y1UGT4"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="242" mass="26607" checksum="F9FDCAE937057D58" modified="2017-08-30" version="1">MADLKEFLSLLESTVKAPRLSGSKVSLLSTQSKKLEPKSDTEFISTFLRLNKSLGKKSTSRISSLYVFDAIARANKGISGREGLMMKMEGVVDSWVNEMCEDGKGGVWTEGRDKTRKIVDIWTKSSTFPQPCLDRLSARLAVASADHSTTPTMSPPRPIMSPALPPLEEKENRGLGAHGFGQGPVLCLPSVLSSCLRGMLHRSCRVLKVNPILFIAIRVENTSLAILLTVQTHKTEGRRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGY0</accession>
    <name>A0A1Y1UGY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_601037</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871348.1">
        <property type="nucleotide sequence ID" value="XM_022013924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGY0"/>
    <dbReference type="FunCoup" id="A0A1Y1UGY0">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGY0"/>
    <dbReference type="GeneID" id="33555732"/>
    <dbReference type="InParanoid" id="A0A1Y1UGY0"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="654"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="805"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX37310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="918" mass="100385" checksum="7841F6C6D8F765E6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH11</accession>
    <name>A0A1Y1UH11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_440475</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871350.1">
        <property type="nucleotide sequence ID" value="XM_022012792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH11"/>
    <dbReference type="FunCoup" id="A0A1Y1UH11">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH11"/>
    <dbReference type="GeneID" id="33554600"/>
    <dbReference type="InParanoid" id="A0A1Y1UH11"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="13">
        <location>
            <begin position="93"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="519"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="786" mass="89825" checksum="294415BB112A50E0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH21</accession>
    <name>A0A1Y1UH21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRDE-2, necessary for RNA interference-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_625808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871391.1">
        <property type="nucleotide sequence ID" value="XM_022015843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH21"/>
    <dbReference type="FunCoup" id="A0A1Y1UH21">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH21"/>
    <dbReference type="GeneID" id="33557652"/>
    <dbReference type="InParanoid" id="A0A1Y1UH21"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129754" checksum="8699BC2371EF35E3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHB7</accession>
    <name>A0A1Y1UHB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_626130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871460.1">
        <property type="nucleotide sequence ID" value="XM_022015871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHB7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHB7"/>
    <dbReference type="GeneID" id="33557680"/>
    <dbReference type="InParanoid" id="A0A1Y1UHB7"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF885">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="195"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="344" mass="38230" checksum="E57190363AD17164" modified="2017-08-30" version="1">MSLVDLAGQLQRQDFKDIPIIDLSNARSNSVDARRKVAIEVRNACLNAGFFFVQNHGVPKHVVQGGFDAAKVFFEQDNQVKESVDISKSDNFRGYMKLLSGNANPESKGDLHEAFNLGLDPSLDAAPRGHKTSEGLSHSDNLWPTVEVWKGAASFRQAVLGYYSAVLTLGQSLFPLFALALDLPEDFFADKVQHPAAIMRLLHYPGTPKDRQKEENPGIGAHTDYECFTILAQGGVPGLQVMNRKGDWIDAPYIPDTFVINIGDQFARWTNDIFVSTPHRVLPPTQTRYSIPFFFGCDHDVPLIPPPTCITEDRPQKYPVVTAGAYVHSRLSETYTVQQEEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHS2</accession>
    <name>A0A1Y1UHS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_642094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871125.1">
        <property type="nucleotide sequence ID" value="XM_022017465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHS2"/>
    <dbReference type="GeneID" id="33559274"/>
    <dbReference type="InParanoid" id="A0A1Y1UHS2"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37235" checksum="87E3CD3CD8B7308C" modified="2017-08-30" version="1">MNTNSSTETTISPAGVLLLRGSATTPETSYYEDLDKNGWCVVKNVISPEKAAYYVDQAYSWLEGFGKGFDKNDRETWKPENLPAFAKGGLFNRHASGHEQFAWDIRAEPGLIDVFAKIWGTDELAVSFDGVNVSLPFKADAPVDRKPWAHVDQSPLRRFKYCVQGIMNLAPNGPKDGGLMVLQGSFSRYNEFWEAHDHEAPPGGWSKRNGYHHTQAQLQWFYDRGCTWHKVEAGPGDVILWDSRCVHYGAAAEGDQPRVATYVCYKPNRDVAPDKQAIRKEAMENFDNTTHDAADVKQTGSRIAGKLSDDERTVPSKPPVLSHRAQQLAGIAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHV2</accession>
    <name>A0A1Y1UHV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_650172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871589.1">
        <property type="nucleotide sequence ID" value="XM_022018111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHV2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHV2"/>
    <dbReference type="GeneID" id="33559920"/>
    <dbReference type="InParanoid" id="A0A1Y1UHV2"/>
    <dbReference type="OrthoDB" id="2564497at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57883" checksum="F9AA6BA3E64E8ABD" modified="2017-08-30" version="1">MAYPFQKMCTFPGCDRKTRGPAAMCTELCEAFLCPAHRKPEFHPCLLLTGITTMKEQADLWATASIQDWVMLHESMSREAIEGEASRLRPGHSCVLNAPQDGTVGMFLLEQATTDEDNLRLTELWRSWTPLETGGMSHFNHHYQLTFDDGVKWMLRCKRLRADRPASDYILFAVMKSEIQTMDFLREAGLKIPKVYRPSGTIKAPITEKHRWRMYFFSEYITATKLPLQVFPVTMKEDRLKGLSLTVAKQVVRFYAEQMILISHKPFSAMGSLYPGKDGGPAYVGPMIDPWIGFRKKPYFYGPFTHPRDRWLTFINHQLDLALNHHGFNGDPIDNYLLLRDLMAVIEEWKELDKPATEFYVKHVDSKGDMLFIEPDGSIAAWIDWEWAIVRTKEEAFAAPLLKDTYEELGRSDLAACVKKGFCYPSLIEVCSAFGPDLRPAYEYKKVRGLLLGTGGGTKVSIKAAKEWLQGLRQTYRDDPGYQQVLASQGRMSEASVILEASSSNPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI53</accession>
    <name>A0A1Y1UI53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative S-adenosylmethionine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_623031</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871715.1">
        <property type="nucleotide sequence ID" value="XM_022015542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI53"/>
    <dbReference type="FunCoup" id="A0A1Y1UI53">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI53"/>
    <dbReference type="GeneID" id="33557351"/>
    <dbReference type="InParanoid" id="A0A1Y1UI53"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="211"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="317" mass="33933" checksum="61A5DD9ECA2067F9" modified="2017-08-30" version="1">MHPRTIEPWCCYITDMSGEDGESSEHPERPPSFQRALLAGAISGVAVDFILFPLDTVKTRIQSAQGFVKSGGFKGVYNGVGSVGIGSAPGAASFFVTYEALKSRLPKTFDTLATSPGLNHLVSASGAEFMSCLIRVPTEVIKSRTQAGTYGKGKSSLHSAIMTARNEGIRGFYRGFGITIVREIPFTSIQFPLYEGLKTQLSVQYLDGKRPTPVQAALCGMIAGGTAAALTTPLDVVKTRVMLEAQAAKGSHRPSPSVLSFPPRLVAIFRNEGIKALFGGWQPRTLAISFGGAVFLGIYDFFVHWGLPRGTIQLPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI73</accession>
    <name>A0A1Y1UI73_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mitochondrial inner membrane citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_625376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871275.1">
        <property type="nucleotide sequence ID" value="XM_022015790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI73"/>
    <dbReference type="FunCoup" id="A0A1Y1UI73">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI73"/>
    <dbReference type="GeneID" id="33557599"/>
    <dbReference type="InParanoid" id="A0A1Y1UI73"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="109"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="206"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="297" mass="32115" checksum="9B0A84CE27FD0CA9" modified="2017-08-30" version="1">MSAANKGKSREKPMASLCAGAIAGGFESFATYPLESLKTRLQFGALEGGKPLTPLQALRETLNQGGTRALYAGCTAVVIGNAVKAGVRFTTYDQFKSLLKDDEGKLTAPRSMLAGLGAGMMEAIIAVTPSETIKTKMIDDSKRAQPRFHGMSDAVRTIVREEGISGVYRGLGPVILRQGANSAVRFSSYSTLKQLAQGSVVPGSQLPGWMTFGIGATAGVITVYSTMPFDVVKTRMQSLKARQEYRNSLHCAYRIFTEEGVLRFWKGTVPRLGRLILSGGIIFTVYEKTYPLFDSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIE2</accession>
    <name>A0A1Y1UIE2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_627481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870934.1">
        <property type="nucleotide sequence ID" value="XM_022016004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIE2"/>
    <dbReference type="FunCoup" id="A0A1Y1UIE2">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIE2"/>
    <dbReference type="GeneID" id="33557813"/>
    <dbReference type="InParanoid" id="A0A1Y1UIE2"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="392" mass="43318" checksum="0843CC3DB5D4C945" modified="2017-08-30" version="1">MVADRTYYDLLEVSIDADEVEIKRAYKRKAMLHHPDKNPDDPQAHEMFQKIGQAYETLCDPNNRAAYDEYGPDGAPRGFDGGVDMDDIFAEMFGGASFGFGGGFSFDSAGPGPSRRKPTRGPDTVVDYNVTLEEAYKGKRVVMGLERDRVCSHCHGSGARTGVKPSKCKTCDGKGSVIADRHLGPGLVGKMKVTCTDCHGEGTRLRDKEKCKKCKGAKVLRDKKRVEFHIQPGTEDGERIALKGEGDEAPDIPPGDVIFHIHHKTHPFLRPHPSHPSNLRTTVRISLSEALLGFSRVFFVHLDGRGIRIDSGRGERVINPGDEWLIRGEGMPRIGREDKGDLYVKFEVEMPGASWAARQDPSGTTVQLPPALPEMSPLPDTVETRYLSPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIE6</accession>
    <name>A0A1Y1UIE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_623449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871807.1">
        <property type="nucleotide sequence ID" value="XM_022015582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIE6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIE6"/>
    <dbReference type="GeneID" id="33557391"/>
    <dbReference type="InParanoid" id="A0A1Y1UIE6"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="960" mass="105298" checksum="3AD3F0DA3344C1C6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIS1</accession>
    <name>A0A1Y1UIS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_623602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STEEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871856.1">
        <property type="nucleotide sequence ID" value="XM_022015606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIS1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIS1"/>
    <dbReference type="GeneID" id="33557415"/>
    <dbReference type="InParanoid" id="A0A1Y1UIS1"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029704">
        <property type="entry name" value="STEEP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355:SF1">
        <property type="entry name" value="STING ER EXIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46355">
        <property type="entry name" value="UPF0428 PROTEIN CXORF56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="3">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="157" mass="17267" checksum="55544073169A9701" modified="2017-08-30" version="1">MPKVVSRAVVSSSESAQPTQSARAVLRSYYCLCGDFVLVIQGKLDRLPKRKHDGSFIIRAQAGKNPVTQPARKFKLNARPGERCLIKRNGTQDLEVRQPFVCGRCNTTVAYQTGPPPSGESPFLYIPKGSMTELQGRIPPDAFDGEEHLPAKELLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ50</accession>
    <name>A0A1Y1UJ50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871564.1">
        <property type="nucleotide sequence ID" value="XM_022018107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ50"/>
    <dbReference type="GeneID" id="33559916"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ50"/>
    <dbReference type="OrthoDB" id="5279375at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="100" mass="9984" checksum="CFB3786958674A24" modified="2017-08-30" version="1">MSYKPTEHDGKTLSGEPDKRVSSEHGFGGSDGPDPHVEGQKGGKASGGGGAGSGGEAYKPTEHGGLKQDGTPDKRVSSEHGFGGSDGPDPHVEGQKGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ93</accession>
    <name>A0A1Y1UJ93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871533.1">
        <property type="nucleotide sequence ID" value="XM_022015464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ93"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ93"/>
    <dbReference type="GeneID" id="33557273"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ93"/>
    <dbReference type="OrthoDB" id="10248513at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="372" mass="41245" checksum="1B021ED5EE77B387" modified="2017-08-30" version="1">MTAIELSKDSTMNIPQVSLDIYLKDPDSTEAHNEAVGAAESLILTGAVVVRDCRAPKEANDRFIDLFEDYFAQEKDVLKQDERPEIGYQVGVTLENTEKPKCGSDDECLAVISALKEDQRPLDISGHGADPKCRFFHRMSIPPPSDTIFPATSAPNVVPEAFKDDWTERVTEWGTFMKQSVEGVAMMVAQGLGLHRRTFIDAGKYGSHLLAPTATDLTKYGQRDTIFAGFHTDLNFLTIHGQSRYPGLHVWARNVGEKIPVKIPEGCLLVQAGKQLEWITGGYIKAGYHEVVCTDATLAAMNRRKTAFPQRPLIRISSTFFWHLSPDHLLVPIPGLQACAEAQFGPQKDYGEMLVGNQVLQELGLIALFEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJC1</accession>
    <name>A0A1Y1UJC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_433797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871253.1">
        <property type="nucleotide sequence ID" value="XM_022012772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJC1"/>
    <dbReference type="GeneID" id="33554580"/>
    <dbReference type="InParanoid" id="A0A1Y1UJC1"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="312" mass="34539" checksum="A5C8BA6006B5775C" modified="2017-08-30" version="1">MSPYPSHVVTGPAESSTVTLHRFVARAADSTPNQFQTNTVIVACVMFVIILIAWNVPILREIISGLKLFVTGCHELSHLVVGLLCGGQVVSICIDPNDGGATHIMGLMRTYPRVPRDPYAMPTYSQLFWSSSAVATLGAGYVGSSIFGFLFIFCAFHIVASKAAALVIHIGLLVPILRADHWIAFASIIVCEAVLIGLWFGDHGNALRFYILFVGVMSLFYVVWDYLDERLFDKRNTSDCAQFSELLGWPISGWAVFWFIYSGLVFTAAIFAGIIVFRVRPGQTRPSEKLIQISQRTDEQMYSEAAKFLPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJZ7</accession>
    <name>A0A1Y1UJZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_649753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872303.1">
        <property type="nucleotide sequence ID" value="XM_022018042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJZ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJZ7"/>
    <dbReference type="GeneID" id="33559851"/>
    <dbReference type="InParanoid" id="A0A1Y1UJZ7"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="202" mass="23050" checksum="A20913EB20E468C9" modified="2017-08-30" version="1">MNGFRNLKISEIFVDHRSPRISRQKAVKRHASAVQLPVKRSFAVDETQVVESVVPGNEPGPSRLKPTRPPMESSTEPPVPAHPYSRSHVRREKRKAKQQLAGGQLHDMAVALSQSLGETEPESKARVRTKEEKEKERQRREQEQKVGAVGKSRTLKERKRRKEITTEARRLPAVVNLPVFKQNPWETIRIHATNTIALKDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK63</accession>
    <name>A0A1Y1UK63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_620662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872311.1">
        <property type="nucleotide sequence ID" value="XM_022015309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK63"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK63"/>
    <dbReference type="GeneID" id="33557117"/>
    <dbReference type="InParanoid" id="A0A1Y1UK63"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="34306" checksum="9996005331EBC4E7" modified="2017-08-30" version="1">MKHFCRSLPTRPGPRLLRLTSESSSKSTILHAARPSPVFTVPHHHRPFTMSADVLAPQEVVYSTNSDRPPMPSDVATGEHTAQKTDAYLDTKLLAPGYGADQVLEKCRKRAHEAGIPEIAVSPQQGQLLSILAKSVGASKILEIGTLWGYSTVFLARSLPKHGQIDTLEIDPLHAKISNQTFIDADLYPFPKIHIGKAVDTLKGLSPPGEAEGLKDAGYDFVFIDADKGNIPEYFQQALRLSRKGALIFIDNAIRGGRITSEYRSNTHEDANIAGLRKFYDWAEKDNGKTVLLSGTQTVGAKHWDGFVLATKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKA2</accession>
    <name>A0A1Y1UKA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_680220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872412.1">
        <property type="nucleotide sequence ID" value="XM_022019071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKA2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKA2"/>
    <dbReference type="GeneID" id="33560880"/>
    <dbReference type="InParanoid" id="A0A1Y1UKA2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16667">
        <property type="entry name" value="RING-H2_RNF126-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="461" mass="48516" checksum="B8D3133F1414104D" modified="2017-08-30" version="1">MSTNASQAFWICHECGAQMRPLTVDGVSHCASCNGEFIEILDSNINPDPYFELPPPPPIRPTGQEPPSQHNPGLAEGNFMSSLFGNIFGAAVRDPGGSGQQPGSQRPGSPSSALGTSPGRSSGSSGGRGRTLNFNLPGGGRGQVMFGSFGGNGIGIGAIGSGDDGGLGMPGSGGDLASFFPGFGPPPHLQRGGNRHFQPLGQNDAMSPDELIRSMLAALTIDGDMPQIHGIPGRANLGDYVLSQQGFDQVLEQLMRAAGPQGPLPASDIVINGLPKFKLTEESLETSQFKDCPVCKEEFTVGEEVKRIPCKHIFHPDCVDPWLKVNGSCPVCRFSLVPDESNGPPRTTGTDTDSPDTETRDPQQGSYVSNVLRRLWGQTGTNSDPSSPTTEDPPDAAGEATAVTTSGRVPSESPPPASAAPQAASGEPVVRLSTDIPAEYTERHRRREREARESLPDEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKC4</accession>
    <name>A0A1Y1UKC4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_641773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871562.1">
        <property type="nucleotide sequence ID" value="XM_022017445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKC4"/>
    <dbReference type="FunCoup" id="A0A1Y1UKC4">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKC4"/>
    <dbReference type="GeneID" id="33559254"/>
    <dbReference type="InParanoid" id="A0A1Y1UKC4"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="992" mass="108301" checksum="A18EAD72EEEC63AC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKF2</accession>
    <name>A0A1Y1UKF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_577929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872455.1">
        <property type="nucleotide sequence ID" value="XM_022013285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKF2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKF2"/>
    <dbReference type="GeneID" id="33555093"/>
    <dbReference type="InParanoid" id="A0A1Y1UKF2"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="435"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="502"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="848" mass="94858" checksum="DC4A8FE7AD1D728D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL10</accession>
    <name>A0A1Y1UL10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_619831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872088.1">
        <property type="nucleotide sequence ID" value="XM_022015213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL10"/>
    <dbReference type="GeneID" id="33557021"/>
    <dbReference type="InParanoid" id="A0A1Y1UL10"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="11">
        <location>
            <begin position="26"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="345" mass="37897" checksum="EA2B0F1248EB5BD5" modified="2017-08-30" version="1">MLFLLALLAPLVSAAPTKRWECASTNNSQCSLASLAERSGKLYFGTAYQSFYMAAEGFTPVLDSEFDQYTPENEMKWSVIQPEPNVFNWTGSDLIIAHAKKTGSIVRGHNFCWDSQTPGYVTNITDPDELKSVLKSHIDAVLGRYGNDLYAFDVINEPLNDNGTFKSNVWYNVLGEDYLGIALDYAHAAAPNLNLYINDYNIESVNNKSQAMAKVAQGLLAAGKPLNGIGFESHFIGGETPDDIAESMKQFTDLGLDVAITELDVRVPVNNMGIANSTWLEIQAKDYAQVVSVCLNNTKCPGVTVWGFADYFSWIPGVFAGYGAADLYGFTYQPKPAFYAVQDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL16</accession>
    <name>A0A1Y1UL16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WH1 domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_376200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872601.1">
        <property type="nucleotide sequence ID" value="XM_022012622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL16"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL16"/>
    <dbReference type="GeneID" id="33554430"/>
    <dbReference type="InParanoid" id="A0A1Y1UL16"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000010">
        <property type="entry name" value="Related to Neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="9">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="11">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX38679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="46489" checksum="DEF85D9AAC204C75" modified="2017-08-30" version="1">MGKPTLLSAEDKAKIKKAIPTSSSTNKIITAAVARIYQAKEGTSTWSYAGVTGALVFCADKAKGGLWFRLVDLSSYQGVLWEHELPNEIEYNQEKPFFHSWQGDTGSIAFVFASEAEANDFYKKVAHRSKYATKVKEDKKEKKEKESTPTKKSKKEKGKIDKSLISGPSAGSFKHVAHMGYDSEKGFSSSGVDPSWQTLLEQLAAKGVSAKDIKKNEKFIREYVEQQGGIENAAARKPPPPPTSRRKPAPPPPSSRSARPSSVAIPPPPPPPPGRPASTAAIIPPPPPPPAPPRGGASIPPPPPPPPAPPGRSPAAPPPPPPPPGGSRGAPPPPPPPPPGGRGGAPPPPPPPPSGPPAGAGGNARSALLASIQGQGVHNLRKVDPSEQKVSPLAGAAGGAAVGAVAGGAAVAAAGGGDDQPDLASSLAAALAKRQGDLGESDSEEGSDDEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULG4</accession>
    <name>A0A1Y1ULG4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trehalase</fullName>
            <ecNumber evidence="2">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_620515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 2">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872276.1">
        <property type="nucleotide sequence ID" value="XM_022015294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULG4"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULG4"/>
    <dbReference type="GeneID" id="33557102"/>
    <dbReference type="InParanoid" id="A0A1Y1ULG4"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012010942" description="Trehalase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="807" mass="87644" checksum="91BABF6271079B4C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULV2</accession>
    <name>A0A1Y1ULV2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_305093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872893.1">
        <property type="nucleotide sequence ID" value="XM_022012441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULV2"/>
    <dbReference type="GeneID" id="33554249"/>
    <dbReference type="InParanoid" id="A0A1Y1ULV2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="61610" checksum="835E8D30048B0A9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM37</accession>
    <name>A0A1Y1UM37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_649946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872509.1">
        <property type="nucleotide sequence ID" value="XM_022018065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM37"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM37"/>
    <dbReference type="GeneID" id="33559874"/>
    <dbReference type="InParanoid" id="A0A1Y1UM37"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013344947" evidence="3">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="5">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="43245" checksum="4D32A46DD6C3FC62" modified="2017-08-30" version="1">MTSTVNIAILGSGLFALHAYLPNLLTPENKHINLHTVWSRSESSAQKLVDAAKEKSGGSVSPRLTFGDDGLETVLNDKEIQGVMLVLPIRTQMDLVFKCLKAGKHVLSEKPIGTDVAAARELVDEYEKTYKPKGLIWRVAEDVDHEPMVHKAAEKVRDPALGPVLYWSMEAHGYIEDASMYHATEWRTIPDYQGGFLLDGGVHDAALIRLVLPNPPEQIISSANLHRNHIPPHDIVQAIALSPSTETEAHGPASKLKGIRGRDEIPGGIGRSSSTGTIVFSFAIADLDSKPPKGIIVNCLNGTVRLQMVAGNWKLEVQPGKGTNVKPFTEEGKRVGVREECAYFARAIAALKDGQQVDEKESRGNPRHMLWDVALIEALLTSNGEKVDMQKLLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM51</accession>
    <name>A0A1Y1UM51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_649171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872942.1">
        <property type="nucleotide sequence ID" value="XM_022017945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM51"/>
    <dbReference type="FunCoup" id="A0A1Y1UM51">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM51"/>
    <dbReference type="GeneID" id="33559754"/>
    <dbReference type="InParanoid" id="A0A1Y1UM51"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="560" mass="62016" checksum="71FC0B684150D53F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMB8</accession>
    <name>A0A1Y1UMB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_576541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873053.1">
        <property type="nucleotide sequence ID" value="XM_022013195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMB8"/>
    <dbReference type="FunCoup" id="A0A1Y1UMB8">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMB8"/>
    <dbReference type="GeneID" id="33555003"/>
    <dbReference type="InParanoid" id="A0A1Y1UMB8"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="77"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="303" mass="32807" checksum="2D35A0F378A06267" modified="2017-08-30" version="1">MTIVDKLKEKLHLGGNSKSVASESPAVPPKSSASSNPAVPPKDASPVATKDSLPDLPETEVFDHEKVTVIFVLGGPGAGKGTQCENLVRDYGFKHLSAGDLLRAEQTREGSEYGDMIKQCIVEGQIVPMEVTVKLLENAMRDTLAKPPSVSSELSSAWEGGKGRFLIDGFPRKMDQAIKFDEAVCQSSFVLFIATTEEVMLERLLERGKTSGRSDDNEESIKKRFKTFEETSMPVVDYYRSKDKVVEASIDSSPPVQEVYQAVRAAIDPRLGVTAPQPVSGIPEPVAAVEPVHDEPAVLGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMH5</accession>
    <name>A0A1Y1UMH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872616.1">
        <property type="nucleotide sequence ID" value="XM_022018081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMH5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMH5"/>
    <dbReference type="GeneID" id="33559890"/>
    <dbReference type="InParanoid" id="A0A1Y1UMH5"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF2">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="347"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="561" mass="60409" checksum="0E22F22333068B85" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN12</accession>
    <name>A0A1Y1UN12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_587615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872699.1">
        <property type="nucleotide sequence ID" value="XM_022013756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN12"/>
    <dbReference type="FunCoup" id="A0A1Y1UN12">
        <property type="interactions" value="824"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UN12"/>
    <dbReference type="GeneID" id="33555564"/>
    <dbReference type="InParanoid" id="A0A1Y1UN12"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="7">
        <location>
            <begin position="952"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110542" checksum="5F1F34D6D492EA3E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN35</accession>
    <name>A0A1Y1UN35_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_679449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872790.1">
        <property type="nucleotide sequence ID" value="XM_022019040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN35"/>
    <dbReference type="GeneID" id="33560849"/>
    <dbReference type="InParanoid" id="A0A1Y1UN35"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="160" mass="17819" checksum="333CFBE7252EED89" modified="2017-08-30" version="1">MAILDSHNNAAEMFEAYIAAVFFSADSLDSTKANAFAILNEWLEPIMDQLAAEEQHDGVSIASDDSQLDRDASGSKSRLHEMQQRLYITELNYQEKSMVPGGAKGTQGLRWKVSCSARYNGLYIAHGVVRDTKKKAAEVAAYLVLNEIKDTGFRMRLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNJ4</accession>
    <name>A0A1Y1UNJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_618469</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872950.1">
        <property type="nucleotide sequence ID" value="XM_022015030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNJ4"/>
    <dbReference type="FunCoup" id="A0A1Y1UNJ4">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNJ4"/>
    <dbReference type="GeneID" id="33556838"/>
    <dbReference type="InParanoid" id="A0A1Y1UNJ4"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="280"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX39087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="432" mass="48086" checksum="1DD42C7A54B27469" modified="2017-08-30" version="1">MWNFSPRSEKKERVDTTSLSLFNTIPYTMSFQRSSARALRAATKAAAQPTSQHVAKRSISMLSRTAPRVTMNTRATGVRGIKTLDFAGTKETVYERGDWPLDKLQEYFKNDTLAMIGYGSQGHGQSLNARDNGLKVIVGVRKGGESWKQAQEDGWVPGETLFDIPEAINKGTIIMNLLSDAAQSSTWPEIAPLITKGKTLYFAHGFSVVYKEDTKVVPPKDVDVILVAPKGSGRTVRTLYLEGRGINSSIAVYQDVTGKAKEKAVALGIAVGSGYLYETTFEKEVYSDLYGERGVLMGGIQGMFLAQYEVLRKNGHTPSEAFNETVEEATQSLFPLIGKYGMDYMYNACSTTARRGALDWAPKFKEANLPVFEALYKSVRDGSETRRSLDFNSRKTYRQDLQKELDEIDNQEIWRAGKTVRGLRPDANKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNM7</accession>
    <name>A0A1Y1UNM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_614356</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873404.1">
        <property type="nucleotide sequence ID" value="XM_022014588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNM7"/>
    <dbReference type="FunCoup" id="A0A1Y1UNM7">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNM7"/>
    <dbReference type="GeneID" id="33556396"/>
    <dbReference type="InParanoid" id="A0A1Y1UNM7"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="130" mass="13805" checksum="BD1D2AD36EBFA486" modified="2017-08-30" version="1">MSGKGGKSGADTKSSSRSSKAGLQFPVGRIHRLLKKGNYAPRIGSGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIVPRHLQLAVRNDEELNKLLGHVVISQGGVLPNILNELLPSKTKKGVKASLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNS3</accession>
    <name>A0A1Y1UNS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_641355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873050.1">
        <property type="nucleotide sequence ID" value="XM_022017417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNS3"/>
    <dbReference type="FunCoup" id="A0A1Y1UNS3">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNS3"/>
    <dbReference type="GeneID" id="33559226"/>
    <dbReference type="InParanoid" id="A0A1Y1UNS3"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="372" mass="40316" checksum="DE1018A1F02B8C8F" modified="2017-08-30" version="1">MTDYCYFDITIAGQPAGRITFELYSAYLPKTTENFKALCIGDKTNDAGVKLAYAGSSFHRCIKGFMLQAGDFTRGDGTGGLSIYGEKFSLTCPDEAFIHEHDKPMLLSMANAGPNTNGSQFFITTVPTPHLDGKHVVFGQVVTGKALVRRIENIPTTSDKPNEPVTIAAAGVLSKEDIEAERKKIQDSKGEDPYEEYPVDEESINVDKPEECATAAEKLKEVGTTAFKAGDFAKALGKYQKALRYLDQNPVLPDGTDKAVAETQRKLRIPLLTNSALAALKSDPPANSLAVTLASKALAVSDLTPEEKGKALYRRALAKTALKDEDGATKDLKEALEAVPGDANISRALKNVEVAKKARLEKERKAYSKMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNS7</accession>
    <name>A0A1Y1UNS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_614496</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873437.1">
        <property type="nucleotide sequence ID" value="XM_022014602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNS7"/>
    <dbReference type="FunCoup" id="A0A1Y1UNS7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNS7"/>
    <dbReference type="GeneID" id="33556410"/>
    <dbReference type="InParanoid" id="A0A1Y1UNS7"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="39701" checksum="3C8586A96D2ECEF3" modified="2017-08-30" version="1">MPGTGKGALSIVPAGVITGDNVRKLFEYARENKFAIPAINVTSSSVVNACLEAARDINSPIILQVSQGGAAFFGGKGLANGNQEASIAGATAAAHFIRSIAPLYGIPVVLHSDHCAQKLLPWFDGMLDADEAYFKEHGEPLFSSHMLDLSEESKEENIATCVKYFERMAKMNQWLEMEIGITGGEEDGVDNTGIDNASLYTQPEDIWDVYSALSKISPNFSIAAGFGNVHGVYKPGNVKLRPDILGKHQEYTAKELKKEGEKPLFLVFHGGSGSTKEEIREAVTNGVVKMNVDTDTQWAYLSGVRDFVLKKKDYLMSQVGNPEGADKPNKKQYDPRVWVREGEKVLVERVKEACRDLGNENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP94</accession>
    <name>A0A1Y1UP94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873638.1">
        <property type="nucleotide sequence ID" value="XM_022017846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP94"/>
    <dbReference type="GeneID" id="33559655"/>
    <dbReference type="InParanoid" id="A0A1Y1UP94"/>
    <dbReference type="OrthoDB" id="2565314at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="601" mass="63802" checksum="3F8330563DDEE2B0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ13</accession>
    <name>A0A1Y1UQ13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_614514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873442.1">
        <property type="nucleotide sequence ID" value="XM_022014605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ13"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ13">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ13"/>
    <dbReference type="GeneID" id="33556413"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ13"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.780:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="516"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="844" mass="93671" checksum="8370D0E680D6B87E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ87</accession>
    <name>A0A1Y1UQ87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_614531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873449.1">
        <property type="nucleotide sequence ID" value="XM_022014609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ87"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ87"/>
    <dbReference type="GeneID" id="33556417"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ87"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="30331" checksum="6F64941BFC714404" modified="2017-08-30" version="1">MPGKTAKDLKCQVCHESSAKYRCPGCPTRYCSVQCFKLHKLNACQADAKPDVDASKVEETLVKPDPDGILDVGGIATPNEEPPSVKARDGPLKPLTELLWPPEPDPSIFMDPLTREDPKPLRHEELLRIATSSSLRYLLSSTPLPRILKILDSLPTASARSSCLARLLGLDPISMAKPDNPILNQRDSPPPLEDLLRAAIGENKSETGSGAWADDEGWWLECKRGEGPRSDNERIWIGSEERRVMRLFASVVCREIDGDKADSSSMGKGHLEWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ99</accession>
    <name>A0A1Y1UQ99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_614559</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873459.1">
        <property type="nucleotide sequence ID" value="XM_022014613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ99"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ99">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ99"/>
    <dbReference type="GeneID" id="33556421"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ99"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="12">
        <location>
            <begin position="42"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="11">
        <location>
            <begin position="224"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="500" mass="54757" checksum="DEA0ED7CB3BA8815" modified="2017-08-30" version="1">MASRLEEPENEPTQRPSTSYSNLAELSAPFHIDPAQRSYRHQYSNIYFVRLVELRPIVERNAQARWGGVRGKPPLLPRILNLQKGQLCYIVGTVYLEMPLKPNVLEDMARDHWIAPPAPRAKFFSGQDAVHLEDESGRVRLVGEVIRRERDRENGGLVTGIIMAALGMETSAGDFEVIDLCFAGLPELYTPQAGPSNGGSHTKGKSKADANGQGDTDHRNETWIAIVSGLSVGSQEAPADLKSQLLVEWLLGEDGGPLDGEAGDRIARLILAGNSLSQPIRGEDDKKPKRFNSTAKPLYTNHPTKTLSVLLNDLLSSSLPVTMVPGPSDPAGATLPQQPLPKVMFGGKKAGGLDCTTNPTWLEIGGRSLLVTGGQTLDDIYKYVPSEGRLGMAQRTLEWRHVAPTAPDTLWVYPFPDADPFIIHKRPELYIIGNQPEFQTTVVGDDSPTRIILVPSFAKTGQIVVCCLETLETKTIGFEVPDWEGETKTNGDLEVDVKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQJ1</accession>
    <name>A0A1Y1UQJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874044.1">
        <property type="nucleotide sequence ID" value="XM_022017898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQJ1"/>
    <dbReference type="GeneID" id="33559707"/>
    <dbReference type="InParanoid" id="A0A1Y1UQJ1"/>
    <dbReference type="OrthoDB" id="2560477at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666036" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23399" checksum="58698AC72CA1F3FC" modified="2017-08-30" version="1">MYKLFAALAAIAPLASAAPALNWVKRSESLSCVQYQYTPPFDSPGLNGFIHLYSNVTQSDGSFSETRLGINANGELQPCGECQSTQQFGFEVCQGSESRKGYNGLGNSAGSFYGHILFTNNQATIQCLKAERNPVNRSTIIVADCEYDYDNVMNSDQYWEVASGRVTRLRASDGSYYGGSYGINPDVQQDQPIQIFDGPATGPFTYLGWKAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR29</accession>
    <name>A0A1Y1UR29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_615601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873729.1">
        <property type="nucleotide sequence ID" value="XM_022014742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR29"/>
    <dbReference type="FunCoup" id="A0A1Y1UR29">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR29"/>
    <dbReference type="GeneID" id="33556550"/>
    <dbReference type="InParanoid" id="A0A1Y1UR29"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="140" mass="15465" checksum="85924CA01D2B3BCF" modified="2017-08-30" version="1">MSAVQCFGKKKTATAVAHVTPGRGQVRLHGSPISVVEPSMLRYKIYEPILVVGPEKLANLDIRIRVKGGGQVSQLYAIRQAIAKGIVAFYAKNEDAASALELKKTLITYDRTLLVADPRRMEPKKFGGRGARARRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR45</accession>
    <name>A0A1Y1UR45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_615469</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873691.1">
        <property type="nucleotide sequence ID" value="XM_022014726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR45"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR45"/>
    <dbReference type="GeneID" id="33556534"/>
    <dbReference type="InParanoid" id="A0A1Y1UR45"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="328" mass="35629" checksum="D7D3144ED7827CF0" modified="2017-08-30" version="1">MIYFNSFKDPSCPFLLVYLSIGPGIPARTASSMIVCNHCGTSMDGVDGPCTGCSGKGIAITSPLQTGSSESRNSDRWANNYTDSPNSKENRGSSSPGTCMNTRNAVVPPSASFDVLCPDNGQIKLTRVHGCLLDPKIVLPQCSNCNSSIPAGKKLFVPPSRSGSTFCRLCYSTLFSLGVCHLCKAAVLGDKEEGFGGRHVKGLNAKIWHARCFACVHCAINLFDIDHVVLEDQPQCRSCATVFVPPVAPTENRARRYIRPGEMRVQRDLSEPPTTIRTHVSATMRPEQATLRSPVQQRSSFQTVMAIQAKAGLVRQMQQVFERGGTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR85</accession>
    <name>A0A1Y1UR85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_247631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873769.1">
        <property type="nucleotide sequence ID" value="XM_022012276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR85"/>
    <dbReference type="FunCoup" id="A0A1Y1UR85">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR85"/>
    <dbReference type="GeneID" id="33554084"/>
    <dbReference type="InParanoid" id="A0A1Y1UR85"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="259"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="524" mass="54870" checksum="2D2980132DBE46C9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR86</accession>
    <name>A0A1Y1UR86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_677953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874168.1">
        <property type="nucleotide sequence ID" value="XM_022018963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR86"/>
    <dbReference type="FunCoup" id="A0A1Y1UR86">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR86"/>
    <dbReference type="GeneID" id="33560772"/>
    <dbReference type="InParanoid" id="A0A1Y1UR86"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="27"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59503" checksum="E181AF9C1B554BE8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URF3</accession>
    <name>A0A1Y1URF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_611632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874327.1">
        <property type="nucleotide sequence ID" value="XM_022014291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URF3"/>
    <dbReference type="STRING" id="4999.A0A1Y1URF3"/>
    <dbReference type="GeneID" id="33556099"/>
    <dbReference type="InParanoid" id="A0A1Y1URF3"/>
    <dbReference type="OrthoDB" id="2595969at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="283" mass="30458" checksum="D985B49044452560" modified="2017-08-30" version="1">MNDPLSPLTVPPPRYLLESDSSDEEGQGSYLASRLKTASASVPSFSIQWADAESSFDTVVVSTGQAGKYIARKAGASSPCLTMLMDSEVMGHGYRCAQDLIIVLDDEIDEAQPAVWEGANALLGVQANKWIIAAAYLPSIYITDESESPYKFHPIRYLHIRGPDPQLDKSGARRLSPPNFVTGLPASISSIASHPSSPLPLSSPVTTLLLPLPLSSIPSDHFNASIAAISSSLGKSLTSHAKASGSRWTEEHDEQFSAPGMGGKRKWRDNKQAAREDISVMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URT4</accession>
    <name>A0A1Y1URT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_612031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33503"/>
            <dbReference type="ChEBI" id="CHEBI:6076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33504"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874439.1">
        <property type="nucleotide sequence ID" value="XM_022014335.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1URT4">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URT4"/>
    <dbReference type="GeneID" id="33556143"/>
    <dbReference type="InParanoid" id="A0A1Y1URT4"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1246"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1320"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1366"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1398"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1520"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="194"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="895"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1544"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1544"/>
            <end position="1559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1567" mass="175480" checksum="66C47BBAE456D560" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URT6</accession>
    <name>A0A1Y1URT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase family C78-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_606519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874358.1">
        <property type="nucleotide sequence ID" value="XM_022014020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URT6"/>
    <dbReference type="STRING" id="4999.A0A1Y1URT6"/>
    <dbReference type="GeneID" id="33555828"/>
    <dbReference type="InParanoid" id="A0A1Y1URT6"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="229"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="634" mass="70281" checksum="CDF49209AB1B71E1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URV4</accession>
    <name>A0A1Y1URV4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_574437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874378.1">
        <property type="nucleotide sequence ID" value="XM_022013062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URV4"/>
    <dbReference type="FunCoup" id="A0A1Y1URV4">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URV4"/>
    <dbReference type="GeneID" id="33554870"/>
    <dbReference type="InParanoid" id="A0A1Y1URV4"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="5">
        <location>
            <begin position="168"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="638" mass="69293" checksum="4849966A064D5850" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URX5</accession>
    <name>A0A1Y1URX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_616743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873981.1">
        <property type="nucleotide sequence ID" value="XM_022014856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URX5"/>
    <dbReference type="STRING" id="4999.A0A1Y1URX5"/>
    <dbReference type="GeneID" id="33556664"/>
    <dbReference type="InParanoid" id="A0A1Y1URX5"/>
    <dbReference type="OrthoDB" id="116827at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="351" mass="37439" checksum="908DF80400AB819A" modified="2017-08-30" version="1">MVRSHARNNTTQANLTYYERSLLRQPNAAKRIGGESFKPLDSCNLCLSTVTDPVACGKGHVYCRECAIGNLISQKAGIEVQKRELERLALLEEKEREEARAKARARVVADFERGMGLGVGANAIGSGIGSSSNKTNDGVKAGTTGRFTFNQSAMEDASLKAEEKALAKIEAELAESRKAKLPAYWLPSMAPEAKAPALKDIKLQTVCQVGKDGPHPMARKTLLPVILTYPPASTSKPICPSCTKELSNSTSSILLKSTLPPASSASVALDSHQEDGPKKKKSKKEKGKEEQVCGHVICKTCADTIVKPTRRCPVCEATIGSADMVPLGKEGTGFAAAGGAEVKKDTVVFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US27</accession>
    <name>A0A1Y1US27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ard1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_612082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874458.1">
        <property type="nucleotide sequence ID" value="XM_022014347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US27"/>
    <dbReference type="FunCoup" id="A0A1Y1US27">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US27"/>
    <dbReference type="GeneID" id="33556155"/>
    <dbReference type="InParanoid" id="A0A1Y1US27"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000098">
        <property type="entry name" value="N-terminal acetyltransferase A complex catalytic subunit Ard1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="162" mass="18662" checksum="B9F556BA0A48991C" modified="2017-08-30" version="1">MDIRQATIDDFLGMQNANLLNLPENYTFKYYLYHALTWPELSYVAVDPRGRIVGYILAKMEEEPTDEPSGHVTSISVLRPYRRLGLANRLMKQSQEAMVAHYNAAQITLHVRKSNRAAISLYRDSLGFEVHVMEKGYYADGEDAYGMRFLFKRKDEESKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US66</accession>
    <name>A0A1Y1US66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3 15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_644155</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 15"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874549.1">
        <property type="nucleotide sequence ID" value="XM_022017586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US66"/>
    <dbReference type="FunCoup" id="A0A1Y1US66">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1US66"/>
    <dbReference type="GeneID" id="33559395"/>
    <dbReference type="InParanoid" id="A0A1Y1US66"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="577"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX40870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="995" mass="108867" checksum="27F5AD0A88FE6667" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USB7</accession>
    <name>A0A1Y1USB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_27762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874590.1">
        <property type="nucleotide sequence ID" value="XM_022012360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USB7"/>
    <dbReference type="STRING" id="4999.A0A1Y1USB7"/>
    <dbReference type="GeneID" id="33554168"/>
    <dbReference type="InParanoid" id="A0A1Y1USB7"/>
    <dbReference type="OrthoDB" id="3365519at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="503" mass="54334" checksum="839B29F5E0371AE0" modified="2017-08-30" version="1">MVQLSFSHSANSLSSMNLPIPRSRAPSRAGSDGGSIAPSARNGGPPPKAQERLVEIVMPEPLAAKPQEELVSFAPPTSPKPKLVRKNSRSSIISTSSFGIGRRRANSVNAKDAAALSPSSATLAAPMPGKRELPPVSFPAAKRYTFTRHGDAPSSTRTRTMSGGTSSRPGSIFSVASSPSGTYQPRMSIGPASRPSFAVDRNAPPVPTARSPGGLMAPTPGQNSHRSSFASSDGRSNRVSEFGGYSPVNPKSASPFPNRGEFLSSTPPPRLEQAFERPPPYTIGRAPILRVFVPLSERVRRWPSAEGAAASVKELDKCGATRRLKLGDLVVNTAIKYPKHTEHVLLFVPYIKHLLVPLEYKYSETGHLPSYLDAFSIPPSYYYPFLPTPQIIFLNLAPYCIMAMGAIRLAFDRRDVTTTSGARISAKRYLHVTGFEVCPGDNAAPEWQGMVSLESEGTAEGKMELEQRLGGGDPNRATMGPWEVVREKSMMGTIWLRLIKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USF7</accession>
    <name>A0A1Y1USF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_612658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874630.1">
        <property type="nucleotide sequence ID" value="XM_022014420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USF7"/>
    <dbReference type="STRING" id="4999.A0A1Y1USF7"/>
    <dbReference type="GeneID" id="33556228"/>
    <dbReference type="InParanoid" id="A0A1Y1USF7"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="188"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="329" mass="35921" checksum="D644A50F847DFB72" modified="2017-08-30" version="1">MPSQYVAALVPQINGILRSSDLSTISAKGVRKQLIASGHEESVIKENRTAIDEKIAEIYEKLIANHEPGSPDGPSASGSRPDPSASAGPPSSFPEPLRKAPKVKREVEHEVKEETYAPVRRLEETDEQMAARLQAQFDAEGSSSRASRSAGALRKKSRKVVKRKKGTGDGDSDDAKPKKKRAGGGGGAFNKELVLSDALADFTGEARLSRPQVVKRIWEYVKLHDLQDPADKRFIICDDALKTVFNTDKVHMFTMNKILADHVRDPAEVAFKDEPGQNGPRQEHEPPVLVTSSQTAPVKAEPAAPAQYNSADMSTDSEPELESEDDEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USY7</accession>
    <name>A0A1Y1USY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosine-purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_574543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874807.1">
        <property type="nucleotide sequence ID" value="XM_022013067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USY7"/>
    <dbReference type="STRING" id="4999.A0A1Y1USY7"/>
    <dbReference type="GeneID" id="33554875"/>
    <dbReference type="InParanoid" id="A0A1Y1USY7"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX41128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="517" mass="55605" checksum="F26F13028CB60499" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT68</accession>
    <name>A0A1Y1UT68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_613675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874898.1">
        <property type="nucleotide sequence ID" value="XM_022014527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT68"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT68"/>
    <dbReference type="GeneID" id="33556335"/>
    <dbReference type="InParanoid" id="A0A1Y1UT68"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="338" mass="36840" checksum="EF8DD850C0D6223B" modified="2017-08-30" version="1">MSRNVVLITGGGGWLGNVLAGQLLDDPETPNIHLILADIVEPKPPKEAKNCICVKADLTDPSEMQKLLRTEYGVPDTIYCFHGIMSRGSEDNFDLGLKVNIDSIRYLLDACRNVTTSSGDLIRFIFTSSLAVYGGDLPEIVTPDTIATPEGAYGTGKLVSELLVNEYTRRGLIDGRILRLPTVVVRPGSPSAATSAFISGIIREPLHGQRAICPVGTGPEDDALSLAAWVASPETTVENFVIAKHIPAEKFKRHSRTVYLPGFTTTVKEELDALVEIEGEEALKLLDFKDDPTNRRIVSSWPAKFDNTYPTSLGFIVDEGGMLPIVKRFKEMVQSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTG0</accession>
    <name>A0A1Y1UTG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_648122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874921.1">
        <property type="nucleotide sequence ID" value="XM_022017786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTG0"/>
    <dbReference type="FunCoup" id="A0A1Y1UTG0">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTG0"/>
    <dbReference type="GeneID" id="33559595"/>
    <dbReference type="InParanoid" id="A0A1Y1UTG0"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="851" mass="92341" checksum="4BA5CF93F038415E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5M0</accession>
    <name>A0A1Y1U5M0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_684329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000025">
        <property type="protein sequence ID" value="ORX33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867678.1">
        <property type="nucleotide sequence ID" value="XM_022019214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5M0"/>
    <dbReference type="GeneID" id="33561023"/>
    <dbReference type="InParanoid" id="A0A1Y1U5M0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="25341" checksum="8C9A5C0FFAAE284F" modified="2017-08-30" version="1">MENYAELIKARAENEVLWAAVTRLNNTREKDKDVPNQSVERSSPQERVPWGEEVRLHGRLSLNLFDGGTRSWSDSGEEDEDVTISGPHARMFATMGTIPRRILHNMQDAAESPIRDGESLEGEMDSDDSLPLLRAAISDDEGGVDDDNHTGSDIQFEDDETLNWIPQVESPAPESEDPLHSQNDEGRLSETRSLEDTSHGREDFDWNFTKDDLDFVASLLTDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U611</accession>
    <name>A0A1Y1U611_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_639753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867767.1">
        <property type="nucleotide sequence ID" value="XM_022017281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U611"/>
    <dbReference type="STRING" id="4999.A0A1Y1U611"/>
    <dbReference type="GeneID" id="33559090"/>
    <dbReference type="InParanoid" id="A0A1Y1U611"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="284" mass="31076" checksum="8BB8F83152D6CF2F" modified="2017-08-30" version="1">MPTPLSPSSSQEIISISPPPEASSSRSQKRKFVDPLATTLPRPETFIPRGELKDDIARHIEEQEKRIDIQNGKRRVKREASGSKRVKVEDGVEMSRTQVTNRMMATLGKDDNPITNSDLYSRTDHFVSASTGHQQSNRGGGSSGAATYWAVRTAKMEDQAREKKSDLFKGCVFYLNGSTGPKVSNLQAQHMITANGGRFLAMCNASCTHIIASGGLSGSKTQKWIDGQAGRGASKRTKVVRVDWLLDCVERGRRINEADYGVIKDSSQKSLLGVFSKSSSSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U647</accession>
    <name>A0A1Y1U647_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_639622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867838.1">
        <property type="nucleotide sequence ID" value="XM_022017255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U647"/>
    <dbReference type="GeneID" id="33559064"/>
    <dbReference type="InParanoid" id="A0A1Y1U647"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="233" mass="25790" checksum="742FCE3AC41318E3" modified="2017-08-30" version="1">MPKSFDYVIEHMEEDDEQTKALPRWVELEYAHMLTLIGPSSRLRFTSLSASSIPALRSSLAHHPESGKAHAHTEPIMSLVDTSSSASASASAPASSTDKIAFSRVCLLDPRATKVLAPEDAEIFDCFLYGGILGDDPPRDRTAELRKLGFEGRHLGPKQMTTDTAVGVTKKVVEDGIELDEIPYIDFPTISFNKKESIEMPFRYVSDDKGEPILPPGMKEHLKADLDRTIDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U694</accession>
    <name>A0A1Y1U694_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative aldehyde reductase i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_639291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867879.1">
        <property type="nucleotide sequence ID" value="XM_022017215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U694"/>
    <dbReference type="FunCoup" id="A0A1Y1U694">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U694"/>
    <dbReference type="GeneID" id="33559024"/>
    <dbReference type="InParanoid" id="A0A1Y1U694"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000034">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="329" mass="36915" checksum="6AA05B3B23A4FC50" modified="2017-08-30" version="1">MVPSHFTLSNGKKIPSIGLGTWQSKPGEVKAAVEAALKSGYRHIDCAWGYGNENEVGEGIKASGVPREEIWITSKLFEYHHEPKYVEMALKDTLKKLGVDYLDLYLMHWNICFQVDAPEGELPLKEHLVKNDEGTVKLNVPLSDDVTPTWQALEACVEKGLTKAIGVSNLNINRTKQVLKIAKIKPVANQVELSIQCPQPELVSWLQKNDILPCAYSPLGGTDGQKLRENETVVKIAEKHNVQGATVLISWLLKRGICVLPKSVTPSRIESNLKTVDLSEEDFQAIEKLAESHPPNRVCDQSTLYDPHYDIYQEKSEEFSDKKMWAQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6E3</accession>
    <name>A0A1Y1U6E3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_654063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867929.1">
        <property type="nucleotide sequence ID" value="XM_022018745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6E3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6E3"/>
    <dbReference type="GeneID" id="33560554"/>
    <dbReference type="InParanoid" id="A0A1Y1U6E3"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="115" mass="12750" checksum="AD3A97C31C2F303A" modified="2017-08-30" version="1" fragment="single">QGLRRFIETNRSRLGEAQAFVRNWFEDRGVHVANSNAGNFVWVNLGGALGFDDAVTEKRVFQKLLDGGVYIAPGTAYHNSKAGWYRITFSVARENLEVGLGKIESLLDLKVANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6G6</accession>
    <name>A0A1Y1U6G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_207767</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867941.1">
        <property type="nucleotide sequence ID" value="XM_022012182.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6G6"/>
    <dbReference type="GeneID" id="33553990"/>
    <dbReference type="InParanoid" id="A0A1Y1U6G6"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="12">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="717"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="775"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="949"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="795"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1069"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1300"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1320"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1338" mass="144559" checksum="A93F909CECBA1DCC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6P6</accession>
    <name>A0A1Y1U6P6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_653970</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867982.1">
        <property type="nucleotide sequence ID" value="XM_022018733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6P6"/>
    <dbReference type="FunCoup" id="A0A1Y1U6P6">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6P6"/>
    <dbReference type="GeneID" id="33560542"/>
    <dbReference type="InParanoid" id="A0A1Y1U6P6"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="261"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ORX33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="541" mass="59863" checksum="267144FB69075D64" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6V1</accession>
    <name>A0A1Y1U6V1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPP4R2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_638524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868072.1">
        <property type="nucleotide sequence ID" value="XM_022017124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6V1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6V1"/>
    <dbReference type="GeneID" id="33558933"/>
    <dbReference type="InParanoid" id="A0A1Y1U6V1"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="57967" checksum="9E5AE6DBB231D71D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7D7</accession>
    <name>A0A1Y1U7D7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_605258</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868210.1">
        <property type="nucleotide sequence ID" value="XM_022013998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7D7"/>
    <dbReference type="FunCoup" id="A0A1Y1U7D7">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7D7"/>
    <dbReference type="GeneID" id="33555806"/>
    <dbReference type="InParanoid" id="A0A1Y1U7D7"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="195"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="535"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="535"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="661"/>
            <end position="665"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="706"/>
            <end position="708"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="792"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="874"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="906" mass="98053" checksum="FCF85D5E64CECB85" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7H6</accession>
    <name>A0A1Y1U7H6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA processing-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_639571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867821.1">
        <property type="nucleotide sequence ID" value="XM_022017249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7H6"/>
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            <end position="109"/>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Y4</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Cuniculitremaceae</taxon>
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        </lineage>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
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                <person name="Daum C."/>
                <person name="Northen T.R."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">NRRL Y-17943</strain>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="term" value="P:vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="Pfam" id="PF12783">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1600" mass="175370" checksum="2C2246723698F3BE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8T9</accession>
    <name>A0A1Y1U8T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_635899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868695.1">
        <property type="nucleotide sequence ID" value="XM_022016846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8T9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8T9"/>
    <dbReference type="GeneID" id="33558655"/>
    <dbReference type="InParanoid" id="A0A1Y1U8T9"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="258" mass="28502" checksum="48BBBF06D5DC5C27" modified="2017-08-30" version="1">MSSIASSSKLFTPKRSRDEESPSDVEDIPMDDAARAKQARKDARTIRNRESAQRSRNQRKAHMSYLETRVAELEAENKALRGSTREPSPTLTTVSFSDTVNLASVAPPPRDLDIKPTIEELPTLSSLQAENASLRERIALLENLVKQVVAVSNLGGLDKPADVTVSPSLAPAIPLVIPSSTDLTCHPAAMATSDSLALQRVRPRSPWTHMTLDRLDMVARLFVAVARRNPTWGDKCSPGTMRRAKCRSRRMVRNGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8X8</accession>
    <name>A0A1Y1U8X8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_152685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868735.1">
        <property type="nucleotide sequence ID" value="XM_022012031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8X8"/>
    <dbReference type="GeneID" id="33553839"/>
    <dbReference type="InParanoid" id="A0A1Y1U8X8"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="100"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="262" mass="28982" checksum="48030A5D306B217A" modified="2017-08-30" version="1">MTAHREASFEYLNEHASDSTSSGKSRPYRSDREAHANTPAGEYDFNWCFGRVETLRSSGLDLRPLVPSLYASAFVTGSQDKVLQDMYHVKDIGDVLDYLEWSRQDAGVLMFAIFADPSYVNRTVPPWAIFDQQSDPTASPGCENWAFSGVVGIYRADLEHRTGDIGIFLWAFARGTGISLRASALATRYAMTDPSMGPGLGMNKLRFATAIDNTHSRKLGERLGAHQENPDEGKSTNEWIAFISRSDWESGTEGHITGILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U956</accession>
    <name>A0A1Y1U956_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_584177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868325.1">
        <property type="nucleotide sequence ID" value="XM_022013666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U956"/>
    <dbReference type="FunCoup" id="A0A1Y1U956">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U956"/>
    <dbReference type="GeneID" id="33555474"/>
    <dbReference type="InParanoid" id="A0A1Y1U956"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="111" mass="12259" checksum="79F4D44E71466B71" modified="2017-08-30" version="1">MSSRQAGHEPGPVESAMRDKLNKSFNPSLLEIQNDSSKHSHHAPMKAIGGGSGETHFSLTLVSPQFDGLTSIKRHRMVNNLLKDEFDAGLHALSLKLKTPEEWDKEAGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9H5</accession>
    <name>A0A1Y1U9H5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_636885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868435.1">
        <property type="nucleotide sequence ID" value="XM_022016945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9H5"/>
    <dbReference type="FunCoup" id="A0A1Y1U9H5">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9H5"/>
    <dbReference type="GeneID" id="33558754"/>
    <dbReference type="InParanoid" id="A0A1Y1U9H5"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="243" mass="27173" checksum="7705BC5FE4582D81" modified="2017-08-30" version="1">MLGRPPLLYKPIARHLSSTTYRVTCPLHCLRTMSTKQQAKILSTEEAKVEGIKWLKMERIKWQDEDGKERIWEAANRTTRKGDIDSVHIFTLLHHPSKPVSTILIEQYRPPIGKYVVELPAGLVDEGEDARTAALRELYEETGYGTGKGDDGKVVVESESVILAKDPGMTGANCKVVTVSVKLDENDPEPDQHLDPGEHIIKRIVPLRDLSRTLQDYDQKGFVIDALTSSIVMGYELAGKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9Z9</accession>
    <name>A0A1Y1U9Z9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_653604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868193.1">
        <property type="nucleotide sequence ID" value="XM_022018678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9Z9"/>
    <dbReference type="GeneID" id="33560487"/>
    <dbReference type="InParanoid" id="A0A1Y1U9Z9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="607" mass="66828" checksum="664DF7DD5ED64B02" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA55</accession>
    <name>A0A1Y1UA55_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BD324DRAFT_633156</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869129.1">
        <property type="nucleotide sequence ID" value="XM_022016601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA55"/>
    <dbReference type="FunCoup" id="A0A1Y1UA55">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA55"/>
    <dbReference type="GeneID" id="33558410"/>
    <dbReference type="InParanoid" id="A0A1Y1UA55"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000097">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1031"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1089"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="230"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="893"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="760"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="866"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="870"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="870"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ORX34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1129" mass="124557" checksum="19846C7CDF1C0617" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA57</accession>
    <name>A0A1Y1UA57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_635902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868697.1">
        <property type="nucleotide sequence ID" value="XM_022016847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA57"/>
    <dbReference type="GeneID" id="33558656"/>
    <dbReference type="InParanoid" id="A0A1Y1UA57"/>
    <dbReference type="OrthoDB" id="5577037at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="151" mass="17163" checksum="47EAB722393126F5" modified="2017-08-30" version="1">MVYHTIVKSIAVKNFEAVNTHDYESILKGCAPNIRHRFGGNHALGGTRNDKEALNKWFHRLGRLYPNLKLTVRDVWVKGWPHDTRVFIRWTAADKFADGTPYDNHGVHVIRLCWGKAVEIDANEDSQVVDKWLRAKMAEGVTEAGEPAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA95</accession>
    <name>A0A1Y1UA95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_652670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869164.1">
        <property type="nucleotide sequence ID" value="XM_022018533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA95"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA95"/>
    <dbReference type="GeneID" id="33560342"/>
    <dbReference type="InParanoid" id="A0A1Y1UA95"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19473" checksum="B77407FAAF209076" modified="2017-08-30" version="1">MPTTLYDGTIRNIICSLKSLRNCLQIAQAKHSDPQSLVTARLISDMQPLSYQIYVATRTSDRLAAVMLNKDSLPNHENDLKSFDDFLQRIDQVLSNLEQVRPEEINALDGVPSVANMSRNERENHVPTSASNAFGAAMPHLHFHCDMAYAILRKEGVPLGKADYIQAFADGWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAA2</accession>
    <name>A0A1Y1UAA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_637996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868293.1">
        <property type="nucleotide sequence ID" value="XM_022017066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAA2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAA2"/>
    <dbReference type="GeneID" id="33558875"/>
    <dbReference type="InParanoid" id="A0A1Y1UAA2"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="274" mass="31675" checksum="A9EAF575220157F6" modified="2017-08-30" version="1">MDFLVLHRREHLLFHFYISRAISHPPKRPGSRITQSSAKLNIFNATRRLSTMSSAPEWIELLKKHVDKKDQHTTVYAFSTLSPEGKPRVRHCIHRDITPSNLLLTTTDTRMQKPLQLGEHHQVEIAWWMEPPAVQFRLRGQAFTLPADQNQVSKALKELGVQGEEADAKWWEEKRKSIWANDMSGHLRGSFGRPPPGKPLSEIKEKPEDWPERLDAESDDPEQQKLIDNALSHFALIAFKVEWAEYLELKPSPNRRTQWTKKSDGSWDKVSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAF7</accession>
    <name>A0A1Y1UAF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_583584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868760.1">
        <property type="nucleotide sequence ID" value="XM_022013627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAF7"/>
    <dbReference type="FunCoup" id="A0A1Y1UAF7">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAF7"/>
    <dbReference type="GeneID" id="33555435"/>
    <dbReference type="InParanoid" id="A0A1Y1UAF7"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="116" mass="12390" checksum="6DE9500AB63E1C6B" modified="2017-08-30" version="1">MTVHALWVINKAGGLVFSRSYSDTLPPLPLNTILILAGTLHGIHAITSRLTPAPPPGPVGGLESFEAESWGGRVFLTPTGTKFVVLHSLPHPGLDDLLKRIYETCRACSTCVDISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAN8</accession>
    <name>A0A1Y1UAN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868423.1">
        <property type="nucleotide sequence ID" value="XM_022016938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAN8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAN8"/>
    <dbReference type="GeneID" id="33558747"/>
    <dbReference type="InParanoid" id="A0A1Y1UAN8"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="915" mass="100124" checksum="88ADBBF9816BFBBA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAX8</accession>
    <name>A0A1Y1UAX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_122576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869395.1">
        <property type="nucleotide sequence ID" value="XM_022011961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAX8"/>
    <dbReference type="FunCoup" id="A0A1Y1UAX8">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAX8"/>
    <dbReference type="GeneID" id="33553769"/>
    <dbReference type="InParanoid" id="A0A1Y1UAX8"/>
    <dbReference type="OrthoDB" id="2015992at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="23953" checksum="37EEE273123EDB48" modified="2017-08-30" version="1">MSDIPSLSGNMSVGASKIALRRVMLRKLRDVSQDDLSAQSIAVTSRLLSSPFFKDAQSIGCYLSMAQGELRTDLIVRHILESGKKLYTPYLPNVAKAIGKPTPGSSAVNSEEDHPAPILASMQMLRLYSEEDLSLCPLDKWGIPDPGELRRDCQMKTAREDSMDAAASPIDLILVPGVAFDSLANRLGRGKAFYDRFLRIYVSEKGRPHIGNSSQSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAZ8</accession>
    <name>A0A1Y1UAZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_652983</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868966.1">
        <property type="nucleotide sequence ID" value="XM_022018589.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UAZ8">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAZ8"/>
    <dbReference type="GeneID" id="33560398"/>
    <dbReference type="InParanoid" id="A0A1Y1UAZ8"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1528"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1992"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2250" mass="255508" checksum="B43C34A680D88D51" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB23</accession>
    <name>A0A1Y1UB23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_131575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868986.1">
        <property type="nucleotide sequence ID" value="XM_022011989.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB23"/>
    <dbReference type="GeneID" id="33553797"/>
    <dbReference type="InParanoid" id="A0A1Y1UB23"/>
    <dbReference type="OrthoDB" id="423221at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF26">
        <property type="entry name" value="FAMILY HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="2047"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1544"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1502"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1544"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1564"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2224" mass="246588" checksum="D9C75B255EB16B65" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB66</accession>
    <name>A0A1Y1UB66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869449.1">
        <property type="nucleotide sequence ID" value="XM_022018484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB66"/>
    <dbReference type="GeneID" id="33560293"/>
    <dbReference type="InParanoid" id="A0A1Y1UB66"/>
    <dbReference type="OrthoDB" id="2573023at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="385" mass="41793" checksum="698812DB62AABE6A" modified="2017-08-30" version="1">MDPIIVPSPVNERPALSVLPCLRPATVGSSIPPTIPEDPIQPQLSNAIASSSTLPLEAVPNLPRPLRSCLSPSRRPSICPTPERVPSSRATSFSSDASFENGWRRTKSVRWEGEDQGCAVTSYHSTWSSLEYDRSPLEPPSEAERTCVLPERDSRCLRTKIDCFTSSAILDEFCESPVDERDASRDLIITPLFAEDVSIEDCSSTDVSDTEDREDEEDREWEACMERRRMMFAMRAQELKSEEHQPEFEGYRSLSATLAELLKSVGASDDVAMGPSGGPSVHVLSMQNLEDQEDGSVAEAPTNNLVLLSHPIMPTPSLLSSAGSEDDSVIVTSPSQPTAAQIILAPLSFDADKQAVDPADKALFIASCMVVQDGIMTVAAPSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBI0</accession>
    <name>A0A1Y1UBI0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_643335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869088.1">
        <property type="nucleotide sequence ID" value="XM_022017537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBI0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBI0"/>
    <dbReference type="GeneID" id="33559346"/>
    <dbReference type="InParanoid" id="A0A1Y1UBI0"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012282219" evidence="4">
        <location>
            <begin position="18"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="7">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="345"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="617" mass="68755" checksum="8AE0BEBC4FC62258" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBI2</accession>
    <name>A0A1Y1UBI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_632533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869552.1">
        <property type="nucleotide sequence ID" value="XM_022016528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBI2"/>
    <dbReference type="FunCoup" id="A0A1Y1UBI2">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBI2"/>
    <dbReference type="GeneID" id="33558337"/>
    <dbReference type="InParanoid" id="A0A1Y1UBI2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="206" mass="22555" checksum="98695C064BEEBA46" modified="2017-08-30" version="1">MSHAAEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIDLEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDSDTYNNVKQWLQEIDRYAVEGVNKLLVGNKSDLATKKVVDYAAAKAFADELGIPFLETSAKNATNVEQAFLTMSKQIKDRMGSTSMASGPGGKSTIKGLGQNVEQKASGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBR1</accession>
    <name>A0A1Y1UBR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_609716</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869190.1">
        <property type="nucleotide sequence ID" value="XM_022014169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBR1"/>
    <dbReference type="FunCoup" id="A0A1Y1UBR1">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBR1"/>
    <dbReference type="GeneID" id="33555977"/>
    <dbReference type="InParanoid" id="A0A1Y1UBR1"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="138" mass="14719" checksum="901C11DFC572FFD2" modified="2017-08-30" version="1">MSSKTTGGKGGKAKTSSETKVLTTRSSKAGLQFPVGRIHRFLRSKNANNVRVGAKAAVYVAAIMEYLTAEVLELAGNAAKDLRVKRITPRHLQLAIRGDEELDLLIRATIAGGGVLPHIHKNLITKGSAIAPKKVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBS3</accession>
    <name>A0A1Y1UBS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_633052</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869681.1">
        <property type="nucleotide sequence ID" value="XM_022016589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBS3"/>
    <dbReference type="FunCoup" id="A0A1Y1UBS3">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBS3"/>
    <dbReference type="GeneID" id="33558398"/>
    <dbReference type="InParanoid" id="A0A1Y1UBS3"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="862"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="330"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116529" checksum="A40F56C9CAE6CADC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBT7</accession>
    <name>A0A1Y1UBT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_632946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="ORX35462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="4999.A0A1Y1UBT7"/>
    <dbReference type="GeneID" id="33558385"/>
    <dbReference type="InParanoid" id="A0A1Y1UBT7"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48436" checksum="1004ABF9BEEE3EB0" modified="2017-08-30" version="1">MSDKLKRPEKPLVVLILGGTTTVARTLAGYLLDNDERKASFVRIADRFSVHPPSTYLDRFFLDLLVAPEGSLEYKQVNLVNAERHQEVFTPPTDWKGRTINHKAFDVVYDLTALSLAQSAAGLANKPKAYVRLTFPFYEMKSLSGSSAGHAESAELRPDGVRGRWWHETLRGIGKVQGLNTGVIRSGAFYGPGIWEETVVPRLVVGHVYKSLNEEMKFLHNSDLRIHCVHAIDVAQSLYLLSLYLLSTTREKVILQSGVEIPFSFSNPPTSTFSLGANKRNSVSEIWKTVKSVIPEQIPVTLPLFNVIDDGDTTQEALAKAVAGVWDIKYGFLNSTVASLVQQFAKTDFLEMVEDVNEKHVEAWSNMLAKSSTPIASSPITPYLDEHAFRKHAICLDGSKSRRILGFKPLHPRIEVGELQRIVHGFQEAKLWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBW5</accession>
    <name>A0A1Y1UBW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_633062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869682.1">
        <property type="nucleotide sequence ID" value="XM_022016590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBW5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBW5"/>
    <dbReference type="GeneID" id="33558399"/>
    <dbReference type="InParanoid" id="A0A1Y1UBW5"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="525" mass="56311" checksum="DDE55C20D9A89C5A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC34</accession>
    <name>A0A1Y1UC34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_117647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869310.1">
        <property type="nucleotide sequence ID" value="XM_022011947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC34"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC34"/>
    <dbReference type="GeneID" id="33553755"/>
    <dbReference type="InParanoid" id="A0A1Y1UC34"/>
    <dbReference type="OrthoDB" id="2565173at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="60649" checksum="4658072CAA3F500E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCT0</accession>
    <name>A0A1Y1UCT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_81109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869973.1">
        <property type="nucleotide sequence ID" value="XM_022019252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCT0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCT0"/>
    <dbReference type="GeneID" id="33561061"/>
    <dbReference type="InParanoid" id="A0A1Y1UCT0"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="9">
        <location>
            <begin position="166"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX35809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="425" mass="47716" checksum="A6D043F6760CA9BC" modified="2017-08-30" version="1">MVGSRSPRRTTTLTALAVTCLLVVVLHIWMDPLPFLLPSAWTADAEVPVRAVPGRTGGQVPGFMILDNVWIVDRTFYIPERLDGVSAHMISSDPFKVEIGSMGDPSTADIRLDGLTLLFNEAGFHFMWHYYHFVTEDLLGGLAALAATPRAHRRNLISSNAESDPLPARLAIPWEPGWRDRWGMNNVVVKAMFGANVIDSDQWTTMTAGNKTVFLPQVLIVDRWASQNHNKLAQDWNKMALPVYAQAKPKGFFDPARQKVFKSLGIAKPSDPIPVIVYIDRQSTERRMSQESQYALLALGESMQARGVIRWKHVILEDLTPEQQIEIVSDASVLLGIHGNGMTHLVWMPEGSTVIELFPYDSFIRDYQCVAEVLGFNYFAIQNDSVLLREEWSRHIGELNPKTLHNGTEIPLHVPFLEDILSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD43</accession>
    <name>A0A1Y1UD43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870107.1">
        <property type="nucleotide sequence ID" value="XM_022016248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD43"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD43"/>
    <dbReference type="GeneID" id="33558057"/>
    <dbReference type="InParanoid" id="A0A1Y1UD43"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="580"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="669" mass="74871" checksum="02B15F6B52D8B286" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD94</accession>
    <name>A0A1Y1UD94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_629905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870157.1">
        <property type="nucleotide sequence ID" value="XM_022016271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD94"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD94"/>
    <dbReference type="GeneID" id="33558080"/>
    <dbReference type="InParanoid" id="A0A1Y1UD94"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="102"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="319"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="568" mass="61801" checksum="2D2510942C003798" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDX0</accession>
    <name>A0A1Y1UDX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_631360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869878.1">
        <property type="nucleotide sequence ID" value="XM_022016426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDX0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDX0"/>
    <dbReference type="GeneID" id="33558235"/>
    <dbReference type="InParanoid" id="A0A1Y1UDX0"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="215" mass="23751" checksum="4C8EC07684E19D2F" modified="2017-08-30" version="1">MAVVEDVPDESEIPLKHPSEIRNQSAREPLVELSSGSNLRQRRVQAGADSEDVEHDEEELKAVDANGSALKSIMTGGEDVTPEWFDIGIMTVPFVFLYLLLDILVHLQYQHRPTVEHLTMNLIKAVPTLGVIMYYTTKHSSHFLTNSLLMSASVISGCRLIWLVNMAGWSLTTDQAPAMGTIWILTIVQLPLSRALIALGIVAGWTKYAGMKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDY3</accession>
    <name>A0A1Y1UDY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_631497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869911.1">
        <property type="nucleotide sequence ID" value="XM_022016439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDY3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDY3"/>
    <dbReference type="GeneID" id="33558248"/>
    <dbReference type="InParanoid" id="A0A1Y1UDY3"/>
    <dbReference type="OrthoDB" id="5418639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680:SF1">
        <property type="entry name" value="OS05G0489500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680">
        <property type="entry name" value="OS07G0190500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="229" mass="25958" checksum="50D4F1FB46718622" modified="2017-08-30" version="1">MSRVTTRVNTRTRNEQDDDEEVPKCSGHQRLAKQFVAGPTAKNPGRSFYACPLSRNDPQRCKFFQWADESEKTTVATPGEGHRLGGRQLQTPPQTHEIDWSKVDTDKLEREASASQSSQQAVNTTPLNERLSSLAKRKTDDEDVTPVKRIHLDPQSPFVTSPMHPALSPSTHHLEEVSEHLHRQDRLIKAGQAAKEGLRSQINRLKDRNAELEARVKQLESQIEQMRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEG8</accession>
    <name>A0A1Y1UEG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_628867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870544.1">
        <property type="nucleotide sequence ID" value="XM_022016151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEG8"/>
    <dbReference type="GeneID" id="33557960"/>
    <dbReference type="InParanoid" id="A0A1Y1UEG8"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="351" mass="39573" checksum="5206FD6B74BCC1FB" modified="2017-08-30" version="1">MSICPCCEIQQPAQYCSQCLREGVATHHRLSHSLRAQCASSIVTSSQILTEGSRSLDVWRRIRAEVALAERRVRRLVQKIQSIESELAGDVPDPFRVQRRHQKPTMTDRDVEARHQEIIQRQSDVDHRLVHARRVLVKEAVTVFGLQDGDIPSIAGLPVPLHYDLRKQPSFMMNAAISHVIHLLRMLSIYLSIALPFQPDYPKHFHVGRPIIRANLPFLQTSKYREAYPLWISSTAWKTDLKSRAKHRNFLQTFGLLAHSVSYLAWSQGVQGIGIPDDSIDSVQIPVTSLVRLLRTTADSPSLGHRAHEPGTAFLPHLGFGLDVSRVVAWTSVTESADDGEQTDEWDVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEV8</accession>
    <name>A0A1Y1UEV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_651757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870620.1">
        <property type="nucleotide sequence ID" value="XM_022018390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEV8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEV8"/>
    <dbReference type="GeneID" id="33560199"/>
    <dbReference type="InParanoid" id="A0A1Y1UEV8"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="230"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="38872" checksum="17EA2624AC614549" modified="2017-08-30" version="1">MPRCTRKGCQKEFDESSNEDGSCKYHPGGPVFHEGLKSWSCCNEVNKPVLEFDAFMEIPPCTTGKHSTEAPPKPVATTAPAEPAQGPTKTVNGVETYGQAAPPSSSNGAGSSSKSAPVAALPPAPTPVPAPAQPKETEEDDLSVPVPSGATCKRLGCGATWQGEDISRGSGEQSTCRYHPQSAIFHEGSKGYLCCKRRVLEFSEFLKIEGCTEGNHLFVGAKRDESVEEMVDCRVDFYQTPTQVHVSAFAKGADKSKSTVRFDSQQLHFDFHLPSNKRIAKSLTLYGPIDPASSTFRIVSTKVDITLIKSTPASWPLLELPAEGTELPPGYALTFGVSGRTGTVGGKEIVLAPEEAARRLQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFA5</accession>
    <name>A0A1Y1UFA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_580819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870318.1">
        <property type="nucleotide sequence ID" value="XM_022013466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFA5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFA5"/>
    <dbReference type="GeneID" id="33555274"/>
    <dbReference type="InParanoid" id="A0A1Y1UFA5"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="290" mass="31472" checksum="CB2BE60597F4B556" modified="2017-08-30" version="1" fragment="single">RPQWTRLIRYQNLQGQERYGEPVDPTMDIGLALANAEPIMAPWENGRRLSETEQVHRLLSPISAEMCGLIRAVGLNYVDHAIELKVPIPTVPTLFFKPSHAIAPPNTVIIVPPVAQDEELDFEVELAVIIGRETKDAKETDAMDHVLGYTVANDLTARKHWQSSSQWGFCKGFDGFCPLGPCIVAAHAMDPHQLSLTTHVNGEIMQNGLTSSMIFSISKLVSYLSQGTTLPAGTVIITGTPPGIGDSRSPKVWLRHGDVVECAISGGIGTLINTIEYGSPAKINRGSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFI0</accession>
    <name>A0A1Y1UFI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_627026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870818.1">
        <property type="nucleotide sequence ID" value="XM_022015956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFI0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFI0"/>
    <dbReference type="GeneID" id="33557765"/>
    <dbReference type="InParanoid" id="A0A1Y1UFI0"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="186"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="583"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114977" checksum="9233EF22C53575D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL2</accession>
    <name>A0A1Y1UFL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_682014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869984.1">
        <property type="nucleotide sequence ID" value="XM_022019134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFL2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFL2"/>
    <dbReference type="GeneID" id="33560943"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL2"/>
    <dbReference type="OrthoDB" id="2575493at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="6">
        <location>
            <begin position="578"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="639" mass="71095" checksum="697E27ECCF139D62" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGN8</accession>
    <name>A0A1Y1UGN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_434316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871268.1">
        <property type="nucleotide sequence ID" value="XM_022012774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGN8"/>
    <dbReference type="FunCoup" id="A0A1Y1UGN8">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGN8"/>
    <dbReference type="GeneID" id="33554582"/>
    <dbReference type="InParanoid" id="A0A1Y1UGN8"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="571" mass="62999" checksum="9579508E37DCD22D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGZ8</accession>
    <name>A0A1Y1UGZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_650855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871287.1">
        <property type="nucleotide sequence ID" value="XM_022018219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGZ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGZ8"/>
    <dbReference type="GeneID" id="33560028"/>
    <dbReference type="InParanoid" id="A0A1Y1UGZ8"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="583"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="711" mass="78679" checksum="E100113AB73C9A6A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH38</accession>
    <name>A0A1Y1UH38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_625756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871380.1">
        <property type="nucleotide sequence ID" value="XM_022015835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH38"/>
    <dbReference type="FunCoup" id="A0A1Y1UH38">
        <property type="interactions" value="978"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH38"/>
    <dbReference type="GeneID" id="33557644"/>
    <dbReference type="InParanoid" id="A0A1Y1UH38"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="375" mass="41683" checksum="D470A074A6A5DAE0" modified="2017-08-30" version="1">MLTGVLTAVTRCRVRKSIFSPTSAPVSPNPFIARYKMSSAPATKKLKSTKVIGTHSGTFHCDEALAVYMLRLTDEFRDADVVRTRDPAKLEPLDIVVDVGGVYDPSRHRYDHHQRGFTEVFGHGGFDKIKLSSAGLVYKHFGKQIIAQQLGGVEESDPTVELLWLRLYSGFIESVDAIDNGVNIATGPTNYSVNSDLSSRVKRINPNWNESTTDETYDNLFQKASAVTGDEFMSQLEYYIKAWLPARDIVREAMEKRLEIDPSGAVVRFDKAAPWKDHLFLLEPSLPSAPSQILYVLYPESEAPNSKWRIQCVPVNPDSFENRKSLPEAWRGVRDQDLSKVSGIDGCVFCHASGFTAGAETYEGVLEMAKKAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH43</accession>
    <name>A0A1Y1UH43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_681266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871408.1">
        <property type="nucleotide sequence ID" value="XM_022019112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH43"/>
    <dbReference type="GeneID" id="33560921"/>
    <dbReference type="InParanoid" id="A0A1Y1UH43"/>
    <dbReference type="OrthoDB" id="5106716at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="434" mass="47458" checksum="5612F0565FB78010" modified="2017-08-30" version="1">MPSLLSKILHKKSPSKDSGADHSTVDDEDPFVSVDSGSPSMTSSRSRSISMDEAPITPRSGSESGTVSTSPHSPVFHRRQGDGPEFVSPSRSAPPPPLPPKDDDRGNLATVTPFSGLPPGAEPARLTRPADVLIVPSAGTQAVSLGTSSTSGIRPLDSIIPGPSSSPLGNLEERMQRVGLDDNVYMDQSVIPKAATITTFSPHRQPLEESRRSLVESIIKETQERKAAKGDLTDEAREIFRRAGLEESLLKTNTVDIKTKWLEPVIQEHIIPRERHEYITIIDRHIHRHHVYPKIQPIEDPDPIILETRHRIFSPKTGHWHEVIGDDAARAILGEDVFTNGPKEVRMKRARALPEIYAAVTAAPSEDETSIVPRRLPALFSGSEEDLTEAGFGTGGRGAVEREGLKGENLGQWRRVQPGILFGQKENDHVAMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH57</accession>
    <name>A0A1Y1UH57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_446614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871428.1">
        <property type="nucleotide sequence ID" value="XM_022012802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH57"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH57"/>
    <dbReference type="GeneID" id="33554610"/>
    <dbReference type="InParanoid" id="A0A1Y1UH57"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="684" mass="76070" checksum="F159237DFF7D1514" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI31</accession>
    <name>A0A1Y1UI31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871710.1">
        <property type="nucleotide sequence ID" value="XM_022015539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI31"/>
    <dbReference type="FunCoup" id="A0A1Y1UI31">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI31"/>
    <dbReference type="GeneID" id="33557348"/>
    <dbReference type="InParanoid" id="A0A1Y1UI31"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="331" mass="38071" checksum="CFAB0106AB430D2B" modified="2017-08-30" version="1">MNFFGRTKARGPADSIKSLREHVARLDQTSSADSKRRINEEISRLLSSTKQALAGEGDADAGGDVLAQVANEVYASDILNLMVVNLGKFEFEARKDSCHIFNTLLRRQIGSRLPTVEYITNRPDIVLNTLKCYSNPDIALNSGMILKEMLRYEPLAKILLYSDDFYTFPQYIENSTFGISCDAFANMKETLTKHKPMVATYLDANYDKFFAMYTNLILSANYVTKRQSLKLLGEILLDRANYNIMTRYISAESNLKMMMNFLRDKSRNIQFEAFHVFKVFVANPNKPPQIASILRRNKDKLLIFLKEFHNDKDDEQFNDEKQFLIAQIQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI78</accession>
    <name>A0A1Y1UI78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_672485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871709.1">
        <property type="nucleotide sequence ID" value="XM_022018938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI78"/>
    <dbReference type="FunCoup" id="A0A1Y1UI78">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI78"/>
    <dbReference type="GeneID" id="33560747"/>
    <dbReference type="InParanoid" id="A0A1Y1UI78"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="133"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="227" mass="25683" checksum="2531A2AA80C12707" modified="2017-08-30" version="1">MDNSPTALFENYDEDLKHLLSNLKSKLEGDVKLLKGEERKAALKRVTEELDEAQETVAQMEVELPSMPVSIRQVYQGRLATSKQALEKVKKSLKDVRQENQRNELFAGFPDRDDPYTDDPSGFSSRTRLLQGTERLADGSKRLDNAHRIALETEDVGADILRNLRGQREQLENTRDSLTQADSSIDRAAGTLKKMIFKMYQQKFVTGGIIAILVLLIIIVLWSKIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIA2</accession>
    <name>A0A1Y1UIA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_623111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871729.1">
        <property type="nucleotide sequence ID" value="XM_022015551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIA2"/>
    <dbReference type="FunCoup" id="A0A1Y1UIA2">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIA2"/>
    <dbReference type="GeneID" id="33557360"/>
    <dbReference type="InParanoid" id="A0A1Y1UIA2"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="213" mass="24052" checksum="0F738FF273E51C4C" modified="2017-08-30" version="1">MENQATFKMVLCGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLTFHTNFGTICFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVSTKGVTFHRKKNIQYYEISAKSNYNFEKPFLWLARKLVGNQSLEFVAAPALAPPEVQVDPALIAQYENELKQAANAPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIP1</accession>
    <name>A0A1Y1UIP1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871404.1">
        <property type="nucleotide sequence ID" value="XM_022018239.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIP1"/>
    <dbReference type="GeneID" id="33560048"/>
    <dbReference type="InParanoid" id="A0A1Y1UIP1"/>
    <dbReference type="OrthoDB" id="2597039at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1432" mass="157456" checksum="ED819300B911764E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ47</accession>
    <name>A0A1Y1UJ47_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_624432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872067.1">
        <property type="nucleotide sequence ID" value="XM_022015701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ47"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ47"/>
    <dbReference type="GeneID" id="33557510"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ47"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="634" mass="70040" checksum="340A817C2956800B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJF5</accession>
    <name>A0A1Y1UJF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_436207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871293.1">
        <property type="nucleotide sequence ID" value="XM_022012781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJF5"/>
    <dbReference type="FunCoup" id="A0A1Y1UJF5">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJF5"/>
    <dbReference type="GeneID" id="33554589"/>
    <dbReference type="InParanoid" id="A0A1Y1UJF5"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="87" mass="9498" checksum="D5D477A171BA599F" modified="2017-08-30" version="1">MENDKGALVDLYIPRHCSATNRLITAKDHASIQIQIADVDADGKAIKGKSTTIAICGRVRAQGDSDDSINRIAQKDGLLKNVWTYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJI6</accession>
    <name>A0A1Y1UJI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_577481</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872135.1">
        <property type="nucleotide sequence ID" value="XM_022013262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJI6"/>
    <dbReference type="FunCoup" id="A0A1Y1UJI6">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJI6"/>
    <dbReference type="GeneID" id="33555070"/>
    <dbReference type="InParanoid" id="A0A1Y1UJI6"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="923"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1069" mass="117503" checksum="58985C4B69A2128D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJJ5</accession>
    <name>A0A1Y1UJJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_622961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871694.1">
        <property type="nucleotide sequence ID" value="XM_022015532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJJ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJJ5"/>
    <dbReference type="GeneID" id="33557341"/>
    <dbReference type="InParanoid" id="A0A1Y1UJJ5"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="142"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="547" mass="59512" checksum="6F1A945F8F15A9C2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJM0</accession>
    <name>A0A1Y1UJM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872170.1">
        <property type="nucleotide sequence ID" value="XM_022015249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJM0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJM0"/>
    <dbReference type="GeneID" id="33557057"/>
    <dbReference type="InParanoid" id="A0A1Y1UJM0"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="143" mass="15972" checksum="E96A7D2A20B9586A" modified="2017-08-30" version="1">MNDGTSTIKLQTYASHLNTVLLPSLDQLRRNLAKLEQDIAEYDDVSQKAKLLVADARRPQEAMMDLGAGVYVDVIVPDTSQMTLDLGLDIHLQMPVDEAGEYAAKRVTMLQKRRSALKIKEENLIWQIEQFRGAMNQASGLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK26</accession>
    <name>A0A1Y1UK26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_403013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871841.1">
        <property type="nucleotide sequence ID" value="XM_022012692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK26"/>
    <dbReference type="GeneID" id="33554500"/>
    <dbReference type="InParanoid" id="A0A1Y1UK26"/>
    <dbReference type="OrthoDB" id="2573607at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="332" mass="35418" checksum="B375CAC3C7162289" modified="2017-08-30" version="1">MPHTHPSPKLGQGYASSRPSIHNRLQSGPGQAAQSSQRPHAPRHTLSTSTTSSSRYLSPIQEQRILSWRDNTVPSKPADSPRMTTTTTTPKIKSAPASLAYSKSTPTGSSVYSKCPLCAGASSCSCSPYEQSATGAHQPRRQKSYYKNSKTKRGTTPSRTAVSPLTPSTPASSPHPQSAKTAHRQMSTDTGYSDSIRYTPDHVKGRLASHYASEQGTSDFRTLPPAPPTYSFSRPNKNGMPSPEQVKAYSSGSAPTAQYGPPPTVPLPEPQVVPPPAGPAMQPQLPRIAGVRDPVSQNYFRNMFPPAAGPFGLQPGLHPPQLFGMPAGRPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKI5</accession>
    <name>A0A1Y1UKI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_563704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872483.1">
        <property type="nucleotide sequence ID" value="XM_022013027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKI5"/>
    <dbReference type="FunCoup" id="A0A1Y1UKI5">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKI5"/>
    <dbReference type="GeneID" id="33554835"/>
    <dbReference type="InParanoid" id="A0A1Y1UKI5"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="100" mass="10824" checksum="EAA8DF364A6A5812" modified="2017-08-30" version="1" fragment="single">TPSAIDHLRSLIASPTEPKLLRIGVKSRGCAGMAYHLDYVSPPGGKFDEVVEQDGVRVLIDSKALFSIIGSRMDWRDNRLSAGFVFDNPNVVDTCGCGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKP9</accession>
    <name>A0A1Y1UKP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_564653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871702.1">
        <property type="nucleotide sequence ID" value="XM_022013030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UKP9">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKP9"/>
    <dbReference type="GeneID" id="33554838"/>
    <dbReference type="InParanoid" id="A0A1Y1UKP9"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18268" checksum="ADBB39A38F44C274" modified="2017-08-30" version="1" fragment="single">HPFDSYAFVQSLKSASFKQAPAEAVMEAVRSLVVERGDQAASRMLSQEDRENQSYLFRAALAELRTELSVRARNDSLALKAASGAIRREVDQLEQKMKEDVETLRHDIELDTNNRKAETRAELKGFNLDIEEINNKFTISLGDLRTEIEAAKWEQTRRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKV2</accession>
    <name>A0A1Y1UKV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_621538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872524.1">
        <property type="nucleotide sequence ID" value="XM_022015392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKV2"/>
    <dbReference type="GeneID" id="33557201"/>
    <dbReference type="InParanoid" id="A0A1Y1UKV2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892161" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="13887" checksum="51E398385AD92EDD" modified="2017-08-30" version="1">MISISNALILLLGSFATVALAHENCTLAVGNMVSEENYGGILVNGVNYIYVVKPDCVYDGTEFDLYIEAIDAKPHCSIAGTLTGGLHHAIYIFNRADYLGGQTGEHYGLTVTCGAPDYAGPPSVGSGRNDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL13</accession>
    <name>A0A1Y1UL13_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_344210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872159.1">
        <property type="nucleotide sequence ID" value="XM_022012533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL13"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL13"/>
    <dbReference type="GeneID" id="33554341"/>
    <dbReference type="InParanoid" id="A0A1Y1UL13"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="120" mass="14128" checksum="85260E46A650CA2A" modified="2017-08-30" version="1">MNGRVVEELNKRFPRYSFYNLWPGLINTPTFTYDWAPFPFDWVMWLGMFIIGSTRDIFAPVPIYIGLCEPDERKRMLGDGQAWKYNMGPSKPGSWATNAINRYSPQYEHCFRLSHSSSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL20</accession>
    <name>A0A1Y1UL20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_577550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872169.1">
        <property type="nucleotide sequence ID" value="XM_022013266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL20"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL20"/>
    <dbReference type="GeneID" id="33555074"/>
    <dbReference type="InParanoid" id="A0A1Y1UL20"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="4">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="239" mass="26387" checksum="26FF42F615B334FF" modified="2017-08-30" version="1">MAKDERHSSASGSSSASSSSSSASSSSSSSSSSSTSTYSAKPLPTSSQPVNNWLEQPDPRTPHTRARIPIHKSLGDYPLIDIDPHVGRVIRYMRASDWAGMLGMTTLAPFLYLSYNRWDTTSRFEVKTVRSAIRVNALFGFFVGFSLAYMESSKRFWGASENSREVKKDFAELSNRAQKGLPIYGSSSLSPYMQAVAARNSTFSQFMMVALPWFNVVNHPYHGVETAKYYRGVASTQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULP3</accession>
    <name>A0A1Y1ULP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_617840</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872765.1">
        <property type="nucleotide sequence ID" value="XM_022014951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULP3"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULP3"/>
    <dbReference type="GeneID" id="33556759"/>
    <dbReference type="InParanoid" id="A0A1Y1ULP3"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="17">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="16">
        <location>
            <begin position="204"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX38902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="469" mass="53046" checksum="E4A841B08CEE7590" modified="2017-08-30" version="1">MSFRSGSIGLLRAASSRICTVQCGHTQVFGPTARLYTTRSSLSVPSSRASAGRSGSMTAISLERRHYASKRDNYPPKVSLKNNVVDVEHRGRSLKLSAAYLLDHCRCSKCSHAKTKQRLKTLSEVDPNVFISELTPSSDGITVQWHGQDGHTALFPWRFWARLVEAQSPQISSKILWDNKIASKPPSIDYERLMPSSAGEEEAEKAVLEWISKVDQYGFCFVNGVPATPEATEELINRIGTIRQTHYGGFWDFTADMSLGDLAYSSQQLPAHTDSTYFTDPSGLQIFHLLSHPPPGEGGHTLLVDGFKAALQLEHDQPGMYQTLSTVPVPHHASGNQGLMYRTCRPVLTVTHEEGDESLEMVRWNNEDRGVLVDRDGWDEESTVEVWYEAAREFERILRSRENEYWVKLQPGTVCVIDNWRVLHGRSSFTGSRRMCGAYVGRDDWRSRLWTLQRRFSNTQKDDLWDFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULS2</accession>
    <name>A0A1Y1ULS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_303499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872863.1">
        <property type="nucleotide sequence ID" value="XM_022012434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULS2"/>
    <dbReference type="GeneID" id="33554242"/>
    <dbReference type="InParanoid" id="A0A1Y1ULS2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="361" mass="40889" checksum="6DA046994E35268A" modified="2017-08-30" version="1">MLQPGDIWYIVGAGSFCGLVLIILIIVWIRVWVKSRAKSRRLQEPNPANERTLDNLHSPLMQNATMPGMAKRLSYEEKDPYAYNDQSQVQPSLTYDQSEQKPAYYYEHPNLSNPELFGQPMVPADQQNHMAVVDHQSYSQHSHNPYASPYDAPLPSSSHDHSSYEYDYNSSQDHHHPAQLAVDPQHQQPYFSPTEYATPDSYHSPGSDYHLMTPQYPDPGMRRIESPASSVSDPYTAMPSGVTSGRTSVHPAYPPPARSPVKSPRGARAELNDTPNSQKRFMERYGRHPPVPDRPHGLTHYASGMQSQEDYDGRDDYRDDYRASSSNDHSSRLHVVNDPYLYGIPSSEGPTNPYSPRRLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULU3</accession>
    <name>A0A1Y1ULU3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_649067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872832.1">
        <property type="nucleotide sequence ID" value="XM_022017931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULU3"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULU3"/>
    <dbReference type="GeneID" id="33559740"/>
    <dbReference type="InParanoid" id="A0A1Y1ULU3"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX38969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="440" mass="47240" checksum="750F8D68C0F5D753" modified="2017-08-30" version="1">MPSPDLSLYHGSTPLANKVAGHQNVMSDESGSLVIKPALPREIAFYHMLGSAPRSSALAQLKPFVAQFYGTLRLEGQLDGLGGISKEGIKVGEVPESIVLENLAHNYTRPCVLDAKLGTELHAPDASEEKRARMEKQARETTSHATGLRLTGCQIWHAPTSSYILTPKSYGKSLTPSSLPAGIIRFFPLPTDKLASLVLPLSPSSDNASTPSTGGGVSHLPLTPADPASLEKLTAPGPSGSSEKVPGPDSPTEPVEYTSHAIPPALLLRLLSAIDGKMAELEHVISRLEARFIGASALLVYEGDPERLEDALNRYDERQKALSVAAQGRGPGQSVKDADLEGDDEEEEEEEEEEDDELEDDYDSSTSSDDDSQDGQRADARRARRCPPFTLKMIDFAHTRLVQGEGRDEGVLLGLRTLRGLIQGRIGQVNADMGRQGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM35</accession>
    <name>A0A1Y1UM35_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucosamine-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucosamine acetylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoglucosamine transacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_618344</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872915.1">
        <property type="nucleotide sequence ID" value="XM_022015017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM35"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM35"/>
    <dbReference type="GeneID" id="33556825"/>
    <dbReference type="InParanoid" id="A0A1Y1UM35"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000105">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rho-GAP" evidence="11">
        <location>
            <begin position="497"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="797"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="696"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1095" mass="119965" checksum="CBDBA62A3823AFCA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM46</accession>
    <name>A0A1Y1UM46_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_576598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872984.1">
        <property type="nucleotide sequence ID" value="XM_022013198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM46"/>
    <dbReference type="STRING" id="4999.A0A1Y1UM46"/>
    <dbReference type="GeneID" id="33555006"/>
    <dbReference type="InParanoid" id="A0A1Y1UM46"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="29"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1037" mass="112580" checksum="D7DA0D47948CF331" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMB2</accession>
    <name>A0A1Y1UMB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_576769</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873056.1">
        <property type="nucleotide sequence ID" value="XM_022013212.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UMB2">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMB2"/>
    <dbReference type="GeneID" id="33555020"/>
    <dbReference type="InParanoid" id="A0A1Y1UMB2"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000002">
        <property type="entry name" value="cytoplasmic dynein 1 heavy chain 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="12 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="1830"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2460"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="2802"/>
            <end position="2968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="3078"/>
            <end position="3126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="3303"/>
            <end position="3337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX39193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="4468" mass="505479" checksum="1C84E54FD98781EA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMJ0</accession>
    <name>A0A1Y1UMJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme oxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_322560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873136.1">
        <property type="nucleotide sequence ID" value="XM_022012483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMJ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMJ0"/>
    <dbReference type="GeneID" id="33554291"/>
    <dbReference type="InParanoid" id="A0A1Y1UMJ0"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="95035" checksum="8A8820B9CF79EFAE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNE7</accession>
    <name>A0A1Y1UNE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_221233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873358.1">
        <property type="nucleotide sequence ID" value="XM_022012212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNE7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNE7"/>
    <dbReference type="GeneID" id="33554020"/>
    <dbReference type="InParanoid" id="A0A1Y1UNE7"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="429" mass="47606" checksum="73CBFD9CF9C4D4D1" modified="2017-08-30" version="1">MTHQTSRLSESSKQRLDELLQDKIHQGTLPCIFWAATNAQETIYENQAGLRIMGDETSGQVTPETTLELYSMTKFVVALAVLQLVDAGQLNLDDEDIVYRILPELGDQKVLQGYDENDDAILLPQAARITPRMLLNHTAGCTTPQRNAMLAKWYAKQGHQAPDGLSTKASVRSLIAPLLHQPGSTWMYSSGTDWLSILIHRMTGLTLEEYFRNQIFDLVPGKMPDTTFYPRPDIVERKAAIYLRLDNGDLKKYPNFSNDRPNTVETVSKEFLAGSGGLFGTTRDFLALCRAVLQCDPSNLSPPARPLISPASFKLLFAPSLTTDSAKAEAVKYYRWEGRWSPDPTVENMTHSLGLAVNLCDSDHGRRAGSGGWYGMARTHFWIDPASGLAAVCSTQVIGPEPDPWNGVFNAFERTLYSELESNGEATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNI1</accession>
    <name>A0A1Y1UNI1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_306077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872907.1">
        <property type="nucleotide sequence ID" value="XM_022012444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNI1"/>
    <dbReference type="GeneID" id="33554252"/>
    <dbReference type="InParanoid" id="A0A1Y1UNI1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="282" mass="32522" checksum="89C8369D5CBF647F" modified="2017-08-30" version="1">MFLVRDLLYETIYDELKSDAMERAEDPLMPPPPPPSPDSYPYNQHFFYADDQLVLNKVFTMTPSSRRLIKALLDHRSFTNKPYELLTEINRRGLNSLARYEELKQRRSDTAVDAAAGRDTKITGAADHVSRTLETLQESMATQTRLNAERELRNDQNMALMMLANSESTQTMEKKNRAQRAVDRADQNVERCEDQIQATEEKMELLEDQIEEAMEMGQEGKVRRLEQRLVKQAESLTALRGRKRKRSGLDIPLRRWTLSLRTIDVSHTLNPSVSQAVYMAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNM0</accession>
    <name>A0A1Y1UNM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_648233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873377.1">
        <property type="nucleotide sequence ID" value="XM_022017805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNM0"/>
    <dbReference type="FunCoup" id="A0A1Y1UNM0">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNM0"/>
    <dbReference type="GeneID" id="33559614"/>
    <dbReference type="InParanoid" id="A0A1Y1UNM0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX39592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="655" mass="70132" checksum="1A4022F352752B71" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNX4</accession>
    <name>A0A1Y1UNX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_614721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873504.1">
        <property type="nucleotide sequence ID" value="XM_022014635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNX4"/>
    <dbReference type="FunCoup" id="A0A1Y1UNX4">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNX4"/>
    <dbReference type="GeneID" id="33556443"/>
    <dbReference type="InParanoid" id="A0A1Y1UNX4"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="59"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="460" mass="49941" checksum="E7E1C79185AE504D" modified="2017-08-30" version="1">MLRSPTRTALRMASSSAIRRTATRGICRSSQAPLSHALLALIPRPLFRASFHSSAIFLDEVVKVPQMAESITEGTLKQWSKAVGDFVKQDEEIATIETDKIDVSVNAPKSGKITELLVEEDSTVTVGQDLFKIEPGEDSGDSEPKAAPEGGARSEPKNPEEGNKDDAAPAANKEKGAGEVKESKPDQPKKEEKPAQEKVKEEKPAPPKQEKAPAKKEDKAPKTAGTRGETRVKMSRMRQTIAQRLKASQNAAASLTTFNEIDMSSIMEFRKLYKDGILKADGVKLGFMSAFARASCLALKEIPVANASIEGDSIVYRDYVDISVAVATPKGLVTPVVRNAEEMGLIDLEKAIAELGKRARDGALGIEDMSGGSFTISNGGVFGSLFGTPIINLPQAAVLGMHTIKERPVVVNGKIEIRPMMYVCLTYDHRLLDGREATTFLVRVKEYIEDPRRMLLPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP08</accession>
    <name>A0A1Y1UP08_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873140.1">
        <property type="nucleotide sequence ID" value="XM_022015121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP08"/>
    <dbReference type="GeneID" id="33556929"/>
    <dbReference type="InParanoid" id="A0A1Y1UP08"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="104" mass="11634" checksum="3BC53A63F0F6E577" modified="2017-08-30" version="1">MLIAGSGTLSVVGNSKSHTESRDSLHDLRKREVSPKTSGEDSTRPKVLDRRARQSSWKSSAGAVCQGETRSRREQGWRYCHTNARDNLHHLGHANDKLGKRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP10</accession>
    <name>A0A1Y1UP10_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_641364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873069.1">
        <property type="nucleotide sequence ID" value="XM_022017418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP10"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP10"/>
    <dbReference type="GeneID" id="33559227"/>
    <dbReference type="InParanoid" id="A0A1Y1UP10"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="372" mass="41808" checksum="8AA454BE5B9D70CF" modified="2017-08-30" version="1">MDGLLAEINNKRKTLEVDVGESSADGARKYMRRAEVEAAREAEARRKREEAAKAKENAKSANRAARMREEKASLARLASPGSGRDTPNARDSPAPGTEKEGFNISPEEAVRRLRAKGQPIRLFGETDKDRRLRLRALELLEERGEHPGLNDFRKTFADLESAADEKEAGRLARESHRKAQDGGKEDEAPVEEKKSKSERVDVGVLDLSLVKTDPNKLYPIIYHAIKNVLKEWEEWMDARPDEVKQTMQGKLAAATQVSSAQNLKPLFRQLRSRDMAADVLRNLSEIVHFMQTRQYSKANDAYLRMSIGNAAWPIGVTSVGIHERSAREKIGQDNIAHVLNDEVSRKWIQAIKRLLTFSQTVRPPDLAAQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP11</accession>
    <name>A0A1Y1UP11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_606986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873517.1">
        <property type="nucleotide sequence ID" value="XM_022014041.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP11"/>
    <dbReference type="GeneID" id="33555849"/>
    <dbReference type="InParanoid" id="A0A1Y1UP11"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="457"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1394" mass="151840" checksum="AC24D51FEA1A10D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP32</accession>
    <name>A0A1Y1UP32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_649384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873170.1">
        <property type="nucleotide sequence ID" value="XM_022017981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP32"/>
    <dbReference type="FunCoup" id="A0A1Y1UP32">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP32"/>
    <dbReference type="GeneID" id="33559790"/>
    <dbReference type="InParanoid" id="A0A1Y1UP32"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="30"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="315" mass="35094" checksum="7F070A41C4903DC9" modified="2017-08-30" version="1">MSMLRTIKPKNARVKRALEKREPQIEEGDKTAIFVRGNSTSERVRLAMQDLYALKRPHAISFSRKNDIHPFEDASSLEFFSGKNDASLFLTGLHSKKRPHDLIFTRMFDGKVLDMIELGIEEIKSIKEFESPKSSVGARPLVVFHSDLFDTHPTYQLLKSILLDFFGGKAVSEVPVTAVEHVISITAGPLASSSSASDSASLPHVHFRVYTMKALPSGGGKPRAELVEMGPSLDLSVRRVQEANEDTWKMATKRPKVAKKDVEKGLGKKRKNIETDEMGDKVGRIHLEKQDLGKLQSRKVKAFKTGKGSAKVQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP54</accession>
    <name>A0A1Y1UP54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_615080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873596.1">
        <property type="nucleotide sequence ID" value="XM_022014680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP54"/>
    <dbReference type="FunCoup" id="A0A1Y1UP54">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP54"/>
    <dbReference type="GeneID" id="33556488"/>
    <dbReference type="InParanoid" id="A0A1Y1UP54"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="407"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="695" mass="75996" checksum="EBE69CE7495B7506" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP65</accession>
    <name>A0A1Y1UP65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_615122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873608.1">
        <property type="nucleotide sequence ID" value="XM_022014685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP65"/>
    <dbReference type="FunCoup" id="A0A1Y1UP65">
        <property type="interactions" value="755"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UP65"/>
    <dbReference type="GeneID" id="33556493"/>
    <dbReference type="InParanoid" id="A0A1Y1UP65"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="194"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="396"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="7">
        <location>
            <begin position="567"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="772"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="103405" checksum="C502FFEFBF363E13" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPT7</accession>
    <name>A0A1Y1UPT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_618673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873018.1">
        <property type="nucleotide sequence ID" value="XM_022015063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPT7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPT7"/>
    <dbReference type="GeneID" id="33556871"/>
    <dbReference type="InParanoid" id="A0A1Y1UPT7"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="378"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="800" mass="89446" checksum="7572A59C5F7F3D80" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ17</accession>
    <name>A0A1Y1UQ17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_616252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873884.1">
        <property type="nucleotide sequence ID" value="XM_022014814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ17"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ17">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ17"/>
    <dbReference type="GeneID" id="33556622"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ17"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="237" mass="27151" checksum="E76DCB31D126C284" modified="2017-08-30" version="1">MKLNVANPATGAQKLFDFDDERKVRCFMEQRMGQDIAVDSLGDEWKGYVLRITGGNDKQGFPMKQGVLLQHRTKLLLSKGHSCYRPRRTGERKRKSVRGCIVGNDIGVLATIIVKQGEQELPGLTDVTLPKRLGPKRATRIRKFFNLDKKDDVRAFVIKREVTRASGKTYTKSPKIQRLVTPMRLQRKRHLQSLKKRRTEAQKESIAEYKAKVAQRAEEKKTHIASLRAQKKARRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ22</accession>
    <name>A0A1Y1UQ22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_648197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873341.1">
        <property type="nucleotide sequence ID" value="XM_022017803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ22"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ22"/>
    <dbReference type="GeneID" id="33559612"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ22"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="70063" checksum="5DD0E34FB2B9AF9E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQH0</accession>
    <name>A0A1Y1UQH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873997.1">
        <property type="nucleotide sequence ID" value="XM_022017890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQH0"/>
    <dbReference type="FunCoup" id="A0A1Y1UQH0">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="GeneID" id="33559699"/>
    <dbReference type="InParanoid" id="A0A1Y1UQH0"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="142" mass="15402" checksum="302302E68D9C6ECA" modified="2017-08-30" version="1">MASEHTTAHQNHQLGGYKAALHNDRVCPSTPSPPHDEQMAYYPLSQVSADAKGHAAEVIVESGKQLPSELDAQSHRHFHNEHPHEIVNANPLGLPQGDPSLDLKAAQEHEHHVRGGYKAALHNPNTSEEAKEQARQALAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQV1</accession>
    <name>A0A1Y1UQV1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_615241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873639.1">
        <property type="nucleotide sequence ID" value="XM_022014700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQV1"/>
    <dbReference type="FunCoup" id="A0A1Y1UQV1">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQV1"/>
    <dbReference type="GeneID" id="33556508"/>
    <dbReference type="InParanoid" id="A0A1Y1UQV1"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="331" mass="34535" checksum="639CD8D61CC1040B" modified="2017-08-30" version="1">MAPSAQSVAQATGVAPLTPNFTAKDYGIFFMSGALCATVTHAGFTPVDVVKTRIQIDPAFKGQGFLTVGRGIIAAEGPAGLLTGFGPTAAGYFFQGGAKFAGYEASKKYLVEMVGSREAAVENRTAIYLGGATIAEFFADILLTPLEATRIRLVSNPKYATGLVSGLTKIASTEGIGGLYAGFIPILFKQVPFAVGQFAVNERCTEFLYNRLDPETRKNLSATATMGITLTSGITAGVAAAILSHPADTLLSQINRGHGPKGSMLYRLGALAKEVGFRGIWSGLGPRMAMTAGLVSSQFVIYGYIKSALGARPGIEIHKENSDAPEGGAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR26</accession>
    <name>A0A1Y1UR26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_606414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874180.1">
        <property type="nucleotide sequence ID" value="XM_022014013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR26"/>
    <dbReference type="GeneID" id="33555821"/>
    <dbReference type="InParanoid" id="A0A1Y1UR26"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="408" mass="45366" checksum="CEF73B6AA9CBDE1E" modified="2017-08-30" version="1">MARTERRRRERDMVARLRGDQATDKRSQRRAEIKCMASYTPTPSEKEAKDKCSKDKRSKDKRSRDGSLMPTSSSSSSSISSSNSTDRGSTTNRPRRRKKTKKDSHSREESREEETPGLRHLDESHVSRSSSPVIPLPATPGREPSPELDVVDGLVSLGEDAMDRVEDDVAPKKDKKGKGKALAQPLRRGKRRLEDIAPVLPVSSQTRSKSVSLATPKKSSDVKTAKRATTSSPVKRGRSVKPSVTPLRALEESGNAGPSSVKRRRMSTKKYPRTPTPASPAKSLPRHKSPDATPASLEAKFAAYCHPVPAERACRQCKSRGLPCWWRNTMGKKKACETCGTRPGCEPWVDPSTLTPTAVIIDTRDKMERLDRVIADSYPDDQSEARLLVSQVKDTLRRLMLKEYGDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR32</accession>
    <name>A0A1Y1UR32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_616015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873822.1">
        <property type="nucleotide sequence ID" value="XM_022014782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR32"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR32"/>
    <dbReference type="GeneID" id="33556590"/>
    <dbReference type="InParanoid" id="A0A1Y1UR32"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="2">
        <location>
            <begin position="284"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="447" mass="50535" checksum="940C01D86A40C4E5" modified="2017-08-30" version="1">MSHTPTGQPGNAPLPPNSTTATATQDKKPTLTGVRIKQRKGQAKATAKFEPEAFRDALLLHLALLPSPLTTDALVAKLVQAGSTLEFLKYYEQLFELLFVGGLLQPGGSYLDDKRSPVYILKDVNDGESATGDDSWKDSVKGVVETLKKVIQRYKYLQKPLEENFLPDLFGYLPKWDPAQRAKLAEATALLILDLQISPRCLSSLTKEHVVKDEVALDFLTAFSRHYLARQNVEHLGLTLRRSGLKDILLVFPFQTRDRKHLEDHFKKENLPQVNEWYAKLAMGEAKDETVLNIERMITEEEGNEQIIEYLKTQKSDNSANDAQITEWIWQALMKTVDWTARPDQIDQTVVQHVQAHAPIIEAFCNGAKAEVGLINAVQVYCYTDTRIIKSFPSILKVLYNTDCISDQAIIYWHQKGAKPQGKQHFLKATEGLVKFLEEQDDSEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR97</accession>
    <name>A0A1Y1UR97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_648300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873450.1">
        <property type="nucleotide sequence ID" value="XM_022017819.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR97"/>
    <dbReference type="GeneID" id="33559628"/>
    <dbReference type="InParanoid" id="A0A1Y1UR97"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1480"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1481"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1501"/>
            <end position="1514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX39665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1948" mass="211442" checksum="D1FF3CB6CD59E3A5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URP2</accession>
    <name>A0A1Y1URP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_607031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873600.1">
        <property type="nucleotide sequence ID" value="XM_022014044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URP2"/>
    <dbReference type="STRING" id="4999.A0A1Y1URP2"/>
    <dbReference type="GeneID" id="33555852"/>
    <dbReference type="InParanoid" id="A0A1Y1URP2"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="366"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="56361" checksum="6CD1235A06CC157C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URQ6</accession>
    <name>A0A1Y1URQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_12054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874301.1">
        <property type="nucleotide sequence ID" value="XM_022011956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URQ6"/>
    <dbReference type="GeneID" id="33553764"/>
    <dbReference type="InParanoid" id="A0A1Y1URQ6"/>
    <dbReference type="OrthoDB" id="2575809at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="184" mass="20882" checksum="E91CB0453E98D12A" modified="2017-08-30" version="1">MSTSSTSTRDEVIQLRTELEYSAFLNKGVLQTNAEHKVRIAELESENQSLRRSEKQLSRVEDELEDAQKALKEWESAAMTWERDRQKLKEALKVAKQAAEVLEAEKLDWINRFANLSEAFAAFIDNIDKARQEAASIQAGSSRRQTVRLSEQLPSKLDACSLLDLRQLLQRSPHRRHGGSSGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URZ7</accession>
    <name>A0A1Y1URZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_267192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874011.1">
        <property type="nucleotide sequence ID" value="XM_022012329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URZ7"/>
    <dbReference type="GeneID" id="33554137"/>
    <dbReference type="InParanoid" id="A0A1Y1URZ7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="353" mass="36343" checksum="3C90EFFB01F2834F" modified="2017-08-30" version="1">MLTKTASQPPQAPPAPQRTMSQRATSGPPPTSLNKHRTSMFGTIKKRFSILTSSDSKTPTTPAKDAAPATPSKSAQPVVVDQAAVKALPAVPPSPVPVTVIEASPAAPGRTDVSEFGATAEPLRELPARTTSHTPPRPAVATFSPADAPPLMATPPGITRSTPQSAIPTSSSPQLTQTLSRDSGARSMAGSVGSINRRSSVKGPRPMPSSPESKGGVSIPNSDPIPSRSRLSNPLPVPSLPAGASPPQLQSFPLGPMVHARSSSQSNGSSNNPFPEIVTPSTPGEQSEYSVGHTHTTTTGTSVRLVSPSATPEEDRALFLSSSDNVVPPHVEDGHKVPTRESSGESLQPSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US39</accession>
    <name>A0A1Y1US39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_659115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874529.1">
        <property type="nucleotide sequence ID" value="XM_022018885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US39"/>
    <dbReference type="FunCoup" id="A0A1Y1US39">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="GeneID" id="33560694"/>
    <dbReference type="InParanoid" id="A0A1Y1US39"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="562" mass="62284" checksum="2A261BF38BC55D72" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USW7</accession>
    <name>A0A1Y1USW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_42831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874789.1">
        <property type="nucleotide sequence ID" value="XM_022012760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USW7"/>
    <dbReference type="STRING" id="4999.A0A1Y1USW7"/>
    <dbReference type="GeneID" id="33554568"/>
    <dbReference type="InParanoid" id="A0A1Y1USW7"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="207"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Skg3/CAF120-like PH-like" evidence="3">
        <location>
            <begin position="336"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="667" mass="73744" checksum="8805CDD91199424A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT37</accession>
    <name>A0A1Y1UT37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_39370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874791.1">
        <property type="nucleotide sequence ID" value="XM_022012674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT37"/>
    <dbReference type="FunCoup" id="A0A1Y1UT37">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT37"/>
    <dbReference type="GeneID" id="33554482"/>
    <dbReference type="InParanoid" id="A0A1Y1UT37"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="208" mass="24415" checksum="24866D88ED3D1CD9" modified="2017-08-30" version="1">MQELDRELARLWRVSRTVHEMMRDRGYQVADYEINTSFDDFKQAHGSSGQVDRTNMSFTADHEEESGNRIYVYFCSDRNVSKANVKTFLGSMDRMNAQKGLLIYAEKLSPIAARAMQEMSSEYHLEHFKETDLLVNITHHFLVPKHTIMKTEDKQALIKKYRLKETQLPRIMITDPVARYYGLRRGQVMKIERASETAGRYVTYRICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTC2</accession>
    <name>A0A1Y1UTC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_647772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874546.1">
        <property type="nucleotide sequence ID" value="XM_022017714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTC2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTC2"/>
    <dbReference type="GeneID" id="33559523"/>
    <dbReference type="InParanoid" id="A0A1Y1UTC2"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="546" mass="60946" checksum="4267CC0412D6391A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTF8</accession>
    <name>A0A1Y1UTF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-amylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_56125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874980.1">
        <property type="nucleotide sequence ID" value="XM_022013017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTF8"/>
    <dbReference type="GeneID" id="33554825"/>
    <dbReference type="InParanoid" id="A0A1Y1UTF8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013141402" description="Alpha-amylase domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX41301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="195" mass="18714" checksum="622DF2072E389153" modified="2017-08-30" version="1">MIPANMFLSLLSCKTFSVAQDTSLSVTWTSGEPFVFVSTDTVSSSGLSAAAPSSVAESLTPSASFSDGQGRSTTPSGTGSDPQTLSASFSNGNGQSMTSSDAGSSPQSIAGTAPTIVQGSSPSSTSRLNTAIGAGNAAQPGASSGSPIGGGGGDQPDSDGTNPDIGGTGAGVTQVAFAGHAIAMAVVFVSGLVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUC2</accession>
    <name>A0A1Y1UUC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_648044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874833.1">
        <property type="nucleotide sequence ID" value="XM_022017767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUC2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUC2"/>
    <dbReference type="GeneID" id="33559576"/>
    <dbReference type="InParanoid" id="A0A1Y1UUC2"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010995090" evidence="5">
        <location>
            <begin position="24"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="6">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX41154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="712" mass="76515" checksum="E1F9F6F0B2DF4071" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUK1</accession>
    <name>A0A1Y1UUK1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_678620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874933.1">
        <property type="nucleotide sequence ID" value="XM_022019005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUK1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUK1"/>
    <dbReference type="GeneID" id="33560814"/>
    <dbReference type="InParanoid" id="A0A1Y1UUK1"/>
    <dbReference type="OrthoDB" id="5577714at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="50" mass="5822" checksum="9AA6CDEAF7C8FA31" modified="2017-08-30" version="1">MNRIPVVLTIDEIEYLLDQLPAPDKDEDALVTKLRETLKRSLEEVRKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUN1</accession>
    <name>A0A1Y1UUN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_613947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874963.1">
        <property type="nucleotide sequence ID" value="XM_022014551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUN1"/>
    <dbReference type="GeneID" id="33556359"/>
    <dbReference type="InParanoid" id="A0A1Y1UUN1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="61" mass="7072" checksum="25E553D6B62F95D5" modified="2017-08-30" version="1">MSVNRPPYMLRLPQHPFVLHHFEVLACLPPSLRSGIRMLSTDQSLIALYVYLAVQFRVTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5H4</accession>
    <name>A0A1Y1U5H4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_640347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867638.1">
        <property type="nucleotide sequence ID" value="XM_022017341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5H4"/>
    <dbReference type="FunCoup" id="A0A1Y1U5H4">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5H4"/>
    <dbReference type="GeneID" id="33559150"/>
    <dbReference type="InParanoid" id="A0A1Y1U5H4"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="430" mass="46492" checksum="190262590077600F" modified="2017-08-30" version="1">MSAPVTFGGEQYNATTGQPIDAPKKPHLYIGNLSPRVTEYMLGEIFAVAGPVVTAKIIQDRNFQHGGFNYGFVEYTDMRSAEQALQTLNGRKIFEAEVRVNWAYQGQQNKEDTQHHYHVFVGDLSPEVNDEVLAKAFGAFGTMSEARVMWDMNSGKSRGYGFLSFRDKADAEQAINAMNGEWLGSRAIRVNWANQKTQTGGGRPGGMGMPPMPSMTSPPQGSSSTPLGMGSGATGLAQPMSGSASGSGGSYSQPMSYDSVSRQVPDFNSTVYVGNLIPYTTQADLVPLFQGYGYIVEIRMQADRGFAFVKLDSHHNAAMAITHLQNQLVHGRPIRCSWGKDKAEGSSSGGQSPYPMQQPGANAYPQYGYYGGYNYGQTGVPGQPGQGETHNGGWDQAAAQAYYNSGGWGNYYTPQNDTTTSQNSNSTQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5I0</accession>
    <name>A0A1Y1U5I0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_288756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000028">
        <property type="protein sequence ID" value="ORX33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867646.1">
        <property type="nucleotide sequence ID" value="XM_022012389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5I0"/>
    <dbReference type="GeneID" id="33554197"/>
    <dbReference type="InParanoid" id="A0A1Y1U5I0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="162" mass="18040" checksum="F3FDEC80B5527C83" modified="2017-08-30" version="1">MSRRLVYGDLIVVPAPSLIDLQHLELPSHLRLLRPARYLHSDSNSNHHVVQPLRPDEEAPEAIPVGDCMPLAILYKHVRLDVPSPNMQRMIGYVRNEAVQDSPASLFCQAWIIASTLVSSTYGIMGLSPQLDPTSEALALQVTASDDRRPDLPLIRRFTTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5P6</accession>
    <name>A0A1Y1U5P6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_684322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
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                <person name="Andreopoulos W.B."/>
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                <person name="Lindquist E."/>
                <person name="Daum C."/>
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                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Dannebaum R.O."/>
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                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000021">
        <property type="protein sequence ID" value="ORX33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867776.1">
        <property type="nucleotide sequence ID" value="XM_022017284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5X7"/>
    <dbReference type="FunCoup" id="A0A1Y1U5X7">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5X7"/>
    <dbReference type="GeneID" id="33559093"/>
    <dbReference type="InParanoid" id="A0A1Y1U5X7"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000136">
        <property type="entry name" value="Probable phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="284" mass="31269" checksum="FC5B27996D691BC0" modified="2017-08-30" version="1">MTSQDQAGGSSRSDILTPQYNEQEIAAFNAELEGKSPQEILIWAVDHLDGLYQTTAFGLTGTAALDMISKISLDRHEIHLVPLIFLDTLHHFPETLALAQTASDHYLAPLHTYAPQVEPLNAEGFAAKYGSSLWETDEAAYDYLVKVEPAARAYRELGVRAVITGRRRSQGAEREGLKVLEVDERGLIKVNPLISWTFKEVKAYIDKEDVPYNTLLDQGYRSIGDVHSTAPPDPSLADSDAAERSGRWAGKAKSECGLHVNYFDMKARFENKSNGTENATATGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U641</accession>
    <name>A0A1Y1U641_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_647276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867815.1">
        <property type="nucleotide sequence ID" value="XM_022017639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U641"/>
    <dbReference type="FunCoup" id="A0A1Y1U641">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U641"/>
    <dbReference type="GeneID" id="33559448"/>
    <dbReference type="InParanoid" id="A0A1Y1U641"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="115"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="315" mass="35659" checksum="74673196530FCDE7" modified="2017-08-30" version="1">MPVAVPASSDPDQWIAHIRQCKHLPERQMKALCARVRDLLLEESNVHLVQSPVTVCGDIHGQFWDVLEIFRQGGEVPETNYIFMGDFVDRGYYSLETLSLLLALKARYPDKVTLLRGNHESRQITQVYGFYEECMQKYGNPSVWKACCTVFDHLNLAAIIDAEILCVHGGLSPDIRTLDQVRILPRAQEVPNEGAFCDLMWSDPDEVESWAVSPRGAGWLFGSKVTAEFNHINSLKLIARAHQLVQEGFKHMFDDSLVTVWSAPNYCYRCGNQASVMQVDTNGQTSFKVYSAAIENQTDQKNPALRRLQTPSYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6U2</accession>
    <name>A0A1Y1U6U2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_653815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868062.1">
        <property type="nucleotide sequence ID" value="XM_022018713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6U2"/>
    <dbReference type="GeneID" id="33560522"/>
    <dbReference type="InParanoid" id="A0A1Y1U6U2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="157" mass="17590" checksum="A4B72E89B8F1852F" modified="2017-08-30" version="1">MSQRENINLVEAEARKQLTDLSTGVFESLCQRLETCAEQSDGHKASAQNLCDSFKAWMTYPAARAVTFYYDQYTGPLDDSCDFQIRVTPSEDFHGSESRLVSLEVWKNTDDADNTEGRTLFNMPILATNDWQGGWQFKVDGRKVGWITSKVSSSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U796</accession>
    <name>A0A1Y1U796_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TLC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_637651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868187.1">
        <property type="nucleotide sequence ID" value="XM_022017028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U796"/>
    <dbReference type="FunCoup" id="A0A1Y1U796">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U796"/>
    <dbReference type="GeneID" id="33558837"/>
    <dbReference type="InParanoid" id="A0A1Y1U796"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="47"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="316" mass="35317" checksum="4DA814E639FAD1E4" modified="2017-08-30" version="1">MSFSPLPLLGPHIAVLLGSAGAFFGIQQLTHRFGPSCSKSWNGFDDRIKNGVASHVVSMAHALIIIPLALHAVKSDILARDPVFGYDRFVGNVLAISSGYFIWDTIDSLRYSTLGFVVHGACCLAVYLFSFRPFLAGFGPPFLLWELSTPLLNIHWFMDKLGLSTTYPTFFLINALAFMLVFFLARIVYGGYESMVFFHVMWTRRHEIPLHLHLIYCIGNLSLNALNWLWFSKMVKKMLARVSGDDKPVSESKRAARTNKMSPSEKQSLLEVSTPTSVSEDKMESTNGRQFKQTLSLPADPPSPNVSTSRKTSEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7F3</accession>
    <name>A0A1Y1U7F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_653640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868230.1">
        <property type="nucleotide sequence ID" value="XM_022018683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7F3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7F3"/>
    <dbReference type="GeneID" id="33560492"/>
    <dbReference type="InParanoid" id="A0A1Y1U7F3"/>
    <dbReference type="OrthoDB" id="2575974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012010935" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="36"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="56500" checksum="5FC0AEC286498AEE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7W5</accession>
    <name>A0A1Y1U7W5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_638970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867944.1">
        <property type="nucleotide sequence ID" value="XM_022017179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7W5"/>
    <dbReference type="FunCoup" id="A0A1Y1U7W5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="33558988"/>
    <dbReference type="InParanoid" id="A0A1Y1U7W5"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="TerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="923"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1033"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1167"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1220" mass="131727" checksum="154CF126363E858E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8E6</accession>
    <name>A0A1Y1U8E6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_653573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868589.1">
        <property type="nucleotide sequence ID" value="XM_022018672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8E6"/>
    <dbReference type="FunCoup" id="A0A1Y1U8E6">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8E6"/>
    <dbReference type="GeneID" id="33560481"/>
    <dbReference type="InParanoid" id="A0A1Y1U8E6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="37"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="526" mass="57171" checksum="A35F6DA523540264" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8G8</accession>
    <name>A0A1Y1U8G8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_683973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868086.1">
        <property type="nucleotide sequence ID" value="XM_022019204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8G8"/>
    <dbReference type="FunCoup" id="A0A1Y1U8G8">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8G8"/>
    <dbReference type="GeneID" id="33561013"/>
    <dbReference type="InParanoid" id="A0A1Y1U8G8"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="262" mass="29269" checksum="52AD2D87F21C33F9" modified="2017-08-30" version="1">MSWGGLKKATSRMGTTLMQKTGQIERTVDREFAEEESKYRILEKETGNLQKEAKSYLDAMRGMSASQTRIAETVSMFYSADRASDGAMSGHAYKAAVDELDAGVGRDLDAPFRATVLEPIGKLNSYFTNTNAAIEKRNHKMLDYDSARAKVKKLVEKPSDDPTKLPRAQAEHDEARDIFNILNDQLISELPLLVDLRIPYLDPSFEAMIRCQMRFAEEGYEKLSGVQRYFADSVRDDYANGALDGQVEGVLDEMKGLSICGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8L8</accession>
    <name>A0A1Y1U8L8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BD324DRAFT_643783</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868126.1">
        <property type="nucleotide sequence ID" value="XM_022017569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8L8"/>
    <dbReference type="FunCoup" id="A0A1Y1U8L8">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8L8"/>
    <dbReference type="GeneID" id="33559378"/>
    <dbReference type="InParanoid" id="A0A1Y1U8L8"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="8"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ORX33827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="827" mass="92031" checksum="2AC00204EAF2D7F7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8R8</accession>
    <name>A0A1Y1U8R8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_583275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868702.1">
        <property type="nucleotide sequence ID" value="XM_022013613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8R8"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8R8"/>
    <dbReference type="GeneID" id="33555421"/>
    <dbReference type="InParanoid" id="A0A1Y1U8R8"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="545" mass="61229" checksum="216DFD3C9A815D0C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8W7</accession>
    <name>A0A1Y1U8W7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_643671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868282.1">
        <property type="nucleotide sequence ID" value="XM_022017565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8W7"/>
    <dbReference type="FunCoup" id="A0A1Y1U8W7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8W7"/>
    <dbReference type="GeneID" id="33559374"/>
    <dbReference type="InParanoid" id="A0A1Y1U8W7"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="94"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="514"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="597" mass="64034" checksum="71FCC1FC083EBAC5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Z5</accession>
    <name>A0A1Y1U8Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_583401</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868751.1">
        <property type="nucleotide sequence ID" value="XM_022013622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Z5"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Z5">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Z5"/>
    <dbReference type="GeneID" id="33555430"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Z5"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="131"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="249" mass="27769" checksum="A691FF105101A593" modified="2017-08-30" version="1">MSIRYISQKVAQQIDEELMSASGAFSLDQLMELAGLSCAQALAKSFPVKTHRRVIVCCGPGNQGGDGLVAARHLHMFRYQPTVYLPKPGSKDIYQRLLTQVENLKIPVLKNEDEFQKSLTEQDVILDAIFGFSFKPPLRAPFHTILKLIGSSNVPIFSVDIPSGWDVEKGKQPLRTQPDEDGNSETVDTFNPEALISLTAPKEGVKEFKGRHWLGGRFVPDELARKFELNLPEYNDTDQVVELPSGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Z7</accession>
    <name>A0A1Y1U8Z7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">VHS domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_604723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868776.1">
        <property type="nucleotide sequence ID" value="XM_022013988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Z7"/>
    <dbReference type="FunCoup" id="A0A1Y1U8Z7">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8Z7"/>
    <dbReference type="GeneID" id="33555796"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Z7"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="8">
        <location>
            <begin position="185"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52251" checksum="922AC8D6BE0497E1" modified="2017-08-30" version="1">MLGPSRPWQSMSAVQALVEQACDPTLPAPNDAVNIELAELINRKKANSAREACHALLTHINSRNPNQALLALSVLEHLVRNCGYPVHLQISTKEFLNELVRRFPERPPMVTGRVMGRILELIHEWKNTLCVHSKYKDDLVHIRDMHRLLSYKGYRFKAFDAARAMASSNPNEDLKSPEELEEEDRAAKSAKLQELIRRGTPRDLAAAQDLMKALAGAEPDKAPDYASQTLGELEKVQSKAILLNDMLNNAKEGERIGVDGDVYDQVAAACRGARPKIQRWIEQDAGEREGMMERLLLCNDLINNALDRYEACKVGDWAKAQALVEASNPNKKAADLISFDAFADDEPMGGGVSLPADAGSSSAGMTSSGLPLDLFTAPSPTPSPGLAPERKVSGQRTNPMDFFNIPGPQGSMGWNSGRSAQVQQQPMQGYSLSPAPQSTAAYAPQQPQQQAPQQAPQPAPQPPQPKKDAFADLVNLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U938</accession>
    <name>A0A1Y1U938_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_638041</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868305.1">
        <property type="nucleotide sequence ID" value="XM_022017073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U938"/>
    <dbReference type="FunCoup" id="A0A1Y1U938">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U938"/>
    <dbReference type="GeneID" id="33558882"/>
    <dbReference type="InParanoid" id="A0A1Y1U938"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="434"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="500"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="567"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="847" mass="97099" checksum="706B58E6BE087738" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9C0</accession>
    <name>A0A1Y1U9C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA-intron endonuclease Sen2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_636639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868385.1">
        <property type="nucleotide sequence ID" value="XM_022016917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9C0"/>
    <dbReference type="FunCoup" id="A0A1Y1U9C0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9C0"/>
    <dbReference type="GeneID" id="33558726"/>
    <dbReference type="InParanoid" id="A0A1Y1U9C0"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="9">
        <location>
            <begin position="383"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="526" mass="57871" checksum="8F4F64CED10C2FF0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9G7</accession>
    <name>A0A1Y1U9G7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_583117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868915.1">
        <property type="nucleotide sequence ID" value="XM_022013596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9G7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9G7"/>
    <dbReference type="GeneID" id="33555404"/>
    <dbReference type="InParanoid" id="A0A1Y1U9G7"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126174" checksum="4876174DF3DA8AAC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9M6</accession>
    <name>A0A1Y1U9M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transcription initiation factor tfIID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_637230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868522.1">
        <property type="nucleotide sequence ID" value="XM_022016980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9M6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9M6"/>
    <dbReference type="GeneID" id="33558789"/>
    <dbReference type="InParanoid" id="A0A1Y1U9M6"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="116" mass="13069" checksum="950B91CF6C4F2E14" modified="2017-08-30" version="1">MLRSMMDPEQARRFDAFSSVVIPKGPITKLNKDLFDQKLQGNLSAVLAGMAKILITEVVELAKELQPHSAMPSGRLRPYHLRLAREELERRGVLSGTRRNGGTGTALRPYKPLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9N7</accession>
    <name>A0A1Y1U9N7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_638655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868104.1">
        <property type="nucleotide sequence ID" value="XM_022017141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9N7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9N7"/>
    <dbReference type="GeneID" id="33558950"/>
    <dbReference type="InParanoid" id="A0A1Y1U9N7"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="193"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="619" mass="67030" checksum="F5A465997FC3E4F4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9R5</accession>
    <name>A0A1Y1U9R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_634930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869015.1">
        <property type="nucleotide sequence ID" value="XM_022016772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9R5"/>
    <dbReference type="FunCoup" id="A0A1Y1U9R5">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9R5"/>
    <dbReference type="GeneID" id="33558581"/>
    <dbReference type="InParanoid" id="A0A1Y1U9R5"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="375" mass="41692" checksum="7FBFB0D7C47EC5F5" modified="2017-08-30" version="1">MQTSDPGLLFRTSADILAAEARARKAVALEKRGSPFSLGAKILDLKLGRDEVIVGDSSGAVKCLDELGSTRRKVYRGHAGPVTCVTLAPCYQSESTWTALFSGSWDKSIRIWNHDTGELKASLEGHSDFIKSLLSLTSPYELLLSTSSDKTIRVWDLELLRSGQAPSCVQVLRDHTRPITSCTLQYGAEMFVWTGDSMGVVIKWTVRNRRMVLLQTTACHETSITGIEATEDGLWTCSMDKTAQFRQWSSFDKPIILHHASYVTSVLPLKDTSVSDIVLTGDDDGNIRVWSIESEEARLKATVEGHGAQVSVMRQCRRMENGWEVFSGSLDMTLRHWTLEDLLHPPLLLTGDDTPDGEESLLTEEEERELEELMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9S4</accession>
    <name>A0A1Y1U9S4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_653037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869021.1">
        <property type="nucleotide sequence ID" value="XM_022018593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9S4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9S4"/>
    <dbReference type="GeneID" id="33560402"/>
    <dbReference type="InParanoid" id="A0A1Y1U9S4"/>
    <dbReference type="OrthoDB" id="2575061at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="801" mass="88326" checksum="28A4180F4BA6B4D0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA26</accession>
    <name>A0A1Y1UA26_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868223.1">
        <property type="nucleotide sequence ID" value="XM_022017635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA26"/>
    <dbReference type="FunCoup" id="A0A1Y1UA26">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA26"/>
    <dbReference type="GeneID" id="33559444"/>
    <dbReference type="InParanoid" id="A0A1Y1UA26"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="155" mass="17907" checksum="0DA3D41F551CF443" modified="2017-08-30" version="1">MSIPGFDAETAGNNEEIEMQFAVKTVEHLEAYERLISGIPPRNLKLTPMDNELHENFLSTFPEYASPEALRNLNEDEMKSAKGKERWRNFILPYEKRLKDYNFGTLVRKDSDRGYAEDNSILVTRTQFFAIEIARNRAGLNDKIYQEAQAKKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAH5</accession>
    <name>A0A1Y1UAH5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Thiolase, N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_633745</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869267.1">
        <property type="nucleotide sequence ID" value="XM_022016653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAH5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAH5"/>
    <dbReference type="GeneID" id="33558462"/>
    <dbReference type="InParanoid" id="A0A1Y1UAH5"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="415" mass="43535" checksum="17406BCA48B20BCB" modified="2017-08-30" version="1">MTSALQSLTSVLPSMGRARLLINSADDVVIVSACRTAITKAKKGGFKDCLPEDLLAAVFKETLKRSKVDPSKIEDIVVGNVLPPGGGANVARMAQLYAGIPYTTPINTVNRQCSSGLTAVAQIANEIKSGEIDIGIGAGVEHMTAHYGAGVLPERMSDAVLSNPESADCLLPMGITSENVAKQYNITRDAQDSFAADSYAKAAAAQKAGKFREEIVPVRVKWSDPKSEDEKEIIVDSDDGIREGVTKESLSKLKPAFAKDGATHAGNASQVSDGAAAVLLARRSVAQKLGLPILGKFVVSAVVGVPPKVMGIGPAFAIPKVLQKAGITKDDVDFYEINEAFASQAVMSVQHLHIPFDKVNPVGGAIAMGHPLGCTGARQIATGFSEAKREKKKVFVTSMCIGSGMGMAAVFVNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB49</accession>
    <name>A0A1Y1UB49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_582371</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869453.1">
        <property type="nucleotide sequence ID" value="XM_022013554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB49"/>
    <dbReference type="FunCoup" id="A0A1Y1UB49">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB49"/>
    <dbReference type="GeneID" id="33555362"/>
    <dbReference type="InParanoid" id="A0A1Y1UB49"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="594" mass="66800" checksum="6327190A836C128F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB69</accession>
    <name>A0A1Y1UB69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosaminyl transferase component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_86660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869471.1">
        <property type="nucleotide sequence ID" value="XM_022019269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB69"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB69"/>
    <dbReference type="GeneID" id="33561078"/>
    <dbReference type="InParanoid" id="A0A1Y1UB69"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="468" mass="52091" checksum="AADFE5CF413752BF" modified="2017-08-30" version="1">MTVYWPRDGIQKRDGTLIGFRQGSIDIVVASVDIRVDLDNCLALLNDESQGHGRSKGAVKVLGRAHESSAPTSVTQGSSRELDISVDQRGMPTPRGDRSSYILYGSSTGHNGLQQLKLKESHSIGGSLSRQEEWSRRSKGTSSQSTADDENLSDLQLDSCRALRTLLSDSRANEIPGIQDRQDCPSIPSSPFGAMQTASAKAMSFLVSHSATLLWQSATFRQTLIRLDHLRVISDLSSSQIQLLYSMCLAVDILLGLAARHLINAHTTTLHELMKRAFSTYMIDWVDHALGWLNDWPAGLKLNTPLSDFFRTNLGMIIRTWGELFSPHMDRISSVILNQLLPRISTLGLTLALAVVHDALLLSSLHLRLCWNLTRWICLWQLESLSGLWNLFRGKRWNMLRKRTDSYEYDVDQLFVGTLFFTVSIFLLPTVVVYTALFGLVMCVVKATQRAMDVVVLCSVRGPARASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB71</accession>
    <name>A0A1Y1UB71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PhyH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_642970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869478.1">
        <property type="nucleotide sequence ID" value="XM_022017519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB71"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB71"/>
    <dbReference type="GeneID" id="33559328"/>
    <dbReference type="InParanoid" id="A0A1Y1UB71"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30507" checksum="B136D4B946E25229" modified="2017-08-30" version="1">MYKLDSTQIEQYHRDGFLILRASEHGLLPDVTALPSWTDEVRHWPLSESHGKWMPYMEDTTNGKQIMRTEKFKDYHQGFESLLDGEALRAILSQLGGQSMILFKDKINYKLPGGNGFAAHLDAPAYDHICKVEHVTANIAIHPADAANGCLEVVPGSHKMAVDFIAGGHITDEWCDAHEWVSVPLEVGDMLIFGSHLAHRSGPNTSQRERAMLYATYSAESDGKDLREKYYAHRREAFPPDHERKADVDYSEGYKTYGFAAPFSRPTAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB82</accession>
    <name>A0A1Y1UB82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_632243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869490.1">
        <property type="nucleotide sequence ID" value="XM_022016501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB82"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB82"/>
    <dbReference type="GeneID" id="33558310"/>
    <dbReference type="InParanoid" id="A0A1Y1UB82"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="651" mass="72398" checksum="20DBC5441463D8C3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBP3</accession>
    <name>A0A1Y1UBP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial F1-F0 ATP synthase subunit F of fungi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_632949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869653.1">
        <property type="nucleotide sequence ID" value="XM_022016577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBP3"/>
    <dbReference type="FunCoup" id="A0A1Y1UBP3">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBP3"/>
    <dbReference type="GeneID" id="33558386"/>
    <dbReference type="InParanoid" id="A0A1Y1UBP3"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="97" mass="10472" checksum="98998CD04B5A50F3" modified="2017-08-30" version="1">MHASVARRSLGALIPPKIATPGAVSSGSTSARTANVVEFYSRLPKGSASASYNNSIKNKYFNQARGTALGYTVVGMFVMGYSISYYLHLRHHKTGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBQ9</accession>
    <name>A0A1Y1UBQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline-phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_633008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869670.1">
        <property type="nucleotide sequence ID" value="XM_022016588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBQ9"/>
    <dbReference type="FunCoup" id="A0A1Y1UBQ9">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBQ9"/>
    <dbReference type="GeneID" id="33558397"/>
    <dbReference type="InParanoid" id="A0A1Y1UBQ9"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="537" mass="59542" checksum="6EF62FF970C06968" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCB1</accession>
    <name>A0A1Y1UCB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_631180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869852.1">
        <property type="nucleotide sequence ID" value="XM_022016412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCB1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCB1"/>
    <dbReference type="GeneID" id="33558221"/>
    <dbReference type="InParanoid" id="A0A1Y1UCB1"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="539" mass="61342" checksum="A2EDA1057ED8B4DA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCD4</accession>
    <name>A0A1Y1UCD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cell wall organization and biogenesis-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_634072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869372.1">
        <property type="nucleotide sequence ID" value="XM_022016700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCD4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCD4"/>
    <dbReference type="GeneID" id="33558509"/>
    <dbReference type="InParanoid" id="A0A1Y1UCD4"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012305026" evidence="4">
        <location>
            <begin position="23"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="62"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="363" mass="39652" checksum="8FEF148EEE276FCF" modified="2017-08-30" version="1">MPRTRLPLVLLGLSAIVPLTLAQTYCNATSLCPESAPCCSEYGYCGSGTFCLGGCEPMHSFSPTSCRPNPICQSMTTTFANDVSRIQQVASEWNGNASAYDWYVNSGQIIPSSDGIKLVLNETNGGTKISSTRYVHYGKIDFVLETSKWPGVVTAAITMSDVKDEIDWEFTGSNTTLAQTNYWFMGIANYSDSQGLSVDVSSDTSANYHTYTFDWQEDYLNWMIDGNVVRSLQKQSTLSSDGTTYKYPTTPSQIQISIWPAGINTSAEGTIAWAGGMINWQDPDYVANGYFWNTIQSVTITCADDPNQASNTTGWAYSDSKGQTVPTVYDTTASLLINGGGRTTMSWTMYAVGVFTILMTMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCE5</accession>
    <name>A0A1Y1UCE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_68779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869836.1">
        <property type="nucleotide sequence ID" value="XM_022019218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCE5"/>
    <dbReference type="GeneID" id="33561027"/>
    <dbReference type="InParanoid" id="A0A1Y1UCE5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="194" mass="21135" checksum="DF1CA69D328D63C8" modified="2017-08-30" version="1">MKTTTSLYSRCPPSDIGSSVRHQACLSMQPRPGRNPAQRQLSYTIEPLLTPPWRGTGQVLMDPPSTSASCVSGPRLIDAQKATELCSRASHDADVNCTSISEASSCECRMLLVKLICPLRWPFASIFLEQHNHKAAHISTHTDPSPGRRYSHADGDNRSLDRVGHTSITEGESGQILEAQALVAQTSSSRQRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCH7</accession>
    <name>A0A1Y1UCH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Abscisic acid G-protein coupled receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_631505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869915.1">
        <property type="nucleotide sequence ID" value="XM_022016440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCH7"/>
    <dbReference type="GeneID" id="33558249"/>
    <dbReference type="InParanoid" id="A0A1Y1UCH7"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="401"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="580" mass="63537" checksum="DAD287492E9F3735" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCP7</accession>
    <name>A0A1Y1UCP7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869484.1">
        <property type="nucleotide sequence ID" value="XM_022018494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCP7"/>
    <dbReference type="GeneID" id="33560303"/>
    <dbReference type="InParanoid" id="A0A1Y1UCP7"/>
    <dbReference type="OrthoDB" id="2561286at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012801854" evidence="2">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="94" mass="10793" checksum="4DD8A1B72D067087" modified="2017-08-30" version="1">MRCSILISLIALAVQVMAYEHGEIRSNVAVRSDGKGGIEHFYERDRIAHEEQKRQASDYPEPRRRSQKKRQDPMLDYYPVKSDGKGGVMPFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCT8</accession>
    <name>A0A1Y1UCT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_629290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869987.1">
        <property type="nucleotide sequence ID" value="XM_022016190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCT8"/>
    <dbReference type="FunCoup" id="A0A1Y1UCT8">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCT8"/>
    <dbReference type="GeneID" id="33557999"/>
    <dbReference type="InParanoid" id="A0A1Y1UCT8"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="59702" checksum="D0B675BA81ACEBC2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCX4</accession>
    <name>A0A1Y1UCX4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CDF zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_629429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870027.1">
        <property type="nucleotide sequence ID" value="XM_022016210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCX4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCX4"/>
    <dbReference type="GeneID" id="33558019"/>
    <dbReference type="InParanoid" id="A0A1Y1UCX4"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="38115" checksum="5D2754536DE88AD2" modified="2017-08-30" version="1">MVSRTTRLSIVLGVSIAFFGVEIGVGFKTKSLALIADAFHYLNDVISYALALVATRLAKRAKGPPGYTYAFRRAEIVGAFFNATFLLALGVSIFLQAIERFVNLPEVDHPLWVLIVGCVGLALNIVCMLTVHEHGGHGHGAKAGPSGSNGDQLLVELNRIQVPGYGFARVDHSSHNHATPKDTPPAKSLGLAGVLMHLMGDAVNNVGVILAAAIMWRLSSAKRFYADPAASLAISLIIIGGAIPLSLKSSRVLLEAAPKDLDIKAVQEDLQTIPSVQEIHDLHIWHLTESDLLATFHCRTSVPDIKSWLDVERELKSCLGAYGITHVTISPELATMEDHGPAHDEMDCGVGSGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD87</accession>
    <name>A0A1Y1UD87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_662383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869251.1">
        <property type="nucleotide sequence ID" value="XM_022018901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD87"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD87"/>
    <dbReference type="GeneID" id="33560710"/>
    <dbReference type="InParanoid" id="A0A1Y1UD87"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="34448" checksum="4353FCB043468049" modified="2017-08-30" version="1" fragment="single">SYVDHDTAFAEGLAFWTQSGVPGIQAEHWAETDEGELRRSVRISTKALFQGGLILVDMALVPWGCGVWPAVWLLGYDAPWPYAGEIDIVEGIQAMTSKHTPAGCALDQTPGLFTGTVANTNCDSTEGNSGCSIVSPSNTSFGMPFNDLGGGLFACLWDKSGIRMYNWMRADIPQDIKSEQPNTTSWETPVATWSSSTCDPYAFFHPQQIVLNVNLCGDWAGGNYGSYPYCPGTCSSYITNPHNLNNTVMLINSIKVFQMEGAPIVTEQALTANNQTGAGGYVRRLPSSGYRTSTRADMEVMLFLISALSMALGPLRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDX6</accession>
    <name>A0A1Y1UDX6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870323.1">
        <property type="nucleotide sequence ID" value="XM_022018343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDX6"/>
    <dbReference type="GeneID" id="33560152"/>
    <dbReference type="InParanoid" id="A0A1Y1UDX6"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="150"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="423" mass="44795" checksum="17A678C63851811B" modified="2017-08-30" version="1">MIIVQYTSHGGVSELVHPDDTLATHWRLGTVHWARGDAWAKSSRAWNRVQICDGSRTVCVASNPLIPPGCVWPDAAQPSGVQASPNVSLSPSTVSNTILSSTAPVISARTSSTALSTASDQPSAAVSGAVPSVSASTGDGQRPSTQFSNPHYAIYHNRASRTLPSSAADIKPWNRWYFAFWQTNGPQDAVATFAAMPESDRQAMIADFHANGIAIMVSAFGANDVPTTSGANPTETANALAAFVKQYGLDGCDVDYEDSGAFITGTAYDWLLTFQTALRAQLPAPYIISHAPQPAYMITGQYTTKGGYKELHAAVGSGIDFYSVQYYNQGSYTPYTDCDSLITSAPDGSALLQVAESSGIPLNKLVIGKPLNGEDVSNSGLMDAATLGQCYQMAKSNGWNAGIMVWQWETDGAPAFLNTVLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDZ1</accession>
    <name>A0A1Y1UDZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleotide-diphospho-sugar transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_609547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869485.1">
        <property type="nucleotide sequence ID" value="XM_022014158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDZ1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDZ1"/>
    <dbReference type="GeneID" id="33555966"/>
    <dbReference type="InParanoid" id="A0A1Y1UDZ1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="96835" checksum="EF434F6CF00A53A7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDZ6</accession>
    <name>A0A1Y1UDZ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_628099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870364.1">
        <property type="nucleotide sequence ID" value="XM_022016084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDZ6"/>
    <dbReference type="FunCoup" id="A0A1Y1UDZ6">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDZ6"/>
    <dbReference type="GeneID" id="33557893"/>
    <dbReference type="InParanoid" id="A0A1Y1UDZ6"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="459" mass="52436" checksum="0B63567971DC494C" modified="2017-08-30" version="1">MCPGSVRVAVIGAGASGLAQLKQLLDAFARPNTPQLDVVVYESQREVGGTWFRSSHDKKKYIRHTDSDGQLFFSPDAENPSPMYDGLRTNLPYDLMSYRDFPMEHDDIFPDQPAVERYLRDYAKKFDLYKYIRFNTPVKRLYRHGKWRIETDTVEDFDFVCVANGHYADSWIPLIPGLDSFPGEVLHSRYYRCPEDYAGKSVMVVGSFASGSDLSRQLAGLNLTGRSMTVYLSSSGSTYSPPPGPDDPPQPWREYIRNVPLISRIDETKISFEDGSQVDDVDTLIFATGYRYSLPFCKAFDEPWKSTPPLDRIDGSLSGLSMRQLDELLLFLKDDRTISFPVLQYQIVPFPLAEVQARLTAFLWAGLFMLPEHLNLPSNPSNHHSTPPATPPDTPVRKVVSMRQNLVFGAPYEFIYAEYLMDLMRGVDGDDTPSHWQRIEPWRRERRADKALRRKLLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE25</accession>
    <name>A0A1Y1UE25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_628201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870394.1">
        <property type="nucleotide sequence ID" value="XM_022016098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE25"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE25"/>
    <dbReference type="GeneID" id="33557907"/>
    <dbReference type="InParanoid" id="A0A1Y1UE25"/>
    <dbReference type="OrthoDB" id="2587430at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="259" mass="27427" checksum="19F9FB388F74DA12" modified="2017-08-30" version="1">MSSQQQPQAARVALVTGGNRGIGKSIVLALAEKGISVVFTYNSHPEEPPAVIESVESLGNGAKAASLQLNVTEFDKYDTFLSSLQSILKDWGYTQLDIFIPCAGIGSITPFGQINAQTIDDLYNIQFKAPILLTQLVAPILKEKTSVIITISSGLARFSLPPLGVYAGLKGGIEVWTRYLAKELGSKGIRAICARVGAVESDFGGGRVRDDKDTNKHIASTIALGRVGLPSDIGPAIANIIDLTWVTGTVIEMSGGQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEL6</accession>
    <name>A0A1Y1UEL6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_602464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870075.1">
        <property type="nucleotide sequence ID" value="XM_022013946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEL6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEL6"/>
    <dbReference type="GeneID" id="33555754"/>
    <dbReference type="InParanoid" id="A0A1Y1UEL6"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="773" mass="85693" checksum="12A5E4B4D9D0736D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEQ0</accession>
    <name>A0A1Y1UEQ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870136.1">
        <property type="nucleotide sequence ID" value="XM_022016263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEQ0"/>
    <dbReference type="GeneID" id="33558072"/>
    <dbReference type="InParanoid" id="A0A1Y1UEQ0"/>
    <dbReference type="OrthoDB" id="2384258at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012553385" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="116" mass="12584" checksum="709FFB1B145BF0BB" modified="2017-08-30" version="1">MLGIIAILCLAHTATALHLPSWLARHEGRLHGAKAENALRRRADQSYIASVPGPICTGPSCYIGCFHDSWTRTVGNQSISSNSMTVDSCQEICLRGAYSYAGLEGGRQVRSERYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UER5</accession>
    <name>A0A1Y1UER5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">UEV domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_651911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870133.1">
        <property type="nucleotide sequence ID" value="XM_022018411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UER5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UER5"/>
    <dbReference type="GeneID" id="33560220"/>
    <dbReference type="InParanoid" id="A0A1Y1UER5"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="11">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="10">
        <location>
            <begin position="357"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX36004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="423" mass="47188" checksum="9D90A7D18AE433AF" modified="2017-08-30" version="1">MPSLDLTRDWLKNVLQPYPSRDRIQTEVLDVLQQRRTLAVKTDAFTFDNGQTALLLLLHGTLPIHYRGATYHIPIHLWIPLEYPRSPPLAFVVPTKDMGVRKGREVDPSGRIREEVVNEWWSRSDKGIETLLQQLIGVFSITPPVFARPPGTQPVRHATSSSSPPPPPARPDSLPQYASHLHSHRQESPPVPDRPRQASAFHTTPASPSAQWHPAVSSSQAPPVNRPQHPVHPARPTQDLLSSADDISIAAPAPPSKPPPPSLLHLHAILLPHLNASLPVLVHSLQTNRQHLLDRREDLTSGEPAIRDEMARLEAVKKVCDSVGRKMDNVVAQGETRVAELESRGEISVDEVVCGISIVHNQLIDLVAEDNAIEDTIFHMTRALDAERIDIDRFVKSVRSLAREQYMKRALIERILGNMGQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF19</accession>
    <name>A0A1Y1UF19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD324DRAFT_603017</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869829.1">
        <property type="nucleotide sequence ID" value="XM_022013956.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UF19">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF19"/>
    <dbReference type="GeneID" id="33555764"/>
    <dbReference type="InParanoid" id="A0A1Y1UF19"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000051">
        <property type="entry name" value="Helicase SWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="22">
        <location>
            <begin position="439"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="1050"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1582"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="175"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="303"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="570"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="721"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="855"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="970"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1831"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1921"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="571"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1007"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1844"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1855"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1887"/>
            <end position="1905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORX35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1954" mass="218695" checksum="978FEEDD55339D7F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF82</accession>
    <name>A0A1Y1UF82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_681473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870772.1">
        <property type="nucleotide sequence ID" value="XM_022019121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF82"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF82"/>
    <dbReference type="GeneID" id="33560930"/>
    <dbReference type="InParanoid" id="A0A1Y1UF82"/>
    <dbReference type="OrthoDB" id="2560920at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010995532" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="219"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="30445" checksum="255F6AE71DDA85E0" modified="2017-08-30" version="1">MLRLFLVALLAAQSAVAITNFIGCATELLAGCIAQVGITDQPTCVDKCAASGYRYIYYQDSLDSPCYCSANYPTVNDFTPSSSPSCDTSHYTVERIVGTFTYQFCAHNVGGTSSFSGTVSTIEDCFSSCGPYTWASWINNGGTFCGCWADSAPSFTNDQTCTYPVYKHTAGSTDASGIYRKRDAAPKRMLAGSNGVSCPGNLLPCLVAPTSDPSWEDSYECLDTVSDLEACGGCPYGLHPAASPFIGSAVDFGQDCSAIPGVALGGVTCAASSCVVTACRAPYELDNGICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFF4</accession>
    <name>A0A1Y1UFF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-box-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_642473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870337.1">
        <property type="nucleotide sequence ID" value="XM_022017487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFF4"/>
    <dbReference type="FunCoup" id="A0A1Y1UFF4">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFF4"/>
    <dbReference type="GeneID" id="33559296"/>
    <dbReference type="InParanoid" id="A0A1Y1UFF4"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24624" checksum="71D45365EF20628A" modified="2017-08-30" version="1">MSLALPSSAGPSSGKVKAPTPSAVSQSGSATDGKPVTSVPEITAVQGLVPTLQNIVATVNLECRLDLKTIALHARNAEYNPKRFAAVVMRIREPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFEAKFAEFKIQNIVGSCDVHFPIRLEGLAFSHGAFSSYEPELFPGLIYRMMKPKVVLLIFVSGKIVLTGAKVREEIYMAFNQIYSVLVEFRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFY0</accession>
    <name>A0A1Y1UFY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_514435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870104.1">
        <property type="nucleotide sequence ID" value="XM_022012972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFY0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFY0"/>
    <dbReference type="GeneID" id="33554780"/>
    <dbReference type="InParanoid" id="A0A1Y1UFY0"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="723"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="831"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="874" mass="94126" checksum="F4BAF0EDE538441A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFZ8</accession>
    <name>A0A1Y1UFZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_628821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870537.1">
        <property type="nucleotide sequence ID" value="XM_022016149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFZ8"/>
    <dbReference type="FunCoup" id="A0A1Y1UFZ8">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFZ8"/>
    <dbReference type="GeneID" id="33557958"/>
    <dbReference type="InParanoid" id="A0A1Y1UFZ8"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="134"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="394"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1084" mass="121738" checksum="3A853E0B28E46059" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG59</accession>
    <name>A0A1Y1UG59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_624587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871088.1">
        <property type="nucleotide sequence ID" value="XM_022015716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG59"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG59"/>
    <dbReference type="GeneID" id="33557525"/>
    <dbReference type="InParanoid" id="A0A1Y1UG59"/>
    <dbReference type="OrthoDB" id="2564640at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1240" mass="137495" checksum="702E9F9C91166783" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGJ1</accession>
    <name>A0A1Y1UGJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L22/L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 33 different proteins. The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and at least 46 different proteins. uL22 is associated with the polypeptide exit tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871211.1">
        <property type="nucleotide sequence ID" value="XM_022015762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGJ1"/>
    <dbReference type="FunCoup" id="A0A1Y1UGJ1">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGJ1"/>
    <dbReference type="GeneID" id="33557571"/>
    <dbReference type="InParanoid" id="A0A1Y1UGJ1"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000012">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="184" mass="20581" checksum="F51C53EB211AC85F" modified="2017-08-30" version="1">MVRYAAASIASANPEKFAKARGEYVRTHFKNMREVAAALNGMNLKKAYTYLGDVQEHKQIIPFRRHAGGIGRASQAKQFKTTKGRWPEKSVKYILRLLKNAESNADAKDLDVDELVIKNIVVNQAPKTRRRTYRAHGRINPYQGHPCHIEIFLSTPSVEIPRAKDLDVAAGSSRKGKKVAAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGR9</accession>
    <name>A0A1Y1UGR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_580319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870773.1">
        <property type="nucleotide sequence ID" value="XM_022013433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGR9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGR9"/>
    <dbReference type="GeneID" id="33555241"/>
    <dbReference type="InParanoid" id="A0A1Y1UGR9"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF1">
        <property type="entry name" value="AMMONIUM TRANSPORTER AMTB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="459"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="61412" checksum="3D39B9725B759159" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGT5</accession>
    <name>A0A1Y1UGT5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_625079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871217.1">
        <property type="nucleotide sequence ID" value="XM_022015765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGT5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGT5"/>
    <dbReference type="GeneID" id="33557574"/>
    <dbReference type="InParanoid" id="A0A1Y1UGT5"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="815"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="966"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="967"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1148" mass="126561" checksum="4481609C91A67B15" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGX7</accession>
    <name>A0A1Y1UGX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative chaperone activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_580018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870823.1">
        <property type="nucleotide sequence ID" value="XM_022013421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGX7"/>
    <dbReference type="FunCoup" id="A0A1Y1UGX7">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGX7"/>
    <dbReference type="GeneID" id="33555229"/>
    <dbReference type="InParanoid" id="A0A1Y1UGX7"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="336" mass="35878" checksum="E28F0C5CCA5166F3" modified="2017-08-30" version="1">MGEPKPLTAYQQTYHWRNKNCGPWAREWIKKSVPGIKVEDGKQRVEVDEVTSVSGDCDLGQRKGKLLTIYDLEVELSWTGSDAEGSEVKGKIKCPEVSHEAIDGLSEYVYEITITTPSPANSSANALSSFVRSDLLPRLSEKFNSLRPALLEAHGGPSDEATSGVSTPQNQHYSPAPPGSANASSTTSATGATAKSAPVTSPSTTTPKPALTGTKVVEVKAELQASAADLWGLLTDQSKIPMWSRAEAKFSPSPDSSYTLFGGNVTGKIVSAEAPTKLVTTWQLKKSNWPSDHFATMTIVLDQGSNSTNVTFTLDGVPAGQEGELENALDGFYIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHH7</accession>
    <name>A0A1Y1UHH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871015.1">
        <property type="nucleotide sequence ID" value="XM_022018332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHH7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHH7"/>
    <dbReference type="GeneID" id="33560141"/>
    <dbReference type="InParanoid" id="A0A1Y1UHH7"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36528" checksum="6187E4F8F9580BA7" modified="2017-08-30" version="1">MPATLPPFSDLPIQRPGPPLNAWGLYGQDDELGRLNLITPEARLKGAKAVKHGIAINLNMPLDFPKLHAERGALEHTINHRKHANDDILTFNTQGSSQWDGFRHYPYQHYPEKGQYRYYGDQTTEEARDKSVLRNGTQNFVHHPISSRAHLLDIERYINRHNLKPLTYFAESSGIPVEYLEDCAKESNVDIQPGDILIVRIGYIDALMNLPETERNTLVEREVRAWPGVEPSEEMMKWHWEKGIAAVVTDGVAYEKIPFPPDKLSLHQVFLAGWGLPIGELFDLRKLGEECARLNQYTFLFTSMPLYVNGGIASPPNAQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHM6</accession>
    <name>A0A1Y1UHM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_385136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871550.1">
        <property type="nucleotide sequence ID" value="XM_022012643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHM6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHM6"/>
    <dbReference type="GeneID" id="33554451"/>
    <dbReference type="InParanoid" id="A0A1Y1UHM6"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000053">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="837" mass="89914" checksum="9B838CD8494FC45A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHR3</accession>
    <name>A0A1Y1UHR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_387012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871587.1">
        <property type="nucleotide sequence ID" value="XM_022012649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHR3"/>
    <dbReference type="GeneID" id="33554457"/>
    <dbReference type="InParanoid" id="A0A1Y1UHR3"/>
    <dbReference type="OrthoDB" id="2587968at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="560" mass="62890" checksum="702E9D00CA276EE1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHR8</accession>
    <name>A0A1Y1UHR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger protein 830</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_650171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871588.1">
        <property type="nucleotide sequence ID" value="XM_022018110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHR8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHR8"/>
    <dbReference type="GeneID" id="33559919"/>
    <dbReference type="InParanoid" id="A0A1Y1UHR8"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29988" checksum="067BEDE96CB9E5C4" modified="2017-08-30" version="1">MDAKSLLRAKKAGAKIEHPYASYTSGQLKCSICAVPVTQWDAHLLTKQHRTSVAREKASQAKASAKRPAEDSSRSDMKRVKTDKAAESSSSSSSLPIGFFDAPRSGDGGEDEEEDKEDERPQPTSAPPAAVAVPSKPEPTGDLELDAFLSSLNEPDPELSQPAPSSSRRARQRDLSPSDLGVASYSAAPVRIVPETVKEPEEDEEPEPEETEAERRARLEREEKEEIMERLEAEQRAQEDADSRVEALKARMEMLKARRKARPVNVDKKAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHW1</accession>
    <name>A0A1Y1UHW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871102.1">
        <property type="nucleotide sequence ID" value="XM_022015722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHW1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHW1"/>
    <dbReference type="GeneID" id="33557531"/>
    <dbReference type="InParanoid" id="A0A1Y1UHW1"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF32">
        <property type="entry name" value="G-PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27651" checksum="6711573BB2750702" modified="2017-08-30" version="1">MVNMADAKRRFDPAAHLSKQGWKGKGSALKQGHSTRPLAVVKKKTLSGIGKDRDEAIPFWDHIFAATAASLQSSIASSPAASTSTSPAPPSVNPSSSSTAGSSLSISARKGKEAARRGLYSKFLKGKTLAPEKVTFDELVPGVTSDIVPEEIPNDTAVEGKKRKKKKKRRDETVREETELPEVESKEDRKARREERAMRKAEKELKRKRKVEQREAEPIAGVSEEVEEFGGSEKEKKEKKKRKRDKETQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHY0</accession>
    <name>A0A1Y1UHY0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair metallo-beta-lactamase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_622733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871635.1">
        <property type="nucleotide sequence ID" value="XM_022015509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHY0"/>
    <dbReference type="FunCoup" id="A0A1Y1UHY0">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHY0"/>
    <dbReference type="GeneID" id="33557318"/>
    <dbReference type="InParanoid" id="A0A1Y1UHY0"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="8">
        <location>
            <begin position="413"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="737"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="903" mass="100854" checksum="4021BE37D3E5810C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI42</accession>
    <name>A0A1Y1UI42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_589583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871720.1">
        <property type="nucleotide sequence ID" value="XM_022013781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI42"/>
    <dbReference type="FunCoup" id="A0A1Y1UI42">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UI42"/>
    <dbReference type="GeneID" id="33555589"/>
    <dbReference type="InParanoid" id="A0A1Y1UI42"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX37733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="476" mass="50968" checksum="244D1F411472694F" modified="2017-08-30" version="1">MTTLAQPSPIAVMDEAGPSTSSTIGLTPLAELVQRSVKRSRAVYSAQDSTTDHGLDEATRIKLATKLAAEFKDVQTLPPVLAAQQAGPAGPKRPAQPAANGGGAGPGVKLIGGPETASSSTSGSAAAAAEPRLLVKFRHQQGFAAEGGHSGSRLSQALMRKKEAREVKPVYHPQWKLTRVISGHMGWVRAVTVDPDNQWFATGAGDRVVKIWDLASGELKLSLTGHISTIRGLGVSDRHPYLFSCAEDKMVKCWDLETNKVIRHYHGHFSGVYSLAVHPTLDVLCTAGRDASVRVWDMRTRANIFTLTGHQSTVADVKTQDSDPQIISGSMDSTVRLWDLAAGKCMTTLTHHKKSVRALAIHPTEYSFASASSGGNNIKKWKCPEGIFVNNFVGHEAIINTLSLNTEGVMFSGADNGTLTMWDYATGLPFQHLKDIPQPGSLDAEAGVFCSTFDKTGTRLITGGADKTIKVYSEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIC0</accession>
    <name>A0A1Y1UIC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 14">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_625548</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 14"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871325.1">
        <property type="nucleotide sequence ID" value="XM_022015813.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UIC0">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIC0"/>
    <dbReference type="GeneID" id="33557622"/>
    <dbReference type="InParanoid" id="A0A1Y1UIC0"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 14" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="810"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="976"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="17">
        <location>
            <begin position="1343"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="274"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="13">
        <location>
            <begin position="1347"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="13">
        <location>
            <begin position="1374"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="13">
        <location>
            <begin position="1494"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="1376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1648" mass="180198" checksum="B1DE4ADE0609E7D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIF6</accession>
    <name>A0A1Y1UIF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_623513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871830.1">
        <property type="nucleotide sequence ID" value="XM_022015593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIF6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIF6"/>
    <dbReference type="GeneID" id="33557402"/>
    <dbReference type="InParanoid" id="A0A1Y1UIF6"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000055">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="4">
        <location>
            <begin position="141"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="508" mass="56388" checksum="93D17243385647C8" modified="2017-08-30" version="1">MRTASTVTRRICRDQLLPAYPVASSSRTLITGPAPTSSSTTPTSAPLPTPTPLPAFQPPPRAPDGRPIYVRGSQAERQERYTRMSSPLRRGTHESWWTADLSFFNAVAKTIPTYRVLDEEGHVVKGGHQPQISKEQALHIYRIMTLVPAVDTIMYQSQRQGRISFYMQGAGEEAATVASSAAMMPNDEFFGQYREQGALLARGFSIKSLMAQCFGNVEDHSTKGRQMPVHYSDPELGWHTITSPLATQLPHAAGAAYAIKLDESRQGDCVICYFGDGAASEGDFHAALGMNSVLGGPCVWFCRNNGFAISTPIIDQYAGDGIASRGPAYGLDTIRVDGNDALAVYEAVQEARARAVEDKKGVLVEAMTYRVGHHSTSDDSSKYRPAEEVKEWMTVDNPIHRFRNFLVQKGWWTEKEDHELIAKHKSEVLAAFKRAEKLPKPKLGEMFTNVWVVKKGDKQPEVMNEQRAELGRLLKKYGDAWGPWRRDRKLFVEEGEDVMDADGFGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIH4</accession>
    <name>A0A1Y1UIH4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871850.1">
        <property type="nucleotide sequence ID" value="XM_022015602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIH4"/>
    <dbReference type="GeneID" id="33557411"/>
    <dbReference type="InParanoid" id="A0A1Y1UIH4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="674" mass="74759" checksum="2E6502E5CDA0A68E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ11</accession>
    <name>A0A1Y1UJ11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_645427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871946.1">
        <property type="nucleotide sequence ID" value="XM_022017612.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJ11"/>
    <dbReference type="GeneID" id="33559421"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ11"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="254"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="572"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="883"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1214"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX37959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1481" mass="164275" checksum="84DE4DA68764B6E9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJB0</accession>
    <name>A0A1Y1UJB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_386418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871571.1">
        <property type="nucleotide sequence ID" value="XM_022012645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJB0"/>
    <dbReference type="GeneID" id="33554453"/>
    <dbReference type="InParanoid" id="A0A1Y1UJB0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="225" mass="24066" checksum="83710BCFA77847B1" modified="2017-08-30" version="1">MIQAEIIICTDQTSSPIEAFGADATSQETIELILREFQDLRPELNSNGIDTQVYTDKINTAVTNWASLAPEQTKASAMDISRGLADVVLSVAKTVNSGTSISRGSILNLGALTNNCLDLLAFDDPSLVRKVDPGRFTHAGLDDASLRPQTNGDNGVSEEGVVDQNELVLRYLVDFKAVANASDGDLSGVPRWEVPTGPDGLRPSWAQTLIATGDRLLQEPEPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJE8</accession>
    <name>A0A1Y1UJE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_619882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872105.1">
        <property type="nucleotide sequence ID" value="XM_022015224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJE8"/>
    <dbReference type="FunCoup" id="A0A1Y1UJE8">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJE8"/>
    <dbReference type="GeneID" id="33557032"/>
    <dbReference type="InParanoid" id="A0A1Y1UJE8"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013141393" description="FAD dependent oxidoreductase domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="387" mass="42580" checksum="6A97CA75F7C63858" modified="2017-08-30" version="1">MSHIVILGAGVVGLTIALESHKRGFKPVIIARDLPQDSDSTGFASPWAGCLWHPFDHEGTTLGSQCDKETFLKLGELSKEIPDLLKRIDVVDLSKDPLNANEMWYNELVGGMREVAASSSKPLPGDFAHGLEWSTYIWDAPRYIRYLGEQVKSKHIPIFKKRLSSLDEAYDLAALESTFAHMDHVDLVINAMGLGSRSLLGVEDPQVYPAKGQTVLVKAPGVERCYMDIGSSFIPGPDDEPYPTIYIVPRPGTSGEVILGGTFLPNDYTPFPDPAQARRILQSAIKIEPKLVKSSSANKNPTWEDIEVISHNVGLRPCREGGPRIELEHRVLGQGWLGPRVHERLVGKKVGVVHAYGFGPAGYQQSLAAARRALDLAEDFCQSRKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJG7</accession>
    <name>A0A1Y1UJG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_619954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872123.1">
        <property type="nucleotide sequence ID" value="XM_022015233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJG7"/>
    <dbReference type="FunCoup" id="A0A1Y1UJG7">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UJG7"/>
    <dbReference type="GeneID" id="33557041"/>
    <dbReference type="InParanoid" id="A0A1Y1UJG7"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX38201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="315" mass="33565" checksum="C36B7DE52AC6A44F" modified="2017-08-30" version="1">MGATRAEKEIYFVKLKALLEQYPSIFLVNVDNVSSQQLHMIRQALRGTGVVLMGKNTMVRRALRTLLAEMPQFEKLLPFVKGNIGFVFTAGDLNTVRQVIVSNKVAAPARAGAVAPNDVFVPAGNTGMEPGKTSFFQALEIPTKIARGTIEIVSDIHLVKAGEKVGASQSTLLNMLNISPFTYGMTVVQIYDNGVVFPPSVLDVEESQLIATFMSGIKTIAAISLATGIPTIASIMHSLVNSYKNVLAVSLATDYEFEGSAKIKEYLANPEAFAVAAAPAAAEGGSAAAADEPAAEAAKEEEEDEDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK57</accession>
    <name>A0A1Y1UK57_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_623520</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871833.1">
        <property type="nucleotide sequence ID" value="XM_022015595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK57"/>
    <dbReference type="FunCoup" id="A0A1Y1UK57">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK57"/>
    <dbReference type="GeneID" id="33557404"/>
    <dbReference type="InParanoid" id="A0A1Y1UK57"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000084">
        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013028064" description="Inactive metallocarboxypeptidase ECM14" evidence="18">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="144"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX37846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="486" mass="54612" checksum="771297B314BD0A04" modified="2017-08-30" version="1">MIAKIIALPTIASLLTSFLAHALPASNPQSPFLASSSRVGPQRFDNEQVWRLNLTALDSADKDNLMNIVKIMDLDVWHASPSQLDVRLDASQTAHLRQVIPSSMPFEPMIPDLQSAIERSSVIHTSLSQETWDVSTIDTPFHDSYHTLDDLYSFGDQLQRYFNGYKGVKIESFVVGTTFQDRQIRGWKASIDTDGGTGNQTFGKKKQELEFVLQSGQHAREWIGPSTALYYLHWLLLAATSGHSPEALLALRTFTFTVVPTINPDGYVYSQEHSRMWRKNRQYLGVDNCVGIDLNANWGYKWRKPQHNNPCAETYAGKAAFEAFETRAMADYLLSANGPAPLYEREGDDEQFNLLKPKSKRIRAFVDLHSYGQLFMYPFAHSCEDFPFDAENLMEASLGVAKAMRQRDGEAYMTGQACDLTYRAPGDSIDFAYGTTDVRWSFSTELRDTGVYGFLLPASYIRPTGEEISAGLTFLAKFIYTTEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKE5</accession>
    <name>A0A1Y1UKE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_363661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872440.1">
        <property type="nucleotide sequence ID" value="XM_022012585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKE5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKE5"/>
    <dbReference type="GeneID" id="33554393"/>
    <dbReference type="InParanoid" id="A0A1Y1UKE5"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="441" mass="48160" checksum="15B6B2669A9CD1ED" modified="2017-08-30" version="1">MYVKSAAVIFTLIMLLSVGSVADRPYWRKGLLIASVLGATISSVGYYFFPQEPFAALPLLTAVIMILSISFNVMTSTCFNGYLGVLARRTEESVSSTILPSTMDIANRDPGVPDHARAADEERRPLLRSSPPGISLRISRLSSTAFAIGLIGSIVCQFVFRKALEAGVSMVTCFAVTGLWTCLTGLPAMILLPARDPIVKDPHGVGYEDSDPVTQKPLRSTTALLRLFKSLGEMSNLRFAMLNWVLASDVCHTMPLVLILQSTDQLAFTPADVTTIALIAMSAGAVSSTLMPHVQAYTRITTKQILLVCTFIAGIQLLMGSSTLLNPHWGYKSRNAVFGTVALVGVGFGGYYSYARALWAELIPKGRETSFFSLYAIADRSASFFGPLMVAAITQSTGRFDYAWFLLLIMMLLSIPPLLWVNVEQGKIEADRYLEKEEHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKJ7</accession>
    <name>A0A1Y1UKJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_577633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872493.1">
        <property type="nucleotide sequence ID" value="XM_022013271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKJ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKJ7"/>
    <dbReference type="GeneID" id="33555079"/>
    <dbReference type="InParanoid" id="A0A1Y1UKJ7"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="699" mass="75088" checksum="8827AA048100ACE4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKL4</accession>
    <name>A0A1Y1UKL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_649877</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872434.1">
        <property type="nucleotide sequence ID" value="XM_022018057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKL4"/>
    <dbReference type="FunCoup" id="A0A1Y1UKL4">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKL4"/>
    <dbReference type="GeneID" id="33559866"/>
    <dbReference type="InParanoid" id="A0A1Y1UKL4"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX38512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="509" mass="55469" checksum="097B8380AACAB54D" modified="2017-08-30" version="1">MRPRSIYQLITDRFALPNGTTSSCGTAPSGLYCGGTYTGIISELDYIQGMGFDTIWISPVVENIGGMTQYGEAYHGYWTLNPDNLNDHFGTADELKSLSKALHDRGMYLMVDIVINHVAATSSSGFVPNPAYGPFSKHSDYHSFCWVKDYNNQTNVEDCWLGDSEVALPDLNTESQHVIDYWYDWVPKLVSNYSIDALRIDTVKHVDMAFWPGFTQAAGVYSVGEVWNGDAKYVGAYQKEGKVNPLNYPIYDPLVKAFQGSDGSMDDLVSGIAQVKDNFVDPTLSGVFLNNQDNPRFESYTQDTSLRKNAEAYALIGDGIPIVYYGSEAGFNGGNDPDNREPFWPAGYKTDTDMYGFFKSLNAARSAAGAASSSFYTTQMSVSALSDNEILIVKGSLVSVLSNRGSSGSTALVLPSKSTSFPPSAHVVDAVSCDSMTTDQDGDLNLPITNGLPRVLLLAEHQGPKVCPGGTNELSTLESKSILNRNLPGHLPILNFLSLGIIGFILTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMA6</accession>
    <name>A0A1Y1UMA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Mtochondrial processing peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_608058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872579.1">
        <property type="nucleotide sequence ID" value="XM_022014098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMA6"/>
    <dbReference type="FunCoup" id="A0A1Y1UMA6">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMA6"/>
    <dbReference type="GeneID" id="33555906"/>
    <dbReference type="InParanoid" id="A0A1Y1UMA6"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="214"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="530" mass="58393" checksum="D64D1795AD8ECE41" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMD2</accession>
    <name>A0A1Y1UMD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell differentiation protein rcd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_618868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873081.1">
        <property type="nucleotide sequence ID" value="XM_022015090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMD2"/>
    <dbReference type="FunCoup" id="A0A1Y1UMD2">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMD2"/>
    <dbReference type="GeneID" id="33556898"/>
    <dbReference type="InParanoid" id="A0A1Y1UMD2"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33565" checksum="2554086FDC9F073D" modified="2017-08-30" version="1">MSSVLGQGSGAPGGAGKLLLLPSGSAPPAGSEEEKIYMLITELLDPETRETALLELSKKREMYEDLALVLWGGFGIMSSLLLEIVNVYPALSPPSLTAHASNRVCNALALLQCVASHSETRSLFLNAHIPLFLYPFLNTTSKTRPFEYLRLTSLGVIGALVKQNENSDVINFLLSTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDLGLQYICQTYERFYAVGAVLANMVQALVESQAVRLLKHVVRCYLRMSDNPRAREALRACLPEALKDNTFAGLLKGDMVTRRCLSTLLHNLNERPTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN17</accession>
    <name>A0A1Y1UN17_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_333023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873313.1">
        <property type="nucleotide sequence ID" value="XM_022012512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN17"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN17"/>
    <dbReference type="GeneID" id="33554320"/>
    <dbReference type="InParanoid" id="A0A1Y1UN17"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="85"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX39450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="574" mass="62748" checksum="BBB60DFA98E34C0B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNB0</accession>
    <name>A0A1Y1UNB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-fucose protein O-fucosyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_649072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872837.1">
        <property type="nucleotide sequence ID" value="XM_022017932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNB0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNB0"/>
    <dbReference type="GeneID" id="33559741"/>
    <dbReference type="InParanoid" id="A0A1Y1UNB0"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53757" checksum="A60F3F70173E8E8A" modified="2017-08-30" version="1">MRITFPNPLGPPISFDTANIPSGPPILSRLTSHPRRAQIRVLLLILISLLLLSWRPSPPFPPDYAREWSLERTLPKSYNRPLIEGKEGRYIKFESPKPTGFNHQMQRVLLQHHLAVLSNRSYAYEPLVQDDTRFPFVLTFPPWRSARVPLSALISTVTSGFERFFDNPRAVPYSHYRSICPSWKETVYQLKDADHPDGNLDVSLDAQMRVHQLQALFAGNDAKCLRIQGPVFGDDFFDSESLLQLQQSFIQSPVLQHFTMSPTVLSVVNREMHRLAPDSAPYDLTRVGTAFTAEGVRPGSNWKHILALHLRHGDSWSQTCHDKGMKSAPFVGWTKIPEFPGNENVPPPADMAEAARLGLYKAKCSPDTLDIIARARRMRKNHPFLHTVYILTDGVTPWGEEVKMWLLSEGWENVWLSPKDIWPDWQDGEIGVGVDMEVARRSGVFVGNGFSTTGSNIALLRLRDGIHPDLTQFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNR9</accession>
    <name>A0A1Y1UNR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_575430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873475.1">
        <property type="nucleotide sequence ID" value="XM_022013126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNR9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNR9"/>
    <dbReference type="GeneID" id="33554934"/>
    <dbReference type="InParanoid" id="A0A1Y1UNR9"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46019" checksum="E30CBCDAC4602D75" modified="2017-08-30" version="1">MSSGQASSLPPKGMPILSGPPPIVETAECRRCNKEFNPLWRRAHSCGHCGYQYCSTCLSDGQALMPRKPGASSTSTNPFTAIKEELGFSEKKSTMSGYDVESVCLNCLSMLQVTAAPLNILRSLPLKRLKGYLEAYNIECVGPKEKEDFVQAVLKARNPTTGCLSPEAESYYRRKSVPKGNAGPSFRPPPPQSNGQSMHSTQPFQSRPPPPPPQQYRPPPPTSSRPAPATPTSTGPSPARPRAANQPAPPKPAQPPPPVPTLYSLVSLPLSYLSSLSIGTLKAILYENHVRVDFSQVLEKGELVKRVSELVTDERKRLERQAREEQLEAEGRSAEAREASPAPDGSTGEKEARQVPTGPTPDMDHDRCVVCQDEQATLAAVDCGHLAMCSHCSDLIMATSRECPLCRTRIVTPQRLIRIYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPX5</accession>
    <name>A0A1Y1UPX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_576261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873858.1">
        <property type="nucleotide sequence ID" value="XM_022013181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPX5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPX5"/>
    <dbReference type="GeneID" id="33554989"/>
    <dbReference type="InParanoid" id="A0A1Y1UPX5"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="400" mass="45652" checksum="2E363E07E4A9FA52" modified="2017-08-30" version="1">MGPSSKPFGNPPQKPTFPIHNLNVHFPQSDIDDLRSRLNNARPLRTTWENSFTDAALGIRQDWMDQAIAYWRNKYDWREVEEKINKYPNYMASLKAREHEQSIHFTALFSEKTDAVPVLMLHGWPGSFLEFQPLMDDLVSNYSPSDLPIHLICPSHTGYGLSGPPPRHDKFTKRDAAELYDGLMRGLGFDSYVVQAGDFGALIARLMAENFDGCKAIHLNRLHLERPETRDIAPTTKEEEKAVAEAKEWNLYEAAYKREQVTKPATIGIVASSDPVAMLAWIGEKFLAWSDETPSLDMILSNVTLYWLTESFPTGLWAYNDDHPPVAVKGTSPHNKHEKPVGYSLFPKDHETYPESYVKKAMNLVWFRQHDKGGHFAALECPKVLLQDLLDFVKEVWSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQA0</accession>
    <name>A0A1Y1UQA0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_597882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873988.1">
        <property type="nucleotide sequence ID" value="XM_022013885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQA0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQA0"/>
    <dbReference type="GeneID" id="33555693"/>
    <dbReference type="InParanoid" id="A0A1Y1UQA0"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="306" mass="34341" checksum="C33538C2EA46CB1A" modified="2017-08-30" version="1">MGAFDGLRRGQATHGYWGKHTSSIDWCEINYEHTPYVAEFINTITNVPVISAGIYGAIATVRGGVAKRYSLLYLGLSLIGIGSFGFHASLRWEWQLLDELPMIYVVSFATYLVWDTRPTFDFLFGIFGPLLVIAWCLFVTFSYIYLPNPIYHQVAFAFILLSAVTRNAVLLRRIPSTHPSRKLIGKTLLKGSLIFAIGFGIWNLDNIFCSEFRSTRDALYPYAIWLDGHGIWHLMTGYGSLLIFAAAIYLSLAIKTSPDTYAFDGDAWFPIVKAKTPSERSSKDSKIKLDQAKSPIPIDEKQAIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQD4</accession>
    <name>A0A1Y1UQD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycogen synthase kinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_640882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873451.1">
        <property type="nucleotide sequence ID" value="XM_022017380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQD4"/>
    <dbReference type="FunCoup" id="A0A1Y1UQD4">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQD4"/>
    <dbReference type="GeneID" id="33559189"/>
    <dbReference type="InParanoid" id="A0A1Y1UQD4"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="406" mass="45513" checksum="7C945E7463BEA2C3" modified="2017-08-30" version="1">MSGVVNGVKVSPDDPQRVTTVTACAGKSGKEILIQYTGAKVAGNGSFGVVFAAKTLPGKDENGNDVPEQEIAIKKVLQDKRFKNRELQIMRSVAHPNVVDLKAYFYSNGDKKEEVFLNLVLEFVPETVFKASKHYSKMKQPMPWPQVKLYMYQVLRSLAYIHSVGICHRDIKPQNLLLDPSSGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATNYTTYIDIWSTGCVMAELMLSTPLFPGESGIDQLVEIIKVLGTPTREQIKTMNPNYMEHKFPQIKPHPFTKVFRPRTPADAISLIDQLLQYTPTSRLTAPEALVHEFFDDLRQPDTQLPNGKPMPPLFNFTREELSLRPDLIRQLVPPHAEASLRERGIDVDNFQPIPLDQLRISLDVSGSRGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQS8</accession>
    <name>A0A1Y1UQS8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873609.1">
        <property type="nucleotide sequence ID" value="XM_022014686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQS8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQS8"/>
    <dbReference type="GeneID" id="33556494"/>
    <dbReference type="InParanoid" id="A0A1Y1UQS8"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="369" mass="39989" checksum="BD969EDF3F0F2DA4" modified="2017-08-30" version="1">MSIEPVRISYQILRSSPHTAAEDIQQAFGSDEGCLGIILVDDLPEQFTALREKLFRLAQVFATASEDVRESLVRPETSYSFGWSHGKEVMNGRPDTQKGSYYANPMLDVPNVSDAQRQAHPEYYAGNVWPRDVPGLEDFEKTFKALGALIFEVGCALATACESFVASNVASGSKSTVQSLIANSKTNKARLLHYFPETASSSSSSSTTSSDSPSDGQRIANDALCGTHVDHSLLTGLCSAMYLSTETGSPQIVSAPTPTAGLWIYPRHRTGTPRPDPVKVAIPQHCLAFQTGEALEILTSHRLAATPHFVSGSSGGSPQAQYISRETFAFFLQPDVDDVIGPDGETFGAFTKRVLGRHYQDQAFKEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URB6</accession>
    <name>A0A1Y1URB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_611413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874269.1">
        <property type="nucleotide sequence ID" value="XM_022014264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URB6"/>
    <dbReference type="STRING" id="4999.A0A1Y1URB6"/>
    <dbReference type="GeneID" id="33556072"/>
    <dbReference type="InParanoid" id="A0A1Y1URB6"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44796" checksum="F7FD6CE4FF317848" modified="2017-08-30" version="1">MTSPRPFRAGLGLPEAVVIRSGPVSASHLADQHYEPTDRQSWKEWTVNPAKHGPERLTRAPVFLPSKQQYDDLGRSLGDGVGIEVDQGDVKVPREVDDGDRVSAWYTQLASRPTTGSSTPGSGPSDLRPKGPPAIVDLTDLDDEDEDELKMEPPSTIEAEPLRVNRNEWYIRRALLRRCQLEGAPRRPLVQSKPSSIGRLVEIDLTKPLPAQPVHYVLGPENKGYAMLKDRLGWEGGGLGRPVGWLEPTTLDCFRQMPEAGPSRLASQLKAEIEEDAESQIRQREAGAAETIVDLTAASDGEDDDFDEDAAEPPRQGGPGRTAPIATALKLDRLGIGHIRSTRPGNPESVKKVTHTAKEIAQARQRAKYAGKPMSKLELGKKGKMKWSEKEKREREHRQRLAAAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URH4</accession>
    <name>A0A1Y1URH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_616871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873992.1">
        <property type="nucleotide sequence ID" value="XM_022014860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URH4"/>
    <dbReference type="GeneID" id="33556668"/>
    <dbReference type="InParanoid" id="A0A1Y1URH4"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="74" mass="8083" checksum="3B80F9CE1A92D686" modified="2017-08-30" version="1">MSMGSSDEMTVVSARACDGCRRMKIKCVGREHPPCQRCKSMSLACTVGEAAPLPFKPRLAAEQVQDDSSWSDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URL1</accession>
    <name>A0A1Y1URL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873919.1">
        <property type="nucleotide sequence ID" value="XM_022017875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URL1"/>
    <dbReference type="STRING" id="4999.A0A1Y1URL1"/>
    <dbReference type="GeneID" id="33559684"/>
    <dbReference type="InParanoid" id="A0A1Y1URL1"/>
    <dbReference type="OrthoDB" id="2562172at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="478" mass="53976" checksum="C464789C6F9903BF" modified="2017-08-30" version="1">MSSPLLGTPRVMPRARSGRRLQQVFVYGGICFCIFLLVHRLRESDREQLVQPMSIISPYAFAPRNWNAQSYLHYSPDSAVDFHHGWSESAPSSPLSSSQKKESLPDVHLLLPVNKVAARRGDRFCKTAIGAIMTGYKPFVYNWGGEAANIGKTHRQKVSVLRDILRTTATGWREDDLIFVIDALDVWLQLPPADVARRFAQFDQDLVYVGAEKHCAPNPWDSPECRNAPESPLPKNLWDLKTMKPASNEHSSLARHANSGTILGRKDRMAETLTELASILEAEDYGYAGDQASFNQLLGKGGRRLGVDYYHRLFWPSAADDQNMHFINTPVHPDHHLLRGPDDLHSVTGAPINPRDDIIPWDSYPAMGHHQLTGQVPIALHFNGYRGKDLVNEWWGIPWYSAERFRAMAKEKMADATISVMKRDGTISEDIPIRDICWDLTKDFFDGMPDNWVDPTGKLVRSGKIDESLHEEDVDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URQ3</accession>
    <name>A0A1Y1URQ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_259195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873901.1">
        <property type="nucleotide sequence ID" value="XM_022012305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URQ3"/>
    <dbReference type="GeneID" id="33554113"/>
    <dbReference type="InParanoid" id="A0A1Y1URQ3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="165" mass="19332" checksum="AD1074636F3B386C" modified="2017-08-30" version="1">MIRYRSSRAPRPVCFYLWHFSSTVTTCHDLLLSYRRCLRECQIRSATDHRLVWSEQSMNHPLRAGIRNETDGKATYLPEKANCSSPYFRMRYDERRSDHPDTATCSLRRTVPGGMQRLQPAGHDIQTYIYTIGWTSSMRPIWRICCALSTYSKVRTISVVFLSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URT3</accession>
    <name>A0A1Y1URT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874437.1">
        <property type="nucleotide sequence ID" value="XM_022014334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URT3"/>
    <dbReference type="FunCoup" id="A0A1Y1URT3">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URT3"/>
    <dbReference type="GeneID" id="33556142"/>
    <dbReference type="InParanoid" id="A0A1Y1URT3"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="231" mass="26254" checksum="8648CADE64D30AD6" modified="2017-08-30" version="1">MSGPPSPTLSDSALLDSLDDDPRFDIAADRDRRMEKLKEEVEKVKQLQESDYRKVVTFTDERKLIERMSKDKYCILHFFHPDFQRCQIMDRRLEELAPKHPYTLFIRASVADIPFLVTKFNIKVLPCVLVFADSRCVDQLVGFEEFGNSDHFSAKALEFRLKESGALPEGKPTLVNTLSSSLLDPHSRIKDDSDDESDGDETAARRSRGTGPRRGKTGIRNGLLTGMDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US45</accession>
    <name>A0A1Y1US45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_612310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874530.1">
        <property type="nucleotide sequence ID" value="XM_022014380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US45"/>
    <dbReference type="STRING" id="4999.A0A1Y1US45"/>
    <dbReference type="GeneID" id="33556188"/>
    <dbReference type="InParanoid" id="A0A1Y1US45"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011965592" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="847"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="915" mass="98035" checksum="46488A7A7AD9643D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USH4</accession>
    <name>A0A1Y1USH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_612729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874649.1">
        <property type="nucleotide sequence ID" value="XM_022014431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USH4"/>
    <dbReference type="STRING" id="4999.A0A1Y1USH4"/>
    <dbReference type="GeneID" id="33556239"/>
    <dbReference type="InParanoid" id="A0A1Y1USH4"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="307" mass="33452" checksum="A66BC00E7E9AD94A" modified="2017-08-30" version="1">MSTDLNLQAILAFAIDVALEAGKMIKDGQAKRFAAGAGMDEKANAVDFVTEVDKAVEAFITERIHSQYPEFKFIGEETYDGQQITDEPTWIVDPIDGTTNFIHGYPMVATSIGLAVKGIPVLGVVYNPFTDYLYSAAKGHGAYLNRTTKLPFTGRPMPLESLSQALIGVEYGSKREEPSMSRKSKVFHTLAAHPSLGGKHCHSMRLCGSAALNGCLVATGGLDIYWEIGCWPWDVCAASCIITEAGGAIFGSKDKMDSWNGEANAEFMMERKYLFVRAISAAEGESAFEAQKKIANELLDIVEEWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USI7</accession>
    <name>A0A1Y1USI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_612681</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874638.1">
        <property type="nucleotide sequence ID" value="XM_022014423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USI7"/>
    <dbReference type="FunCoup" id="A0A1Y1USI7">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USI7"/>
    <dbReference type="GeneID" id="33556231"/>
    <dbReference type="InParanoid" id="A0A1Y1USI7"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="364" mass="39883" checksum="C9B0CA6363849274" modified="2017-08-30" version="1">MKALILVGGFGTRLRPLTLSWPKPLVDFCNKAMILHQIEALVKAGVKDIVLAVNYRPEVMVSVLKKTEEEFGIKITFSVETEPLGTAGPLALARDILGKDDSPFFVLNSDVTCTYPFEAFRDFHLSHKCEGSIMVTKVAEPSAYGVVVTKPGSTAIDRFVEKPVEFVGNRINAGIYMFNPSVLDRIELRPTSIEKEIFPQIAADGQLHSYDLAGFWMDVGQPKDYITGTCLFLSHLTSQHSPLLSDPSKNKWVYGGNVLVDPTAEIDPTAVIGPNVVIGQGVKIGPGVRLQRCVILSNAVVRDHAWIANSIVGWNSNVGRWVRVENITVLGDDVTIKDELYVNGASVLPHKSISSSITEPRIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USV8</accession>
    <name>A0A1Y1USV8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_574669</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874779.1">
        <property type="nucleotide sequence ID" value="XM_022013077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USV8"/>
    <dbReference type="STRING" id="4999.A0A1Y1USV8"/>
    <dbReference type="GeneID" id="33554885"/>
    <dbReference type="InParanoid" id="A0A1Y1USV8"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000433">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX41100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="312" mass="34621" checksum="D1917C1BFB43D699" modified="2017-08-30" version="1">MDEIEVIGEVGRGNYGSVQQVYHRPTGVTMAMKEIRLELDESKLNGIIMELDILHRAALSPEIVEFYGAFTIESCVYYCMEYMDASLDILTGGGRPAKVGEKDPDDESQELRVPEPVLRRITLQMIKGLKFLKDELQIMHRDVKPTNVLMNRKGEVKLCDFGVSGQLEKSLAKTNIGCQSYMAPERIKGESQNQLSTYTVSSDVWSAGLSIVELARGCYPYPPETFANVFAQLTAIVHGAAPRLPKGYSEDAHDFVAKCLTKDPNGRPTYAQLLEHPFLLADKDSDVDMAGWVAQALERRAVRGGTQVPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USZ0</accession>
    <name>A0A1Y1USZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_678089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874323.1">
        <property type="nucleotide sequence ID" value="XM_022018973.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USZ0"/>
    <dbReference type="GeneID" id="33560782"/>
    <dbReference type="InParanoid" id="A0A1Y1USZ0"/>
    <dbReference type="OrthoDB" id="10255344at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="210"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="394"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="815"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="914"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1301" mass="144349" checksum="B041941A6AF22C88" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE2</accession>
    <name>A0A1Y1UTE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Pre-mRNA-splicing factor RSE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_648162</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874967.1">
        <property type="nucleotide sequence ID" value="XM_022017796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTE2"/>
    <dbReference type="FunCoup" id="A0A1Y1UTE2">
        <property type="interactions" value="1087"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTE2"/>
    <dbReference type="GeneID" id="33559605"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE2"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="14">
        <location>
            <begin position="13"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="15">
        <location>
            <begin position="466"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="13">
        <location>
            <begin position="862"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX41288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1217" mass="133604" checksum="070861088EA2E0FF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE7</accession>
    <name>A0A1Y1UTE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonyl/alanyl tRNA synthetase SAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_56147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874978.1">
        <property type="nucleotide sequence ID" value="XM_022013018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTE7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTE7"/>
    <dbReference type="GeneID" id="33554826"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE7"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX41299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59025" checksum="4A0384A91DB04B6F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTX9</accession>
    <name>A0A1Y1UTX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_596201</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874324.1">
        <property type="nucleotide sequence ID" value="XM_022013861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTX9"/>
    <dbReference type="FunCoup" id="A0A1Y1UTX9">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTX9"/>
    <dbReference type="GeneID" id="33555669"/>
    <dbReference type="InParanoid" id="A0A1Y1UTX9"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000002">
        <property type="entry name" value="Transcription elongation factor SPT4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010995530" description="Transcription elongation factor SPT4" evidence="15">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="16">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX40645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="114" mass="12724" checksum="8FAEDE7CB2E0A383" modified="2017-08-30" version="1">MPPKGKRNDLRACLVCSILQTANGFLTQGCPNCEDILEMRGSADRVAECTSIQYDGMIAMIEPEESWVARWQRIDKRARGLYAVRVTGRPPPDVIDAIESRGGVYRPRDAVDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUQ8</accession>
    <name>A0A1Y1UUQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_28917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874614.1">
        <property type="nucleotide sequence ID" value="XM_022012390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUQ8"/>
    <dbReference type="FunCoup" id="A0A1Y1UUQ8">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUQ8"/>
    <dbReference type="GeneID" id="33554198"/>
    <dbReference type="InParanoid" id="A0A1Y1UUQ8"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF40">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="165"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="441" mass="47177" checksum="FF32B158852A70D8" modified="2017-08-30" version="1">MGAEYQPPPRRTAPAPAASTPSPEKKSWKDKMRAAGKTAVDKGMVISDKVGGRVNDIAEKRLGTERFWPTTGDFPQEMEKAARILTSFTVDGVVTEVKDESKLGKKVKMLRKIPAKVFKDCKGVAIFTAMRTGIAPLGGAGGAGIVIAKLEDGSWSAPASITPNNLSTGFLIGVDVYDCVLIIRDQKALDSFRTHKFTLGAEIGVAAGPYGGGRAVEAGIEKAPVLSYVRSKGMYAGVELVGQVFVERFDENANMYHWPGVKAGDILAGKVKVPQEAGNLIMALMEAESGRAQQETGAMDVMIGAGPHGEDVPVDDEGVDVDEEKGEMEHGNPEGKPPVLPPREPALSLQPPPLHPSRNPTGELMRPPLGTQHSSASHYSDMNEAEPAPPLDQVREVSARMDGTHINGFDEKNGHAKENDVGAVYRQEGEAPPPEYDESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUY7</accession>
    <name>A0A1Y1UUY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_54721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874965.1">
        <property type="nucleotide sequence ID" value="XM_022013014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUY7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUY7"/>
    <dbReference type="GeneID" id="33554822"/>
    <dbReference type="InParanoid" id="A0A1Y1UUY7"/>
    <dbReference type="OrthoDB" id="5426988at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX41286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22139" checksum="A8F639A68DC0F2A1" modified="2017-08-30" version="1">MSNAVILINGFPGVGKSSVARELMALLPHSTLLEAQALDLAANAAHEVTSRSNAELRKRLRETILRSLAPVGTGVGAQSRIMVITDTLLSSPPTSAFLQSYLACCRSNGIILIHIILSCDSSTNVSRLGSGSKIDEDTLVAMRMEEEIGQYLSLQDKVRGGSMPGLSGEMELDNSNLGAKDTAARVGEYCIDLLKRQGWSLQPAKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6I6</accession>
    <name>A0A1Y1U6I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_639051</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867963.1">
        <property type="nucleotide sequence ID" value="XM_022017187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6I6"/>
    <dbReference type="FunCoup" id="A0A1Y1U6I6">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6I6"/>
    <dbReference type="GeneID" id="33558996"/>
    <dbReference type="InParanoid" id="A0A1Y1U6I6"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000097">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="10">
        <location>
            <begin position="72"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="865"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112757" checksum="97F0DA259BBD64C6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6N1</accession>
    <name>A0A1Y1U6N1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium activated cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_639164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868001.1">
        <property type="nucleotide sequence ID" value="XM_022017197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6N1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U6N1"/>
    <dbReference type="GeneID" id="33559006"/>
    <dbReference type="InParanoid" id="A0A1Y1U6N1"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="5">
        <location>
            <begin position="254"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="634" mass="72056" checksum="17BFF6C0D9B9A7E0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6S0</accession>
    <name>A0A1Y1U6S0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Triose-phosphate transporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868029.1">
        <property type="nucleotide sequence ID" value="XM_022013695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6S0"/>
    <dbReference type="FunCoup" id="A0A1Y1U6S0">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6S0"/>
    <dbReference type="GeneID" id="33555503"/>
    <dbReference type="InParanoid" id="A0A1Y1U6S0"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="456" mass="50791" checksum="4849F5E7F8B15016" modified="2017-08-30" version="1">MDRSDAASIATVDQKKALWWRDVLITGLFIASWYGFATLLSLYNKWMFTPKYYNFPYPLFVTTCHFFIQFLLAAAILNIWPKRFKPVERPTRKDYVSKIFPAALSTGGDIGLSNLSLKIITLSLYTMAKSSTLLFVLFFAFVFQIEKPSVRLVAVIFLISFGVFLMVFNTTSVSIPGLVMVFSASALAGLRWALTELVMHKKSMGLGNPFATLYWLAPLMALSLGIVSMGAEGWFKVLGSEHLQGTKAIFTIGVIVFPGFLAFAMVSSEFFIIHRAGSVPLSIAGIFKEVTTITISALVFGDELTELNMIGVAITVCGICVYTYHKYQRSMKQTVSLDSRGQPVGSPGHSGESGSAYAHDSEHQPLTTTSPSGYTRVQLHPVRTPRSSETRDERTQRLRDDFEGWNDREDWSDDEHEGSTGEAGEDEVARLRAERDGKVVDDVQPAGWGPWWDQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7L1</accession>
    <name>A0A1Y1U7L1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868290.1">
        <property type="nucleotide sequence ID" value="XM_022017064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7L1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7L1"/>
    <dbReference type="GeneID" id="33558873"/>
    <dbReference type="InParanoid" id="A0A1Y1U7L1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="303" mass="33881" checksum="8D4982E6EA2F80CD" modified="2017-08-30" version="1">MSRNPQPIESLLLPLKPESLQCIHRFMEYERVKETRRFPKNRTAAVAIILFIGRLGDLYVLLSTRAEAMRTFAKDTALPGGKYEPGDKDEEATARREAFEEIGLPIGYERVRCLCLLDPFLTGIGLIVTPVVLLVTDNAINPVLNPSEVSYLFSMPLSAFLHDHPSRIPGWHFGISSRVDPGPFYSPPPIVEYADDAGEVGGKEGRYYGYRDVRWGPGIVRMHRFLTGREADGIKPVFGLTSAILIRAAMIGYDTQPAFKVHAPGQASMLERIEWEIRNGTGPLRQAVLDDGLMDDWAIRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7S5</accession>
    <name>A0A1Y1U7S5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis, uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_639452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867913.1">
        <property type="nucleotide sequence ID" value="XM_022017231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7S5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7S5"/>
    <dbReference type="GeneID" id="33559040"/>
    <dbReference type="InParanoid" id="A0A1Y1U7S5"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="272" mass="29988" checksum="F83E910856EA8D4E" modified="2017-08-30" version="1">MTTTSPTSRKVYLFRKPSIPDAYLDAFRSAFFDPECISVLQEIYELEELATVVNQGGQSYDAVVISSKRGAEGWVRAAEQARQMKTSWSTTPLYAVGKSTFDVLTSTSYSDPASALPSLSEYRIAKSGSALVDLIRRDDTGRPPTGHWLIVRGDKSNEEVANGLRGMGKRVTEVIVYRTLEDPDLRSSLHALHSGWLVFFAPSSAEMVLAHLSQRQELSPRAGAASSRYRIAAIGQTTRKFLEDRGYRVDAVADEPTAYGLLHSVKDASTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Z5</accession>
    <name>A0A1Y1U7Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868410.1">
        <property type="nucleotide sequence ID" value="XM_022016931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Z5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Z5"/>
    <dbReference type="GeneID" id="33558740"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Z5"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="233" mass="26297" checksum="5FCDF65CEA585EBE" modified="2017-08-30" version="1">MTPMAAADELWAKLLQDAEALAKEHMSGYDPSHDWAHVQRVRQWAMHLATTVEGPIDRHVVELCALFHDVCDAKYSDTPLPSILGPFFDAHPGVMSESQLDLIYRVIPSVSWSTEVKLRASHQWTEWHDQSRELAVVQDADRLDAVGAVGVMRCAAYSSSKNVLLLDPKESMKVHANGSKPVPTAQAHFHEKLLHIKDRMKTRAGRIEAEKRHQTMLDFLDALSREQDTTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U847</accession>
    <name>A0A1Y1U847_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YKOF-related family domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_172050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868488.1">
        <property type="nucleotide sequence ID" value="XM_022012090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U847"/>
    <dbReference type="GeneID" id="33553898"/>
    <dbReference type="InParanoid" id="A0A1Y1U847"/>
    <dbReference type="OrthoDB" id="5173070at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011522">
        <property type="entry name" value="Thiamin/HMP-bd_put_YkoF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07615">
        <property type="entry name" value="Ykof"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamin/hydroxymethyl pyrimidine-binding YkoF putative" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamin/hydroxymethyl pyrimidine-binding YkoF putative" evidence="2">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="206" mass="22257" checksum="C0F2A4168B8F4C56" modified="2017-08-30" version="1">MYCGAQVTLSVMSDDYVAVILGALSSLDPYRKDLRMETDDTSTLMIGPPDILFAAMRDLFTLVVKSGHHVTMHALVSRGCPGGPQLPETRSEPGSTPPPLPLSTRKQNALVAVETASETGQIISAQFAYYPLGQPPGYMTEINACIDFIDESGTLDRKKNFCTKLRGDGAKVFKTLEGVFVSFAPDDAHITLDLMLSANSPTARDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U877</accession>
    <name>A0A1Y1U877_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_174000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868519.1">
        <property type="nucleotide sequence ID" value="XM_022012096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U877"/>
    <dbReference type="GeneID" id="33553904"/>
    <dbReference type="InParanoid" id="A0A1Y1U877"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="179" mass="20095" checksum="CCC99648E04EACE7" modified="2017-08-30" version="1">MTEHDEKWRCIACSIASAPESAPTHENAAEVKTRINSMELLQRNLTVSPLTRVTEPSTWRESESDMIHRIRRGLESVLDDQAHLSSLDPSNDHRIGLAGHSRQGSILMQKILGLYPGLSQAKSKLQHGETRKLLFKYRLQDGLTPLPSTWSKASQNGLQSKSTERAVLRTLDSNTLRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8G6</accession>
    <name>A0A1Y1U8G6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_637494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868591.1">
        <property type="nucleotide sequence ID" value="XM_022017016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8G6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8G6"/>
    <dbReference type="GeneID" id="33558825"/>
    <dbReference type="InParanoid" id="A0A1Y1U8G6"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="608" mass="65588" checksum="E0F96FF8AD9C9353" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8Q2</accession>
    <name>A0A1Y1U8Q2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_643636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868212.1">
        <property type="nucleotide sequence ID" value="XM_022017559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8Q2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8Q2"/>
    <dbReference type="GeneID" id="33559368"/>
    <dbReference type="InParanoid" id="A0A1Y1U8Q2"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="262" mass="30740" checksum="693BD05DE5E9E863" modified="2017-08-30" version="1">MPRHPDEDNHPVATGLAKKLVDAHQARQDLVFWSAWFCPFNQRIWMALEERNIPYQYHEVNPYKKEKDFLEVNPLGLVPALTDKGRALYESDVLVEYLEDKYPPSKEHPPIFPTDIYEKSWARINIQHITKDIIPHYFKLQQAQETEDQQQALEEFYKGLRTLVDRVKLPYFAGEQFTAVDMSLAPFVRRFYSLEEHRGFDGEKALGSKWVQDCHADIFSERESLKNTTSEKEYYAPLLERYLKDEAQSEVAKATRSGKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8S6</accession>
    <name>A0A1Y1U8S6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_653189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868675.1">
        <property type="nucleotide sequence ID" value="XM_022018625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8S6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8S6"/>
    <dbReference type="GeneID" id="33560434"/>
    <dbReference type="InParanoid" id="A0A1Y1U8S6"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="579"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1170" mass="127854" checksum="A51953889B278986" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U947</accession>
    <name>A0A1Y1U947_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868814.1">
        <property type="nucleotide sequence ID" value="XM_022016890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U947"/>
    <dbReference type="GeneID" id="33558699"/>
    <dbReference type="InParanoid" id="A0A1Y1U947"/>
    <dbReference type="OrthoDB" id="2564568at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012485824" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="21430" checksum="943E8DE67204D0C8" modified="2017-08-30" version="1">MLFNFALLSILGAIGASAANHHAVRSLLARQQSLNPSDIPSACQSDCQSTLTIYSACENNDESTCLSICSSSNFSSFRSCLSCILQDNPDASNDNVEAVNQALDQLEQLCDSVGSTVSAADFSATFTGSDAASATGTSTGSTTATTTSAGVIASLSQAASAIVSGASSAAGAAQSGASSVAGAASSAAATTSGAANVAASLPNFAGVAVALVGVVAGAAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9D0</accession>
    <name>A0A1Y1U9D0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phox homologous domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_634308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868881.1">
        <property type="nucleotide sequence ID" value="XM_022016711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9D0"/>
    <dbReference type="FunCoup" id="A0A1Y1U9D0">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9D0"/>
    <dbReference type="GeneID" id="33558520"/>
    <dbReference type="InParanoid" id="A0A1Y1U9D0"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="297"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="357" mass="39542" checksum="97C12C8ECC203665" modified="2017-08-30" version="1">MSEIQSISIVSTQTVAQPKPHTTYTVQVTTPMRSWTVSRRYNDFVALNDELLSSTGKAPPAALPPKHPWSITRSAYDQKVIRERKVLLEAYLRAILNHRDPRWRSSYTYLDFLAAPAASSSSVPTSWTPSNWLSEHTNIQAQLRTARSALLKRDALAGMGDAPGSRGASVEAKKMLRDVGERIDALSQALGDISKSIGEGERKRREEMIEGLKNERGDLQRMADAGVRTIRDMAPKAGETSGFGAGSRNMPGSIPNGSGAVGPAPGRVFGRQPPPEETSETRPLDDRGLLQLQQTKMDDQDSQLEELSKILRRQRNMGEDIDREIRDQNEILDEIQTDVDKVGGKMARAKRQLNKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAA1</accession>
    <name>A0A1Y1UAA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_662098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869174.1">
        <property type="nucleotide sequence ID" value="XM_022018900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAA1"/>
    <dbReference type="FunCoup" id="A0A1Y1UAA1">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAA1"/>
    <dbReference type="GeneID" id="33560709"/>
    <dbReference type="InParanoid" id="A0A1Y1UAA1"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017422">
        <property type="entry name" value="WDR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038169">
        <property type="entry name" value="WD_repeat_p55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="374" mass="41710" checksum="B0996AFFB0C41B85" modified="2017-08-30" version="1">MPQSRIREVWKTFQTSLIMPDIKLKNQPFDLSFHPTEPVLYASLLTGEVKAFQYDDTTGESSGSASWSVRPTKRTARAVDCSEDGTRLWMGGKAGGLFELDPKDGALKSERLEAHESPINRVYSINEQLLATGDDDGVIKFWDPRQEESIRSYSQHFDYISDFCFFGDKKQLVTTSGDGHISVIDIRSNKATPLQVSDDQEDELLSVVAIKGDSKAIVGSTTGILTIWDRSRGWGDCVDRIPGHPDSVDAMVALTPDIVATGSEDGMIRVIQVLPHKFLGVIATHDDYPIERMELDRRKKWLGSVSHDECIKLTDVEDLFEDSEEEGEGQEDEPAEADEDNDGDRKKKKKNGKAGMGDLNAAKRDKDDTFFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAA3</accession>
    <name>A0A1Y1UAA3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_633486</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869197.1">
        <property type="nucleotide sequence ID" value="XM_022016627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAA3"/>
    <dbReference type="FunCoup" id="A0A1Y1UAA3">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAA3"/>
    <dbReference type="GeneID" id="33558436"/>
    <dbReference type="InParanoid" id="A0A1Y1UAA3"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="18">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="409"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="672" mass="71601" checksum="DF98E73A964AC6EC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB97</accession>
    <name>A0A1Y1UB97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_653133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868618.1">
        <property type="nucleotide sequence ID" value="XM_022018614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB97"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB97"/>
    <dbReference type="GeneID" id="33560423"/>
    <dbReference type="InParanoid" id="A0A1Y1UB97"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="837" mass="90734" checksum="914C41FF360A181F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBN4</accession>
    <name>A0A1Y1UBN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catenin-beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_633107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869112.1">
        <property type="nucleotide sequence ID" value="XM_022016592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBN4"/>
    <dbReference type="FunCoup" id="A0A1Y1UBN4">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBN4"/>
    <dbReference type="GeneID" id="33558401"/>
    <dbReference type="InParanoid" id="A0A1Y1UBN4"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="8">
        <location>
            <begin position="93"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="653" mass="72405" checksum="A63F6FDF65ECD1D6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBN6</accession>
    <name>A0A1Y1UBN6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_100562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869648.1">
        <property type="nucleotide sequence ID" value="XM_022011908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBN6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBN6"/>
    <dbReference type="GeneID" id="33553716"/>
    <dbReference type="InParanoid" id="A0A1Y1UBN6"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13215" checksum="E36200AD16CB54F2" modified="2017-08-30" version="1">MRLTIIAPDSLYEHDVDPSMEVQDIQALIEAETGLASPNFILSTDNGVTMNEVKRSLGSYDLKGENGTIFLTFRDLPSAPSGPSGSSSSSTPGFPTNDAELERMRLQALGDPNLMRELRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBZ8</accession>
    <name>A0A1Y1UBZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_630695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869732.1">
        <property type="nucleotide sequence ID" value="XM_022016352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBZ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBZ8"/>
    <dbReference type="GeneID" id="33558161"/>
    <dbReference type="InParanoid" id="A0A1Y1UBZ8"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011831156" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="480" mass="53412" checksum="1EA5E6C2230E0748" modified="2017-08-30" version="1">MKLSLTALFGLYTGLVAAAVASPQNPFDPPISSTGHALLTSSRHPKHNVHIKAHSAGSWCDPEVRSWTGYIDSGYGKELFFYYFESRSSPKDDPVVMWINGGPGGSSAMGLFLEQGPCRINKDPSGLNDTVVNPYAWNEKANVFFLDQPIGVGFSHGDYGQTVATTEQAAIDVAAFVEIFFEYFDLHGRPFHMSGESYGGRYLPLFASAVFDNNAKLKKDGIEPINLQSVLIGNGLTSIFTTIDTQYELMCTKHIDLGYAVMPIKACVELVEQLPKCHQMLKKHCLETVDHAICTLWEAHCGDLWNLTPLSVERNRYNLNQTCTLEQLEADRCIDGQLDLEKYLNLPDVQAFLGATGHFGLNSHLVNQDFYRALDEVHQTYWYVAGLLERGIRVLNYVGTLDAACPHLSQEKWMAQMPWTGQAGYLDAEWESWQVNGKEAGIFKTYENLTLLKVFGAGHLVPTDQPENALALLNEWIEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC72</accession>
    <name>A0A1Y1UC72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p115 like vesicle tethering protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_581916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869812.1">
        <property type="nucleotide sequence ID" value="XM_022013531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC72"/>
    <dbReference type="FunCoup" id="A0A1Y1UC72">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC72"/>
    <dbReference type="GeneID" id="33555339"/>
    <dbReference type="InParanoid" id="A0A1Y1UC72"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="372"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="837"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="790"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="960" mass="104838" checksum="B9B58D5422B9A021" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC95</accession>
    <name>A0A1Y1UC95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="21">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD324DRAFT_631054</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869825.1">
        <property type="nucleotide sequence ID" value="XM_022016399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC95"/>
    <dbReference type="FunCoup" id="A0A1Y1UC95">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UC95"/>
    <dbReference type="GeneID" id="33558208"/>
    <dbReference type="InParanoid" id="A0A1Y1UC95"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ORX35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1268" mass="137333" checksum="7863C8275E4D8D02" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCG4</accession>
    <name>A0A1Y1UCG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_634869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022016768.1"/>
    </dbReference>
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        <property type="interactions" value="261"/>
    </dbReference>
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    <dbReference type="GeneID" id="33558577"/>
    <dbReference type="InParanoid" id="A0A1Y1UCG4"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
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        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="308" mass="34427" checksum="6BEBE27BFFA2AB04" modified="2017-08-30" version="1">MIGFAKLAKPSNSLQQVYYRRSTSISPSHRSMITLTIVRHGESTDNLKPLWAGWSDAPLSVHGMNQAKALGESFKSTRVDAIYASDLLRALWTAQQIERNQAQRPPFTTSSLLREQNFGIAEHKPFGKEYTRGPGRSFKFEDGESLNDVRARANEAFSQFIERHLQECRRRPPTTRHIVVVAHGIFNAEFIGGLLARRGAQGLDWGYKGMTNTGWTRLELGYEDEMTNPHDADLKTNPDPAVTPSSRPAEPPEVDENQVQLPRLNVRIISTDVTKHLDGIHRQKGGIGSQGFDSSQKDLRAFFSGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCJ0</accession>
    <name>A0A1Y1UCJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_631569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869927.1">
        <property type="nucleotide sequence ID" value="XM_022016448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCJ0"/>
    <dbReference type="FunCoup" id="A0A1Y1UCJ0">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCJ0"/>
    <dbReference type="GeneID" id="33558257"/>
    <dbReference type="InParanoid" id="A0A1Y1UCJ0"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="8">
        <location>
            <begin position="86"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="387" mass="42408" checksum="103D1C796216383A" modified="2017-08-30" version="1">MQPFTKAERVLSIQSHVVSGFAGNKAATFPLQYLGFQVDAVNTVNFSNHTGYGHTNGHKTTAEQLNLIFSGLNDNGLLVPYPRILTGYVPGAEALQCVADQLAEVRRCNPGCVYLLDPVMGDIGRGLYVAEQVIPIYKSMLPLATIITPNHFELELLSDMKITSPSSLQQAIRHLHEKYSLTHVVVSSISLPSSLVSRFDLPGPPDSYQSLLGATTPSRYTGAQDFSTSEGTNLVCLASTYRAEGRQLVTSAYALPNVEAYFAGVGDLFSSMVMAHFGNLSGASEQDLQTAVSKALLIVQRILLRSHMHSMQVDGDASPGENVMPSDTEADNENPRRQGNPSRRARRMRLRELRIIEDRSLLRVASDDGWNGGRVNLELPELDTYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCZ7</accession>
    <name>A0A1Y1UCZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_633323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869161.1">
        <property type="nucleotide sequence ID" value="XM_022016617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCZ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCZ7"/>
    <dbReference type="GeneID" id="33558426"/>
    <dbReference type="InParanoid" id="A0A1Y1UCZ7"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="572"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="652"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="747" mass="82151" checksum="C2A03E2974263CCD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDD4</accession>
    <name>A0A1Y1UDD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycopeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_59025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869698.1">
        <property type="nucleotide sequence ID" value="XM_022013787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDD4"/>
    <dbReference type="GeneID" id="33555595"/>
    <dbReference type="InParanoid" id="A0A1Y1UDD4"/>
    <dbReference type="OrthoDB" id="3342934at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012733999" description="Glycopeptide" evidence="1">
        <location>
            <begin position="20"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18492" checksum="7A13D0968AEE9A9E" modified="2017-08-30" version="1">MWSIVISSILLGAFLATRASPTPRTSESHTVQLVNNCGKGTATFRLEGSGPYTGDTNIIQGPALGGIAWVSDAYGCEDYGQNCGVVEFSLQNPTSQNDQASNAAAYDVQESEVQMHEYKYEMDFALDGCQVSPYVPGPCSGNTPSDCPGAFPADEPVATPFECTADNVGIVITFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDE3</accession>
    <name>A0A1Y1UDE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_630025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870189.1">
        <property type="nucleotide sequence ID" value="XM_022016282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDE3"/>
    <dbReference type="GeneID" id="33558091"/>
    <dbReference type="InParanoid" id="A0A1Y1UDE3"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="723" mass="80678" checksum="8FCDB777EE339CB5" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDE8</accession>
    <name>A0A1Y1UDE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_592204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870182.1">
        <property type="nucleotide sequence ID" value="XM_022013811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDE8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDE8"/>
    <dbReference type="GeneID" id="33555619"/>
    <dbReference type="InParanoid" id="A0A1Y1UDE8"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11332">
        <property type="entry name" value="AmyAc_OligoGlu_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="563" mass="63327" checksum="C6EC2595AD20F45E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDK3</accession>
    <name>A0A1Y1UDK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand calcium-binding protein, Caltractin-cdc31 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_634066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869371.1">
        <property type="nucleotide sequence ID" value="XM_022016699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDK3"/>
    <dbReference type="FunCoup" id="A0A1Y1UDK3">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDK3"/>
    <dbReference type="GeneID" id="33558508"/>
    <dbReference type="InParanoid" id="A0A1Y1UDK3"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="174" mass="19899" checksum="F5A50EC3247CE6FF" modified="2017-08-30" version="1">MFPKTKQRRPITGSSNLHHTPSPSSRQPSLTEDQRQEIKEAFELFDSDKDGAVDYHELKVAMRALGFDLKKVEVVDLLKRYGGDDGLMDFEAFQRIMTERILSRDPMTDLKRAFALFDDDRTGRISLKNLKRVAKELGESLGDEELSAMIEEFDLDGDGEISEQEFYAIMMDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE38</accession>
    <name>A0A1Y1UE38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_651551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870412.1">
        <property type="nucleotide sequence ID" value="XM_022018351.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE38"/>
    <dbReference type="GeneID" id="33560160"/>
    <dbReference type="InParanoid" id="A0A1Y1UE38"/>
    <dbReference type="OrthoDB" id="2595639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="435"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="599"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1343" mass="148194" checksum="35739BE08325EF5C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE66</accession>
    <name>A0A1Y1UE66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_651552</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870413.1">
        <property type="nucleotide sequence ID" value="XM_022018352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE66"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE66"/>
    <dbReference type="GeneID" id="33560161"/>
    <dbReference type="InParanoid" id="A0A1Y1UE66"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="16">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="15">
        <location>
            <begin position="732"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="14">
        <location>
            <begin position="835"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX36312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="928" mass="102751" checksum="F2B7240689DE0B04" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEF8</accession>
    <name>A0A1Y1UEF8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_628814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870534.1">
        <property type="nucleotide sequence ID" value="XM_022016147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEF8"/>
    <dbReference type="FunCoup" id="A0A1Y1UEF8">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEF8"/>
    <dbReference type="GeneID" id="33557956"/>
    <dbReference type="InParanoid" id="A0A1Y1UEF8"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="218" mass="24174" checksum="D2E859CAC70CD90E" modified="2017-08-30" version="1">MTEQGYLSSGSGSGKMSGGEGSDRSSIVLKVGMVGDSQIGKTSLMVKYVEGSFDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVSMLPLVSNDAVAILFMFDLTRKATLNSVKEWYRQARGFNKTAIPVLVGTKYDMFVSFPHEEQEEITKQSKRFSKAMHAPLVSRSMFAASDQQIFCSTAQAINVQKIFKIVLAKAFDLKVGRVPVDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEH8</accession>
    <name>A0A1Y1UEH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ER membrane protein SH3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_498138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870554.1">
        <property type="nucleotide sequence ID" value="XM_022012948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEH8"/>
    <dbReference type="GeneID" id="33554756"/>
    <dbReference type="InParanoid" id="A0A1Y1UEH8"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="219" mass="23843" checksum="8F87D47E68E0CE5F" modified="2017-08-30" version="1">MVWRTTAITLSTCFLLGTTFTHWIADHNVLWRSPLTSEALSQSISYYALLANAPKGLEWVYFAAGAIALICAGGRMVKDWRGRHGEVLFDGGSLVLLGAIAYNQLTELAPTLALFPLSVPTDLPKHSLWPVLVTAVRDLANDNVITAVMLTGVMLLQAGRYHAKKKSPIPSTPTSSQSPAVSRTGSPLLDRKSTPYRELTEQEAFELRADTSDDDSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEL5</accession>
    <name>A0A1Y1UEL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_628909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870563.1">
        <property type="nucleotide sequence ID" value="XM_022016155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEL5"/>
    <dbReference type="FunCoup" id="A0A1Y1UEL5">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEL5"/>
    <dbReference type="GeneID" id="33557964"/>
    <dbReference type="InParanoid" id="A0A1Y1UEL5"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="135" mass="15037" checksum="36DAF6E99C471551" modified="2017-08-30" version="1">MADAQVGALQAKLQTSTIAFQKIEQELSTVIEARQRLDSQLSENEQVLKEFASLKSHNTVYKLVGPSLMPQDSAEAKQNVEKRLDYIRNEISRVEAQLKEVQDRATKKKEEIIALQQQFQSLQGPSAAAGRPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF61</accession>
    <name>A0A1Y1UF61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870752.1">
        <property type="nucleotide sequence ID" value="XM_022018286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF61"/>
    <dbReference type="GeneID" id="33560095"/>
    <dbReference type="InParanoid" id="A0A1Y1UF61"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="318" mass="34255" checksum="5DCA9FDF05818853" modified="2017-08-30" version="1">MFNMPTLTETNRGVEPTTPSQQPGPHTRRETLPSKHESISSDTQSHHLLPFSPLSPTSTAFAYGYYHLGTPADIATQSPGINSALTTAHTPSVDPSVVAVQGSVVTSDNKGQMFKDLAAGKRATLEPKRQGTVEHGWKNDKGDMAQEIDEDVVAPALPARGSILIDYDALVQVPGATTNLCATLFAWKGFGYSIHIWTKDKEATSFLLEDDQVVSVTQSKSVVDRVWELPTRGGQESPPVDPLQQIVADSTAILILNTTSAFDRVSQTLTQGVNVLLLKDLSPMGEEISRSIHPDQAAVVAGWKECTEWLLNSNGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFH8</accession>
    <name>A0A1Y1UFH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_627300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870889.1">
        <property type="nucleotide sequence ID" value="XM_022015984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFH8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFH8"/>
    <dbReference type="GeneID" id="33557793"/>
    <dbReference type="InParanoid" id="A0A1Y1UFH8"/>
    <dbReference type="OrthoDB" id="2561686at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="94" mass="10437" checksum="0BC822B4D9033F80" modified="2017-08-30" version="1">MANLFEGIFHLIQGFFQSIFAIIQSIFHVIWSIFSGVFQAVWGILESIADLVGASAHFVASNILVLGLIALIYVLYRDRNRPGSAGNELKKKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFL8</accession>
    <name>A0A1Y1UFL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_651272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870858.1">
        <property type="nucleotide sequence ID" value="XM_022018304.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFL8"/>
    <dbReference type="GeneID" id="33560113"/>
    <dbReference type="InParanoid" id="A0A1Y1UFL8"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="1349"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1635"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1699"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1791"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="952"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1707"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1724"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1825"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1903"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1915"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1944"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1974"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1999"/>
            <end position="2012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2062" mass="217661" checksum="98D6F4198C8FED58" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFP3</accession>
    <name>A0A1Y1UFP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">BD324DRAFT_591949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFP3"/>
    <dbReference type="FunCoup" id="A0A1Y1UFP3">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFP3"/>
    <dbReference type="InParanoid" id="A0A1Y1UFP3"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="310"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="406" mass="44509" checksum="BD7F350BBDA6A31C" modified="2017-08-30" version="1">MPLLELVQELPGHSEPAWQVAFNPSRPLLASCSTDKTVRLYSFDDRSFSDSLPASDDPKPTFSLLSAIETEHKRTIRSVAWGPDGRTLATGSFDSSVGIWEEVDSDAPEDDSEGVFKPSTEIGGEKVVSGAGEWECVTTLEGHESECKSVAFSSDGALLASCSRDKSVWVWEVQPDADFECIAVMMEHTQDVKCLAWHPKEEVLASASYDSHIHLMFDDPDGDWCIFQKLHPKLPSARTQSSLPELSPTADEKAIESLNIPPLEEDETVWCLAWSPCGRYLASGGDRGGIRIWRRKGNQPDSLFEEILHTAAHSRSVFSLSWRKGGYLASAGGDGKIIVWKTDVIEDGDGPVAPRLSMNPVAAVREAHSVDDVNSLSWCSREEGRGFLLASCGDDGGVKVWRLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG01</accession>
    <name>A0A1Y1UG01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60S ribosomal protein l9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_627794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871011.1">
        <property type="nucleotide sequence ID" value="XM_022016040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG01"/>
    <dbReference type="FunCoup" id="A0A1Y1UG01">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UG01"/>
    <dbReference type="GeneID" id="33557849"/>
    <dbReference type="InParanoid" id="A0A1Y1UG01"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="192" mass="21279" checksum="EBB55C231C4362E7" modified="2017-08-30" version="1">MKDITSVETLTIPEGVTVTIKARKVTVEGPRGTLTKDVGHVAMDIQIVPRAGKKVIVFTVWHGARKHVACLRTIKSLVENMITGVTKGFLYKMKLVYAHFPINAIPENDGAALQIRNFLGEKYIRNVPMLEGVKISTSDVKDELILQGNDVQNVSQSASSITDVCRVKNKDIRKFLDGVYTTERTTVVQEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGK1</accession>
    <name>A0A1Y1UGK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_428915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871190.1">
        <property type="nucleotide sequence ID" value="XM_022012763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGK1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGK1"/>
    <dbReference type="GeneID" id="33554571"/>
    <dbReference type="InParanoid" id="A0A1Y1UGK1"/>
    <dbReference type="OrthoDB" id="2596104at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="212"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="324" mass="35806" checksum="46EC3D75EAC6A512" modified="2017-08-30" version="1">MSEVGEPGSSYTVLRIKRKATEPPLSSLVIQSAIIDPRRKRRKDELVKSRGIFRLADTVPDTWQGQGSEGDVLRRRIKGLLESRQTNTSPQSPHPPQPLTPQTRPVGEPSKPRQVPNVPRTQYRIVPRAAQQEAGMPPRVLSNAELNAAALKLVDAEAVASSSQSNKAASEPNTSNPDEEEEMAAFLPMLQEYLKLEGKSALDNPPSEPEAEQYVYDLYYRDIRSSQSSTPLNLGQGDGVHIGALLGYQDDDGDSDVSDSEPEDEADEDSNDEDYYRNDYPEDEDGDEDMHGYKDAFGEDEDEESASDPESEGGRGHGGLWSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGM3</accession>
    <name>A0A1Y1UGM3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_626758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870746.1">
        <property type="nucleotide sequence ID" value="XM_022015928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGM3"/>
    <dbReference type="GeneID" id="33557737"/>
    <dbReference type="InParanoid" id="A0A1Y1UGM3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="264" mass="30208" checksum="7E629817A7FC1BF3" modified="2017-08-30" version="1">MSHHRYQSTGSYTPVLIRPSRSSDAALLRPPGPPPRLKYPYPIPIISLLDLSYTIHASRNRRVASHFLPLAIGRTLILLLAIGSSTRWRVRGGWVAVCSAVTVLGTVWEVCKDRLDPAASDGVEASDTAFLIMTATMAILQYVRRFIDDIQVPQTLIDHSYSSFLSFFYASRHLHTVSILSHFDCLDLLFRRRPLSNTRPTLTMARLEERHRDLETRMTRKRSWRTMNPYHLRGVITLVSRVKRLLGQFLRVFPLIPKAMMEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGQ3</accession>
    <name>A0A1Y1UGQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_482718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870346.1">
        <property type="nucleotide sequence ID" value="XM_022012907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGQ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGQ3"/>
    <dbReference type="GeneID" id="33554715"/>
    <dbReference type="InParanoid" id="A0A1Y1UGQ3"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="590" mass="65162" checksum="27D150F15FB1DBAC" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGR3</accession>
    <name>A0A1Y1UGR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_642167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871288.1">
        <property type="nucleotide sequence ID" value="XM_022017469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGR3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGR3"/>
    <dbReference type="GeneID" id="33559278"/>
    <dbReference type="InParanoid" id="A0A1Y1UGR3"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="459"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="566" mass="62929" checksum="CE1B7D6B34005A81" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGZ9</accession>
    <name>A0A1Y1UGZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_642187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871340.1">
        <property type="nucleotide sequence ID" value="XM_022017471.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UGZ9">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGZ9"/>
    <dbReference type="GeneID" id="33559280"/>
    <dbReference type="InParanoid" id="A0A1Y1UGZ9"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1438"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1156"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1086"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1791" mass="191598" checksum="6257B231737F922A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH40</accession>
    <name>A0A1Y1UH40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein LST8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_579330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871406.1">
        <property type="nucleotide sequence ID" value="XM_022013375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH40"/>
    <dbReference type="FunCoup" id="A0A1Y1UH40">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH40"/>
    <dbReference type="GeneID" id="33555183"/>
    <dbReference type="InParanoid" id="A0A1Y1UH40"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032535">
        <property type="term" value="P:regulation of cellular component size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000505">
        <property type="entry name" value="Blast:Protein LST8 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="339" mass="37136" checksum="B7AD52C536C10F35" modified="2017-08-30" version="1">MPTATQPQPSQAQNQHVDPAQAHAQAQAAEMSVILCTAGYDHSIRFWEAWSGICYRQITLQPQWKQVNRLAISPDKIFLAAAGNAMVRIWDIPSLSNTPVASLEGHTANVTALAYSSQGKWIVSGSEDCTVKVWDTRTSQVQRNYDHDAPVNDVVIHPNQGELISCDQLGTVKIWDLGENTCTHELVPEEDVAIRSVSIASDGGTLVAGNDLGTVYVWQIESTVDSTTLRPGTSFQAHSKYITRCLLSPDTRHLATCSADGTIKIWSTANFEYTLVKTLTGHQRWVWDAAFSADSAYLVTASSDHAARLWDLTSGETVRQYDGHHRAAVCCALNDINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH98</accession>
    <name>A0A1Y1UH98_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871466.1">
        <property type="nucleotide sequence ID" value="XM_022018249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH98"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH98"/>
    <dbReference type="GeneID" id="33560058"/>
    <dbReference type="InParanoid" id="A0A1Y1UH98"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22771">
        <property type="entry name" value="OTU_plant_OTU7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="143"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="424"/>
            <end position="504"/>
        </location>
    </feature>
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        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="504" mass="54185" checksum="440D7A858CC96612" modified="2017-08-30" version="1">MDIQSPPEAEAGPSRLRRSQPSTRPLIVSDYHSYHHPYIGPLIGGGNHKRNTHHAKRNARPKQHLQLTPSGDPTPALGSGTASSSSRRSAGTKTSKGGGGTNGRKRVTRAQARARGSSSPMTDLEAIALEDAAVKGEISRLGLGLRDVQGDGNCLFRALADQLWGVARRHGEVRKLVCDYLETNKDGMEAFVWPFLKEGEDYQGYVERMRQLSQFGSHIEIQAAARVFRRNIRVVMSTTSFTIPWQTETESHQTPRPDQSMEEDYFTIPRPRTRSSTTNLLMTPALPPPSTPSYAKTLAEYIPSIRPGRSMLWLALFSQAEHFQSIRRKGDGDSGPAEIEDRLAIPHEKDQSEAARRQRGEVVEGPSQGSSSIASGGSSVVSQVLASLPAGHGVSEDRASGILARVKGDLGEAVELLLEELRLEGSDPEQHGQGTTSSSDGGSSPTTASSSNPTSPSEQADDQVKPPLQNVSSGGRGPIRGTSHRGNGGARGRVRGRPVAVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHL9</accession>
    <name>A0A1Y1UHL9_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_608135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871540.1">
        <property type="nucleotide sequence ID" value="XM_022014104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHL9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHL9"/>
    <dbReference type="GeneID" id="33555912"/>
    <dbReference type="InParanoid" id="A0A1Y1UHL9"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
            <begin position="524"/>
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        </location>
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            <begin position="633"/>
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        </location>
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        <location>
            <begin position="649"/>
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        </location>
    </feature>
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        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="690" mass="73890" checksum="F2A8697D50A2CB13" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHQ8</accession>
    <name>A0A1Y1UHQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_624655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022015723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHQ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHQ8"/>
    <dbReference type="GeneID" id="33557532"/>
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    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="193"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
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            <begin position="350"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="425"/>
            <end position="452"/>
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    </feature>
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            <end position="794"/>
        </location>
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            <begin position="1"/>
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            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
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        </location>
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            <begin position="139"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="389"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="794"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="928"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="944"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1036" mass="111405" checksum="C17D2B3738268A1D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHV3</accession>
    <name>A0A1Y1UHV3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871630.1">
        <property type="nucleotide sequence ID" value="XM_022018116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHV3"/>
    <dbReference type="GeneID" id="33559925"/>
    <dbReference type="InParanoid" id="A0A1Y1UHV3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="234" mass="25768" checksum="894FBB2474EAAC8D" modified="2017-08-30" version="1">MSTAQSDRAATNTDARKILHGHEDRDGRRLCLKAGFPYDESGENYSAKGHIHAGLWVKPLKDDIFERSSTNSGQEFWEELTGAELELQPAGESETWDLKIKDSPSGPEMYTGKALCSNKGFRYTYDFFSSLYNHDQGVEDAGESDEEDSQGSLLEIAHKLASENKKSTEANNTFANEDGLALSQATAIYKLHVDPRTLTEASVPDPDLRAKLSNLTWTAEGSAQVSMRGSLVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UI61</accession>
    <name>A0A1Y1UI61_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCA2, oligonucleotide/oligosaccharide-binding, domain 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_623093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871725.1">
        <property type="nucleotide sequence ID" value="XM_022015548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UI61"/>
    <dbReference type="STRING" id="4999.A0A1Y1UI61"/>
    <dbReference type="GeneID" id="33557357"/>
    <dbReference type="InParanoid" id="A0A1Y1UI61"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="2">
        <location>
            <begin position="433"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="801" mass="88004" checksum="D23DBD63F3873C11" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UII7</accession>
    <name>A0A1Y1UII7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_680689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871796.1">
        <property type="nucleotide sequence ID" value="XM_022019089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UII7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UII7"/>
    <dbReference type="GeneID" id="33560898"/>
    <dbReference type="InParanoid" id="A0A1Y1UII7"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013299387" description="Galactose oxidase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="85326" checksum="1D5E9032866E3286" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIN7</accession>
    <name>A0A1Y1UIN7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_623588</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871849.1">
        <property type="nucleotide sequence ID" value="XM_022015601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIN7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIN7"/>
    <dbReference type="GeneID" id="33557410"/>
    <dbReference type="InParanoid" id="A0A1Y1UIN7"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX37862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="262" mass="28382" checksum="7D667B579A78B820" modified="2017-08-30" version="1">MAPQPPHPLRRISTGSLSTLARSQDRSAASPSGLDFLGPAMMELADEAATLAANIEHLNEMHDALGTFNESFAAWMYALKMNAFCVEWPQAPSESTYSRLPQLEEAMAAVQKRAQKKDGPTESSRKATATPIADMTYKTETGSPSPPPRKSLAPKKSVAAGPSAAAKKAAVDKKKRRMVEISGYIDMLPLEYRGAQPAQRQHMETIINKLMDKPAGAAMKDLLDPPQLPQAKVNKCLIALVGKKLVVKENVGGATWYKWVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIP6</accession>
    <name>A0A1Y1UIP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_408679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871920.1">
        <property type="nucleotide sequence ID" value="XM_022012703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIP6"/>
    <dbReference type="GeneID" id="33554511"/>
    <dbReference type="InParanoid" id="A0A1Y1UIP6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="249" mass="28948" checksum="6878747D37C18599" modified="2017-08-30" version="1">MPLFAHLETFHLTVKHYEETILGPRGKNLPVGSIFWPVIEGIFSLCSARHVRFIQMMALKPQPCKFCGFRCQCPTAHFRHGYDRGMGDWTPEGSRIEKILSRWPLETYDLPFLPKQLPIQGMRMTASGQFGRVHPVSFLFNGDETTKEHDFDEYLAKFVQHMKEKKAHSRRWRRRFERTGPKWYCSGMTVAQQVYFGDHWVDAVYRLTLPKGMSREQLCGAFEAHIVGGYAPFQLDSGKAWRQWTSTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIY7</accession>
    <name>A0A1Y1UIY7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_417001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872007.1">
        <property type="nucleotide sequence ID" value="XM_022012723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIY7"/>
    <dbReference type="GeneID" id="33554531"/>
    <dbReference type="InParanoid" id="A0A1Y1UIY7"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="538" mass="60074" checksum="1FE657E761FF8EB1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ03</accession>
    <name>A0A1Y1UJ03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_424910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871123.1">
        <property type="nucleotide sequence ID" value="XM_022012742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ03"/>
    <dbReference type="GeneID" id="33554550"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ03"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="882"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="813"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="975" mass="108215" checksum="1C9866CCBEA6DD5D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJV0</accession>
    <name>A0A1Y1UJV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA-processing protein 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_620457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872253.1">
        <property type="nucleotide sequence ID" value="XM_022015285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJV0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJV0"/>
    <dbReference type="GeneID" id="33557093"/>
    <dbReference type="InParanoid" id="A0A1Y1UJV0"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="413" mass="44959" checksum="28E1E9D26681083E" modified="2017-08-30" version="1">MPKAVVPVNKGKGKSTVQHSKLYTNFLPIELLLPAPSTSSSSQSRVTSHYIYVRPHTAKSGSTSSVTASPESTVFVANIPVDASERDLRVLFGRWGVVEFVEFTGGSGANALEQAVQGLGEDDEVEQEEEEGEEESDDEAQDPINDLRDTEEDNVTSRPEPTFIGNGPKLPRRLRTRRKPALPVSVPEVEALPPLDPRSTPYGRSGSRCAHIVYLDALPLQRLMAHTGPIHLPSYGLLPQSAYSKPAKSSLKSMASPQSDPSNPTGLSYYISQYTSLRPPLGAIKAFADSSMARFDHLQSLLLKSRAKQQGAGALVDEDGFTVVVRGGRYGRTGGRGPGSTGVAVASKGFGKNLASEQDDGKRKGSGARPKEDFYRFQKTERKRQELAGLRAKFEQDKAKVDELKKTKRFTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK01</accession>
    <name>A0A1Y1UK01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_623561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871844.1">
        <property type="nucleotide sequence ID" value="XM_022015598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK01"/>
    <dbReference type="FunCoup" id="A0A1Y1UK01">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UK01"/>
    <dbReference type="GeneID" id="33557407"/>
    <dbReference type="InParanoid" id="A0A1Y1UK01"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="99"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="591" mass="63245" checksum="D099BDDC711BA14E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK31</accession>
    <name>A0A1Y1UK31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_649780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872333.1">
        <property type="nucleotide sequence ID" value="XM_022018046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK31"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK31"/>
    <dbReference type="GeneID" id="33559855"/>
    <dbReference type="InParanoid" id="A0A1Y1UK31"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="479" mass="52217" checksum="96DDD4F595EB1514" modified="2017-08-30" version="1">MPRFPASQLKTPVVPSLRAASTLARPTSQTAIQLASKSPIRAIVILPIQLNGTASPTHVQLAQRRWASSSSEKEAAAKQLANTSRPTDESGSTASNEGIVQGATRELKSVASGVAEIISGGGHHSSRQEKTDSGAGPHGAQEISSHSHSGSVRDDFIGITKNIFQWVPQPALVVGLAGTLPYLGTAFGTIFLAREAARESQGLSTITGGSLDSILGNLHTLEHIQITYGAIILSFLGAIHWGMEFSKYGGYQGYNRLALGVAPVLIAWPTTFLPHGLALVAQWLGFTGTWFLDQRASSNGWTPPWYATYRFYLSLIVGFSIIATFAGTGYYGAGAGATVTSKDKRTLHTTERVSPLKKMSRIEEAKHPKHGETLTGRATGTVKGPIALEEEEDGDHFLKLRNFKKEKEEEEEREREEEEERQKKEEEKKTKKEENQKFQDERDQHQQEKAPGSMKSEAKNRTGENELADGKDKTEANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK69</accession>
    <name>A0A1Y1UK69_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_620899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872370.1">
        <property type="nucleotide sequence ID" value="XM_022015336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK69"/>
    <dbReference type="GeneID" id="33557145"/>
    <dbReference type="InParanoid" id="A0A1Y1UK69"/>
    <dbReference type="OrthoDB" id="2552152at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="31033" checksum="CFED780DB6BA349D" modified="2017-08-30" version="1">MSERVRARKEARERERRAKGLPEPESSEQSDRGRDTATLSPRAASGSSALPRNDSLSLFGGPSDQSSSFAYNLPSLPFNIPVSPESSFPDFSSHMESNLFKGSSGPSASSFNNMFSMFASPTDTSDQRPPPTAHHTGLDHRSPPTPPLSAPGSGGSPGQPDLLTRLKSCCHLSDSHVVNDPGLLIFATRLCQSFPCAFNGAHPDSAYGSDNEHLLLEDSWKALKMQLDPGGEADGENRINTGRMAAELVCRAAATRGSGGGWIICRYREGLSIKRHLIAGLVQGLGGSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKJ2</accession>
    <name>A0A1Y1UKJ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_622712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871632.1">
        <property type="nucleotide sequence ID" value="XM_022015507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKJ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKJ2"/>
    <dbReference type="GeneID" id="33557316"/>
    <dbReference type="InParanoid" id="A0A1Y1UKJ2"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012869709" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="221" mass="22099" checksum="27EC61F25AF97554" modified="2017-08-30" version="1">MYSSSQAVISAIILAALANGISVNSPNAYSEWQSGTSSQTVTWTAVSTDPSSFLIQLVNQQGFLPNGPVTLSSSTNTGSPNQQNSATVSYPSGSWPEGHGFQINLMSSDQNNAAILAQSNQFNITSGGSSSNSNSVSVANAVPSSSSGVPPITLTNGAAVQTTGTSQSTLTSLPAGYTGDATGGIPNAVTSTKGAAPSQFGKPGPFIGFLIAAAGVFGVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKM8</accession>
    <name>A0A1Y1UKM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_368924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872520.1">
        <property type="nucleotide sequence ID" value="XM_022012600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKM8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKM8"/>
    <dbReference type="GeneID" id="33554408"/>
    <dbReference type="InParanoid" id="A0A1Y1UKM8"/>
    <dbReference type="OrthoDB" id="2564742at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="557" mass="61159" checksum="5D59D8FB13E9F9F2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKR3</accession>
    <name>A0A1Y1UKR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871712.1">
        <property type="nucleotide sequence ID" value="XM_022015540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKR3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKR3"/>
    <dbReference type="GeneID" id="33557349"/>
    <dbReference type="InParanoid" id="A0A1Y1UKR3"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="329" mass="36092" checksum="FD66ED40D60C0AB9" modified="2017-08-30" version="1">MSGSQSKQDVPKAILYTWPASVWSNVPLLCLHEKGYGEDEYIVKHVDLSKGENFSPSYLKINKNGTVPTLVVPTAETTSADVDSRYRSLRDTITICDFLDQARSANTVNTTSSRPAPTLSPATIEGKAIVDEIIALVHLPSVDPNFLAMSARDETELKQKAESASGAMVRDRRASLDKYIKEAKEGASHGGSFETSIVKFLEERFAANEMIYKVYTGGSNPEDLKMFYEASAKIWNTGIPDCLDRLEGLIQDDGPFTMGDQVSLADLHVISWLSRVVALAANSKPALEIDALEKVLGGRKIGNKVRGFWTAWLSRESFKKTIGQNSALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKX7</accession>
    <name>A0A1Y1UKX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_619928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872119.1">
        <property type="nucleotide sequence ID" value="XM_022015231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKX7"/>
    <dbReference type="FunCoup" id="A0A1Y1UKX7">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKX7"/>
    <dbReference type="GeneID" id="33557039"/>
    <dbReference type="InParanoid" id="A0A1Y1UKX7"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17628" checksum="2AB67142D2ACBBDA" modified="2017-08-30" version="1">MPAYRPLTSQSAAGPSVARDRQADALAEFRARRLQRKLEDLERTNPTDIPASSFAVNPPPSSASTLTTSLNPAVQSKKKQSGNVRKILYARKSLKDWLEELPPEPKPPYLLAVAPPPSMPPRGSCSSCGYVGAYKCPRCGEWSCDRNCMGIHERDGGCGVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKZ8</accession>
    <name>A0A1Y1UKZ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_622125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872652.1">
        <property type="nucleotide sequence ID" value="XM_022015439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKZ8"/>
    <dbReference type="GeneID" id="33557248"/>
    <dbReference type="InParanoid" id="A0A1Y1UKZ8"/>
    <dbReference type="OrthoDB" id="2563848at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="153" mass="16382" checksum="F81299385B1F1E60" modified="2017-08-30" version="1">MTTEQQREARSSAPSDSAHPSSALQLGSLLPQANTSHHSLLDAVIGPSQQKKQPPQLPQAADDPQTRSRNTSGSQDATSFGTSTEKSWDVLSDASVRVNRDTSNGGAVEELQKQVDKRKSQLPALEIELAALEAKIKEAEERLARAKAQAQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL29</accession>
    <name>A0A1Y1UL29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_621954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872614.1">
        <property type="nucleotide sequence ID" value="XM_022015428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL29"/>
    <dbReference type="STRING" id="4999.A0A1Y1UL29"/>
    <dbReference type="GeneID" id="33557237"/>
    <dbReference type="InParanoid" id="A0A1Y1UL29"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="218"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112935" checksum="D8E0F846864C06C3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL32</accession>
    <name>A0A1Y1UL32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_649582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872126.1">
        <property type="nucleotide sequence ID" value="XM_022018014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL32"/>
    <dbReference type="FunCoup" id="A0A1Y1UL32">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL32"/>
    <dbReference type="GeneID" id="33559823"/>
    <dbReference type="InParanoid" id="A0A1Y1UL32"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="140"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="604" mass="67181" checksum="EE179EDE8591FF91" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM67</accession>
    <name>A0A1Y1UM67_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dipeptidyl-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_587977</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873003.1">
        <property type="nucleotide sequence ID" value="XM_022013760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM67"/>
    <dbReference type="FunCoup" id="A0A1Y1UM67">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UM67"/>
    <dbReference type="GeneID" id="33555568"/>
    <dbReference type="InParanoid" id="A0A1Y1UM67"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="217"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="688"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX39140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="896" mass="100428" checksum="141030A7AE74076E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMF1</accession>
    <name>A0A1Y1UMF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_649322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873101.1">
        <property type="nucleotide sequence ID" value="XM_022017973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMF1"/>
    <dbReference type="FunCoup" id="A0A1Y1UMF1">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMF1"/>
    <dbReference type="GeneID" id="33559782"/>
    <dbReference type="InParanoid" id="A0A1Y1UMF1"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="440"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="642"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="872"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1060" mass="120271" checksum="DE828140F952D174" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNL8</accession>
    <name>A0A1Y1UNL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_614493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873435.1">
        <property type="nucleotide sequence ID" value="XM_022014600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNL8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UNL8"/>
    <dbReference type="GeneID" id="33556408"/>
    <dbReference type="InParanoid" id="A0A1Y1UNL8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="2">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="446" mass="49555" checksum="E5D6D5F67C1A671B" modified="2017-08-30" version="1">MIPRPFRLRLLGVTHRQLSARPASSWSLSSRKATSSRTSDVAPKITLTAPSTWTDSRSRGFVSATSLGHSTSSGSQVTGTRSMHTFASRSLNHGRRRRRALSLAAAREKQSIASSLSSRPEGSSRFMPLPRRSSPEAPILSSPVQAAKHVKATPSHLPLPIPLGNDIYDLSNVLDPSSVYGSELPPSIFGERGYSIWSDRNDPQALVAARREEAFEDLLAEMQDKSGGAATTLTGHLNILAALDPVDLAPQTRTLQEADADLKEDEFEPSELQSLLRDKQTRYNIESQMEWNKILAHLGDKSVKLPSDALFKSFSPQDLSTLEMDQSLQVKDAISNLFSTLKRIDPGHIRGGGRLRNRVLRFGGRHRPPHPETFVEVSNSDNGETMLVSVMGDEHGRTRYSIIGDEEGDAVYQMTSVVRKRRLKIKKHKYKKRRKAQRALRRRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNU6</accession>
    <name>A0A1Y1UNU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_614554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873457.1">
        <property type="nucleotide sequence ID" value="XM_022014612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNU6"/>
    <dbReference type="GeneID" id="33556420"/>
    <dbReference type="InParanoid" id="A0A1Y1UNU6"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="476" mass="51034" checksum="58EA2CEDAA2588AB" modified="2017-08-30" version="1">MAWLDSIRNAVSPSAEPINAPDEGYEVIRGEEGDELVHSTEALRPIPTTSKGVHVAFWTLGAGILLSWSALICSFPLMSLFFQEGSTRTNLASYLGTLYCFGNFVCLGLARNNHSATSLNNRQWFSLSLLMTACVFALPAICFIPFNFNDPFVPAFQLFIITVSLSVATGILQSTVFALASLWGSNSVLAVMSGQGGVAVLVSGFQLVVSILAAFGPGSRDEGSVGDPSRSATVGVWLLVFAGTLGCMVAHRYLFRHPDCHLVLAPLLAREDGTETQAKGFFGDQTSRSVFQKNIRLEVAVALVFIITLAVFPPVTSTITSVRSPPPMLLQASVFIPLHFFIFNVGDYIGRTYLPVIPRLMITDPSKILWLSMSRVVYLALFAWCNVSPGNGRAPLINSDMAFFAILLSCGLTNGWISSLSMIVASSPALNPRITDAEKDVAGNLAAFSLVGGLLGGSLLSFVVNWAIRGDPFSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPB0</accession>
    <name>A0A1Y1UPB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_575962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873656.1">
        <property type="nucleotide sequence ID" value="XM_022013161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPB0"/>
    <dbReference type="FunCoup" id="A0A1Y1UPB0">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPB0"/>
    <dbReference type="GeneID" id="33554969"/>
    <dbReference type="InParanoid" id="A0A1Y1UPB0"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000002">
        <property type="entry name" value="Trehalose-6-phosphate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="992" mass="110206" checksum="BAAD26B0356EA19A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPE0</accession>
    <name>A0A1Y1UPE0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 6</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_619471</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873247.1">
        <property type="nucleotide sequence ID" value="XM_022015176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPE0"/>
    <dbReference type="FunCoup" id="A0A1Y1UPE0">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPE0"/>
    <dbReference type="GeneID" id="33556984"/>
    <dbReference type="InParanoid" id="A0A1Y1UPE0"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000023">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX39384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="230" mass="25494" checksum="FE5262E63A342AD8" modified="2017-08-30" version="1">MATKVAQKRLQKEYLSMQKSPPPFIWACPEEKNILDWHFIIRGPPDSPYEGGEYHGLIWFPSDYPFKPPDVKLFTPSGRFDPGHKICMSMTSYHPSTWNAAWSVATILTGLLSFMLSDEITAGAAKTTVEQKKALAKQSHAFNLNNKKFREIFPTYATPEMTDLPDMGKAPGSSSTKGVSAPQPTPETPPPPPPPVVVNHAHGRWIPSWRWIVAVVVLAIVGRLSTFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPJ4</accession>
    <name>A0A1Y1UPJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_618365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872918.1">
        <property type="nucleotide sequence ID" value="XM_022015019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPJ4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPJ4"/>
    <dbReference type="GeneID" id="33556827"/>
    <dbReference type="InParanoid" id="A0A1Y1UPJ4"/>
    <dbReference type="OrthoDB" id="2218151at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="451" mass="49724" checksum="0F678E092338AF46" modified="2017-08-30" version="1">MDRLRSLRAKMPSSPSMATLPGGKLTKAFKFNKEAKVLPNSQSRWGANPFNEGPNLEEPSLPRFHLVLHCAAIFFTFLAICMTGAVANFQATWFAVSGGTAFTLFLLLVAILLSVALFIVPTVYDRWDKLKSANGFLSAPRTRLIIHAFGALLMLIAAFIVTVSAWTSKGCKNPEDDPHHDLGDEYTTNLGQWCQTKKASGIFEWLSFISWLVLLILTLVEWRRERRDEPRFVPPESGISNVNVHERLARRRDDEEATIVEDPYAEKEVDDPKTALRSGYESYGYSRTAPEDDLESEAFGRPSMDTHVGNSTLNGTTLGGGGSMSRIGESGEASRTMQIAYHDPCECSIADLKSQAHAAGVDAHIRQSLLGGSSNPYAPVDAQQTPVQAHTYQTVPVQQVQQVPQIQQVQPVQAVQQVHQTYPAQLLSPTQYGRGVLPQPPTYQTGYGGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPV5</accession>
    <name>A0A1Y1UPV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_614317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873392.1">
        <property type="nucleotide sequence ID" value="XM_022014583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPV5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UPV5"/>
    <dbReference type="GeneID" id="33556391"/>
    <dbReference type="InParanoid" id="A0A1Y1UPV5"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06563">
        <property type="entry name" value="GH20_chitobiase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF57">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="6">
        <location>
            <begin position="11"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="396" mass="45076" checksum="64325181C232E26D" modified="2017-08-30" version="1">MSFLPSDDGAFQWRGFMLDACRHFWPMEEVRRLVDGMALLKLNVLHFHLSEDQGWRFESKKWPKLTEIGAWRDETLVGRPAKWEDGNLYPESYKDKFDGKKHGGFYTQDELKELCAYAKKKGITVVPEIDMPGHMRAARAAYPELGYDGKVLKVGKAWGVYPEVLRVDELGLKFCKDILDELCEVFDSPYIHIGGDECPKSEWEESQTAREQLKEIGGKHMDELQRHFTTQIAAYLHEKGKKMLGWDEIIDGGVPGGDPIVVAWRDWTKAAQRSTAAGVQTIQAPGLLYFDHAQGPVDKEPLSIGPGADLEAVYAFDPYKGIEEEHKDLIYGMQAQIWTEYVPTIDHLWYMVFPRLIALADVAYLGDKRPSYEEFRKGLPARLEELKALGIGSHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ41</accession>
    <name>A0A1Y1UQ41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_616231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873877.1">
        <property type="nucleotide sequence ID" value="XM_022014808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ41"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ41">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ41"/>
    <dbReference type="GeneID" id="33556616"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ41"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="470" mass="51809" checksum="848019E9C9CA6897" modified="2017-08-30" version="1">MKLLPTPPADATKFCNFITGSPTPFQAVANLSARLVESGFKPISERLLNSAELANGGKYFYTRNQSSLVAFTLPKNPSPTTAISIVAGHTDSPCLKIRPVSKRETHGYLQIGVETYGGGTWPTWFDRDLGLAGRVIVAQDDGKFVSKLINLHRPLMRIPNLAPHLDRTLIDEMKINKETNIRPIAGLAAEILNEKKDKAETSNGEKKSGMQERHDPMLLKMIAEELDCGVEHIQDFELSLYDVQPAQVGGMSNEFIFAARMDNLMTSYSAIEALCEHATTSKTDDDNVHAVIVFDNEEIGSISNHGAESNILPSFVERIVAMPEFAEIGYQRMLAHSFLISADMGHALHPNYSDKYELNNSPKMNAGPVIKTNANGRYTSTAQTTFLLRQVAKKVGVPLQDYEVRNDSSCGSTIGPHLSTYLRTVDIGLATLAMHSIRETAGSADVRMYIDLFKGFFDHFAEIDKALKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ83</accession>
    <name>A0A1Y1UQ83_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transport protein Trs120 or TRAPPC9 TRAPP II complex subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_648816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874005.1">
        <property type="nucleotide sequence ID" value="XM_022017892.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UQ83">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ83"/>
    <dbReference type="GeneID" id="33559701"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ83"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="388"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="593"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="887"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1430"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1576" mass="171264" checksum="310D289A13C8A47F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQH7</accession>
    <name>A0A1Y1UQH7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase GCN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_273949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874105.1">
        <property type="nucleotide sequence ID" value="XM_022012346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQH7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQH7"/>
    <dbReference type="GeneID" id="33554154"/>
    <dbReference type="InParanoid" id="A0A1Y1UQH7"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="210" mass="23358" checksum="0938792452D9BEF6" modified="2017-08-30" version="1">MSSLTIRPFRSGDEPSLAKICCETGNNGKDGTGLLSDDRLWGDIWVLPYVKRDPQLAWVVEDLDGQVIGYTVGTDDSDAFNQWYKESWWPAESKKYERPPTSSGGPSREQTFFKIADETGSTPLNSSLREYPAHLHIDLLPPAQGKGLGRKMIRTLLQAMQDRGIKGVHLGASAENHSACAFYQKIGFGEVPTQDKGSRIFVWDLTKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQZ0</accession>
    <name>A0A1Y1UQZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_606412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874177.1">
        <property type="nucleotide sequence ID" value="XM_022014012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQZ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQZ0"/>
    <dbReference type="GeneID" id="33555820"/>
    <dbReference type="InParanoid" id="A0A1Y1UQZ0"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="753" mass="80506" checksum="905761F8F4EC1DB0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR13</accession>
    <name>A0A1Y1UR13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_648496</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873661.1">
        <property type="nucleotide sequence ID" value="XM_022017850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR13"/>
    <dbReference type="FunCoup" id="A0A1Y1UR13">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR13"/>
    <dbReference type="GeneID" id="33559659"/>
    <dbReference type="InParanoid" id="A0A1Y1UR13"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX39876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="109" mass="12400" checksum="55EDAD67C5395B90" modified="2017-08-30" version="1">MEVDQPVSASSGVVASGAEKKPRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQGAESEGCTVAWGICNHAFHFHCISRWLKTRHVCPLDNRQWELQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR16</accession>
    <name>A0A1Y1UR16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_576473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873709.1">
        <property type="nucleotide sequence ID" value="XM_022013191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR16"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR16"/>
    <dbReference type="GeneID" id="33554999"/>
    <dbReference type="InParanoid" id="A0A1Y1UR16"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="737" mass="83140" checksum="E6033444DB0D9766" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR43</accession>
    <name>A0A1Y1UR43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fms-interacting protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_5727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874202.1">
        <property type="nucleotide sequence ID" value="XM_022013054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR43"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR43"/>
    <dbReference type="GeneID" id="33554862"/>
    <dbReference type="InParanoid" id="A0A1Y1UR43"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23549" checksum="CA11D7891E55399C" modified="2017-08-30" version="1">MTLPSRIDEPSALDPLLLLPLPAKLPSSPLPTLEPLLSALEERLNQPGTSADGLAIFTAHMRQVTRRAQTLLNASRVGAAEARETLDRVDVDLRGVEYERDRIREEIAKCEDYEAAYTDIQVDDSFVPDSETLPAPDSDSYDYALIIARLQNELLEIEKREAAIASLTKDRDGIIQSKKDIKRKFDTSDVYLGDFAKTAAAMSSKVMDVAKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR53</accession>
    <name>A0A1Y1UR53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_6113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874209.1">
        <property type="nucleotide sequence ID" value="XM_022014256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR53"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR53"/>
    <dbReference type="GeneID" id="33556064"/>
    <dbReference type="InParanoid" id="A0A1Y1UR53"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="448" mass="51579" checksum="5AC9E868656587EA" modified="2017-08-30" version="1">MLYLTADKFPVFVPFGIIGFYRYLWYLIRLVAYGVYRPIPLPENPTYIASEDVTIIVPTIDAGEEFREAAFSWLEGDPKEIIIVTEERMRGPLQDLADSVDPSRIRVLTVPFANKRMQMSHGIRHTTTDIIVFADDDAIWPSTLLPYVLACFEDQQVGGVGTSQRVKPCGKRMTVWEVLAAFRLTIRNIEIASSTHIDGGIPCLSGRTAAYRTVILKDPDFLHGFTNDLWLGKYHLNSGDDKFLTRWMVSHGWNTYVQVCKEAELLSTMKPNWRFLKQVLRWTRNTWRSDFRSIFKERYIWTKHPYVAYMMLDKFINPFTLLVGPALVAYLIVKSTKDVLDGGYHLPAWNIVCSYLVWLMCTRTFKLLPHLWHNPAHIIYVPIWIIFGYYFAIMKLYAVLTLHKTGWGTRSGIGDPATATAAVLEKHDPPQRRSPPTPYDVEMNSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URB8</accession>
    <name>A0A1Y1URB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_614597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873470.1">
        <property type="nucleotide sequence ID" value="XM_022014619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URB8"/>
    <dbReference type="STRING" id="4999.A0A1Y1URB8"/>
    <dbReference type="GeneID" id="33556427"/>
    <dbReference type="InParanoid" id="A0A1Y1URB8"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="144"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX39685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="494" mass="54629" checksum="C1AC208B27B602D6" modified="2017-08-30" version="1">MVAGLKIHHAEEYELGNTDATAGPSSRVRNTHGGHRSTGSSSVLFDVSSSSPSDQRDAGARPYLSPRILRRQSLPPPPDSPLTPKRSYRAQFLEDEGIDIPNISGILGLDDDKDRFAVATGMSSVPKKRVYLLMEEPSSSREAFYIHISVTGIILFSALLTMLSTLPTFHTDPISAKILFALDIFLVLLFTAEFACRVYGHSDSWTQLRDWLCSFLTWIDLSAILPFYVELALKSDTSAYRWSILRVFRLLRVFRSFSHSSSLLLTMEAMFVAVKKSSNALLSMAFFLIIVILTWSVLVWTAERGEWDENLQLFVSQNGEPSQFTSIPIAAWYVLTTISTTGYGDFVPVSAVGRLLTVPLLVFGLLLLALPSFVLGRNFSIVFDAMERERHTIHRPGATRTPSNRSSADGPAMTNLLTETPTIRRPTPIPVSNPAGDDISNIKLAKNQVALMDQIEALRRTLDQQGAMLRSLVSALDASKSQTPNGYPPGDHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URH1</accession>
    <name>A0A1Y1URH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_606450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874238.1">
        <property type="nucleotide sequence ID" value="XM_022014015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URH1"/>
    <dbReference type="FunCoup" id="A0A1Y1URH1">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URH1"/>
    <dbReference type="GeneID" id="33555823"/>
    <dbReference type="InParanoid" id="A0A1Y1URH1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000004">
        <property type="entry name" value="NAD kinase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="721" mass="79520" checksum="CFAFC3618B184D9C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URJ7</accession>
    <name>A0A1Y1URJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_574985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874370.1">
        <property type="nucleotide sequence ID" value="XM_022013096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URJ7"/>
    <dbReference type="STRING" id="4999.A0A1Y1URJ7"/>
    <dbReference type="GeneID" id="33554904"/>
    <dbReference type="InParanoid" id="A0A1Y1URJ7"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="791"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="878"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="963" mass="104362" checksum="DDF30289F252C660" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URL2</accession>
    <name>A0A1Y1URL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_611393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874261.1">
        <property type="nucleotide sequence ID" value="XM_022014261.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1URL2">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URL2"/>
    <dbReference type="GeneID" id="33556069"/>
    <dbReference type="InParanoid" id="A0A1Y1URL2"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="1463"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1750"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="2029" mass="225167" checksum="53A7A4E1BE5A8FF9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URS6</accession>
    <name>A0A1Y1URS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ras GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_576164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873650.1">
        <property type="nucleotide sequence ID" value="XM_022013175.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1URS6">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URS6"/>
    <dbReference type="GeneID" id="33554983"/>
    <dbReference type="InParanoid" id="A0A1Y1URS6"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="330"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="929"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1739" mass="195594" checksum="410745FCBBC7CC6F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URU8</accession>
    <name>A0A1Y1URU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD324DRAFT_611738</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874351.1">
        <property type="nucleotide sequence ID" value="XM_022014302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URU8"/>
    <dbReference type="FunCoup" id="A0A1Y1URU8">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URU8"/>
    <dbReference type="GeneID" id="33556110"/>
    <dbReference type="InParanoid" id="A0A1Y1URU8"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="54"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="504"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="59"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="448"/>
            <end position="449"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ORX40672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="640" mass="69911" checksum="8603D5AE9B0D09EE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URV5</accession>
    <name>A0A1Y1URV5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_611768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874361.1">
        <property type="nucleotide sequence ID" value="XM_022014306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URV5"/>
    <dbReference type="FunCoup" id="A0A1Y1URV5">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URV5"/>
    <dbReference type="GeneID" id="33556114"/>
    <dbReference type="InParanoid" id="A0A1Y1URV5"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000150">
        <property type="entry name" value="Actin-related protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX40682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="390" mass="44114" checksum="93C412FC0CA79DFA" modified="2017-08-30" version="1">MAESRPLVVDNGTGFVKCGYAGSNFPEFVFPSVVGRPILRAEERTGSSSIRDLMIGDEAAENRSFLQMTQPMEHGVVKNWEDMKHLWDYTFDEKLKVDTHGQKILLTEPPMNPKVNRQKMCQVMFEEYGFGGVYVAIQAVLTLYAQGLQTGVVVDSGDGVTHIVPVYDGFALPHLTKRLDVAGRDVTRYLIKLLLMRGYAFERTADFETVRGIKEALCFVSYDLEQDKKLSEETTTLVENYTLPDGRVIKVGSERYEAPECMFQPHLVDLEQPGVAELLFQTITQAAVDIRPELYKHIVLSGGSSMYPGFPSRLEKEMKQLYLTRVLGGDGSRLKNFKIRIEDPPRRKHMVFLGGAVLADIMKDREEFWVTKAEWDEQGVRALDKLGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URY2</accession>
    <name>A0A1Y1URY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_612122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874469.1">
        <property type="nucleotide sequence ID" value="XM_022014357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URY2"/>
    <dbReference type="FunCoup" id="A0A1Y1URY2">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URY2"/>
    <dbReference type="GeneID" id="33556165"/>
    <dbReference type="InParanoid" id="A0A1Y1URY2"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000005">
        <property type="entry name" value="Exosome complex component RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="32"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="191"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="281" mass="31126" checksum="7609E55C68B0599A" modified="2017-08-30" version="1">MPREIEPSINQREFVLRALAQGKRLDGRVPLELRNVELEFGDELGWCTARLGKTAVLAHVSATIVRPRDDRPYEGFLIINSEISPMASSVYEAGRASEDEVLITRLLEKSIRRTEAVDREALCIIAGEKVWQLRLTLHFLSDSGNILDCASIAAMTALRHFRKPEVEVSGRDVIVHSPDERAPVPLAIHHTPLCVSFAFFPDLPPIIDPTHLESVLSSGTLTLTLNAQRELCVLSKAGGSALSPGEIMGVVRVGVERVRELVKIMEDALRSDQSNRVIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USA2</accession>
    <name>A0A1Y1USA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 88-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_596489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874580.1">
        <property type="nucleotide sequence ID" value="XM_022013866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USA2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USA2"/>
    <dbReference type="GeneID" id="33555674"/>
    <dbReference type="InParanoid" id="A0A1Y1USA2"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="524" mass="57921" checksum="432DD386C892E130" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USJ5</accession>
    <name>A0A1Y1USJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_575168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874296.1">
        <property type="nucleotide sequence ID" value="XM_022013110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USJ5"/>
    <dbReference type="FunCoup" id="A0A1Y1USJ5">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USJ5"/>
    <dbReference type="GeneID" id="33554918"/>
    <dbReference type="InParanoid" id="A0A1Y1USJ5"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="187" mass="21213" checksum="1422CA5990000E34" modified="2017-08-30" version="1" fragment="single">QHGQPAPLLPVMDRVHSGRKCLVLDLDETLLHSSFKMLPNADYIVPVEIEGQTHNVYVIKRPGVDNFLKEMGRLYEVVIFTASLSKYADPVLDMLDVNRVVRHRLFRESCYNHKGNYVKDLSQLGRDIHETIIIDNSPASYIFHPNNAVPVSTWFNDPHDTELTDLCPFLTDLSTVTDIRGVLDGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT03</accession>
    <name>A0A1Y1UT03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_613381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874819.1">
        <property type="nucleotide sequence ID" value="XM_022014492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT03"/>
    <dbReference type="FunCoup" id="A0A1Y1UT03">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="GeneID" id="33556300"/>
    <dbReference type="InParanoid" id="A0A1Y1UT03"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF23">
        <property type="entry name" value="DUF726-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX41140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="80169" checksum="96B7466B596A67A4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT66</accession>
    <name>A0A1Y1UT66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_44140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874821.1">
        <property type="nucleotide sequence ID" value="XM_022012795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT66"/>
    <dbReference type="FunCoup" id="A0A1Y1UT66">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UT66"/>
    <dbReference type="GeneID" id="33554603"/>
    <dbReference type="InParanoid" id="A0A1Y1UT66"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="144" mass="16277" checksum="E8913E327F3DAD7C" modified="2017-08-30" version="1">MTQDLTRFIEYREAFALFDKRGTGQLPKETLGELLRSLGQNPTQAEVQQLQGQVGNTFDYDHFLQILNRPDGWKPAGTADEFIKGFQVFDKAGNGFIGAGELRYVLTQLGEKMSDEEVDELLKGFQVQDGQINYHSFVRSILAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT80</accession>
    <name>A0A1Y1UT80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874506.1">
        <property type="nucleotide sequence ID" value="XM_022017709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT80"/>
    <dbReference type="GeneID" id="33559518"/>
    <dbReference type="InParanoid" id="A0A1Y1UT80"/>
    <dbReference type="OrthoDB" id="2564719at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="344" mass="35485" checksum="3A00F3838D24374C" modified="2017-08-30" version="1">MSSNSRSHSHSRSPNPSRDSCAHRAAAGVAHLTSSKSPSNLASNRVQPSLDRHARSNSRHTSPDRRPGTQRSRSAPSPQSRTVPPPPSTHPPPLAIAPSTGAVNLPSRANMMAFNPYMGMMGGAPGAGSYSNMGMGGPFDPRMSMIGQYPMMSGMGGPMPHAGGTPGVGPGSGAMNSDGSLKPFDSSQMKRGRMGHYGYLEGRELAGPPPGHLPAGMSPMYDQGLSTQGPTSQIMGSPTDTGSGTAPSSAGYYPQTAAGGATGRTGPKTSWGDPNVGPRARYDGTSATQQIVQADVDSPYPLTARGGVASAFTKYEGYGPERAAASGIDGRLGWAHRRTREGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UT85</accession>
    <name>A0A1Y1UT85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_648119</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874918.1">
        <property type="nucleotide sequence ID" value="XM_022017784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UT85"/>
    <dbReference type="STRING" id="4999.A0A1Y1UT85"/>
    <dbReference type="GeneID" id="33559593"/>
    <dbReference type="InParanoid" id="A0A1Y1UT85"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05573">
        <property type="entry name" value="STKc_ROCK_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="448"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="801"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX41239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="928" mass="103765" checksum="16FB6C7603BE8031" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTF4</accession>
    <name>A0A1Y1UTF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene/phytoene synthase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_612154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874483.1">
        <property type="nucleotide sequence ID" value="XM_022014361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTF4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTF4"/>
    <dbReference type="GeneID" id="33556169"/>
    <dbReference type="InParanoid" id="A0A1Y1UTF4"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="366" mass="40947" checksum="DDBF190BD433CF2D" modified="2017-08-30" version="1">MNFDLGLQHLVVISAIIMSVKWSLTSVASASRPGSISRRCFSAIPARLGGQSPAKPSLNVQVASGGPQAPSEYCASLVRKLDPEAWLCSYFWPRRERSWWLAWRAFNIELHLISTTVTVPGLAAIRYQFWRDTLSVIWTGKTAHGQVLAVPQHPIAIMLEQMKRSRPIQRYYLSQMIDVREKIQDQAASSSSLESHLATHGPLQSSLLLGSLPLLIPPNDPKTSELTHTLSHLSNLLTTASLIRNLPVLVKSKREINLPRDICAKHSIVDEEVIRQAGNAKGLKDACYEIGTRGMDELITARRDLKSSGGKIEPTAAFPVFLASVPAERYLKRLEKVDFNPFHRSLERHDWQLAPRIWWTAQTGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTQ7</accession>
    <name>A0A1Y1UTQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874254.1">
        <property type="nucleotide sequence ID" value="XM_022017670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTQ7"/>
    <dbReference type="GeneID" id="33559479"/>
    <dbReference type="InParanoid" id="A0A1Y1UTQ7"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666044" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="45772" checksum="6DD9A695175CBD4E" modified="2017-08-30" version="1">MSILAALAKLVLVLAAGSEVLALPTTRSQQLVTRTTNPTVSESNLAAISLDPNYQRDSCVSATSLINGRVLWVCRDTQVLVDESIDDEFNGQAGDFVSSSASWSDQLGTQPHLVPIPSNQGQQQATSGYPAQLTMYGGDTTSTSFLPYASDECDQNGNQAGTGGTCASDGTRYPLWIDSPPYVYQGSDGSATAYVYMMRTHIQGLTNLASTFPTSLYQINYDSSSSSNSLPSVELINEYWFPDGVFNYGDFGGITGTLDGKLYLYGQGLSKSNNGHQPVALARCSNPTDLSTYEYYYNDGTWSTTQAQVDDQSAWLDGEFGKGGTFFYSDYTNSYLWIGQPTGAIGATVMVSSASSPEGPWSTPTQIANLPSGDSYAYSVAAHPEMSSNSQQIYLTYTLQKFYDGNSNDIYYEQPLYMFTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTS0</accession>
    <name>A0A1Y1UTS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_647724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874495.1">
        <property type="nucleotide sequence ID" value="XM_022017706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTS0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTS0"/>
    <dbReference type="GeneID" id="33559515"/>
    <dbReference type="InParanoid" id="A0A1Y1UTS0"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 5">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="159" mass="17653" checksum="BF0D9F84B11F633D" modified="2017-08-30" version="1">MLNGKKSVLVINGPNLNLLGIREPHIYGYETLDDVVKAGKAQGQADGAHVDFFQSNWEGAAVDRIQEARTDGTDAIVFNPGGWTQTSVPIRDALLGVAIPFIELHVANIHAREEWRHHSYFHDKATCVIMGCGIKGYEYAIDMIIKNDKKFPPKPDVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU39</accession>
    <name>A0A1Y1UU39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874743.1">
        <property type="nucleotide sequence ID" value="XM_022017752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU39"/>
    <dbReference type="GeneID" id="33559561"/>
    <dbReference type="InParanoid" id="A0A1Y1UU39"/>
    <dbReference type="OrthoDB" id="2563669at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="637" mass="68262" checksum="691C92E425DC17E4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UV40</accession>
    <name>A0A1Y1UV40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Epidermal growth factor receptor-like transmembrane-juxtamembrane segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_613119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874764.1">
        <property type="nucleotide sequence ID" value="XM_022014471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UV40"/>
    <dbReference type="STRING" id="4999.A0A1Y1UV40"/>
    <dbReference type="GeneID" id="33556279"/>
    <dbReference type="InParanoid" id="A0A1Y1UV40"/>
    <dbReference type="OrthoDB" id="2565167at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment" evidence="10">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX41085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="356" mass="34660" checksum="2ABD4FC56E745158" modified="2017-08-30" version="1">MSSSSSAQSSSSSPTTTSSSSAVESSSTTASSSSSTAQSSTSTAASSSSTSTTSSNAASSSTSSSTTSSGSSATSTTSSSSSSAQVETKTITYTSTQANGSVVTGTAVSTGISNDSSSGGGGGTNTGAIVGGVVGGVAALVILAALAWFLIRRRRKSHRAEFDDMMFDPSRAQNHGAIDLADNSVSPYVAPGVASTAQSPEMTQYARSATSDGNYGYNDQNLPTRNPSSATSSAGFAGRGAGGYPHGMSGSPPPMPTIPAGAEAAGYGAAAGAGAGAAAGGAMSSKQREAYHEQQRLRVANQGGYSGGYNHQPGAPSSSGAMEGEPGSPGSGGPVTVHEDGGAASEIPPTYDSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5G5</accession>
    <name>A0A1Y1U5G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_640331</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="NBSH01000029">
        <property type="protein sequence ID" value="ORX33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867631.1">
        <property type="nucleotide sequence ID" value="XM_022017336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5G5"/>
    <dbReference type="FunCoup" id="A0A1Y1U5G5">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U5G5"/>
    <dbReference type="GeneID" id="33559145"/>
    <dbReference type="InParanoid" id="A0A1Y1U5G5"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="236"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="463" mass="53110" checksum="2050DE496E715BB6" modified="2017-08-30" version="1">MVASIVDSLDGAINHLAYLADDPRIDYQSVVVWSSFLTTAFEVWLNRRQLRQYDKPKPPPELASHISDDKFRKAQAYGRDKTRYSLFKAVFNQILGWAIIRSRLYAKLWYVTGGWMDTLGLAPSRTIVHSMMWISTLVVFSTIPSIPWNYYYTFVLEEKHGFNKSTLKLWIMDQIKSTVLLAAIGLPILAAFLKIIELAGRRFVPWLMLFLITVQLSMQMIYPTFIQPLFNKLTPLPEGELRTRVENLAAKLKFPLNHLYVIDGSKRSGHSNAYFYGLPWSKHIVIYDTLMEQSSPAEVEAVLGHELGHWSYTHPTKLLLIIQLHLLTTLTTFSIFIHNRALFDSFGFDPQLAITGVAGGPQPIIIGFMLFQLVLEPQDTVVNFLIHALTRKYEYQADEFAVKLDKKEDLASALIKLHIDNLSAPHNDKLYSMYHHSHPTLPERLRAMETYVRAVDVQGKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6H2</accession>
    <name>A0A1Y1U6H2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_584701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867939.1">
        <property type="nucleotide sequence ID" value="XM_022013699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6H2"/>
    <dbReference type="FunCoup" id="A0A1Y1U6H2">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6H2"/>
    <dbReference type="GeneID" id="33555507"/>
    <dbReference type="InParanoid" id="A0A1Y1U6H2"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="487" mass="54412" checksum="6C841951D92E1DE4" modified="2017-08-30" version="1">MAKRRKNRTHLKGAAKGEEEENVPKSFVIKSGVVTKSISALVRDVRKLMEPNTASRLRERPSARLRDYLTIGPTLKVTHLLAFTLTDAANVHLRMARLPQGPTLTFRVQRYSLMRDLVHSSLRNIGKAPGGEYRHPPLLVLNGFQQPADGPAMPQLRLMSTMFQGLFPAIQVEKSALPNFRRVLLLSYHHTTHLISLRHFTIIVRPHGVSRRVRKLVNGNAAATSRRPDLSAADDIADYLLKRITSSASDGMSVGTGGYDSMSETEASEGESDTNAVELPEDYVGRGNRKGERKAVRLVETGPRMELRLIKVVEGLVGSKRGEGETVFHEFEHKTKAEASHLAKVHAEQRKIREARRAEQAANVARKKAEKAKTKGKGEPVSEEEEEEMDGHELDVEGLSGDEDPEEALQRLQRRSRAAEEDDDEFEYEDRIAGDRQDEGEDDDDEEWDEDVGADDVSSEGEDLGDESSEEEDDVPHLPAKKSVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U723</accession>
    <name>A0A1Y1U723_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_638825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868138.1">
        <property type="nucleotide sequence ID" value="XM_022017160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U723"/>
    <dbReference type="FunCoup" id="A0A1Y1U723">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U723"/>
    <dbReference type="GeneID" id="33558969"/>
    <dbReference type="InParanoid" id="A0A1Y1U723"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000242">
        <property type="entry name" value="53 kDa brg1-associated factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="463" mass="51093" checksum="3F4F46C531FA9FE7" modified="2017-08-30" version="1">MVYNGDEVSAIVVDFGSHTTRAGYAGEDCPRVVCPSFYGYTEESDASTSSGAANGNGEDVPMDGSVVNGSKGKRRYYVGESGVPVWRKGMEVDNFMLDGIVHELEPAAQLLHHLLTDRLSVDPTEHPLMFTEPAWNTPASRENLTRMAFEQEGVPALYFGSSGVLSAFAAGKPTALVLDVGYANTSVVPVVDGYALRAGTKRQPLGSALLLSQLQHHFKSPTSSRNFPLTLTPRQLLAKRDPTPESGMQVNPVLRTDRVSNTTPSWRHWAEGSVVEGWKESCAEVINYKGFDFQTARELPQTLYEFPDGYQQQFGEERYRFTEMLFDPKNYFDQSIEPPAGLRVVQSGDHAHSLKDLVPLSQLVHDSIMACDVDVRAALLQNIVVVGNTSLIKGLTERLDLELAALMPSQKIKIHSPTIPFEKKFSSWVGGSVLASLGTFHQLWVTKDEYEEHGMAIVHQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7C3</accession>
    <name>A0A1Y1U7C3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_683759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868196.1">
        <property type="nucleotide sequence ID" value="XM_022019200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7C3"/>
    <dbReference type="GeneID" id="33561009"/>
    <dbReference type="InParanoid" id="A0A1Y1U7C3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="548" mass="57064" checksum="C0FDBAB76098B29E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7I2</accession>
    <name>A0A1Y1U7I2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_643669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868278.1">
        <property type="nucleotide sequence ID" value="XM_022017564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7I2"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7I2"/>
    <dbReference type="GeneID" id="33559373"/>
    <dbReference type="InParanoid" id="A0A1Y1U7I2"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="35398" checksum="A6233403283AFB60" modified="2017-08-30" version="1">MQYEPLSDPLLPGQVLPPWARDKLSAESKECISRLLAHEPSPTRDCGMVKQSAVLVALFQPEGCDELRVLLTTRAKTMRTHPNQTALPGGRVDQEDHSPVHTAYREANEEVGLPLPPHPHIHHLTVLDPLITILPLNAALRNHIIVIPVICFISDQRLISSLVPSPSEVGHIFSHRLKSCHSGIVPENEFASLAEKDGEWWPHPEDMHSQDNRLGVMGPYRMHRFRTTHSPIKGVTSDVLINTATLAYGTPPSFTRFAPGQLSSEQVIERVVAELPLALAKESALSPEERTGLKALPLEWGNLESGERVKSGETWHDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7P4</accession>
    <name>A0A1Y1U7P4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868339.1">
        <property type="nucleotide sequence ID" value="XM_022013662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7P4"/>
    <dbReference type="GeneID" id="33555470"/>
    <dbReference type="InParanoid" id="A0A1Y1U7P4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="525" mass="57474" checksum="86B847A7D1B43A9D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7P5</accession>
    <name>A0A1Y1U7P5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_585044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000020">
        <property type="protein sequence ID" value="ORX33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867854.1">
        <property type="nucleotide sequence ID" value="XM_022013718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7P5"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7P5"/>
    <dbReference type="GeneID" id="33555526"/>
    <dbReference type="InParanoid" id="A0A1Y1U7P5"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="141"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="637" mass="70339" checksum="F116998CB2C01E2A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7V1</accession>
    <name>A0A1Y1U7V1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RAVE protein 1 C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_217020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867915.1">
        <property type="nucleotide sequence ID" value="XM_022012201.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U7V1">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7V1"/>
    <dbReference type="GeneID" id="33554009"/>
    <dbReference type="InParanoid" id="A0A1Y1U7V1"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="695"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1464"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1565" mass="172982" checksum="97153771932D427F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8T0</accession>
    <name>A0A1Y1U8T0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_643408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868696.1">
        <property type="nucleotide sequence ID" value="XM_022017542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8T0"/>
    <dbReference type="FunCoup" id="A0A1Y1U8T0">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8T0"/>
    <dbReference type="GeneID" id="33559351"/>
    <dbReference type="InParanoid" id="A0A1Y1U8T0"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010987886" evidence="5">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="43509" checksum="501CE8938EB17CE2" modified="2017-08-30" version="1">MSLTSISLFCILAVLANASPVPNQPRSVYTLREGKPRLSFQERATVSGKSIQELLAIDRANVVAKYEHNNKLAAAAKASGLLTKSKRQSTIGLTDVNSGGVDELYYGTLQIGTPSQDITFDFDTGSSDLWVPTQNSNGYNDGTHFNTAASSTFQSTGQSFADQYGSGTCSGTLATDTVSFGSLTANPQYFGAVTQVSSSFDNNPATGLCGLAYQSIASSGQAPLPLNLYNSGQISSPEFGFRITADTSNGAELTMGGIASDYAGASFQSTPVTTQTYYEVNTNGITVNENIVSGSFPAAIDTGTTLIYVPTSAASAFYNAIPGSSSAGNGAYNYPCDFSGTVGFNFPNIGNLDFNVNDLNAGNNGDGTCVGAVQGQDIQDTNGNDFAIIGDVFIKSYYTVFNFGSNYVAFSPANGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U922</accession>
    <name>A0A1Y1U922_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_637997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868294.1">
        <property type="nucleotide sequence ID" value="XM_022017067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U922"/>
    <dbReference type="STRING" id="4999.A0A1Y1U922"/>
    <dbReference type="GeneID" id="33558876"/>
    <dbReference type="InParanoid" id="A0A1Y1U922"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54999" checksum="0E0A2B08490C540C" modified="2017-08-30" version="1">MSSNSREHISTVGTATSTHYLEHINGWPHYVSTTVAFRKDLAPSREWLADHLSQAQKRYPDLRLEFVNLPRPSGHEGVWSSIHWKLREKPWALDDVYTELPDVPSSTLEAWQIALEIAEKESLVSRPLWMIQRMTAADTVYLSFTMSHKFLDGLGMVNLVRILLTPNFDGLPDETDLGHFVKNLEIPSKVIPEKPYEPWTPRPQPETTEAPIWPHAPEDYGHLISLDHPQIFEELDLPADDVMAISRNAKSHQIPTLNPVLLASFLQALSEELDVHRRFQYIVPIGTRKSTDPFFFSGYSTAVFPVTSPKPHEKILWEVAKEVADGIKAALDESNAPPPPPAPAPAETKDEAENIEDGTSPAMADPPAIATEQPEFSPESSWKRMQEIMQSERFYKFSMVFSNLTRLPWLNDIRGVDDFLWGQSMNICPAPFIINLVGWKGGVRATVGFRDGCGVSAAQGEQIAKRWRRILAAAATDEDIVNGTEKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U926</accession>
    <name>A0A1Y1U926_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_594336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868793.1">
        <property type="nucleotide sequence ID" value="XM_022013828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U926"/>
    <dbReference type="FunCoup" id="A0A1Y1U926">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U926"/>
    <dbReference type="GeneID" id="33555636"/>
    <dbReference type="InParanoid" id="A0A1Y1U926"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="338" mass="37379" checksum="955ABD4AEB0A4716" modified="2017-08-30" version="1">MYSYWLSSHLWAPALTCHSSLLSNRSGTVVVSDSGDFEAIGAYKPQDATTNPSLILAATKMGSYDKVINAAVEYAKKKGGDIDVQSENALDALLVEFGKEILKIVPGRVSTEVDAKFSFDEQGTINKAHQIIKLYEEAGISKDRVLIKIASTWEGIHAAEKLEKEGIHCNLTLLFGFAQAVACAEAGVTLISPFVGRILDWYKKSTGEEYTAETDPGVKSVQRIFNYYKQHGYKTIVMGASFRNVGEIKELAGCDYLTIAPKLLEELQKSNDDVPKKLDASTSHQASEEKVSFLNDEPAFRWQLFDDNMAFDKLHEGIRGFAKDGATCKDMLKKKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9E4</accession>
    <name>A0A1Y1U9E4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sec63 Brl domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_636904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868442.1">
        <property type="nucleotide sequence ID" value="XM_022016948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9E4"/>
    <dbReference type="FunCoup" id="A0A1Y1U9E4">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9E4"/>
    <dbReference type="GeneID" id="33558757"/>
    <dbReference type="InParanoid" id="A0A1Y1U9E4"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="666"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="748" mass="82976" checksum="21D4FBD19E491D5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9N0</accession>
    <name>A0A1Y1U9N0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_130558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868981.1">
        <property type="nucleotide sequence ID" value="XM_022011988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9N0"/>
    <dbReference type="GeneID" id="33553796"/>
    <dbReference type="InParanoid" id="A0A1Y1U9N0"/>
    <dbReference type="OrthoDB" id="2594273at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="269" mass="30148" checksum="8A750DD8C991511B" modified="2017-08-30" version="1">MADRVVVHRCHVRFLPFANCPTSALLDHAPATECFFRLRHTSDALEMEVDSLQDENAQLRARLASLQASRTASSDIIPPPPSASSVLKPSSVTQDGTLIDYGYLEKIQTELRSFRNQLMEKEDTLSRLRGEQAVSPDMWAQREALLGDYTTLKTLQAEAAGLESLVTILDKEKDEIIKQTEIIHRELVARGIGAGHGVQNTRVQIEDVDEEEDILQEQEEEEEEEEEEEEPVEENGQVVQKALADIRGWVDAAVRDWAEVSGASLSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9N9</accession>
    <name>A0A1Y1U9N9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_634836</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868992.1">
        <property type="nucleotide sequence ID" value="XM_022016761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9N9"/>
    <dbReference type="FunCoup" id="A0A1Y1U9N9">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9N9"/>
    <dbReference type="GeneID" id="33558570"/>
    <dbReference type="InParanoid" id="A0A1Y1U9N9"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="400"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX34750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="555" mass="62776" checksum="D6881FEAB052CDC6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA16</accession>
    <name>A0A1Y1UA16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_653107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869094.1">
        <property type="nucleotide sequence ID" value="XM_022018608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA16"/>
    <dbReference type="GeneID" id="33560417"/>
    <dbReference type="InParanoid" id="A0A1Y1UA16"/>
    <dbReference type="OrthoDB" id="2563693at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="729" mass="81376" checksum="A6EA5D5DDD69462F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA22</accession>
    <name>A0A1Y1UA22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_609997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868619.1">
        <property type="nucleotide sequence ID" value="XM_022014182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA22"/>
    <dbReference type="GeneID" id="33555990"/>
    <dbReference type="InParanoid" id="A0A1Y1UA22"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="870" mass="98334" checksum="A1E69FE2F68F4132" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA34</accession>
    <name>A0A1Y1UA34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_637764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868233.1">
        <property type="nucleotide sequence ID" value="XM_022017044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA34"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA34"/>
    <dbReference type="GeneID" id="33558853"/>
    <dbReference type="InParanoid" id="A0A1Y1UA34"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="685" mass="74820" checksum="21BB09E76D8628C3" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA42</accession>
    <name>A0A1Y1UA42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD324DRAFT_635602</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868639.1">
        <property type="nucleotide sequence ID" value="XM_022016827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA42"/>
    <dbReference type="FunCoup" id="A0A1Y1UA42">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UA42"/>
    <dbReference type="GeneID" id="33558636"/>
    <dbReference type="InParanoid" id="A0A1Y1UA42"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="459"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ORX34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="764" mass="87286" checksum="8E78005FBB22FD72" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA51</accession>
    <name>A0A1Y1UA51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal oxidase N-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_609667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869114.1">
        <property type="nucleotide sequence ID" value="XM_022014163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA51"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA51"/>
    <dbReference type="GeneID" id="33555971"/>
    <dbReference type="InParanoid" id="A0A1Y1UA51"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012824426" evidence="3">
        <location>
            <begin position="24"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="497"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="684" mass="72301" checksum="8406EDA26C5CAC77" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UA87</accession>
    <name>A0A1Y1UA87_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_106718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869154.1">
        <property type="nucleotide sequence ID" value="XM_022011921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UA87"/>
    <dbReference type="STRING" id="4999.A0A1Y1UA87"/>
    <dbReference type="GeneID" id="33553729"/>
    <dbReference type="InParanoid" id="A0A1Y1UA87"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="64711" checksum="BD05052268ACB450" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAK6</accession>
    <name>A0A1Y1UAK6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_582686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869258.1">
        <property type="nucleotide sequence ID" value="XM_022013575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAK6"/>
    <dbReference type="FunCoup" id="A0A1Y1UAK6">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAK6"/>
    <dbReference type="GeneID" id="33555383"/>
    <dbReference type="InParanoid" id="A0A1Y1UAK6"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="421" mass="46336" checksum="F4D80C7949CBBE0D" modified="2017-08-30" version="1">MGLVRLVLCVSGVYATFLLWAIAQERLSTPFPSSDRRTGTPHSYHYTSLDQFPSSVFLNYAQAVASSLSALVYLVVGSWRDGSWKRKGLGGVTGWKQFWSSSDSLAKSKGDSDNAGISNGHSRERKQPNGGFVEQKNPVVKQTPQGKALPFLLLQVAASQTFAGPVGFLSLRHISYPTMVLGKSCKLIPVMLLNLILYRRRFAMHKYVVVGLVTLGISLFMLFGSKKKKGGADSLWGLTLLLVNLMLDGMTNSTQDQIFTLFPSFTGQQMMLAMAVSTQLILLPLLLLPLPSNLSTILSILPFTSSSVPNHPITFSQPAFTQSIQFLLSHRSAIRPLLAYALLGGLGQLFIFETIQHFGSLTLVMITVTRKLFTMLLSVIIFNHSLTTGQWTGIAVVFSGIGLEAGIKRRDMMRRARRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAL0</accession>
    <name>A0A1Y1UAL0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_161342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868847.1">
        <property type="nucleotide sequence ID" value="XM_022012060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAL0"/>
    <dbReference type="GeneID" id="33553868"/>
    <dbReference type="InParanoid" id="A0A1Y1UAL0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="95" mass="10352" checksum="1EB1FA68C4FAFB89" modified="2017-08-30" version="1">MKGYLLSPDNWLCGYSDSQCTCAPYCRCKTFEPCCISCCYRVPSGLHHVPEHILRQLQGLPPTSNMGSSAYLTSSAGTMMPGSDEKVSKGCCMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAR0</accession>
    <name>A0A1Y1UAR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_634032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869357.1">
        <property type="nucleotide sequence ID" value="XM_022016693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAR0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAR0"/>
    <dbReference type="GeneID" id="33558502"/>
    <dbReference type="InParanoid" id="A0A1Y1UAR0"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="161"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="329" mass="37777" checksum="EB5EE3597ECDCD43" modified="2017-08-30" version="1">MSDDHTFHLSCHCQSNILRITYPADTEPFNKNQVCDCSYCLKKRIVWSIAPAGSVKVLRGFDKLRDYQFGGKNMHHRWCGECGSNLVATYKDANLNFDMPMYFNMRNIRDDHFDLWKYPVTPINFSQAGDKYNHPELSDIPGAQEYLEKRAQGRDGPTEILLGSCHCKAIKFALIDSPLGTTRMNDCACSICLGNGSLWIYPPRQDFFFSPSAPDEPYHPHPDSTFDYGYYKKENLMYHCRECGCNLFELEPPEGLAKYPLEKQRLGVNASLLTNISDYFEDVSGLSWDDEKRKEGYESKTKTLESMRRGRTMKLAGPPHYKLDLSEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAR1</accession>
    <name>A0A1Y1UAR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_646594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869339.1">
        <property type="nucleotide sequence ID" value="XM_022017630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAR1"/>
    <dbReference type="FunCoup" id="A0A1Y1UAR1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAR1"/>
    <dbReference type="GeneID" id="33559439"/>
    <dbReference type="InParanoid" id="A0A1Y1UAR1"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="123" mass="13605" checksum="6817AF4F4BC59AA9" modified="2017-08-30" version="1">MSTQPLLQRTAKKRIALPVRVEPKVFFANERTFLSWLHFAVVLGGLAVGLLNFGDKVGKISAGMYTIIAMAVMLYALTVYQMRARAIRLRTGAPYDDRLGPTVLCVCLLAAIITNFVLKAVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAX0</accession>
    <name>A0A1Y1UAX0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial distribution and morphology proteins-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_604121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868898.1">
        <property type="nucleotide sequence ID" value="XM_022013973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAX0"/>
    <dbReference type="FunCoup" id="A0A1Y1UAX0">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAX0"/>
    <dbReference type="GeneID" id="33555781"/>
    <dbReference type="InParanoid" id="A0A1Y1UAX0"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="715" mass="79452" checksum="30A98B57A0405500" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAY1</accession>
    <name>A0A1Y1UAY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_609885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868946.1">
        <property type="nucleotide sequence ID" value="XM_022014177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAY1"/>
    <dbReference type="GeneID" id="33555985"/>
    <dbReference type="InParanoid" id="A0A1Y1UAY1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="224" mass="24173" checksum="CC3334CFD0C3CD9D" modified="2017-08-30" version="1">MHTKARTKADIRNASIEHAVRHYNAFISPYSYGSCLPAYPNHNVHRYLTIMPSIGSPFIDPYSQSGMGGMGMMNPMMMGMMNPMMMGMMNPMMMGGYGMMGGGLGSGAYGQIALVFLIKHRYPSNSVQCKSCHSFSTHHAVPVPTSWSSTDAKVSTGRAGRQSDACPTAKILSAVRTPSRVSSMRARPVAPFLAFPSLSCLLVSLHCQTGLSAPDIHPVTSYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB30</accession>
    <name>A0A1Y1UB30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_642956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869419.1">
        <property type="nucleotide sequence ID" value="XM_022017518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB30"/>
    <dbReference type="FunCoup" id="A0A1Y1UB30">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB30"/>
    <dbReference type="GeneID" id="33559327"/>
    <dbReference type="InParanoid" id="A0A1Y1UB30"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="734"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112353" checksum="F487EF30599897C2" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBD9</accession>
    <name>A0A1Y1UBD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="9">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_642998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="9"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869529.1">
        <property type="nucleotide sequence ID" value="XM_022017521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBD9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBD9"/>
    <dbReference type="GeneID" id="33559330"/>
    <dbReference type="InParanoid" id="A0A1Y1UBD9"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012440523" description="Alpha-L-arabinofuranosidase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="12">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="11">
        <location>
            <begin position="364"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="86"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="399"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX35339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="504" mass="53879" checksum="A069933375745B3E" modified="2017-08-30" version="1">MDLISSALPIRLLHALGLAAVAPGVCDIYASGDTPCVAAHSTTRALYSSYRGPLYQVTRGSDDKTVDITPLKVGGVANSRIQDKFCRATTCEISIIYDQSGNQNHLTRAPGGGADIGEYPGGYDILASAVAAPVTVQGHKVYGVFTPQGAGYRCNTPTNVPVGNEAEGIYAVLDGTHYNGECCYDYGNAETTTNDEGKTTMETIYFGGGNEYVDGHEAGPWVMADLEDGLFGSDIRGKVPAQPPLNHRFVMGIVKGANYNLWTIRAGDASAGSLHTAYSGRRPEGYYPMNKKGAVLLGVGGDNSFRGVGTFYEGALTAGYPRDDIEDRVQANIVSAEYGTISSSTGPEIEIGSRVSFDSGFGFVSHNGPNVTLLGNLSTGSVSKASTFIVREGNGDKTCFSFESVVEPGHYLRQANYTIFVDSPDSTRDSPSKNKFEEDSTFCTEPALDGSDGVSLRSWNFPTRYLRTHGKHNSLHIAQHGGAEDWDSVKNFYDETSWAIVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBL5</accession>
    <name>A0A1Y1UBL5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_636070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868738.1">
        <property type="nucleotide sequence ID" value="XM_022016863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBL5"/>
    <dbReference type="FunCoup" id="A0A1Y1UBL5">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBL5"/>
    <dbReference type="GeneID" id="33558672"/>
    <dbReference type="InParanoid" id="A0A1Y1UBL5"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="39"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="244"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="501"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="932"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX34475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1100" mass="124223" checksum="B19456D938933555" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBQ8</accession>
    <name>A0A1Y1UBQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_636206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868778.1">
        <property type="nucleotide sequence ID" value="XM_022016878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBQ8"/>
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        <property type="interactions" value="285"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y1UBQ8"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="601"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="638" mass="71216" checksum="87A156F510B80E36" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCY2</accession>
    <name>A0A1Y1UCY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_652509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869566.1">
        <property type="nucleotide sequence ID" value="XM_022018508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCY2"/>
    <dbReference type="FunCoup" id="A0A1Y1UCY2">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCY2"/>
    <dbReference type="GeneID" id="33560317"/>
    <dbReference type="InParanoid" id="A0A1Y1UCY2"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
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        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="198" mass="22498" checksum="48E1B59F27F897D4" modified="2017-08-30" version="1">MSWQSKILRTANAPRTPPTDIEQQIAQALLDLEQNVPDLKTELRQLQISAAKEVDVKGGKKAVVVFVPVPMVKAFHKVQQRLTRELEKKLSDKYIVFVSQRRVLPKPKRNSSTAHKQKRPRSRTLTAVHETILDDLVWPSEITGKRTRVAADGSKLTKVFLDAKEQNLLEYKLDTFSSVYRALAGKDVHFEFPVNASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD80</accession>
    <name>A0A1Y1UD80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_512256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870068.1">
        <property type="nucleotide sequence ID" value="XM_022012965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD80"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD80"/>
    <dbReference type="GeneID" id="33554773"/>
    <dbReference type="InParanoid" id="A0A1Y1UD80"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="264" mass="28288" checksum="D6290973243506AD" modified="2017-08-30" version="1">MDKATYLRSALASKKPSVGFWLTFAKGPVAATILEGGGFDWVLIDAEHGQITDADYFELNNIVASRGASPIIRVPNAEEYLIKRALDSGAHGVMTPMCHSAEDAKKIVAWNKYPPKGTRGFGPMFSAHSFHGMTQATYPAGADSHLLVIVQIESKQGLANVEEIAKVDGIDILFIGPYDLSKFLGVEFGGKEHEAAIAKILKAAKDAGKYAAIFCSSGAQSKMRLEQGFDMVSICTDVGAIAAEFDRQLAATHGVEMGKGRSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD89</accession>
    <name>A0A1Y1UD89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_582047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869684.1">
        <property type="nucleotide sequence ID" value="XM_022013541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD89"/>
    <dbReference type="FunCoup" id="A0A1Y1UD89">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="GeneID" id="33555349"/>
    <dbReference type="InParanoid" id="A0A1Y1UD89"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="809" mass="89521" checksum="71FAAC784DC8F44B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDB0</accession>
    <name>A0A1Y1UDB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_517395</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870131.1">
        <property type="nucleotide sequence ID" value="XM_022012978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDB0"/>
    <dbReference type="FunCoup" id="A0A1Y1UDB0">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDB0"/>
    <dbReference type="GeneID" id="33554786"/>
    <dbReference type="InParanoid" id="A0A1Y1UDB0"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="14">
        <location>
            <begin position="90"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="15">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="480"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="527" mass="57761" checksum="2D13956C2F37434D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDF2</accession>
    <name>A0A1Y1UDF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_521844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870199.1">
        <property type="nucleotide sequence ID" value="XM_022012990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDF2"/>
    <dbReference type="GeneID" id="33554798"/>
    <dbReference type="InParanoid" id="A0A1Y1UDF2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="195" mass="20611" checksum="77F4AB9A3DB53FA4" modified="2017-08-30" version="1">MTSATATTPLGKTRDDSSTPNVTPASGLPDAAAGSKTRDASSEASTSVPPHPSETEKSKVTNDAEGEGDADEEDEISFAEVRKHFFVVRYGLMIAFSHSLLLAHDPRCVIAPISSRSCLRNLDQMTITSLLFGHRDRQLIIPCPGAPTDPLPARFILRTCRGAWTSVGVDDTMLSGDSASSGGSPTGSKDIGRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDQ3</accession>
    <name>A0A1Y1UDQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_630452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870299.1">
        <property type="nucleotide sequence ID" value="XM_022016332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDQ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDQ3"/>
    <dbReference type="GeneID" id="33558141"/>
    <dbReference type="InParanoid" id="A0A1Y1UDQ3"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="502" mass="55322" checksum="68BE77D69DA22E92" modified="2017-08-30" version="1">MDITLLPPTAILSNHSHLAVLPSAFPRRIRGQVTPSGHPHLSSAYRPRRRSFPCPPPPMDGRCMVDELPDEILVNILCFLDWDQVLHLRSVSRRWSNLALSPTLHQSLTLLALPPTPLPYILRIMLQNIRHLHLHLFPYPTSIPGATHPTTALLTLLDAIPPDQLISLSLPFSAPYLPGSDLGKVLKRIGGRLEHLDLRGSGLVGSKWTQWIKWVGKNGHGLRSLDLSFTSISTLPGCPTPTSPLRPFRNPRTLHTALPLTLPVGITDEDILDIDPFRNLRVLSLSSCAYLSEQVLSAFLARLPPLLQRLDVSRLESITFEALWNLRVVNNAEAHDPWLASSASPTSLIDIKVVGIDHLTRLDIRRLKHHWEAQRHVCVPPAPAPATIPQVAWKVPKTPPMKARPLSPPPTPSPPDNSRRMSLMDAALGGALDAKHVPPYGLPTPPDSGSSSDEMDIDDIDPIAQLTHINIVHSAILESEDVDGYRRFIGEVAGGVVRPSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE10</accession>
    <name>A0A1Y1UE10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_631495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869910.1">
        <property type="nucleotide sequence ID" value="XM_022016438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE10"/>
    <dbReference type="FunCoup" id="A0A1Y1UE10">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE10"/>
    <dbReference type="GeneID" id="33558247"/>
    <dbReference type="InParanoid" id="A0A1Y1UE10"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="338" mass="36807" checksum="C7A597F255E61DD0" modified="2017-08-30" version="1">MQALVVTAKGKLELKEVEKPVISDGEILVQVEYVALNPTDWKHRDSVSPAGVILGCDFCGTIVESKSSRPKGQRVAGWVHGGKFPDQGSFAQYIRVAGDRVFTATDLKPESAATFGIGYFTAAMALFNDQKLPYPPAAQEGWFFVGGGSSSVGLFVTQLARIVGYKVIATASPHSFDIVKAHGANRVVDYHDPKSALDEIKKVTDDGIVAGLECIGDLDGVQLAVDSFGPKGGPLTQIIPPPKEVRPRPEVPLDHRILLYTAQGYEFEFIPGQPKMPAKPEDLKWFTDFCERSPEFIEKHDIKGNPVDLRQGLENINQGLDEMKAGKVSGKKLVYKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEE0</accession>
    <name>A0A1Y1UEE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_629347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870003.1">
        <property type="nucleotide sequence ID" value="XM_022016199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEE0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEE0"/>
    <dbReference type="GeneID" id="33558008"/>
    <dbReference type="InParanoid" id="A0A1Y1UEE0"/>
    <dbReference type="OrthoDB" id="2565225at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="489" mass="54365" checksum="638F8F4055DAA70C" modified="2017-08-30" version="1">MAAVGLSTFGTSPESDSYLARAAMSTTMSSHSTDQSSISEAQPTRATMARLASASSHQLFHSSSHRPDSMASDQTDHIVDALASLPWAEPPTKSSPTLSAARTPTYSFLSSDPSQPRATQSRHDSRASTASSRRMRREEDFPMSPSVMTHDFHEIQVARLSNCSGMADVSIRGSTYSAAPSPYARTFGITPEVTPHSGSRSARSSMIRALSRRSVRSKSTKSSKSKRGSSSTLGHRFGDKRWEWAKNDNSVEVEETMDLLSLVGRATVLERMLKRGKRVSTATQHSLRIPSRVSSRASSRPRTRTPQSSRSLRMRLSRRLRRQSSQEDIFTELASDDEEEEEMDDPTLFPPEAQRRRFSLPPSSYHRFMRGVQVSENIVVFPQERPPPVPEKDVFNCTRVICVDPMSPLWIPVDLGEAEKGEGVADRSQSPHLGHRSPHWRNRQSVISYMSMGQWDQLATRRWWIAVGSGVALILVLIVGLLAGLLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEK0</accession>
    <name>A0A1Y1UEK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870574.1">
        <property type="nucleotide sequence ID" value="XM_022016162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEK0"/>
    <dbReference type="GeneID" id="33557971"/>
    <dbReference type="InParanoid" id="A0A1Y1UEK0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="89" mass="9293" checksum="367432FF82BEFF07" modified="2017-08-30" version="1">MTLNANARQSPGPAIRHQTPLKVPGGWSDMPPPPRLQGFDTLSQAHEADFGTRPEGGVEEHAGSQAGPGGSGWFKWITDAGGNTMSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF17</accession>
    <name>A0A1Y1UF17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_626666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870719.1">
        <property type="nucleotide sequence ID" value="XM_022015920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF17"/>
    <dbReference type="FunCoup" id="A0A1Y1UF17">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF17"/>
    <dbReference type="GeneID" id="33557729"/>
    <dbReference type="InParanoid" id="A0A1Y1UF17"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="265"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="454"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="838"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX36650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="101614" checksum="695F942E87B471AB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF58</accession>
    <name>A0A1Y1UF58_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_458933</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870717.1">
        <property type="nucleotide sequence ID" value="XM_022012839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF58"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF58"/>
    <dbReference type="GeneID" id="33554647"/>
    <dbReference type="InParanoid" id="A0A1Y1UF58"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="265" mass="28368" checksum="C114CA143B197CAE" modified="2017-08-30" version="1">MGELNTGMIQSSFPQGIFSDDAEHDVTVTASFPESNPFGLIVNGEQTGLFIHLDNTGSKNYTLVSAAASFHNVENNWALIKNASTLRYNVNLLSGSNLTAPYQVFSEFRPQEMGLTVWVNLVDASTKEVSRVTAMNQTISVVEQPASWADPQLLLLFVILGAALLGGAYAAYSSFFDAGSKKSKGTKKRTTVVTAKESAVPGQPAAKSFEEDWIPAHHLKAKSKPRRRDGGNTSGGEDLTSGGEVTSGAESGPEGKVRRRKAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFV7</accession>
    <name>A0A1Y1UFV7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_627651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870977.1">
        <property type="nucleotide sequence ID" value="XM_022016022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFV7"/>
    <dbReference type="FunCoup" id="A0A1Y1UFV7">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UFV7"/>
    <dbReference type="GeneID" id="33557831"/>
    <dbReference type="InParanoid" id="A0A1Y1UFV7"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="309"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="691"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX36908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="850" mass="94048" checksum="F622621BB0766DED" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UG44</accession>
    <name>A0A1Y1UG44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral to membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_520307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870174.1">
        <property type="nucleotide sequence ID" value="XM_022012986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UG44"/>
    <dbReference type="STRING" id="4999.A0A1Y1UG44"/>
    <dbReference type="GeneID" id="33554794"/>
    <dbReference type="InParanoid" id="A0A1Y1UG44"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012892158" evidence="7">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="334" mass="36959" checksum="EDBAFC5862CD2BA0" modified="2017-08-30" version="1">MRHSVILFLAAGLAVTLAQQQDCPSDPYVDPSQDTCNPLRYVPSIPLNAVAAALYFTVAIILTFLNYKWRANYMLCLVIGAYCEGLGLALRLALRNNLHSSGLYIVMYLFVVLSPCAFLAGDYILLGRLVQHLDGTQYLRPFKARLISRIFIISDVITFLIQAAGGGLSTANKPSVAETGGHIFLAGIAAQMGSFILFSFIWAMFAFRVRFQDQDLWQRKGWKSLHWALGFTCICFMIRSVFRTVELSEGYIGYLATHERFFLGLDTLPLFLGISTYVFFWPGKYITPETRINPGPSDPAISHGESGHSDHVTPHTTTETLAAPPMGEKASALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGM7</accession>
    <name>A0A1Y1UGM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mus7/MMS22 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871259.1">
        <property type="nucleotide sequence ID" value="XM_022018212.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UGM7"/>
    <dbReference type="GeneID" id="33560021"/>
    <dbReference type="InParanoid" id="A0A1Y1UGM7"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1828" mass="204779" checksum="DB9F46F9BD1D7B04" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGQ6</accession>
    <name>A0A1Y1UGQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_642115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871187.1">
        <property type="nucleotide sequence ID" value="XM_022017467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGQ6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGQ6"/>
    <dbReference type="GeneID" id="33559276"/>
    <dbReference type="InParanoid" id="A0A1Y1UGQ6"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="227" mass="24981" checksum="86EC312D189768B0" modified="2017-08-30" version="1">MSTPGLSFKLEIALHTILCIRQVYPPNTFTRRRAHGVPVYQSRHPQVCSYISEVVAAIGKEMEVGRVRRVTVVVKQVSTGLPMERFIIDLGYLGLDKIKERHQREAPLLGAPLAEDLSLMLRGFLIRLVALDSQLEDNRGETTFGIILETDDDLEPSGNKTADGSAAPWVPALASDTLQPASRSVAPVHHEPLLNVKAVETGVIDIRLMVQECIAKTGLDELRVDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGZ0</accession>
    <name>A0A1Y1UGZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_627099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870835.1">
        <property type="nucleotide sequence ID" value="XM_022015964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGZ0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGZ0"/>
    <dbReference type="GeneID" id="33557773"/>
    <dbReference type="InParanoid" id="A0A1Y1UGZ0"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="425" mass="46761" checksum="E1DC16C8F180D534" modified="2017-08-30" version="1">MAPLTIFLTTWNTGLQGSKAQEQDLTSWLLPVLHRTANDPELPKGAVPDIYAIAVQELLPVHLALAGLSGTVLLALTDRIVSLLSAHAKSLSGSQETYRLVSRVAHGGNALWVFARESTTRGRIGKPLTSTLGLYWFGLSNKGAVGVRVPVQRSDKGQWENLTFVCAHLEAFDHNVPRRNSQYRHILTSLVFQGSDPLVKPAQVFETSHLFVMGDLNYRLTHLPGGAYPDEEGEGVQAEKERAKLVEVDTLKREQKMGRAFGGLREGDLTKFIPTYKRIVGKVNGFSRKRIPGYTDRILFASHDDTPSSSSTVIKHFGSTPQTTLSDHKPVHAVLELPEPSHSAASPHLAPILSQPPPPHPHWPLATPHEQRIVQKIIGQILDKLIGWPWCILVLLGFGNTRAGMGVGAFAAMIWGVWWSGSWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHA7</accession>
    <name>A0A1Y1UHA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_651034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871478.1">
        <property type="nucleotide sequence ID" value="XM_022018253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHA7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHA7"/>
    <dbReference type="GeneID" id="33560062"/>
    <dbReference type="InParanoid" id="A0A1Y1UHA7"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX37440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="346" mass="38805" checksum="CD71430492742CBF" modified="2017-08-30" version="1">MSLPSDRLQKDDKVLIIGVTGLVGASTADALAQRGLKVVGATRQVGPRTQPLKDKLDGLYGKDTIEFVQIKDYTDVNEYRAILHGVAGIVYQAYDLSTLDTTKAVETAYKTTWAILEAAYETPSVKSIVFTSSTAAIYNATYGQDMDLSLDDYNDTGYEKAFRLPDDAPEKFGFVYSATKVKMEKTLWDFVKQHKPSFAVNTVLPHMVLGKPFNPAEGVYSTSTWTKWIFEGKLDNNPGVGFWLPSEWHIDVRDVAIIHVAALLDPEVNGQRMWAAVAPPVHINELLAQWREQYPERQFVQDFDVPSPPKQNILDNSLGQKLLEKWAGRDLISFEEMIHETIEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHE4</accession>
    <name>A0A1Y1UHE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_448539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871447.1">
        <property type="nucleotide sequence ID" value="XM_022012808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHE4"/>
    <dbReference type="GeneID" id="33554616"/>
    <dbReference type="InParanoid" id="A0A1Y1UHE4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="367" mass="40016" checksum="06AB216747C7A71F" modified="2017-08-30" version="1">MIKRGVDGMSPIQGPEHLPPSRDEETSSPPFKRATLERADSITATTEMVESSPSITSWDWVSSASSPHLSSVDDNDWRGIMSQVGPGVQPLHDIISAMRTTERGEQDEASKGDSGCTLSDSKLITRPVDEPRSRGSPTTSIIDVEQFPSTELPNPNAILHSSMQALQAQLATVQSRLAALIPFAQPDPDETAVLSSDPLPVLTARNRILERNLQAANDKNASLERTNANLTRALNTQRNIVKKKEHELAELRPFVPPPDVMPGNGIDPAVISELANDLISGVKTVDEIASSLLDLVETAGGTLIEKERQDLHPVVRLNNLEGVLDVTLGRVAALEKDTKRLVRREDEAIYQRCEAADTSEPVMSDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHM2</accession>
    <name>A0A1Y1UHM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_422242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871065.1">
        <property type="nucleotide sequence ID" value="XM_022012734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHM2"/>
    <dbReference type="GeneID" id="33554542"/>
    <dbReference type="InParanoid" id="A0A1Y1UHM2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="154" mass="16494" checksum="C6E08874B352741E" modified="2017-08-30" version="1">MFLLPLRRLCPYSLPHPDSTSNHPSLSGRSGQSVTFWSSPLLPPLTLNGLTLSRRLVFDSSTLLSSFLSTIDSSVKGNQAFILPSAKAKTSAPPLSWCGAVSTRTEAPRFSPPVSASRSVGSRPPDHRRLSRWGMGKKAAEVCGSGSRRSACVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHR5</accession>
    <name>A0A1Y1UHR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_624691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871115.1">
        <property type="nucleotide sequence ID" value="XM_022015726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHR5"/>
    <dbReference type="FunCoup" id="A0A1Y1UHR5">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UHR5"/>
    <dbReference type="GeneID" id="33557535"/>
    <dbReference type="InParanoid" id="A0A1Y1UHR5"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="420" mass="45898" checksum="17F989473571049D" modified="2017-08-30" version="1">MTAAPDPHHIIRTHHAPIAALRFDPTNAKLYAGDQDGFISIIDLKARRPLSHWKAHEGGVLGVNEVNACLISQGRDNKLHLYDTHVGNLFTSGPGPSHPPPSIAASLDINALNFCRFSMCSIPRSSLRMSSAKKGKGKAFDDDVAVLALPNLVDSELADIYLLPSMSRLHAAFNMPPQHADKSIKPAKTIIPASTRSGLIMAIHIAYNEAEKLRVVLAYEDGRVEMWKLADDEKDWRQASDARLNEADDRAWIKVREFKGHNEAVMAMTVNSTLSRAYTVSADHQLCRYDLSAESEDGCIKKQNTGQIGNASIAISADDKVVAVGGWDGKIRLFSAASLKPLGTLAFHRETVHTLAFANCVPVTNDTIAPGDTASTLDLEAEDSDEEEETREQLLRGRYLASGGKDTRIALWLLKDFAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHV0</accession>
    <name>A0A1Y1UHV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_650204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871627.1">
        <property type="nucleotide sequence ID" value="XM_022018115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHV0"/>
    <dbReference type="GeneID" id="33559924"/>
    <dbReference type="InParanoid" id="A0A1Y1UHV0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="182" mass="19766" checksum="799AFA646B1FC4A9" modified="2017-08-30" version="1">MSELAGSSINATNDGSLAMQLLTAKDDPIARATETQRRELLETLIFSKPIRCTSSGLDSGRWTVSCTFPEQGTLSGADATELDPFKKELQDTSVSPRLNGNLSVRARKQDDAVHIESSADQGLFDTEIFWKLRVDPTGPHDSLDETIEESILGSEWSALSSNIETKIEGKGISMDDSNSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UID9</accession>
    <name>A0A1Y1UID9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase 1 alpha subcomplex assembly factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_623416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871798.1">
        <property type="nucleotide sequence ID" value="XM_022015579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UID9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UID9"/>
    <dbReference type="GeneID" id="33557388"/>
    <dbReference type="InParanoid" id="A0A1Y1UID9"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="243" mass="26105" checksum="B1E1D1C79EA132CB" modified="2017-08-30" version="1">MSSSRLCEAIASSSRTLVHAARLPRHRPGSISLISRSRISVRSLSPSQHASSSARFFSSSRSSLSDPQPSRYSKFDTSMKSDVRDSSIDPNSPTVLSNIVNADEGLLTITKFSEHGIQFNDGTVTRSGVLVLGGQVFGWDVQAPVVKSGQRSGGGGGVEGLWKEWTEDRFALLELVTPKPEILLFGTGSRPLPVPQRMKDSMSKLGISLDVMDSRNAASTFNLLQEEGRQVGLALCPLVSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIH6</accession>
    <name>A0A1Y1UIH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_579488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871332.1">
        <property type="nucleotide sequence ID" value="XM_022013381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIH6"/>
    <dbReference type="STRING" id="4999.A0A1Y1UIH6"/>
    <dbReference type="GeneID" id="33555189"/>
    <dbReference type="InParanoid" id="A0A1Y1UIH6"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="414" mass="46388" checksum="D6AAE48F80C65524" modified="2017-08-30" version="1" fragment="single">MVKVTNTQDDNALQFDPCSETHARDWSYRAEGGAHFIFGYDGSAKGYVDRVLRIQKAVAASGPDETMRRVWVMDLLPKLLPRDLLLQSVLVELQEKWLKELMSTDMSKRPEERKGSMAGTASLTDSISGSTHGWIMDDLIARGKKEESVLCVEIKPKWGFLPDQQHVQPPEAAGIKSQIPRFHLHEHFRGNYTSEDVGYNPLDLFSGQQARMKKALEGLWLGWEASEGRKNNWRVYVDGQVVLPASVIKPIDVPTTGSKQSVRDSTIDLVLPCLISSNVFGLVGRLQSRLDATDISDLATRYGAEYPDAEPFAGSASSEATEAELRTLVARFVAASANPQPQSWSLRESLIAYSLAAIFKDCSIFVRIPLARKDGSWQVSANPSVKVVDVDLKPLCSMRKWYDLDEKLWKHWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJB2</accession>
    <name>A0A1Y1UJB2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_624352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872046.1">
        <property type="nucleotide sequence ID" value="XM_022015689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJB2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJB2"/>
    <dbReference type="GeneID" id="33557498"/>
    <dbReference type="InParanoid" id="A0A1Y1UJB2"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="164" mass="18038" checksum="1E3E6D797C42C38F" modified="2017-08-30" version="1">MSVTLHTNLGDIKIEIFCEAVPRTAENFLALAASGYYDGTLFHRNIKTFMIQGGDPNGTGKGGQSIWGKPFPDEIRQTLRFNARGIVAMANAGPDTNKSQFFITYAKQSSLDGKYTIFGRVIDGADSTLDMMEKVPVNEKNRPLEEIKLTNVTIHANPIAQAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJT4</accession>
    <name>A0A1Y1UJT4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_608252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871751.1">
        <property type="nucleotide sequence ID" value="XM_022014108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJT4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJT4"/>
    <dbReference type="GeneID" id="33555916"/>
    <dbReference type="InParanoid" id="A0A1Y1UJT4"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="223"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX37764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="327" mass="35589" checksum="58B02E498C1DF6A3" modified="2017-08-30" version="1">MAQSSIPSASKDGSSSKKAIPLSTHLIAGGIAGLAEALACHPLDTIKVRMQLSRSRKLAGLKPLGFFATGRQIAIRETPLGLYKGLGAVISGIVPKMAIRFASFEMYKGWLKKPDGTINPKATFLAGLGAGATEAVAVVTPMEVIKIRLQAQQHSLADPMDIPRYRNAGHAAFTIIREEGIMTLYRGVSLTALRQATNQGVNFTAYQQFKKLALEYQPQQKDLPSYQTMLIGLISGAMGPFSNAPIDTIKTRIQKASHKPGETAMSRLINVTTDLFRNEGPRAFYKGITPRVLRVAPGQAIVFTVYERVKATIDRIKDTGYRPTFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UK64</accession>
    <name>A0A1Y1UK64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_620604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872294.1">
        <property type="nucleotide sequence ID" value="XM_022015304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UK64"/>
    <dbReference type="STRING" id="4999.A0A1Y1UK64"/>
    <dbReference type="GeneID" id="33557112"/>
    <dbReference type="InParanoid" id="A0A1Y1UK64"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="906"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="774"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="937"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1032" mass="109170" checksum="DE2913C1A5BA6D42" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKA5</accession>
    <name>A0A1Y1UKA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871542.1">
        <property type="nucleotide sequence ID" value="XM_022018103.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKA5"/>
    <dbReference type="GeneID" id="33559912"/>
    <dbReference type="InParanoid" id="A0A1Y1UKA5"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="823"/>
        </location>
    </feature>
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        <location>
            <begin position="1206"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1322"/>
        </location>
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        <location>
            <begin position="909"/>
            <end position="957"/>
        </location>
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        <location>
            <begin position="1058"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
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            <begin position="182"/>
            <end position="191"/>
        </location>
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        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="295"/>
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        <location>
            <begin position="319"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="680"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="816"/>
        </location>
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        <location>
            <begin position="1212"/>
            <end position="1225"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1322" mass="140716" checksum="706D8D9BBB359F2C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKF1</accession>
    <name>A0A1Y1UKF1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_656176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_022018837.1"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="196" mass="21833" checksum="1CCBD526366D762F" modified="2017-08-30" version="1">MSSLLPQYHTKASDSDINDEERQPLTSWKDNDRSSSPPPPSYPPQASGSQAHRPNVTYVFVPRWPVKGEQKSVLGVAAGKDDTIDLVRRAFPVLAEYSPDRIEFLAPSTPETQIDNITQWSQILDEAWHGIETNPPARLKVQVIDGPGDLEERTRRKEREDKIVVLAFFCLPALGLLLFLIIMSATGNLNSEKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKM7</accession>
    <name>A0A1Y1UKM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_621529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872523.1">
        <property type="nucleotide sequence ID" value="XM_022015391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKM7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKM7"/>
    <dbReference type="GeneID" id="33557200"/>
    <dbReference type="InParanoid" id="A0A1Y1UKM7"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666038" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="391"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1010" mass="110092" checksum="7908D9DF1819C41E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKS2</accession>
    <name>A0A1Y1UKS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_608054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872575.1">
        <property type="nucleotide sequence ID" value="XM_022014097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKS2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKS2"/>
    <dbReference type="GeneID" id="33555905"/>
    <dbReference type="InParanoid" id="A0A1Y1UKS2"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="678"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="2">
        <location>
            <begin position="956"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX38653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1193" mass="136589" checksum="3E72B67A683CA6E8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKU5</accession>
    <name>A0A1Y1UKU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1748-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_621572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872531.1">
        <property type="nucleotide sequence ID" value="XM_022015396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKU5"/>
    <dbReference type="GeneID" id="33557205"/>
    <dbReference type="InParanoid" id="A0A1Y1UKU5"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX38609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="8879" checksum="3F5E371883F73ADB" modified="2017-08-30" version="1">MVLGRLMHYTFDALAISAVIAGVKKSTGFGPATDKIPDSSFKSIADSYFSAGEVIFNLAAGQAVTSDYFKKIERSSSFFSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKV3</accession>
    <name>A0A1Y1UKV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_621923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872605.1">
        <property type="nucleotide sequence ID" value="XM_022015423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKV3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKV3"/>
    <dbReference type="GeneID" id="33557232"/>
    <dbReference type="InParanoid" id="A0A1Y1UKV3"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX38683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="354" mass="38459" checksum="5DD9048735AD943F" modified="2017-08-30" version="1">MAEHSTLEAILGGTQVPHQPLLIITDSAVFSGLAVFKESLRRALRMRGPVVLVTALHKPSLLQQQPSPEFDSANLTTVDLTGEVPGLTLDESGPSFSKRILEASKPESQIFIDAIGVLAEDYSPLEAIRLISSILTQAKSPGRLTLLLPYASTILQTLIHPSFSPTLSLLTILNPRVVEFLSKSYLQPVSSSPPFWMILERAKERRTPEQLAYNGEEGVEVGDWTRSKSGAVVQVLVRKATGGIKGISRTLASISAQNHTSNSSSREELVAGPVDSVVDIKPFAAPTSASSLGRSARVDRPAQTPTEMNLPFNLSLTDEQRRRRGQVPLPYAHEGEGADLMEYGDDEDEDDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULJ8</accession>
    <name>A0A1Y1ULJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_617592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872722.1">
        <property type="nucleotide sequence ID" value="XM_022014936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULJ8"/>
    <dbReference type="FunCoup" id="A0A1Y1ULJ8">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULJ8"/>
    <dbReference type="GeneID" id="33556744"/>
    <dbReference type="InParanoid" id="A0A1Y1ULJ8"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="86" mass="9777" checksum="B06924AA489F5001" modified="2017-08-30" version="1">MDFSQFNGAEQAHMTKVIERKQMADFMKLYSGMVERCFNACAQDFTSKALTSNETTCVQNCTDKFLKHSERVGTRFAEHNAEQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULT0</accession>
    <name>A0A1Y1ULT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872072.1">
        <property type="nucleotide sequence ID" value="XM_022015703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULT0"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULT0"/>
    <dbReference type="GeneID" id="33557512"/>
    <dbReference type="InParanoid" id="A0A1Y1ULT0"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="34886" checksum="430CA09414D34143" modified="2017-08-30" version="1" fragment="single">MGRRSEQAKKRKRLLGSSMSGSIKYAKHPPTQNTDTASTEIEPLVSAQDLETTISTLETLCEFPDELSRKDVKGVKRAVHALNRVMVDGAPIGTSLSSKISSALQAYRFIDALVLLFEMYIRDLPPKLGSLQRWVRECDATFSVDGLVRDTDAMRCLDLILRIADREMVSGSSQGAGDLVMRRRPVWRARDPVAEELPIWGILQQGRLFDTPPPVPFPNFRPVQHTPGHLRKPPNVYDSTVYASSPGAIRLSTSRPRSPSRVDVPGLPGAFVILDVFTPEECLQIVQAGEAIGFERDEAAGGSAASKSSASVPSGIRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UML7</accession>
    <name>A0A1Y1UML7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873164.1">
        <property type="nucleotide sequence ID" value="XM_022015140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UML7"/>
    <dbReference type="GeneID" id="33556948"/>
    <dbReference type="InParanoid" id="A0A1Y1UML7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="170" mass="18510" checksum="D4BEF540697EE5B0" modified="2017-08-30" version="1">MLSGIDELFDAVSDPPRSGHDAFPRHQIHWTFGNADEVDDDVPIGSSSRSLNVLPSSSTPSRQRQPSFRRPTLPSCAGKKSPARIINSPNQRDRNPLDLSFGASPSKAEIEQRSGVIPARPKRASKSAEQTLSKCELAVLALCQAKEIQMFTMNGGFSVFGQRKDGFASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMN0</accession>
    <name>A0A1Y1UMN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_679783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873171.1">
        <property type="nucleotide sequence ID" value="XM_022019053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMN0"/>
    <dbReference type="GeneID" id="33560862"/>
    <dbReference type="InParanoid" id="A0A1Y1UMN0"/>
    <dbReference type="OrthoDB" id="2586408at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59135" checksum="157502DD6CE92FFA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMQ8</accession>
    <name>A0A1Y1UMQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_619194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873162.1">
        <property type="nucleotide sequence ID" value="XM_022015138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMQ8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMQ8"/>
    <dbReference type="GeneID" id="33556946"/>
    <dbReference type="InParanoid" id="A0A1Y1UMQ8"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20421" checksum="921FA5215031B5B2" modified="2017-08-30" version="1">MAFEDFDFDSSSRKSAITMGWNPFGGSSEAGPSNTGSSSSAATTAPDPPRPLDWDTVYRDELRNQEAQIPTVDDVPTCMSLFDSFFKCYALFPAVRGYYRYGYVRSCSHKWDDYKYCLSIKSEDAEERRRLWIKRVAEGWTKRRLEGSSEDVWEARRTPPENFPPPWPEDLGNEQVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMT6</accession>
    <name>A0A1Y1UMT6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_620895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872367.1">
        <property type="nucleotide sequence ID" value="XM_022015334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMT6"/>
    <dbReference type="FunCoup" id="A0A1Y1UMT6">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMT6"/>
    <dbReference type="GeneID" id="33557143"/>
    <dbReference type="InParanoid" id="A0A1Y1UMT6"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000028">
        <property type="entry name" value="Replication factor C subunit 2/4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="60"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="349" mass="38730" checksum="3BEFFD36F46293BF" modified="2017-08-30" version="1">MSTMASSSKGKMPAAPTVKHADAEGYEMPWVEKYRPILLSDIVGNSETVERLKVIAEDGNVPHIILSGMPGIGKTTSIHCLAHALLGDAYKEGVLELNASDERGIDVVRNKIKSFAQRKVTLPAGRHKIIILDEADSMTSGAQQALRRTMEIYSNTTRFALACNMSNKIIEPIQSRCAILRYTKLKDAEVLKRLKEICEMEGVKSSDEGLAALIFTAEGDMRQAINNLQSTWSGFGFVSPENVFKICDQPHPLVVQTMIKHCQKGEIDQALARIDALWDQGYSAVDIVVTVFRVVKGMEELPEYTKLEFIREIGWTHMRILEGVGTLVQLGAMIARLCRMSIPPEMLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN16</accession>
    <name>A0A1Y1UN16_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_297537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872770.1">
        <property type="nucleotide sequence ID" value="XM_022012416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN16"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN16"/>
    <dbReference type="GeneID" id="33554224"/>
    <dbReference type="InParanoid" id="A0A1Y1UN16"/>
    <dbReference type="OrthoDB" id="2589888at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="355" mass="40192" checksum="29B8EB913051079D" modified="2017-08-30" version="1">MSPWDRVKGSAAQPLNELGRLYLLPRDELPSVWLGIFRRHQRLQKEILKGLNAFTQLGTDHRWDDEDDDDDVLDFGDGMVYPTYEEGPGTKEVEPEPNLDAPVSKSERFVEDFDRSWPRRAPLPIASETPTAPPTSTALPQKPAQDAERVLFNANSNRMEAPRRQPPPTQNQPLPPPTKLLSRSSDTGNAPALPRTFDRPLPPHLQGDEMQSTSRDAQATSRRSPWGADAHTPQNPSQTRTSPQAPLSSLPPRKSFSQHPHQQQQTLHPQQQQQQHNNNNNNNNNNNNNSSSSSSSNNNNNSNNTSSHRWVSRRPLTRALRHTQQPQSPIHPCLPWCLSSIRRPRKCMLQLKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN83</accession>
    <name>A0A1Y1UN83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_617870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872779.1">
        <property type="nucleotide sequence ID" value="XM_022014958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN83"/>
    <dbReference type="STRING" id="4999.A0A1Y1UN83"/>
    <dbReference type="GeneID" id="33556766"/>
    <dbReference type="InParanoid" id="A0A1Y1UN83"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012530754" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="329"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="479"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="669"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX38916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123913" checksum="F1AA3A72B6EF5C29" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNK3</accession>
    <name>A0A1Y1UNK3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caspase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_640862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873408.1">
        <property type="nucleotide sequence ID" value="XM_022017377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNK3"/>
    <dbReference type="GeneID" id="33559186"/>
    <dbReference type="InParanoid" id="A0A1Y1UNK3"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="80"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX39623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="375" mass="41328" checksum="410AF4E6E8C639E5" modified="2017-08-30" version="1">MDDRYQYQDQQGYEPYAPPLGPPPPPPQQQHYYGGYQGYDNQGYAPPPGPPPTQREVYQQQDAQGHVAEQSFEYSRCNGKKKALLIGINYFGSDAELGGCINDVYNVHAFICGRFGYDPADCVILTDDKQDPRSYPTKDNIIRAMAWLVDGAQRDDALFFHYSGHGTQVEDVDGDEHDDDDEAICPVDFQQAGLIIDDDSAHDLLVKPLPAGCRLTAIFDSCHSGTVMDLPYAYTVEGNIKKPNLFEGTQSHLLDAGMGVLTGNTGNLFSGLFRAAQEAFENHQSQEMTVKTKTSPADVIQWAGCKDSQTSADTQEAGKATGAMSYAFIASLSKYPDQSYQQLLETVREEMKGKYSQVPQLSACHPIDTSLQFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP21</accession>
    <name>A0A1Y1UP21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_618864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873079.1">
        <property type="nucleotide sequence ID" value="XM_022015089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP21"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP21"/>
    <dbReference type="GeneID" id="33556897"/>
    <dbReference type="InParanoid" id="A0A1Y1UP21"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX39216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="291" mass="32793" checksum="F6FF98F514D0C562" modified="2017-08-30" version="1">MKDLGPAESQWLFTDADLDRTPSRLDGITSEDELRRRKKAIEYVRSIGLRAGLGGREANSPSARGVMAPAAMLVHRFYMRRSLKDFPEELVAPAMLFLASKIAEDSLKLRYIVNACLSKWEPGALPWEPDPNNKDTYPPQSLEYKRWEREILIVEELALEALCFDMAIINHWTIFRRAILNLNGEAVPKWMKVNGLELGWGLFNVIAQTPLVVTTHPHILAFGVFVILLAAMDDMSISSAIKSNSEASSAFTVDLNDETTVEQIKHFCARVRAYSSMDLIDQGLVDLIRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP37</accession>
    <name>A0A1Y1UP37_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873586.1">
        <property type="nucleotide sequence ID" value="XM_022014674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP37"/>
    <dbReference type="FunCoup" id="A0A1Y1UP37">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="GeneID" id="33556482"/>
    <dbReference type="InParanoid" id="A0A1Y1UP37"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="905" mass="100459" checksum="A3307E1E0446C8DE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP62</accession>
    <name>A0A1Y1UP62_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_615072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873594.1">
        <property type="nucleotide sequence ID" value="XM_022014678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP62"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP62"/>
    <dbReference type="GeneID" id="33556486"/>
    <dbReference type="InParanoid" id="A0A1Y1UP62"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX39809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="527" mass="56620" checksum="443F0B61EAAB9986" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPD3</accession>
    <name>A0A1Y1UPD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_615483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873695.1">
        <property type="nucleotide sequence ID" value="XM_022014727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPD3"/>
    <dbReference type="FunCoup" id="A0A1Y1UPD3">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPD3"/>
    <dbReference type="GeneID" id="33556535"/>
    <dbReference type="InParanoid" id="A0A1Y1UPD3"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX39910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="232" mass="26119" checksum="471289907AD8287C" modified="2017-08-30" version="1">MPKSKRSKVTSLTKTPLRTTKESKLALGNELRAQIDTYDHVWLFDLGNIRNDALKELRVQWRGTGRFFFGRGRVMAKALGESVDTEHEPGLSQIAESIKGSMGLFLTSWDVEETREWFDSWSRKEFARMGDNADREVVLPAGPILSPFTDPPSGDPFPHSMEPQLRNLGLSSCLLRGVPSLKEPHVVCREGDVLSSEQCRLLKLLGVQMAEFRVHLGPRWTRGRGFVPSAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ15</accession>
    <name>A0A1Y1UQ15_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_219196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873331.1">
        <property type="nucleotide sequence ID" value="XM_022012209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ15"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ15">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ15"/>
    <dbReference type="GeneID" id="33554017"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ15"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="265" mass="29323" checksum="F2E8FDBEBB33FFB9" modified="2017-08-30" version="1">MPYPVIVVTGDSIAQQSFKAGGYGSALVDFYQGNYDVLNRGMGGYNSTQLLQRFIEGLDVPSSADVRLFVIHIGTNDCAEKGYQRTSASEYRDNLLSIIQHIRTIYPAAEIVLLTPSTVQSDVILALERSTGMPEKFITIRTPERAREIAEMCKAVALEEKVDCLDVFAMHEGQRDIFSDGLHYNAKGYKPVNDALIQLICSKFPKLVPDDLPRAFPIFATYGREGIDSFEQYATAIKEIGQRMKAQALDETGSEGMQSDGSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ36</accession>
    <name>A0A1Y1UQ36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_263320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873955.1">
        <property type="nucleotide sequence ID" value="XM_022012320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ36"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ36"/>
    <dbReference type="GeneID" id="33554128"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ36"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="452"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="666" mass="71279" checksum="6843BF1327F38112" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ62</accession>
    <name>A0A1Y1UQ62_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_678715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873381.1">
        <property type="nucleotide sequence ID" value="XM_022019010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ62"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ62"/>
    <dbReference type="GeneID" id="33560819"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ62"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF1">
        <property type="entry name" value="CIRCUMSPOROZOITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010999193" evidence="2">
        <location>
            <begin position="22"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX39596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="564" mass="55238" checksum="49FA6F651006250F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ88</accession>
    <name>A0A1Y1UQ88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_644621</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873986.1">
        <property type="nucleotide sequence ID" value="XM_022017596.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UQ88">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ88"/>
    <dbReference type="GeneID" id="33559405"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ88"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000583">
        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000946">
        <property type="entry name" value="Probable serine/threonine-protein kinase DDB_G0284251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="11"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="279"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="354"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="575"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1266"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1341"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1266"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1284"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX40201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1389" mass="151944" checksum="26282612DDDF1197" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQA2</accession>
    <name>A0A1Y1UQA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_261928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873937.1">
        <property type="nucleotide sequence ID" value="XM_022012316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQA2"/>
    <dbReference type="FunCoup" id="A0A1Y1UQA2">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQA2"/>
    <dbReference type="GeneID" id="33554124"/>
    <dbReference type="InParanoid" id="A0A1Y1UQA2"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="135"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="342" mass="38092" checksum="BA773097ACBB4AA7" modified="2017-08-30" version="1">MSLAWPLGDLLSTDTLYTCFKYAAGFGLAGSTIAATGLYLYQCKLIYPSYVPEGSRKIVPTPKDVALPYEDVKLTTSDGVKIRAYVIPARRKQISTEDLKMASPSARKEIAEKEVADWTEEMGQDEAIEYAKSRPTIILFHANAGNVGHRVPIARKFNADYKCNVFMLSYRGYGLSEGSASEMGIRKDVDAAFDYIRAHPILGSTKLVAYGQSIGGAVCLYTGYKYSDLLSGIIIENTFLSLPNLVPLVLPQLPKFLLPLLLTEQWDATLSLPHIPPSLPMLFLSGKRDALVPPAQMQELYRIRGDGKKRWKELDGEHNDTYLAKGYWEEVGDWLHEEVETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQC6</accession>
    <name>A0A1Y1UQC6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_644646</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874053.1">
        <property type="nucleotide sequence ID" value="XM_022017598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQC6"/>
    <dbReference type="FunCoup" id="A0A1Y1UQC6">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQC6"/>
    <dbReference type="GeneID" id="33559407"/>
    <dbReference type="InParanoid" id="A0A1Y1UQC6"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="420"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="701"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="900"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX40268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1031" mass="112360" checksum="2E9BA29E47527CFF" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQN2</accession>
    <name>A0A1Y1UQN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_615344</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873662.1">
        <property type="nucleotide sequence ID" value="XM_022014710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQN2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQN2"/>
    <dbReference type="GeneID" id="33556518"/>
    <dbReference type="InParanoid" id="A0A1Y1UQN2"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012756373" description="Tafazzin family protein" evidence="14">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="71"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX39877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="337" mass="37229" checksum="EC5F62DD4FE2D08C" modified="2017-08-30" version="1">MAPTLISGLTLSATALLFRAVARARTTSFNVQGLPILLEALKARDAQLDIKGKGKALYGVGESTDLGTQGILTVCNHNSVVDDPMAWASMPITTYMPFASPSSVSRNSRWTLGARDIMFTNAFLRKFFAWGQVLDTERGGGIFQPAVDEAIKILQSGGWLHIFPEGKVNQRNINPEGGLIRFKWGVSRILMDSKTLPEIIPMWISGFDTVMPEPRSVPKWLPRRGGKVTVTYGQPVTDRIRPLIDEWRRLAGNQQGTVGVGGVWEKQGSSPSGQEQRRTREAGRLADGHERTLRIKICEVLQESVRKLGEAVERGEGRFERGEWCQSVAGINRQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQW8</accession>
    <name>A0A1Y1UQW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mog1p/PsbP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_610756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874129.1">
        <property type="nucleotide sequence ID" value="XM_022014217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQW8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQW8"/>
    <dbReference type="GeneID" id="33556025"/>
    <dbReference type="InParanoid" id="A0A1Y1UQW8"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21437" checksum="FB40936EB3A69871" modified="2017-08-30" version="1">MEVRELFGGAMRMELPGDYIDASDLRQIPDNQEVFLSPSSDTSLVVEVLDWVEEGGARDNLWEAVKFHFESIAHDNDSLASTILTSSSSRPSRPTGPQTPEPITLTGTQRVHKFSHSTGPRPGHESDQPDEVFVGVALWRVWIEGSRKKQADVVCSVNVNMSKDDKKEIESWWLKAVKSLQILDWDLFVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR92</accession>
    <name>A0A1Y1UR92_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inositol phospholipid synthesis and fat-storage-inducing TM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_647427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874178.1">
        <property type="nucleotide sequence ID" value="XM_022017655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR92"/>
    <dbReference type="FunCoup" id="A0A1Y1UR92">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR92"/>
    <dbReference type="GeneID" id="33559464"/>
    <dbReference type="InParanoid" id="A0A1Y1UR92"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="461" mass="49560" checksum="9964F71E6FA1C302" modified="2017-08-30" version="1">MSSSTPSLRPSPRIITTPRSTSPNSPIVPGSNNTAFASSSSTSPNVQSSRHKSRGSFASPVEVLSRSPNARRMSRSVYSQSGTMLPDGPMNVKRLWDHPIILAGTLLTTVMLCGIVYSLIFHTSLDTSLPSSFLTRDRPGAPYLARKSNILNRLFVKYCWGWTSLAFISHLISSPPSASSSRFTRLIAFGAGTATWLVFTTWFFGAGLGDRVIALSGGHCAITVPSEWGVNPDTLRHLWSDITDSVPTSSSSSSSSLLGSDGGPFLLPLPSSFCSSKLALTPSTHPTLFKALKGSMDSTLLSRTRIPQPRWHKGFDISGHAFLLTLATLLLVRELAPSWRSLLRTRRTIHTTITPLSIGRGGSVHLASISFGTALTTLWTVMLGTTAVYFHNPQEKLSGLALGLGFSALIHALTPESSSLLSSLPQTIGTIHEDENSARRGKIVDDGEVVNQDVVKALEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URA3</accession>
    <name>A0A1Y1URA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873799.1">
        <property type="nucleotide sequence ID" value="XM_022017866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URA3"/>
    <dbReference type="GeneID" id="33559675"/>
    <dbReference type="InParanoid" id="A0A1Y1URA3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="166" mass="18070" checksum="9B0DABDC6F976520" modified="2017-08-30" version="1">MAYWYMTTSRRSWESSATASAPGVDTGETALPSAESHNSLPERWALLFKQETRDAFNVGDEETKSKVSKTRHEIQATYSSLTDGKKSGILTGEDRLLLATLAAKETLASFLGRSLKPKEFESNAGQLEAIVTRIHEAKVRSDSMKSAGSLSQSTPSLGEDKSEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URD5</accession>
    <name>A0A1Y1URD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">BD324DRAFT_250173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URD5"/>
    <dbReference type="FunCoup" id="A0A1Y1URD5">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URD5"/>
    <dbReference type="InParanoid" id="A0A1Y1URD5"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="361"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="632" mass="70824" checksum="29970F0046C2021B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URF7</accession>
    <name>A0A1Y1URF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD324DRAFT_648675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873849.1">
        <property type="nucleotide sequence ID" value="XM_022017872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URF7"/>
    <dbReference type="FunCoup" id="A0A1Y1URF7">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URF7"/>
    <dbReference type="GeneID" id="33559681"/>
    <dbReference type="InParanoid" id="A0A1Y1URF7"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="426"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="13">
        <location>
            <begin position="597"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ORX40064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="748" mass="82374" checksum="6778891274FDF902" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URS0</accession>
    <name>A0A1Y1URS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_648804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873989.1">
        <property type="nucleotide sequence ID" value="XM_022017889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URS0"/>
    <dbReference type="STRING" id="4999.A0A1Y1URS0"/>
    <dbReference type="GeneID" id="33559698"/>
    <dbReference type="InParanoid" id="A0A1Y1URS0"/>
    <dbReference type="OrthoDB" id="2579977at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012666042" evidence="1">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="44"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="319" mass="34794" checksum="4CB8A110645EE78A" modified="2017-08-30" version="1">MLGSYLVTWLLLQCLALGAVIPSPLSGTQYGVVDKSCPCGYVLTEYGNAYYPYYKLVTFDSLPVGPLKSANGLESLGFDISDEIYIGGTGPGNTTSVGHYYNIHIAKQSKAKDASHIMQLIVPGGQRAPGNLSGAEIHSSQAFTGGVFTAEMQMSGIVGTDQSMFTYHAADNSDDGPQDEQDIEILAAYLFKAGKNGTPPGVELTNWDPTDPENEKHSDTIVPFPQDPTKSFHNYTIAWLNQTTQYYFDKTLLKSPKGYYSYHPSYLYLNNWSDADPEFTLGPPKKTVIQQVKSISMYYHTAAQPGILAGCSMNQACLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URU2</accession>
    <name>A0A1Y1URU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_648758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873941.1">
        <property type="nucleotide sequence ID" value="XM_022017878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URU2"/>
    <dbReference type="FunCoup" id="A0A1Y1URU2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URU2"/>
    <dbReference type="GeneID" id="33559687"/>
    <dbReference type="InParanoid" id="A0A1Y1URU2"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="202"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="685"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="843"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="933"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117843" checksum="E1BFD79B10B483BA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URY5</accession>
    <name>A0A1Y1URY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_647709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022017701.1"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A1Y1URY5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012237356" evidence="2">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="150" mass="16703" checksum="5D80141759CE654B" modified="2017-08-30" version="1">MLLVLPSLLTVLFIFPVAQRVSLFKLDIGSTEHSIGAQGYKVRGGQWTSSRFAYPAPDDWPKEIDDLPIWLLFHLILGILIGVYFLILCLTFAFEKGSHKTMAILEPFWWSRVPALLLAALSVALASRDAAFWGQAAKVSRFRADALGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US09</accession>
    <name>A0A1Y1US09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874438.1">
        <property type="nucleotide sequence ID" value="XM_022012138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US09"/>
    <dbReference type="GeneID" id="33553946"/>
    <dbReference type="InParanoid" id="A0A1Y1US09"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="190" mass="21195" checksum="1CDAC6E1B7AE5268" modified="2017-08-30" version="1">MSRHVHVALNPFIDPQPLQLPNCHCGKAAGSSGYCGEHTCSVGGCTNASTSSWGKCSYRGFNDSSVAKTAQTDDRRRRKFRLDPDVAFLDTRDPKLDPHLSKQLGAFNAHSGVRKPPVHLVSQRHSAMTWQSGWKPRDYLVVHKSMRCSESAECYSVRCFVVTFDDGVYYSLLISRHVSLPHVHAYTSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US64</accession>
    <name>A0A1Y1US64_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_272763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874081.1">
        <property type="nucleotide sequence ID" value="XM_022012343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US64"/>
    <dbReference type="GeneID" id="33554151"/>
    <dbReference type="InParanoid" id="A0A1Y1US64"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX40296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="21098" checksum="4EB23D8307DB5F20" modified="2017-08-30" version="1">MSHYVLDELPALADSLRAICSPVLQQLQPSPLRVTGKIPALHVPEMSRLLPPVLLETLPAYLKNAIFSEVTRRLEEMRSCQLRIFGESMSRMLSSDISRQQGHSKMDEELEKSMVCIIERVYASNVDSIRTTVATAIASFNKQPSGRKTGGFKKDALEVLEAAFSRSAVLSQRECSLVAKAAGISHQQVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1US93</accession>
    <name>A0A1Y1US93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_616091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873840.1">
        <property type="nucleotide sequence ID" value="XM_022014790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1US93"/>
    <dbReference type="STRING" id="4999.A0A1Y1US93"/>
    <dbReference type="GeneID" id="33556598"/>
    <dbReference type="InParanoid" id="A0A1Y1US93"/>
    <dbReference type="OrthoDB" id="2422840at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="916" mass="99968" checksum="4EFBBFBB9DFE0CDB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USA5</accession>
    <name>A0A1Y1USA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_612510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874582.1">
        <property type="nucleotide sequence ID" value="XM_022014400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USA5"/>
    <dbReference type="GeneID" id="33556208"/>
    <dbReference type="InParanoid" id="A0A1Y1USA5"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="397" mass="42969" checksum="E532C038D39A5982" modified="2017-08-30" version="1">MPSTGAYIHKWWPLSSVTQFCLQLAKQTQAMNSGISEVEGSPGSSLVLVRSSIEPLPTADDSGNQTYRLSCGLCPQTQPNETLISIPEGTSEEAKSLIESARYIFGTCTGSCQSQLMVDNPWYKQEAEVRCWDELTTIQQPMTLPQEILRDMEWTTSDAVIVTAAPRSAFPASFGEMKSISIGWRSNKNEENDQGSKTFLLIPTRREVPYGPDSFGVPAPLQVTEGPQELAGNDLLSPGQTRRSSSILGRVFRRRSDSQARAPGLSLDSITSGIPDRMFRSVILRPLDHISRSHSSASVMTALFGMSRLATDNAWSIGSGLPRDGLASTNLNDSGAQITTSVSVPSVQVHGPEPVELSGDVTHPVELPAEDWLAGSEKSSFPSELDGKSTSLHELPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USW2</accession>
    <name>A0A1Y1USW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">KN homeodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_617207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874080.1">
        <property type="nucleotide sequence ID" value="XM_022014899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USW2"/>
    <dbReference type="STRING" id="4999.A0A1Y1USW2"/>
    <dbReference type="GeneID" id="33556707"/>
    <dbReference type="InParanoid" id="A0A1Y1USW2"/>
    <dbReference type="OrthoDB" id="2574029at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KN homeodomain" evidence="6">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="509" mass="56479" checksum="8CE9584B375727B7" modified="2017-08-30" version="1">MTKGLADHDAVIEIDFGASLDRLHQNTMTRLTDDPHDVSKLAQEWELLRARISLIEGEGRLAPNIVQKAYLYAANVAAAVKAVIGLESRTEETCRNLVRNISGVMDRAKTSDPERDNVIPPSDLSLSSPQILVGAPLPGTTNDHLRFWFLDNLASPYPTPNEKDNLANLLGVDRKKVDSDLTNWRRRAGWTDIKDTYCDKSRVLMKELMERVESGEETDQDILDAVENMKAYLERREEEKVGDWVHELASLAQPRKRVKQADGTSRAVSSNCSTLDLDLDEVDHHSLSQRPSISSLRAVADTVGRRTRSKATRKGRATDSSISSSSSWSLSSEAARGFTFAPSERTTSGVSDISIELQQTHGTSTDKNGPNKRALPSDMNTEQTAHPAIRMKTDMPITPYNQPGWCTPPSSSPRLFMNASPTEYNQTPMYTQAGGYFVQQNQQTPIYPQPDGFLPPPTYQSTNEGSSTSIWSTSNALPMLPHMMTNTVNGFMMPTTFAFQPQFGWQPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTE5</accession>
    <name>A0A1Y1UTE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_1625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874144.1">
        <property type="nucleotide sequence ID" value="XM_022012065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTE5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UTE5"/>
    <dbReference type="GeneID" id="33553873"/>
    <dbReference type="InParanoid" id="A0A1Y1UTE5"/>
    <dbReference type="OrthoDB" id="2564094at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="443" mass="46550" checksum="5296EE8111D7B64E" modified="2017-08-30" version="1">MPPIPVTIHSRPSASKSVMGLQSNSSSHNRSLTTNRSAPKYYTITTTTTTTTNIFNLTPAQPPVIVLPTASSSGSSSTPSPILTTITIKSSSQRRKAKVYRPSTNVAVASLTPLLQPIVTRCLPLKPDVSPASSHTALPSPPPVTKRGTVGNYAFKKSYRPPPPPPLTHIIHPYSRRWDTTNDRSPNPSPREVAKAQRLELEKVKVREESAAIARAAAAAKRKRGKAKSTTKNSAPTSKSESPPDKTVALEDGVPVITNEPASSKGSPTLTAPTPSASTIPPRAGLKRTRSIGLGISTTAANSANGQMAVGSPLRSVTGPISPEDESRDAKRTRLGESESGRIFRRGSSGSPVVPTQGLPGPSLRRASANGLTSEAIAMRRAVSATTLAQQTVNGGQSMTRTGSVGSTSSLGEALASGRDRARREVTLPGRLRDYEMRAGTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTL9</accession>
    <name>A0A1Y1UTL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_612665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874636.1">
        <property type="nucleotide sequence ID" value="XM_022014422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTL9"/>
    <dbReference type="FunCoup" id="A0A1Y1UTL9">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTL9"/>
    <dbReference type="GeneID" id="33556230"/>
    <dbReference type="InParanoid" id="A0A1Y1UTL9"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="137" mass="14939" checksum="B8B13445F7882A87" modified="2017-08-30" version="1">MPRGSQSKTVSAHRIGSLLFCPACGTLLDLPRDDQDEIPCAQCGRLEPASSYENLPTKTYSSPHAFPSPLKSKRGLVQNTMDDGEAAKERDPVAQEKCQKCGHIGLSYKVMQLRSADEGSTVFYKCLNCGDQTSLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUU6</accession>
    <name>A0A1Y1UUU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_644309</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 19"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874925.1">
        <property type="nucleotide sequence ID" value="XM_022017588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUU6"/>
    <dbReference type="FunCoup" id="A0A1Y1UUU6">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUU6"/>
    <dbReference type="GeneID" id="33559397"/>
    <dbReference type="InParanoid" id="A0A1Y1UUU6"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="346"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="409"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="433"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX41246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="552" mass="58145" checksum="DFF1FBF974174833" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUV5</accession>
    <name>A0A1Y1UUV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_612779</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874664.1">
        <property type="nucleotide sequence ID" value="XM_022014441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUV5"/>
    <dbReference type="FunCoup" id="A0A1Y1UUV5">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUV5"/>
    <dbReference type="GeneID" id="33556249"/>
    <dbReference type="InParanoid" id="A0A1Y1UUV5"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="124"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX40985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="451" mass="47787" checksum="0955F0A05C9D33BC" modified="2017-08-30" version="1">MMPGTSTDAQDTSGLTPDSFKDILKKLVQTPNEFTPEDCALAFKHLCLKDGASEAQAGAFLTALTLSGMESSPEVVAACAAVLRDHAIKVTSEQLNGGSSSTAKTGHWDYSDSDKEGDNYTGYCDIVGTGGDGWDTFNVSTTAAVVAAGAGVRMTKHGSKAATSTSGSADLLLSLDCRLSFPPSALSTFLPSSPFLFLFAPHYHPALAHIAPIRRQLNFRTIFNILGPLINPVRPARMMLGVARKDLGDTFARVLQLLNVERALVVCGKENLDEISPAGETWTWLLENGEITKGSIHPTEDFGLAIHPLSSVRGATPDLNALTFQTILANSATPPAHLSSPPSDDSPSLQSILDYVLLNAAALLFVSGRASSYKDGVKIARESIASGGARAAFEAFRDTSRLAMGEYVDVKTVEDDGGVAAKNGFVKAWLKARKERDESTPGTPVPELTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUZ3</accession>
    <name>A0A1Y1UUZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_614014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874975.1">
        <property type="nucleotide sequence ID" value="XM_022014553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUZ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUZ3"/>
    <dbReference type="GeneID" id="33556361"/>
    <dbReference type="InParanoid" id="A0A1Y1UUZ3"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX41296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="239" mass="26794" checksum="56B90737818EC1E2" modified="2017-08-30" version="1">MATAVVGFPSVPMMTHTMDVDMEGHEPELGDRSYAESNRSAYLQENQWTAYIEPIKDTVNMLNPDEELQDLEAAESAFGKIEEEREAMLQRLENEVNELAKQYEAAAQDAVRPKTLPPVEEHLAQVRDLERQQVSLGKSINEEQAKVVGKETELRDLKTRKDQIVNVDVGAEMAPDSKAARLKLLSDMGFTYIPGQGSSSSKILIRNEAKLDVHTVALDNKRAKAYYANVIWSMLGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6G8</accession>
    <name>A0A1Y1U6G8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_605790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867940.1">
        <property type="nucleotide sequence ID" value="XM_022014005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6G8"/>
    <dbReference type="FunCoup" id="A0A1Y1U6G8">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6G8"/>
    <dbReference type="GeneID" id="33555813"/>
    <dbReference type="InParanoid" id="A0A1Y1U6G8"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="30235" checksum="0B9A743FD789918C" modified="2017-08-30" version="1">MMNGSGAHINGQSRSQATPTPASASDLLPKAPHYREKGSIPNTPLAVSVISALLGGVALSSLTLAAQHLLGGSGLGGNWARPQLGIYGFAWGLFHLCEFWTTAGWNPLKLSVDAFLLNNTNQYHYAHLFGLGEYFLSSYFFPGKFDSRFCSAPVILAVCALLVGGQALRSLAMIHANASFSHVVKDIKHDDHVLITHGVYSLSRHPSYCGFFYWAIATQLLLGNIISTLVFIFILGRFFSSRIREEEKYLVRFFGDDYVQYRRRVGTGLPFLISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U706</accession>
    <name>A0A1Y1U706_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_638735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868122.1">
        <property type="nucleotide sequence ID" value="XM_022017152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U706"/>
    <dbReference type="STRING" id="4999.A0A1Y1U706"/>
    <dbReference type="GeneID" id="33558961"/>
    <dbReference type="InParanoid" id="A0A1Y1U706"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33210" checksum="670FCDFD1E02F071" modified="2017-08-30" version="1">MPAHPLPAIPSHSVWATKKAQDAEASFYEATNLPEPVWRERFAWEMRAAHSLFTNLVKRVYLFAHDAVEQDDLLNYLGFSEVAIYQVYNHHHFEETVIFPYLIEHGADRASLEGNVQDHHTFTRAMDATWLYIRRVRALLPDAARYPSPVPEPDEEIQTIDIVGEYGLDPSKGFDPTLLQKHMDTWLGTMMDHMLEEIDTIGPSMTEAVGEENLKQLGVIVLKHLQAYDPKWFLCSSFATVNMDCCKTLLKLPYLVRRILVPYVWAGKYWGMWQYCEHPENLTWAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7J9</accession>
    <name>A0A1Y1U7J9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_638012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868297.1">
        <property type="nucleotide sequence ID" value="XM_022017070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7J9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7J9"/>
    <dbReference type="GeneID" id="33558879"/>
    <dbReference type="InParanoid" id="A0A1Y1U7J9"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="138"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="243"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="401" mass="42927" checksum="727858D2E6021885" modified="2017-08-30" version="1">MSSSRPPLTPIGSALAGALGAVVSNAVVYPLDTVKTRLQALPDGPSLPSHATVPVPRPAKGVLGRDVIRIPERLWARIKKLKMLAMLIKIVKTEGLGGTFKGFTANMLNTFSQQFAYFFFHTWIRKAAMARLYNPHSLSTSSELLLGAAAGALAQIFTIPVSVVATRQQLWTPSDQDRSAGVYGLSLLETAKEIVEESGPSGLWTGLKPGLVLTVNPAITYGAFERIKSYVLSSREGGGGAGLSMMENFFIGVTSKAIATIVTYPYIFAKVRLQAKAGDNGPVPELAALEASVEKGVSYADAAAQEPASSAPVVAGPEKGVDPKRHPRPKHKHAGAITLLRAVYAEKGFGGWYQGIAAQLIKAVLCQGILFVSKDQFERWTWLILITLARLRARIPLVAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7N7</accession>
    <name>A0A1Y1U7N7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_214492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867873.1">
        <property type="nucleotide sequence ID" value="XM_022012195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7N7"/>
    <dbReference type="GeneID" id="33554003"/>
    <dbReference type="InParanoid" id="A0A1Y1U7N7"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="165" mass="17412" checksum="4C540338C569F5E6" modified="2017-08-30" version="1">MAGKTQTDPAKVPRQSTLLGFFGKPKPGPAAPSSSARPLSNKDVPVPASAPVAAGPSTSSPASTALRTPSSALGSSPSTVIARSRVRSTSPLKNVMNHDDDLSDDLTPPPLEARKSRSVVVEKEETVKEDIVMNHGGEDSPIVLVSWWSVRRLIICLVYPIEIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7U7</accession>
    <name>A0A1Y1U7U7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_638320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868371.1">
        <property type="nucleotide sequence ID" value="XM_022017100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7U7"/>
    <dbReference type="FunCoup" id="A0A1Y1U7U7">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7U7"/>
    <dbReference type="GeneID" id="33558909"/>
    <dbReference type="InParanoid" id="A0A1Y1U7U7"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="302" mass="35209" checksum="4E8A406FA17FC02E" modified="2017-08-30" version="1">MSRRLYLGRLNPSTNKNDIEDLFKNYKPVDIRTMGNFAFVELESSRDVEDASRELNGKDLLGEQIIVEPARDSRRREGYGERDPYSRPPPPASRIGLPKRGIKINVSSIPTSTSWQDLKDYGRMGSPNILYADIDRNDPTSGVIAFPNMEDAEEALRKLSGVDINGQPVKLELAPNEGLGDESMDRTYERRDIDRGGPGGYDRRPPPRDYYDRPPRGGYDDYDRRGPSRYDDRPRYDDRRYDDRRYDDRRDDRDGYGRREDRDGYRGGGGDRPPRDRDYDRDRARSPPRRRDDDRYARDDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7Z3</accession>
    <name>A0A1Y1U7Z3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nife hydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_643832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867974.1">
        <property type="nucleotide sequence ID" value="XM_022017571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7Z3"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7Z3"/>
    <dbReference type="GeneID" id="33559380"/>
    <dbReference type="InParanoid" id="A0A1Y1U7Z3"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="117"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="387" mass="44021" checksum="F0840D5194787CBC" modified="2017-08-30" version="1">MKHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHIGLLHRATEKLIEYKTYTQALPYFDRLDYVSMMTNELCFSLAVEKLLNIQVPDRAQWIRTLFGEITRILNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARMHAAYVRPGGVAFDIPHGLLDDIFKWATQFSSRVDEIEELVTGNRIWKQRTVNIGVVTAQEALDYSFSGVMLRGSGVPWDLRKVQPYDKYAEVEFDIPVGKNGDCYDRYLCRVQEFRESLRIINQCLNKMPAGAVKVDDHKIVPPPRASMKESMESLIHHFKLFSEGYSVPPGETYSAIEAPKGEMGVYLVSDGTNRPYKCKIRAPGFAHLAGSDFMMRDHFLADAVTIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U831</accession>
    <name>A0A1Y1U831_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD324DRAFT_647207</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867967.1">
        <property type="nucleotide sequence ID" value="XM_022017637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U831"/>
    <dbReference type="FunCoup" id="A0A1Y1U831">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U831"/>
    <dbReference type="GeneID" id="33559446"/>
    <dbReference type="InParanoid" id="A0A1Y1U831"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="46"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="280"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="573"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="573"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ORX33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="687" mass="77327" checksum="19222FD550B9CB5B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8G9</accession>
    <name>A0A1Y1U8G9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_653857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000017">
        <property type="protein sequence ID" value="ORX33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868105.1">
        <property type="nucleotide sequence ID" value="XM_022018716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8G9"/>
    <dbReference type="FunCoup" id="A0A1Y1U8G9">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8G9"/>
    <dbReference type="GeneID" id="33560525"/>
    <dbReference type="InParanoid" id="A0A1Y1U8G9"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="280" mass="31391" checksum="00EBF81A3746B373" modified="2017-08-30" version="1">MRYAVLVTGPAGAGKSTFCASLITHAQTLGRSVHLVNLDPAAERFEYEPALDIRDLINLKDVMEELEFGPNGGLIYCFEYLLNNLYWLEDELGPYEDDYLIIDCPGQIELYTHIPLLPRLASHLSTSLNFRVSATYLIDSQFMQDKSKFFAGVMSAMSCMLSLGISMVCIMSKMDLVKDKKGRLKKEVGRYLDPDPGLMWEEIKDDSDGGSTGNRKFDALNRAVVGLIEDQNLVSFLPLDVTSEDSVNTILSHIDNMMQYGEDEEPRIPKDMDDGDFDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8V4</accession>
    <name>A0A1Y1U8V4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemerythrin HHE cation binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_636053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868733.1">
        <property type="nucleotide sequence ID" value="XM_022016861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8V4"/>
    <dbReference type="STRING" id="4999.A0A1Y1U8V4"/>
    <dbReference type="GeneID" id="33558670"/>
    <dbReference type="InParanoid" id="A0A1Y1U8V4"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="210" mass="24192" checksum="BB3A724B1B561127" modified="2017-08-30" version="1">MLTVLATAARTIPKRYISLSTQRLPTLNMSTISAVITHDHREIEDYYKQILTAEDEDAKTRYQNQFTWELARHSLGEELVIYPLMEKVVPGGQAMAQKDRAEHQKVKEQLNLFQGMKASNPEFEPTLRALMSNLSEHIKEEEHDDLPKLEEHISREDSASVAKEFQRTKKFVPTRSHPSAPDKPPFETVVGLMTAPMDKLQDMFRKFPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8X0</accession>
    <name>A0A1Y1U8X0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_214576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867874.1">
        <property type="nucleotide sequence ID" value="XM_022012196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8X0"/>
    <dbReference type="FunCoup" id="A0A1Y1U8X0">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8X0"/>
    <dbReference type="GeneID" id="33554004"/>
    <dbReference type="InParanoid" id="A0A1Y1U8X0"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX33555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="417" mass="47251" checksum="4A0D1C1828A2CEF3" modified="2017-08-30" version="1">MAEVTPSKVAAAALSHINLNTTNPANKPAEHTLMAKLKAAAAEVQAKAEVKSVAATATAVNVTETEGSEEVEEYRTRFVGDLECEEKDEPLLQETTSRFVLFPIKYREIWQMYKKAQASFWTAEEINLAPDLHDWETKLNDNERYFVERVLAFFAASDGIVNENLVERFSSEVQCAEAKCFYGFQIMMENIHSETYSLLIDTYIKDANHRTFLFEAIDTIPCIQKKAQWALKWITDKRSTFAERLIAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLFTHLRRRPHPETVERIIREAVKIEQEFLTDALPCSLIGMNSKLMCQYIEFVADRLLVALGNEKVWNATNPFDFMEMISLQGKANFFESRVSAYSKSGVNQSVGADGDHQAVKKGFSLDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U994</accession>
    <name>A0A1Y1U994_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_162114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868863.1">
        <property type="nucleotide sequence ID" value="XM_022012064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U994"/>
    <dbReference type="GeneID" id="33553872"/>
    <dbReference type="InParanoid" id="A0A1Y1U994"/>
    <dbReference type="OrthoDB" id="2564969at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25620" checksum="C4D38B22218CAE3A" modified="2017-08-30" version="1">MPSDKPSGALSSSPSSRSKTRLSGSDYDKHSGFIDSCLKSHAEYLAQPTLIIAQSLGVSPLHLSYGVGAVILALHLVLPAFLLPHFSALFTLIPPVQSSLQSITLETKKSGRDARDAAQWCIYWVIYTFFELARGSVSVYLPGVVPFFELSRSVCLIICGGPWFGRAGLVSAFFLADFASPTDNLQRPDAARKEDDKTPEKHRSKRSKQNGGESRAGSKKDEKERRDTTSKDKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9B6</accession>
    <name>A0A1Y1U9B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_653375</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868374.1">
        <property type="nucleotide sequence ID" value="XM_022018649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9B6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9B6"/>
    <dbReference type="GeneID" id="33560458"/>
    <dbReference type="InParanoid" id="A0A1Y1U9B6"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="572" mass="60110" checksum="A829094692922A8C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9R0</accession>
    <name>A0A1Y1U9R0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_583229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869010.1">
        <property type="nucleotide sequence ID" value="XM_022013607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9R0"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9R0"/>
    <dbReference type="GeneID" id="33555415"/>
    <dbReference type="InParanoid" id="A0A1Y1U9R0"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="101"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="491" mass="54778" checksum="937477352EEE35DD" modified="2017-08-30" version="1">MSASTTHAQSSSRDPEPNRQSSINSGLEVDDDEDDVLLDLSRLQSFASRVQYVAAEENQAGPSSIRPKMTIPKRGEKDFEPLEETVNLQDMMLQRSREALFSALLGVRGGNIQSISQAIILPSSPYPRILTTRGHLMDSMGISISGPAVKPQKRRQTHTELLPEEALYLLERGSLQIWIPNTAKVNGGSTPSNVDWNDTDFGFEDCIEMSVMQGFSFFLGKDGLTWERYQAYAYLKRLGYTVQRSRRFLPTRFLGGTSESAAQLPLSNPGLPPFRSWWLSIPVVLRRCFGALGTVISRLLWHRSWSRRQVLERSALQGWSGRTYSSIGLHLHCSQSGLSTWGRARMTRIAPSDRMTNPYTPFWHVWKPDRPWSKAQWDKSSAAGLARQPFDFAVAAVDARAEPLPSLEQLDEIFDSLPQETDTRPRPVVDGVTAVTTTAQAPPQPNRPSPKGRSVPSIRNGDRAFVVAVNDSGNQGWVRFGRTGFASIFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAB1</accession>
    <name>A0A1Y1UAB1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_652695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869189.1">
        <property type="nucleotide sequence ID" value="XM_022018537.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UAB1">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAB1"/>
    <dbReference type="GeneID" id="33560346"/>
    <dbReference type="InParanoid" id="A0A1Y1UAB1"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1874" mass="207420" checksum="052CBAE0CE457F44" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAG9</accession>
    <name>A0A1Y1UAG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_633667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869249.1">
        <property type="nucleotide sequence ID" value="XM_022016644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAG9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAG9"/>
    <dbReference type="GeneID" id="33558453"/>
    <dbReference type="InParanoid" id="A0A1Y1UAG9"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="713"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="713"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="789" mass="85971" checksum="8186C3828484C9D7" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAU0</accession>
    <name>A0A1Y1UAU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_170815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868473.1">
        <property type="nucleotide sequence ID" value="XM_022012084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAU0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAU0"/>
    <dbReference type="GeneID" id="33553892"/>
    <dbReference type="InParanoid" id="A0A1Y1UAU0"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="1">
        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="252" mass="26526" checksum="09B22C96B7B307CF" modified="2017-08-30" version="1">MVCLTDRHRVCICLHLGVLTQASKDNIVAAVEASANAQVVGQLTTAVGAYAAPFASQNAIVALLEQQALANVGGMKSNCNYPTGSTPDSCTDCHSSCPDGQYVCGNACISDNDGCSSGQAVPPKKRDFLSVITTPRCPSMLTACAVPASSFFTGRNFECLDVMSDIESCGACTFPLPGEKSGIDCTSIPHTLGVKCHLGKCVIDSCQQGFELSTDGAKCVPGNKRILKEKRRTAKNAIKSRQVKTADLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAU2</accession>
    <name>A0A1Y1UAU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_634413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868906.1">
        <property type="nucleotide sequence ID" value="XM_022016724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAU2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAU2"/>
    <dbReference type="GeneID" id="33558533"/>
    <dbReference type="InParanoid" id="A0A1Y1UAU2"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013344940" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="77"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="323"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="563" mass="62933" checksum="A804FA6E70AD0A9D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBB0</accession>
    <name>A0A1Y1UBB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD324DRAFT_642994</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869520.1">
        <property type="nucleotide sequence ID" value="XM_022017520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBB0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBB0"/>
    <dbReference type="GeneID" id="33559329"/>
    <dbReference type="InParanoid" id="A0A1Y1UBB0"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ORX35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="556" mass="61518" checksum="99FA6DC11646A835" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBE8</accession>
    <name>A0A1Y1UBE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_652504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869561.1">
        <property type="nucleotide sequence ID" value="XM_022018506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBE8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBE8"/>
    <dbReference type="GeneID" id="33560315"/>
    <dbReference type="InParanoid" id="A0A1Y1UBE8"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047343">
        <property type="term" value="F:glucose-1-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02524">
        <property type="entry name" value="G1P_cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046981">
        <property type="entry name" value="G1P_cyt_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013446">
        <property type="entry name" value="G1P_cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02623">
        <property type="entry name" value="G1P_cyt_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183:SF1">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47183">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE CYTIDYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="261" mass="28825" checksum="249ECB1937789E72" modified="2017-08-30" version="1">MKAVILAGGLGTRLAEETGLRPKPLVEVGGKPILWHILKIYSAHGINDFVICLGYKGHMIKQYFADYLLTCSDVTIDMNDCSVTLVDTGSGTGTGGRLRSVAKYLQGERTFCMTYGDGVADVDLSALIEFHQSHGKAVTITAVQPVARFGALGLEHHKVLEFQEKPQDEGGWVNGGFMVLDPVAINAVTNDDEMFEQEPMERLVKEGEVQAFFHHGFWQAMDTLRDKQTLEKMWEKGDAKWIINDKVKNGNGGAYKVNGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBG5</accession>
    <name>A0A1Y1UBG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_582147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869588.1">
        <property type="nucleotide sequence ID" value="XM_022013545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBG5"/>
    <dbReference type="FunCoup" id="A0A1Y1UBG5">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBG5"/>
    <dbReference type="GeneID" id="33555353"/>
    <dbReference type="InParanoid" id="A0A1Y1UBG5"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="351" mass="38841" checksum="CC88F2F879A00EAA" modified="2017-08-30" version="1">MARKPLYLNSKTLTSHLFFGPYIFFPILAGLTWLGGILALLGLWVHAGKPRYEAEEASVVFISDVGAAHHKLFIGICCTTAGLYVMSIIAERWLRHVDRLPADKRKRERVFDWMAIVFGAIGALGLVFLSIFDAFDYPKVHWSMTVVFVVFVALSAIFQSAEVWSLYKDHPDRPHLLRNSILKLIIVTLAICTAIAFAVTYGYCDGNSVAVKGHSAAKCNRVTSAAAALEWTVAFILVFYFFTLAADLWPAGKSSPRYMRRLAKWQEKHGEGDDFTGRRAFSEYPERWQGAAANEEVGGGGGWRARAERMKIASKEKNQGIAPGRDSMASGAPLRTANGGDTREPSAETTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBH6</accession>
    <name>A0A1Y1UBH6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_582192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869598.1">
        <property type="nucleotide sequence ID" value="XM_022013549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBH6"/>
    <dbReference type="FunCoup" id="A0A1Y1UBH6">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UBH6"/>
    <dbReference type="GeneID" id="33555357"/>
    <dbReference type="InParanoid" id="A0A1Y1UBH6"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="167" mass="18755" checksum="37C6694049D7D86B" modified="2017-08-30" version="1">MPGVRDVSAEAFIKAYSSHLKRSGKLDIPTWVDTVKTGCQKELAPYDPDWYYVRAAAVARHIYLRKSVGVGALAKLHGTKKRRGTRPNRHQDSSTGVQRSVVQGLEKIGVLELAQDGGRRISQDGMRDLDRIATAVLEQERAEEDEEEEDEDEDEDEDEAEEEADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBN8</accession>
    <name>A0A1Y1UBN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AraC-type arabinose-binding/dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_582684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869160.1">
        <property type="nucleotide sequence ID" value="XM_022013574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBN8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBN8"/>
    <dbReference type="GeneID" id="33555382"/>
    <dbReference type="InParanoid" id="A0A1Y1UBN8"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014500">
        <property type="entry name" value="UCP019307_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019307">
        <property type="entry name" value="UCP019307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC-type arabinose-binding/dimerisation" evidence="2">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="174" mass="19633" checksum="17B19C7C02E8F980" modified="2017-08-30" version="1">MRLTPLSQLNTTRRHIQAHGLIPNTSSCHPLVIYHSAFPPTVTATDIESHLRHIDVVVPAWRYTMYSFDHFHATTHEVLCVYSGQAKLCFGGETNPDRVLINAQKGDVILLPAGVCHRLLEELEKPFMMVGSYPHEKRPDMCYGIETEEESIRKIADLGWFETDPIYGGGSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBR5</accession>
    <name>A0A1Y1UBR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_156655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868788.1">
        <property type="nucleotide sequence ID" value="XM_022012047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBR5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBR5"/>
    <dbReference type="GeneID" id="33553855"/>
    <dbReference type="InParanoid" id="A0A1Y1UBR5"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="127"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="34075" checksum="B490A95CE8901E46" modified="2017-08-30" version="1">MPIALDDKVDASSSSYAHVDPKSFPALDHFQIKNIPPAAYYIPDFITAQEEEYLLRKLEESPQPKWKKVGSGRRLQYWGGTMSSGGTLLPEPLPEWLTSFPDIIQRIDSFLDVASGHEYTGHGRVLGINQVLVNEYQPLQGISPHEDGPAFRPLVATLSLGSHTVLDIHQYLSTTTPSPPMVATLASSTDTSAGRPIAAIPLAHLLLLPRSLLILSSSLYTSHLHGIAARMSDSVLSRPLPSASLQPDSMDDPPVIISNADLLGDPDIMDRLRADTSSWKAERGVRTSLTFRHANKVLKGGAFAMAQGALRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBS8</accession>
    <name>A0A1Y1UBS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_610110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868798.1">
        <property type="nucleotide sequence ID" value="XM_022014188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBS8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBS8"/>
    <dbReference type="GeneID" id="33555996"/>
    <dbReference type="InParanoid" id="A0A1Y1UBS8"/>
    <dbReference type="OrthoDB" id="2596887at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="412" mass="45022" checksum="2A42090905CCEB5E" modified="2017-08-30" version="1">MTGDRFSQLLEAKLGPNPSLNLQNNADRRPRASLVSQLGPTTETEDMSTFDRAGIEQVLRDYSGTQTPSEAISTMLHPQQYGMLSLLSVDENNMSRAVPSSEAYSFSGGHSQFVPSSAPPSSNNHPPPPPRNDLQTSNLPAYLVQSQLAPFTDLFSHPFQSTSNHSPHNVRLDPGAPATPLSRGDAVDGSWAMELLKGYKSAQNRLQFPDRGTQVDHAVSLPHPVKKAHSQHTQATPSRSHPPTSPAQDAARRSTSQTSRRSPRQSRDNSQGSSDESAYEPKGRKRRTISSSRSVKKESAATVEEDGEKKPVIACHMCRARKLKCNGVRPKCANCVRRNEDSCEYDTVLRRRGPGRNNKKDRRSRTGGAVATGRARGRGQVDSSMDRLTPHGTEEGSDMTLLGMGNISAHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBY3</accession>
    <name>A0A1Y1UBY3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phage tail collar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869686.1">
        <property type="nucleotide sequence ID" value="XM_022018435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBY3"/>
    <dbReference type="GeneID" id="33560244"/>
    <dbReference type="InParanoid" id="A0A1Y1UBY3"/>
    <dbReference type="OrthoDB" id="3493401at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1340.10">
        <property type="entry name" value="Phage tail collar domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011083">
        <property type="entry name" value="Phage_tail_collar_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037053">
        <property type="entry name" value="Phage_tail_collar_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07484">
        <property type="entry name" value="Collar"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88874">
        <property type="entry name" value="Receptor-binding domain of short tail fibre protein gp12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage tail collar" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Phage tail collar" evidence="2">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="524" mass="56018" checksum="E8677DC90EA8E6F0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UC44</accession>
    <name>A0A1Y1UC44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">BD324DRAFT_634351</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34 35">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868897.1">
        <property type="nucleotide sequence ID" value="XM_022016720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UC44"/>
    <dbReference type="STRING" id="4999.A0A1Y1UC44"/>
    <dbReference type="GeneID" id="33558529"/>
    <dbReference type="InParanoid" id="A0A1Y1UC44"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23 34" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="32">
        <location>
            <begin position="603"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="33">
        <location>
            <begin position="780"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="870"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="31">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="ORX34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="924" mass="97736" checksum="B6D1345A402CAD4E" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCI7</accession>
    <name>A0A1Y1UCI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_631556</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869924.1">
        <property type="nucleotide sequence ID" value="XM_022016445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCI7"/>
    <dbReference type="FunCoup" id="A0A1Y1UCI7">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCI7"/>
    <dbReference type="GeneID" id="33558254"/>
    <dbReference type="InParanoid" id="A0A1Y1UCI7"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="214" mass="24204" checksum="5B1BAF0462142D80" modified="2017-08-30" version="1">MVNRGLFIVLEGLDRSGKSTQVSRLHDQLEQDGHKARIQKFPDRITAIGKMIDSYLRSEAELDDRAVHLLFSANRWECCQAIEQSLQDGVTVIADRYAFSGIAFSAAKGLPFDFCASPDIGLPLPDVTLYLTVSPAAAAKRAAYGTERYEQVDLQNRVREQFKLVADKVRTMHGPDRWVEVDAEGSIDQVWERIWSQVKAIESKKGEQIHRLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCR4</accession>
    <name>A0A1Y1UCR4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_632230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869486.1">
        <property type="nucleotide sequence ID" value="XM_022016499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCR4"/>
    <dbReference type="FunCoup" id="A0A1Y1UCR4">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCR4"/>
    <dbReference type="GeneID" id="33558308"/>
    <dbReference type="InParanoid" id="A0A1Y1UCR4"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="455"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="727" mass="78143" checksum="FEE042A9EE4FACC0" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDJ9</accession>
    <name>A0A1Y1UDJ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_64346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869791.1">
        <property type="nucleotide sequence ID" value="XM_022017547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDJ9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDJ9"/>
    <dbReference type="GeneID" id="33559356"/>
    <dbReference type="InParanoid" id="A0A1Y1UDJ9"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="77354" checksum="D59FF54026621E93" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDL7</accession>
    <name>A0A1Y1UDL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_630078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870208.1">
        <property type="nucleotide sequence ID" value="XM_022016292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDL7"/>
    <dbReference type="FunCoup" id="A0A1Y1UDL7">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDL7"/>
    <dbReference type="GeneID" id="33558101"/>
    <dbReference type="InParanoid" id="A0A1Y1UDL7"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX36079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="368" mass="40386" checksum="7F05AA4FD7D894C9" modified="2017-08-30" version="1">MTTAQKIKDIEDEMAKTQKNKATEYHLGQLKAKLAKLRRELITPSGGGGGGPGIGFDVARTGVASVGFVGFPSVGKSTLMSKLTGTHSEAASYEFTTLTTVPGTLTHNGARIQVLDLPGIIEGAKDGKGRGRQVIAVARTCNLIFIILDVLKPLVDLAILTNELEGFGIRLNKRPPAITVKKKESGGVHITNTVPLTKVDPQEIKAVCSEYRLNSCAISVHQPDATIEDFIDVIEGNRVYVPAIFVLNKIDAISIEELDLLYKIPNSVPISSKMWLNIDELMEVMWDKLNLVRVYTKPRGQAPDYSSPVVLRRGRCTVEDFCNAIHKEIVKQFRNAMVWGTSAKHSRGQKVGLDHILEDEDIICIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDM0</accession>
    <name>A0A1Y1UDM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_630410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870287.1">
        <property type="nucleotide sequence ID" value="XM_022016326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDM0"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDM0"/>
    <dbReference type="GeneID" id="33558135"/>
    <dbReference type="InParanoid" id="A0A1Y1UDM0"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="338" mass="36615" checksum="B62017C067D8B000" modified="2017-08-30" version="1">MDEDALLRRFNALRAPSHVLLDIEGTGGERSAGEHDAETIAAAAAAAEREDRWLEDIADGKPAIAQKRGGDLPSSLLSGSEDDHRELERRVRALTGRRRQSSDHMSDHADEEVEAYLANLASTDPPEGDFSDPLADRGSSSATKSVLARDARRALDAASAVLPRDGQAGEEEVANDDGETEEEILARALAEAALEKDQLPSDDPHETISNTSFAFPSLPSHIPVDEDPEPGPEVNIDDDTRKRMDLLLGLSGPAQKPGQASLPAVPKRAPGQGWNLPGYNDARDDDLESWCCICNKDAELVCLGCDSDLYCAACWTDGHAFEKHRTKKFTWNRKAMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDP1</accession>
    <name>A0A1Y1UDP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger Mcm10/DnaG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_652025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870251.1">
        <property type="nucleotide sequence ID" value="XM_022018427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDP1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UDP1"/>
    <dbReference type="GeneID" id="33560236"/>
    <dbReference type="InParanoid" id="A0A1Y1UDP1"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="391"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="645" mass="70770" checksum="9A6D975E06F920AE" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDU6</accession>
    <name>A0A1Y1UDU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_581752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869858.1">
        <property type="nucleotide sequence ID" value="XM_022013522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDU6"/>
    <dbReference type="FunCoup" id="A0A1Y1UDU6">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UDU6"/>
    <dbReference type="GeneID" id="33555330"/>
    <dbReference type="InParanoid" id="A0A1Y1UDU6"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="457" mass="50135" checksum="85FAD5C5DDF35EEF" modified="2017-08-30" version="1">MSPIAVPVPNGSTASKNKMSSQEVMDLEHEYSAHNYHPLPVCFDRGEGAHVWDPEGNEYLDFLAAYSAVNQGHCHPEILNTLITQASKLTLSSRAFYSSNLGPFAQKITQMFGFESMLPMNTGAEAVETAIKMARKWGYMKKGIPEGKAIVLSVEGNFHGRTIGIISMSTDPEATRGFGPYLEGVGPRCLAGGKDRVIRYNHPEDLERALEAHGKEVAAFLVEPIQGEAGIYVPDDGYLTKCAELCKKHNVLFICDEIQTGLARTGKMMCYEWDGVKPDMVILGKALSGGMYPVSCVLSSKEIMHCIKPGEHGSTYGGNPLGCAVAMTALDVLVKEDLAARSMKLGEIFRDELRKLDSPLIKTIRGRGLFNGVVIDETKSSKGRTAWQFCLLMKSKGLLAKPTHINIIRFAPPLVISEEDIRKAVKIIGECLEEFDTIERIPGDEGEEHDVKVDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE09</accession>
    <name>A0A1Y1UE09_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_485428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870381.1">
        <property type="nucleotide sequence ID" value="XM_022012915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE09"/>
    <dbReference type="FunCoup" id="A0A1Y1UE09">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE09"/>
    <dbReference type="GeneID" id="33554723"/>
    <dbReference type="InParanoid" id="A0A1Y1UE09"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="393" mass="41451" checksum="9F138D215D32ECA5" modified="2017-08-30" version="1">MSSSHELVAAAVATTAAAAGAGGSSSTSDQGFATPSTTAYSSRHGTEGGGSGMTAVTMNEEAGHGAESSKMAIEGGDSATHAMGFSDYIWNVGYLQAQWTDVQLVFFDQSINLHRIVLSRSPYLAQLMAPHPPGTSIRLLLPDLNITSTSIHIALQHLYNPALRLVDSSNARSVLATAYIFGGMSELVQHAYRIIRQSFSPSNIVDNIHWLGQHSTGPSISGTPASIDSPSSRGGLAFGTLDGGDGVSSPRSQSSVSGWREAAQTAPYGEWSSRLRDDMTDYLINIFPASLPEPLSSDPTLFNIYCQLPYDLFKLCIESPDLPIGTTQARFTFAKKVIAQRKKLAGANKGASGPLMEEMVLLAVGTDSGSVEITRRPKKGKTTLVKAGPGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE17</accession>
    <name>A0A1Y1UE17_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_631543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869920.1">
        <property type="nucleotide sequence ID" value="XM_022016441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE17"/>
    <dbReference type="GeneID" id="33558250"/>
    <dbReference type="InParanoid" id="A0A1Y1UE17"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59963" checksum="3F00D74C12A5AC63" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE34</accession>
    <name>A0A1Y1UE34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome 60S biogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_682684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869525.1">
        <property type="nucleotide sequence ID" value="XM_022019160.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UE34">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE34"/>
    <dbReference type="GeneID" id="33560969"/>
    <dbReference type="InParanoid" id="A0A1Y1UE34"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="709"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1550"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1909" mass="210069" checksum="6A8AF9F1DB1506E6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEQ6</accession>
    <name>A0A1Y1UEQ6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_628979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870570.1">
        <property type="nucleotide sequence ID" value="XM_022016159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEQ6"/>
    <dbReference type="GeneID" id="33557968"/>
    <dbReference type="InParanoid" id="A0A1Y1UEQ6"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="153" mass="16422" checksum="FA6C46CEB042081B" modified="2017-08-30" version="1">MASNGGGSVCGQIDPNTSTEQAPYEHGRAVSGIWSELFPAPEIATEKTATSKQLWQDPPDNAESRASEQPAKPGFFQRGAKKPRPKLSYSQLTGYDGQRFDPLQGTNFNTASALSESAGPTGTELEDPQGNTDTERQTATESRNKLSSRCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEZ1</accession>
    <name>A0A1Y1UEZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_592258</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870213.1">
        <property type="nucleotide sequence ID" value="XM_022013814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEZ1"/>
    <dbReference type="FunCoup" id="A0A1Y1UEZ1">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEZ1"/>
    <dbReference type="GeneID" id="33555622"/>
    <dbReference type="InParanoid" id="A0A1Y1UEZ1"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="282"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="432"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="716" mass="77669" checksum="004DE6F5CE34BA29" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF22</accession>
    <name>A0A1Y1UF22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">XLF-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_630196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870235.1">
        <property type="nucleotide sequence ID" value="XM_022016304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF22"/>
    <dbReference type="STRING" id="4999.A0A1Y1UF22"/>
    <dbReference type="GeneID" id="33558113"/>
    <dbReference type="InParanoid" id="A0A1Y1UF22"/>
    <dbReference type="OrthoDB" id="2564800at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="346" mass="38862" checksum="9096D1D2BE73A742" modified="2017-08-30" version="1">MSSFQDKHDRVLRDVPWLSKEIDGQAWLFKYASHPERAGYVVLATNLEQVYFESVTGEAISARLNELSQSSQKRSESQIGSFNIMARVDDTLTELGGIMSERWQDNKLKAGTHHFYDKVFSIQDGDFEWSFFLSELELRRCLSLIGQHLVLPLARMIGKDNSISVSPSSTPSLAIAMILQDETVADKLNAQAGPSATHPEQEMEHTLSPKASPHSTREELEEETQDYKSGGDDHEKVEETQPPPSTQRPNLDPPAESAPVPSPTLQDNNVMDSDEEDEAAREAPADVKVPESLGQNAPDPPPKASQKSKKEREREEEEEVEKRREEMKRKMENGGGGRLGKRKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UF55</accession>
    <name>A0A1Y1UF55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_652039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870265.1">
        <property type="nucleotide sequence ID" value="XM_022018429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UF55"/>
    <dbReference type="FunCoup" id="A0A1Y1UF55">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UF55"/>
    <dbReference type="GeneID" id="33560238"/>
    <dbReference type="InParanoid" id="A0A1Y1UF55"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX36136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="49139" checksum="F066F27141348F75" modified="2017-08-30" version="1">MNPANAPCAAASSSRPAYKRVEEGERWFIDSGRIEILYLIGAGAYGCVYLGVDSSGPEPRYRAIKCLQRHGLDARQRHFQRRELALHRLACAHPSIVSMEKIVEDEEHLFVVMDYGEDGDLFSMITDKQRYVGDDELIRNVFLQLLDGVDYLHSIGIAHRDVKPENIVCSEDGERVVLCDFGLATSERTSSEFGCGSSFYIAPECLGEWFPDRTTYPTQPGDVWSLGVILVNLVCGRNPWRIASPNDESFNAFLADPLFLRRILPISNQCLYILTRIFTVDPSERIDTHLLRQLILQVDSFSMDEVELRATHLAAQARGVGKVSVEHVETCSVSTSLDTPSWGHESTFTYDQETPSLRADSGSPSPPIHRSTSSSSNDDASLPPTPLMHPQDISRGVLPPAASPLWAALKNADAQSRRKDPVELRINPSPDVLSESHPSPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFI3</accession>
    <name>A0A1Y1UFI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_628108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870367.1">
        <property type="nucleotide sequence ID" value="XM_022016085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFI3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UFI3"/>
    <dbReference type="GeneID" id="33557894"/>
    <dbReference type="InParanoid" id="A0A1Y1UFI3"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045:SF34">
        <property type="entry name" value="ISOFLAVONE 7-O-GLUCOSYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 72B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX36266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="523" mass="58612" checksum="EB14D16976D50A48" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGC1</accession>
    <name>A0A1Y1UGC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_630187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870234.1">
        <property type="nucleotide sequence ID" value="XM_022016303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGC1"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGC1"/>
    <dbReference type="GeneID" id="33558112"/>
    <dbReference type="InParanoid" id="A0A1Y1UGC1"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="792" mass="87080" checksum="E86A1BBB2B3008DD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGK7</accession>
    <name>A0A1Y1UGK7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_651130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870713.1">
        <property type="nucleotide sequence ID" value="XM_022018274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGK7"/>
    <dbReference type="GeneID" id="33560083"/>
    <dbReference type="InParanoid" id="A0A1Y1UGK7"/>
    <dbReference type="OrthoDB" id="2592905at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010999189" evidence="1">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="309" mass="32722" checksum="D7ADADB2452E525F" modified="2017-08-30" version="1">MRILLWQMLLIALRILPSAIAHAATNLAPRQDSSSSDTPSTTAVSSEVAFLQTLQMAQITSFSCVITLVNMTTTPIGNCLGLTTLAQLILNPSTNASFSTQLNTYLGGVCANGQCSNQAIAEAKGQLAGTCQSGTNNTLISVLDAILDNYSNSYFTLACKVHFNGTADLCLPASLNTSQNGNNNDFFNSLVTGDNLDAYSQSVFGSSQCTGCIHEMYKAAVYTLSKIRGQPLTESFGNHLQNDCQGQGGNIDWTNVQDQQIPDALQVQQATPGQNGGSIRQSVVNVAILSLVCLVIGGSVLWSTDFIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGN1</accession>
    <name>A0A1Y1UGN1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_650826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871258.1">
        <property type="nucleotide sequence ID" value="XM_022018211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGN1"/>
    <dbReference type="GeneID" id="33560020"/>
    <dbReference type="InParanoid" id="A0A1Y1UGN1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="567" mass="62601" checksum="A8FA6BB49DC1F48B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UGN7</accession>
    <name>A0A1Y1UGN7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin cortical patch SUR7/pH-response regulator pali</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_434317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871269.1">
        <property type="nucleotide sequence ID" value="XM_022012775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UGN7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UGN7"/>
    <dbReference type="GeneID" id="33554583"/>
    <dbReference type="InParanoid" id="A0A1Y1UGN7"/>
    <dbReference type="OrthoDB" id="3349852at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="253" mass="26550" checksum="92870DAC64E9D451" modified="2017-08-30" version="1">MRGEHCIAGASVLSAIAIILLVFVNIGQIGTGALVSGIYMAQVNVAAYGAAVQAATKSTPNGLYDTQNNPLGTSAGLRQYYRYGIYRACAYQKDGSGICSDSSFGHPMEPYGDVLADTPSKFKSTFNQIVPNSTYKNDSYNSAMTRIGGLLIFVGSALAAVALILGVLKSKVFFFGAATCSGLSAFLLLIGATLWTACIAQDSSIADYAVAKTQNLGITTTAGAGLYLTWAAFVFVTLSVLPYVIACCTFRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH23</accession>
    <name>A0A1Y1UH23_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_650922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871360.1">
        <property type="nucleotide sequence ID" value="XM_022018233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH23"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH23"/>
    <dbReference type="GeneID" id="33560042"/>
    <dbReference type="InParanoid" id="A0A1Y1UH23"/>
    <dbReference type="OrthoDB" id="2575097at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX37322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="413" mass="44354" checksum="4EB4E99A4B013AB8" modified="2017-08-30" version="1">MSSKELVPLFPSALHPALPIASQILSTLRNLTAPGRGNDLPPEERAALVGISALLGCERVQSKDLVESSAQKASSVSPARFKSALLKSRRILESASVGDPSLDASTSRRGSSASPSTRSTRSTRSHADQADADQVANTGEKRGSGPSPFSTPRKRFKYSSGIDISGLVKGGLAGGGSPPNTPKHQHEPSTGSPLRQSVTPSSRRVRSALRGGRVTEKKNDEEDGVVKEDEIRAGSEAEAAMIDEDAMEVDGQEERTPTKRVKFGVRQGVDLAIATEELDETPRTRSKRLDTSAFFALRPGASPSGSTARSLRNAQTSSGMKSRSIPVEDGLPEIRAPRANRSTTTSQKLKRRKRDWTYAERIWGLQTDESREAIRKFVDGLPAWLEAHGRPSLDETAVSGETIENVLLSASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH37</accession>
    <name>A0A1Y1UH37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="6">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BD324DRAFT_650970</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871411.1">
        <property type="nucleotide sequence ID" value="XM_022018240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH37"/>
    <dbReference type="FunCoup" id="A0A1Y1UH37">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UH37"/>
    <dbReference type="GeneID" id="33560049"/>
    <dbReference type="InParanoid" id="A0A1Y1UH37"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="13 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="203"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="739"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="27">
        <location>
            <begin position="1004"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="ORX37373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1155" mass="127028" checksum="2A63317CDAABD230" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH65</accession>
    <name>A0A1Y1UH65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_626030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871439.1">
        <property type="nucleotide sequence ID" value="XM_022015864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH65"/>
    <dbReference type="STRING" id="4999.A0A1Y1UH65"/>
    <dbReference type="GeneID" id="33557673"/>
    <dbReference type="InParanoid" id="A0A1Y1UH65"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="997" mass="108945" checksum="BD81BD2C91DA3F83" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UH89</accession>
    <name>A0A1Y1UH89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_473245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870925.1">
        <property type="nucleotide sequence ID" value="XM_022012884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UH89"/>
    <dbReference type="GeneID" id="33554692"/>
    <dbReference type="InParanoid" id="A0A1Y1UH89"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX36856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="471" mass="52524" checksum="9E787E8D5004B564" modified="2017-08-30" version="1">MSEHPLSGSPSHLFFSRPLPLDLLPRVALHLANTSQPISQTTLARIARCSKKLYLIAQPLLYSTFYLDDESSAYLLDNFITLDRVYDGGADFPPYMFETFHDLHPIDMPPHLRILYNLWNVRTLVIKTTPYGQGTSHFARMVERLSADHITLLPKLKRIVIARSALERISRAEKVGKRLGSELISSLSLASRPAYLCVDIPSKPPRDFTLDEREPGAGPSFRFLSRSNLIIDISEMKGLKQSTCHLHSDITAPIAIRGALNNLCFEDDYLSEQAFVFNDEDDDGRESDIFLQSAAVKVVEQIRLSITQAIDPRPQVVPIPTWIPTAPTEPPPDDASPLSESRRQWFAQRFPNSVDPAPEAQAAVTGPGTSDPRLSDGPPTTQTIGNTGLTDDDQSTSTEEDDDEPEQDLSGTSFVIWLPGWILVEPIESIIKEWLEERYSCSHDVQTLEQLVTFVSRGSVKAQCGACDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHJ2</accession>
    <name>A0A1Y1UHJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Muconate lactonizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_650107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871517.1">
        <property type="nucleotide sequence ID" value="XM_022018100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHJ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHJ2"/>
    <dbReference type="GeneID" id="33559909"/>
    <dbReference type="InParanoid" id="A0A1Y1UHJ2"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000011">
        <property type="entry name" value="D-galactonate dehydratase family member VSWAT3_13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF6">
        <property type="entry name" value="STARVATION-SENSING PROTEIN RSPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="132"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX37530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="399" mass="44387" checksum="F3C87F2F67D674B6" modified="2017-08-30" version="1">MRPTIITDVQCFLTCPDGIDLVVVKVLTDREVHGWGCATFTQRALAVKTVVDEYLLPLLKGRDANNIEDLWHMLSVNSYWRNGPIGNNAVAGVDMALWDIKGKLAGMPLYQLWGGKSKDAIAVYTHASGNTLDELFASVDSKIAQGHTHIRCQLGIYGGVPKHMHSTKNPTHGAYYDQDEYIENTITMFKALREKYGYRLQFLHDVHERLWASQAIQLAKALEPYRPYWIEDIFSPEQSGWFANLRAQSSVPLAMGELFAHPHEWRDLIVNRQIDFIRCHISDIGGITPALKLGALCETFGVRIGWHGPGDMTGIAVAVNTHLNIFLTNAAVQEYTAAADSTKRVFPNTPEPDNGFIYPGTAPGIGVECDEAVARTFPPLNKVVEWTQSRLPNGALFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UHZ5</accession>
    <name>A0A1Y1UHZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_429065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871195.1">
        <property type="nucleotide sequence ID" value="XM_022012765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UHZ5"/>
    <dbReference type="STRING" id="4999.A0A1Y1UHZ5"/>
    <dbReference type="GeneID" id="33554573"/>
    <dbReference type="InParanoid" id="A0A1Y1UHZ5"/>
    <dbReference type="OrthoDB" id="193860at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="260" mass="29363" checksum="D52BFF51038582A2" modified="2017-08-30" version="1">MTDDLNEELISKTDHSLVVVQTQVDGQKIVVKRSLLVTDTTRERWKSEVETLRLASGHPNVIALLDYDSDLLSLSFKYEHGSSLDQLVDSDQQCQLDSSSVGNLELQTVDALAFLHERSIIHDDIKPQNILWSTQTRKATLIDFGAAMLPPWTFTASGTPNYVSPEFWNRQKDPKNDVWALGITLLFGYRHVPLPDGEWILPHTFEPGPARDGLQSWFNHVAEVRSRAAENGHEVVAWMLEPDIEARPTSKEILARLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIG9</accession>
    <name>A0A1Y1UIG9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_579920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871334.1">
        <property type="nucleotide sequence ID" value="XM_022013415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIG9"/>
    <dbReference type="GeneID" id="33555223"/>
    <dbReference type="InParanoid" id="A0A1Y1UIG9"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF118">
        <property type="entry name" value="BETA-1,2-XYLOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012982698" evidence="1">
        <location>
            <begin position="30"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="350"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX37296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="639" mass="73179" checksum="42E029AE37A6A9D8" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIT6</accession>
    <name>A0A1Y1UIT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="11">PAGM</shortName>
            <ecNumber evidence="4 11">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD324DRAFT_578405</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 11"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871955.1">
        <property type="nucleotide sequence ID" value="XM_022013321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIT6"/>
    <dbReference type="FunCoup" id="A0A1Y1UIT6">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIT6"/>
    <dbReference type="GeneID" id="33555129"/>
    <dbReference type="InParanoid" id="A0A1Y1UIT6"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="18">
        <location>
            <begin position="216"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="17">
        <location>
            <begin position="317"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="15">
        <location>
            <begin position="474"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="394"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="519"/>
            <end position="523"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ORX37968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="559" mass="59400" checksum="ED8A8322E2A1D9AD" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UIZ5</accession>
    <name>A0A1Y1UIZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_624685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000006">
        <property type="protein sequence ID" value="ORX37075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871113.1">
        <property type="nucleotide sequence ID" value="XM_022015725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UIZ5"/>
    <dbReference type="FunCoup" id="A0A1Y1UIZ5">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UIZ5"/>
    <dbReference type="GeneID" id="33557534"/>
    <dbReference type="InParanoid" id="A0A1Y1UIZ5"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX37075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="605" mass="66898" checksum="5A1A5989F0A16689" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJ24</accession>
    <name>A0A1Y1UJ24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_624356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872047.1">
        <property type="nucleotide sequence ID" value="XM_022015690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJ24"/>
    <dbReference type="STRING" id="4999.A0A1Y1UJ24"/>
    <dbReference type="GeneID" id="33557499"/>
    <dbReference type="InParanoid" id="A0A1Y1UJ24"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="337" mass="38031" checksum="DF53ECEB6892EE32" modified="2017-08-30" version="1">MYVWVQCDFILPVGFHRIFKPRTTMTKVIIIGGSGHVGTYLVPRLVKAGYDVTNVSRGTAKPYIDDPAWDKVDHVKLDRKDQDAGEKIAALKPEIIIDMMGYEPDEVERLVDAVRGKIQHYIFCSTVWVGGYATAVPTTEDQMTNPIDSYGEKKLAIERYLWDQVKTHNFPATSFRPGHIVGPWPSINPQGNTNLDIWKILAKGEELELPDHGLGTLHHIHADDCAGLVMAMIENRDKTIGEAFNNVSPQAVSLRWYSEQMFEWLGHQPNISYKPFDQWKQGKPQSDIDATWSHIAHSPCVSVEKAKRVLGFYPRYSSIDAIKESVTALRDSGKLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJD1</accession>
    <name>A0A1Y1UJD1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_622482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871563.1">
        <property type="nucleotide sequence ID" value="XM_022015478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJD1"/>
    <dbReference type="GeneID" id="33557287"/>
    <dbReference type="InParanoid" id="A0A1Y1UJD1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX37576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="70" mass="8263" checksum="988284AC42E4CCB4" modified="2017-08-30" version="1">MESMRNPYLVLLRSMFVCWGCNRTNCQEWRPPINSKSLITFAGIGGRIERHHRRSISQLPPSRDHHRGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UJS1</accession>
    <name>A0A1Y1UJS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872220.1">
        <property type="nucleotide sequence ID" value="XM_022018033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UJS1"/>
    <dbReference type="GeneID" id="33559842"/>
    <dbReference type="InParanoid" id="A0A1Y1UJS1"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008125">
        <property type="entry name" value="Streptothricin_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01754">
        <property type="entry name" value="SACTRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="185" mass="20994" checksum="DB884DEA1AC67A92" modified="2017-08-30" version="1">MEVHIERVSSLVGFDLDLIDHTFDISARVAEPYDESLSCTLIRTEPVSPQRIKTYPREDEDSIKGSDLASSLILVDLDTDGHLRGYLRASKAWNNMVFLDEIIIDRPCRQLGIARLLMASLQAWTIQVGLSAIKVETQDTNVGANSFYRSLAFSFGGYDKFMYYGIEACRDETALYWYWFSQSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKL0</accession>
    <name>A0A1Y1UKL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_621277</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872461.1">
        <property type="nucleotide sequence ID" value="XM_022015369.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UKL0">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UKL0"/>
    <dbReference type="GeneID" id="33557178"/>
    <dbReference type="InParanoid" id="A0A1Y1UKL0"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="151"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="151"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX38539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1893" mass="214875" checksum="10235C10B27EFD03" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKL9</accession>
    <name>A0A1Y1UKL9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_390940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871662.1">
        <property type="nucleotide sequence ID" value="XM_022012661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKL9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UKL9"/>
    <dbReference type="GeneID" id="33554469"/>
    <dbReference type="InParanoid" id="A0A1Y1UKL9"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="137"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX37675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="595" mass="66454" checksum="4CEABA49BB6DEF14" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UKQ1</accession>
    <name>A0A1Y1UKQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_372473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872553.1">
        <property type="nucleotide sequence ID" value="XM_022012612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UKQ1"/>
    <dbReference type="GeneID" id="33554420"/>
    <dbReference type="InParanoid" id="A0A1Y1UKQ1"/>
    <dbReference type="OrthoDB" id="10647133at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="313" mass="34238" checksum="BBCBD2C7C3BED6F7" modified="2017-08-30" version="1">MSSLVASTANMNINDLEMDDYDSESEYVPSDPPSPSALSYDSSADTTFDDDAEDESDDDEENNDDMGASKYHCPPLTLSAMVVEANKDESGFPTLSNPLAENLMADALSRLAAPHADRAAILQGMIKTFTNDPDTIQMYLNAGLVDDNIARSIADKYAESLEEQRMKDLRANPDFDAYKEAVQNAFTRPINTAEEKKALLQTLAQYIDTYAYVVPRGSSYPLRAKALEGLAAIGEQTLNAPVPVRDLIIGSTAVGAKLGLAIKKLVNEAGFPEERKKHRGYIKRTGLAARFRVIMDAWNTVNIHSAGLNDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UL82</accession>
    <name>A0A1Y1UL82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proteasome complex subunit Rpn13 ubiquitin receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_595966</name>
        <name evidence="10" type="ORF">BD324DRAFT_623597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000034">
        <property type="protein sequence ID" value="ORX33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867603.1">
        <property type="nucleotide sequence ID" value="XM_022013851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UL82"/>
    <dbReference type="FunCoup" id="A0A1Y1UL82">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UL82"/>
    <dbReference type="GeneID" id="33555659"/>
    <dbReference type="InParanoid" id="A0A1Y1UL82"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="198"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX37865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="315" mass="34097" checksum="FC29B415D188D1D6" modified="2017-08-30" version="1">MPPIVSIPAGRSLRRHQHDKWVDASPDKGLIEMYVEDDLMHFAWKNRQNGLTENDLIIFPGEATFEKVPQDPSGRTCILKFSSSDQKYFFWFQRRSTESDVRDEVDINELLQDPSYQPGSAPLPDRPTTSAPAQEERSHPPTPGAPRLSNREPGPPIPSSQPVAQASGSSAPASASGATATNEEMARLLVEWAQNGGLGEAQEDARLTDVLSPANISSLLSSNPRLATTLAPLLPSGLNLPSEPKASDLTPILTAPQFTDAIASLDNALRSGGLPGGMMRDLGLPESAGQGVRQFLDALRGLERKEGEDDRMQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULB3</accession>
    <name>A0A1Y1ULB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_578278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872216.1">
        <property type="nucleotide sequence ID" value="XM_022013313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULB3"/>
    <dbReference type="STRING" id="4999.A0A1Y1ULB3"/>
    <dbReference type="GeneID" id="33555121"/>
    <dbReference type="InParanoid" id="A0A1Y1ULB3"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="7">
        <location>
            <begin position="113"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="364" mass="40257" checksum="061B23A9A46B9FFE" modified="2017-08-30" version="1">MAASSQFGFRSLISSTASCSKLISPRNPRSNTRARPFQTASHDLAFARPSTRTYSTAESSPSCSTSGFNTILPPIRYHIFQNPLPYTIGLRLQNELVAKRIEWKRKKGGGRGTGILTILKYLEHVPTYTTGRRDNSPNPDTLHPEEKKVQHVGAEFHITKRGGQVTYHGPGQLVGYPLFDLNAMEMPTRCYVDYLQSLLADYVRSKGIEGVVAPHPEGHVGIFASPTEKVGSIGIHLQHRITSHGFAMNITPEPLAWFDLVLACGLADVKAVSLHDLMVRSAVNDGVLPNPTPGVKDVASELVQRFSEKFSRPLLDLRERSRNKGAKVYREMIGRAEDEAKQFNVEAGGWPSEPDLSRQRELGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULC1</accession>
    <name>A0A1Y1ULC1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Saccharopine dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_641521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872208.1">
        <property type="nucleotide sequence ID" value="XM_022017425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULC1"/>
    <dbReference type="FunCoup" id="A0A1Y1ULC1">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULC1"/>
    <dbReference type="GeneID" id="33559234"/>
    <dbReference type="InParanoid" id="A0A1Y1ULC1"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="8">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX38286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="762" mass="84482" checksum="6A9BA1C8EFCAF77A" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULE2</accession>
    <name>A0A1Y1ULE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mg-dependent DNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_645413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX37935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021871922.1">
        <property type="nucleotide sequence ID" value="XM_022017611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULE2"/>
    <dbReference type="FunCoup" id="A0A1Y1ULE2">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULE2"/>
    <dbReference type="GeneID" id="33559420"/>
    <dbReference type="InParanoid" id="A0A1Y1ULE2"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX37935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33823" checksum="C2B46B5D5E959A95" modified="2017-08-30" version="1">MASRYIDIAVNLTDPQWSGSYHGKQRHPSDIEQVLSRAKRAGVQRILITGTSLEESKIALELAKKFSLHCTAGCHPTQTNELDQFEAGPSGYIDGLRALIETDQAEGGSKRIVSVGEIGLDYDRLHFCSKETQQKHLPALLGLGKQFRLPMFLHSRTSEAHHDFVKILREAGWGTKGESWAGGVVHSFTGTKEEVEELVDMGLYIGINGCSLKTEQNLEVVKHIPIDRLLLETDSPWCSITSTHASYALFPEGLPQISDHGIKGRMEPAEVVVIAHLVAKLKGMDVEELSRIVWDNTMRLFPGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULE7</accession>
    <name>A0A1Y1ULE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_617632</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872734.1">
        <property type="nucleotide sequence ID" value="XM_022014940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULE7"/>
    <dbReference type="FunCoup" id="A0A1Y1ULE7">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULE7"/>
    <dbReference type="GeneID" id="33556748"/>
    <dbReference type="InParanoid" id="A0A1Y1ULE7"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="14">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="320"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX38871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65449" checksum="081FBBF2BE3442FA" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULF9</accession>
    <name>A0A1Y1ULF9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_648990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872746.1">
        <property type="nucleotide sequence ID" value="XM_022017914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULF9"/>
    <dbReference type="GeneID" id="33559723"/>
    <dbReference type="InParanoid" id="A0A1Y1ULF9"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="153" mass="16588" checksum="35E81B643C3A41A4" modified="2017-08-30" version="1">MPSRLSKRARNDPRSESPLTPVPEEDPQPQDTPKHAPESPLDAKIEDPAQETVPAPEQPEAAGQAEITENIQSEAVKARLALRCQAENKACLTAGQETRDKWASKHCSKGSSKCSHCVGVGQPSSFVPKARSSRMATRYSPGDKQEMVSLAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULI3</accession>
    <name>A0A1Y1ULI3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872776.1">
        <property type="nucleotide sequence ID" value="XM_022017919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULI3"/>
    <dbReference type="GeneID" id="33559728"/>
    <dbReference type="InParanoid" id="A0A1Y1ULI3"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX38913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="405" mass="44408" checksum="19E7A9CFFC6233A9" modified="2017-08-30" version="1">MSSVFDDFSSGSAQAAPSRSSTSNSASLDPLLLTPPTDQLGESWWSISSGSSHLRRSEPDFSFHPGDFGGYDDTTCGLVTPITANQSAVDELTPTATHHVPQDDTDVPISSSPLTRCPAVPLGLYLEALSGTDARSDTSESTTFDDTGAIFMKTRTEFRAKWAKIHPVDLARMGDSEAINMRESQGPRIYEVDAKGQQAPTGPDGVDDDEFYLNGPPLRTWQIRAPVAKQIRVDGKAETVYENSTVAIYALDRVFLPSTECLCGSPKMLPVEFDEQEPMTVPPVNSADWWSIDLSSPCLPEIGPLSTGEEIPDDISIFDLDEEFAIGNEDKDKLVIAAMQTREDDAKSMFAAVRDKKGKVEDALKVRGQREPQLHSEGLDPPFPVWWVRKTWSDVKEVCKLVYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULP6</accession>
    <name>A0A1Y1ULP6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_641275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872841.1">
        <property type="nucleotide sequence ID" value="XM_022017412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULP6"/>
    <dbReference type="FunCoup" id="A0A1Y1ULP6">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULP6"/>
    <dbReference type="GeneID" id="33559221"/>
    <dbReference type="InParanoid" id="A0A1Y1ULP6"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF55">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013118732" evidence="2">
        <location>
            <begin position="17"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="551" mass="59496" checksum="818BEA253FF38B3D" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULQ8</accession>
    <name>A0A1Y1ULQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_624327</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="NBSH01000005">
        <property type="protein sequence ID" value="ORX38055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872042.1">
        <property type="nucleotide sequence ID" value="XM_022015686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1ULQ8"/>
    <dbReference type="FunCoup" id="A0A1Y1ULQ8">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULQ8"/>
    <dbReference type="GeneID" id="33557495"/>
    <dbReference type="InParanoid" id="A0A1Y1ULQ8"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX38055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="347" mass="38679" checksum="6D471C4D0FD85CE6" modified="2017-08-30" version="1">MSQQANRHTGAGSSAKGGNMSRSHMEKERLARVESGANKTSSSNSLTPIKAYLVLYNLISTLLWGYILVLTITHFTAVPPSERHAKRGPLSLSRILQTTTATLPHTVSGYIARLSNAGSDRHLKEWTIWVQTLAALEVVHALLGWVRSGVGITAAQVASRLWTVWVVMARSPKVAENPLFSTMVFAWSLAEVIRYSFYATQLLGFRIPGHNYLRYTLFIVLYPLGASSEALLSFSTLPPLFTCPLIPNWVKELSPMGYIYSRLPTSLATRALKSPLGRRLIWNMAKAKTKAKVFGTAQWGTLDYACLVLFFVWWPSLYVLMSHMFVQRRKVLGPGRRVGEPVKVKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1ULR3</accession>
    <name>A0A1Y1ULR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_617907</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872795.1">
        <property type="nucleotide sequence ID" value="XM_022014964.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1ULR3">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1ULR3"/>
    <dbReference type="GeneID" id="33556772"/>
    <dbReference type="InParanoid" id="A0A1Y1ULR3"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="852"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="961"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1207"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1249"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1300"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1351"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1393"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="543"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX38932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1475" mass="164442" checksum="E06968A89A3CD2AB" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UM70</accession>
    <name>A0A1Y1UM70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_621453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000004">
        <property type="protein sequence ID" value="ORX38576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872498.1">
        <property type="nucleotide sequence ID" value="XM_022015382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UM70"/>
    <dbReference type="GeneID" id="33557191"/>
    <dbReference type="InParanoid" id="A0A1Y1UM70"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="420"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX38576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="529" mass="58890" checksum="6968E5729D9F0271" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMC3</accession>
    <name>A0A1Y1UMC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1746 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_618685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873022.1">
        <property type="nucleotide sequence ID" value="XM_022015066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMC3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMC3"/>
    <dbReference type="GeneID" id="33556874"/>
    <dbReference type="InParanoid" id="A0A1Y1UMC3"/>
    <dbReference type="OrthoDB" id="2595285at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013715">
        <property type="entry name" value="DUF1746"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08508">
        <property type="entry name" value="DUF1746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1746" evidence="3">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="349" mass="37635" checksum="0B7DF2B5C235F328" modified="2017-08-30" version="1">MVYGPQRRHAVASLGSAIQTISLAQHLLTPSILILVARLLVQGQIAAASVIHPTRSLLSLFFVVTLLNMAAILLHMLDFASGGNGTKGMLLDFVGQARQASFTRILLMDLTLYILQLSALVVSYVNHQIHAHPDEMKITALPYDDLLLPNAQAMDLDEPEFDLESGLRKRRKGQRDGAEEIWLDDGDDANDEHTMSDRKRLLSSTSSPSSSASRIREPPLIFSLTLPHILNLVFRLPPPPQPRPSFAGGTPAPSPRTATRSLRSLSTSAPQPASSTRTLGAGASPVTPPARPRGSNEEPDGEETEDEQGDESPTQLGRSPRGAASLVPDVGRIPGDYWVDSDRSRGNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMG3</accession>
    <name>A0A1Y1UMG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_618957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873106.1">
        <property type="nucleotide sequence ID" value="XM_022015103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMG3"/>
    <dbReference type="FunCoup" id="A0A1Y1UMG3">
        <property type="interactions" value="567"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMG3"/>
    <dbReference type="GeneID" id="33556911"/>
    <dbReference type="InParanoid" id="A0A1Y1UMG3"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000605">
        <property type="entry name" value="Splicing factor U2AF 65 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000074">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="164"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="268"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="385"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX39243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="526" mass="56003" checksum="99DF9E5A17BC5A4B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMP9</accession>
    <name>A0A1Y1UMP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Snare-complex protein syntaxin-18 N-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_619270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873193.1">
        <property type="nucleotide sequence ID" value="XM_022015155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UMP9">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UMP9"/>
    <dbReference type="GeneID" id="33556963"/>
    <dbReference type="InParanoid" id="A0A1Y1UMP9"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000069">
        <property type="entry name" value="Related to syntaxin 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX39330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="381" mass="42652" checksum="F595C8FA43A39287" modified="2017-08-30" version="1">MVSVDLTQSFKDLVAERKTSYPPSKRSKSPFRSKSPNRKGKGKQVEEDEEFLKEAYRIHTHLGSLSTLLKTIRKPYLSISSAPSRLNRASRQDVSESSELNSLDKWRDSKHLTDRERDEIDLRGRMILRRCKDRVVALEDMEKARQKAILPKPVSSLYTLLPSLAPADGDSAIIQNLVTAHRANIIWTLNDLLAKLSAGLTDLQEERSKRREERTRTLGGQAAKEAAAIEAKSKFSLFAPTSVPSSSSLSNGPALPDVLKGVIPDDEPPIESQLTPEQLQLFSNENNTLLEHMQSQLDSVLSAEKSLLEISALQTELVKHLMTQTEITDRLYDEAVGSVGDVGKANEQLKKARQRNQEGRLFLLVFLFGASMALLFLDWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMT5</accession>
    <name>A0A1Y1UMT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_649444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873231.1">
        <property type="nucleotide sequence ID" value="XM_022017989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMT5"/>
    <dbReference type="GeneID" id="33559798"/>
    <dbReference type="InParanoid" id="A0A1Y1UMT5"/>
    <dbReference type="OrthoDB" id="3364141at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="359" mass="39752" checksum="07591A5317C1BC6C" modified="2017-08-30" version="1">MYSSPPPSSPFAFSPPGSSTRKRAAETEPLEPHNDKKRRPNLANGFSGLSISPRLNRSVSPIPSYEESEATKHEVDEDDGRNLKPVGFDYEDDKRDVRVEELPERSTSEWTRDSTTSSSTSSREADDSDTTFRPIQRTKRRYARVAQQADSVEQPDDAVDPTGQDLHVVDMDPSQDMGSARRKRRRKHRDGVMDMDSDDEPPPSRSRRKTKWHEPEKDRIIITSLGSSDSEVSPESTPSPETRRRYLSQPGAQGFTLSPSLLTHLLNSSQSLPRPPAEKGLVLYRSMPIPSDQIVNEWHGHPNIGHENDSLRFEEIDDDEIAETGDVTMEGSNGGGGGNAGIGSGSTVTEAADEAMEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UMX2</accession>
    <name>A0A1Y1UMX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_619602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873271.1">
        <property type="nucleotide sequence ID" value="XM_022015185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UMX2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UMX2"/>
    <dbReference type="GeneID" id="33556993"/>
    <dbReference type="InParanoid" id="A0A1Y1UMX2"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX39408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="308" mass="34218" checksum="A794D1AA2F62307B" modified="2017-08-30" version="1">MSDQKKIFVFTATGDQGSSVAKYLAKTGQYEIWGLTRNTESDKAKELTQLGVKMVKGDMDDVSSYEPHLEGIHGAFVNADFWAKYFSNGFNGKEAGEYEYGVATRAIEAVVKAGAKHIIYSSLDDCPFVPHFHYKQEVSKWAKSKDYPVTNLHVAHYLSNLVKFPDFIKADGEGGYILQIAAADETTLGNFAVEQTGGWVVPIFADSKKYLGGKVNATSETLTVKEWAKEISEYIGKPVKTMGLTPAIYDDYSGLVKNGVPEELVLNYKGFNEGYFKWNLKESLEVFPDAWDTKAWAKNTGALDQFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UN66</accession>
    <name>A0A1Y1UN66_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_617990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872820.1">
        <property type="nucleotide sequence ID" value="XM_022014977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UN66"/>
    <dbReference type="GeneID" id="33556785"/>
    <dbReference type="InParanoid" id="A0A1Y1UN66"/>
    <dbReference type="OrthoDB" id="6576058at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="2">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="157" mass="16708" checksum="BF4B94BC1CD22F8E" modified="2017-08-30" version="1">MHFLSLALLPFALALPAQVPMIVRDIIDVDFDSCSASNSVLNITISPCEVGNGSRDDPCHFSAGSNYTITLTYVPPSNSSAPRANLAAEDPAGSGYAYSGQSFGACEYTACPIEENVISTYTYKFVTLDSPFNRLTFNTTDGLEGPSLMCASFPVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNM4</accession>
    <name>A0A1Y1UNM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_618589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX39127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872990.1">
        <property type="nucleotide sequence ID" value="XM_022015053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNM4"/>
    <dbReference type="FunCoup" id="A0A1Y1UNM4">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNM4"/>
    <dbReference type="GeneID" id="33556861"/>
    <dbReference type="InParanoid" id="A0A1Y1UNM4"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="186"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="416"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX39127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="546" mass="59001" checksum="84A6267FD7A04823" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UNU8</accession>
    <name>A0A1Y1UNU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_655212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000003">
        <property type="protein sequence ID" value="ORX38805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021872668.1">
        <property type="nucleotide sequence ID" value="XM_022018809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UNU8"/>
    <dbReference type="FunCoup" id="A0A1Y1UNU8">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UNU8"/>
    <dbReference type="GeneID" id="33560618"/>
    <dbReference type="InParanoid" id="A0A1Y1UNU8"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX38805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="79769" checksum="774C24A1D65854AA" modified="2017-08-30" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UP41</accession>
    <name>A0A1Y1UP41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873595.1">
        <property type="nucleotide sequence ID" value="XM_022014679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UP41"/>
    <dbReference type="STRING" id="4999.A0A1Y1UP41"/>
    <dbReference type="GeneID" id="33556487"/>
    <dbReference type="InParanoid" id="A0A1Y1UP41"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="305" mass="33905" checksum="5E688A339E0D8139" modified="2017-08-30" version="1">MKVAVTGASGLLGRAVFQYFEQQGADVIRLAYSRASDGYTKLDLLDQKAVEDFFNGHQVDVVVHCAAERRPDVVEADPAKAEQTNVAVPRQLAQLASKQGFRLFYISTDYVFNGTKPPYEVNDEPDPLQSYGQQKRAGEVAVLAERESGAQSTVLRVPILYGKTTYNAESAVNIIVDVVLDQSGKEYKMDDRQVRFPTNVEDIARVLYDLSKLDKSLPPILHYASPAPALTKYNMTEIIGKHLGVSIDHVKADKEKPVVKPGQTQRPENTQLSTKALVDIGIDTREDKSFDDWWKAYAGELKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UPH6</accession>
    <name>A0A1Y1UPH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_246136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873745.1">
        <property type="nucleotide sequence ID" value="XM_022012269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UPH6"/>
    <dbReference type="FunCoup" id="A0A1Y1UPH6">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UPH6"/>
    <dbReference type="GeneID" id="33554077"/>
    <dbReference type="InParanoid" id="A0A1Y1UPH6"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX39960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="671" mass="71699" checksum="92790631ABF9BE08" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ81</accession>
    <name>A0A1Y1UQ81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_576165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873944.1">
        <property type="nucleotide sequence ID" value="XM_022013176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ81"/>
    <dbReference type="FunCoup" id="A0A1Y1UQ81">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UQ81"/>
    <dbReference type="GeneID" id="33554984"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ81"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000003">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="9">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX40159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="242" mass="27929" checksum="E4DE2B642014D021" modified="2017-08-30" version="1">MERPSFQIIKCVWRFRSRCEAVTDTVFFQNRAGANKGSGGVAGAAETAIDRRERLRKLALETIDLAKDPYILRTHLGTLECRLCLTLHVNEGSYLAHTQGKKHQTNLARRAARENKDLELQTQVPQAPTIRKKVFVKIGRPGYKIIKIREPTNQRMGLLFTVSLPEIKAGERPRRRFMSAFEQRREIPNRALQYLVLAAEPYETIAFAIPAKEMVEQEEDPESVWEHWDADEKVYSCQFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQ90</accession>
    <name>A0A1Y1UQ90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_648793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873978.1">
        <property type="nucleotide sequence ID" value="XM_022017885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UQ90"/>
    <dbReference type="STRING" id="4999.A0A1Y1UQ90"/>
    <dbReference type="GeneID" id="33559694"/>
    <dbReference type="InParanoid" id="A0A1Y1UQ90"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001062">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000747">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="728"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="501"/>
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            <end position="532"/>
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        <location>
            <begin position="566"/>
            <end position="587"/>
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    </feature>
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        <location>
            <begin position="805"/>
            <end position="816"/>
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    </feature>
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        <location>
            <begin position="836"/>
            <end position="845"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX40193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1100" mass="119116" checksum="3D367FF6B962CAF4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UQE7</accession>
    <name>A0A1Y1UQE7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_616940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874004.1">
        <property type="nucleotide sequence ID" value="XM_022014866.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000193218">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tma16_sf"/>
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    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40219.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22827" checksum="5D1F91024C5BA15F" modified="2017-08-30" version="1">MPGNRRLTKKTIKGKDNLHPSSRKAGQLQRVHLRAAKLDHRAKIRQSISSQKLERPLFFLHSLPSSHPLSLPALRELITDVYLARHDARISELEGQRRSGRPKDKELIDLEEIKKREQAEWETGIEVPDLTHGPTVKILFGLQDSSTSLQQSHLDLLRHIRLFKDDPDTVLVTREGKWDKMGFGVEEGQEPRGSDVVMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR15</accession>
    <name>A0A1Y1UR15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_611003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874172.1">
        <property type="nucleotide sequence ID" value="XM_022014232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR15"/>
    <dbReference type="FunCoup" id="A0A1Y1UR15">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UR15"/>
    <dbReference type="GeneID" id="33556040"/>
    <dbReference type="InParanoid" id="A0A1Y1UR15"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33505" checksum="C774C9ADA4E20ACD" modified="2017-08-30" version="1">MQPMKRKTPSGHSPSPAPGSGKPFVKPEPVEHEVKKQRFTAGPSFQSGPGTGSSVNALGTAVMQMSAHLKAVGTLGYQDAYFHAQAEFPSHDPVKVLEMLKRLERVIFNDVNQVFSYNPELTLANEAQIRGYIRTNSTPTQPVLLRSIREALPPNGTSIIEDLERRGEIQVMRSLTGQFKDPPLPRLGRKNILGLKINDSGNGGSRMRSLWWDDLRERDRAGKRADDDFIFAWDDVVITEADDIVRLLEKENLGAGSAMPAAPKIVAQAPAKKKKTRRGPLKISNVHMKEQGIDFSKDYEGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UR89</accession>
    <name>A0A1Y1UR89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_611401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874262.1">
        <property type="nucleotide sequence ID" value="XM_022014262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UR89"/>
    <dbReference type="STRING" id="4999.A0A1Y1UR89"/>
    <dbReference type="GeneID" id="33556070"/>
    <dbReference type="InParanoid" id="A0A1Y1UR89"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="315" mass="33467" checksum="CAB8AF186DB635E5" modified="2017-08-30" version="1">MESPGSQASSSLSSGNVLTASHPSTSASGGKPDRLFVGNLSPTVDEYTLIQVFSKYGKITKLDFMFHKSGVLKGKPRGYAFLEFSNKDDALRAMVKLHDRLLRGRKLVVTYANSAPINDLPLITKGRRPTDAPKTTTLSLLKSNRRPQNAAAQIAAMEAKLATMAKTKPADEDYVPGFNQYPLGHAIAGSASPHSGTEIMEEDAIGEVAGMLAADDLQRELEAELNTQPPCSGSTDDPRSSQSPRSPAHDQRSTQSPAPPATQPAMPKLVPGAGLPSRPPTISNATASASNVNRSQARSEEIKRGLAGLPKKPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URC9</accession>
    <name>A0A1Y1URC9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_611555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874300.1">
        <property type="nucleotide sequence ID" value="XM_022014279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URC9"/>
    <dbReference type="STRING" id="4999.A0A1Y1URC9"/>
    <dbReference type="GeneID" id="33556087"/>
    <dbReference type="InParanoid" id="A0A1Y1URC9"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="211"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX40621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="306" mass="34778" checksum="EB8FB25A11C63F43" modified="2017-08-30" version="1">MDRDASPPRRRARRSASPPQRNFEHQGGGRSSSRNRSPGHYVKDSRDREPRRSGGGSGEFRDAGYGNHSRGSYEDSRSGRDPGHRHGRSRDDGYGDRSRPRDNGYGDRNGGSRRRDGDYTAQDRERERASDRSKYELEATGEDKEKALIEASKPNFSNSGLLAKETNTVKGVELKYNEPPEARKPLKNWRLYVFKGKEQLDLIHIYRQSAYLVGRDQVVTDIPISHPSCSKQHAAIQFRQITEKNEYGDVTSSVKPFIIDLDSTNGTHVNDQEIPKSRYYELRNSDVIKFGTSSREYVLLHEDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URJ2</accession>
    <name>A0A1Y1URJ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_576439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874012.1">
        <property type="nucleotide sequence ID" value="XM_022013188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URJ2"/>
    <dbReference type="FunCoup" id="A0A1Y1URJ2">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URJ2"/>
    <dbReference type="GeneID" id="33554996"/>
    <dbReference type="InParanoid" id="A0A1Y1URJ2"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="127"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX40227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="532" mass="60491" checksum="E633680D8EE97491" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URQ4</accession>
    <name>A0A1Y1URQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_615145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX39825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021873610.1">
        <property type="nucleotide sequence ID" value="XM_022014687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URQ4"/>
    <dbReference type="GeneID" id="33556495"/>
    <dbReference type="InParanoid" id="A0A1Y1URQ4"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX39825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="211" mass="23037" checksum="F8D8E37B126AAEF5" modified="2017-08-30" version="1">MAPNAPRTHSTTYTDVFDLAVATKCFVDNWGILTGMNQAWILAHDESRNGSAGDDDEDPRQSKSVGEITDTLLSIPEESKKELSPILRDSAARFAYSGAPTADQLNLLLCSFNDFQDGPTNSRELTGQERTLFTKMRACLSVHAKLLEGKPKLPSFLQTYNKSITNESEHFKCRCSAFSDSTNATLETMRMADGNLDEVSSTGDLAASGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1URZ5</accession>
    <name>A0A1Y1URZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 10">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_617136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 10"/>
    <dbReference type="EMBL" id="NBSH01000002">
        <property type="protein sequence ID" value="ORX40274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874059.1">
        <property type="nucleotide sequence ID" value="XM_022014886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1URZ5"/>
    <dbReference type="FunCoup" id="A0A1Y1URZ5">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1URZ5"/>
    <dbReference type="GeneID" id="33556694"/>
    <dbReference type="InParanoid" id="A0A1Y1URZ5"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="12">
        <location>
            <begin position="269"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX40274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="596" mass="63895" checksum="E184A8AE1C5784D1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USM5</accession>
    <name>A0A1Y1USM5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytoplasm protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_574604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874697.1">
        <property type="nucleotide sequence ID" value="XM_022013070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USM5"/>
    <dbReference type="FunCoup" id="A0A1Y1USM5">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USM5"/>
    <dbReference type="GeneID" id="33554878"/>
    <dbReference type="InParanoid" id="A0A1Y1USM5"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000036">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX41018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="591" mass="66285" checksum="1786D5C50E15E5B4" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USV4</accession>
    <name>A0A1Y1USV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_611851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874396.1">
        <property type="nucleotide sequence ID" value="XM_022014319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USV4"/>
    <dbReference type="FunCoup" id="A0A1Y1USV4">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USV4"/>
    <dbReference type="GeneID" id="33556127"/>
    <dbReference type="InParanoid" id="A0A1Y1USV4"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX40717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="238" mass="25564" checksum="771E60D943E567AA" modified="2017-08-30" version="1">MAPPKRALIAISSAHAPLYPDGKETGLFITEALHPYEVFEKAGFEVDLASETGTYSPDWLSTTEDWLKPDERKIYEDHSSGFRSKLDKLHKASDLNSKDYGIFFASAGHASLIDYPDAKDLQKIASDIWAEGGVVSAVCHGGAIFKGIKDKDGKPIIAGKNVTGFTTKGEEEEGVLDTIKSWNRPTIEASAKDLGANYVSPAGPWDDFTQTDGNLVTGANPASATSTAKAAVAVWEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1USZ5</accession>
    <name>A0A1Y1USZ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_678522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874817.1">
        <property type="nucleotide sequence ID" value="XM_022019002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1USZ5"/>
    <dbReference type="FunCoup" id="A0A1Y1USZ5">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1USZ5"/>
    <dbReference type="GeneID" id="33560811"/>
    <dbReference type="InParanoid" id="A0A1Y1USZ5"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012621077" evidence="9">
        <location>
            <begin position="26"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="83"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="724"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX41138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="880" mass="94889" checksum="DB6BE022AC286757" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTA8</accession>
    <name>A0A1Y1UTA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FK506-binding protein</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_612042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874443.1">
        <property type="nucleotide sequence ID" value="XM_022014338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTA8"/>
    <dbReference type="FunCoup" id="A0A1Y1UTA8">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTA8"/>
    <dbReference type="GeneID" id="33556146"/>
    <dbReference type="InParanoid" id="A0A1Y1UTA8"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="357"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX40764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="443" mass="48203" checksum="75DF3DC8D4E06BA6" modified="2017-08-30" version="1">MAVKRSLWSLTLLPGERTPLFVQRDFVLTNAALGEELRSETGRSIVKVTHQPIPASLFNDDSESDEDEDEDEEESEDEFELDEVEGFKLTPKKGKANGAAAEDEEEEDDEEEDNEEEEDDEVDGELSEDSEMDSDYSDSEEGLEQTNVLCSLLAGRVEQATLNLTFCEGDVVVFEVTGENSVHLMGNYVIQPEPDLSDSEIDSEYDSDELYDGPDDFDELYGSEDEDMEDEPEATIEEIVEKVVEKPSKKVAAAKEEKPKAKAVEATETKKRKAEEIESPAPKAATTTPAASTEGLSKAQKKKLAKKAKLEGATAAAPTPAAAAPTANGNANKKRTLPSGLIIEDIKNGDGPVAKAGKRLGMRYIGKLENGKQFDSNTAGKPFTFVLGRNEVIKGWEEGLKGMAVGGERRLTIPPAMAYGSQKLPGIPKNSTLKFDVKLVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTB6</accession>
    <name>A0A1Y1UTB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_613575</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874871.1">
        <property type="nucleotide sequence ID" value="XM_022014511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTB6"/>
    <dbReference type="FunCoup" id="A0A1Y1UTB6">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UTB6"/>
    <dbReference type="GeneID" id="33556319"/>
    <dbReference type="InParanoid" id="A0A1Y1UTB6"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="21">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX41192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="176" mass="19413" checksum="06BF169C3B0ED16A" modified="2017-08-30" version="1">MSTTAKRRLIRDFKRLASDPPVGISGSPNPDNIMIWNAVIFGPPDTPFEDGSFRLTLTFSDSYPNKPPTVRFVSKMFHPNIYSNGELCLDILQNRWSPTYDVAAVLTSVQSLLNDPNPQSPANVEAAQLYKDNIKEYERRVKTTVEASWMDPNETIEEAPAAGSSATAQPAPVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTP9</accession>
    <name>A0A1Y1UTP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_612783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874666.1">
        <property type="nucleotide sequence ID" value="XM_022014442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTP9"/>
    <dbReference type="FunCoup" id="A0A1Y1UTP9">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="GeneID" id="33556250"/>
    <dbReference type="InParanoid" id="A0A1Y1UTP9"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX40987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="395" mass="42225" checksum="A4207C43BF3D6CD0" modified="2017-08-30" version="1">MAAEEQSSPKAVFGVVSFYMFSALVMVMVNKWVLNSSSLPLTFLLLQLVISVVCLTLLSFLPPTSRFAFVPPRWNRSIIIAVAPVCTANVVGLAFNIYCLKLVDASFFQVARGLTLPMTVVLQSVMTGERPTWGTVGSCAIVTWGFTHTFLPTPFISSASTIAPSEAQVSSSVLSSSEAPVLGMVFGVLSAAMVAIHAVLIKSALKSVDGKTLDLAYWSNALSALALLPGILVSGELAGLPKLIRGEDGNLGAFALGTLVTGLVGFLICVAGLLSIKVTSPVTHMFSSAVRSVLQTLLGVWLFRDIINASRVMSITLILTGSLLYTWIKSRPKNPQPQAESTPMKDLAEQEGLLESTSQNERTEALLKPVDLESGLGSEARRRSSEPGFEKSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UTT0</accession>
    <name>A0A1Y1UTT0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_647732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874505.1">
        <property type="nucleotide sequence ID" value="XM_022017708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UTT0"/>
    <dbReference type="GeneID" id="33559517"/>
    <dbReference type="InParanoid" id="A0A1Y1UTT0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX40826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="189" mass="19115" checksum="7A3958031ADCFB39" modified="2017-08-30" version="1">MFGASPTLDPMTLQSMGRGGIGMGIQPQAYQQPLAQSTAYGGVGFGLSGMGPMGSTNSVGGGTGMGGIGMPMMGSPMGGMLAMPGMGIGSMGGMSGLAGGMPGMGMNPMAMRAMAMAGGGMGMGMRGALCNGLVSPWLRSRSHRFETIISHSLLDPSALPRRHRGCVRNNNNARRVRTPALRSAAFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UU47</accession>
    <name>A0A1Y1UU47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_606801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874836.1">
        <property type="nucleotide sequence ID" value="XM_022014026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UU47"/>
    <dbReference type="GeneID" id="33555834"/>
    <dbReference type="InParanoid" id="A0A1Y1UU47"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011988063" evidence="8">
        <location>
            <begin position="24"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX41157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="702" mass="75205" checksum="958415E5E8D1E0E9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUK8</accession>
    <name>A0A1Y1UUK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_613868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX41264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874943.1">
        <property type="nucleotide sequence ID" value="XM_022014543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUK8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UUK8"/>
    <dbReference type="GeneID" id="33556351"/>
    <dbReference type="InParanoid" id="A0A1Y1UUK8"/>
    <dbReference type="OrthoDB" id="3632757at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013322236" description="Peptidase M24 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX41264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56469" checksum="BD597C8F49765D03" modified="2017-08-30" version="1">MVSITGWLTICALIASCAAKQPVAQYRPLPPLREQDALENKWVQMRYDRIPEILERHGYDAWILTMREYAEDTAFRALVSSTTQFWGRRRTMWMFHTNPNVTSPFHFVSLKDDLWDGLLDTLEQVNPKKIAINVDEDMAFSDGLHTGEGHKLMSKLGKWADRVTPCRDIGVEVIATRAGGKEQLEMYRLLQENVWAMIQEGFSERVIEIGKTTAEDLMWWFRETMVWKLGSRTWFHPSVEIHRSPDEPAVEDHPAMREGDMLHVDIGIYAMGMNTDTQHLGYILRSNETAPPQSLQDGLAIANKMQDFNRLEMRPGLTGDQVFWAIRGDMTKAKLNEHGRIYSHPIGDYGHSAGAVIGMADWQTSIPGGGENKVLKDYWTSVELAGVNYIPEWRREQNFELEEDVYWCEETDRFEWVFGQQTEFHLVQPKNRKHGHGHQHGHGHKHHDHEHKHAGHGHRHGHKNLGHHTEASWMSRVAAKLGWDIVRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UUW2</accession>
    <name>A0A1Y1UUW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_612818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000001">
        <property type="protein sequence ID" value="ORX40995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021874674.1">
        <property type="nucleotide sequence ID" value="XM_022014446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UUW2"/>
    <dbReference type="FunCoup" id="A0A1Y1UUW2">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UUW2"/>
    <dbReference type="GeneID" id="33556254"/>
    <dbReference type="InParanoid" id="A0A1Y1UUW2"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX40995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="377" mass="40604" checksum="5C94E073B5410126" modified="2017-08-30" version="1">MAQPPYMNSRSPPPLQHPKPTHPAYPPPEPPHTPGTSNNSSPYSQAQRISQDGAGYTRYSSPPVGEHSSAGAATGISASSSGVNGNLYGAPNAQTHPRQGYGASPNPPAMGGYGMNAPQGFGAWAGMNDATAQMGVQFGKSAVAAGQEYVEKNFTRYLPLQLIKISFSVTNSYVLRKLRLILFPWRHSPWARQVKRTGEGGVEGWQPPRDDINAPDLYIPTMALVTYTLLSALASGLQSKFHPEILGFTLSKALAVVIVEFCIIKLGCYLLDVRNSGASGVELIGYGGYKFVGIILTILVGFLNLGRLTSIAVFVYALCANGFFLLRSLKYVLLPDPSSMPAVTAGTLSHSQRSRRVQFLLFVAATQLIWMGWLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U5B1</accession>
    <name>A0A1Y1U5B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma tubulin complex component protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_654315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000038">
        <property type="protein sequence ID" value="ORX33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867597.1">
        <property type="nucleotide sequence ID" value="XM_022018789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U5B1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U5B1"/>
    <dbReference type="GeneID" id="33560598"/>
    <dbReference type="InParanoid" id="A0A1Y1U5B1"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="5">
        <location>
            <begin position="129"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="316" mass="34157" checksum="57E6865A092E932B" modified="2017-08-30" version="1" fragment="single">MGSSRDTGPERALRFGGIWTKLQHGKALQSPLPHVQFLLALSSLEPKQTSSGQPGSFPWAQSAGNSRTALADIPVSENIAQTSTAAGISQLTSGQAGLNGDDRKGKGKSKADILNSWRASQAFSEQLLLRDILYLLQGIDGQFIRFAVRPPEEQNPYKSAKAKAAEGAAFALGKDGEAGTKSEDGEVVGIDINVDEAANGNISKPTRLLLMQIAEMGMLYRQITNYLAVKQTGGSSRGMIEQSLCHFLHHELSDYHRLLAVLETQMNLNLQEASTGPSSDDTNENGRGLTLLRMGLWTEEMKLKMRYLAAVVSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U696</accession>
    <name>A0A1Y1U696_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_214439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000019">
        <property type="protein sequence ID" value="ORX33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867872.1">
        <property type="nucleotide sequence ID" value="XM_022012194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U696"/>
    <dbReference type="FunCoup" id="A0A1Y1U696">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U696"/>
    <dbReference type="GeneID" id="33554002"/>
    <dbReference type="InParanoid" id="A0A1Y1U696"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001752">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123578" checksum="99BA2F58E3152318" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6G0</accession>
    <name>A0A1Y1U6G0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">U4/U6.U5 tri-snRNP-associated protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD324DRAFT_584709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867933.1">
        <property type="nucleotide sequence ID" value="XM_022013700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6G0"/>
    <dbReference type="FunCoup" id="A0A1Y1U6G0">
        <property type="interactions" value="683"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U6G0"/>
    <dbReference type="GeneID" id="33555508"/>
    <dbReference type="InParanoid" id="A0A1Y1U6G0"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="209"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ORX33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62541" checksum="6122F8869CB8C686" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U6K8</accession>
    <name>A0A1Y1U6K8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_653949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021867958.1">
        <property type="nucleotide sequence ID" value="XM_022018730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U6K8"/>
    <dbReference type="GeneID" id="33560539"/>
    <dbReference type="InParanoid" id="A0A1Y1U6K8"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX33648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="140" mass="13447" checksum="3490429429B7D7C8" modified="2017-08-30" version="1">MAPFPTGHVILRQFGDVGGSLGGVANTIGNGAAGAVETVADGAGGAVNTAVETAGGAVQTAAGAVGGAANTVAGAVQTGAGPVGSIADDVSQVGALVGPLKAAMDFWKNNKQDIYIGKSCAGRQVDFAQAPSSSLSFYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7F9</accession>
    <name>A0A1Y1U7F9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_643649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868240.1">
        <property type="nucleotide sequence ID" value="XM_022017562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7F9"/>
    <dbReference type="STRING" id="4999.A0A1Y1U7F9"/>
    <dbReference type="GeneID" id="33559371"/>
    <dbReference type="InParanoid" id="A0A1Y1U7F9"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Midasin AAA lid" evidence="10">
        <location>
            <begin position="106"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="9">
        <location>
            <begin position="239"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Midasin AAA lid" evidence="11">
        <location>
            <begin position="387"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="490" mass="55059" checksum="66C1586B638B63E4" modified="2017-08-30" version="1">MEGALSKALRAGRWIVFDDIDRASMEMLVLIADVLEALNSILSGDLVLTSRGDVEAIPRHPNFRLFACMNPATDVGKKDLPPHLSVLFTRIHVPPPDDNREALVAIIEQYLDGPLVLDVADLYTDFKKQATAREIVDGSLAPHYSMRTLTRALSFAVNTPLNLRRAVAEGWMMAFMMALDPPSIARVQPLLERHLGTHPAASFSIPPGPLPPLPSRLVLTPSVSRKLVDLSRAILARYPVLIQGPTSSGKTSAIEHLARTTGHRFVRINNHEHTDLQEYLGTHMTDQSGNLVFQEGLLVTAVRQGHWIVLDELNLAPTDVLEALNRLLDDNRELLIPETGEIVKPHPQFMLFATQNPPGLYAGRKVLSRAFRNRFLEVHFDDVPNDELETILCERCQIAPSYARKIVQVFEELRHRRQTSRVFESKHSFATLRDLFRWAERGAIGYEQLARDGYMLLAERARNEEDKVVIKEVLEGVMKVALTISQRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7J2</accession>
    <name>A0A1Y1U7J2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_605342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868271.1">
        <property type="nucleotide sequence ID" value="XM_022013999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7J2"/>
    <dbReference type="FunCoup" id="A0A1Y1U7J2">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U7J2"/>
    <dbReference type="GeneID" id="33555807"/>
    <dbReference type="InParanoid" id="A0A1Y1U7J2"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="144"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="442" mass="50053" checksum="0C6BA5A4D8C05E03" modified="2017-08-30" version="1">MRNLVIYLSALTALSSHAYKHEAAQLRDLLAYPKYEIQFLNDLPISWSDADRVEKEGLERAEEWSELRLKERKELGDGSDVPLKDRLEIIPMTFTPAGSDSAAEYLCLLPPKNVTSAQTLRLKSESHEELDPAQSWAAMSHLDGKCLYSTLGWFTYSYCHNSHIRQFRAARHTHPHPPGGYEPEEDTSYEAYTLGQKGSRRPSRAAAESNAVSFGLGASSRYLVQRWSDGTLCDKTKRPREVEVQIHCSMTTTDIIYLVKEMTTCQYVVVIHSPHLCSLPGFRAPQVDVEPAGIQCRQSISDQDFESWFSSPKEEREGRLMLPGDRREAEKVMEEKKMPIDGLASLDDKALMSLFEGAIKALQSDNVADMTDDEEVMYLALVEDAEGNVVIETSNEMNQIKEADKMLEVVKGFLEQKRKPAREEEEEDKDGQQADDHVRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U7U2</accession>
    <name>A0A1Y1U7U2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_653768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868366.1">
        <property type="nucleotide sequence ID" value="XM_022018701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U7U2"/>
    <dbReference type="GeneID" id="33560510"/>
    <dbReference type="InParanoid" id="A0A1Y1U7U2"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="322" mass="36326" checksum="A0E672254E22FB4A" modified="2017-08-30" version="1">MTDSQSSPLLDLNHITPLISYETLTLSTDLDFVELIHHYLTRDDTSDTPSLPRIITLVLNHIPSPLLCNKIGDYTADSGVELLTQCRTVIVTEQALHSLLLSSSEYRCELSTSLEGLSTIASPDRVEVASIDNLLDTRRKRPSRSSWSPTAYELVDKLVSSWLKEALESLVIFGQYHRVHPYIHPNSKKLVKQIVWRGIYDSKLHYSALQASKTPKAPYIPIAPLKPEDDAERKIAWLTAEAYPHVHAFLNQELKRESRRKLVISCPELTPWEMRQVCRSLISEAESMIGGKADGMIGDSSAKTTRRSSRVRVIVDVEARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8I3</accession>
    <name>A0A1Y1U8I3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD324DRAFT_635534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868612.1">
        <property type="nucleotide sequence ID" value="XM_022016816.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1U8I3">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8I3"/>
    <dbReference type="GeneID" id="33558625"/>
    <dbReference type="InParanoid" id="A0A1Y1U8I3"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="623"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="820"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ORX34349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1294" mass="144583" checksum="377ABC66DE2725E6" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U8U2</accession>
    <name>A0A1Y1U8U2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein COX19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_584314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868252.1">
        <property type="nucleotide sequence ID" value="XM_022013678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U8U2"/>
    <dbReference type="FunCoup" id="A0A1Y1U8U2">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U8U2"/>
    <dbReference type="GeneID" id="33555486"/>
    <dbReference type="InParanoid" id="A0A1Y1U8U2"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="116" mass="13022" checksum="80FC9DAF429CD08E" modified="2017-08-30" version="1">MSFGRPGGFADTFKVTPPQRGSFPLDHDGDCKAFMIEHLKCLKEFKGDNGKCRFEARRYLECRMDHDLMDRDDMQNLGLGNATESQTSKAAQVKPQAADVRNGDVKAQPTTVQERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U945</accession>
    <name>A0A1Y1U945_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIP41-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_638079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000016">
        <property type="protein sequence ID" value="ORX34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868314.1">
        <property type="nucleotide sequence ID" value="XM_022017081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U945"/>
    <dbReference type="FunCoup" id="A0A1Y1U945">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U945"/>
    <dbReference type="GeneID" id="33558890"/>
    <dbReference type="InParanoid" id="A0A1Y1U945"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="369" mass="41093" checksum="4D6BF9FCDB4B47FF" modified="2017-08-30" version="1">MADAHPARLQTLPSMPRFTLKKDKYTNRIDVERWSITATKRPILNGKEIDSAEKRFGLPLPEMTFGNNSLVLIYDPTLPSSSSTSTTRSVNTRGSDDNAVSSAGGSSTNQRVVFDAMEALQGVAVGEGWEERVGGGVKVSMADKWSKSRRSPSLLSDTPVPEKPVRPHDWTYSTCYPGSSAPPTTSAFASSSSHSIPLELLARRDPSLDQILYYEDVPLFEDELHDHGGSMLNVRIRVMPHCLFILARLFVRVDNVLFRIHDVRVYHAFGSNEVIREVSGLEADYKEVKARLIKPEDLSPLTDQNWVSETMMSLAAKSVDEQGRPRLRSRITGKPWPGLGRRCEVLRLDSVERDIIQAGDKLSDLKVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9A7</accession>
    <name>A0A1Y1U9A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="4">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_636548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868855.1">
        <property type="nucleotide sequence ID" value="XM_022016907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9A7"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9A7"/>
    <dbReference type="GeneID" id="33558716"/>
    <dbReference type="InParanoid" id="A0A1Y1U9A7"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="332" mass="37088" checksum="4F5F4BA61215E906" modified="2017-08-30" version="1">MLSSPAPPSPALYTIFSTPKDPPAHVAVVFLCGSEVDERSELSETPRRRGRQRHAGMRLRRKAHQYDGALMESVARVISWASLAGISELSIYDNHGVLDDCRDAIVSQYQRLPVSPPDSRSPSPRRSAKSTLAPQNGLGQTSYADVVKKDTVHEPFDPVTSFTVFAPNTKPLHVHLLTSDSREILAHIAREERAASPRETISQQSLDERVRETLQLSCDPELLLVHRIKRPSFLGSLLARAPPELGGFPCWPLRITEIYMHPTPLPIPSMLMDIFSPLLQRSRTSSLSLLRKTAKRFPRLASRESSESGVLHKSEWDGAMKAWQNVEQRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9C6</accession>
    <name>A0A1Y1U9C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_639190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000018">
        <property type="protein sequence ID" value="ORX33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868005.1">
        <property type="nucleotide sequence ID" value="XM_022017200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9C6"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9C6"/>
    <dbReference type="GeneID" id="33559009"/>
    <dbReference type="InParanoid" id="A0A1Y1U9C6"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="383" mass="40948" checksum="8339213F6D504B7B" modified="2017-08-30" version="1">MSGKLAISMLMGQPALMSCTKLVAGRSAMPLFRITYQAPAVSHSAGTSWKRTYATHRDLRTDPSLDASPRVRTGQSNLDGRESVGPFPLGVGPSGRNKTWKSWKELGIKGKLGRTVRQTGNLGVILFGGGLFILLTLSLTTELFARNSPSVLYSQAVDKIRQSDALDAHLLPPLTFTHSPTPAAPVRGSTPVAHTLLRHPSSGRDHMIITFWVHGRGRNEPEPLHWAKSSWHLVLTSLDDAARYLGFIDGGASLFTGSSEDASMGKERNIANVEVDTTQSAEDGSGWLGSLLGGFSGLRNGSNANTRGDRSGTATRGLPPPGTYKVGEVKGDYVKNANGQYQLLSLTIDVPSSSASYPGRAVVFWAPEADREGLISMIGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9G3</accession>
    <name>A0A1Y1U9G3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD324DRAFT_664472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868424.1">
        <property type="nucleotide sequence ID" value="XM_022018907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9G3"/>
    <dbReference type="FunCoup" id="A0A1Y1U9G3">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9G3"/>
    <dbReference type="GeneID" id="33560716"/>
    <dbReference type="InParanoid" id="A0A1Y1U9G3"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="377"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ORX34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="538" mass="59322" checksum="F0885D73F869AEE1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9I1</accession>
    <name>A0A1Y1U9I1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_643241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868914.1">
        <property type="nucleotide sequence ID" value="XM_022017531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9I1"/>
    <dbReference type="STRING" id="4999.A0A1Y1U9I1"/>
    <dbReference type="GeneID" id="33559340"/>
    <dbReference type="InParanoid" id="A0A1Y1U9I1"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="820" mass="91442" checksum="77A70816B17F7FA1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9M9</accession>
    <name>A0A1Y1U9M9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_634762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868983.1">
        <property type="nucleotide sequence ID" value="XM_022016756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1U9M9"/>
    <dbReference type="FunCoup" id="A0A1Y1U9M9">
        <property type="interactions" value="709"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9M9"/>
    <dbReference type="GeneID" id="33558565"/>
    <dbReference type="InParanoid" id="A0A1Y1U9M9"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000101">
        <property type="entry name" value="Wos2 protein (P21), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="180" mass="19686" checksum="BDCEE3EE558AC5FB" modified="2017-08-30" version="1">MADSSSKPTHPEITYAERSSATEPEKNIIYFTINAPNIDGEPKLEIKPTEISFFAKAGDPSKGVPSKEFAFDLQLYDEIIPEETKKVVNERAILLILRKKTAKAEYWPRLTKEKPNRNWVKTDFSKWVDEDEQEGAEIEDMSGMGGMGGMGGMEGMGGMGGMGGMGGGMGGMDFVSLSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1U9N3</accession>
    <name>A0A1Y1U9N3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD324DRAFT_646968</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868532.1">
        <property type="nucleotide sequence ID" value="XM_022017634.1"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1U9N3"/>
    <dbReference type="GeneID" id="33559443"/>
    <dbReference type="InParanoid" id="A0A1Y1U9N3"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="21">
        <location>
            <begin position="558"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="258"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="729"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1451"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1623"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="933"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="964"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1451"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1646"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1670"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="1692"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1714"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ORX34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1725" mass="190400" checksum="E99D1FEB5FCFBD1C" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAH1</accession>
    <name>A0A1Y1UAH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_636145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868759.1">
        <property type="nucleotide sequence ID" value="XM_022016872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAH1"/>
    <dbReference type="FunCoup" id="A0A1Y1UAH1">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAH1"/>
    <dbReference type="GeneID" id="33558681"/>
    <dbReference type="InParanoid" id="A0A1Y1UAH1"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05243">
        <property type="entry name" value="SDR_a5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="241" mass="26241" checksum="8C14A48676A18B4B" modified="2017-08-30" version="1">MKFVIFGGGGKVARHFTRIASGQGHKVVCVVRNDSHHSDLESMGGKPSILSIEDATVPQITDLLSDHKPDAVIFSAGAGGKGDPSRTTKVDFEGAVKVFDAMEAANVRRLLYVGAIDVRDRDKGYPKHYTQESKDSSDKTWNAIGRYMDAKYKAEVELHSRKALQYTVLRPGGLTMEPAGKCQMGLCQTGKTSRELVAKALLACANEPKSEGLTIDLMDGDGELEAELSKVVEQRIDAWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAQ9</accession>
    <name>A0A1Y1UAQ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="11" type="ORF">BD324DRAFT_636532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="NBSH01000014">
        <property type="protein sequence ID" value="ORX34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAQ9"/>
    <dbReference type="FunCoup" id="A0A1Y1UAQ9">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UAQ9"/>
    <dbReference type="InParanoid" id="A0A1Y1UAQ9"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="10">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="180"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="63"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="275" mass="29379" checksum="C941B44ABC8EB738" modified="2017-08-30" version="1">MSAASASSSSGGGELEYLKSLVSQLQVKIEQLEKSASNAVQSAKQAVTGAADGPKLVLIGPPGAGKGTQAPNIAEKYCVCHLATGDMLRNQVAKQTELGKQAKKIMDQGGLVSDEIMVGMIKKELQENADCKNGFILDGFPRTVPQASKLDAMLADDKKKIDHAIELRIPDALLISRITGRLIHPASGRSYHKEFNPPKKPMTDDITGEPLIQRSDDNAETLRKRLATYHSQTGPVVDYYKKTGIWTPVDAAQSPKLVWGSIGSILSGSSKAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAU8</accession>
    <name>A0A1Y1UAU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Muts domain V-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_634151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869387.1">
        <property type="nucleotide sequence ID" value="XM_022016708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAU8"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAU8"/>
    <dbReference type="GeneID" id="33558517"/>
    <dbReference type="InParanoid" id="A0A1Y1UAU8"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="1065" mass="117958" checksum="A8DBF64F21C24028" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UAU9</accession>
    <name>A0A1Y1UAU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD324DRAFT_637089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000015">
        <property type="protein sequence ID" value="ORX34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021868483.1">
        <property type="nucleotide sequence ID" value="XM_022016969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UAU9"/>
    <dbReference type="STRING" id="4999.A0A1Y1UAU9"/>
    <dbReference type="GeneID" id="33558778"/>
    <dbReference type="InParanoid" id="A0A1Y1UAU9"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46829:SF1">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="332"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="507"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="603"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ORX34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="76192" checksum="2066ED96D9F73984" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB11</accession>
    <name>A0A1Y1UB11_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD324DRAFT_631872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869413.1">
        <property type="nucleotide sequence ID" value="XM_022016475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB11"/>
    <dbReference type="FunCoup" id="A0A1Y1UB11">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UB11"/>
    <dbReference type="GeneID" id="33558284"/>
    <dbReference type="InParanoid" id="A0A1Y1UB11"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ORX35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40771" checksum="9E0C59C4505713BF" modified="2017-08-30" version="1">MEAVAVGEVPKASLSAWRKDPTRYITGLIYLLIVVVLWTVSNFITAALEAGSDTYNKPFLITYLNTSTFTLYLLPSLLKHRKASSRGHYEAISHADIDPHACSQSVESQSLAKLTVRETAIVSAWWSIGWFLANFMITLSLAMTSVSSAVILSATSGFFTLALGSVFGVEKPTRTNISSVLLSFLGVVLVARSDSSQTEEISVPLPSHPIWGDLAAIISALCYGGYVVLLKVKLVDEDRADSMLMLGFAGLYQTVALIPVFPILHWTGLERFQLPPTRRAWLLCLANMSITFASDYLYILALLKTSPMLVTLGLSMTIPLTLAISIVDPALSVGTVTFLSLIGASMVLGAFVLLSWEGTKEDEQASPPIDTGREGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UB52</accession>
    <name>A0A1Y1UB52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_85682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869451.1">
        <property type="nucleotide sequence ID" value="XM_022019267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UB52"/>
    <dbReference type="STRING" id="4999.A0A1Y1UB52"/>
    <dbReference type="GeneID" id="33561076"/>
    <dbReference type="InParanoid" id="A0A1Y1UB52"/>
    <dbReference type="OrthoDB" id="2561803at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21193" checksum="E4FE4D184616416D" modified="2017-08-30" version="1">MMSGTATQHSLFTAGVKVPNIWLATDPSHGFNLCFVELLEGMPWTRPSNLGSHQVLRTVRDYAEWNIQCTKLSYDRIGSLIHGNEATIGPFIWLDKWNPEPPYFPGPFRTLAERYMAFIDMNLDYITLGINSRRDPLKAYLLHLELRELIASDVQLSQNVEETFIKHGDAGGSHIMVDTEGSISGIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UBZ2</accession>
    <name>A0A1Y1UBZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD324DRAFT_633753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000012">
        <property type="protein sequence ID" value="ORX35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869270.1">
        <property type="nucleotide sequence ID" value="XM_022016656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UBZ2"/>
    <dbReference type="STRING" id="4999.A0A1Y1UBZ2"/>
    <dbReference type="GeneID" id="33558465"/>
    <dbReference type="InParanoid" id="A0A1Y1UBZ2"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="11">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ORX35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="188" mass="21021" checksum="CD9037A8EC53CF13" modified="2017-08-30" version="1">MSDRGWNQRSIDETYFPRPGQMSESLKRARRPFIWPNRIYGLGLVCFSLGIYAYSIAAVQQDDFSDVEDLLPPVEERSSLKSIEDEEREKGGPSHLRRIPGSLSTGSAMSPPPPGQKDWGGSSDHMGPGHSGRWYSSFLPRRLSDIEWVRRAGLVERESGNVLVWAAPPIDQNMRIGDGKPSKGPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCC9</accession>
    <name>A0A1Y1UCC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD324DRAFT_631301</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 13">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000010">
        <property type="protein sequence ID" value="ORX35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869864.1">
        <property type="nucleotide sequence ID" value="XM_022016419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCC9"/>
    <dbReference type="FunCoup" id="A0A1Y1UCC9">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCC9"/>
    <dbReference type="GeneID" id="33558228"/>
    <dbReference type="InParanoid" id="A0A1Y1UCC9"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000035">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="14">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ORX35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="123" mass="14139" checksum="19E8BD345C6B69B0" modified="2017-08-30" version="1">MPALKFCGECNNLLYPKSDNNSKILLYQCRNCNYSENAVPEPGMAPCVYKHDLLTVAREQAGETKDLETDPTLQRSDIQCPRCFNNGAVFFQDQARRITTNMTLFFSCVNCKFLFRDPKVKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCJ1</accession>
    <name>A0A1Y1UCJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUR7/PalI family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_83649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869424.1">
        <property type="nucleotide sequence ID" value="XM_022019261.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ORX35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27374" checksum="78C7BCC2B59AD280" modified="2017-08-30" version="1">MLARAAFPAFFLVLGGFIMFLLVTLSVPIIKTIYLLKIEYPGGSTAANIGVLGTCFKGGNAEFLGFDYSGTAYCTDPKVGYRIDPSLLGYDGSRNTSSIIVRALSGSLIINALAAGFAGFSLFFAFFAWLCASRVMEIILFITMFFTAFVAWIAWALDCALTLVARRRVDNYTSGTFSGHIGNAFWLALAGAFALSFGLCFAGCGMFGRYSRPRENYVGNNVAPSGAPAMAEKPAGRRRWPWQRNTAYRGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCP3</accession>
    <name>A0A1Y1UCP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_635239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000013">
        <property type="protein sequence ID" value="ORX34835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869077.1">
        <property type="nucleotide sequence ID" value="XM_022016797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCP3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UCP3"/>
    <dbReference type="GeneID" id="33558606"/>
    <dbReference type="InParanoid" id="A0A1Y1UCP3"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052293">
        <property type="entry name" value="SRRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239:SF41">
        <property type="entry name" value="MEMBRANE ASSOCIATED PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12239">
        <property type="entry name" value="PROTEIN CBG20215-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="773"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX34835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="95365" checksum="53A1878A8F4C245B" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UCS1</accession>
    <name>A0A1Y1UCS1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_582040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869537.1">
        <property type="nucleotide sequence ID" value="XM_022013540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UCS1"/>
    <dbReference type="FunCoup" id="A0A1Y1UCS1">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UCS1"/>
    <dbReference type="GeneID" id="33555348"/>
    <dbReference type="InParanoid" id="A0A1Y1UCS1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="191" mass="21276" checksum="B278C74DEB2EC1CC" modified="2017-08-30" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDDPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQVDLRDDPSHLEKLSRQKQRPITNDQGERLARELGAVKYVECSALTQRGLKNVFDEAIVAALEPPVVKKPKKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD65</accession>
    <name>A0A1Y1UD65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_652591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000011">
        <property type="protein sequence ID" value="ORX35466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021869656.1">
        <property type="nucleotide sequence ID" value="XM_022018521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD65"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD65"/>
    <dbReference type="GeneID" id="33560330"/>
    <dbReference type="InParanoid" id="A0A1Y1UD65"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ORX35466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="485" mass="51676" checksum="99D3F46DA0C2F3DA" modified="2017-08-30" version="1">MPTLASGWTVSPTTTSTSPWTYPSYFTSAMDPFKTSSSSSSSSPSASTPSGTWIHSTFPSSGFTIDSYFISASPSTPTPTPTSSLTTSPSPLSDASASVPTPPPSSTEDPQVNPSDFSVPAHGETRKAIIIWVSFGVGMLVAITILVILYRCIRRKKLASKYKRQNREGESPTTSSPTTMTDGGSRQMSQIRNGMVTPGRLFGGDLTTDDVASAVVISGSTVNPPRIPPRTVVRNTRAPSTQWGSDDSEYDMVATDGSSITRTLSTRSMDTISERMESGTASTENPFNHPAYTVNRPNRRFDIPGIRTNVNSTTTTLSVASPLTLGTAETWWSNISHGRFSATSPTATTDSTTDSSMSPTTPRPLLTLDTRAAVSSTHGSSMPTSSPSTVTNSPAPTYSSHTAFSSTMPSRHDSIISQSTDRSWSQENSESSSRPTALSRGTTFIQHTDSQTGNGSAAIAGWRQSRRPKEVHLPPSYCQVYGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UD76</accession>
    <name>A0A1Y1UD76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_629846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870137.1">
        <property type="nucleotide sequence ID" value="XM_022016264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UD76"/>
    <dbReference type="STRING" id="4999.A0A1Y1UD76"/>
    <dbReference type="GeneID" id="33558073"/>
    <dbReference type="InParanoid" id="A0A1Y1UD76"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="10"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="388" mass="43584" checksum="00F34CB24FDD7004" modified="2017-08-30" version="1">MQAPGFRFNERESNPNHYVGFIRALKAEPDHTDAEMILKAVAAQMKKVMQHRYMFIHTLEEAAFNRVFAGRNWNHGQSVELVLRGPSGRFLPLPYIVSVMCHEMAHIEQMNHGPKFQKLMREIKQEVKEMQARGYYGDGFWSDGQRLKDSVRMGAEGLKPSDFPEYVCGVSASDAKKAKRRPPTGVSLTSGRQTDYNTKPARRNHADMGDNGTRLDGRREITKEDLDEKKRWIDDRAQEILTTGVSVKTARAKAGKEWAAQNPGNTRGKVAKSKTAAELRAAAAEARLAATSPDNPGGFEVPDPHLNPAQRRSQIEAEMDEDEKRQLRGGWEEFMQFDTPVKRHASPPVGARKRGRNAESTSWACAVCTYENGADQRRCDMCESLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UDJ8</accession>
    <name>A0A1Y1UDJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_657055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870240.1">
        <property type="nucleotide sequence ID" value="XM_022018856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UDJ8"/>
    <dbReference type="GeneID" id="33560665"/>
    <dbReference type="InParanoid" id="A0A1Y1UDJ8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX36111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="672" mass="74116" checksum="80B0C07515FF59B1" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE48</accession>
    <name>A0A1Y1UE48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative syntaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD324DRAFT_642516</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870421.1">
        <property type="nucleotide sequence ID" value="XM_022017489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE48"/>
    <dbReference type="FunCoup" id="A0A1Y1UE48">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE48"/>
    <dbReference type="GeneID" id="33559298"/>
    <dbReference type="InParanoid" id="A0A1Y1UE48"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="78"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ORX36320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="332" mass="37057" checksum="F9B1FB251CB3E2B9" modified="2017-08-30" version="1">MARNRLAGVNQQYGDSQAPGNSYPPPSNAVVGQSRSDNPYAQQDYSAAPGPGNYNQYNQQSYGAGNGAPAGGDFWAELSSTNTNLAQLQEEIQAVRTAHQQSLASTDPQATAYADQLNDQARATREQCKNQIKRLFKMTKGDKAMKGQAEAVKTRFTSLLNEHQVVEKEFRKKVKDRVERQYRIVNPQATDEEVRQVTESDNPQVFSQALLSSNRYGAARGAFREVQERHAEIQKIERTLTELAQMFQEMSMLVEQQDETIANVEQQAMGVDQNISEGLNQTTRAVDSARKARRKKWICFWICILIICVAIAITFGVLAAEGKFNNNNNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE55</accession>
    <name>A0A1Y1UE55_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD324DRAFT_651571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870432.1">
        <property type="nucleotide sequence ID" value="XM_022018356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE55"/>
    <dbReference type="STRING" id="4999.A0A1Y1UE55"/>
    <dbReference type="GeneID" id="33560165"/>
    <dbReference type="InParanoid" id="A0A1Y1UE55"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX36331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="140" mass="16152" checksum="93CB6A9CA34430C5" modified="2017-08-30" version="1">METNTANASSPVLQMPQLPRTDEGRRMCQVIKVKPEALDEYKRVHAEVWPEVLGALRKANVVDYSIHYFEPLSLLIAHMRYVGPHAEFRKKMQEISENEATRRWWKMTDGMQESFIPGATGSEDPKGWWSGAEEVFRMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UE82</accession>
    <name>A0A1Y1UE82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bud-site selection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD324DRAFT_628521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870462.1">
        <property type="nucleotide sequence ID" value="XM_022016122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UE82"/>
    <dbReference type="FunCoup" id="A0A1Y1UE82">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UE82"/>
    <dbReference type="GeneID" id="33557931"/>
    <dbReference type="InParanoid" id="A0A1Y1UE82"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="75"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ORX36361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="526" mass="56957" checksum="A3AF4B74EBDB0A92" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEL4</accession>
    <name>A0A1Y1UEL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_651707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870569.1">
        <property type="nucleotide sequence ID" value="XM_022018378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEL4"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEL4"/>
    <dbReference type="GeneID" id="33560187"/>
    <dbReference type="InParanoid" id="A0A1Y1UEL4"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="377"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="750" mass="82528" checksum="0241C391EDF33394" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEM0</accession>
    <name>A0A1Y1UEM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative late endosome to vacuole transport-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD324DRAFT_651887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX35977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870106.1">
        <property type="nucleotide sequence ID" value="XM_022018409.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A1Y1UEM0">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEM0"/>
    <dbReference type="GeneID" id="33560218"/>
    <dbReference type="InParanoid" id="A0A1Y1UEM0"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="6">
        <location>
            <begin position="1939"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="7">
        <location>
            <begin position="3036"/>
            <end position="3141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1375"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1559"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1705"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1378"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1567"/>
            <end position="1579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ORX35977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="3168" mass="354035" checksum="B913B6D2AC84F745" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UES7</accession>
    <name>A0A1Y1UES7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD324DRAFT_629236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000008">
        <property type="protein sequence ID" value="ORX36528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870629.1">
        <property type="nucleotide sequence ID" value="XM_022016184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UES7"/>
    <dbReference type="STRING" id="4999.A0A1Y1UES7"/>
    <dbReference type="GeneID" id="33557993"/>
    <dbReference type="InParanoid" id="A0A1Y1UES7"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="374"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ORX36528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="600" mass="65109" checksum="21B7A812E9B54CE9" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEV1</accession>
    <name>A0A1Y1UEV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD324DRAFT_629943</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000009">
        <property type="protein sequence ID" value="ORX36044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870173.1">
        <property type="nucleotide sequence ID" value="XM_022016278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEV1"/>
    <dbReference type="FunCoup" id="A0A1Y1UEV1">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="4999.A0A1Y1UEV1"/>
    <dbReference type="GeneID" id="33558087"/>
    <dbReference type="InParanoid" id="A0A1Y1UEV1"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="278"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ORX36044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="368" mass="39408" checksum="D48C05816189F97C" modified="2017-08-30" version="1">MSSAAPRPKPWETSQTQAGSASNGPSAFETAVATSSSNTAPKLPDRPAGFDIAGPSNYAQSSLYQPRYTTPSYGMSNYGGYGGYSGYGYGGPMSRFGGAGGYGYGGGYGMGGYGVGGMGGPGEGYPTLTSSLQATTAPAFAIIESIVTAFTSLAQLVESTYMATHSSFFAMVGVADQLGSLKTYLGQVLGVFSILRLGRRIVAWLRGKKINTEGWANEWTAGGGPPAERPSSKPLILFLLSAVGLPWLMSRLVKLLIATTAQQQQQGMIASDGTLDPSKLVFARARWEFNANEEWELPLGRDEIVAVLERRDNGSSEQERGWWRGRLRNGKTGWFPGNHVEIIKRRDQQKQQQPQPQQEQNPPKPGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UEZ3</accession>
    <name>A0A1Y1UEZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIB component B'' Myb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD324DRAFT_651116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NBSH01000007">
        <property type="protein sequence ID" value="ORX36630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_021870699.1">
        <property type="nucleotide sequence ID" value="XM_022018271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UEZ3"/>
    <dbReference type="STRING" id="4999.A0A1Y1UEZ3"/>
    <dbReference type="GeneID" id="33560080"/>
    <dbReference type="InParanoid" id="A0A1Y1UEZ3"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="680"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
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            <end position="11"/>
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            <dbReference type="Pfam" id="PF15963"/>
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            <dbReference type="EMBL" id="ORX36630.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
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    <sequence length="820" mass="90195" checksum="7F30589A81A21A4F" modified="2017-08-30" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFA1</accession>
    <name>A0A1Y1UFA1_9TREE</name>
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        <submittedName>
            <fullName evidence="6">Peroxisomal biogenesis factor 11</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BD324DRAFT_626860</name>
    </gene>
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        <name type="scientific">Kockovaella imperatae</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Tremellomycetes</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
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                <person name="Magnuson J."/>
                <person name="James T.Y."/>
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                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">NRRL Y-17943</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1Y1UFN0_9TREE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kockovaella imperatae</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
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                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
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                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
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                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
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                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">NRRL Y-17943</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022016200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Y1UFN0"/>
    <dbReference type="GeneID" id="33558009"/>
    <dbReference type="InParanoid" id="A0A1Y1UFN0"/>
    <dbReference type="Proteomes" id="UP000193218">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ORX35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000193218"/>
        </source>
    </evidence>
    <sequence length="71" mass="7930" checksum="323060B7B4D387A1" modified="2017-08-30" version="1">MHRPIATQSILTALPVTRTLPVTRSTDPEFCDHHLSESVWDAATDCATSGSSCDWIHIRMHKAWSWAILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-08-30" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Y1UFP8</accession>
    <name>A0A1Y1UFP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD324DRAFT_476413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kockovaella imperatae</name>
        <dbReference type="NCBI Taxonomy" id="4999"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cuniculitremaceae</taxon>
            <taxon>Kockovaella</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-03" db="EMBL/GenBank/DDBJ databases">
            <title>Widespread Adenine N6-methylation of Active Genes in Fungi.</title>
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                <person name="Mondo S.J."/>
                <person name="Dannebaum R.O."/>
                <person name="Kuo R.C."/>
                <person name="Louie K.B."/>
                <person name="Bewick A.J."/>
                <person name="Labutti K."/>
                <person name="Haridas S."/>
                <person name="Kuo A."/>
                <person name="Salamov A."/>
                <person name="Ahrendt S.R."/>
                <person name="Lau R."/>
                <person name="Bowen B.P."/>
                <person name="Lipzen A."/>
                <person name="Sullivan W."/>
                <person name="Andreopoulos W.B."/>
                <person name="Clum A."/>
                <person name="Lindquist E."/>
                <person name="Daum C."/>
                <person name="Northen T.R."/>
                <person name="Ramamoorthy G."/>
                <person name="Schmitz R.J."/>
                <person name="Gryganskyi A."/>
                <person name="Culley D."/>
                <person name="Magnuson J."/>
                <person name="James T.Y."/>
                <person name="O'Malley M.A."/>
                <person name="Stajich J.E."/>
                <person name="Spatafora J.W."/>
                <person name="Visel A."/>
                <person name="Grigoriev I.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOT